Digital Commons Network^™

Characterization Of Methylated Histone Modifications During Simian Virus 40 Early Transcription, Jacob Otto Haugen

Theses and Dissertations

Modifications of histone proteins play an important role in transcription. These modifications regulate how chromatin is compacted by the histone proteins and either made available for transcription or prevents transcription machinery from proceeding. The modifications can be added or removed by histone acetyltransferases and histone methyltransferases for the former, and histone deacetylates and demethylases for the latter. To explore the dynamicity of these modifications we used the simple but effective Simian Virus 40 (SV40) model. SV40 continues to be an important tool in understanding eukaryotic transcription. It experiences similar processes as cellular chromatin, utilizing host proteins to propagate its own …

Belongingness And Science Identity Of Underrepresented Students In Aerospace Sciences, Bella Hettich

Theses and Dissertations

Despite efforts to support underrepresented individuals—specifically those from racial, ethnic, and gender minority groups—they continue to face unique challenges that affect their belongingness in aerospace sciences, leading to issues with retention in educational programs and subsequent professional pathways. Such hindrances to personal achievement can also impede broader organizational goals. Addressing these challenges is critical, as supporting the success of underrepresented individuals fosters diverse perspectives, which are essential for driving innovation and maximizing organizational productivity. Just as importantly, ensuring that every individual, regardless of background, has access to opportunities and the support needed to succeed fulfills an ethical obligation. Upholding the …

Photometric Analysis Of Four Near-Earth Asteroids With A Convex Shape Model Of (25330) 1999 Kv4, Lucas James Hutton

Theses and Dissertations

Astrometric and photometric observations of asteroids provide information regarding their positions, rotation rates, axis of rotation, and shapes. Lightcurve inversion utilizes an asteroid’s change in brightness with respect to phase angle change, which maximizes ground-based observational data. This study investigated the rotational properties of four near-Earth asteroids (NEAs) with a single pole solution and convex shape model of (25330) 1999 KV4 using the lightcurve inversion method. Photometric observations were remotely obtained using the Skynet Robotic Telescope Network, andNOIRLAB’s Cerro-Tololo Inter-American Observatory’s (CTIO) 24” Ritchey-Chretien Prompt 3 Telescope. The data were calibrated using AstroImageJ software, and lightcurve analyses were performed using …

Nanoscale Frictional Properties Of Two-Dimensional Snse And Snse2 With Lateral Force Microscopy, Thomas Iken

Theses and Dissertations

In this study, we employed an atomic force microscopy-based lateral force microscopy technique to examine the nanoscale frictional characteristics of 2D SnSe and SnSe2 layers, and we compared these results with those of graphene, a commonly used solid lubricant. Our results revealed that both SnSe and SnSe2 layers exhibited superior lubricative performance compared to graphene with similar thicknesses. Experimental results were further substantiated by extensive Density Functional Theory calculations to understand the observed frictional properties of these materials.

Cisplatin-Induced Nephrotoxicity And Adaptive Responses In Renal Progenitor Cells: Molecular Insights From Transcriptomic And Proteomic Analyses, Eloho Ighofose

Theses and Dissertations

Cisplatin is a widely used chemotherapeutic agent known for its efficacy against various solid tumors, but its clinical utility is limited by dose-dependent nephrotoxicity. The renal proximal tubule, particularly its epithelial cell population, is highly susceptible to cisplatin-induced injury due to its role in solute transport and high metabolic activity. Recent advances suggest that renal progenitor cells play a key role in epithelial repair following nephrotoxic injury; however, the molecular mechanisms underlying their response to cisplatin remain poorly understood.This study investigates the impact of both acute and chronic cisplatin exposure on immortalized human renal progenitor cells (HRTPT, CD24⁺/CD133⁺) using a …

The Wicked Problem Of Moral Distress: Exploring The Experiences Of Rural Clinic Nurses, Sydney Rae Johnson

Theses and Dissertations

Background: Moral distress is an occupational hazard for nurses that can negatively impact nurses, patients, and the healthcare system. Moral distress has been well documented in high-risk care environments. Each nursing care environment has its own unique triggers for moral distress, but these triggers are unknown in rural clinic nurses. Design and Purpose: This convergent mixed methods study sought to gain a broader understanding of moral distress in nurses working in rural clinic settings.

