Digital Commons Network^™

Central Obesity Is An Independent Determinant Of Advanced Fibrosis In Lean Patients With Nonalcoholic Fatty Liver Disease, Arka De, Naveen Bhagat, Manu Mehta, Priya Singh, Sahaj Rathi, Nipun Verma, Sunil Taneja, Madhumita Premkumar, Ajay Duseja

Faculty, Staff and Students Publications

Background: The current definition of lean is based on body mass index (BMI). However, BMI is an imperfect surrogate for adiposity and provides no information on central obesity (CO). Hence, we explored the differences in clinical profile and liver disease severity in lean patients with nonalcoholic fatty liver disease (NAFLD) with and without CO.

Methods: One hundred seventy lean patients with NAFLD (BMI < 23 kg/m2) were divided into two groups depending upon the presence or absence of CO (waist circumference ≥80 cm in females and ≥90 cm in males). Noninvasive assessment of steatosis was done by ultrasound and controlled attenuation parameter (CAP), while fibrosis was assessed with FIB-4 and liver stiffness measurement (LSM). FibroScan-AST (FAST) score was used for non-invasive prediction of NASH with significant fibrosis.

Results: Of 170 patients with lean NAFLD, 96 (56.5%) had CO. Female gender (40.6% vs. 17.6%, P = 0.001), hypertriglyceridemia (58.3% vs. 39.2%, P = 0.01) and metabolic syndrome (23.9% vs. 4.1%, P < 0.001) were more common in the CO group. There was a poor correlation between BMI and waist circumference (r = 0.24, 95% CI: 0.09-0.38). Grade 2-3 steatosis on ultrasound was significantly more common in CO patients (30% vs. 12.3%, P = 0.007). CAP …

Critiques Of The Cass Review: Fact-Checking The Peer-Reviewed And Grey Literature, Kathleen Mcdeavitt, J Cohn, Stephen B Levine

Faculty, Staff and Students Publications

The Cass Review's final report, published in April 2024, made recommendations to the UK's National Health Service regarding structuring of services for minors with gender-related distress. It recommended cautious use of hormonal interventions in this population and use of research protocols. Some clinician-researchers disagree with the Cass Review's recommendations and have written critiques. A critique of the Cass Review posted on Yale Law School's website in July 2024 has received extensive media coverage. Its references identified three other critiques. In these papers, there were multiple claims that were incorrect or that lacked essential clarification/contextualization. These claims involved (1) the Cass …

Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici

Faculty, Staff and Students Publications

Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections continue to occur in vaccinated individuals, contributing to further viral mutation and spread. These limitations may be attributable to the poor induction of mucosal immunity by parenteral vaccination. Mucosal adjuvants, such as T-vant, can enhance vaccine-induced immune responses through the generation of antigen-specific antibodies and T cells in the respiratory tract. In this study, we evaluated the protective efficacy of adjuvanted SARS-CoV-2 receptor binding domain (RBD) subunit vaccines administered by homologous and heterologous routes. Immunized mice were challenged with …

Purely Cystic Intraosseous Meningioma Of The Skull: A Radiologic Conundrum And Histologic Challenge, Diego Rojas, Arman Kavoussi, Ashley Rose Ricciardelli, Alex Flores, Sricharan Gopakumar, Luis Carrete, Hsiang-Chih Lu, Alex W Brenner, Akash J Patel

Faculty, Staff and Students Publications

Background: Intraosseous meningiomas and cystic meningiomas are two rare subtypes of meningiomas. Meningiomas can develop with characteristics encompassing both cystic and intraosseous, termed intraosseous cystic meningiomas, that pose a diagnostic challenge.

Case description: We report the case of a 41-year-old woman with a history of hearing loss presented with a left frontal mass that had been present for 12 years. Her history of hearing loss was in the setting of ear infections bilaterally since she was a teenager and was being evaluated by ear, nose, and throat specialists at the time. Initial cranial computed tomography (CT) identified a skull lesion …

Opsoclonus In Alternating Hemiplegia Of Childhood Secondary To Atp1a3 Pgly803arg, Alyssa D Runco, Jesse M Levine, Cristina Trandafir, Rod Foroozan, Mered Parnes, Daniel G Calame

Faculty, Staff and Students Publications

No abstract provided.

