Digital Commons Network^™

Utilizing The Visia Camera For Analyzing 5-Fluorouracil Treatment Efficacy For Actinic Keratosis, Emily Woolhiser, Leena Jamal, Jessica Kirk, Bertha Baum, Robert Dellavalle

Student Publications

The VISIA camera is a device that captures images of the skin, offering a detailed look at skin health by detecting changes that are often missed during physical exams and by the naked eye. It can help identify changes in UV damage, pigmentation, texture, fine lines, and redness. In dermatology, it has become a useful tool to build targeted treatment plans and follow patient progress over time. We present a case of a male patient diagnosed with diffuse scalp actinic keratoses who was treated with topical 5-fluorouracil (5-FU). VISIA images were taken before treatment, at one week, and again three …

Alfred L. Stewart

African American Funeral Programs

No abstract provided.

The Nursing Human Capital Value Model, Olga Yakusheva, Kathryn A. Lee, Marianne Weiss

Individual Articles

Nursing's economic value is presently framed within the dominant “outcomes-over-cost” value framework. Within this context, organizations employing nurses often use nursing budget reductions as a cost-minimization strategy, with the intent of retaining high quality outcomes. However, persistent issues such as nurse understaffing, burnout, and turnover threaten healthcare systems' capacity to deliver the quality, equitable, affordable patient care that the public requires. In this paper, we propose a new conceptual model and definition of nursing's economic value. The model development is guided by the convergence of three classic economic frameworks:human capital theory, production theory, and value theory. Grounded in these theories, …

Integrating Traditional Ecological Knowledge And Environmental Science For Sustainable Lake Conservation: Danu Kerthi In Bali, Ni Kadek Surpi, Si Luh Nyoman Seriadi, Ni Wayan Jemiwi Jero

Journal of Environmental Science and Sustainable Development

This study investigates how the Danu Kerthi philosophy operates as a framework that integrates Traditional Ecological Knowledge (TEK) with environmental science to support sustainable lake conservation in three upstream lakes in Bali: Beratan, Buyan, and Tamblingan. While previous scholarship has largely focused on the normative and symbolic dimensions of Sad Kerthi, empirical evidence on its ecological effectiveness remains limited. To address this gap, the study adopts a multi-site qualitative design involving participatory observation, document analysis, and semi-structured interviews with 30 participants representing traditional leaders, Hindu priests, tourism managers, village officials, and local residents. Thematic analysis shows that Danu Kerthi continues …

Baseline Exposure-Response Assessment Of Metals From Dried Blood Spots And Personal Household Air Pollution Concentrations Among Pregnant Women In Rwanda: Household Air Pollution Intervention Network Trial, Adolphe Ndikubwimana, Lisa De Las Fuentes, Victor G Dávila-Román, Et Al.

2020-Current year OA Pubs

BACKGROUND: Exposure to metals from the combustion of biomass via inhalation may result in negative health outcomes affecting a variety of organs and systems. Pregnant women cooking with biomass fuels may be exposed to metals, such as lead (Pb) and cadmium (Cd), and have unique risks for adverse health effects with potential impacts on the growing fetus. We assessed the associations between household air pollution and metals detected in dried blood spots from pregnant women at baseline in Rwanda.

METHODS: We analyzed data from 781 pregnant women aged 18-35 years who resided in rural households using biomass fuel and who …

Development Of Self-Assembled Polymeric Polyplexes For Microrna Delivery: Toward Treatment Of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

Theses & Dissertations

Self-assembled polymeric polyplexes have the potential to serve as an RNA interference (RNAi) delivery platform for the combined inhibition of CXCR4 and miR-155 in the treatment of alcohol-associated liver disease (AALD). A central challenge in RNA delivery is balancing the extracellular stability of polyplexes, cellular uptake, and intracellular release of RNA cargo. We developed polymeric polyplexes using the CXCR4-antagonist polymer PAMD, designed to target CXCR4 on activated hepatic stellate cells (HSCs) and deliver therapeutic miRNA to activated Kupffer cells (KCs) in fibrotic liver. We improved the polyplexes by cholesterol modification of PAMD and by PEGylation of PAMD-Ch. The cholesterol modification …

