Digital Commons Network^™

Guide For Selecting Experimental Models To Study Dietary Fat Absorption, Andromeda M. Nauli, Ann Phan, Karen Mai, Kathleen Tran, Surya M. Nauli

Pharmacy Faculty Articles and Research

Dietary fat absorption is a complex, multi-step process involving digestion, enterocyte uptake, intracellular trafficking, re-esterification, and transport via lipoproteins into circulation. Because dietary fat absorption plays a central role in lipid homeostasis, metabolic syndrome, and fat malabsorption disorders, its study has a broad biomedical significance. However, experimental investigation of this process is technically challenging due to the short lifespan of enterocytes, the dual lymphatic and portal transport routes, and the need to trace the metabolic fate of absorbed lipids. This review summarizes and critically evaluates the major experimental systems used to study dietary fat absorption, highlighting their respective strengths, limitations, …

High Phosphorus Intake: The Role Of Phosphorus And Health Outcomes Through The Lens Of High Phosphorus Additive Intake, Taigen M. Mayes

Senior Honors Theses

Phosphorus is a commonly consumed mineral in the traditional human diet and plays an essential role in human physiological functions. With the use of phosphate additives, high phosphate intake has become increasingly prevalent in recent years. Phosphate is regulated in the body by a homeostasis mechanism. A disruption to the homeostasis has a link to various pathologies such as bone health, cardiovascular disease, cancers, and kidney issues. Various studies have investigated the role of phosphate and its effects on human function. Bone health, cardiovascular disease, cancer, premature aging, dementia, and kidney disease are linked with high phosphorus intake.

Cover And Front Matter

Research and Reflection on Learning and Teaching in Higher Education

Cover and Table of Contents for Volume 3 (2025)

Heat And Kidney Health: Exploring The Impact Of Rising Temperatures On Kidney Health And Vulnerable Populations, Hoimonty Mazumder

Electronic Theses and Dissertations Archive

This dissertation examines how ambient temperature influences renal health across three complementary chapters by exploring: sex-stratified temperature-urine biomarkers relationships, a global comprehensive synthesis of evidence on renal colic, and mediation effect of BP in the biological pathway between ambient temperature and proteinuria. We used repeated measurements of urinary electrolytes, 24-h urine total protein (UTP), and volume as outcomes from a stepped-wedge RCT conducted in southwest coastal Bangladesh and collected daily ambient temperature data from Bangladesh Meteorological Board (BMD). We employed piece-wise linear mixed effect models using random intercepts to demonstrate ambient temperature and urine biomarker’s relationships. We summarized global evidence …

Hydration Strategies In Ultra-Endurance Running: A Narrative Review Of Programmed Versus Thirst-Driven Approaches, Shawn C. Wierick, Rosie I. Perez, Xiujing Zhao, Brendon P. Mcdermott

Health, Human Performance and Recreation Faculty Publications and Presentations

Background/Objectives: Ultra-endurance running (UER) presents unique hydration challenges due to prolonged duration, variable terrain, environmental extremes, and gastrointestinal limitations. Athletes often use either programmed fluid intake (PFI), which prescribes fluid volumes based on estimated sweat rate, or thirst-driven fluid intake (TDFI), which relies on internal cues. This review examines the effectiveness and limitations of each strategy in the context of UER performance and safety. Methods: A narrative review was conducted using a targeted selection of peer-reviewed studies. Both laboratory- and field-based research were included to evaluate the physiological rationale, practical feasibility, and outcomes associated with PFI and TDFI. A total …

Developing A High-Throughput Machine Learning Screening Platform For Genetic And Pharmacological Modulators On Caenorhabditis Elegans Seizure Behavior, Paul A. Scarpinato

Electronic Theses and Dissertations 2020 - Present

Epilepsy is a chronic neurological disorder characterized by recurrent seizures that affect over 50 million people worldwide, including more than 3.5 million in the United States. Seizures arise from a disrupted balance between excitation and inhibition. Although antiepileptic drugs (AEDs) remain the primary treatment to restore the excitation and inhibition balance, approximately 30% of patients experience drug-resistant epilepsy, highlighting the need for additional antiseizure medications. The Caenorhabditis elegans electroshock assay was developed in relative alignment with the rodent maximal electroshock seizure (MES) test, the gold standard for preclinical AED screening, provides a cost-effective platform for prescreening candidate AEDs.

