Digital Commons Network^™

Longitudinal Changes In Verbal And Nonverbal Memory Among Older Adults: The Relevance Of Demographic Variables, Lauryn Owen

Electronic Theses and Dissertations 2020 - Present

The study investigated longitudinal changes in verbal and nonverbal memory among older adults, examining the influence of demographic variables (age, sex, and education), memory associations with cognitive screening performance over time, and short-term practice effects. Linear mixed-effects models and repeated measures ANCOVAs were used to evaluate memory change over time and determine which memory tests were more susceptible to practice effects. Memory was assessed using subscales from the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), Craft Story 21 (CS), and the Benson Complex Figure Test (BCFT). Results showed that age and sex were significant predictors of verbal memory, with …

Wellness Among Bipoc Counselors-In-Training: Mediation Impact On Stress And Burnout, Javier E. Ponce

Electronic Theses and Dissertations 2020 - Present

The purpose of this research study was to gather data on stress, wellness, and burnout levels from counselors-in-training (CITs) who identify as Black, Indigenous, and people of color (BIPOC) to compare them to norm groups and assess the mediating effect of wellness on the association between stress and burnout. The researcher conducted this study to aid counselor educators in incorporating wellness into interventions that can help BIPOC CITs not only reduce their stress and burnout levels but also augment their overall wellness. The final sample consisted of 118 BIPOC CITs who thoroughly completed a demographic questionnaire, Perceived Stress Scale-10, Five …

The Impact Of The Imsd Mentorship Program On Stem Doctoral Graduation Rates: An Application Of Elite Theory, Kristen Alexandria Walden

Electronic Theses and Dissertations 2020 - Present

Disparities in doctoral STEM completion rates among underrepresented groups raise questions about institutional power and access in higher education. This dissertation investigates graduation rates among minority doctoral students in science, technology, engineering, and mathematics (STEM) fields, comparing results at public and private universities through the lens of elite theory. Elite theory asserts that power is concentrated within small groups or institutions that influence national and institutional outcomes. Although public administration literature addresses elite power structures in universities, less research has examined how these dynamics influence graduation for underrepresented groups in doctoral STEM disciplines.

This study applies elite theory to explore …

Does Exclusive Breastfeeding Duration And Quality Affect Maternal Sensitivity: Fear Vs. Normative Situations, Camila Herrera Zamora

Electronic Theses and Dissertations 2020 - Present

The present study examined whether exclusive breastfeeding duration and perceived breastfeeding quality predict maternal sensitivity across emotionally challenging versus normative caregiving contexts in infancy. Twenty-four mother–infant dyads participated in three laboratory visits during which maternal sensitivity was assessed across interaction conditions. It was hypothesized that (1) longer breastfeeding duration would be associated with greater sensitivity during fear-inducing contexts, (2) breastfeeding duration and quality would interact to predict sensitivity, and (3) sensitivity would be higher during fear-inducing situations. Contrary to expectations, maternal sensitivity was highest in the normative/free-play condition and increased over time, peaking at 14 to 16 months. Exclusive breastfeeding …

A Computational Approach For Intramural Length Estimation In Anomalous Aortic Origin Of A Coronary Artery, Tam T Doan, Shagun Sachdeva, Craig G Rusin, Dan Lior, Charles Puelz, Prakash M Masand, Silvana Molossi

Faculty, Staff and Students Publications

Introduction: Anomalous aortic origin of a coronary artery (AAOCA) is associated with sudden cardiac death. The intramural (IM) length is considered high-risk, yet radiologic measurements by computed tomography angiography (CTA) show variable agreement with measurements at surgery. We aimed to develop a semi-automatic computational method to estimate IM length in a retrospective cohort of surgical AAOCA patients.

Methods: In 58 patients [49 right(R), 9 left(L)], CTA images were used to generate 3D segmentations of the aorta and a centerline of the anomalous coronary. The distance from the centerline to the aortic segmentation was calculated. The IM length was estimated from …

Incorporating Individually Defined Brain Health Priorities In Clinical Trial Outcomes: The Electronic Person-Specific Outcome Measure Approach In The United States, Claudio Toro-Serey, Sean Tobyne, Killian Mcmanus, David Bates, John Showalter, Álvaro Pascual-Leone

Faculty, Staff and Students Publications

Introduction: While a limited number of disease-modifying treatments for Alzheimer's disease (AD) have been approved in the United States, there is caution in adopting these treatments in clinical use. The electronic Person-Specific Outcome Measure (ePSOM) tool was recently developed to establish whether, besides modifying underlying AD pathology, new treatments exerted sufficient beneficial effects in areas that matter the most to an individual.

