Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 36841 - 36869 of 36869

Full-Text Articles in Entire DC Network

Whose Decolonization? Prospects For Decolonizing African Art Music, Kofi Agawu Jan 2025

Whose Decolonization? Prospects For Decolonizing African Art Music, Kofi Agawu

Publications and Research

Although they date back to the 1960s—the decade of African independence—decolonization discourses have gained a new visibility in today’s academies and social media. Targets of decolonization include universities (and numerous practices within), archives, museums, political and economic systems, and individuals from previously colonized nations. Questions remain, however, about what, why, and how to decolonize. This article explores the prospects for decolonizing African art music, a repertoire formed from the twin forces of missionization and colonization. Eschewing a big-picture approach, the author focuses on samples of African choralism, African pianism, African opera, and African symphonism to show that the dividing lines …


Hybrid Cooperative Spectrum Structured (Hcss) Approach For Adaptive Routing In Cognitive Radio Ad Hoc Networks, Sadeem Dheyaa Shamsi, Ameer Sameer Hamood Mohammed Ali, Wameed Deyah Shamsi Jan 2025

Hybrid Cooperative Spectrum Structured (Hcss) Approach For Adaptive Routing In Cognitive Radio Ad Hoc Networks, Sadeem Dheyaa Shamsi, Ameer Sameer Hamood Mohammed Ali, Wameed Deyah Shamsi

Mesopotamian Journal of CyberSecurity

Cognitive radio networks provide an important function in the efficient use of the radio spectrum. Therefore, dedicated cognitive radio ad hoc networks (CRAHNs) are expected to improve communication performance in a multihop network that requires a dedicated routing protocol that considers the dynamic mobility of secondary user nodes on the basis of the random availability of primary node channels. To enhance routing in the CRAHNs environment, in this paper, a novel Hybrid Cooperative Spectrum Structured (HCSS) approach that combines cooperative spectrum sensing and spectrum-aware routing protocols can be effective in appropriate decision making for routing packets in such a network. …


Exploring The Impact Of Blockchain Revolution On The Healthcare Ecosystem: A Critical Review, Maad M. Mijwil, Mohammad Aljanabi, Mostafa Abotaleb, Ban Salman Shukur, Ban Salman Shukur, Indu Bala, Kamal Kant Hiran, Ruchi Doshi, Klodian Dhoska Jan 2025

Exploring The Impact Of Blockchain Revolution On The Healthcare Ecosystem: A Critical Review, Maad M. Mijwil, Mohammad Aljanabi, Mostafa Abotaleb, Ban Salman Shukur, Ban Salman Shukur, Indu Bala, Kamal Kant Hiran, Ruchi Doshi, Klodian Dhoska

Mesopotamian Journal of CyberSecurity

Blockchain technology is a type of distributed ledger that provides secure and efficient storage, management, and transmission of data over a decentralized network. With its ability to ensure transparency and immutability, blockchain is increasingly adopted across various sectors ranging from finance, healthcare, and logistics to education. In healthcare, blockchain technology is attracting attention because of its potential to fundamentally transform health ecosystems. The healthcare sector has significantly benefited from blockchain technology by enhancing data security and interoperability and reducing medical errors. In this context, a set of studies highlighted the importance of blockchain in the field of healthcare, enhancing trust …


Learning Techniques-Based Malware Detection: A Comprehensive Review, Sarah Fouad Ali, Musaab Riyadh Abdulrazzaq, Methaq Talib Gaata Jan 2025

Learning Techniques-Based Malware Detection: A Comprehensive Review, Sarah Fouad Ali, Musaab Riyadh Abdulrazzaq, Methaq Talib Gaata

