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Feeding- And Light-Cycle Synergistically Regulate Mouse Blood Pressure Daily Rhythm Via Bmal1-Dependent And Independent Mechanisms, Tianfei Hou, Wen Su, Aaron Chacon, An-Hsuan Lin, Zhenheng Guo, Ming C. Gong

Physiology Faculty Publications

Cardiovascular health requires the orchestration of the daily rhythm of blood pressure (BP), which responds to changes in light exposure and dietary patterns. Whether rhythmic light and feeding can modulate daily BP rhythm directly or via modulating intrinsic core clock gene Bmal1 is unknown. Using inducible global Bmal1 knockout mice (iBmal1KO), we explored the impact of rhythmic light, rhythmic feeding, or their combination on various physiological parameters. Daily rhythms of BP, heart rate, and locomotor activity were monitored via radiotelemetry, while food intake patterns were tracked using the BioDAQ system. Respiratory exchange ratio (RER) and energy expenditure (EE) were assessed …

Differential Plasma Carotenoid Profiles In Hypertensive Disorders Of Pregnancy, Colman Freel, Jonah Scheffler, Rebecca Drakowski, Elizabeth Lyden, Matthew Van Ormer, Melissa K. Thoene, Paras K. Mishra, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

Background: Hypertensive disorders of pregnancy (HDP) affect one in six pregnancies globally. The etiology of HDP remains unclear but is known to involve oxidative stress. While the body produces endogenous antioxidants, antioxidative nutrients, like carotenoids, remain critical in modulating oxidative stress. The statuses of several carotenoids have been linked to hypertension in both pregnant and non-pregnant populations. However, their associations with the spectrum of HDP, including gestational hypertension (GH), chronic hypertension (CH), and preeclampsia (PE), remains unclear. Our objective was to quantify and compare carotenoid intake and plasma levels among HDP. Methods: We conducted a prospective cohort study …

Discovery Of Plant Secondary Metabolism Through Computational And Synthetic Biology Technologies, Shenqi Wang

Yale Graduate School of Arts and Sciences Dissertations

Plants have evolved to produce a myriad of secondary metabolites, which have been a rich source of small molecules with numerous applications in modern medicine. However, many therapeutic small molecules still rely on plant sources for their production and confront various challenges such as low purification efficiency, slow growth of plants, and the scarcity of species. Advances in synthetic biology have created alternative opportunities to overcome these challenges by producing valuable plant natural products through heterologous expression of the biosynthetic pathways in microorganisms. However, the biosynthetic pathways of many plant natural products remain poorly understood due to inaccurate gene annotations …

Methylome–Proteome Integration After Late-Life Voluntary Exercise Training Reveals Regulation And Target Information For Improved Skeletal Muscle Health, Toby L Chambers, Andrea Dimet-Wiley, Alexander R Keeble, Amin Haghani, Wen-Juo Lo, Gyumin Kang, Robert Brooke, Steve Horvath, Christopher S Fry, Stanley J Watowich, Yuan Wen, Kevin A Murach

Physiology Faculty Publications

Abstract: Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of exercise on muscle in a preclinical setting, we developed a combined endurance–resistance training stimulus for mice called progressive weighted wheel running (PoWeR). PoWeR improves molecular, biochemical, cellular and functional characteristics of skeletal muscle and promotes aspects of partial epigenetic reprogramming when performed late in life (22–24 months of age). In this investigation, we leveraged pan-mammalian DNA methylome arrays and tandem mass-spectrometry proteomics in skeletal muscle to provide detailed information on late-life PoWeR adaptations in female mice relative to age-matched sedentary controls (n = 7–10 …

Inter-Rater Reliability Of Muscle Ultrasonography Performed By Multidisciplinary Novice Sonographers In The Evaluation Of Critically Ill Patients With Acute Kidney Injury Requiring Continuous Kidney Replacement Therapy, Felipe González-Seguel, Vinh Q. Tran, Chaitanya Anil Pal, Zan T. Shareef, Hayley P. Israel, Arimitsu Horikawa-Strakovsky, Yuan Wen, Benjamin R. Griffin, Javier A. Neyra, J. Pedro Teixeira, Kirby P. Mayer

