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Articles 71011 - 71040 of 71370
Full-Text Articles in Entire DC Network
Whole Exome Sequencing As A Screening Tool In Dogs: A Pilot Study, Fréderique Boeykens, Evelien Bogaerts, Liesbeth Vossaert, Luc Peelman, Filip Van Nieuwerburgh, Jimmy H Saunders, Bart J G Broeckx
Whole Exome Sequencing As A Screening Tool In Dogs: A Pilot Study, Fréderique Boeykens, Evelien Bogaerts, Liesbeth Vossaert, Luc Peelman, Filip Van Nieuwerburgh, Jimmy H Saunders, Bart J G Broeckx
Faculty, Staff and Students Publications
Background: Whole-exome sequencing (WES) is used to selectively sequence all exons of protein-coding genes. WES is considered as a cost-effective and direct approach for identifying phenotype-associated variants in protein-coding regions and is as such situated between the traditional Sanger sequencing and whole genome sequencing (WGS). While WES is already widely used as a clinical tool in human and medical genetics, its use in veterinary medicine is currently restricted to research purposes. In this article, we aimed to provide baseline performance characteristics of a WES design to assess its suitability with future applications in veterinary clinical genetics in mind.
Methods: To …
Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici
Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici
Faculty, Staff and Students Publications
Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections continue to occur in vaccinated individuals, contributing to further viral mutation and spread. These limitations may be attributable to the poor induction of mucosal immunity by parenteral vaccination. Mucosal adjuvants, such as T-vant, can enhance vaccine-induced immune responses through the generation of antigen-specific antibodies and T cells in the respiratory tract. In this study, we evaluated the protective efficacy of adjuvanted SARS-CoV-2 receptor binding domain (RBD) subunit vaccines administered by homologous and heterologous routes. Immunized mice were challenged with …
Real-World Experiences With Vmat2 Inhibitors In Pediatric Hyperkinetic Movement Disorders, Sujal Manohar, Jennifer Jacobe, Rebecca Berger, Joseph Jankovic, Mariam Hull
Real-World Experiences With Vmat2 Inhibitors In Pediatric Hyperkinetic Movement Disorders, Sujal Manohar, Jennifer Jacobe, Rebecca Berger, Joseph Jankovic, Mariam Hull
Faculty, Staff and Students Publications
Background: Vesicular monoamine transporter 2 (VMAT2) inhibitors are often prescribed for the treatment of hyperkinetic movement disorders such as tics, stereotypy, tardive dyskinesia and chorea. These dopamine depleters have been FDA approved in adults for the treatment of chorea in Huntington's disease and tardive dyskinesia. Use of VMAT2 inhibitors in pediatric hyperkinetic movement disorders, however, is limited due to lack of pediatric FDA approval. We review the real-world prescribing practices and patient experiences with VMAT2 inhibitors in children.
Methods: We performed a retrospective chart review of patients treated with VMAT2 inhibitors at a pediatric movement disorders clinic from 2011 to …
Promotion Of Hiv Clearance By Sensitization Of Hiv Reservoirs To Cell Death, Min Li, Baichao Sun, Jing Dong, Jian-Rong Li, Laurie J Minze, Min Chen, Chao Cheng, Jin Wang
Promotion Of Hiv Clearance By Sensitization Of Hiv Reservoirs To Cell Death, Min Li, Baichao Sun, Jing Dong, Jian-Rong Li, Laurie J Minze, Min Chen, Chao Cheng, Jin Wang
Faculty, Staff and Students Publications
Introduction: HIV integrates its proviral DNA into the host genome to establish persistent infection. To promote HIV clearance, we have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through inhibition of autophagy and anti-apoptotic molecules during viral reactivation. SECH approach can clear HIV-infected cells in approximately 50% humanized mice. However, the mechanisms for the resistance of reservoirs to depletion in mice with failure in HIV clearance are unclear.
Methods: We have performed single cell transcriptome analyses of HIV-infected T cells that escaped the treatments, in order to identify cellular pathways that could be targeted to …
Tobacco Exposure Linked To Warthin’S Tumor Being The Most Common Benign Parotid Neoplasm In Veterans: A Retrospective Cohort Study, Louis Abarca, Linda K Green, Ray Y Wang, Vlad C Sandulache, David J Hernandez
Tobacco Exposure Linked To Warthin’S Tumor Being The Most Common Benign Parotid Neoplasm In Veterans: A Retrospective Cohort Study, Louis Abarca, Linda K Green, Ray Y Wang, Vlad C Sandulache, David J Hernandez
Faculty, Staff and Students Publications
Objective: Parotid gland neoplasms account for a large proportion of benign salivary gland tumors, with pleomorphic adenomas (PA) being the most common in the civilian population, followed by Warthin's tumor (WT). However, the distinct risk profiles of Veterans significantly influence the incidence and prevalence of salivary gland neoplasms. We investigated the diagnostic and management algorithms for benign parotid gland neoplasms in Veterans.