Mesopotamian Journal of CyberSecurity

The rapid proliferation of Internet of Things (IoT) devices has significantly increased the threat landscape, with malwares arising as a critical concern. Advanced learning methods such as machine learning (ML), deep learning (DL), and federated learning (FL) are essential for handling complex IoT data. ML provides tools for pattern identification and detecting anomalies. DL boosts malware detection by automatically extracting features and identifying patterns. FL enables collaborative model training across decentralized devices, ensuring data privacy, which is crucial for diverse IoT systems. This comprehensive review specifically synthesizes ML, DL and FL for malware detection in the IoT environment, highlighting key …


Enhancing Traffic Data Security In Smart Cities Using Optimized Quantum-Based Digital Signatures And Privacy-Preserving Techniques, Tuqa Ghani Tregi, Mishall Al-Zubaidie Jan 2025

Enhancing Traffic Data Security In Smart Cities Using Optimized Quantum-Based Digital Signatures And Privacy-Preserving Techniques, Tuqa Ghani Tregi, Mishall Al-Zubaidie

Mesopotamian Journal of CyberSecurity

Securing big data in power plants is an important and fundamental step in the infrastructure of smart cities. In addition, it becomes a barrier if it is not controlled from the beginning. Security must be a combination of fast and robust properties. This research presents a traffic security system (TSS) in a smart city (SC). It is a novel paradigm meant to improve data security and integrity by means of a multilayered method. Advanced fault analysis, dual-stage pseudonymizing, quantum key distribution via the BB84 protocol, and Falcon signatures (FS) are combined in the proposed system. TSS enhances data security by …


The Representation Of Feminine Beauty In Generative Artificial Intelligence Models, Haley R. Stacy Jan 2025

The Representation Of Feminine Beauty In Generative Artificial Intelligence Models, Haley R. Stacy

Murray State Theses and Dissertations

As Artificial Intelligence (AI) technology advances, its influence on media and societal perceptions becomes increasingly significant. This dissertation explores how popular generative visual AI models represent women and the implications for racial and body type inclusivity. This study examines women’s perceptions of AI-generated representations. Two primary research questions are being explored: (1) How do AI-generated algorithms represent women in visual outputs when prompted with broad beauty-related keywords? (2) How do women perceive their representation in these AI-generated visual outputs? Through a detailed analysis of AI-generated imagery, the research uncovers implicit and explicit biases within these systems. The research also gathered …


The Effects Of Parenting Styles On Childhood Memories And Resilience Building, Nathaniel Paredes Jan 2025

The Effects Of Parenting Styles On Childhood Memories And Resilience Building, Nathaniel Paredes

Murray State Theses and Dissertations

One of the most significant agents of shaping children early in life is their parental figures. There has been extant research into parenting styles and outcomes later in life. The current study sought to understand how parenting styles can influence the formation of positive and adverse childhood experiences (PCEs and ACEs), which in turn lead to the development of resilience later in life. It was expected that participants who reported higher levels of authoritative parenting would be significantly correlated with higher levels of positive childhood experiences, and lower levels of adverse childhood experiences. Secondly, authoritarian and permissive parenting would be …


Managing Campus Dissent: An Assessment Of University Responses To Pro-Palestinian Protests, Kathryn S. Walker Jan 2025

Managing Campus Dissent: An Assessment Of University Responses To Pro-Palestinian Protests, Kathryn S. Walker

Murray State Theses and Dissertations

University leaders face challenges navigating student dissent and effectively upholding free speech while encouraging students to view the world from a new perspective. Higher education institutions employ a variety of strategies to handle campus crises and mitigate negative perceptions that may arise. This qualitative research study provides insight into the crisis communication strategies employed by university administrators at ten institutions with the highest number of pro-Palestinian protest days from October 7, 2023, to May 29, 2024, through the analysis of university statements and student newspaper responses. Campus leaders found themselves in a challenging position, unable to satisfy all constituencies. Each …


Examining Kentucky Agriculture Teachers’ Use Of Student Credentialing In Agricultural Education Programming, Kaycee J. Palmeri, Kevin T. Wells Jan 2025

Examining Kentucky Agriculture Teachers’ Use Of Student Credentialing In Agricultural Education Programming, Kaycee J. Palmeri, Kevin T. Wells