Methods: Convergent mixed methodology was used to gain a broader understanding of moral distress in nurses working in rural clinic settings. Following ethical approvals, informed by …

Thermally Induced Evolution Of The Cement Microannulus In Co2 Injection Wells, Jawad Ali Khan

Theses and Dissertations

Ensuring wellbore integrity during CO₂ injection is a critical challenge in Carbon Capture and Storage (CCS), as failures at the casing-cement and cement-formation interfaces can create potential leakage pathways. This dissertation presents a multi-scale, physics-based investigation into well integrity risks, integrating finite element analysis (FEA), thermal-mechanical-poroelastic modeling, and transient stress analysis to evaluate cement sheath stability, fracture-driven stress localization, and microannulus formation under various CCS conditions.

A key novelty of this research is the development of a fully coupled thermal-mechanical-poroelastic FEA framework using COMSOL Multiphysics, a renowned industry-standard software for multiphysics simulations. This model enables a dynamic, time-dependent assessment …

Attributions Of Blame In Cases Of Stealthing, Shane William Knutson

Theses and Dissertations

Nonconsensual condom removal (NCCR), also known as “stealthing”, is a form of sexual abuse where an individual removes the condom without their sexual partner’s knowledge. While research regarding prevalence of NCCR has been conducted over the past decade, there are still aspects of previous research on other forms of sexual abuse that did not account for cases of NCCR. One such gap in the current literature are studies that investigate how individuals attribute blame to the victims of NCCR. Previous research has shown that there are differences in how individuals attribute blame towards victims of sexual abuse based on different …

A Qualitative Study Exploring Best Practices And Applications Of Green, Eco, And Environmental Social Work In Canadian Social Work Practice, Ryley Kristanne Kowalski

Theses and Dissertations

Humanity and society are deeply connected to nature and the environment at their core. Through processes of colonization, the Industrial Revolution, urbanization, consumerism, and capitalism, people and societies have become increasingly disconnected from the natural environment. Introduced as a helping profession through the Industrial Revolution, social work began rooted in environment but quickly changed to understand human and societal wellbeing through the narrow scope of the social environment through the person-in-environment approach. Modern day issues of climate change, environmental degradation, environmental racism, and environmental justice movements have necessitated social work’s increased understanding of the natural environment. The purpose of this …

Predicting Social Media Addiction: The Influence Of Paralinguistic Digital Affordances And Cognitive Processes On Social Media Use, Dakota Krebs

Theses and Dissertations

Social media has become an increasing staple in everyday life for numerous people. Yet, excessive and repetitive social media usage may become problematic, to the extent that the behavior takes the form of a psychological addiction. The primary objective of this study was to explore prospective factors that could predict the psychological dependency on social media applications, characterized as social media addiction (SMA). Paralinguistic Digital Affordances (PDAs) are “likes” one receives on social media and may predict SMA via the expected gratification attained when a PDA is received. Cognitive processes, assessed with a general executive functioning index and the n-back …

Thresholds In Modular Lattices, Daniel Atta Kwakye

Theses and Dissertations

This study investigates threshold phenomena in infinite modular lattices, extending classical threshold theory beyond Boolean and distributive lattice settings. Specifically, let\(P\) be a finite graded modular lattice with a finite graded modular lattice with rank function \(r: P \rightarrow \mathbb {N}\). By adapting probabilistic combinational methods, notably the methods used by Janson, Łuczak, and Ruciński (2011), we establish rigorously that every monotone property \(F\subseteq P\) possesses a threshold under the chain-uniform random model.Formally, this threshold is characterized by a critical rank \(M^*\), at which the probability \(\mathbb{P}(\Gamma_M\in F)\) transitions sharply from nearly 0 to nearly 1 as the parameter \(M\) …

Studentification And Off-Campus Housing: A Case Study Of Grand Forks Near-Campus Neighborhoods, Alva Lindstroem

Theses and Dissertations

With national trends in higher education experiencing dwindling enrollments and personal economies increasingly strained, the University of North Dakota (UND) has grown to become the biggest public higher education institution in North Dakota, having effectively bounced back from the COVID-19 pandemic drop in enrollment. Grand Forks, North Dakota, is the host of UND and home to a student body of over 14,000 as of 2023 fall semester. This study focuses on; to what extent is studentification taking place in Grand Forks, ND; and how the observed housing- and demographic patterns in Grand Forks align with, or diverge from, the broader …

White Paper For Faculty Professional Development In Establishing, Addressing, And Informing, To Promote Mental Wellness For Health Careers Students, Betty J. Mcvay