Facilitators Of Routine Cervical Screening Receipt For Women With Intellectual And Developmental Disabilities In Nebraska, Anne Woodruff Jameson

Theses & Dissertations

Women with intellectual and developmental disabilities (I/DD) experience disproportionately low rates of cervical screening relative to women without I/DD, despite its clear role in cancer prevention. This disparity is especially stark in Nebraska, where in 2023, only 56% of women with I/DD had cervical screen receipt, compared to 78.4% of their non-disabled peers.. Previous literature has explored barriers to cervical screening for women with I/DD using the socioecological model (SEM) as a framework. This dissertation used three methodologies: a case study, a scoping review, and survey research, to examine facilitators to cervical screening for women with I/DD using the SEM …

Peripheral Blood Biomarkers For Rheumatoid Arthritis-Associated Interstitial Lung Disease, Brent A. Luedders

Theses & Dissertations

Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a common extra-articular complication of rheumatoid arthritis (RA). Measuring peripheral blood biomarkers represents an appealing strategy to inform the screening and prediction of RA-ILD. In these studies, I aimed to further characterize the associations of peripheral blood biomarkers with prevalent and incident RA-ILD. First, I evaluated the associations of matrix metalloproteinases (MMPs) with RA-ILD among a multicenter cohort of RA U.S. Veteran patients (n = 2,312). Higher concentrations of MMP-7 and MMP-9 were independently associated with both prevalent and incident RA-ILD, including a nearly four-fold increased odds of prevalent RA-ILD (adjusted odds ratio …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Role Of Nadph Oxidase 4 In Murine Cancer-Associated Fibroblast, Faith M. Gomez

Theses & Dissertations

Breast cancer is the second leading cause of cancer deaths in women in the United States. Frontline hormone therapies for breast cancer prove ineffective in triple negative breast cancer tumors wherein the hormones estrogen, progesterone, and HER2 are downregulated or absent; therefore, patients diagnosed with triple negative breast cancer are primarily limited to chemotherapies which carry a higher failure and resistance rate. Here we target cancer associated fibroblasts as potential drivers of chemoresistance in triple negative breast cancer. We investigated the mechanism by which Nox4 regulates the YAP/TAZ pathway in modulating DTX sensitivity and sought to determine if targeting Nox4 …

Metabolomic Profiling Reveals Brain Lipid Alterations In Pex7-Deficient Models Of Rhizomelic Chondrodysplasia Punctata, Riya Sankhe, Meredith I Williams, Wedad Fallatah, Laura Mackay, Mary Layne Brown, Pranjali Bhagwat, Sarah H Elsea, Nancy Braverman, Michael F Wangler

Duncan NRI Faculty and Staff Publications

Rhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisomal disorder characterized by skeletal shortening, intellectual disability, seizures, cataracts, and reduced lifespans. RCDP1 is caused by biallelic loss-of-function variants in PEX7, which encodes a protein required for importing select enzymes into the peroxisome matrix, including those essential for ether lipid synthesis (e.g., plasmalogens) and the branched-chain fatty acid catabolism. Plasmalogen deficiency is a hallmark of RCDP1 and other peroxisomal disorders, including RCDP types 2-5 (RCDP2-5) and Zellweger spectrum disorders (ZSD). Here, we performed comprehensive metabolomic profiling of clinical samples from RCDP patients and Pex7-deficient mouse models. We identified profound …

Single-Nucleus Multiomics Reveals The Disrupted Regulatory Programs In Three Brain Regions Of Sporadic Early-Onset Alzheimer’S Disease, Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E Sepulveda, Astrid M Manuel, Damian Gorski, Brisa S Fernandes, Meifang Yu, Paul E Schulz, Lukas M Simon, Claudio Soto, Zhongming Zhao