Murray State Theses and Dissertations

The purpose of this qualitative study was to explore Kentucky agriculture teachers’ perceptions regarding current industry credential offerings, how they operationalize the curricula, knowledge, and skills necessary to prepare for industry credential offerings, and the perceived benefits for students who earn such credentials. The current study was undergirded by human capital theory. Using random sampling across the 12 Kentucky FFA service regions, the researcher collected data from nine current Kentucky agriculture teachers via semi-structured interviews. Further, the researcher used a Qualtrics-based instrument to collect participant demographics data. The analysis of the interview data revealed eight distinct emerging themes. The researcher …


Too Much Information: The Role Everyday Information Plays In The Understanding Of Mental Health, Jeremy M. Morgan Jan 2025

Too Much Information: The Role Everyday Information Plays In The Understanding Of Mental Health, Jeremy M. Morgan

Murray State Theses and Dissertations

Information overload has become increasingly problematic within the world of mental health, as people are able to go online and access overwhelming amounts of mental health-related information within seconds. The aim of the current study was to examine the interaction between excess mental health information and individuals’ understanding of mental health, specifically Autism Spectrum Disorder (ASD), as well as self-diagnosis. Data from 128 participants was examined. The data collected related to participants’ online search and use patterns of ASD information, their understanding of ASD symptoms, as well as their experiences with those symptoms. Results indicated a significant positive correlation between …


The Role Of Adverse Childhood Experiences On Aggression And Substance Use In Young Adulthood, Sadie Goralski Jan 2025

The Role Of Adverse Childhood Experiences On Aggression And Substance Use In Young Adulthood, Sadie Goralski

Murray State Theses and Dissertations

Adverse childhood experiences (ACEs) are widespread within the United States. More than half of the population has experienced at least one adverse event during their youth. Such experiences range from parental divorce to sexual assault. Past research has shown that adverse experiences during the formative years play a major role in the development of multiple physical and mental health issues. The current study aimed to explore the interplay among ACEs and two of these covariates: aggression and substance use. Moreover, the proposed study further investigated the development of substance use in emotionally dysregulated individuals with past adverse experiences. In doing …


Elementary School Mathematics Teacher Perspectives Of Blended Learning, Elizabeth H. Forrester Jan 2025

Elementary School Mathematics Teacher Perspectives Of Blended Learning, Elizabeth H. Forrester

Murray State Theses and Dissertations

This qualitative case study explored the experiences and perceptions of teachers who utilize technology for instructional purposes, blended learning in elementary school instruction, and the impact of professional development (PD) on blended learning instruction. Guided by the Technological, Pedagogical, and Content Knowledge theory (TPACK), research aims to understand teachers' motivation and use of blended learning during instruction and the impact PD has had on teachers’ implementation of blended learning. Data was collected through semi-structured interviews of seven elementary school teachers in grades two through five in the state of Kentucky. Findings revealed that teachers experienced technology integration instruction during their …


Dirty Water, Breanna Booker, Michael S. Sinha Jan 2025

Dirty Water, Breanna Booker, Michael S. Sinha

All Faculty Scholarship

Plastics are taking over. Every day, humans are exposed to plastic pollutants in a variety of ways. From the water we use to water crops in the field, to the water in our taps, to the liquids we drink from plastic containers, it can be found virtually anywhere you look. Not only is it everywhere in the environment, but it is also within us. It builds up in our bodies. Plastics have become a major public health concern; researchers estimate that the total healthcare cost related to plastic chemicals may be as much as $250 billion.[1]

Water has always …


Baseline Clinical Characterization Of Participants In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al. Jan 2025

Baseline Clinical Characterization Of Participants In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al.

2020-Current year OA Pubs

BACKGROUND: This paper focuses on the baseline clinical characterization of the participants in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program. The AMP SCZ program is designed to investigate a wide array of clinical variables and biomarkers in a total of 2040 clinical high-risk (CHR) participants and 652 community control (CC) participants.

