Digital Commons Network^™

Implementing A Cardiac Catheterization Pre-Procedure Protocol To Decrease Avoidable Same-Day Cancellations, Christina C. Perry

Doctor of Nursing Practice

Background and significance of the problem: Pediatric congenital heart defect patients are amongst the sickest hospital population. These patients require planned palliation in the cardiac catheterization lab (cath lab), which has a limited number of providers and appointments available. In the cath lab, the percentage of avoidable same-day cancellations for interventional procedures was found to be greater than 30%, representing significant resource utilization opportunities.

Purpose: The purpose of this project was to develop and implement a standardized, evidence-based pre-procedure protocol to decrease avoidable same-day cath lab cancellations.

Goals and objectives: The goals of this project were a 10% decrease in …

Exploring Online Teaching Self-Efficacy Among University Faculty Members During The Period Of Covid-19 Pandemic, Sarah Alamri

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study is to examine faculty’s perceptions of their self-efficacy regarding online teaching and some variables that may affect online teaching efficacy. A quantitative survey was administered to examine whether three faculty variables (online teaching experience, professional development experience, and COVID-19) predict a significant portion of the variance in faculty self-efficacy in online teaching on four subscales: student engagement, instructional strategies, classroom management, and teachers’ computer use. Faculty participants were recruited from King Khalid University in the Kingdom of Saudi Arabia. Data were collected using a web-based survey adapted from Robinia (2008). The data collected in this …

Integrated Perspectives: Florida Ems Workforce And Agency Synthesis 2025, Michael Lozano

Florida Center for Emergency Medical Services Research Reports

The Florida Center for Emergency Medical Services (FL-CEMS) integrated findings from the 2024 EMT and Paramedic Renewal Survey (49,200 clinicians), the 2025 EMS Provider Survey (260 agencies), and 2024 NREMT Cognitive & Certification exam outcomes to provide a comprehensive picture of Florida’s EMS workforce and training environment.

“I Was The Only One Who Was Alone:” The Impacts Of Covid-19 Pandemic On International Students In U.S. Higher Education, Lawrence Ejiofo

All-Inclusive List of Electronic Theses and Dissertations

This research examined the impact of the COVID-19 pandemic on international students. The study focused on their academic, racial, emotional, psychological stress and trauma experiences. The student participants interpreted these experiences through their lens and backgrounds as international students. They expressed the feelings of desertion and abandonment during the pandemic. The findings showed that the impacts sustained and endured by international students during the COVID-19 pandemic were real, painful, disturbing, and emotional. The image created of the US and other first world countries in the 21st century was very damaging and showed failure of leadership management. It had been more …

Reclaiming Bodily Autonomy Through Gullah Geechee Natural Healing, Tamaray Yvonne White

Electronic Theses and Dissertations

In today’s sociopolitical climate, restrictive reproductive laws continue to disproportionately target Black women, reinforcing historic patterns of racialized and gendered oppression. This thesis argues that Black women will recommence their usage of traditional herbal healing as both a survival strategy and an act of reclaiming bodily autonomy in defiance of hostile legal, financial, and medical systems. The Gullah Geechee community serves as a blueprint for this transition, offering cultural continuity, intergenerational knowledge, and a model for community-based healthcare and resistance. By tracing the historical necessity of herbal medicine among Gullah Geechee women, this study situates ancestral natural healing within contemporary …

Impact Of Antibody Fc Engineering On Translational Pharmacology, And Safety: Insights From Industry Case Studies., Frank R Brennan, J Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Tilman Schlothauer, Shirley J Peters, Curtis C Maier, Changhua Ji, David L Wensel, Derrick Witcher, Patricia C Ryan, T Scott Manetz, Adriano Flora, Brian Soper, Birgit Fogal, Lindsey Dzielak, Xiaoting Wang, Prathap Nagaraja Shastri, Karen Price, Michael Doyle, Nidhi Sharda, Mary Struthers, Maximilian Brinkhaus, Bianca Balbino, Eric Stefanich, Masaki Honda, Jan Terje Andersen, Shermaine Mitchell-Ryan, David P Humphreys

