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2025

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Congolese Refugee Narratives Of Belonging, Grief, And Cultural Continuity In Appalachia, Kayla Davis Jan 2025

Congolese Refugee Narratives Of Belonging, Grief, And Cultural Continuity In Appalachia, Kayla Davis

Theses and Dissertations

This research examines the communicative challenges that Congolese refugees face after resettlement, particularly as they strive to reconstruct a sense of belonging in the United States that reflects their experiences in either their home country or secondary countries where they endured protracted displacement in refugee camps. Narrative qualitative research methods were used to conduct interviews with five Congolese refugees in Appalachia. Through qualitative thematic and lexical analysis derived from the interviews, the study reveals patterns of linguistic isolation, community continuity, and emotional displacement. A key finding is that participants often conceptualize community not as a geographic entity, but as an …


Exploring Refugee Students’ Experiences In Midwest Higher Education Environments: Culturally Responsive Practices For Educators, Rohana De Silva Jan 2025

Exploring Refugee Students’ Experiences In Midwest Higher Education Environments: Culturally Responsive Practices For Educators, Rohana De Silva

Theses and Dissertations

This qualitative study examined the teaching and learning strategies used by highereducation faculty to support refugee students at a Midwestern university. Recognizing that refugee students bring diverse cultural, linguistic, and experiential backgrounds to academic environments, this research examined how instructional practices can either promote or hinder their educational success. Traditional teaching methods often fall short in addressing the complex needs of this student population. Using Yosso’s Community Cultural Wealth Framework, Bourdieu’s Theory of Cultural Capital, and Resilience Theory, this study analyzed the narratives of refugee students to uncover how their lived experiences influenced their educational journeys. Findings revealed that refugee …


Adhd Research And Practice: An Evaluation Of Psychologists’ Utilizations Of Adhd Assessments In Practice, Desiree Giesen Jan 2025

Adhd Research And Practice: An Evaluation Of Psychologists’ Utilizations Of Adhd Assessments In Practice, Desiree Giesen

Theses and Dissertations

The incidence of first-time Attention-Deficit/Hyperactivity Disorder (ADHD) diagnoses among adults has been on the rise. There is limited research on effective practices for evaluating adult ADHD, with previous studies showing conflicting results regarding the effectiveness of various assessment measures. The current study investigates the assessment tools chosen by psychologists and their perceived importance in evaluating ADHD. A cross-sectional design was used with 200 participants who were primarily licensed psychologists. The unstructured clinical interview with the client was the most used assessment tool and was rated as having the highest importance, whereas continuous performance tasks were rated as having the lowest …


Rethinking Pilot Retention In The United States: An Analysis Of Key Factors, Michael James Hickey Jan 2025

Rethinking Pilot Retention In The United States: An Analysis Of Key Factors, Michael James Hickey

Theses and Dissertations

This thesis examined pilot retention challenges in U.S. regional and low-cost carriers (LCCs), focusing on nonfinancial incentives such as quality of life, career stability, and work-life balance, which may have a greater influence on retention than traditional financial incentives. This quantitative, survey-based approach assesses how pilots rank the factors that influence their retention. Using a sample of U.S.-based pilots, the study examines six key areas adapted from a European pilot retention framework. Statistical analyses, including the Friedman test, the Mann-Whitney U test, and the Kruskal-Wallis test, identified correlations between demographic variables and retention priorities. The inherent financial constraints of regional …


Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock Jan 2025

Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock

Theses and Dissertations

The introduction of Name, Image, and Likeness (NIL) regulations in collegiate athletics has created new financial and branding opportunities for student-athletes. Simultaneously, there has been an evolving legal landscape surrounding cannabinoids both at the state and National Collegiate Athletic Association (NCAA) levels. This dissertation in practice explores this emerging intersection by examining student-athlete perceptions of NIL opportunities with cannabinoid brands and highlighting the perceived advantages and disadvantages of such deals. This dissertation in practice consists of three artifacts. Artifact I provides essential background information on NIL, cannabinoids, and the House v. NCAA settlement. Recognizing the legal, institutional, and cultural shifts …


