Digital Commons Network^™

Functional Roles Of The Complement Immune System In Cardiac Inflammation And Hypertrophy, Kathryn D Hok, Haydn E Rich, Anthony Shadid, Lavanya Gunamalai, Tingting Weng-Mills, Rajarajan A Thandavarayan, Nirmal K Banda, Marie-Francoise Doursout, Marcos I Restrepo, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Cardiac inflammation and hypertrophy develop as a pathologic response to an array of insults, such as myocardial infarctions, chronic systemic hypertension, and valvular defects. Due to the high prevalence of such conditions, there is an increasing need to prevent and halt cardiac hypertrophy. Because cardiac damage and subsequent remodeling can lead to arrhythmias, heart failure, and even sudden cardiac death, inhibition of cardiac hypertrophy is key to reducing cardiovascular-related mortality. The immune system is the driving force behind inflammatory reactions. All three pathways of complement system activation-classical, lectin, and alternative-are implicated in developing cardiac damage, inflammation, and hypertrophy due to …

Emotional Intelligence Training Correlates With Medical Students’ Apprehension Of Ai In Healthcare: A Single-Institution, Observational Study, Austin P. Runde, Shambhavi Mishra, Marina Feffer, Ramzan Shahid

School of Medicine

Background: The use of artificial intelligence (AI) in healthcare is becoming increasingly widespread. While AI has been touted to improve many aspects of the field, its potential to undermine the doctor-patient relationship has also been recognized. It is not known what future physicians believe regarding the potential effects of AI on physicians' professional relationships. It is also unknown whether formal training in emotional intelligence (EI) and resilience strategies influences medical students' opinions on the use of AI in healthcare.

Objective: To ascertain medical students’ opinion on the potential impact of AI on various EI-related aspects of healthcare, such as its …

Establishing Priority Pediatric Antimicrobial Stewardship Interventions In The Us: Findings From A Delphi Consensus Study., Harry Obeng, Emmanuel Tetteh, Sara Malone, Lauren Walsh, Tyler Walsh, Fernando J. Bula-Rudas, Ritu Banerjee, Adam W. Brothers, Joshua C. Herigon, Katie Namtu, Scott Weissman, Daniel Riggsbee, Jared Olson, Debra Lynn Palazzi, Ann L. Wirtz, Matthew Sattler, Jessica Tansmore, Brittany A. Rodriguez, Monica Abdelnour, Joshua R. Watson, Alison C. Tribble, Jessica Gillon, Mari Nakamura, Sarah Jones, Jason G. Newland, Virginia R. Mckay

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND/OBJECTIVES: Antimicrobial resistance (AMR) is a major global health threat, with children at higher risk due to developmental differences in drug metabolism, limited treatment options and inappropriate antibiotic use. Pediatric antimicrobial stewardship programs (ASPs) face implementation challenges, often relying on adult-based guidelines and limited pediatric-specific evidence. This study aimed to identify and prioritize the most critical areas for pediatric ASP intervention development through a structured, multi-round Delphi consensus process with experts in antimicrobial stewardship and infectious diseases.

METHOD: A four-round modified Delphi process was conducted to identify and prioritize key pediatric ASP interventions. Experts in antimicrobial stewardship and infectious diseases …

Establishing Priority Pediatric Antimicrobial Stewardship Interventions In The Us: Findings From A Delphi Consensus Study, Harry Obeng, Emmanuel Tetteh, Sara Malone, Matthew Sattler, Monica Abdelnour, Virginia R Mckay, Et Al.

2020-Current year OA Pubs

BACKGROUND/OBJECTIVES: Antimicrobial resistance (AMR) is a major global health threat, with children at higher risk due to developmental differences in drug metabolism, limited treatment options and inappropriate antibiotic use. Pediatric antimicrobial stewardship programs (ASPs) face implementation challenges, often relying on adult-based guidelines and limited pediatric-specific evidence. This study aimed to identify and prioritize the most critical areas for pediatric ASP intervention development through a structured, multi-round Delphi consensus process with experts in antimicrobial stewardship and infectious diseases.