Faculty Research 2025

Therapeutic monoclonal antibodies (mAbs) are often designed to not only bind targets via their antigen-binding domains (Fabs) but to also engage with cell surface receptors, FcγRs and FcRn, through their Fc regions, which may result in a variety of functional outcomes, including antibody- dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) and alteration of circulating half-lives. Engineering the Fc regions to achieve desirable pharmacology and pharmacokinetics is a widely adopted strategy in drug development. Fc regions can be modified through amino acid substitutions and glycoengineering, resulting in enhanced or reduced effector functions, preferential binding to FcR subtypes, …

Diagnostic Accuracy Of Nanopore Sequencing For Detecting Mycobacterium Tuberculosis And Drug-Resistant Strains: A Systematic Review And Meta-Analysis, Timothy Hudson David Culasino Carandang, Dianne Jaula Cunanan, Gail S. Co, John David Pilapil, Juan Ignacio Garcia, Blanca I. Restrepo, Marcel Yotebieng, Jordi B. Torrelles, Kin Israel Notarte

Ateneo School of Medicine and Public Health Publications

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) infection, remains a significant public health threat. The timeliness, portability, and capacity of nanopore sequencing for diagnostics can aid in early detection and drug susceptibility testing (DST), which is crucial for effective TB control. This study synthesized current evidence on the diagnostic accuracy of the nanopore sequencing technology in detecting MTB and its DST profile. A comprehensive literature search in PubMed, Scopus, MEDLINE, Cochrane, EMBASE, Web of Science, AIM, IMEMR, IMSEAR, LILACS, WPRO, HERDIN Plus, MedRxiv, and BioRxiv was performed. Quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Pooled …

The Disaster Management Complex: Law’S Adaptations In Times Of Climate Disaster, Michael Burger, Jeffrey Schlegelmilch, Lucia Bragg

Sabin Center for Climate Change Law

The Anthropocene is marked by constant climate-related disasters and defined by the urgent need to foster and implement adaptations to future climate impacts that reduce disaster risk. The intensity, frequency, and severity of extreme weather events continue to rise even as nations and corporations alike miss their emissions targets, all promising a hotter, wetter, and more extreme future. A number of federal agencies, including the Federal Emergency Management Agency (FEMA), have, at times, sought to adapt their own famously fragmented responses to these changing circumstances. However, federal disaster response is conducted against a backdrop of authorizing legislation that is designed …

How Fundraisers Met Goals During The Covid-19 Pandemic, Cody C. Greene

Electronic Theses and Dissertations

The COVID-19 pandemic disrupted nearly every aspect of higher education operations, including fundraising and donor engagement. This qualitative study explored how Vice Presidents for Advancement and other senior fundraising leaders in higher education adapted their practices to meet fundraising goals during the pandemic. Using a narrative design, in-depth interviews were conducted with nine participants representing diverse institutions in the southeastern United States. Braun and Clarke’s (2006) six-phase thematic analysis was used to code and interpret the data.

Seven major themes emerged: communications, technology, donor relations, managing a fundraising team, overall giving impact, successful strategies, and the future. Participants described how …

Next-Generation Terrorism: Understanding Agentic Ai Systems And Potential For Malign Use, Alexis D'Amato, Ares Boira-Lopez, Emma Theobald, Meg Shercliffe, Jack Rygg, Samuel Hunter, Joel Elson

Reports, Projects, and Research

The call for an increased understanding of artificial intelligence in the U.S. AI Action Plan (The White House, 2025), in tandem with the growing use of AI by terrorist organizations (see Theobald et al., 2025), motivates our effort to provide clarity around the emerging technologies. In doing so, we define and distinguish the features of agentic AI and provide several case studies to illustrate the nefarious use of these tools. Although the current base rate for this type of use is low, we forecast hypothetical use cases given previous examples of terrorists adopting technology and outline the malign use of …

Effects Of Exercise Timing On Circadian Rhythm And Functional Outcomes In Cancer Patients Undergoing Treatment, Buck Williams Covington Ii