This work …

Roux-En-Y Gastric Bypass Is Associated With Increased Intestinal Glucose Uptake In Humans, Florina Corpodean, Maryam Naseri, Michael Kachmar, Julia St Amant, Denis P. Blondin, Owen T. Carmichael, Vance L. Albaugh

School of Medicine Faculty Publications

CONTEXT: In animal models, Roux-en-Y gastric bypass (RYGB) is associated with increased Roux limb intestinal glucose uptake that may contribute to early metabolic benefits, though prospective clinical studies are lacking. OBJECTIVE: The present study aimed to test the hypothesis that Roux limb glucose uptake would increase relative to baseline in a cohort of patients undergoing RYGB. METHODS: RYGB patients underwent preoperative baseline, and 3- and 6-month positron emission tomography/computed tomography postoperative imaging. Maximum and mean standardized uptake values (SUV) were measured from the following predefined regions of interest: cecum, hepatic flexure, splenic flexure, sigmoid colon, duodenal bulb, Roux limb, and …

Salvadora Persica’S Effects On Oral Microbiota And Possible Pathophysiological Links To Type Ii Diabetes Mellitus Risk Factors, Ahmed Bahieldin, Heba J. Sabbagh, Mohammed H Alshehri, Abdullah M. Algarni, Naif Aljahdali, Ibrahim M. Asir, Khalid Mohammed Alzahrani, Awad S. Almhwary, Fatemah Saleh Alzaghabi, Abdullah Jaber Alsahafi, Amjed S Alshehri, Ali Ahmed Alzahrani, Faisal M. Alotaibi, Mohammed A. Alghamdi, Abdulwahab S. Almutairi, Sherif Edris

The Journal of King Abdulaziz University: Science

The application of Miswak (Salvadora persica) in healthy children was investigated to identify the oral microbiota associated with risk factors for type II diabetes mellitus (T2DM). Deep sequencing of the bacterial 16S rDNA V3–V4 regions was conducted on oral microbiome samples obtained prior to and following swaking. The KEGG database and PICRUSt analysis indicated that swaking affected functional pathways, resulting in an enrichment of transport pathways and a decrease in the risk factor associated with the T2DM pathway. Seven operational taxonomic units (OTUs), comprising the uncharacterized species Prevotella, Atopobium, Actinomyces, Lactobacillus, Neisseria bacilliformis, Actinomycetaceae, …

Bilateral Hypoglossal Nerve Stimulation For Obstructive Sleep Apnea: A Nonrandomized Clinical Trial, B. Tucker Woodson, David T. Kent, Colin Huntley, Melyssa K Hancock, Douglas J. Van Daele, Maurits S. Boon, Tod C. Huntley, Sam Mickelson, M. Boyd Gillespie, Maria V. Suurna, Ashutosh Kacker, Asim Roy, Stuart Mackay, Kirk P. Withrow, Raj C. Dedhia, Phillip Huyett, Clemens Heiser, Sylvie Di Nicola, Fatima Makori, Olivier M. Vanderveken, Tapan A. Padyha, Ulysses J. Magalang, Eugene Chio, Eric J. Kezirian, Richard Lewis

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Study Objectives: To evaluate the safety and efficacy of a novel bilateral hypoglossal nerve stimulation (HNS_BL) device for the treatment of obstructive sleep apnea.

Methods: Adult patients with moderate-to-severe obstructive sleep apnea who refused, failed, or did not tolerate positive airway pressure therapy underwent implantation and nightly use of HNS_BL. The coprimary endpoints at 12 months were (1) a minimum of 50% reduction in the 4% apnea-hypopnea index (AHI) from baseline with a final AHI of less than 20 events/h, and (2) a minimum of 25% reduction in the 4% oxygen desaturation index. Objective secondary endpoints …

Mechanisms Matter, Nicole L. Collins, Kenneth S. Campbell

Physiology Faculty Publications

No abstract provided.

Six Drivers Of Aging Identified Among Genes Differentially Expressed With Age, Ariella Coler-Reilly, Zachary Pincus, Erica L Scheller, Roberto Civitelli

2020-Current year OA Pubs

Many studies have compared gene expression in young and old samples to gain insights on aging, the primary risk factor for most chronic diseases. However, these studies only identify associations without distinguishing drivers of aging from compensatory geroprotective responses or incidental downstream effects. Here, we introduce a workflow to characterize causal effects of differentially expressed genes on lifespan. First, we performed a meta-analysis of 25 gene expression datasets comprising samples of various tissues from healthy, untreated adult mammals (humans, dogs, and rodents) at two distinct ages. Genes were ranked by the number of datasets in which they exhibited consistent differential …

The Role Of Psilocybin In End-Of-Life Care: Evidence, Mechanisms, And Guidelines, Mackenzie E. Unsworth, Mary Lou Galantino, Robert Sandoval

Oncology Rehabilitation in Practice

This article aims to provide a brief overview of the evidence and mechanisms for psilocybin use in EOL care. Additionally, this article will provide guidelines for clinicians to assess patient use and integrate psilocybin into their clinical practice with respect to its current legal status.

New Mode For 4 Mm Path Irradiation And One Side Detection At 0–180° For Cu (Ii)Ion Determination In Different Samples Using On-Line Continuous Flow Feed And Simplified, Sensitive, And Portable Photometer, Asma A. Gayed Al-Ani, Nagham S. Turkey Al-Awadie

Baghdad Science Journal

This study presents a rapid, sensitive, and straightforward approach for measuring Cu(II) ions using turbidity continuous flow injection analysis (CFIA) . The method involves reacting Cu(II) ion with calcium Ferro cyanide to produce a brown-red precipitate. To detect the attenuation of incident light as a result of collision on the surfaces of the precipitate particles, the analyzer NAG-SSP-5S-1D was used to measure turbidity at an angle (0–180°).