Ai Literacy For All: A Universal Framework, Leo S. Lo

University Libraries & Learning Sciences Faculty and Staff Publications

Artificial intelligence has become a pervasive force shaping society, economy, and daily life. Despite widespread media coverage and business adoption, a significant gap persists between superficial awareness and meaningful understanding of AI's principles, ethical dimensions, and societal implications. This paper introduces AI Literacy for All: A Universal Framework, a comprehensive model designed to foster responsible engagement with AI across diverse populations.

The framework integrates five essential components—Technical Knowledge, Ethical Awareness, Critical Thinking, Practical Use, and Societal Impact—each structured into four progressive levels guiding learners from basic awareness to strategic insight. This design balances accessible technical understanding with ethical reasoning, critical …

Leveraging Human Microbiomes For Disease Prediction And Treatment, Henok Ayalew Tegegne, Tor C Savidge

Faculty, Staff and Students Publications

The human microbiome consists of diverse microorganisms that inhabit various body sites. As these microbes are increasingly recognized as key determinants of health, there is significant interest in leveraging individual microbiome profiles for early disease detection, prevention, and drug efficacy prediction. However, the complexity of microbiome data, coupled with conflicting study outcomes, has hindered its integration into clinical practice. This challenge is partially due to demographic and technological biases that impede the development of reliable disease classifiers. Here, we examine recent advances in 16S rRNA and shotgun-metagenomics sequencing, along with bioinformatics tools designed to enhance microbiome data integration for precision …

Difficulties In Diagnosing Lactose Malabsorption, Richard Kellermayer

Faculty, Staff and Students Publications

No abstract provided.

Human Factors Matter: The Intersection Of Cybersecurity Governance, And Culture In Risk Management Of Critical Infrastructure, Prince Abubakari

Theses and Dissertations

In the 21st century, cybersecurity threats have evolved into pressing socio-technical issues, with significant implications for the safety and stability of global critical infrastructure. This dissertation explores the intersection of cybersecurity governance and culture in risk management of national critical infrastructures, defined as essential systems and assets, whether physical or virtual, that are vital to the security, public health, safety, economy, or any combination thereof, and the disruption of which would have a debilitating impact on a nation. The study delves into how human factors like organizational culture and governance mechanisms interplay to influence cybersecurity outcomes. The research adopts a …

A Systematic Review Of Novice Registered Nurses’ Experiences With Mentorship Programs, Shay Riker

Theses and Dissertations

Novice registered nurses face many challenges as they transition into clinical practice. Switching from a student role characterized by supervision and support to one in which they are fully responsible for patient care can be daunting for newly graduated registered nurses. Practicing nurses transitioning into a different specialization of nursing may also perceive themselves as inadequately equipped to manage clinical situations, resulting in self-doubt and anxiety. Both novice registered nurse groups encounter difficulties in prioritizing care, managing time, and adapting to the dynamics of a new role and work environment. Mentorship programs are essential in facilitating the transition of novice …

Mapping Reputational Shifts: Lessons From U.S. Professional Sports Communities During The Black Lives Matter Social Crisis, Dean Austin Hess Iii

Theses and Dissertations

From 2013 through 2024, the Black Lives Matter (BLM) social crisis had profound impacts on major U.S. professional sports communities. Prior crisis research has concentrated on the BLM-related player protests in the National Basketball Association (NBA) and the National Football League (NFL) over momentary periods of upheaval. Based on a review of crisis response and communication literature and its application to sports, this research offers a previously missing longitudinal account of how major professional sports communities (i.e., NBA, NFL, MLB, MLS, NHL, and NASCAR) responded to the BLM social crisis. It aims to offer a better understanding of community group …

Best Practices For Addressing Invisible Labor Among Black Faculty At Predominately White Institutions, Candice Raynor

Theses and Dissertations

The focus of this research was on challenges impacting Black professors obtaining tenure, with the goal of establishing best practices aimed at preventing and addressing these challenges. The approach was conducting an assessment of race-related obstacles Black professors encountered at predominately White postsecondary colleges and universities. A review of the existing literature found that invisible labor, also known as cultural taxation, has long existed in the academy and has been documented in several studies. Cultural taxation is a term coined early in the 1990s to describe labor that is expected to be performed by someone because of their racial identity, …