Physiology Faculty Publications

Early diagnosis of muscle wasting in critically ill patients with acute kidney injury requiring continuous kidney replacement therapy (AKI-CKRT) may improve outcomes via timely rehabilitation and nutrition. Muscle ultrasound (MUS) has recently gained traction for assessing muscle atrophy in the intensive care unit (ICU) but requires training to achieve reproducibility. We evaluated the inter-rater reliability of MUS in patients with AKI-CKRT performed by multidisciplinary raters including nephrologists. Two blinded independent raters used portable ultrasound to acquire images of the rectus femoris (RF). All raters were clinicians routinely caring for patients with CKRT in the ICU and were initially novices in …

Skeletal Muscle Stem Cell Mitochondria Are Transferred To Muscle Fibers In Response To A Hypertrophic Stimulus, Jensen Goh, Julia G. Williams, Sarah E. Ogle, Jai K. Joshi, Logan N. Scott, Benjamin Burke, Alex R. Keeble, Nicholas T. Thomas, Christopher S. Fry, Ahmed Ismaeel, John J. Mccarthy

Physiology Faculty Publications

The fusion of skeletal muscle stem cell (MuSC) to myofibers during hypertrophy has exclusively focused on the transfer of the MuSC nucleus, leaving the fate of other MuSC organelles, such as mitochondria, largely unexplored. The objective of this study was to determine whether MuSCs transfer their mitochondria upon myofiber fusion in response to a hypertrophic stimulus. To achieve this goal, we specifically labeled MuSC mitochondria with Dendra2 fluorescence by crossing the MuSC-specific CreER (Pax7^CreER/CreER) mouse with the Rosa26-Dendra2 mouse to generate the Pax7-Dendra2 mouse. To induce the fusion of MuSC to myofibers, Pax7-Dendra2 mice underwent synergist ablation surgery …

Association Of Social Support And Burnout Among Undergraduate Medical And Health Sciences Students At A Malaysian University, Lee Jia Le, Farrah Asyiqin Mansor, Kayalvili R. Manogar,, Siti Khadijah Adam

Health Professions Education

Purpose: Medical and health sciences students are prone to burnout due to intense academic pressure and demanding schedule. Social support plays a vital role in mitigating burnout by providing emotional, informational, and practical assistance, which helps students navigate the challenges of their rigorous academic environment. The aim of this study was to determine the prevalence of burnout and the contributing factors among these students in a university in Malaysia. The association between social support and burnout among these students was also explored.

Method: A cross-sectional study was conducted among 459 undergraduate students in the Faculty of Medicine and Health Sciences, …

Hormonal Decay After Death: Evaluating Dhea-S As A Potential Molecular Marker For Postmortem Estimation, Marisa Lydia Novak

Graduate Student Theses, Dissertations, & Professional Papers

Post-mortem interval (PMI) estimation is a central component of forensic anthropological investigation, but traditional methods for estimating time since death lose accuracy after ~72 hours. Recent research indicates that some steroid hormones may undergo predictable degradation patterns after death, offering potential use as biochemical clocks for PMI estimation beyond this threshold. Dehydroepiandrosterone (DHEA), and its sulfate form (DHEA-S) are of particular interest due to their metabolic stability, systemic influence, and association with trauma. This study investigates whether DHEA-S hormonal degradation patterns correlate with time elapsed since death and body temperature, evaluating their potential as biochemical PMI markers. 160 mL of …

Big Cells, Big Impact: Unravelling Seasonal Patterns Of Net Primary Production In Narragansett Bay, Dominique Jae Lockwood

Open Access Master's Theses

Net primary production is a measurement of available energy, or the amount of biomass that phytoplankton produce during photosynthesis that fuels marine food webs and drives carbon cycling. Despite its ecological importance, net primary production is relatively understudied in comparison to chlorophyll-a, which is often used as a proxy for biomass rather than productivity. In this study, we measured size-fractionated net primary production and chlorophyll-a concentrations in Narragansett Bay over a 14-month period from January 2022 to February 2023. Weekly surface water samples were collected and filtered to distinguish between small (> 10 μm) and large ( …

Associations Between Dietary Sodium And Potassium Intakes, Urinary Sodium And Potassium Excretion And Blood Pressure Among Adult Females In Oromia Region, Ethiopia, Fred Baffour Addo

Open Access Master's Theses

Introduction: Accurate assessment of sodium (Na) and potassium (K) intake is essential for population level monitoring of salt intake as part of global strategies to reduce salt consumption to control the increasing prevalence of high blood pressure (BP). Thus, a simple, cost-effective, and low-burden method is particularly valuable in resource-limited settings for population level monitoring of Na and K intake. This study aimed to compare the reliability of various methods of Na and K intake assessment, and their associations with blood pressure measurements.