METHOD: A four-round modified Delphi process was conducted to identify and prioritize key pediatric ASP interventions. Experts in antimicrobial stewardship and infectious diseases …

Establishing Priority Pediatric Antimicrobial Stewardship Interventions In The Us: Findings From A Delphi Consensus Study, Harry Obeng, Emmanuel Tetteh, Sara Malone, Lauren Walsh, Tyler Walsh, Fernando J Bula-Rudas, Ritu Banerjee, Adam W Brothers, Joshua C Herigon, Katie Namtu, Scott Weissman, Daniel Riggsbee, Jared Olson, Debra Lynn Palazzi, Ann Wirtz, Matthew Sattler, Jessica Tansmore, Brittany A Rodriguez, Monica Abdelnour, Joshua R Watson, Alison C Tribble, Jessica Gillon, Mari Nakamura, Sarah Jones, Jason G Newland, Virginia R Mckay

Faculty, Staff and Students Publications

Background/objectives: Antimicrobial resistance (AMR) is a major global health threat, with children at higher risk due to developmental differences in drug metabolism, limited treatment options and inappropriate antibiotic use. Pediatric antimicrobial stewardship programs (ASPs) face implementation challenges, often relying on adult-based guidelines and limited pediatric-specific evidence. This study aimed to identify and prioritize the most critical areas for pediatric ASP intervention development through a structured, multi-round Delphi consensus process with experts in antimicrobial stewardship and infectious diseases.

Method: A four-round modified Delphi process was conducted to identify and prioritize key pediatric ASP interventions. Experts in antimicrobial stewardship and infectious diseases …

The Impacts Of Chronic Infections On Shaping Cellular Senescence, Ashley Johnson, Troy Rought, Jacob Aronov, Princess Pokharel, Angelina Chiu, Azadeh Nasuhidehnavi

Pharmacy Faculty Scholarship

Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype. While senescence is traditionally associated with aging, growing evidence reveals that chronic infections such as viral, bacterial, and protozoan parasites can serve as powerful inducers of senescence, contributing to premature aging and long-term tissue damage. This review explores the diverse mechanisms by which persistent pathogens trigger or sustain senescence in host cells. We highlight how these chronic infections manipulate host DNA repair, mitochondrial dynamics, telomere maintenance, oxidative stress, and immune function to promote senescence and immunosenescence. Emerging …

Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman

Student Papers, Posters & Projects

The BCL2 family of proteins plays a pivotal role in regulating apoptosis and cellular homeostasis, making them critical therapeutic targets in cancer and other diseases characterized by pathological cell survival. BH3 mimetics, small molecules that selectively inhibit anti-apoptotic BCL2 family members, have achieved significant clinical success, particularly in hematologic malignancies. However, several challenges remain, including resistance mechanisms, toxicity (such as MCL1 inhibitor-associated cardiotoxicity), and the intricate balance between apoptotic and non-apoptotic functions. This review provides a comprehensive overview of BCL2 family biology, the development and clinical application and outcomes of BH3 mimetics, and the emerging resistance mechanism known as double-bolt …

Vaccine And Treatment Evaluation Units: A Historical Perspective, Robert B Belshe, David I Bernstein, Kathryn M Edwards, Sharon E Frey, Wendy A Keitel, Myron M Levine, John J Treanor, Peter F Wright

Faculty, Staff and Students Publications

On 27 February 1962, Surgeon General Luther Terry announced a new vaccine development program within the National Institute of Allergy and Infectious Diseases (NIAID). Initially, the plan had three components: (1) special laboratories and facilities for development of prototype vaccines; (2) pilot lot production facilities and preliminary vaccine trial sites; and (3) larger lot production capacity and expanded human testing. Respiratory viruses were targeted as the top priority for vaccine development. Over 5 decades, this program has evolved and expanded to include multiple academic vaccine evaluation sites within the network, now labeled as the Vaccine and Treatment Evaluation Units (VTEUs). …

2014 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2008 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2005 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Simulasi Kenaikan Tarif Cukai Rokok Terhadap Kinerja Ekonomi Rokok Di Indonesia, Diska Agustinningtyas, Neli Agustina

Jurnal Ekonomi dan Pembangunan Indonesia

Production and consumption of cigarettes in Indonesia tend to increase. Increasing production has a positive impact on state revenue. However, the increasing consumption of cigarettes harms public health. The government implemented a policy of cigarette excise tax to control cigarette consumption. This study aims to analyze the impact of increasing the cigarette tax on the economic performance of the cigarette industry. Using Two-Stage Least Squares (2SLS) estimation methods shows that cigarette production is influenced by its consumption. Cigarette consumption is influenced by its price, per capita income in the previous year, and its consumption in the previous year. Cigarette’s price …

A Quantitative Analysis Of Postmarketing Safety Events Of Breakthrough Medicines, Richard Judson Davis

Walden Dissertations and Doctoral Studies

Adverse events to medicines pose a risk to the public health of patients. Breakthrough therapy medicines are designed to address unmet medical needs and are often approved on an expedited timeline; however they are also criticized for lacking an adequate understanding of their risk profile at the time of approval. This study examined the relationship between the number of concomitant medicines, as well as the approved therapeutic indication, and the outcomes of reported adverse events associated with medicines approved under the breakthrough therapy designation. The conceptual framework applied in this retrospective, cross-sectional, quantitative study is the process of pharmacovigilance, which …