Refining Albert O. Hirschman’S Model: High-Performance Employee Covert Behavior Toward Organizational Identity Change, Lisa Christine Bahar

Theses and Dissertations

This explanatory single case study revisited economist and philosopher Albert O. Hirschman’s (1970) exit, voice, and loyalty (EVL) model to explore two covert scenarios, which included how and why a high-performance employee stays silent and turns to apathy and neglect amid organizational identity change. A case study focused on Elon Musk’s Twitter, Inc. takeover was selected with a cross-case analysis procedure for validation and reliability. The unit of analysis was one high-performance employee and one organization that both served as an archetype for each unit. The study focused on occurrences before and during the takeover from June 2019 through July …

Project Hope: The Impact Of Coaching And Transformation Among Returning Citizens, Mark Keven Cox

Theses and Dissertations

The study of psychological transformation within the prison context appears nascent with few academic articles to be found on the subject. The few that do exist suggest that transformation in the prison context is possible. Drawing from the academic literature regarding psychological transformation, inclusive of Hope Theory and Self-efficacy Theory, this qualitative research sought to understand how cognitive coaching programs within United States prisons may foster psychological transformation and increased likelihood of societal reentry success for returning citizens. The research sits at the intersection of coaching and theories associated with psychological transformation and explores the consequences of a single carceral-based …

Millennial Leadership Practices: How Are They Choosing To Lead Using The Lens Of Their Managerial Style, Claudia Helen Hesky Archibald

Theses and Dissertations

Despite millennials comprising over one-third of the current workforce, empirical research regarding their leadership practices remains limited. This study aimed to address this gap by investigating: (1) the preferred leadership practices of millennial leaders, and (2) whether millennial characteristics indicate a preference for specific leadership styles. Data were collected from 48 millennial leaders in the United States through online surveys, supplemented by 16 virtual interviews. The analysis revealed that millennial leadership practices, consistent with servant leadership principles, emphasized empowerment and delegation, relationship and community building, and trust cultivation.

Identifying The Best Practices Of Wilderness-Immersion Programs To Support Veterans’ Transition From The Military To College, Catkin Kilcher Burton

Theses and Dissertations

This study identified best practices for designing and implementing wilderness-immersion programs to support student veterans transitioning from military service to college. It used a sequential explanatory mixed-methods design. Phase 1 of the study involved a Delphi approach wherein an expert panel of program facilitators, university staff, mental health providers, and student veterans rated and refined an initial set of best practices drawn from literature. Veterans Affairs directors provided feedback in a focus group format to refine the framework. This study contributes practical, evidence-based guidelines to enhance the academic, social, and emotional success of student veterans through wilderness-immersion interventions. Findings from …

Strategic Military Readiness: Navigating Knowledge Management In The United States Army, Blaine Andra White

Theses and Dissertations

This was a qualitative phenomenological study of knowledge management (KM) in the U.S. Army. The study explored the KM phenomenon by interviewing retired highly experienced field-grade Army commissioned and non-commissioned officers (NCOs), with varying backgrounds in combat, combat support, and combat service support branches. The research sought to address the problem of a discernable gap in the understanding among Army leaders regarding the effective utilization of KM staff for their units to employ the KM process effectively. This study's two central research questions (RQ) were RQ1: What targeted strategies can be developed for Army leaders and their subordinate units to …

High School Counselor Perceptions Of Trauma-Informed Professional Development And Implementation Of Trauma-Informed Practices In Schools, Kimberly Faulkner-Camacho

Theses and Dissertations

This non-experimental phenomenological study aimed to delve into school counselors’ perspectives on what motivates them to participate in trauma-informed professional development, the necessary supports for implementing trauma-informed practices in schools (TIPS), and the barriers that impede implementation. Drawing on situated learning theory and adult learning theory, this study sought to enhance the understanding of school counselors’ views on trauma-informed professional development and implementation. These frameworks offered valuable insights into how to support counselors and shed light on existing barriers. The study involved 10 traditional public high school counselors from non-charter schools in Los Angeles County, selected through snowball and purposive …

