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Incidence Of Bacterial Chondronecrosis With Osteomyelitis Lameness In Commercial Duck Flocks In Mojokerto, Indonesia, Andi Asnayanti, Siti Azizah, Anif Mukaromah Wati, Ahmad Ridwan, Ahmad Arman Dahlan, Dinda Rosalita, Anh Dang Trieu Do, Adnan Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial Chondronecrosis with Osteomyelitis (BCO) lameness is an infection of opportunistic bacteria in the structural skeletal bones impacting multiple animal species, particularly poultry species. BCO lameness results in significant financial losses to industrial poultry production and increases the risk of foodborne illnesses, posing a major threat to consumers' food safety. As BCO lameness is an inherent risk of fast body weight gain in poultry species, especially broiler chickens, abundant studies have been conducted in broilers and turkeys. Nevertheless, BCO lameness incidence in ducks remains elusive. Thus, this is the first survey investigating the prevalence of BCO lameness cases in ducks. …

Preliminary Investigation Of Cecal Microbiota In Experimental Broilers Reared Under The Aerosol Transmission Lameness Induction Model, Anh Dang Trieu Do, Khawla Alharbi, Ruvindu Perera, Andi Asnayanti, Adnan Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO), and its associated lameness, is one of the most common and devastating issues the poultry industry constantly faces, both globally and domestically. Leveraging the currently accepted "leaky gut" model of pathogenesis, this study aims to evaluate the cecal community of broilers reared under the aerosol transmission BCO induction model. A trial involving 1320 Cobb 500 broilers was conducted using the same induction model for 56 d with the following treatments: (1) positive control (PC)-untreated birds on wire-flooring pens; (2) negative control (NC)-untreated birds on litter-flooring pens; (3) LOW-birds treated with probiotic Enterococcus faecium spray on …

Enhancing Silicon Sampling In Large Language Models: Fine-Tuning Techniques Using Survey Data, Davis P. Forster

Theses and Dissertations

Large language models (LLMs) are increasingly used to simulate responses of human demographic groups, a task known as silicon sampling. This paper investigates whether supervised fine-tuning can improve algorithmic fidelity in such settings. We construct a dataset from the General Social Survey (GSS), converting demographic attributes into natural-language backstories and randomly selecting one attribute as a held-out target. Fine-tuning a LLaMA-3.1-70B model on this dataset yields significant improvements on two tasks: (1) imputing missing attributes at the individual level, and (2) reproducing response distributions for demographic slices, such as racial and age groups. Notably, these improvements are achieved with minimal …

Reframing The Nature Of Strategic Competition, Antulio J. Echevarria Ii

The US Army War College Quarterly: Parameters

In this Corner, Dr. Antulio J. Echevarria II, professor of strategic competition at the US Army War College, critiques the essential concepts underpinning US doctrine concerning intrastate strategic competition. In this, his inaugural contribution, Dr. Echevarria discusses the shortfalls in the Joint concept of interstate strategic competition, namely, its failure to capture the true nature of that competition. A more extensive reading of the scholarly literature on strategic rivalry suggests the nature of strategic competition should be reframed to align more closely with the nature of war.

The Feasibility Of Transaldolase Inhibitors As Anti-Cancer Therapeutics, Daniel Scot Baer

Chemistry and Biochemistry

Metabolism was a major focus of cancer research 100 years ago, but its prevalence declined in the latter part of the twentieth century. In the last several decades, however, it has become clear that cancer cells frequently modify their metabolic programs to enable both their survival and rapid proliferation. Transaldolase (TA), an enzyme within the pentose phosphate pathway, contributes to these outcomes when its activity is increased, yet for a variety of reasons inhibition of the enzyme has remained comparatively understudied. Since TA flux enables nucleotide production and high levels of NADPH synthesis, aberrant, cancer-causing signaling pathways often increase expression …

Cyber-Physical Framework For Smart Paint Manufacturing: Hybrid Integration Of Plc And Recipe Management Simulation, Stephen A. Michael, Anas M. Atieh, Emmanuel Nkwocha, Nathir A. Rawashdeh

Michigan Tech Publications

This study investigates the implementation of Industry 4.0 paradigms in the context of smart paint manufacturing, focusing on process control and recipe management through the integration of Ignition SCADA, a Siemens programmable logic controller (PLC), and a MySQL Workbench database. The developed architecture employs Ignition as an interoperable communication interface that facilitates bidirectional data exchange between the PLC and the database, thereby establishing a cyber-physical system for automated monitoring and control. The digital recipe management module formalizes paint formulations into parameterized datasets specifying paint and solvent ingredient ratios, process variables, and operational constraints, which are executed autonomously by the control …