Methods: We conducted a study to understand how findings from the ePSOM UK study applied in the United States. The ePSOM US survey (May 2023 to January 2024) collected primarily free-text responses in personally defined brain health priorities, …

Introducing The Special Series “Sound History Is Cultural History”, Josh Shepperd, Amanda R. Keeler

College of Communication Faculty Research and Publications

This special series features the collaborative work of the Library of Congress Radio Preservation Task Force. The task force is a national clearinghouse project that brings together researchers from academic, archival, federal, and commercial sectors. Pieces in the series discuss RPTF participant commitments and strategies regarding the preservation and curation of the cultural history of sound. The first pieces in the series feature the research of three media historians, who discuss new directions for assessing radio as a cultural and political medium, in reference to the materiality of radio recordings as historical artifacts.

The Drivers Of Corporate Political Engagement, Steven K. May, Katharine E. Miller

College of Communication Faculty Research and Publications

No abstract provided.

Creation Of A Dual-Fluorescence Reporter System To Assay Mirna Regulation Of Apobec3a, Tolulope D. Ajayi

All Graduate Theses, Dissertations, and Other Capstone Projects

MicroRNAs have an important role in regulating gene expression, including regulating the transcripts of the APOBEC3 family of cytidine deaminases. The APOBEC3 family is part of the immune defense against viral infection but has also been implicated in cancer progression. The hypothesis for this thesis is that specific miRNAs could be identified that regulate APOBEC3A (A3A) expression. I used molecular cloning and confocal microscopy to evaluate the miRNA-mediated silencing of A3A. A commercially available vector, psiCHECK-2, can be used to assay microRNA (miRNA) activity on specific targets. Molecular cloning was performed to modify the psiCHECK-2 Dual luciferase system (Renilla and …

The Rhythm Of Resistance: Marginalized Bodies And Dominant Rhythmic Systems, Bilan Mire

All Graduate Theses, Dissertations, and Other Capstone Projects

All human beings are perceptive entities, engaging with the world through somatic and sensory experiences. These interactions allow individuals to assess, understand, and navigate their surroundings and social contexts. Our bodies, through daily experiences and interactions with the constructed environment, learn to move in harmony with or in opposition to dominant societal rhythms. However, it would be inaccurate and misleading to claim that all individuals can seamlessly synchronize with these societal rhythmic systems. For bodies marginalized by race, gender, age, disabilities, and other factors are policed, stigmatized, minimized, and enclosed, resulting in an inability for marginalized individuals to fully synchronize …

In Praise Of Dust, Hasler Gomez-Perez

Theses and Dissertations

A desire path is a physical manifestation of where a system has failed, but also where it has been refused, where a new path has been made. The wake exists in the post, it is not a singular, untethered event, but a subtle double entendre that lives in the post-death, but also in the pre-life—not a liminal limbo, but a superposition of dying and waking.

This collection was assembled and composed over the course of two years as I navigated my practice, myself, and others. Present here are my thoughts, my experiences, and in many ways my beliefs. IN PRAISE …

Testing The Antigenic Potential Of Transmembrane Proteins To Develop A Thermostable Tuberculosis Mof-Liposomal Vaccine, Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis is one of the deadliest infectious diseases and continues to be a major health risk in many parts of the world. Even today, the century-old Bacillus Calmette-Guerin (BCG) vaccine is the only formulation on the market and is ineffective for several sections of the global population responsible for transmission. In the search for antigens that can mount a robust immune response, we have reported the recombinant expression and purification of two novel membrane proteins, the Cation transporter protein V (CtpV) and the Mycobacterial copper transporter B (MctB) present on the membrane surface of Mycobacterium tuberculosis. CtpV was tested …

From Misinformation To Policy Solutions: Teaching Herd Immunity And Vaccine Hesitancy Through Real-World Case Studies Of Measles Outbreaks, Laurieann Klockow