< >Methods: Retrospective cohort study. Descriptive statistics were calculated using Microsoft Excel. Categorical variables were compared using chi square tests, and were reported with 95% confidence intervals, with statistical significance set at P < .05.
Results: The study included 158 patients …
Relationships Of Personality Traits With The Taxonomic Composition Of The Gut Microbiome Among Psychiatric Inpatients, William Orme, Sandra L Grimm, Divya S N Vella, J Christopher Fowler, B Christopher Frueh, Benjamin L Weinstein, Joseph Petrosino, Cristian Coarfa, Alok Madan
Relationships Of Personality Traits With The Taxonomic Composition Of The Gut Microbiome Among Psychiatric Inpatients, William Orme, Sandra L Grimm, Divya S N Vella, J Christopher Fowler, B Christopher Frueh, Benjamin L Weinstein, Joseph Petrosino, Cristian Coarfa, Alok Madan
Faculty, Staff and Students Publications
Objective: Through the brain-gut-microbiome axis, myriad psychological functions that affect behavior share a dynamic, bidirectional relationship with the intestinal microbiome. Little is known about the relationship between personality-a stable construct that influences social- and health-related behaviors-and the bacterial ecosystem. The authors of this exploratory study examined the relationship between general and maladaptive personality traits and the composition of the gut microbiome.
Methods: In total, 105 psychiatric inpatients provided clinical data and fecal samples. Personality traits were measured with the five-factor model of personality, the Structured Clinical Interview for DSM-IV Axis II Personality Disorders, and the Personality Inventory for DSM-5; 16S …
Paternal Upd (15) With Disease-Causing Mutation And Small Supernumerary Ring Chromosome 15: A Case Report, David Lee Curtis, Nasim Bekheirnia, Lorraine Potocki, Ludmila Matyakhina, Mir Reza Bekheirnia
Paternal Upd (15) With Disease-Causing Mutation And Small Supernumerary Ring Chromosome 15: A Case Report, David Lee Curtis, Nasim Bekheirnia, Lorraine Potocki, Ludmila Matyakhina, Mir Reza Bekheirnia
Faculty, Staff and Students Publications
Uniparental disomy (UPD) constitutes an unconventional mode of inheritance that disrupts the typical biparental genetic contribution and may result in phenotypic abnormalities. This report centers on a patient diagnosed with Bartter syndrome Type 1, attributed to a homozygous pathogenic variant in SLC12A1 unmasked by mosaic paternal UPD of chromosome 15. We hypothesize that this pattern (or constellation) emerged from a trisomy rescue event, resulting in two distinct cell lines. Concurrently, the unmasking of a pathogenic paternal SLC12A1 variant by trisomy rescue resulted in the manifestation of Bartter syndrome Type 1. The maternally derived ring chromosome 15 and its impact on …
What Is The Robustness Of Randomized Controlled Trials Supporting Rhinosinusitis Guidelines?, Najm S Khan, Aatin K Dhanda, Masayoshi Takashima, Richard Liu, Yuki Yoshiyasu, Wenbo Wu, Whitney Jin, Edward D Mccoul, Murugappan Ramanathan, Omar G Ahmed
What Is The Robustness Of Randomized Controlled Trials Supporting Rhinosinusitis Guidelines?, Najm S Khan, Aatin K Dhanda, Masayoshi Takashima, Richard Liu, Yuki Yoshiyasu, Wenbo Wu, Whitney Jin, Edward D Mccoul, Murugappan Ramanathan, Omar G Ahmed
Faculty, Staff and Students Publications
Purpose: To determine the robustness of randomized controlled trials (RCTs) supporting the current rhinosinusitis guideline; International Consensus Statement on Allergy and Rhinology: rhinosinusitis (ICAR-RS).
Materials & methods: RCTs referenced by ICAR-RS with primary dichotomous outcomes were analyzed. The Fragility Index (FI) was calculated for trials with statistically significant findings. Trial characteristics, the FI, and FI minus number lost to follow-up (LTF) were assessed for associations.