An Intersectional Exploration And Analogue Investigation Of Transgender And Gender Diverse Bi+ Women’S Preferences For Sexual Violence Vulnerability Reduction Interventions, Sara K. Kuhn Jan 2025

An Intersectional Exploration And Analogue Investigation Of Transgender And Gender Diverse Bi+ Women’S Preferences For Sexual Violence Vulnerability Reduction Interventions, Sara K. Kuhn

Theses and Dissertations

Transgender and gender diverse (TGD) bisexual+ (bi+, e.g., pansexual, polysexual) women disproportionately experience sexual violence victimization and their acceptability of applicable interventions is under-researched. Online self-report data was collected from 240 ethnoracially diverse bi+ adult American women, who identified as TGD (n = 69) or cisgender (cis; n = 171), and who read standardized descriptions of interventions. TGD bi+ women found intervention descriptions inclusive of their sexual and gender identities—and those including in-person active resistance strategy instruction (bystander/self-defense)—more acceptable. Intervention descriptions with alcohol use and/or sexual activity reduction components were largely found to be less acceptable. Intervention elements of importance …


A Phenomenological Study Of The Motivations, Persistence And Challenges Of African Immigrant Adult Learners In Community Colleges In Minnesota, Saah Jackson Delu Kpakar Jan 2025

A Phenomenological Study Of The Motivations, Persistence And Challenges Of African Immigrant Adult Learners In Community Colleges In Minnesota, Saah Jackson Delu Kpakar

Theses and Dissertations

African Immigrant Adult Learners (AIAL) are considered an exclusive demographic group who left Africa and obtained permanent residency in the United States. They experience a wide range of challenges in their quest for postsecondary education, which impact their access, persistence, and academic success. The purpose of this qualitative study based on a phenomenological approach was to explore the factors that motivate African Immigrant Adult Learners and enable them to persist and remain resilient in their pursuit of higher education at community colleges in Minnesota. The theories that guided this research are the Self-Determination Theory (SDT) and Schlossberg’s Transition Theory (STT). …


Examining A Year One Sor Implementation: A Mixed-Method Study Of Teacher Experiences And Student Literacy Scores, Christine Litzinger Jan 2025

Examining A Year One Sor Implementation: A Mixed-Method Study Of Teacher Experiences And Student Literacy Scores, Christine Litzinger

Theses and Dissertations

With increasing national and legislative mandates prioritizing SoR practices, many schools are shifting their literacy practices to align classroom instruction, interventions, and screening to follow reading research, which can require a shift in pedagogy for individual educators and schools. This exploratory sequential mixed-methods study explored a year one implementation of the Science of Reading (SoR) in a mid-size midwestern school district during their first year of across-district literacy reform. Qualitative case study interviews were conducted of K-3 Classroom teachers (4) and literacy coaches (4). Emergent themes from the findings included value in high fidelity professional development, challenges related to resource …


Impact Of Resin Grinding On Per- And Polyfluoroalkyl Substance Adsorption In Rapid Small-Scale Column Tests, Tihitna Gezahegn Mulugeta Jan 2025

Impact Of Resin Grinding On Per- And Polyfluoroalkyl Substance Adsorption In Rapid Small-Scale Column Tests, Tihitna Gezahegn Mulugeta

Theses and Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with significant health risks. Among the different technologies for PFAS removal, adsorption is preferable due to low-cost, operational simplicity, and use of regenerable adsorbents. While pilot-scale fixed-bed columns are ideal for evaluating adsorption media, they are time- and resource-intensive. Rapid Small-Scale Column Tests (RSSCTs) offer a practical alternative, yet most studies have focused on granular activated carbon, with limited insight into ion exchange (IX) resins. Due to limited literature on the effect resin preparation on the performance of RSSCTs and their prediction accuracies are unexplored. This study investigates the effect of …


Advancing Human-Computer Interaction Systems Through Explainable And Secure Ai Integration, Ifiok Udoidiok Jan 2025

Advancing Human-Computer Interaction Systems Through Explainable And Secure Ai Integration, Ifiok Udoidiok

Theses and Dissertations

As artificial intelligence (AI) systems increasingly shape how humans interact with digital environments, the need for transparency, security, and robustness in intelligent decision making has become critical. This thesis explores how explainable and secure AI techniques can be integrated into modern human-computer interaction (HCI) systems to enhance trust, resilience, and alignment with human operators.