Methods: This secondary analysis was based on a cross-sectional study of 100 non-pregnant women of …

Estrogen Receptor-Mediated Effects Of Resveratrol On Muscle Function, David Ayi-Bonte

Open Access Master's Theses

Artemis missions are set to send the next man and the first woman back to the moon and enable long-term missions on the lunar surface. However, exposure to lunar gravity has significant physiological effects characterized by loss of muscle mass, weakness and decreased bone density. Nutraceutical countermeasures such as Resveratrol (RSV), a naturally occurring polyphenol, have been identified as promising strategies to preserve musculoskeletal health; however, its pleiotropic effect hinders our ability to identify the primary cellular pathways through which it delivers its benefits. Furthermore, its efficacy in simulated lunar gravity is unknown. Based on the benefits observed with RSV …

“Democracy,” Usa, Marc Edelman

Publications and Research

What does it mean to be an effective citizen in a democracy? Answering this question requires unpacking “democracy” and an analysis of institutions that systematically disempower and alienate citizens. This paper briefly examines the contributions of psychoanalysis to understanding democracy and authoritarianism. It scrutinizes U.S. governance institutions and points to democratic deficits and backsliding present even before Trump 1.0 and 2.0. These range from the Electoral College, the Senate, and the Supreme Court to the Federal Communications Commission. All contributed to institutionalizing minority rule and elite capture. Governance institutions failed to deliver what the American people tell opinion pollsters they …

Butyrate Attenuates High-Fat Diet Induced Glomerulopathy Through Gpr43-Sirt3 Pathway, Ying Shi, Lin Xing, Ruoyi Zheng, Xin Luo, Fangzhi Yue, Xingwei Xiang, Anqi Qiu, Junyan Xie, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications

The incidence of obesity related glomerulopathy (ORG) is rising worldwide with very limited treatment methods. Paralleled with the gut-kidney axis theory, beneficial effects of butyrate, one of short-chain fatty acids produced by gut microbiota, on metabolism and certain kidney diseases have gained growing attention. However, the effects of butyrate on ORG and its underlying mechanism are largely unexplored. In this study, a mice model of ORG was established with high-fat diet (HFD) feeding for 16 weeks, and sodium butyrate treatment was initiated at the 8th week. Podocytes injury, oxidative stress, and mitochondria function were evaluated in mice kidney and validated …

Records Of The Wilmore Day Care Center Arc 2025-005 - Finding Aid, Ats Special Collections And Archives

Finding Aids

No abstract provided.

Annual Report, Associated Charities, Memphis, 1932

Documents

Annual Report of the Associated Charities, Memphis, TN. It covers the year of 1932.

Correspondence And Documents, Family Welfare Agency, Memphis, 1939

Documents

A grouping of correspondence and blank cards. The correspondence is to the Family Welfare Agency, Memphis, TN, on 1939 December 5 from the Family Welfare Association of America, New York, NY. They were asking the Family Welfare Agency in Memphis for feedback on cards that the agencies in membership with the Family Welfare Association of America were able to order. Included is the response from Leora L. Conner, General Secretary, of the Family Welfare Agency, Memphis, TN, on 1939 December 7.

Correspondence And Documents, Family Welfare Agency, Memphis, 1939

Documents

A grouping of documents including correspondence, blank forms, and blank cards. The correspondence is to the Family Welfare Agency, Memphis, TN, on 1939 October 25 and 1939 November 16, from the Family Welfare Association of America, New York, NY. They were asking the Family Welfare Agency in Memphis for feedback on forms and cards that the agencies in membership with the Family Welfare Association of America were able to order.

2024 Quality Assessment And Performance Improvement Strategy Update, Tennessee. Division Of Tenncare.

TennCare Additional Reports

No abstract provided.