Results: A total of 317 RCTs were identified, with 38 trials possessing a primary dichotomous outcome. Thirty-one percent evaluated surgical interventions and 24 % were industry-sponsored. The mean sample size was 116 with 9 patients, …
Developing An Annual Review Of The Literature, Weinstein R Amy, Szauter Karen, Duca Nicholas, Jacob Jackcy, Ismail Nadia, Pincavage Amber, Walsh Katherine, Alexandraki Irene
Developing An Annual Review Of The Literature, Weinstein R Amy, Szauter Karen, Duca Nicholas, Jacob Jackcy, Ismail Nadia, Pincavage Amber, Walsh Katherine, Alexandraki Irene
Faculty, Staff and Students Publications
Many national meetings and speaker series feature an "Annual Review of the Literature" (ARL) session in which an individual or team presents a sampling of articles, selected and prepared because they represent important current topics or new ideas in the discipline of interest. Despite this, there is little in the medical literature describing how to thoughtfully and systematically develop these sessions. We identify best practices that we have developed and used in the United States Clerkship Directors of Internal Medicine (CDIM) over many years. These include identification of a theme, team assembly, timeline development, search strategy and rubric development and …
Application Of A Digital Quality Measure For Cancer Diagnosis In Epic Cosmos, Andrew J Zimolzak, Sundas P Khan, Hardeep Singh, Jessica A Davila
Application Of A Digital Quality Measure For Cancer Diagnosis In Epic Cosmos, Andrew J Zimolzak, Sundas P Khan, Hardeep Singh, Jessica A Davila
Faculty, Staff and Students Publications
Objectives: Missed and delayed cancer diagnoses are common, harmful, and often preventable. We previously validated a digital quality measure (dQM) of emergency presentation (EP) of lung cancer in 2 US health systems. This study aimed to apply the dQM to a new national electronic health record (EHR) database and examine demographic associations.
Materials and methods: We applied the dQM (emergency encounter followed by new lung cancer diagnosis within 30 days) to Epic Cosmos, a deidentified database covering 184 million US patients. We examined dQM associations with sociodemographic factors.
Results: The overall EP rate was 19.6%. EP rate was higher in …
Cervical Cancer Prevention Behaviors In Young Black Women, Angela J Johnson, Monica J Johnson, Juinell B Williams, Emma Muscari, Laura Palmo, Michelle Ruiz, Brianna Bush, Lisa C Campbell
Cervical Cancer Prevention Behaviors In Young Black Women, Angela J Johnson, Monica J Johnson, Juinell B Williams, Emma Muscari, Laura Palmo, Michelle Ruiz, Brianna Bush, Lisa C Campbell
Faculty, Staff and Students Publications
Background: In the United States, Black women have the second highest incidence of cervical cancer (CC) due to high incidence of human papillomavirus (HPV), slow HPV clearance rates, and low receipt of preventive pap smears and vaccines.
Objective: A Black Feminist Thought framework was used to examine how the media portrayal of Black women, racial identity, and familial factors impact CC prevention behaviors among young Black women.
Design: Black women enrolled at a large southeastern university consented and participated in an online mixed-methods survey examining facilitators and barriers to CC prevention behaviors. Quantitative items were analyzed via descriptive statistics, and …
A Computational Approach To The Game Of Cycles, Jocelyn Garcia, Mike Janssen, Eliza Kautz
A Computational Approach To The Game Of Cycles, Jocelyn Garcia, Mike Janssen, Eliza Kautz
Faculty Work Comprehensive List
In Mathematics for Human Flourishing, Francis E. Su introduced The Game of Cycles, a game played on a finite simple planar graph. In game play, opponents alternate adding direction to the edges of the graph with the goal of creating a cycle or making the last legal move. Recent work has sought to determine winning strategies on certain classes of graphs. We introduce a tabular representation of a game state and provide a computer program that determines which player has a winning strategy on any legal game board. The program builds a directed graph of all possible game states, utilizing …
Puzzling Our Way Into Computational Thinking, David J. Mulder
Puzzling Our Way Into Computational Thinking, David J. Mulder
Faculty Work Comprehensive List
This unplugged activity is a brief, practical introduction to computational thinking that uses an accessible and decidedly low-tech approach: solving a jigsaw puzzle. The skills needed to collaboratively solve a jigsaw puzzle illustrate the key concepts of computational thinking in a straightforward way that makes the basics of decomposition, pattern recognition, abstraction, and algorithmic thinking come to life. The learning representation included here was taught as part of a professional development workshop for PK-12 teachers but could easily be adapted to use with learners from upper elementary grades through middle school, high school, or university.
Modeling Functional Connectivity With Learning And Memory In A Mouse Model Of Alzheimer’S Disease, Lindsay Fadel, Elizabeth Hipskind, Steen E Pedersen, Jonathan Romero, Caitlyn Ortiz, Eric Shin, Md Abul Hassan Samee, Robia G Pautler
Modeling Functional Connectivity With Learning And Memory In A Mouse Model Of Alzheimer’S Disease, Lindsay Fadel, Elizabeth Hipskind, Steen E Pedersen, Jonathan Romero, Caitlyn Ortiz, Eric Shin, Md Abul Hassan Samee, Robia G Pautler
Faculty, Staff and Students Publications
Introduction: Functional connectivity (FC) is a metric of how different brain regions interact with each other. Although there have been some studies correlating learning and memory with FC, there have not yet been, to date, studies that use machine learning (ML) to explain how FC changes can be used to explain behavior not only in healthy mice, but also in mouse models of Alzheimer's Disease (AD). Here, we investigated changes in FC and their relationship to learning and memory in a mouse model of AD across disease progression.