Analysis Of Dual Roles: Work-Life Balance Experiences Of Female Professors And Mothers In California, Lu Liang

Theses and Dissertations

The study aims to discover and understand the work-life balance experience of mothers who are also professors working in higher education institutions in California. The research reveals the unique challenges, needs, and motivations to manage work and family responsibilities. The literature review indicates that mother professors encounter conflicts of roles and responsibilities from academic work and domestic duties. Moreover, mother professors experience persistent gender disparity and systemic barriers as an underrepresented group in academia, hindering their personal and professional advancements. This qualitative study utilizes quantitative ethnography (QE), an incorporated research methodology to examine mother professors’ work-life balance experience. Additionally, the …

Black Adolescents' Mental Health And Identity Formation: The Role Of Discrimination And Racial Socialization - A Systematic Review, Tsahai Jenkins

Theses and Dissertations

This systematic review examines the impact of racial discrimination on mental health and racial identity development among Black adolescents, focusing on anxiety, depression, self-esteem, and identity formation, as well as the protective role of racial socialization. Analysis of 19 qualitative and quantitative studies revealed that Black adolescents frequently experience discrimination across various settings, including schools, public spaces, and online platforms, with significant effects on mental health and self-concept. Gendered patterns were evident, with females more likely to internalize stress as anxiety and depression, while males showed externalizing behaviors such as aggression. Racial socialization, especially cultural pride messages, emerged as a …

Consumer Satisfaction & Complaint Resolution In The Los Angeles Home Improvement Industry, Aimee Joy

Theses and Dissertations

Home has many layers of meaning as does the term, home improvement. The first and most common way of thinking about home is the structure in which we reside. For decades the American dream has involved home ownership. It is important to understand both the emotional and financial value of having a shelter and structure to call home. Losing this can be one of the most stressful events in life. The fires in Los Angeles County during the beginning of 2025 impacted thousands of people. Individuals, families, and communities were disrupted and forced to rebuild as well as reconsider what …

The Assessment Of Implicit Bias Among Police Personnel: A Systematic Review, Emily Deutsch

Theses and Dissertations

Due to the essential and powerful role police officers play within the communities they serve, systematic racism in law enforcement has become a key topic of public discourse, including increased demand for evidence-based changes in police selection. This includes recommendations or requirements to assess implicit bias in police candidates (e.g., California Assembly Bill 846). Implicit bias refers to the spontaneous/automatic associations or evaluations made of members of a particular group (Kim & Roberson, 2021). The California Commission on Peace Officer Standards and Training’s (POST’s) Bias Assessment Framework provides recommendations to police psychologists on the assessment of implicit bias, but curiously …

Polarization And Civil Discourse In America: A Case Study Of Respectful Dialogue As A Moderating Influence On Generation Z, Liane Weintraub

Theses and Dissertations

Animosity between opposing political parties is longstanding, but the phenomenon is now acutely pervasive and dangerous. Today, polarization is further fueled by social media algorithms that create echo chambers, limiting discourse about diverse viewpoints. Consequently, polarization has become pernicious and threatens the founding principles of American democracy. This dissertation considers the roles of free speech, civility, and social capital in the US polarization problem. Through an exploration of historical scholarship on virtue, ethics, and civility, the study seeks to identify actionable tools for promoting civil discourse. The dissertation investigates Generation Z (Gen Z), focusing on intergenerational differences, the role of …

A Systematic Review Of The Outcomes And Efficacy Of Complementary And Alternative Non-Pharmacological Interventions In Youth With Attention Deficit Hyperactivity Disorder, Kelly M. Kohler

Theses and Dissertations

A number of behavioral and pharmacological treatments have been widely accepted as evidenced-based approaches to treating symptoms of attention-deficit hyperactivity disorder (ADHD) in children and adolescents. While pharmacological approaches are safe and effective at managing symptoms, a large subset of caregivers do not have access to medication, refuse it, or find it ineffective, necessitating the need for non-pharmacological treatments. Such behavioral interventions are also generally effective approaches to symptom management and reducing the functional impairment of ADHD and may even demonstrate better parent satisfaction than medication alone. However, these interventions are often difficult to access and burdensome to implement, especially …