METHODS: The dataset analyzed includes 1642 individuals at clinical high risk for psychosis and 519 CCs. Key measures include the Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the Structured Interview for Psychosis-Risk Syndromes, which determined CHR criteria and the severity …


Sample Ascertainment And Recruitment Sources In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al. Jan 2025

Sample Ascertainment And Recruitment Sources In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al.

2020-Current year OA Pubs

BACKGROUND: This paper presents the recruitment sources of clinical high-risk (CHR) and community controls (CC) from the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program, which aims to study various clinical variables and biomarkers in 2040 CHR and 652 CC participants.

METHODS: A total of 1640 CHR and 514 CC had recruitment source data. The Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the SIPS was utilized to assess CHR criteria and severity of attenuated psychotic symptoms (APSs), and the Global Functioning: Social Scale was used for social functioning. Participants were recruited through various …


Enhancing Engagement In Hiv Care Among Adolescents And Young Adults: A Focus On Phone-Based Navigation And Relationship Building To Address Barriers In Hiv Care, Harriet Fridah Adhiambo, Dorothy Imbuka Mangale, Elvin Geng, Et Al. Jan 2025

Enhancing Engagement In Hiv Care Among Adolescents And Young Adults: A Focus On Phone-Based Navigation And Relationship Building To Address Barriers In Hiv Care, Harriet Fridah Adhiambo, Dorothy Imbuka Mangale, Elvin Geng, Et Al.

2020-Current year OA Pubs

Structural, psychological, and clinical barriers to HIV care engagement among adolescents and young adults living with HIV (AYAH) persist globally despite gains in HIV epidemic control. Phone-based peer navigation may provide critical peer support, increase delivery flexibility, and require fewer resources. Prior studies show that phone-based navigation and automated text messaging interventions improve HIV care engagement, adherence, and retention among AYAH. However, little is known about AYAH experiences utilizing electronic phone-based peer navigation and automated text messaging (E-NAV). We assessed the experiences of AYAH receiving phone-based peer navigation to address barriers to HIV care engagement and viral suppression. We purposefully …


Evolution And Recent Radiation Therapy Advancement In Uganda: A Precedent On How To Increase Access To Quality Radiotherapy Services In Low- And Middle-Income Countries, Awusi Kavuma, Solomon Kibudde, Daniel Kanyike, Joseph Kigula-Mugambe, Tianyu Zhao, Hiram Gay, Baozhou Sun, Jackson Orem Jan 2025

Evolution And Recent Radiation Therapy Advancement In Uganda: A Precedent On How To Increase Access To Quality Radiotherapy Services In Low- And Middle-Income Countries, Awusi Kavuma, Solomon Kibudde, Daniel Kanyike, Joseph Kigula-Mugambe, Tianyu Zhao, Hiram Gay, Baozhou Sun, Jackson Orem

2020-Current year OA Pubs

The evolution of radiation therapy in Uganda has been a journey marked by significant milestones and persistent challenges. Since the inception of radiotherapy services in 1988-1989, there has been a concerted effort to enhance cancer treatment services. The early years were characterized by foundational developments, such as the installation of the first teletherapy units, low-dose-rate brachytherapy units, and conventional simulators, and the recognition of radiation oncologists and medical physicist professionals laid the groundwork for radiotherapy treatment modalities. With more support from the International Atomic Energy Agency, the acquisition of dosimetry equipment, treatment planning systems, and additional professional training signaled a …


Tracking The Evolving Role Of Artificial Intelligence In Implementation Science: Protocol For A Living Scoping Review Of Applications, Evaluation Approaches And Outcomes [Version 2; Peer Review: 2 Approved], Guillaume Fontaine, Byron J Powell, Et Al. Jan 2025

Tracking The Evolving Role Of Artificial Intelligence In Implementation Science: Protocol For A Living Scoping Review Of Applications, Evaluation Approaches And Outcomes [Version 2; Peer Review: 2 Approved], Guillaume Fontaine, Byron J Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: Artificial intelligence (AI) offers significant opportunities to improve the field of implementation science by supporting key activities such as evidence synthesis, contextual analysis, and decision-making to promote the adoption and sustainability of evidence-based practices. This living scoping review aims to: (1) map applications of AI in implementation research and practice; (2) identify evaluation approaches, reported outcomes, and potential risks; and (3) synthesize reported research gaps and opportunities for advancing the use of AI in implementation science.