Methods: We assessed the APP/PS1 mouse model of AD and wild-type controls …
An Analytical Review Of Preprocessing Techniques In Bengali Natural Language Processing, Sovon Chakraborty, Protiva Das, Shakib Mahmud Dipto, Md Aktaruzzaman Pramanik, Jannatun Noor
An Analytical Review Of Preprocessing Techniques In Bengali Natural Language Processing, Sovon Chakraborty, Protiva Das, Shakib Mahmud Dipto, Md Aktaruzzaman Pramanik, Jannatun Noor
Computer Science Faculty Publications
Research in Bengali Natural Language Processing (BNLP) is rapidly expanding. Despite being one of the most widely spoken languages in the world, BNLP research remains insufficient, particularly in Bengali speech recognition. The languages rich morphology, agglutinative structure, and diverse dialects make text and speech processing especially challenging. However, these challenges can be addressed with effective preprocessing techniques. Various organizations in Bangladesh and West Bengal are integrating Natural Language Processing (NLP) into their services, but without a thorough understanding of preprocessing, these implementations remain incomplete. Applying proper preprocessing techniques to the Bengali language will serve as a foundation for developing robust …
Gout Flare Burden In The United States: A Multiyear Cross-Sectional Survey Study, Jasvinder A Singh, Amy Morlock, Robert Morlock
Gout Flare Burden In The United States: A Multiyear Cross-Sectional Survey Study, Jasvinder A Singh, Amy Morlock, Robert Morlock
Faculty, Staff and Students Publications
OBJECTIVE: The objective of this study was to assess the burden of gout flares and examine associated patient characteristics and outcomes in a sample of US adults.
METHODS: Data were collected via an online survey of US adults ≥18 years using a random stratified sampling framework. Participants with gout completed questions about treatments, serum urate (SU) levels, severity, satisfaction with control, and gout flares. All participants completed the Veterans RAND 12-Item Health Survey, the Generalized Anxiety Disorder 7-Item Scale, and the Patient Health Questionnaire 9-Item Scale. Data were summarized using descriptive statistics. Multivariable-adjusted logistic regression analyses examined factors predictive of …
The Frequency Of Informational Text Read-Alouds In Kindergarten And Its Association With Students’ Vocabulary And Knowledge Development, Sen Wang, Sonia Q. Cabell, Elizabeth Hadley, Jill M. Pentimonti, Arzu Gungor Leushuis
The Frequency Of Informational Text Read-Alouds In Kindergarten And Its Association With Students’ Vocabulary And Knowledge Development, Sen Wang, Sonia Q. Cabell, Elizabeth Hadley, Jill M. Pentimonti, Arzu Gungor Leushuis
Language, Literacy, Ed.D., Exceptional Education, and Physical Education Faculty Publications
While informational texts have been shown to enhance vocabulary and content knowledge, most prior research indicates that early childhood teachers seldom read such texts to their students. This study offers an updated perspective on the frequency of informational text use during read-aloud sessions by kindergarten teachers. These teachers work in a large urban U.S. district committed to building content knowledge through read-alouds during ELA instruction. Over the course of a semester, 38 teachers completed 174 reading logs, covering 310 titles, which yielded three key findings: the average proportion of informational text read-alouds was higher than reported in previous studies, there …
Tracing The Impact Of Covid-19 On Early Language And Literacy Development From Pre-K Through First Grade, Elizabeth Hadley, Siyu Liu, Eunsook Kim, Meaghan Mckenna, Katharine Hull
Tracing The Impact Of Covid-19 On Early Language And Literacy Development From Pre-K Through First Grade, Elizabeth Hadley, Siyu Liu, Eunsook Kim, Meaghan Mckenna, Katharine Hull
Language, Literacy, Ed.D., Exceptional Education, and Physical Education Faculty Publications
COVID-19 disrupted early educational experiences for a generation of children, but research on how missing school impacted academic development for young children is limited. This paper investigated the longitudinal impact of COVID-19 on the language and literacy development of children in a Florida school district, specifically following children who were in pre-K in March 2020 through the end of first grade. This COVID-19 cohort (n = 1,167) was compared with a pre-COVID-19 cohort (n = 1,211) using propensity score matching, multilevel regression models, and linear growth modeling. Results indicated that the negative impacts of COVID-19 on language and literacy emerged …
Impact Of Methicillin-Resistant Staphylococcus Aureus Surveillance And Decolonization In The Nicu: The Texas Children’S Hospital Experience, Nahid Hiermandi, Catherine Foster, Judith Campbell, Krystal Purnell, Elizabeth Tocco, Tjin Koy, Kenneth Nobleza, Duc Nguyen, Lucila Marquez
Impact Of Methicillin-Resistant Staphylococcus Aureus Surveillance And Decolonization In The Nicu: The Texas Children’S Hospital Experience, Nahid Hiermandi, Catherine Foster, Judith Campbell, Krystal Purnell, Elizabeth Tocco, Tjin Koy, Kenneth Nobleza, Duc Nguyen, Lucila Marquez
Faculty, Staff and Students Publications
OBJECTIVE: To determine the impact of screening and decolonization on methicillin-resistant
STUDY DESIGN: This is a single-center retrospective cohort study comparing patient characteristics among MRSA-colonized and MRSA-infected infants, rates of MRSA infection before and after screening with targeted decolonization, and MRSA infection among those receiving single or combined decolonization agents.