Discourse, Power, And Pedagogy In Ai And Human-Designed Efl Lesson Plans: A Clil And Systemic Functional Linguistic Perspective, Christian D. Libunao, Vincent A. Morales

Journal of English and Applied Linguistics

The integration of generative artificial intelligence (GAI) into English language teaching (ELT) raises important questions about how AI-generated lesson plans shape pedagogy, interaction, and ideology compared to human-designed materials. This study examines how ChatGPT-generated lesson plans converge with or diverge from those published by the British Council, with particular attention to teacher and learner roles, classroom power dynamics, and pedagogical scaffolding. A triadic framework combining systemic functional linguistics (SFL), critical discourse analysis (CDA), and content and language integrated learning (CLIL) was applied to three British Council lesson plans and three thematically matched ChatGPT outputs. Findings reveal that both sets of …

Framing Of Immigration In The News And Its Effects On Social Media Discourse On The Southcoast Of Massachusetts, Mariel Surprenant

Political Science Undergraduate Theses

Why do immigrant communities often express anti-immigrant sentiment? This study will focus on examining what political discourse about immigration dominates the news ecosystem of the Southcoast of Massachusetts, and what effect that discourse has. Immigration in the U.S. has become an increasingly politicized issue, dominating political discourse, motivating voter behavior, and shaping regional political identities. This study will use content analysis of Southcoast newspapers to examine how the local news frames immigration and discourse analysis to examine the opinions of everyday citizens revealed as by their social media comments on posts about immigration by the same local news sources. The …

Comparative Analysis Of Machine Learning And Statistical Models For Railroad–Highway Grade Crossing Safety, Erickson Senkondo, Deo Chimba, Masanja Madalo, Afia Yeboah, Shala Blue

Civil and Architectural Engineering Faculty Research

Railroad-highway grade crossings (RHGCs) are critical points of conflict between roadway and rail systems, contributing to over 2000 crashes and 250 fatalities annually in the United States. This study applied machine learning methods (ML) techniques to model and predict crash frequency at RHGCs, using a comprehensive dataset from the Federal Railroad Administration (FRA) and Tennessee Department of Transportation (TDOT). The dataset included 807 validated crossings, incorporating roadway geometry, traffic volumes, rail characteristics, and control features. Five ML models—Random Forest, XGBoost, PSO-Elastic Net, Transformer-CNN, and Autoencoder-MLP—were developed and compared to a traditional Negative Binomial (NB) regression model. Results showed that ML …

Exercise And Its' Impact On Student's Mental Health, Braden Wolf

Psychology Student Publications

This paper examines how exercise positively impacts the mental health of college students, a group especially vulnerable to mental health challenges. It reviews empirical evidence showing that exercise improves self-efficacy, reduces negative emotions, and lowers suicide risk by enhancing confidence, sleep, academic success, and reducing depression, anxiety, and stress. While exercise is not a complete solution to mental health issues, it can significantly alleviate symptoms and prevent further distress.

Functional Characterization Of Abcc8 Mutations Potentially Linked To The Transition From Hyperinsulinemic Hypoglycemia To Diabetes, Hao Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

ATP-sensitive potassium (KATP) channels, composed of the SUR1 and Kir6.2 subunits encoded by the ABCC8 and KCNJ11 genes, are critical regulators of membrane excitability and insulin secretion in pancreatic β-cells. Gain-of-function (GOF) mutations in these genes cause neonatal diabetes mellitus through impaired insulin secretion and persistent hyperglycemia, whereas loss-of-function (LOF) mutations lead to congenital hyperinsulinism (CHI) with hypoglycemia due to β-cell hyperexcitability. I have addressed a paradoxical form of maturity-onset diabetes of the young (MODY) arising from KATP mutations, in which patients transition from CHI to glucose intolerance later in life. My experiments indicate that many KATP mutations associated with …

The Relationship Between K-12 Public School Funding, Per Pupil Expenditures, And Student Achievement, Regina R. Frazier-Bagley

Walden Dissertations and Doctoral Studies

Public school district leaders are challenged with funding K-12 education that creates the desired student academic performance. Grounded in student-based budgeting theory, this quantitative ex post facto study aimed to investigate the relationship between K–12 public school funding, per-pupil expenditures, student achievement, and graduation rates in Georgia. The study included secondary data from 51 North Georgia public school districts for the 2018–2019 school year. Multiple regression analysis was completed to examine the relationship between the independent variables—state funding, per-pupil expenditures, and academic achievement in math, science, and language arts—and the dependent variable: graduation rates. The results of the analysis were …