Faculty, Staff and Student Publications

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type–specific transcriptomic changes and linked candidate cis-regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells …

Exploring The Medicinal Properties Of Indigenous Plants Within An Enabling Program: Bridging The Gap Between School, Aboriginal And Torres Strait Islander Knowledge And Science, Sharon L. Gough, Julie Sartori, Angela Jones

Research outputs 2022 to 2026

In 2021, less than half of Australian universities considered Indigenous perspectives in curriculum development, with only 15% ensuring Indigenous content in all courses. Literature acknowledges that a strengths-based approach to the inclusion of Aboriginal and Torres Strait Islander knowledge and perspectives, enhances representation and decolonises curriculum. In 2020, Noongar elder Vivienne Hansen, and John Horsfall created Noongar Bush Medicine, detailing the medicinal use of Indigenous plants. Yeshi, Turpin, Jamtsho, and Wangchuk noted that many Aboriginal and Torres Strait Islander communities use native plants for health purposes. However, there is limited data on the therapeutic efficacy of these plants. In 2024, …

Adaptive Neuromodulation Dialogues: Navigating Current Challenges And Emerging Innovations In Neuromodulation System Development, Frederik Lampert, Matthew R Baker, Michael A Jensen, Amir H Ayyoubi, Christian Bentler, Jessica L Bowersock, Rosana Esteller, Jeffrey A Herron, Graham W Johnson, Daryl R Kipke, Christopher K Kovach, Vaclav Kremen, Filip Mivalt, Joseph S Neimat, Theoden I Netoff, Enrico Opri, Alexander Rockhill, Joshua M Rosenow, Kristin K Sellers, Nathan P Staff, Chandra Prakash Swamy, Ashwin Viswanathan, Gerwin Schalk, Timothy Denison, Dora Hermes, Nuri F Ince, Peter Brunner, Gregory A Worrell, Kai J Miller

Faculty, Staff and Students Publications

Adaptive neuromodulation systems and implantable brain-computer interfaces have made notable strides in recent years, translating experimental prototypes into clinical applications and garnering substantial attention from the public. This surge in interest is accompanied by increased scrutiny related to the safety, efficacy, and ethical implications of these systems, all of which must be directly addressed as we introduce new neurotechnologies. In response, we have synthesized the insights resulting from discussions between groups of experts in the field and summarized them into five key domains essential to therapeutic device development: (1) analyzing current landscape of neuromodulation devices and translational platforms (2) identifying …

Graphical Display Of A Career In Chronological Order With Achievement Percentiles, Safwan Samla

Defensive Publications Series

A digital representation of a person’s career is provided in a manner that is easy to follow and provides important statistics relating to achievement assessments relative to others. A person’s career can be displayed through a graphical user interface comprising an X and Y plot wherein the X-axis comprises a timeline determined by a person’s career and the Y-axis comprises data-based categories pertaining to different achievement and experiences from the person’s career.

The Contributors, Contributors Contributors

Budhi: A Journal of Ideas and Culture

Contributors

Notes For Contributors, Contributors Contributors

Budhi: A Journal of Ideas and Culture

Contributors

Socrates And Early Buddhist Medical Ethics: Foundations Of Moral Reasoning In The Care Of Body And Mind, Chandima Gangodawila

Budhi: A Journal of Ideas and Culture

While Buddhist traditions articulate a parallel moral vision in the early discourses of the Pāli Canon, Western traditions usually locate the roots of ethical reasoning in Socratic inquiry. Especially in their approaches to bodily care, spiritual well - being, and moral responsibility, this article contends that both Socratic and Early Buddhist ideas converge on fundamental principles in medical ethics. Through a comparative textual and philosophical study, the paper examines how Socratic dialectics and the Buddha's diagnostic approach to dissatisfa ction/ suffering (dukkha) both produce frameworks for ethical healthcare anchored in the development of virtue, wisdom, and care for the integrity …

Inclusive Stem Education In Nigerian Schools:An Emerging Pathway For Substainable Development, Oginni Aderonke Margaret Dr., Awobodu Victoria Yetunde Dr., Olusegun Bisola Esther Miss