SETTING: Texas Children's Hospital Pavilion for Women is a 42-bed level three neonatal intensive care units (NICU) in Houston, TX.
PATIENTS: Neonates admitted to the NICU from 2012 to 2022 were included in analysis of MRSA colonization and infection. The gestational age ranged from 22 weeks to 42 weeks.
INTERVENTIONS: …
Igf-1 Impacts Neocortical Interneuron Connectivity In Epileptic Spasm Generation And Resolution, Carlos J Ballester-Rosado, John T Le, Trang T Lam, Anne E Anderson, James D Frost, John W Swann
Igf-1 Impacts Neocortical Interneuron Connectivity In Epileptic Spasm Generation And Resolution, Carlos J Ballester-Rosado, John T Le, Trang T Lam, Anne E Anderson, James D Frost, John W Swann
Faculty, Staff and Students Publications
Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients' brains. Other studies have reported low levels of the inhibitory neurotransmitter, GABA. In the TTX brain injury model of epileptic spasms, we undertook experiments to evaluate the impact of IGF-1 deficiencies on neocortical interneurons and their role in spasms. Quantitative immunohistochemical analyses revealed that neocortical interneurons that express glutamic acid decarboxylase, parvalbumin, or synaptotagmin 2 co-express IGF-1. In epileptic rats, expression of these three interneuron markers were reduced in the neocortex. …
Analysis Of 1,25-Dihydroxyvitamin D Genomic Action In Human Enteroids And Colonoids Reveals Multiple Regulatory Effects Of Vitamin D In Human Intestinal Physiology, Zachary K Criss, Kali Deans-Fielder, James C Fleet, Sylvia Christakos, Noah Shroyer
Analysis Of 1,25-Dihydroxyvitamin D Genomic Action In Human Enteroids And Colonoids Reveals Multiple Regulatory Effects Of Vitamin D In Human Intestinal Physiology, Zachary K Criss, Kali Deans-Fielder, James C Fleet, Sylvia Christakos, Noah Shroyer
Faculty, Staff and Students Publications
Introduction: The intestine has molecular and functional diversity across the proximal-distal and the crypt-villus axes, so it is imperative to determine the common and compartment-specific molecular actions of vitamin D. However, very little work on vitamin D mediated gene regulation has been done in normal human intestine. Here, we examined the impact of 1,25-dihydroxyvitamin D (1,25(OH)2D3) on cultures of human intestinal epithelium derived from duodenum (Dd) and distal colon (Co) biopsies of 6 subjects per tissue.
Methods: Human enteroids and colonoids were cultured for 3 days to promote a stem cell phenotype (undifferentiated, Un) or to induce differentiation (Diff) and …
Vascularized Iliac Crest Bone Graft For The Reconstruction Of Anterior Vertebral Corpus Defects: A Literature Review And Cadaveric Feasibility Study, Jonathan L Jeger, Casey J Martinez, Maria Shvedova, Alec Simoni, Alanna Rebecca, Sebastian Winocour, Alexander E Ropper, Michael Bohl, William J Casey, Maziyar Kalani, Edward M Reece
Vascularized Iliac Crest Bone Graft For The Reconstruction Of Anterior Vertebral Corpus Defects: A Literature Review And Cadaveric Feasibility Study, Jonathan L Jeger, Casey J Martinez, Maria Shvedova, Alec Simoni, Alanna Rebecca, Sebastian Winocour, Alexander E Ropper, Michael Bohl, William J Casey, Maziyar Kalani, Edward M Reece
Faculty, Staff and Students Publications
BACKGROUND: Vertebral body defects pose a significant challenge in spinal reconstructive surgery. Compression fractures of the vertebral corpus are typically treated with vertebral augmentation procedures. There are significant risks associated with the introduction of foreign material in the spine, including infection and pseudarthrosis. Vascularized bone grafts (VBGs) have become a popular alternative for spinal reconstruction in the last decade thanks to their robust blood supply and autologous nature. VBGs have been described predominantly for the reconstruction of posterior vertebral defects. The objective of this study is to describe a novel procedure for the reconstruction of vertebral corpus defects in the …
Maternal Rest Improves Growth In Small-For-Gestational-Age Fetuses (<10th Percentile), Greggory R Devore, Bardo Polanco, Wesley Lee, Jeffrey Brian Fowlkes, Emma E Peek, Manesha Putra, John C Hobbins
Maternal Rest Improves Growth In Small-For-Gestational-Age Fetuses (<10th Percentile), Greggory R Devore, Bardo Polanco, Wesley Lee, Jeffrey Brian Fowlkes, Emma E Peek, Manesha Putra, John C Hobbins
Faculty, Staff and Students Publications
BACKGROUND: Optimal management of fetuses diagnosed as small for gestational age based on an estimated fetal weight ofHowever, maternal bed rest has not been recommended based on the results of a randomized clinical trial that showed that maternal rest does not improve fetal growth in small-for-gestational-age fetuses. This study was conducted to revisit this question.