Employees’ Perceptions Of Leaders’ Diversity Training For Supporting Organizational Equity, Michelle L. Burchfield

Walden Dissertations and Doctoral Studies

Despite growing organizational attention to diversity, equity, and inclusion, some workplaces continued to struggle with embedding equitable practices. The research problem addressed in this study focused on understanding how employees perceived leaders’ diversity training and its effectiveness in supporting organizational equity. The purpose of this qualitative interpretative phenomenological study was to explore employees’ perspectives of leadership diversity training and its role in supporting organizational equity. Behavioral leadership theory and critical race theory grounded this study. The participants consisted of 10 employees with experience in leadership diversity training in Kentucky, Ohio, and Indiana. Data were collected using semistructured interviews. Seven most …

Reducing The Use Of Erythropoiesis-Stimulating Agents In Hemodialysis Patients, Myriamme Neree

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project was a quality improvement (QI) initiative. Nephrologists were inconsistent in ordering iron studies and sometimes delayed the initiation of erythropoiesis-stimulating agents (ESAs) on admission to the inpatient site. These delays often led to suboptimal outcomes. The practice-focused question guiding the project asked whether a nurse-driven iron protocol would improve adherence to anemia management guidelines. The project’s purpose was to evaluate the impact of the evidence-based nurse-driven protocol. I used descriptive and inferential statistics for data analysis. Findings demonstrated a statistically significant improvement in the timely completion of iron studies and in intravenous (IV) iron …

Secondary Education Teachers’ Perspectives On School-Based Mental Health Resources, Madison Rose Litterell

Walden Dissertations and Doctoral Studies

Approximately one in six youth ages 6 to 17 years old in the United States have a mental health disorder, such as depression and anxiety. Out of the 119,000 youth in Michigan in that age group, roughly 57.8% are not receiving proper mental health support services. Students are at school for a large majority of their day, so it is important that they have access to school-based services. The purpose of this basic qualitative study was to understand the perceptions of secondary education teachers in Wayne County, Michigan, on school-based mental health support services. Using the community level and the …

Effective Strategies To Reduce Burnout For Employees With High Workload Demands, Michelle Healy

Walden Dissertations and Doctoral Studies

Ineffective strategies to reduce burnout for employees can decrease productivity and quality of work, and can increase turnover. Event industry leaders who struggle to reduce burnout of employees with high workload demands are at risk of employee turnover. Grounded in the Job Demands-Resources (JD-R) model, the purpose of this qualitative, pragmatic inquiry research project was to explore effective strategies to reduce burnout for employees with high workload demands. The participants were eight event industry leaders who had effectively implemented strategies to reduce burnout. Data were collected using semistructured interviews and a review of public websites and documents. Using thematic analysis, …

Microbial Communities Of Selected Regions Of The Deep Springs Lake Aquifer System, Rania Zaki, Emma Bourne, Andrew Storino, Jay Nadeau

Physics Faculty Publications and Presentations

Deep Springs Lake is a small, isolated, highly alkaline soda lake in Inyo County of Eastern California, USA. It is a seasonally filled salt lake or playa, and is part of a closed aquifer system. Such closed systems are globally rare, occurring only in arid zones where annual evaporation is greater than annual rainfall. Deep Springs Lake’s hydrology and geology have been well studied, and it is home to a unique toad species, but its microbiome remains unexplored. Here we perform 16S, 18S, and ITS amplicon sequencing of the lake water, dried salt crust at the edges the lake, and …

Postoperative Anaemia: The Unseen Challenge In Cardiac Surgery, Matthew A. Warner, Jacob Raphael

Department of Anesthesiology Faculty Papers

Postoperative anaemia is an overlooked complication of cardiac surgery that is associated with adverse clinical outcomes. Although small clinical trials suggest that postoperative treatment with i.v. iron improves haemoglobin recovery and reduces transfusion utilisation, appropriately powered randomised controlled trials are necessary to definitively evaluate the efficacy of treatment on clinical outcomes of importance to patients, clinicians, and healthcare systems. A comprehensive approach to perioperative anaemia management demands a renewed focus on both prevention and treatment to improve patient outcomes.

Investigating The Polygenic Relationship Between Heavy Cannabis Use And Schizophrenia In The All Of Us Research Program, Isabelle Austin-Zimmerman, Hayley H A Thorpe, John J Meredith, Jibran Y Khokhar, Tian Ge, Marta Di Forti, Arpana Agrawal, Emma C Johnson, Sandra Sanchez-Roige

2020-Current year OA Pubs

BACKGROUND: Decades of research have identified a strong association between heavy cannabis use and schizophrenia (SCZ), with evidence of correlated genetic factors. However, many studies on the genetic relationship between cannabis use and psychosis have lacked data on both phenotypes within the same individuals, creating challenges due to unmeasured confounding. We aimed to address this by using multimodal data from the All of Us Research Program, which contains genetic data as well as information on SCZ diagnosis and cannabis use.