Smart Goal-Setting On Behaviors To Enhance Intrinsic Motivation For Exercise: A Pilot Study With Orangetheory Fitness Participants, Adam Relitz

Williams Honors College, Honors Research Projects

Abstract

PURPOSE: Sustaining long-term motivation for exercise remains a challenge within health and fitness, particularly when extrinsic factors like weight loss dominate motivational strategies. This study investigates the role of behavioral SMART (Specific, Measurable, Achievable, Relevant, Time-bound) goal-setting in fostering intrinsic motivation, a self-driven form of engagement, among participants in a structured fitness program. The primary aim was to evaluate the effectiveness of a SMART goal-setting curriculum in promoting intrinsic motivation and behavior-based goals over external outcomes like losing weight. METHODS: Participants (N = 24) were recruited from a fitness challenge program and selected one behavioral SMART goal from a …

Indirect Calorimetry: The Effects Of Overfeeding And Underfeeding Mechanically Ventilated Patients, Hailee Schirm

Williams Honors College, Honors Research Projects

This research focuses on the effects of overfeeding and underfeeding mechanically ventilated patients in the ICU and how indirect calorimetry plays a role in improving patient outcomes. Research was pulled from eight peer reviewed sources written within the last ten years to support this statement. It includes multiple types of studies including but not limited to a retrospective cohort study, meta-analysis, review, and deterministic cost-sequences analysis. Indirect calorimetry measures carbon dioxide production and oxygen consumption to calculate energy expenditure and determine the number of calories needed to sustain one’s body. This allows us to determine the number of calories a …

Hip Strengthening In Female Collegiate Soccer Players: Effects Of Gluteus Medius Strengthening On Biodex Balance Scores, Caitlin Bruni, Morgan Shansky

Williams Honors College, Honors Research Projects

The purpose of this study is to examine the effects of gluteus medius (Gmed) strengthening program on single leg stability in collegiate female soccer players. Given the role of Gmed in stabilizing the hip, improving its strength may reduce lower extremity injury risk. Weakness in Gmed has been linked to conditions such as Anterior Cruciate Ligament (ACL) tears and Patellofemoral pain syndrome (PFPS). This study investigates whether an 8-week strength program improves single-leg stability, measured using the Biodex Balance System. Thirty-three female soccer players (18-23 years) from The University of Akron were recruited, with 22 completing the study. Participants underwent …

Critical Analysis Of Gestational Diabetes Risk Factors: A Systematic Review, Madison Keich, Madeleine Ray, Mia Ross

Williams Honors College, Honors Research Projects

Gestational Diabetes Mellitus (GDM) is a common complication of pregnancy that causes an increased blood sugar that can affect both the mother's and baby’s health. A variety of factors can increase the risk of developing the disease, including race, socioeconomic status, and prenatal education. Each of these factors contributes to the experience of one’s maternal care. Expecting mothers may not understand how significant GDM is, and its potential to result in negative outcomes. It is important to review these factors, acknowledge them, and help reduce health disparities caused by them. Nurses are vital to assessing and delivering patient education on …

Effects Of Exercise On Cognitive Performance, Autumn Bailey

Williams Honors College, Honors Research Projects

This research project “Effects of Exercise on Cognitive Performance” will be conducted with the purpose of determining the relationship between exercise and cognitive performance. The relationship between injury and cognitive performance will also be investigated. In order to investigate these relationships 60 participants who are current students at the University of Akron will be asked to complete three cognitive assessments, one while at rest, one while riding an exercise bike, and one following the completion of exercise. The results of these three assessments will be compared to determine the relationship between cognitive performance in all three states. Participants will include …

Review Of Research On Relative Energy Deficiency In Sport (Red-S), Paige Mcmaster

Williams Honors College, Honors Research Projects

The following research article review serves to summarize and evaluate peer-reviewed research articles on the topic of Relative Energy Deficiency in Sport (RED-S). The paper will cover RED-S's effect on males versus females, endurance athletes versus non-endurance athletes, recreational athletes versus competitive athletes, and different age groups. Methodology includes strategically reviewing current literature and providing common themes or key points. The goal is to effectively summarize the subject of RED-S, provide in-depth understanding of the condition, and establish the need for education to prevent or reduce the incidence of RED-S.