OBJECTIVE: This study aimed to determine whether maternal bed rest was associated with an increase in the fetal biometric parameters that reflect growth after the diagnosis of a small-for-gestational-age fetus.
STUDY DESIGN: A retrospective study was conducted on fetuses who were diagnosed as small for …
Thromboelastography Versus Thromboelastometry For Unfractionated Heparin Monitoring In Adult Patients On Extracorporeal Membrane Oxygenation, Ellen B Yin, Arthur W Bracey, Subhasis Chatterjee
Thromboelastography Versus Thromboelastometry For Unfractionated Heparin Monitoring In Adult Patients On Extracorporeal Membrane Oxygenation, Ellen B Yin, Arthur W Bracey, Subhasis Chatterjee
Faculty, Staff and Students Publications
Background: Monitoring the anticoagulant effect of unfractionated heparin (UFH) in extracorporeal membrane oxygenation (ECMO) patients is complex but critically important to balance the risks of treatment related bleeding and circuit thrombosis. While guidelines recommend using more than one method to monitor UFH activity, the use of thromboelastometry (ROTEM) to monitor UFH in ECMO patients has not been investigated in detail.
Methods: This is an observational, single-center retrospective study looking at adult ECMO patients on UFH that had ROTEM and thromboelastography (TEG) tests obtained concurrently. A total of 20 samples were obtained from nine patients during the study period, …
Maintenance Therapy With A P2y12 Receptor Inhibitor After Cangrelor In Patients With Acute Coronary Syndrome The Electra-Sirio 2 Investigators’ Viewpoint, Jacek Kubica, Piotr Adamski, Robert Gajda, Aldona Kubica, Małgorzata Ostrowska, Gavino Casu, Diana A Gorog, Paul A Gurbel, Tomasz Hajdukiewicz, Miłosz Jaguszewski, Young-Hoon Jeong, Agata Kosobucka-Ozdoba, Zuzana Motovska, Piotr Niezgoda, Maciej Piasecki, Przemysław Podhajski, Paolo Raggi, Uzeyir Rahimov, Jolanta M Siller-Matula, Grzegorz Skonieczny, Łukasz Szarpak, Paweł Szymański, Udaya Tantry, Eliano P Navarese
Maintenance Therapy With A P2y12 Receptor Inhibitor After Cangrelor In Patients With Acute Coronary Syndrome The Electra-Sirio 2 Investigators’ Viewpoint, Jacek Kubica, Piotr Adamski, Robert Gajda, Aldona Kubica, Małgorzata Ostrowska, Gavino Casu, Diana A Gorog, Paul A Gurbel, Tomasz Hajdukiewicz, Miłosz Jaguszewski, Young-Hoon Jeong, Agata Kosobucka-Ozdoba, Zuzana Motovska, Piotr Niezgoda, Maciej Piasecki, Przemysław Podhajski, Paolo Raggi, Uzeyir Rahimov, Jolanta M Siller-Matula, Grzegorz Skonieczny, Łukasz Szarpak, Paweł Szymański, Udaya Tantry, Eliano P Navarese
Faculty, Staff and Students Publications
According to the ESC guidelines, cangrelor may be considered in P2Y12-inhibitor-naïve acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The aim of this review is to summarize available evidence on the optimal maintenance therapy with P2Y12 receptor inhibitor after cangrelor. Transitioning from cangrelor to a thienopyridine, but not ticagrelor, can be associated with a drug-drug interaction (DDI); therefore, a ticagrelor loading dose (LD) can be given any time before, during, or at the end of a cangrelor infusion, while a LD of clopidogrel or prasugrel should be administered at the time the infusion of cangrelor ends or within …
The Great Scrape: The Clash Between Scraping And Privacy, Daniel J. Solove, Woodrow Hartzog
The Great Scrape: The Clash Between Scraping And Privacy, Daniel J. Solove, Woodrow Hartzog
Faculty Scholarship
Artificial intelligence (AI) systems depend on massive quantities of data, often gathered by “scraping”—the automated extraction of large amounts of data from the internet. A great deal of scraped data contains people’s personal information. This personal data provides the grist for AI tools such as facial recognition, deep fakes, and generative AI. Although scraping enables web searching, archiving of records, and meaningful scientific research, scraping for AI can also be objectionable and even harmful to individuals and society.