METHODS: This scoping review will follow the Joanna Briggs Institute (JBI) methodology and the Cochrane guidance for living systematic reviews. A living scoping …


Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black Jan 2025

Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

We summarize research reports from 2024 relevant to Tourette syndrome, which the authors consider the most important or interesting. This working draft aims to submit this content for publication around the beginning of 2025 in the yearly Tourette Syndrome Research Highlights series on F1000Research. The authors welcome article suggestions and thoughtful feedback from readers, who can add a comment by clicking on the rectangular comment box icon to the left of the LOG IN link at the top of this page. For private comments, you can reach us by email ( [email protected] or [email protected]).


Schistosomiasis Interventions In Africa: Assessment And Systematic Review, Christopher Yaw Dumevi, George Boateng Kyei, Patience B Tetteh-Quarcoo, James-Paul Kretchy, Irene Ayi, Patrick F Ayeh-Kumi Jan 2025

Schistosomiasis Interventions In Africa: Assessment And Systematic Review, Christopher Yaw Dumevi, George Boateng Kyei, Patience B Tetteh-Quarcoo, James-Paul Kretchy, Irene Ayi, Patrick F Ayeh-Kumi

2020-Current year OA Pubs

No abstract provided.


Qualitative And Quantitative Analysis Of A Novel Dental Health Education Program To Improve Dental Care Utilization By Bhutanese-, Burmese-, And Swahili-Speaking Refugees In A Midwestern United States City, Chandra Swanson, Katherine Gordon, Kelly Kreisler, Elizabeth Montgomery Collins Jan 2025

Qualitative And Quantitative Analysis Of A Novel Dental Health Education Program To Improve Dental Care Utilization By Bhutanese-, Burmese-, And Swahili-Speaking Refugees In A Midwestern United States City, Chandra Swanson, Katherine Gordon, Kelly Kreisler, Elizabeth Montgomery Collins

2020-Current year OA Pubs

No abstract provided.


Estimating Preclinical Amyloid Positivity: A Case Study Transporting Adni To Aric, Emma K Stapp, Elizabeth Rose Mayeda, Elizabeth A Stuart, Rebecca F Gottesman, Scott C Zimmerman, Dean F Wong, Thomas H Mosley, Michael E Griswold, M Maria Glymour, Melinda C Power, Alzheimer's Disease Neuroimaging Initiative Jan 2025

Estimating Preclinical Amyloid Positivity: A Case Study Transporting Adni To Aric, Emma K Stapp, Elizabeth Rose Mayeda, Elizabeth A Stuart, Rebecca F Gottesman, Scott C Zimmerman, Dean F Wong, Thomas H Mosley, Michael E Griswold, M Maria Glymour, Melinda C Power, Alzheimer's Disease Neuroimaging Initiative

2020-Current year OA Pubs

INTRODUCTION: Alzheimer's disease and related dementias researchers have benefited from deeply phenotyped clinical samples; however, there is a critical need for estimates that generalize to diverse, representative populations. Use of a statistical approach from causal inference, "transport," may allow generalization of findings from clinical samples to other target populations. Here we explore the feasibility and validity of extending results from a clinical sample, the Alzheimer's Disease Neuroimaging Initiative (ADNI), to a community-based target sample, the Atherosclerosis Risk in Communities Study Positron Emission Tomography Amyloid Imaging Study (ARIC-PET) using transport estimation and a standard approach, direct standardization, which itself can be …


Proceedings Of The 12th Annual Deep Brain Stimulation Think Tank: Cutting Edge Technology Meets Novel Applications, Alfonso Enrique Martinez-Nunez, Nico U F Dosenbach, Evan M Gordon, Et Al. Jan 2025

Proceedings Of The 12th Annual Deep Brain Stimulation Think Tank: Cutting Edge Technology Meets Novel Applications, Alfonso Enrique Martinez-Nunez, Nico U F Dosenbach, Evan M Gordon, Et Al.