Dissertations

Poor sleep quality and circadian rhythm disruption are commonly reported among cancer survivors and may contribute to worsened health outcomes, including increased fatigue, psychological distress, and reduced quality of life. While some recent studies suggest that exercise can improve sleep and circadian regulation in cancer survivors, limited research exists on how the timing of this exercise affects these outcomes in cancer survivors. The purpose of this study was to examine the effects of a 12-week supervised exercise intervention, performed either in the morning (AX) or evening (PX), on functional capacity, subjective and objective sleep quality, and peripheral markers of circadian …

Evaluating The Effectiveness Of An Air Purification System In Reducing Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens, Abdulaziz Ali Alqahtani

Graduate Theses and Dissertations

Bacterial chondronecrosis with osteomyelitis (BCO) is the primary cause of lameness in commercial broiler production and has a profound impact on animal welfare and cost-effectiveness. The purpose of this experiment was to examine the effect of an air purification system on mitigating BCO lameness in broiler chickens. One thousand eight hundred broiler chicks were reared in two side-by-side research barns. Eight air filtration units were installed in one building, and none in the other. Treatment groups in both houses included positive control birds on wire flooring to induce BCO, as well as negative control, feed additive, vaccination, and a combination …

Adsorption-Based Electrochemical Assay For Nucleic Acid Detection On 2d Nanomaterials, Prabhangshu Kumer Das

Dissertations

Electrochemical biosensing based on the adsorption of nucleic acids onto two-dimensional (2D) nanomaterials offers distinct advantages over conventional techniques, including enhanced sensitivity, selectivity, and simplified probe immobilization. Significant efforts have been directed toward developing sensing platforms that exploit the high surface area and unique physicochemical properties of materials such as graphene oxide (GO) and molybdenum disulfide (MoS₂) to achieve efficient signal transduction. This adsorption-based approach eliminates the need for complex surface modifications or labeling, as nucleic acids interact with 2D surfaces through π–π stacking, van der Waals forces, hydrogen bonding, electrostatic interactions, and ion bridging.The efficiency of nucleic acid immobilization …

Using Color And Fluorescent Spectrometry As A New Rapid Cleaning Verification Method In Poultry Processing Plants, Clark Griscom

Graduate Theses and Dissertations

The poultry industry is expected to be growing at 3% in the total global market with the U.S. being the largest producer of poultry meat. Poultry processing plants are expected to produce 140 birds per minute with the potential of up to 175 birds per minute to meet the market demand. With the growing market and need for faster production, maintaining food safety needs to be a priority to ensure the safety of consumers. Over 9.9 million foodborne illness cases are reported each year in the United States. A change in food safety is needed, and one area lacking is …

Next-Generation Salmonella Inactivated Vaccine Platforms And Phytobiotic-Modulated Immune Responses In Poultry, Santiago Uribe Diaz

Graduate Theses and Dissertations

Here, a comprehensive understanding of immune responses triggered by either a multimeric CD40 receptor-agonistic DNA aptamer-based or mannosylated chitosan-based Salmonella Enteritidis inactivated vaccine platforms, along with phytobiotic supplementation as an immune modulatory strategy in response to Salmonella lipopolysaccharides, is presented. This dissertation supports the development of next-generation Salmonella vaccine platforms that simultaneously stimulate both protective cell-mediated and humoral immune responses, while indicating the potential immunomodulatory effects of phytobiotics supplementation to reduce the immunological impact of Salmonella lipopolysaccharides in chickens. The first chapter describes that both vaccine platforms administered in broiler chickens initiated local inflammatory responses, recruiting heterophils and macrophages from …

Large-Scale Experimental Study On The Impact Of Air Cleaning & Ventilation On Indoor Air Quality And Student Illness-Related Absenteeism, Daud Nosham

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This large-scale randomized experimental field study investigated the effect of portable air purifiers (PAPs) on classroom’s air quality and student’s illness related absenteeism. PAPs were installed in 317 classrooms from various school districts located in Eastern Nebraska. The classrooms were randomly assigned into four conditions: three treatment conditions (T1, T2 & T3) and one control condition (device without any filter). T1 was equipped with HEPA filters, T2 added Activated Carbon (AC) layer to HEPA, and T3 further integrated Germicidal Ultraviolet (GUV) alongside HEPA and AC filters. The measured variables were carbon dioxide (CO2), fine particles (PN2.5) and coarse particles (PNcoarse), …