METHODS: We tested the association between cannabis use disorder (CUD) and SCZ polygenic scores (PGSs) with SCZ and heavy cannabis …

Cosmic Legends, Neha Ravindra Hiremath

Theses

Cosmic Legends is a touchscreen-based interactive kiosk that invites users to explore how different cultures interpret the same star—Betelgeuse. Designed for public educational settings, it blends visual storytelling, mythology, and voice interaction into a cohesive learning experience. This project challenges the Eurocentric approach of most astronomy tools by introducing global narratives rooted in Navajo, Tupi, and Japanese sky traditions. Users begin by tapping a glowing version of Betelgeuse, which transforms the night sky into a new cultural context. Each sky shift is paired with narrated myths, synchronized captions, and celestial motion design. The interface prioritizes accessibility with dyslexia-friendly text, high-contrast …

Evaluating The Feasibility Of Digital Twin Adoption For Mep Systems, Tejas Adana

Theses

MEP systems dominate building operational costs, yet facility teams continue battling reactive maintenance cycles that result in unexpected equipment failures, emergency callouts, and continuous energy inefficiencies. Digital twin technology presents a practical solution by creating live virtual replicas that shift operations from firefighting breakdowns to anticipating issues before they escalate. However, adoption remains limited due to fragmented implementation guidance, short-term validation studies, and minimal research addressing emerging market contexts. This research employs a grounded approach combining systematic literature analysis, candid discussions with MEP engineers and facility managers across UAE commercial properties, and practical prioritization frameworks assessing real-world impact against implementation …

Her2-Low And Her2-Ultralow Metastatic Breast Cancer And Trastuzumab Deruxtecan: Common Clinical Questions And Answers, Nusayba A Bagegni, Karthik V Giridhar, Daphne Stewart

2020-Current year OA Pubs

Approximately 80% of invasive breast cancers are classified as human epidermal growth factor receptor 2 (HER2)-negative; however, many of these tumors have detectable levels of HER2 surface expression. Trastuzumab deruxtecan (T-DXd) is a HER2-directed antibody-drug conjugate with a membrane-permeable payload that is cytotoxic to both HER2-expressing tumor cells and neighboring cells via the bystander antitumor effect. T-DXd has shown significant antitumor activity in clinical trials for patients with HER2-positive (immunohistochemistry [IHC] 3+ or IHC 2+/in situ hybridization [ISH]+) breast cancer. In addition, the results of the DESTINY-Breast04 trial demonstrated the clinical benefit of T-DXd in patients with HER2-low (IHC 1+ …

Effects Of Exposure Route And Surface Coating On The Bioaccumulation Of Cdte Quantum Dots In Fish. Considerations For Testing Nanomaterials Following Oecd Test Guideline No. 305, Judit Kalman, Rocío Fernández-Saavedra, Carla Díaz-Tielas, Mona Connolly, Ana I. Cardona-García, Nathaniel Clark, Richard D. Handy, Eric A.J. Bleeker, Isabel Rucandio, José María Navas, María Luisa Fernández-Cruz

School of Biological and Marine Sciences

To identify nanomaterials of potential environmental concern and to support risk assessment for regulatory purposes bioaccumulation testing is required. However, further guidance is needed when applying the fish bioaccumulation OECD test guideline (TG) No. 305 to nanomaterials. Also questions remain surrounding the most appropriate exposure route and if subtle modifications to these materials (e.g. different coatings) will influence bioaccumulation potential. Therefore in this study OECD TG 305 was applied to assess the bioaccumulation potential of CdTe quantum dots (QDs) with additional considerations for testing nanomaterials. CdTe QDs were selected for our studies because of their increasing use, possible release to …

40 Priority Questions To Advance Understanding Of The Risks And Opportunities Of Uk Marine Heatwaves, Zoe Jacobs, Kathryn E. Smith, Jules B. Kajtar, Dan A. Smale, Pippa J. Moore, Fabrice Stephenson, Michael T. Burrows, Caroline Rowland, Richard Renshaw, Sophy Oliver, Martyn Jakins-Pollard, Freya Ivy Palmer, Alice Kloker, Craig Baker-Austin, Bryony Townhill, Sian Rees, Sarah Coulthard, Ekaterina Popova