Organizations are scraping at an escalating pace and scale, even though many privacy laws are seemingly incongruous with the practice. In this …
How Theories Of Art Can Inform Debates About Ai, Jessica Silbey
How Theories Of Art Can Inform Debates About Ai, Jessica Silbey
Faculty Scholarship
Debates about artificial intelligence (AI) tend to swing between the optimistic and the apocalyptic. I propose a less binary approach that frames conversations about AI from the perspectives of theories of art and creativity. Whether we agree that AI is artificial or intelligent, whether it should be constrained or liberated, we cannot deny its influence on literary, artistic, and innovative production. AI may be described as simply a new tool to produce art and science, like the camera or the microscope, or it may transform art and science, the way the internet transformed global communication. Either way, these debates about …
Foundations For Platform Liability, Kathryn E. Spier, Rory Van Loo
Foundations For Platform Liability, Kathryn E. Spier, Rory Van Loo
Faculty Scholarship
From spreading misinformation to selling deadly products, bad actors use technology platforms to their advantage while causing devastating harms to privacy, health, and even democracy. Despite their central role in enabling these bad actors, the platforms almost entirely escape liability. This legal immunity is purportedly grounded in economics. From the beginning, courts and legislatures feared that liability would chill innovation, growth, and user access. They also speculated that platforms have sufficient market incentives to voluntarily police bad actors, making liability unnecessary.
Whereas many scholars have argued that platform immunity is blind to justice, this Article shows that it is also …
Measurement Of Spin-Density Matrix Elements In Φ(1020) → K⁰Sk⁰L Photoproduction With A Linearly Polarized Photon Beam At Eˠ = 8.2-8.8 Gev, F. Afzal, C. S. Akondi, M. Albrecht, M. Amaryan, S. Arrigo, V. Arroyave, A. Asaturyan, A. Austegesilo, Z. Baldwin, F. Barbosa, J. Barlow, E. Barringa, R. Barsotti, D. Barton, V. Baturin, V. V. Berdnikov, T. Black, W. Boeglin, M. Boer, W. J. Briscoe, T. Britton, R. Brunner, S. Cao, E. Chudakov, G. Chung, P. L. Cole, O. Cortes, V. Crede, M. M. Dalton, D. Darulis, A. Deur, S. Dobbs, A. Dolgolenko, M. Dugger, R. Dzhygadlo, D. Ebersole, M. Edo, H. Egiyan, T. Erbora, P. Eugenio, A. Fabrizi, C. Fanelli, S. Fang, A. M. Foda, M. Fritsch, S. Furletov, L. Gan, H. Gao, A. Gardner, A. Gasparian, D. I. Glazier, C. Gleason, V. S. Goryachev, B. Grube, J. Guo, L. Guo, J. Hernandez, K. Hernandez, N. D. Hoffman, D. Hornidge, G. Huber, P. Hurck, W. Imoehl, D. G. Ireland, M. M. Ito, I. Jaegle, N. S. Jarvis, T. Jeske, M. Jing, R. T. Jones, V. Kakoyan, G. Kalicy, V. Khachatryan, C. Kourkoumelis, A. Laduke, I. Larin, D. Lawrence, D. I. Lersch, H. Li, B. Liu, K. Livingston, L. Lorenti, V. Lyubovitskij, A. Mahmood, H. Marukyan, V. Matveev, M. Mccaughan, M. Mccracken, C. A. Meyer, R. Miskimen, R. E. Mitchell, K. Mizutani, P. Moran, V. Neelamana, L. Ng, E. Nissen, S. Orešić, A. I. Ostrovidov, Z. Papandreou, C. Paudel, R. Pedroni, L. Pentchev, K. J. Peters, E. Prather, L. Puthiya Veetil, S. Rakshit, J. Reinhold, A. Remington, B. G. Ritchie, J. Ritman, G. Rodriguez, D. Romanov, K. Saldana, C. Salgado, S. Schadmand, A. M. Schertz, K. Scheuer, A. Schick, A. Schmidt, R. A. Schumacher, J. Schwiening, M. Scott, N. Septian, P. Sharp, V. Shen, X. Shen, M. R. Shepherd, J. Sikes, A. Smith, E. S. Smith, D. I. Sober, A. Somov, S. Somov, J. R. Stevens, I. I. Strakovsky, B. Sumner, K. Suresh, V. V. Tarasov, S. Taylor, A. Teymurazyan, A. Thiel, T. Viducic, T. Whitlatch, N. Wickramaarachchi, Y. Wunderlich, B. Yu, J. Zarling, Z. Zhang, X. Zhou, B. Zihlmann