Factors Associated With Preterm Premature Rupture Of Membranes: A Case-Control Study In A Tertiary Hospital In Kabul, Afghanistan, Atia Sharif Nadi, Freshta Sharif Tawakkuli, Zainab Sharif Ezadi, Sayed Murtaza Sadat Hofiani, Shoaib Murtaza Sadat Naeemi, Ahmad Komail Frogh

Journal of Asian Midwives (JAM)

Background: It is essential to identify preterm premature rupture of membranes (PPROM) and its associated risk factors to reduce its impact. This study aims to find the demographic, reproductive, and obstetric factors associated with PPROM among women in Kabul, Afghanistan.
Methods: This case-control study was conducted over six months in 2023 at a tertiary hospital in Kabul, Afghanistan. We included 40 cases of PPROM and 80 controls without PPROM in this study. We used structured questionnaires to collect demographic, reproductive, and obstetric characteristics of the participants. To find the factors associated with PPROM, Logistic regression was performed using IBM SPSS …

A Scoping Review Of Maternal Active Smoking During Pregnancy And Low-Birth Weight, Naomi Sondang, Nindi Oktavia, Qorinah Estiningtyas Sakilah Adnani, Lani Gumilang, Hadi Susiarno, Victor Abiola Adepoju

Journal of Asian Midwives (JAM)

Background: Low-birth weight (LBW; < 2.5 kg) infants are at increased risk of early mortality, impaired growth, neuro-developmental delay and chronic disease later in life. Maternal behavior, especially cigarette smoking, remains one of the most modifiable determinants of birth weight. We therefore synthesized recent evidence on the association between active maternal smoking during pregnancy and LBW.
Methods: Following PRISMA guidance, we systematically searched PubMed, Scopus and ScienceDirect for the period January 2020 to 31 January 2025 for English-language observational studies that quantified the relationship between active prenatal smoking and LBW. Risk of bias was appraised, and findings were summarized narratively.
Results: In total 26,650 papers were found and eight eligible studies (four cohort, three cross-sectional, one case-control) from Asia, Europe and the Middle East were included. Across all designs and exposure metrics—self-report, exhaled carbon-monoxide, urinary cotinine, and cord-blood DNA-methylation, active smoking was consistently associated with …

Prevalence And Characterization Of Post-Acute Sequelae Of Sars-Cov-2 Infection (Pasc) In Rwanda, Fernand Rwamwejo, Vivianne Umuhire Niyonkuru, Gilbert Rukundo, Eric Remera, Edson Rwagasore, Les Sztandera, Ruranga Charles, Elizabeth Krebs

School of Business Faculty Papers

Objectives

Reliable, population-level estimates of post-acute sequelae of SARS-CoV-2 infection (PASC) remain scarce for sub-Saharan Africa. We aimed to quantify PASC prevalence and identify associated factors among adult COVID-19 survivors in Rwanda.

Methods

A nationally representative cross-sectional telephone survey (August-October 2024) sampled 3143 adults from the national COVID-19 registry. PASC was defined as new or persisting symptoms ≥3 months after acute illness and lasting ≥2 months. The prevalence was calculated, and multivariable logistic regression identified factors independently associated with PASC.

Results

Overall, PASC prevalence was 34%. Leading symptoms were back pain, headache, dizziness, fatigue, and reduced sexual desire. Higher odds …

Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI), contributing to 5-13% of cases worldwide. Clinical manifestations vary by HAdV species and type; therefore, delineating type-specific disease presentations and understanding severity of specific HAdV types' disease may help develop targeted interventions.

METHODS: We conducted a multicenter, prospective study within the New Vaccine Surveillance Network to characterize HAdV types. Children < 18 years old with ARI were enrolled in the emergency department or inpatient setting at 7 US children's hospitals from 1 December 2016 to 30 November 2019. Respiratory specimens were collected and tested for HAdV and other viruses. Subsequently, typing was conducted on HAdV specimens using single-plex real-time PCR assays targeting sequences in the hexon gene. Comparisons between HAdV types were performed to determine differences in characteristics and outcomes. Generalized linear mixed effects models were used to evaluate severity.