Journal of Educational Research and Practice

Inclusive STEM (science, technology, engineering, and mathematics) education plays a vital role in promoting equitable learning opportunities and fostering sustainable development. However, in Nigeria, many marginalized student groups face barriers that hinder their full participation in STEM fields. This study examines the factors impeding inclusivity in STEM education and their effects on students’ motivation, academic performance, and awareness of sustainable development in Lagos State. Employing a survey research design, data were gathered from 550 students selected through simple random sampling across 21 secondary schools in Education Districts I, III, and V. A researcher-developed questionnaire was used for data collection. To …

Lessons Learned: Andreas Verykios And Kostas Tsatsaronis, Mercedes Cardona

Journal of Financial Crises

Andreas Verykios was appointed in 2018 to lead the board of directors of the General Council of the Hellenic Financial Stability Fund (HFSF), an independent special purpose vehicle created to stabilize the Greek banking sector in the wake of the country’s debt crisis. The Greek economy was badly affected by the Global Financial Crisis (GFC) and the Sovereign Debt Crisis, when the government was found to have underreported its fiscal deficits and public debt. This led to a downgrade and eventual default of its sovereign bonds, requiring assistance from the European Commission. From 2010 through 2018, the commission implemented three …

Lessons Learned: Paul Tucker, Salil Gupta

Journal of Financial Crises

After joining the Bank of England (BoE) in 1980, Sir Paul Tucker held a number of positions of increasing responsibility including serving as a member of several key committees. Tucker played a crucial role in the BoE’s response to the Global Financial Crisis (GFC) as director for markets, through March 2009, then as deputy governor of the bank until November 2013. Post-crisis, he has been instrumental in constructing the international regulatory framework on financial stability. From 2016 to 2021, Tucker also chaired the Systemic Risk Council.

Currently, Tucker is a research fellow at Harvard Kennedy School, Mossavar-Rahmani Center for Business …

Lessons Learned: Ewald Nowotny, Maryanne Chute Lynch, Rosalind Z. Wiggins

Journal of Financial Crises

Ewald Nowotny was appointed governor of the National Bank of Austria in September 2008 at the start of the Global Financial Crisis (GFC), having previously served as a vice president of the European Investment Bank in Luxembourg, the house bank of the European Union. Nowotny participated in the implementation of the multilateral stabilization framework known as the Vienna Initiative, which helped restore stability in the financial markets of Central, Eastern, and Southeastern Europe during the GFC. Working with the Austrian Central Bank, the European Commission, and the International Monetary Fund (IMF), he steered the Austrian economy away from recession. During …

Lessons Learned: Pedro Machado, Mercedes Cardona

Journal of Financial Crises

Pedro Machado began his career as a legal adviser to the European Central Bank in the years leading up the Global Financial Crisis (GFC), then joined the Bank of Portugal (BOP) in 2006, where he has held several positions. He was chief of staff to Portugal’s minister of state and finance in 2011, during the European Sovereign Debt Crisis, when the government negotiated a bailout with the International Monetary Fund (IMF) and European Union. He returned to the BOP, as deputy director of the prudential supervision department, while the program was being implemented. The EUR 78 billion bailout was largely …

Central Bank Crisis Interventions: A Review Of The Recent Literature On Potential Costs, Patrick Aldridge, David A. Cimon, Rishi Vala

Journal of Financial Crises

Central banks may engage in large-scale lending and asset purchases to stabilize financial markets and implement monetary policy during crises. The ability of these actions to restore financial market functioning is well documented; however, they come with costs. We provide a literature review of the costs associated with these post-Global Financial Crisis central bank actions, without commenting on the net benefits they provide. We find support for the premise that crisis actions may negatively impact market liquidity, distort asset prices, increase rent-seeking and inefficient uses of the liquidity provided by the central bank, create international spillovers, and create distortions in …

Proposing Augmented Reality Game-Based Learning For Higher Education, Anna C. Zaldivar

The Scholarship Without Borders Journal

Simulating the role of an instructional technologist, negotiation takes place to implement the AR technology for use in a higher education institution. There are arguments both for and against the use of augmented reality for higher education. Overall, examining and highlighting these arguments to make an important decision that will shape learners' future. Using BATNA and examining arguments during the negotiation process.