We present three related studies, each addressing a distinct challenge in the design of human-centered AI. First, we apply XAI methods, specifically Local Interpretable Model-Agnostic Explanations (LIME), to deep learning (DL) based CAPTCHA solvers. By interpreting model attention patterns, we uncover exploitable weaknesses in text CAPTCHA …


Zaasijiwan: An Indigenized Health Communication Framework For American Indian And Alaska Native Communities, Jennifer Wolf Jan 2025

Zaasijiwan: An Indigenized Health Communication Framework For American Indian And Alaska Native Communities, Jennifer Wolf

Theses and Dissertations

The Zaasijiwan Framework represents an Indigenized health communication model developed to enhance the cultural relevance, trust, and effectiveness of public health messaging for American Indian and Alaska Native (AI/AN) communities. This qualitative study integrated Indigenous and Western public health knowledge to inform the development of the framework. A comprehensive literature review and two rounds of key informant interviews with health communication professionals informed the design of the framework. Findings emphasized the importance of community co-creation and strengths-based narratives, along with other framework elements, in overcoming medical mistrust and improving health outcomes. The final framework offers public health professionals, Tribal, and …


Public Perceptions Of Fracking And Anti-Fracking Activism: A Theory Of Planned Behavior Approach And Its Implications For Environmental Policy, Okhumode Hector Yakubu Jan 2025

Public Perceptions Of Fracking And Anti-Fracking Activism: A Theory Of Planned Behavior Approach And Its Implications For Environmental Policy, Okhumode Hector Yakubu

Theses and Dissertations

Hydraulic fracturing, or fracking, has become one of the most contentious energy technologies of the 21st century, drawing support for its economic and energy security benefits and opposition due to its perceived environmental and health risks. This study applies the Theory of Planned Behavior (TPB) to examine the psychological, social, and informational factors that shape public perceptions of fracking and motivate anti-fracking activism. Using a nationally representative sample of U.S. adults (N = 522), this research investigates how attitudes, subjective norms, perceived behavioral control, and domain-specific knowledge predict support or opposition to fracking, as well as intentions to engage in …


Shedding Light To The Rights To Light In England And Wales: The Need For Reform, Goodtime Okara Jan 2025

Shedding Light To The Rights To Light In England And Wales: The Need For Reform, Goodtime Okara

School of Law, Humanities and Social Sciences

The right to light is unarguably a right that could hinder the development of the servient land. Owing to the possibility of granting a mandatory injunction when breached, this right could lead to extra costs and delays in the efficient development of the servient land by real property developers, even when the dominant tenement does not wish to enjoy the right. Hence, this paper critically reflects on rights to light in England and Wales to determine the impact of this right on the servient land. It explores the direction of travel across the Courts – by briefly examining rights to …


Exploring Islamophobia Through Intersectionality., Suparna Bagchi Jan 2025

Exploring Islamophobia Through Intersectionality., Suparna Bagchi

School of Law, Humanities and Social Sciences

No abstract provided.


Cold Water Swimming And Pregnancy: A Scoping Review And Consensus Recommendations, J. Shawe, M. Felton, J. C. Harper, C. Mark Harper, R. Stidson, M. Tipton, S. Blowers, K. Fraser, S. Hingley, E. Mcgrath, G. Bainbridge, Massey Heather Jan 2025

Cold Water Swimming And Pregnancy: A Scoping Review And Consensus Recommendations, J. Shawe, M. Felton, J. C. Harper, C. Mark Harper, R. Stidson, M. Tipton, S. Blowers, K. Fraser, S. Hingley, E. Mcgrath, G. Bainbridge, Massey Heather

School of Nursing and Midwifery

Introduction: Cold water swimming has increased in popularity and women wish to swim throughout pregnancy. There is a lack of evidenced-based guidance to make decisions about the safety of immersion in cold water during pregnancy. Methods: Closed social media groups were asked for specific questions in relation to cold water swimming and pregnancy. This highlighted concerns including water temperature, risks to the mother and fetus, and water quality. To find evidence-based answers, a series of meetings brought together clinicians and researchers with expertise in cold water physiology, exercise physiology, fertility, obstetrics, neonatology, midwifery, water epidemiology, public health and representatives from …


Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale Jan 2025

Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale

Peninsula Medical School

Introduction: There is evidence of an association between tolerance of ambiguity and psychological wellbeing in doctors, but this relationship is not well understood. We explored this relationship, and the individual or workplace factors moderating it, in a population of newly qualified doctors. Methods: We examined the experiences of newly qualified doctors in the UK as they started a novel interim role (Time 1) and later moved into foundation year 1 roles (Times 2 and 3) during the COVID-19 pandemic. Doctors completed the Tolerance of Ambiguity of Medical Students and Doctors scale (TAMSAD Range: 0–100), the Perceived Stress Scale (PSS: 0–40), …


Discussing Poverty Within Primary Care Consultations: Implications For Mental Health Support, F. Thomas, K. Wyatt, K. Berzins, I. Lee, J. Horrell, A. Mcloughlin Jan 2025

Discussing Poverty Within Primary Care Consultations: Implications For Mental Health Support, F. Thomas, K. Wyatt, K. Berzins, I. Lee, J. Horrell, A. Mcloughlin

Peninsula Medical School

No abstract provided.


A Mapping Review Of Studies Exploring The Barriers And Facilitators To A Dementia Diagnosis Through An Intersectionality Lens, Ben Hicks, Katherine Wheatley, Emma Porter, Nicolas Farina, Sube Banerjee Jan 2025

A Mapping Review Of Studies Exploring The Barriers And Facilitators To A Dementia Diagnosis Through An Intersectionality Lens, Ben Hicks, Katherine Wheatley, Emma Porter, Nicolas Farina, Sube Banerjee

Peninsula Medical School

BackgroundPromoting a ‘timely’ diagnosis is a global policy directive.AimsThis review adopts an intersectional approach, visually mapping the existing literature to highlight gaps in the evidence base on barriers and facilitators to dementia diagnosis.MethodA systematic approach was undertaken, following the PRISMA guidelines, updating previous reviews. The literature search was conducted on PubMed, PsycINFO, CINAHL Complete and Scopus. In line with mapping review methodology, we report the current state of the literature by describing the number of studies that outline barriers and facilitators to seeking help for a dementia diagnosis, split by social categorisation.ResultsOn the 7 June 2024, a total of 45 …


Machine Learning-Guided Discovery Of Metal-Ligand Catalysts For Affordable Green Hydrogen Produced Via Proton Exchange Membrane Electrolyzers, Achouak Benarbia Jan 2025

Machine Learning-Guided Discovery Of Metal-Ligand Catalysts For Affordable Green Hydrogen Produced Via Proton Exchange Membrane Electrolyzers, Achouak Benarbia

Theses and Dissertations

The rising demand for clean and sustainable energy sources has underscored the critical role of hydrogen in the global energy transition. However, the widespread adoption of green hydrogen remains constrained by the high cost and scarcity of platinum-based electrocatalysts used in Proton Exchange Membrane (PEM) electrolyzers. This dependence inflates production costs and poses long-term risks related to supply security and scalability. While numerous studies have explored alternative materials, the discovery of efficient and stable non-platinum catalysts remains a major bottleneck due to the vastness of chemical space and the resource-intensive nature of experimental screening. To address this challenge, this study …


Next-Gen Device For Uniform Cellular Migration Assay Execution, Nicholas M. Bittner Jan 2025

Next-Gen Device For Uniform Cellular Migration Assay Execution, Nicholas M. Bittner

Theses and Dissertations

Cellular migration assays, particularly scratch assays, are pivotal in biomedical research for cell motility, wound healing, and metastasis. However, conventional scratch assays suffer from variability due to operator dependence, non-uniform scratch geometry, and a modified microenvironment that impacts reproducibility. This thesis presents the development and validation of a low-cost, 3D-printed device designed to standardize cellular migration assays. The device utilizes a spring mechanism and a biocompatible elastomer to create a uniform cellular exclusion zone without harming the surrounding cells. Through iterative prototyping and testing with MCF10A cell lines, the device demonstrated a significantly lower average standard deviation of length compared …