Client And Clinician Priorities For Same-Day Prep And Doxy-Pep Awareness, Uptake, And Persistence In Primary Care, Nathaniel Albright

Dissertations

Approximately 70% of all new human immunodeficiency virus (HIV) infections are among populations of sexual and gender minorities (SGM) and are primarily attributable to sexual contact. Currently, only 26% of the U.S. population who would benefit from HIV preexposure prophylaxis (PrEP) are prescribed this effective biomedical HIV prevention strategy. Biomedical prevention strategies for bacterial sexually transmitted infections (STI) like doxycycline postexposure prophylaxis (doxy-PEP), are a vital component to the successes of ending the HIV epidemic given the well-known association between STIs and risk for HIV infection. In this multiple methods study, we leveraged group concept mapping and conducted focus groups …

Trajectory Of Tinnitus Distress Across The Covid-19 Pandemic: A Cross-Sectional Analysis Of Self-Reported Symptoms, Anusha Yellamsetty, Mika Shin

Faculty Research, Scholarly, and Creative Activity

Purpose: This study aimed to evaluate retrospectively self-reported changes in tinnitus severity and distress associated with the COVID-19 pandemic and vaccination using validated self-report instruments. It further explored patient-reported onset of tinnitus following vaccination, gender differences in symptom severity, and associations with psychological distress. Method: A cross-sectional online survey was completed by 189 adults between December 2023 and April 2024. Participants retrospectively self-reported tinnitus onset and severity before, during, and after the COVID-19 pandemic using the Tinnitus Handicap Inventory (THI) and the Tinnitus Reaction Questionnaire (TRQ). Additional items assessed COVID-19 vaccination history, infection status, and adverse vaccine reactions. Repeated measures …

The Minutes Of The Marshall University Board Of Governors Meeting, October 08, 2025, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo

School of Graduate Studies Faculty Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …

A Comparison Of Deep Neural Network Compression For Citizen-Driven Tick And Mosquito Surveillance, Yichao Liu, Emmanuel Dufourq, Peter Fransson, Joacim Rocklöv

Faculty Publications

Citizen science has emerged as an effective approach for infectious disease surveillance. With advancements in machine learning, entomologists can now be relieved from the labor-intensive task of species identification. However, deploying machine learning models on mobile devices presents challenges due to constraints on battery life and memory capacity. In this study, we explore the potential of various model compression techniques for deploying machine learning models on resource-limited devices, enabling low-energy consumption and on-device processing for disease surveillance in remote or low-resource settings. We compared two main-stream model compression techniques, pruning and quantization on various mobile devices. Our findings indicate that …

From Awareness To Integration: Leading The Change For Occupational Therapy, Shirley A. Wells

Occupational Therapy Faculty Publications

In her lecture for the inaugural Dr. Lela A. Llorens Award of Excellence for Diversity, Equity, and Inclusion, Dr. Shirley A. Wells acknowledges the growing importance of creating more inclusive and equitable environments across all aspects of health care, with occupational therapy being no exception. Inclusion and integration are fundamental values that should be woven into every part of the practice of occupational therapy. It is not enough to be aware of these concepts; occupational therapists must actively engage in Acts of Inclusion and Integration in their delivery of care, collaboration with clients and colleagues, and shaping of the future …

A Deep Dive Into The Nazis’ Animal World: Facilitating The Holocaust Through Symbolization, Filippa V. Frogner

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper examines the use of animal symbolism in Nazi propaganda as a tool to dehumanize Jewish individuals and facilitate the Holocaust. Through an analysis of propaganda posters, films, and literature, it highlights how Jews were consistently depicted as animals such as rats, cockroaches, and monkeys—symbols associated with filth, disease, and inferiority. These portrayals, often reinforced by explicit textual messages, stripped Jews of their humanity and encouraged widespread acceptance of their persecution and extermination.

By exploring the methods, extent, and consequences of this dehumanizing propaganda, the paper sheds light on the critical role of animal symbolism in shaping public perception …

Approved Courses 10-7-25, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Icc Agenda 10-7-25, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Ucc Minutes 10-7-25, Angela Brock

UCC Agendas/Minutes

No abstract provided.

In Pursuit Of The Optimal Antimicrobial Stewardship Practice Model: A Multihospital Analysis Of Direct Patient Care Interventions To Characterize The Role Of Infectious Diseases Pharmacists, Jefferson Cua, Alice Landayan, Lourdes Menendez Alvarado, Lee Amaya, Timothy Gauthier

All Publications

This retrospective analysis across 3 hospitals evaluates antimicrobial stewardship interventions by clinical pharmacists, specialist pharmacists, and infectious diseases specialist pharmacists. Findings highlight differences in intervention types, urgency, and complexity, underscoring the value of infectious diseases specialist pharmacists in optimizing patient care and antimicrobial use within a multitiered pharmacy practice model.