Understanding Generation Z Polarization: Findings From A Preliminary Replication Study, Liane Weintraub

The Scholarship Without Borders Journal

Amid rising polarization and declining trust in democratic institutions, Generation Z (Gen Z) faces unique challenges in navigating civic discourse. This study presents comparative findings from two survey cohorts (2023, n = 56; 2025, n = 25) examining Gen Z students’ political identity, discourse habits, interpersonal trust, and civic attitudes. Framed by Social Identity Theory (SIT), Cultural Intelligence (CQ), and discourse theory, the study explores how ideological difference and identity signaling shape students’ willingness to engage across divides. Findings indicate continuity in partisan skepticism and discourse openness, but also growing fatigue, reduced trust, and ambivalence toward equity. While affective polarization …

Black Women And Latinas In Stem: A Systematic Review Of Literature, Karin Moore

The Scholarship Without Borders Journal

This systematic review of literature examines scholarly studies conducted on Black women and Latinas in STEM fields and in STEM higher education. Women are underrepresented in STEM, and on average they comprise 27% of the STEM population (National Science Foundation, 2017). Black women and Latinas are even further underrepresented in STEM by making up only 14.58 % and 3% of the employees in STEM industries (Hispanic Heritage Foundation, 2020; National Science Foundation, 2021). Barriers for all women are the focus of much of the body of literature in STEM (Beach et al., 2024; Moore, 2024). Isolating specific challenges Black women …

Extending The Emotional And Multiple Intelligence Theories: Integrating Cultural And Spiritual Intelligence Constructs To Fill Research Gaps, Kimberly J. Mcdonald

The Scholarship Without Borders Journal

This proposed mixed-methods convergent research study aims to explore extending the Emotional Intelligence (EI) and Multiple Intelligences Theories by integrating Spiritual Intelligence (SI) and Cultural Intelligence (CQ) constructs. The goal is to explore the interconnectedness of these intelligences to bridge existing research gaps concerning leadership, EI, SI, and CQ. By employing both quantitative and qualitative data collection methods from organizational leaders, this study seeks to develop a more comprehensive and holistic understanding of leadership efficacy across various organizational contexts. The anticipated outcomes aim to contribute to the body of knowledge and potentially impact leadership development in business, education, and other …

Article Title: Deconstructing Power And Gender: A Foucauldian Discourse Analysis Of Biopolitics, Necropolitics, And Sexual Scripts In Feminicide In Puerto Rico., Migdalia Marrero-Lafontaine

The Scholarship Without Borders Journal

Feminicide and gender violence cases in the last several decades in Puerto Rico have continuously increased, suggesting that this problem becomes worse as time passes. This study, therefore, focuses on identifying actionable insights that paint a picture of the impact it has on women over the age of 18 in Puerto Rico. In order to achieve this objective, the study relies on a strong theoretical framework that is made up of Foucauldian discourse analysis, necropolitics, and sexual scripts theories. One of the core findings of this research is that Puerto Rico’s colonial history and cultural norms sustain a cycle of …

The Detrimental Impact Of Early Childhood Exposure To Pornography, Leica Marie Estomo

The Scholarship Without Borders Journal

As pornography continues to become more easily and readily accessible, children are at higher risk of viewing it. This work aims to investigate the destructive impact of premature exposure to pornography, and the negative perceptions of sex and decision-making towards it as a result. The operational definition used defines “early exposure” as prepubescents (children of elementary-grade school ages) viewing explicit material through involuntary and accidental initial engagement, and “decision-making” as moral agency and choice of response and action. The populations searched focused more on American culture and its lens on sex and pornography, with the incorporation of other cultural frameworks …