RESULTS: Among the 1843 HAdV-positive cases, 1402 specimens (76%) were typed. The most common types detected were HAdV-C1 (n = 439), HAdV-C2 (n = 393), and HAdV-B3 (n = 221). Children with HAdV-B7 (n = 78) …

Clinical Long-Read Sequencing Test For Genetic Disease Diagnosis., Isabelle Thiffault, Emily G. Farrow, Cassandra Barrett, Meadow Scott, Amy Ross, John C. Means, Warren A. Cheung, Adam F. Johnson, Boryana Koseva, Rebecca Mclennan, Elin Grundberg, Chengpeng Bi, Carl F. Schreck, Byunggil Yoo, Jeffrey J. Johnston, Florencia Del Viso, Vitoria Paolillo, John Herriges, Lei Zhang, Margaret Gibson, Ana S A Cohen, Joseph Alaimo, Carol J. Saunders, Tomi Pastinen

Manuscripts, Articles, Book Chapters and Other Papers

This diagnostic study examines the diagnostic yield and turnaround time of long-read sequencing compared to standard-of-care approaches.

Aku Research 2025, Office Of Research And Graduate Studies

Office of Research and Graduate Studies

• With dementia surging, BMI seeks tools for prevention
• The past, present and future of teaching in Pakistan
• Transforming educations with evidence
• Research influences national teacher development programme
• Redefining the migrant experience
• Study finds women are underrepresented in East Africa’s media
• Study identifies targets for treating drug-resistant tuberculosis
• Addressing extreme heat’s impacts on the vulnerable
• Colorectal cancer detection gets an AI boost
• Addressing the quiet crisis of women’s mental health
• The pandemic was especially hard for female health workers
• Advancing reproductive health in Pakistan
• A push for advanced practice nursing and midwifery
• Major study yields essential data on maternal health
• Saving …

A Comparison Of Cultural Aspects Of Breastfeeding In The United States Vs Italy, Madison P. Wallace

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Healthcare systems internationally differ from policies, funding and resources available, and it is evident when comparing the United States and Italy. Participation in the Nursing Across the Lifespan study abroad program at the University of Arkansas Rome Center and Tiny Tusk Breastfeeding and Infant Support internship inspired a comparative exploration of breastfeeding practices in the United States versus. Italy. The United States has a mixed public- private insurance system, workplace policies and government assistance, while Italy has a universal healthcare system with a mandated maternal work paid leave to support breastfeeding mothers. Italy's program supports education and physical care needed …

Understanding Hepatitis C Risk And Harm Reduction Needs Among People Who Smoke Drugs: A Client-Centered Qualitative Inquiry, Maxwell Gustin

Anthropology

The spread of Hepatitis C virus (HCV) via non-injectable equipment is plausible, making people who smoke drugs (PWSD) at-risk for possible infection and transmission. While much research has been conducted into injection drug use (IDU), likely due to the rising opioid epidemic, limited studies focus on the risks PWSD face. Currently, state-funded syringe service programs (SSPs) provide harm reduction education and materials to combat these risks. Safer smoking initiatives have been created and are widely used by PWSD, and have access to SSPs. To gain better insight into the HCV and non-HCV-related risks and burdens PWSD face, a qualitative study …

Implications Of The Attenuated Allee Effect On Population Dynamics, Dana Strong

All Graduate Theses and Dissertations, Fall 2023 to Present

The Allee effect is an ecological phenomenon characterized by a per capita growth rate that increases as the population size increases in the context of low population density. The Allee effect can lead to rapid extinction events. Consequently, ecologists can attempt to control the strength of the Allee effect to help increase the population (in the case of endangered species) or decrease the population (in the case of parasites or pests).