Characterization Of Methylated Histone Modifications During Simian Virus 40 Early Transcription, Jacob Otto Haugen Jan 2025

Characterization Of Methylated Histone Modifications During Simian Virus 40 Early Transcription, Jacob Otto Haugen

Theses and Dissertations

Modifications of histone proteins play an important role in transcription. These modifications regulate how chromatin is compacted by the histone proteins and either made available for transcription or prevents transcription machinery from proceeding. The modifications can be added or removed by histone acetyltransferases and histone methyltransferases for the former, and histone deacetylates and demethylases for the latter. To explore the dynamicity of these modifications we used the simple but effective Simian Virus 40 (SV40) model. SV40 continues to be an important tool in understanding eukaryotic transcription. It experiences similar processes as cellular chromatin, utilizing host proteins to propagate its own …


Ethical Implications Of Chatgpt And Other Large Language Models In Academia, Ahmad Almufarreh, Ashfaq Ahmad, Muhammad Arshad, Choo Wou Onn, Robinson Elechi Jan 2025

Ethical Implications Of Chatgpt And Other Large Language Models In Academia, Ahmad Almufarreh, Ashfaq Ahmad, Muhammad Arshad, Choo Wou Onn, Robinson Elechi

Research Outputs: 2025-Present

The rapid advancement of technology in the digital age has significantly transformed human communication and knowledge exchange. At the forefront of this transformation are Large Language Models (LLMs), powerful neural networks trained on vast text corpora to perform a wide range of Natural Language Processing (NLP) tasks. While LLMs offer promising benefits such as enhanced productivity and human-like text generation, their integration into academic settings raises pressing ethical concerns. This study investigates the ethical dimensions surrounding the use of LLMs in academia, driven by their increasing prevalence and the need for responsible adoption. A mixed-methods approach was employed, combining surveys, …


A Hybrid Transformer Architecture For Multiclass Mental Illness Prediction Using Social Media Text, Adnan Karamat, Muhammad Imran, Muhammad Usman Yaseen, Rasool Bukhsh, Sheraz Aslam, Nouman Ashraf Jan 2025

A Hybrid Transformer Architecture For Multiclass Mental Illness Prediction Using Social Media Text, Adnan Karamat, Muhammad Imran, Muhammad Usman Yaseen, Rasool Bukhsh, Sheraz Aslam, Nouman Ashraf

Research Outputs: 2025-Present

Mental illness prediction through text involves employing natural language processing (NLP) techniques and deep learning algorithms to analyze textual data for the identification of mental disorders. Therefore, machine learning and deep learning algorithms have been utilized in the existing literature for the detection of mental illness. However, current systems exhibit suboptimal performance primarily due to their reliance on traditional embedding techniques and generic language models to generate text embeddings. To address this limitation, there is a requirement for domain-specific pretrained language models that comprehensively understand the context found in posts of person with a psychiatric disability patients. Posts from individuals …


An Empirical Evaluation Of Communication Technologies And Quality Of Delivery Measurement In Networked Microgrids, Yasin Emir Kutlu, Ruairí De Fréin Jan 2025

An Empirical Evaluation Of Communication Technologies And Quality Of Delivery Measurement In Networked Microgrids, Yasin Emir Kutlu, Ruairí De Fréin

Research Outputs: 2025-Present

Networked microgrids (NMG) are gaining popularity as an example of smart grids (SG), where power networks are integrated with communication technologies. Communication technologies enable NMGs to be monitored and controlled via communication networks. However, ensuring that communication networks in NMGs satisfy quality of delivery (QoD) metrics such as the round trip time (RTT) of NMG control data is necessary. This paper addresses the communication network types and communication technologies used in NMGs. We present various NMG deployments to demonstrate real-life applicability in different contexts. We develop a real-time NMG testbed using real hardware, such as Cisco 4331 Integrated Services Routers …


Investigating Nutrition And Supportive Care Needs In Esophageal And Gastric Cancer Survivors: A Cross-Sectional Survey, Fatemeh Sadeghi, Juliette Hussey, Suzanne L. Doyle Jan 2025