2020-Current year OA Pubs

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson's disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for …


Early Alzheimer's Disease Patient Care Pathway And Health System Readiness: A Framework For Integrated Care, Ilya M Nasrallah, Erik S Musiek, Et Al. Jan 2025

Early Alzheimer's Disease Patient Care Pathway And Health System Readiness: A Framework For Integrated Care, Ilya M Nasrallah, Erik S Musiek, Et Al.

2020-Current year OA Pubs

UNLABELLED: Alzheimer's disease (AD) is often underdiagnosed, especially at early stages when symptoms are mild, and patients may benefit from new and recently approved anti-amyloid therapies. An updated patient care pathway may facilitate timely diagnosis and intervention. We conducted a scan of published information and convened an expert panel of health care professionals to gain insights on early AD care pathways. We developed an Early AD Patient Care Pathway as an implementation guide that includes new diagnostic and treatment modalities and addresses needs and opportunities. The Early AD Patient Care Pathway focuses on patient identification, assessment, diagnosis, treatment, and management …


Case Report: Molecular Characterization Of Adult Atypical Teratoid Rhabdoid Tumor And Review Of The Literature, Miguel A Hernandez-Rovira, Michelle Connor, Robert C Osorio, Emilie Russler-Germain, Robert Schmidt, Gabrielle W Johnson, Julie Silverstein, Sonika Dahiya, Nyssa Fox Farrell, Mia C Weiss, Gregory J Zipfel, Jiayi Huang, Dimitrios Mathios Jan 2025

Case Report: Molecular Characterization Of Adult Atypical Teratoid Rhabdoid Tumor And Review Of The Literature, Miguel A Hernandez-Rovira, Michelle Connor, Robert C Osorio, Emilie Russler-Germain, Robert Schmidt, Gabrielle W Johnson, Julie Silverstein, Sonika Dahiya, Nyssa Fox Farrell, Mia C Weiss, Gregory J Zipfel, Jiayi Huang, Dimitrios Mathios

2020-Current year OA Pubs

BACKGROUND AND IMPORTANCE: Atypical teratoid rhabdoid tumors (ATRTs) are typically aggressive pediatric tumors with a median survival of 11 months. Due to the paucity of cases in adults, the clinical behavior of these pathologies is not well understood. Here we present the case of a 41-year-old female patient with postoperative hyperprogression of a sellar ATRT and provide a detailed description of the molecular composition of this tumor, the protocol used to treat this patient, and the ultimate outcome of this patient.

CLINICAL PRESENTATION: The patient is a 41-year-old woman who presented with headaches and double vision. MRI revealed a sellar/suprasellar …


Use Of Telehealth For Measurement Of Anthropometrics In Toddlers And Their Parents, Sarah S Farabi, Cindy Schwarz, Bria Lee-Robinson, Lauren G Fiechtner, Victor Davila-Roman, Rachel G Tabak, Debra Haire-Joshu Jan 2025

Use Of Telehealth For Measurement Of Anthropometrics In Toddlers And Their Parents, Sarah S Farabi, Cindy Schwarz, Bria Lee-Robinson, Lauren G Fiechtner, Victor Davila-Roman, Rachel G Tabak, Debra Haire-Joshu

2020-Current year OA Pubs

INTRODUCTION: The use of telehealth (e.g., live video calling) to collect anthropometric data in toddlers and their parents to increase participation in lifestyle interventions holds promise. But, there is limited evidence to support reliability of telehealth for the collection of these measures. This study aimed to determine the reliability of use of telehealth with parents to collect anthropometric and blood pressure measures on themselves and anthropometric measures on their toddler and determine the acceptability of instruction.