This research aimed to study not the strength of the Allee effect, but the intensity of the Allee effect, or how rapidly cooperation between individuals causes the per capita …

Identifying Barriers For Community Pharmacies As Vaccines For Children (Vfc) Providers In Rural Alabama: Opportunities For Solutions, Myra Bajwa

Honors Theses

Significant Human papillomavirus (HPV) vaccination disparities exist between rural and urban areas in the US. A primary contributor is low access to preventive care in rural areas. Among the most promising strategies to overcome this is increasing access through offering HPV vaccination in non-traditional, convenient health settings such as pharmacies. In rural areas, community pharmacies are trusted, convenient pillars of the community. In Alabama, community pharmacies are eligible for enrollment in the Vaccines for Children (VFC) Program, a federally-funded program that provides free vaccines to children and adolescents under 18 years old who are uninsured, underinsured, American Indian, or Alaska …

The Genetic And Environmental Determinants Of Stress Resilience Across Model Systems, Carson Len Stacy

Graduate Theses and Dissertations

Survival in fluctuating environments demands that organisms effectively anticipate and respond to future challenges. This capacity is shaped by both genetic background and environmental context. In this dissertation, I apply a population aware lens to explore how genetic diversity and environmental conditions intersect to shape stress survival. Integrating functional genomics and transcriptomics in Saccharomyces cerevisiae (brewer’s yeast) and a vertebrate (common canary) system, I dissect gene-by-environment (GE) interactions that underpin resilience. First, I move beyond a single reference genome by using a pan-genomic CRISPR knockout screen to assess osmotic stress survival across diverse S. cerevisiae isolates. This analysis reveals a …

Impact Of Intravenous Drug Use On Neck Abscess Outcomes: 30-Day Readmission & 5-Year Survival Rates, Elliott Sina, Bryce Hambach, Eric Mastrolonardo, Sruti Tekumalla, Meghan Crippen, Richard A. Goldman

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVES: Injection drug use (IDU) is a known risk factor for neck abscesses, often requiring urgent surgical intervention by acute-care Otolaryngologists. However, data on the prevalence and long-term outcomes of IDU-related neck abscesses are limited. This study investigates differences in 30-day readmission rates and 5-year all-cause mortality between patients with and without a history of IDU hospitalized for neck abscesses.

METHODS: This is a retrospective cohort study utilizing the TriNetX national clinical database. Patients hospitalized for neck abscesses (ICD-10: L02.11) were categorized into two cohorts: IDU (current/previous) and non-IDU. Demographics, 30-day readmission rates, and 5-year survival were analyzed. 1:1 Propensity …

Combating Antimicrobial Resistance In Asia: A Comprehensive Review Of Strategic Action Plans, Policies, And The Role Of The Who, Saud Almawash

Saudi Medical Journal

ABSTRACT Over the past 70 years, antimicrobial resistance (AMR) has emerged as a critical public health concern in Asia. Regional challenges such as dense population, scarce resources, and diverse healthcare systems further complicate the containment efforts. To address this, Asian countries have adopted several strategies and policies. A comprehensive review of published literature was conducted to identify key policies and interventions. Findings revealed diverse approaches to AMR containment, including surveillance and monitoring systems, antibiotic stewardship programs, infection control measures, vaccination strategies, and public health awareness campaigns. However, implementation of these strategies is hindered by resource, political, and regulatory barriers. The …

Asymptomatic Cryptococcal Antigenemia: A Multi-Clinic Cross-Sectional Study On The Prevalence, Associated Factors And Predictors Of Three-Month Outcomes Among Antiretroviralnaïve And Antiretroviral-Experienced Hiv Patients In Dar Es Salaam, Tanzania, Mandela Makakala, Mukasa Mohammed, Mabula Mabelele, Kamran Hameed, Philip Adebayo

Internal Medicine, East Africa

Background: Cryptococcal meningitis remains a leading cause of HIV/AIDS-related mortality, predominantly in Sub-Saharan Africa. Current screening and prevention efforts primarily target antiretroviral therapy (ART)-naïve patients, whereas strategies for ART-experienced individuals are less well defined.

Objectives: This study primarily aimed at determining the prevalence of asymptomatic cryptococcal antigenemia (ACA) among ART-naïve and ART-experienced patients, along with associated factors and predictors of three-month outcomes among HIV patients in three HIV clinics in Dar es Salaam, Tanzania. Secondarily, factors associated with serum cryptococcal antigen positivity in the overall study population were also assessed.

Methods: This cross-sectional clinic-based study recruited 273 HIV-positive participants (ART-naïve …