Biomedical Sciences Faculty Research and Publications

Vaccine hesitancy threatens herd immunity, contributing to the resurgence of measles outbreaks. This lesson engages upper-level biomedical science students in analyzing the complex interplay between vaccination rates, herd immunity and vaccine exemption policies through examination of the 2019 New York measles outbreak that threatened the United States’ measles elimination status. Students critically evaluate anti-vaccine misinformation, analyze epidemiological data and develop evidence-based policy recommendations to increase vaccination rates. The lesson combines team-based learning with authentic assessment through vaccine policy development, moving beyond knowledge acquisition and content to building scientific literacy and evidence-based reasoning skills essential for scientifically literate citizens and future …

Can Ai Hold Office Hours?, Lisa Larrimore Ouellette, Amy R. Motomura, Jason Reinecke, Jonathan S. Masur

Public Law and Legal Theory Working Papers

Rapid improvements in AI tools offer transformative opportunities in legal education, including the possibility of students using AI tools to answer questions that students might otherwise ask during office hours. But a critical challenge is the accuracy of these tools’ responses. Both general-purpose and law-specific AI models have been shown to “hallucinate” incorrect responses to a range of legal questions. Here, we evaluate the current capabilities of AI models when given the more constrained task of answering questions about a specific legal text. We provided three AI tools—OpenAI’s GPT-4o, Anthropic’s Claude 3.5 Sonnet, and Google’s NotebookLM—with the text of Masur …

Structural Logics Of Presidential Immunity, Aziz Z. Huq

Public Law and Legal Theory Working Papers

In Trump v. United States, the Supreme Court wrought two new presidential immunities from criminal prosecution. Supplemented by a pair of penumbral evidentiary rules, these inhibit criminal indictment or conviction of the president, and indeed many subordinate officials, across many imaginable fact-patterns. The Court justified this result on consequentialist, not originalist or precedential, grounds. But its analysis of immunity’s effects was radically incomplete. It focused narrowly on the person of the president, eschewing any attempt to situate or relate that individual’s incentives and behavior to the wider institutional contexts of the executive branch at large or the partisan-political environment of …

Constitutional Drafting Processes And Constitutional Success, Adam Chilton, Murat C. Mungan, Mila Versteeg

Public Law and Legal Theory Working Papers

Several recent constitution-making processes have been celebrated for being participatory, inclusive, and representative. However, many of these processes also failed. We theorize that aspects of these kinds of constitutional drafting processes could reduce the probability of constitutional success. To show why, we construct a “Constitution Drafting game” (CD game) in which representatives from different interest groups must draft a constitution. We consider the case where the probability of constitutional success is single peaked, but the value from successful adoption is increasing in the degree of issue protection chosen. The drafting process then leads to protection choices that are above those …

Atherogenic Lipoproteins Associate With Loss Of Glycemic Control In Youth-Onset Type 2 Diabetes: Results From The Today Study, Kimberly L Drews, Fida Bacha, Steven Willi, Santica Marcovina, Siripoom Mckay, Ruth S Weinstock, Today Study Group

Faculty, Staff and Students Publications

Background: Type 2 diabetes (T2D) in adolescents is associated with an unfavorable lipid profile, but lipoprotein particle subspecies and branched-chain amino acid (BCAA) data are scarce.

Objective: To evaluate lipoprotein particle distributions, lipoprotein insulin resistance index (LP-IR), and BCAA levels longitudinally and their relationships with sex, race/ethnicity, treatment, and loss of glycemic control in adolescents with youth-onset T2D.

Methods: Participants from the TODAY study (n = 348) had samples analyzed yearly for glycated hemoglobin and nuclear magnetic resonance lipoprotein and BCAA assessments.

Results: At baseline, participants with T2D were 13.7 years old with T2D, obesity, and from racial and ethnic …

The Influence Of Ultra-Widefield Fluorescein Angiography On The Diagnosis And Management Of Diabetic Retinopathy, Joelle A Hallak, Rawan Allozi, Aziz A Khanifar, Thanos D Papakostas, Christina Y Weng, Ronald C Gentile, J Peter Campbell, Jessica G Lee, Gennady Landa, Felix Y Chau, William F Mieler, Meenakashi Gupta, Amani A Fawzi, Judy E Kim, Jennifer I Lim, Robison Vernon Paul Chan

Faculty, Staff and Students Publications

Purpose: To study the influence of ultra-widefield fluorescein angiography (FA) on the diagnosis and management of diabetic retinopathy (DR).