METHODS: This cross-sectional study was conducted as part of the developmental phase of a larger study. Research staff instructed parents via video call to …


Identification Of Candidate Cardiomyopathy Modifier Genes Through Genome Sequencing And Rna Profiling, Malene E Lindholm, Gerald W Dorn, Et Al. Jan 2025

Identification Of Candidate Cardiomyopathy Modifier Genes Through Genome Sequencing And Rna Profiling, Malene E Lindholm, Gerald W Dorn, Et Al.

2020-Current year OA Pubs

BACKGROUND: Phenotypic heterogeneity is apparent among individuals with putative monogenic disease, such as familial hypertrophic cardiomyopathy. Genome sequencing (GS) allows interrogation of the full spectrum of inborn genetic variation in an individual and RNA profiling provides a snapshot of the cardiac-specific pathogenic effects on gene expression.

OBJECTIVES: Identify candidate genetic modifiers of hypertrophic cardiomyopathy phenotype.

METHODS: We performed GS of 48 individuals with variants in

RESULTS: GS identified the

CONCLUSION: Evaluation of the whole genome, even in the case of alleged monogenic disease, leads to important new insights. The identified variants, regions, and genes are candidates to modify disease presentation …


Th9 Cells Provide Protective Tb Immunity, Mei Xia, Azra Blazevic, Huan Ning, Christopher S Eickhoff, Chad E Storer, Richard D Head, Jianguo Liu, Jessica Jarvela, David Stoeckel, Erin Rakey, Jan Tennant, Daniel L Miller, Kathleen R Holloway, Richard F Silver, Daniel F Hoft Jan 2025

Th9 Cells Provide Protective Tb Immunity, Mei Xia, Azra Blazevic, Huan Ning, Christopher S Eickhoff, Chad E Storer, Richard D Head, Jianguo Liu, Jessica Jarvela, David Stoeckel, Erin Rakey, Jan Tennant, Daniel L Miller, Kathleen R Holloway, Richard F Silver, Daniel F Hoft

2020-Current year OA Pubs

INTRODUCTION: CD4+ Th9 cells have been associated with inflammatory and allergic diseases. IL-9/Th9 can function as both positive and negative immune regulators, but their protective effects against

METHODS: To study TB-specific Th9 protective effects, we generated Th9 cells from ESAT6-specific TCR transgenic mice and healthy human donors.

RESULTS: Both murine and human Th9 cells significantly inhibited intracellular mycobacterial growth. In both

DISCUSSION: Th9 cells can provide important protection against Mtb infection, and should be targeted with future TB vaccine strategies. Furthermore, Th9 cells appear to utilize a novel protective mechanism independent from Th1-mediated protective responses.


The Perfect Storm: Unraveling The Interplay Of Genetic Predisposition And Viral Triggers In Type 1 Diabetes Pathogenesis, Daniel A Veronese-Paniagua, Jeffrey R Millman Jan 2025

The Perfect Storm: Unraveling The Interplay Of Genetic Predisposition And Viral Triggers In Type 1 Diabetes Pathogenesis, Daniel A Veronese-Paniagua, Jeffrey R Millman

2020-Current year OA Pubs

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the T cell-mediated destruction of insulin-secreting pancreatic β cells, leaving patients reliant on exogenous insulin to establish normoglycemia. Despite advancements in glucose management, the precise pathological mechanisms linking genetic predisposition and environmental triggers to the loss of immune tolerance remain incompletely understood, hindering the development of preventative therapies. This comprehensive review synthesizes clinical, experimental, and epidemiological data to detail the intricate pathogenesis of T1D, focusing on the convergence of autoimmunity, high-risk genetics, and enteroviral infection. We discuss how T1D is fundamentally a disease caused by failures in central and …