Investigating Nutrition And Supportive Care Needs In Esophageal And Gastric Cancer Survivors: A Cross-Sectional Survey, Fatemeh Sadeghi, Juliette Hussey, Suzanne L. Doyle

Research Outputs: 2025-Present

Background/Objectives: Advances in cancer diagnosis and treatment improved survivorship rates, but survivors’ long-term quality of life remains a critical concern. Survivors of esophageal and gastric cancer often undergo extensive curative surgery, which can have lasting impacts on nutritional status. This study aimed to assess the nutritional status, dietary challenges, and supportive care needs of this population of cancer survivors. Methods: In this cross-sectional study, adults diagnosed with esophageal or gastric cancer were invited to complete an anonymous survey to assess their nutritional status, quality of life, and psychological well-being. Results: A total of 114 responses were analyzed. Although over 70% …


“One Size Doesn’T Fit All”: Nutrition Care Needs In Esophageal And Gastric Cancer Survivors—A Qualitative Study, Fatemeh Sadeghi, Juliette Hussey, Suzanne L. Doyle Jan 2025

“One Size Doesn’T Fit All”: Nutrition Care Needs In Esophageal And Gastric Cancer Survivors—A Qualitative Study, Fatemeh Sadeghi, Juliette Hussey, Suzanne L. Doyle

Research Outputs: 2025-Present

Background/Objectives: Nutritional complications are highly prevalent in esophageal and gastric cancer survivors and can negatively impact their quality of life. Gaining insight into survivors’ experiences with nutrition care can inform the development of tailored nutrition care programs for this population. The present study investigated esophageal and gastric cancer survivors’ nutritional challenges and complications. It also explored survivors’ and their carers’ perceived unmet nutrition care needs. Methods: Esophageal and gastric cancer survivors and their caregivers were invited to participate in a semi-structured interview. Participants were asked about their nutritional challenges and experiences with existing dietetic services in meeting their nutrition care …


Integration Of The Portionsize Ed App Into Snap-Ed For Improving Diet Quality Among Adolescents In Hawaii: A Randomized Pilot Study, Emerald S. Proctor, Kiari H.L. Aveiro, Ian Pagano, Lynne R. Wilkens, Leihua Park, Leilani Spencer, Jeannie Butel, Corby K. Martin, John W. Apolzan, Rachel Novotny, John Kearney, Chloe P. Lozano Jan 2025

Integration Of The Portionsize Ed App Into Snap-Ed For Improving Diet Quality Among Adolescents In Hawaii: A Randomized Pilot Study, Emerald S. Proctor, Kiari H.L. Aveiro, Ian Pagano, Lynne R. Wilkens, Leihua Park, Leilani Spencer, Jeannie Butel, Corby K. Martin, John W. Apolzan, Rachel Novotny, John Kearney, Chloe P. Lozano

Research Outputs: 2025-Present

Background/Objectives: Coupling mobile health (mHealth) technology with community-based nutrition programs may enhance diet quality in adolescents. This pilot study evaluated the feasibility, acceptability, and preliminary efficacy of integrating PortionSize Ed (PSEd), an image-assisted dietary assessment and education app, into the six-week Hawaii Food and Lifeskills for Youth (HI-FLY) curriculum delivered via Supplemental Nutrition Assistance Program Education (SNAP-Ed). Methods: Adolescents (grades 6–8) from two classrooms were cluster-randomized into HI-FLY or HI-FLY + PSEd. Both groups received HI-FLY and completed Youth Questionnaires (YQ) and food records (written or app-based) at Weeks 0 and 7. Feasibility and acceptability were assessed via enrollment, attrition, …


Anti-Cd137 Agonist Antibody-Independent And Clinically Feasible Preparation Of Tumor-Infiltrating Lymphocytes From Soft Tissue Sarcoma And Osteosarcoma, Yining Jin, Zhiliang Jia, Xueqing Xia, Nancy B Gordon, Joseph A Ludwig, Neeta Somaiah, Shulin Li Jan 2025

Anti-Cd137 Agonist Antibody-Independent And Clinically Feasible Preparation Of Tumor-Infiltrating Lymphocytes From Soft Tissue Sarcoma And Osteosarcoma, Yining Jin, Zhiliang Jia, Xueqing Xia, Nancy B Gordon, Joseph A Ludwig, Neeta Somaiah, Shulin Li