Methods: Ten experts in DR completed an online survey in which they were asked to diagnose and manage DR cases using different imaging modalities. Experts independently reviewed 20 cases of DR and provided a diagnosis and management plan for each case, first based on ultra-widefield color-free and red-free images alone and again with the corresponding ultra-widefield FA images. Experts were polled on their diagnostic confidence, use of FA in clinical practice, and opinions on the value of ultra-widefield FA. Based on …

Clinician Attitudes Toward Palliative Care To Enhance The Quality Of Life For Patients With Sickle Cell Disease, Elizabeth Kvale

Faculty, Staff and Student Publications

Objectives: Palliative care (PC) is rare for patients with sickle cell disease (SCD). This study evaluated clinician attitudes toward PC for SCD.

Methods: A cross-sectional survey was conducted between October 2022 and February 2023. Clinicians were recruited from institutions across the United States.

Results: Eighty-six participants completed the survey. Most were physicians (90%), female (72%), had >10 years of experience (63%), and lacked prior PC training (57%). Most participants agreed (83%) that patients with SCD would benefit from PC, disagreed (99%) that PC is only for dying patients, and expressed interest (91%) in learning about PC interventions. Clinicians with prior …

Correlates Of Gacha Gaming, Minh Quang Nguyen

Graduate Theses/Dissertations

The purpose of this study was to explore the relationship between impulsive measures, income spending on gaming, and delayed discounting in a Gatha player sample. Two model approaches were employed: (1) a mediation model approach predicting delayed discounting with age and education level as mediators and (2) a multiple regression model predicting delayed discounting. Although the proposed models were exploratory, it was the contention of the author that these analyses would result in a better understanding of delayed discounting in Gacha gaming. Both age and education level were not correlated with the dependent variable (spending ratio), therefore the mediation model …

Characterizing A Rad23 Dependent Ultraviolet Radiation Resistance In Tetrahymena Thermophila, Emma June Liimatta

Graduate Theses/Dissertations

In 2020, 10 million deaths were attributed to cancer, with multidrug resistance being responsible for over 90% of deaths in cancer patients receiving treatment. This study utilized the model organism Tetrahymena thermophila to study how cells become resistant to Ultraviolet Radiation (UV) radiation, a process similar to multidrug resistance, specifically focusing on the nucleotide excision repair and ubiquitin shuttle protein Rad23. The National Cancer Institute documented 30-60% of cancers tested had a mutation in RAD23. Knockdown of RAD23 in Tetrahymena thermophila demonstrated a UV resistance phenotype with decreased nucleotide excision repair and differential expression of proteins active within caspase-independent …

Development Of Cyan And Blue Thermostable Fluorescent Proteins: Characterization And Structural Analysis, Acacia J. Jurkowski

Graduate Theses/Dissertations

Fluorescent proteins are commonly used as cell markers in living organisms. Modifications by mutation can be used to improve the qualities of these proteins including fluorescence, thermostability, pH stability, and chemical stability. The goal of this project is to use mutagenesis to improve the fluorescence of thermostable cyan and blue proteins derived from the thermal green protein (TGP). The first cyan protein developed by the DeVore lab (CTP 0.0) shifted the fluorescence to cyan but decreased the quantum yield (Φ_F) to 0.056. Further mutations were incorporated to increase the quantum yield through incorporating hydrogen bonding interactions to the …

A Study Of Collegiate Equine Team Funding, Expenditures, And Recruitment Strategies, Sydni Marie Nilles

Graduate Theses/Dissertations

Collegiate equine teams (including horse judging, equestrian, ranch horse teams) have been recognized for their contributions to students' personal and professional development for post- graduation success. Teams have been used to provide opportunities, a sense of belonging and allow for experiences students may not have elsewhere. However, there is a notable gap in knowledge as to where funding comes from and how much teams may be able to budget for expenditures. Recruitment tactical knowledge provides other teams with knowledge of potential areas they may be lacking or unaware of. I used an online survey to understand current ranges of support …

Braiding Culture Through Ceramics & Mixed Media Sculpture, Joy M. Okokon

Graduate Theses/Dissertations

Stories are embedded in each strand of Nigerian hair, serving as a bridge across generations and embodying the legacy of cultural expression. Hair-making, a skill passed down through generations in my family, began as a personal practice and has evolved into a powerful means of exploring and showcasing the cultural significance of hair braiding through creative works. The sculptures included in this thesis, Braiding Culture Through Ceramics & Mixed Media Sculpture, feature hair sculpture, afro combs, stools, adire batik made from materials such as clay, wood, glaze and cotton fabric. These materials are carefully selected for their cultural relevance and …