The Social Construction Of Homelessness: A Qualitative Examination Of International Efforts To Address Homelessness, Chanel Swoope

Theses and Dissertations

Homelessness is a multi-layered worldwide issue, shaped by cultural, economic, and political factors. This qualitative case study compared two international non-profit organizations, Hope Haven in Paraguay and Safe Shelter Foundation in Finland, in their approaches to reducing homelessness. The research explores how institutional systems and sociocultural norms shape intervention by utilizing two theoretical frameworks, structural functionalism and social constructionism. The study included semi-structured interviews with twelve participants employed by the organizations, seven from Paraguay and five from Finland, and a review of archival program data. The interview and archival data were triangulated with deductive and inductive data analysis.

Findings revealed …

Exploring The Perceptions And Experiences Of School Building Leaders At Public Charter Schools And The Impact They Have On The Provision Of Physical Education In Charter School Settings, Nathaniel Bouie Jr.

Theses and Dissertations

This qualitative phenomenology study aimed to explore the perceptions of school principals regarding physical education (PE) and its impact on school programming. Semi-structured interviews were conducted with ten school principals in an urban charter school district in the United States. The interviews were transcribed, and data were analyzed using the phenomenological approach under the lens of teacher socialization.

The findings of the study revealed that physical education was perceived as an inferior subject compared to core subjects such as mathematics, science, and language arts. School leaders viewed PE as less important than other subjects and often reduced its instructional time …

A Systematic Review Of The Outcomes And Efficacy Of Complementary And Alternative Non-Pharmacological Interventions In Youth With Attention Deficit Hyperactivity Disorder, Kelly M. Kohler

Theses and Dissertations

A number of behavioral and pharmacological treatments have been widely accepted as evidenced-based approaches to treating symptoms of attention-deficit hyperactivity disorder (ADHD) in children and adolescents. While pharmacological approaches are safe and effective at managing symptoms, a large subset of caregivers do not have access to medication, refuse it, or find it ineffective, necessitating the need for non-pharmacological treatments. Such behavioral interventions are also generally effective approaches to symptom management and reducing the functional impairment of ADHD and may even demonstrate better parent satisfaction than medication alone. However, these interventions are often difficult to access and burdensome to implement, especially …

The Role Of Fruiting Bodies In Protecting A Community Of Myxococcus Xanthus Spores From The Environment, Dave Lall

Wayne State University Dissertations

Environmental microorganisms have evolved a variety of strategies to survive fluctuations in environmental conditions, including the production of biofilms and differentiation into spores. Myxococcus xanthus are ubiquitous soil bacteria that produce starvation-induced multicellular fruiting bodies filled with environmentally resistant spores (a specialized biofilm). Isolated spores have been shown to be more resistant than vegetative cells to heat, ultraviolet radiation, and desiccation. The evolutionary advantage of producing spores inside of fruiting bodies is not clear. Here, we examine a hypothesis that the fruiting body provides additional protection from environmental insults. We developed a high-throughput method to compare the recovery (outgrowth) of …

Environmental Pollution And Early-Life Metabolic Programming, Lisa Koshko

Wayne State University Dissertations

Substantial evidence demonstrates that parental pollutant exposures can induce harmful health effects in the offspring, including the predisposition to Type II Diabetes. As rates of Type II Diabetes continue to rise in younger populations, a crucial gap lies in understanding the role of parental influence in the etiology of later-life metabolic disease. Therefore, the central goal of this work was to determine how early life exposure to smoking level benzene, an endocrine-disrupting air pollutant, affects the metabolic health of offspring, and to identify potential developmental mechanisms involved in disease susceptibility. This goal was achieved using two models of early life …

Proceedings Of The Tenth Annual Indiana Stem Education Conference: Generational Advances Through Stem Education, William S. Walker Iii, Lynn A. Bryan, S Selcen Guzey

Indiana STEM Education Conference

The Proceedings of the Tenth Annual Indiana STEM Education Conference are edited by the Center for Advancing the Teaching and Learning of STEM (CATALYST, https://www.education.purdue.edu/catalyst/) at Purdue University. The theme for the 2025 conference is Generational Advances through STEM Education. This year’s conference provides opportunities to learn about effective STEM education strategies, curriculum, and resources to engage students by considering the advances and impact of STEM.