Theses and Dissertations

This research utilized a qualitative case study to explore the need for faculty professional development in the health careers division at a public non-profit California community college, specifically Porterville College. Literature suggests that mental health is a crucial topic to address in contemporary higher education. College students, in general, are facing a notable deterioration in their overall mental well-being, accompanied by an increase in mental disorders. Furthermore, students in health careers programs frequently encounter even more intense stress and psychological challenges, stemming from their constant exposure to high-pressure, emotionally charged situations, and vicarious trauma. Although literature emphasizes the critical need …

Geothermal Sweep Efficiency Enhancement Potential Analysis Using Geological Modeling And Numerical Simulation On Unconventional Deadwood Formation, Ashraf Mohammed

Theses and Dissertations

This study investigates the potential to enhance geothermal sweep efficiency in the fractured, low-permeability Deadwood Formation using a cellulose-based biopolymer and gel treatment. A geological model was developed using well log and structural data from four wells in the Williston Basin and subsequently upscaled into a numerical reservoir simulation in CMG/STARS. Laboratory core-flooding experiments on Deadwood samples were used to calibrate gel behavior under high-temperature (160 °C) and high-salinity (17% TDS) reservoir conditions.Simulation results indicate that a short-duration gel treatment—equivalent to 0.03 pore volumes over one year—can significantly reduce channeling through high-conductivity fractures. The reduction in channeling improves thermal conformance …

Seismic Design And Ductility Evaluation Of Concrete-Filled Thin-Walled Steel Tubular Columns Modeling As Bridge Piers, Njiru Mwaura

Theses and Dissertations

Accurate numerical modeling is essential for evaluating the seismic performance and load-bearing behavior of partially concrete-filled thin-walled steel tubular columns, particularly those used as bridge piers under complex seismic conditions. This study investigates the performance of such columns enhanced with embedded energy-dissipating shell plates and/or partial concrete infill, subjected to unidirectional and bidirectional seismic loading. A validated finite element model (FEM), developed in ABAQUS and incorporating geometric and material nonlinearities—including the modified Two-Surface Model (2SM)—was employed to simulate cyclic behavior and predict structural response.The model was benchmarked against experimental results and used to analyze a broad range of parameters, including …

Why Can't We Just Be: Native American College Student Sense Of Belonging At The University Of North Dakota, Gavin Michael Nadeau

Theses and Dissertations

Sense of belonging is a primary indicator of retention and persistence to graduation forNative American college students. Though more than doubling in the past 30 years, Native American college student enrollment has decreased since 2010 (197,000 in 2010 to 107,000 in 2021) (PNPI, 2021; NCES, n.d.). In 2020, Native American students’ 2nd year retention rate was more than 20% lower than their white peers at the University of North Dakota (UND, 2020). When college students of color feel like they belong, they are more likely to retain, persist, and graduate (Mowreader, 2024; Hurtado & Carter, 1997; Hurtado et al., 1999). …

Evaluating Human Factors In Isolation And Confinement During Analog Spaceflight: A Decadal Survey Assessing Ilmah Crew Psychology, Travis Michael Nelson

Theses and Dissertations

This study examined 13 crews participating in analog Martian surface simulations to investigate psychological experiences within the first collegiate planetary surface habitat. The University of North Dakota (UND) Integrated Lunar-Martian Analog Habitat (ILMAH) was utilized with high-performing participant crews (n=42) who were recognized and recruited for their skills. Common environmental similarities that each crew faced included isolation, confinement, time-latent communications, demanding work hours, monotonous tasks, physically strenuous Extravehicular Activities (EVA), personal psychological adaptations, and interpersonal psychosocial challenges. The primary objective of this study was to evaluate self-appraised crew performance measures across continuous phases of isolation and confinement lasting up to …

When Fomo Meets The Keg: A Descriptive Case Study Of Binge Drinking In First-Year College Students At The University Of North Dakota, Angie Novak

Theses and Dissertations

Binge drinking among first-year college students is a persistent public health and academic issue, particularly during the transition to higher education. As students gain independence and navigate peer influence and campus norms, many perceive alcohol use as a central part of the college experience. This descriptive case study investigates the personal, environmental, and behavioral factors contributing to binge drinking among first-year students at the University of North Dakota (UND).The study, guided by Social Cognitive Theory (SCT), explored how students adopt and reinforce drinking behaviors through peer modeling, social expectations, and institutional culture. Qualitative data was collected through individual interviews with …