Learned Helplessness: An Online Replication And Validation, Arshpreet (Sunny) Kandola

Graduate Theses/Dissertations

The current study entails the partial replication of a classic learned helplessness two-phase triadic design experiment within an online learning context and aimed to validate a new attributional style self-report measure designed to identify individual differences in tendencies to develop learned helplessness consistent with the original reformulation of the hypothesis. Further, recent innovations in neuroscientific technology have allowed for a deeper examination of the mechanisms at play, finding support for a major re-interpretation of the theory of learned helplessness - suggesting that helplessness is more so the default passive response, while the active ingredient that is detected or expected (i.e., …

Dystopian Politics In The Hunger Games Series, Tristan Hogan

Graduate Theses/Dissertations

Suzanne Collins’s The Hunger Games series takes readers to a fictional country known as Panem that hosts an annual nationwide celebration in which adolescents compete in a battle to the death. In this analysis, I approach this book series with a Marxist lens to argue that the capitalistic system in Panem satirizes American culture in the early 21st century. Every novel in the series, through this theory, can be read as what scholars identify as a “critical dystopia,” a defamiliarized version of our culture, upheld through institutions and social participation in a way that satirizes ours. I argue that the …

Cgrp Modulation Of Intracellular Calcium Levels In Trigeminal Ganglion Neurons And Glia, Nicole M. Nalley

Graduate Theses/Dissertations

Elevated levels of calcitonin gene-related peptide (CGRP) are implicated in migraine and TMD pathology, but its effects on the excitability state of Aδ and C-fiber neurons and glia have not been investigated. The goal of this study was to determine changes mediated by CGRP on intracellular calcium levels in trigeminal ganglion neurons and glia in response to depolarizing stimulation. Intracellular calcium levels were determined in Aδ and C-fiber neurons of primary trigeminal ganglion cultures obtained from neonatal Sprague Dawley rats using Fura-2 and fluorescent microscopy. Cells were left untreated or preincubated for 2 hours with CGRP, then incubated with the …

The Influence Of Flower-Microbe Interactions On Bumble Bee Behavior And Gut Microbiome Composition, Success Chiamaka Ekemezie

Graduate Theses/Dissertations

This thesis examines how microbial interactions in floral nectar and environmental variation influence bumble bee (Bombus spp.) foraging behavior and gut microbiome composition. Pollen germination experiments and behavioral assays in the lab tested whether Metschnikowia reukaufii (yeast) and Acinetobacter nectaris (bacteria) induce pollen germination and bursting in nectar and affect bee behavior subsequently. Both microbes reduced intact pollen, but bees did not alter flower preference. Furthermore, the study also assessed how floral and bee community composition shaped gut microbiome composition across six Missouri prairies. Using amplicon-sequenced fungal ITS and bacterial 16S rRNA genes, I found that fungal microbiome composition varied …

A Novel Deterrence Strategy: Denial Through Space And Cyberspace, Nathan A. Heard

Graduate Theses/Dissertations

The United States faces numerous security threats now and in the coming decades. Authoritarian and revisionist powers such as China and Russia, along with regional proxies, are destabilizing the international order. The ability of the United States to adequately address these present and future threats is constrained by conventional and nuclear forces in need of recapitalization, a rising national deficit, disagreements over the direction of U.S. foreign policy, and a defense industrial enterprise that has its roots in the Cold War. In a multi-peer threat environment, this situation erodes U.S. credibility and is an invitation for aggression. Coercion, coordinated multi-theater …

Advancing Natural Resource Management Through Artificial Intelligence, Jonathan Fisk

Graduate Theses/Dissertations

Natural aquatic systems are characterized by complex ecological processes and interactions occurring across multiple scales, and quantifying them is essential for proper management. However, managers often face decreasing budgets, increasing responsibilities, and limited staffing, resulting in challenges related to data prioritization, digitization, and management. While modern analytical technologies offer powerful tools, their effectiveness relies heavily on timely and accurate data input from diverse sources, including written, audio, and visual formats. Traditional data management practices are time-consuming, particularly due to the need for manual data verification. To address these challenges, innovative technologies leveraging artificial intelligence (AI)—including deep learning, machine learning, and …