Measurement Of Spin-Density Matrix Elements In Φ(1020) → K⁰Sk⁰L Photoproduction With A Linearly Polarized Photon Beam At Eˠ = 8.2-8.8 Gev, F. Afzal, C. S. Akondi, M. Albrecht, M. Amaryan, S. Arrigo, V. Arroyave, A. Asaturyan, A. Austegesilo, Z. Baldwin, F. Barbosa, J. Barlow, E. Barringa, R. Barsotti, D. Barton, V. Baturin, V. V. Berdnikov, T. Black, W. Boeglin, M. Boer, W. J. Briscoe, T. Britton, R. Brunner, S. Cao, E. Chudakov, G. Chung, P. L. Cole, O. Cortes, V. Crede, M. M. Dalton, D. Darulis, A. Deur, S. Dobbs, A. Dolgolenko, M. Dugger, R. Dzhygadlo, D. Ebersole, M. Edo, H. Egiyan, T. Erbora, P. Eugenio, A. Fabrizi, C. Fanelli, S. Fang, A. M. Foda, M. Fritsch, S. Furletov, L. Gan, H. Gao, A. Gardner, A. Gasparian, D. I. Glazier, C. Gleason, V. S. Goryachev, B. Grube, J. Guo, L. Guo, J. Hernandez, K. Hernandez, N. D. Hoffman, D. Hornidge, G. Huber, P. Hurck, W. Imoehl, D. G. Ireland, M. M. Ito, I. Jaegle, N. S. Jarvis, T. Jeske, M. Jing, R. T. Jones, V. Kakoyan, G. Kalicy, V. Khachatryan, C. Kourkoumelis, A. Laduke, I. Larin, D. Lawrence, D. I. Lersch, H. Li, B. Liu, K. Livingston, L. Lorenti, V. Lyubovitskij, A. Mahmood, H. Marukyan, V. Matveev, M. Mccaughan, M. Mccracken, C. A. Meyer, R. Miskimen, R. E. Mitchell, K. Mizutani, P. Moran, V. Neelamana, L. Ng, E. Nissen, S. Orešić, A. I. Ostrovidov, Z. Papandreou, C. Paudel, R. Pedroni, L. Pentchev, K. J. Peters, E. Prather, L. Puthiya Veetil, S. Rakshit, J. Reinhold, A. Remington, B. G. Ritchie, J. Ritman, G. Rodriguez, D. Romanov, K. Saldana, C. Salgado, S. Schadmand, A. M. Schertz, K. Scheuer, A. Schick, A. Schmidt, R. A. Schumacher, J. Schwiening, M. Scott, N. Septian, P. Sharp, V. Shen, X. Shen, M. R. Shepherd, J. Sikes, A. Smith, E. S. Smith, D. I. Sober, A. Somov, S. Somov, J. R. Stevens, I. I. Strakovsky, B. Sumner, K. Suresh, V. V. Tarasov, S. Taylor, A. Teymurazyan, A. Thiel, T. Viducic, T. Whitlatch, N. Wickramaarachchi, Y. Wunderlich, B. Yu, J. Zarling, Z. Zhang, X. Zhou, B. Zihlmann
Physics Faculty Publications
We measure the spin-density matrix elements (SDMEs) for the photoproduction of 𝜙(1020) off of the proton in its decay to 𝐾0𝑆𝐾0𝐿, using 105 pb−¹ of data collected with a linearly polarized photon beam using the GlueX experiment. The SDMEs are measured in nine bins of the squared four-momentum transfer 𝑡 in the range −𝑡=0.15−1.0 GeV², providing the first measurement of their 𝑡 dependence for photon beam energies of 𝐸𝛾=8.2−8.8 GeV. We confirm the dominance of Pomeron exchange in this region and put constraints on the contribution of other Regge exchanges. We also …
Small-X Gluon Gpd Constrained From Deeply Virtual J/Ψ Production And Gluon Pdf Through Universal-Moment Parametrization, Yuxun Guo, Xiangdong Ji, M. Gabriel Santiago, Jinghong Yang, Hao-Cheng Zhang
Small-X Gluon Gpd Constrained From Deeply Virtual J/Ψ Production And Gluon Pdf Through Universal-Moment Parametrization, Yuxun Guo, Xiangdong Ji, M. Gabriel Santiago, Jinghong Yang, Hao-Cheng Zhang
Physics Faculty Publications
We phenomenologically constrain the small-x and small-𝜉 gluon generalized parton distributions (GPDs) with the deeply virtual J/ψ production (DVJ/ψP) in the framework of GPDs through universal moment parameterization (GUMP). We use a hybrid cross-section formula combining collinear factorization to the next-to-leading order (NLO) accuracy of the strong coupling 𝛼s, with corrections from nonrelativistic QCD to account for the power corrections due to the heavy J/ψ mass. We reach reasonable fit to the measured differential cross sections of DVJ/ψP by H1 at the Hadron-Electron Ring Accelerator as well as forward gluon parton distribution functions (PDFs) from JAM22 global analysis. …