Assessing The “Plateaus” Vertical Development Model With A New Likert Scale Instrument, Mark Divine

Theses and Dissertations

This research project will focus on the assessment of the Five Plateaus (Plateaus) vertical leadership development model with a newly constructed Likert Scale instrument. Part one of the research project was a pilot study to create a simple, internet-based instrument. The scale, comprised of 100 questions and completed in 30 minutes, assesses participants' self- perceived stage of development as presented in the Plateaus vertical development model. The instrument was designed to capture the experience of participants and to overcome limitations of existing assessments by mitigating the subjectivity of sentence completion instruments, as well as to enhance efficiency and reliability. The …

Culturally Specific Interventions And Indigenous Practices In Correctional And Forensic Settings: A Systematic Review, Jordyne James

Theses and Dissertations

While professional guidelines, legislation and research emphasize the importance of adapting treatment approaches to patient characteristics and culture (American Psychological Association [APA], 2021, 2019; Correctional Service of Canada [CSC], 2013; Canadian Psychological Association [CPA], 2017; Canadian Counseling and Psychotherapy Association [CCPA], 2021), psychological and forensic research and practice related to culturally specific programming lags behind expectations to meet the needs of ethnically diverse clients. Given the continued overrepresentation of minorities within forensic institutions (Aguiar, 2020; Carter & Forsyth, 2007; Hanser & Gomila, 2015; Leguizamo et al., 2018), this systematic review aimed to raise awareness of culturally-specific interventions and Indigenous practices …

The Cognitive And Positive Aspects Of Language Brokering Among Latinx Individuals: An Integrative Systematic Review, Jacqueline Juarez

Theses and Dissertations

English has been the prominent language spoken in the United States; however, with the rise of the Spanish language, it is imperative to address how Spanish speakers navigate spaces. Research has found mixed findings about the outcomes of serving as a language broker. This integrative systematic review aimed to identify and analyze literature on Latinx language brokers regarding cognitive strategies and abilities and the positive processes and perceptions that contribute to enhancing mental health. This review also sought to focus on factors that may contribute to resiliency over time for Latinx language brokers. A total of 31 studies were included …

Psychopathology, Symptomology, And Treatment In Offspring Of Holocaust Survivors: An Integrative Systematic Review, Lauren Grace Escobar

Theses and Dissertations

This systematic review aimed to evaluate the symptomatology, psychopathology, and treatment of offspring of Holocaust survivors (OHS). A comprehensive search was conducted in PsycINFO, PILOTS/PTSD, and Scopus for studies published between 1990 and 2024. Inclusion criteria required peer-reviewed studies, reports, books, literature reviews, and meta-analyses written or translated into English that reported on symptomatology and treatment for OHS. From an initial yield of 2,532 articles, 119 studies met the inclusion criteria. The findings suggest that OHS demonstrate significantly higher levels of symptomatology and psychopathology reported in nine clinical classifications. Psychodynamic treatment was the most commonly found treatment modality for OHS, …

Symptom Presentations And Effective Mental Health Interventions For Those Experiencing Homelessness: A Systematic Review, Abraham Sloves

Theses and Dissertations

Homelessness is a present and concerning issue without a clear solution due partly to barriers in public policy, as well as challenges in homelessness research. Research seems to indicate that barriers to effective research on homelessness include inconsistent and incomplete data on homelessness prevalence, a lack of consistency in defining homelessness, and lack of generalizable research (Hossain et al., 2020). This is especially true when it comes to the intersection between homelessness and mental illness. While research has been done on interventions for unhoused individuals (Morton et al., 2020; Ponka et al., 2020), studies often fail to address the complex …

The Use Of Humor In Mental Healthcare: A Systematic Review, Blake Song

Theses and Dissertations

Humor has been observed, practiced, and documented as an essential feature of society for thousands of years. However, there is still no formalized or widely referenced clinical guidance on how to effectively and appropriately utilize humor in mental healthcare despite ample research over the last 70 years noting the many potential benefits. This lack of guidance may, at least in part, be due to unresolved concerns pertaining to the use of humor in counseling and healthcare settings. For instance, humor is believed by some to be potentially distracting or undermining to the counseling process if used inappropriately. This continued absence …