Animal-Centered Service Design For Stray Animals In India, Faiza Khan, Shamit Shrivastav

ServDes Conference Series

According to the State of Pet Homelessness Index data of 2021, India has a high prevalence of stray animals, with around 80 million homeless cats and dogs. The living conditions of these animals are harsh and unsafe. Services for stray animals are managed by the animal welfare departments, non-profit organizations, and caretakers. The objective of this study is to investigate the efficacy of existing stray animal welfare services and understand the role of the stakeholders towards creating a safe and healthy environment for these animals. Semi-structured interviews of eighteen stakeholders and site immersions at five Mumbai-based NGOs were conducted. The …

Infective Endocarditis And Meningitis In A Healthy Newborn Without Underlying Heart Disease, Due To Streptococcus Agalactiae - A Case Report., Dalal Siddig Idris, Muath Mohammed Al Ghamdi, Maria Laura Bellovalls, Mohammed Fararjeh

Journal of the Saudi Heart Association

Streptococcus Agalactiae endocarditis is a rare clinical entity in newborns with a normal structured heart. It is generally characterized by acute onset, the presence of large vegetations, rapid valvular destruction and frequent complications, particularly embolization. Mortality is high with medical therapy alone. We are reporting a rare case of infective endocarditis (IE) with mitral valve vegetation in a 9-day old healthy newborn following Streptococcus Agalactiae sepsis, complicated by meningitis and micro-abscesses. Mitral valve (MV) vegetation was removed surgically; the patient received intravenous antibiotics for six weeks. Transthoracic echocardiography after surgery showed severe MV regurgitation and severe pulmonary hypertension which was …

Practicing With Intent: How To Teach An Old Dogma New Tricks, Matthew C Phillips, Kusha Davar, Sarah Freling, Steven Y C Tong, Todd C Lee, Emily G Mcdonald, Travis B Nielsen, Noah Wald-Dickler, Alfredo J Mena Lora, Rachael A Lee, Fergus Hamilton, Daniel M Musher, Rodrigo P L Costa, Bassam Ghanem, Rachel Baden, Brad Spellberg

Faculty, Staff and Students Publications

Clinicians are constantly bombarded with an onslaught of newly published data, yet they must make clinical decisions despite a dearth of clinical data. Sometimes, they may fall back on clinical practices entrenched by experience, unaware that they are upheld by dogmatic tradition rather than robust evidence. Ideally, the totality of evidence must be assessed and utilized for clinical decision-making, irrespective of entrenched orthodoxy. Here, we explore the questions, how much evidence is needed to revise established clinical practices and, more fundamentally, can data alone truly catalyze such shifts.

Correlation Of Immunological Biomarkers And Severity Of Pneumonia In Pediatric Patients, Dhifaf Abdulrhaman, Mohammed B Hassan

Al-Nisour Journal for Medical Sciences

Among children under five, pneumonia stands as a major contributor to both illness and death, creating a significant challenge for global health efforts. This study aimed to evaluate the correlation between radiological severity, clinical parameters (such as fever and oxygen saturation), and laboratory markers (including CRP levels, white blood cell count, and the neutrophil-to-lymphocyte ratio) in pediatric patients with pneumonia. A retrospective analysis was conducted on 51 hospitalized children with severe pneumonia admitted to Al Mansour Pediatric Hospital in Baghdad from July 2024 to February 2025. The results revealed a strong association between radiologic severity and clinical indicators, with higher …

The Importance Of Pus/ Epithelial Cells Counts In Diagnosis Of Urinary Tract Infection And Asymptomatic Bacteriuria., Saja Hadi Abdul . Hamza, Suhad Hadi Mohammed

Al-Ameed Journal for Medical Research and Health Sciences

Background: Asymptomatic bacteriuria (ABU) is often diagnosed incidentally, and detection of bacteria in urine can lead to unnecessary antibiotic use, may aggravate antimicrobial resistance. To our knowledge, no prior study has focused on the dual presence of pus and epithelial cells (PEDP) and its diagnostic value.

Objective: To evaluate the importance of Pus/ Epithelial Cells Counts in diagnosis of ABU and UTI.

Methods: A case-control study was conducted on (140) females, divided into two groups: 70 with UTI and 70 apparently healthy controls, 28 had ABU and 42 had sterile urine cultures, with age ranging from (18 to over 58) …