Faculty, Staff and Student Publications

Background: Tumor infiltrating lymphocytes (TILs) therapy has been proved for treatment of metastatic melanoma and is under investigation for other types of solid tumors. However, these successes are threatened by discontinued supply of GMP-grade anti-CD137 agonist, a key TIL preparation reagent. Therefore, exploring a GMP-adherent method for expanding endogenous TILs without anti-CD137 agonist is urgent. Toward this end, we aimed to establish an anti-CD137-independent and clinically feasible TIL expansion protocol to prepare TILs from under investigated sarcoma tumors.

Methods: We collected resected tumors from patients and cut tissues into fragments. We used IL-2 and T-cell activator CD3/CD28 without anti-CD137 agonist …


Fatty Pancreas On Eus: Risk Factors, Correlation With Ct/Mri, And Implications For Pancreatic Cancer Screening, Ramez M Ibrahim, Shantanu Solanki, Wei Qiao, Hyunsoo Hwang, Ben S Singh, Irina M Cazacu, Adrian Saftoiu, Matthew H G Katz, Michael P Kim, Florencia Mcallister, Manoop S Bhutani Jan 2025

Fatty Pancreas On Eus: Risk Factors, Correlation With Ct/Mri, And Implications For Pancreatic Cancer Screening, Ramez M Ibrahim, Shantanu Solanki, Wei Qiao, Hyunsoo Hwang, Ben S Singh, Irina M Cazacu, Adrian Saftoiu, Matthew H G Katz, Michael P Kim, Florencia Mcallister, Manoop S Bhutani

Faculty, Staff and Student Publications

Background and objectives: Fatty pancreas (FP), traditionally perceived as a benign finding, has been undergoing scrutiny lately due to growing evidence linking it to various disease states, including increased risk for pancreatic cancer (PC).

Methods: A retrospective study of patients who underwent EUS at a single institution from August 2007 to October 2023, conducted by one endosonographer with more than 25 years of experience. Focusing on individuals identified with FP during EUS, we compared these findings with corresponding findings on computed tomography/magnetic resonance imaging (CT/MRI) conducted within 3 months or 1 year prior to or following EUS.

Results: Ninety-one patients …


Upregulation Of Delta Opioid Receptor By Meningeal Interleukin-10 Prevents Relapsing Pain, Kufreobong E Inyang, Jaewon Sim, Kimberly B Clark, Matan Geron, Karli Monahan, Christine Evans, Patrick O'Connell, Sophie Laumet, Bo Peng, Jiacheng Ma, Cobi J Heijnen, Robert Dantzer, Grégory Scherrer, Annemieke Kavelaars, Matthew Bernard, Yasser A Aldhamen, Joseph K Folger, Alexis Bavencoffe, Geoffroy Laumet Jan 2025

Upregulation Of Delta Opioid Receptor By Meningeal Interleukin-10 Prevents Relapsing Pain, Kufreobong E Inyang, Jaewon Sim, Kimberly B Clark, Matan Geron, Karli Monahan, Christine Evans, Patrick O'Connell, Sophie Laumet, Bo Peng, Jiacheng Ma, Cobi J Heijnen, Robert Dantzer, Grégory Scherrer, Annemieke Kavelaars, Matthew Bernard, Yasser A Aldhamen, Joseph K Folger, Alexis Bavencoffe, Geoffroy Laumet

Faculty, Staff and Student Publications

Chronic pain often includes periods of transient amelioration and even remission that alternate with severe relapsing pain. While most research on chronic pain has focused on pain development and maintenance, there is a critical unmet need to better understand the mechanisms that underlie pain remission and relapse. We found that interleukin (IL)-10, a pain resolving cytokine, is produced by resident macrophages in the spinal meninges during remission from pain and signaled to IL-10 receptor-expressing sensory neurons. Using unbiased RNA-sequencing, we identified that IL-10 upregulated expression and antinociceptive activity of δ-opioid receptor (δOR) in the dorsal root ganglion. Genetic or pharmacological …