Evaluating The Engineering Properties Of Waste-Modified Asphalt Binders And Mixtures As Inputs For The Mechanistic-Empirical Pavement Design, Duncan Rioba Oteki

Theses and Dissertations

Pavements are essential for economic development and mobility, with asphalt dominating the US road network due to its cost-effectiveness, ease of maintenance, and recyclability. However, the environmental impacts of asphalt production and the depletion of virgin materials have driven the integration of waste products into asphalt mixtures to improve sustainability. This study evaluated the engineering properties of waste-modified asphalt binders and mixtures as performance-based inputs for the Mechanistic-Empirical Pavement Design Guide (MEPDG). The rutting performance of ten asphalt mixtures commonly used in North Dakota was assessed using mechanistic and empirical tests. Mechanistic tests included the dynamic modulus (|E*|), Flow Number …

Teacher Skills Needed For Effective Participation In Multi-Tiered Systems Of Support (Mtss): A State Framework Analysis, Melissa Osborne

Theses and Dissertations

This study is a secondary data analysis that uses a validated rubric to score the degree of alignment between the teacher skills (TS) necessary for the effective implementation of Multi-Tiered Systems of Support (MTSS) and the preservice teacher training standards (PTS) across five states located in the North Central United States. This investigation also assessed whether states employing an MTSS process to establish special education eligibility for specific learning disabilities (SLD) exhibit higher alignment between TS and PTS compared to states that do not follow that process. Literature outlines the TS needed in an MTSS framework, but there is limited …

High-Fidelity Surface And Environment Simulation Using Immersive Virtual Reality For Lunar Analog Training, Shriya Pedaparthi

Theses and Dissertations

The study explores the integration of high-fidelity Virtual Reality (VR) into astronaut training for lunar analog missions. A realistic VR simulation was developed to represent lunar terrain, allowing participants to perform critical tasks under simulated lunar conditions. Specifically, participants navigated from a compromised lunar habitat (ILMAH) facing a pressure breach, to a secure facility, testing their ability to respond effectively to emergency scenarios. Participants underwent three sequential trials to assess how VR and physical constraints influence gait and performance: (1) a baseline trial measuring natural gait without equipment; (2) a trial incorporating a real spacesuit and lunar gravity simulated through …

Comparative Study Of Robotic And Manual Welding For Energy Consumption And Efficiency In A High Mix, Low Volume Manufacturing Environment, John Ruprecht

Theses and Dissertations

This study examines the comparative efficiency and energy consumption of manual versus robotic welding in high-mix, low-volume (HMLV) manufacturing environments. Traditional robotic welding systems have been predominantly used in low-mix, high-volume production due to their efficiency in repetitive tasks. However, the advent of collaborative robots (cobots) has democratized robotic automation for diverse manufacturing needs. Cobots allow flexibility in programming, enabling their deployment in HMLV environments characterized by hard product variety and smaller batch sizes. This research evaluates energy consumption, welding speed, and quality metrics across manual and cobotic welding systems. Data were gathered using energy meters and video analysis, focusing …

Nutrition Implications In Hypermobile Ehlers-Danlos Syndrome (Heds)/Hypermobility Spectrum Disorder (Hsd), Lauren Steiner

Theses and Dissertations

Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are a poorly recognized and under researched group of genetic connective tissue disorders that have widespread impacts on the human body, including gastrointestinal (GI) symptoms. The role of dietary and supplemental interventions in GI symptom control in this patient population has not been researched. This study used an exploratory survey to collect data on diets and supplements that the patient population has used to combat GI symptoms. The low histamine, gluten free, dairy free, anti-inflammatory, and intermittent fasting diets, as well as magnesium, probiotic, coenzyme Q10, vitamin C, vitamin B12, and …

Negotiating Gender: A Qualitative Analysis Of Trans-Parasocial Relationships With Gen Z Social Media Users, Hannah Grace Scheffer-Wentz

Theses and Dissertations

The growth of social media and its functions as an online, international forum has been a growing topic of interest for researchers and the public alike. With the rise of native influencing and the incorporation of “organic” advertising, Social Media Influencers have grown in not just following and publicity with affiliate marketing and brand partnerships, but they have grown in social interest, as well. With the rise in technology and the introduction of Gen Z, who are digital natives, this has challenged previous understanding of online relationships, specifically with the expansion of Parasocial Relationship Theory to the online application of …