School of Biological and Marine Sciences

Marine heatwaves (MHWs) are periods of anomalously warm sea temperatures that are becoming increasingly recognised as ocean stressors. Globally, MHWs have impacted marine ecosystems, with significant socioeconomic implications for coastal communities and industries. The unprecedented MHW that occurred in the waters surrounding the UK and Ireland in summer 2023 highlighted a crucial gap in our understanding of the region-specific characteristics of MHWs and their impacts on marine ecosystems, the services they underpin, the blue economy and society. Using diverse expert opinion, we propose 40 priority questions for interdisciplinary research in the UK that must urgently be addressed to prepare for …

Co-Production Of A Mobile Application For Parents Of Acutely Ill Children Under Five: ‘Ipoorly Child Symptom Checker, Sarah Neill, Amy Rathbone, John Downey, Monica Lakhanpaul, Matt Carey

School of Nursing and Midwifery

Acutely ill children under five years of age are frequent and increasing users of urgent and emergency care services despite there being no increase in acuity of presenting illnesses. This raises concerns about parents’ level of knowledge and confidence in assessing the severity of symptoms of acute illness, despite the abundance of digital information available. MethodBuilding on prior work to co-develop the content for a mobile app for parents of acutely ill children, we co-designed the iPoorly child symptom checker app using an experience based co-design methodology with seven parent and seven health professional patient and public involvement representatives. The …

100 Years: The Uniform System Of Accounts For The Lodging Industry (Usali) 12th Revised Edition, Agnes Defranco, Raymond S. Schmidgall

Journal of Hospitality Financial Management

No abstract provided.

Endocrine Disruptors, Obesity, And Metabolic Syndrome, Tuğba Barlas, Alev Eroğlu Altinova, Meriç Coşkun, Ethem Turgay Ceri̇t

Turkish Journal of Medical Sciences

The global prevalence of obesity and metabolic syndrome (MetS) is rising worldwide, and increasing evidence suggests that chemical exposures—particularly endocrine disruptors (EDs)—represent a significant contributing factor. EDs can act as obesogens, increasing the risk of weight gain and related metabolic conditions, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. They may also alter the basal metabolic rate, gut microbiota composition, and hormonal regulation of appetite and satiety. EDs are reported to exert their effects mainly through the peroxisome proliferator-activated receptor gamma pathway, which is primarily expressed in adipose tissue and is a key regulator of adipogenesis. Common consumer products …

Endocrine Disruptors And Children's Health, Ersen Karakiliç, Durmuş Doğan, Emre Sedar Saygili

Turkish Journal of Medical Sciences

Endocrine-disrupting chemicals (EDCs) are environmental contaminants that disrupt hormonal regulation by mimicking, inhibiting, or modifying endocrine signaling pathways. EDCs are commonly present in plastics, pesticides, industrial byproducts, and personal care products and pose substantial health risks, particularly to vulnerable groups such as infants and children. Early-life exposure is especially concerning due to the developing detoxification systems, the immaturity of the blood–brain barrier, and the ongoing organ differentiation, making these periods highly susceptible to EDCs’ harmful effects. Moreover, exposure during critical developmental periods, such as sex differentiation and neurodevelopment, can lead to significant long-term developmental impairments that persist into later life.Perinatal …

Construction Of A Unified Knowledge Graph For Cyber Threat Intelligence, Moaz Usama Hassan Mr, Khaled , Nagaty, Noura Elmaghawry

Computer Networks

The rapid expansion and variety of cyber-threat information put enormous pressure on security operations centers (SOCs) that must convert unstructured data into understandable signals and make decisions upon it. This paper develops a Cyber-Threat-Intelligence (CTI) framework that integrates vulnerability information, product inventories, and weakness taxonomies into a domain-specific knowledge graph via automatic fusing. The proposed solution covers 284,296 CVEs, 101,644 CPE identifiers, and 965 CWE weaknesses, generating more than 800,000 typed edges linking threats, assets, tactics, and mitigations in an integrated CTI Knowledge graph. The graph was cross validated against four external standard datasets achieves full coverage of ATT&CK CAPEC, …

A Play-Based Stoic Intervention: Preventive Pedagogy For Childhood Resilience, Ross William Podyma Mr

International Journal of Playwork Practice

Rates of reported childhood mental health difficulties have risen markedly in recent years, prompting a policy emphasis on early identification and rapid referral to clinical services. While such responses are vital for acute and complex presentations, there is growing concern that they may contribute to an over-pathologising of normative developmental experiences. Everyday challenges that once functioned as opportunities to build resilience are increasingly framed as early symptoms of mental disorder. This risks undermining children’s ability to cope adaptively with adversity, inadvertently fostering reliance on external intervention.

Since its inception in 2012, Sporting Communities CIC has been embedded in schools and …