The Relationship Between Social Determinants Of Health And Maternal Risk Factors With Severe Maternal Morbidity, Rebecca Smith

Theses and Dissertations

Severe maternal morbidity (SMM) remains a significant public health concern in the United States, with rates rising despite advancements in obstetric care. While extensive research has examined the role of clinical risk factors in SMM, less attention has been given to the influence of social determinants of health (SDOH). Factors such as financial insecurity, food access, housing stability, intimate partner violence, social connectedness, and transportation barriers may contribute to maternal health disparities. This study aims to assess the relationship between SDOH and SMM, evaluating how these non-clinical factors shape maternal health outcomes. Additionally, this research explores the impact of maternal …

Eco-Friendly Synthesis Of Anemonin From 5-Hydroxymethylfurfural, A Biomass-Derived Starting Material, Diane Zefack Tangmi

Theses and Dissertations

Anemonin, a valuable cyclobutane containing dilactone is a bioactive natural product from Ranunculaceae plants. It holds great potential for applications in pharmaceuticals and materials science. However, traditional synthesis methods are hampered by low yields, toxic reagents, and environmental concerns, limiting its practical use. This study highlights the development of green and scalable synthetic strategies designed to achieve high yields while minimizing environmental impact. Our approach focuses on sustainable methodologies, including optimized steam and fractional distillation performed under mild conditions to reduce waste and energy demands. Protoanemonin’s natural ability to dimerize under mild heating offers a green approach to anemonin synthesis, …

Experimental And Numerical Modeling For Co2 Utilization In Enhanced Oil Recovery And Associated Storage In Unconventional Reservoirs, Billel Sennaoui

Theses and Dissertations

Unconventional reservoirs, such as the Bakken and Three Forks formations, present significant challenges due to their ultra-low permeability and complex fracture networks, which limit primary oil recovery to less than 10%. To enhance hydrocarbon extraction while simultaneously facilitating carbon dioxide (CO₂) storage, this study investigates the mechanisms governing CO₂ Huff-n-Puff (HnP) and associated storage under various operational conditions. A comprehensive approach integrating experimental analysis, numerical simulations, multiphase flow modeling, and geochemical interactions is employed to optimize CO₂-EOR and storage strategies. The experimental phase focuses on evaluating the performance of different injected gases (CO₂, ethane, and propane) in the Upper Three …

Artificial Intelligence And Machine Learning Models To Increase Colorectal Cancer Detection For American Samoa Adults, Va'atausili Tofaeono

Theses and Dissertations

Colorectal cancer (CRC) remains a leading cause of morbidity and mortality among Indigenous and Pacific Islander populations, particularly in American Samoa, where screening rates are critically low due to cultural barriers, limited healthcare infrastructure, and geographical isolation. This dissertation explores the potential of an Artificial Intelligence and Machine Learning (AI/ML) predictive model to enhance CRC screening and early detection among American Samoan adults. By leveraging widely available clinical data, such as complete blood count (CBC) results, age, and gender, the AI/ML model aims to identify high-risk individuals for targeted interventions, thereby improving early detection and treatment outcomes.The dissertation comprises three …

Addressing The Impact Of Unlicensed And Under-Licensed Teachers In Pk-12 Schools: How School Administrators Offer Support, Taylor Topinka

Theses and Dissertations

As the impact of the teacher shortage grows, more teachers are entering classrooms with incomplete teacher licensure. Related literature affirms that new-to-profession teachers experience what Danielson (1999) described as a “sink or swim in the deep end of the pool” culture as they attempt to navigate the beginning of their teaching career with an incomplete license or no license entirely (p. 251). The influx of partially-licensed teachers engaging students is a dilemma created by the growth of the teacher shortage. The purpose of this study was to address the impact of unlicensed and under-licensed teachers on student growth and achievement …

Stem Professors’ Motivation To Engage In A College Teaching Certificate, Justin Craig Alexander

Theses and Dissertations

Despite an expanded focus on educating students in STEM disciplines, nearly half of U.S. college students who enroll in these degree programs fail to graduate (Hamm et al., 2020, p. 623). Critics sometimes blame pedagogically untrained faculty (e.g., Kahn, 2022). This Dissertation in Practice (DiP) focused on STEM university faculty's motivation for teaching and whether professors are motivated to enroll in pedagogy courses. Via the lens of self-determination theory (SDT), this DiP examined to what extent STEM faculty at a major research university in the upper Midwest could devote additional time to pedagogy by enrolling in a college teaching graduate …