The linear range of Cu(II) measurements extends from 0.01 to 5 mmol.L^–1 with Correlation Coefficient of 0.9993 and R² % = 99.86 .The limit of detection (LOD) was determined to be …

High-Stakes Exams Inflate A Gender Gap And Contribute To Systematic Grading Errors In One Introductory Physics Series, David J. Webb, Cassandra Paul

Faculty Research, Scholarly, and Creative Activity

Previous research has suggested that changing the percentage of the course grade associated with exam grades in science, technology, engineering, and mathematics courses can change the gender gap in the course. It has also been shown that high-stakes assessments yield the lowest (relative) scores for female students. Previous research by the authors has shown that implementing retake exams can eliminate the gender gap in introductory physics courses. This paper explores several different hypotheses for why retake exams are associated with a zeroed gender gap. Two independent measurements comparing exams with different stakes are used in support of the argument that …

The Echo: October 20, 2025, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Timbre — A Transcendent Paradox?, Eugenia Siegel Conte

Yale Journal of Music & Religion

Timbre, as ethnomusicologist Cornelia Fales writes, is “paradoxical” precisely because it is one of the most exacting processes in which the human body may sense and comprehend the source of a sound even as that comprehended sound is impossible to describe outside of metaphor or comparison. As one of the more recognizable qualities of sound but the most difficult to describe, timbre allows us to consider physical/emotional (affective) experiences of sound as a key aspect of faith and meditation. In this article, I examine physical-affective intersections of faith and meditation that often are key to praxes of worship, and show …

Bifusenet: A Multimodal Network For Estimating Blood Alcohol Concentration Via Bidirectional Hierarchical Fusion, Abdullah Tariq, Arooba Maqsood, Martin Masek, Syed Zulqarnain Gilani

Research outputs 2022 to 2026

Drunk driving remains a significant public safety challenge, demanding innovative alternatives to conventional methods such as field sobriety tests and breathalysers. Estimating a driver's level of intoxication through facial cues is particularly challenging due to the subtle and person-specific nature of alcohol-induced behaviours. In this paper, we present BiFuseNet, a 3D spatio-temporal multi-modal network designed to classify alcohol impairment levels into three categories: sober, moderate, and severe. Unlike prior approaches that rely on either uni-modal RGB video or hand-crafted facial features, our method exploits complementary physiological cues from RGB and infrared (IR) facial videos. We introduce a Bi-directional Hierarchical Fusion …

2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Foundations Of Artificial Intelligence In Healthcare Diagnostics: A Systematic Survey, Raghad Tariq Al-Hassani

Al-Esraa University College Journal for Engineering Sciences

Artificial Intelligence (AI) is becoming the cornerstone of the future of healthcare diagnostics, that has to ability to change the healthcare diagnostic landscape in terms of diagnostic accuracy, speed, and availability. This systematic review investigates the basic methods, tools, applications, and challenges involved in the integration of AI in diagnostic medicine. It emphasizes the using of machine learning models, deep learning networks (e.g., CNNs), NLP for clinical documentation, and smart computing infrastructures, such as edge device and IoMT. They are making possible real-time, data-driven decision making that is already at human-expert-level performance or, in some cases, even better (in the …

Impact Of Microplastics Contaminated Food And Beverages On Reproductive And Mental Health, Lala Opeyemi Titilayo, Adisa Ayomide Funmilayo, Adelowo Joy Motunrayo, Oladapo Jesutomi Eniola, Oyekanmi Bolape Adeola, Lala Olusegun Gbenga, Afolabi Opeyemi Olanike, Ajayeoba Titilayo Adenike, Morakinyo Adetoun Elizabeth, Oladipo Elijah Kolawole, Oyowvi Mega Obukohwo, Oyedepo Temitope Adenike

Folia Medica Indonesiana

Microplastics, defined as plastic particles smaller than 5 mm, have emerged as a global environmental pollutant resulting from widespread plastic waste. Increasing concerns have been raised regarding their potential contamination of food and beverages, which may pose health risks to humans. This review aimed to evaluate current literature focusing on potential reproductive and mental health risks associated with the consumption of microplastic-contaminated food and beverages. A comprehensive literature search was conducted using multiple databases and Boolean operators to identify peer-reviewed English-language articles published within the past thirteen years. The review included studies that addressed microplastics in food and beverages, their …

The Effect Of Fascicular Elastin On The Mechanical And Functional Properties Of Healthy, Damaged, And Healing Tendon, Shawn Pavey

McKelvey School of Engineering Graduate Student Theses & Dissertations

Mechanical properties of tendon are highly influenced by structural protein composition and microscopic sub-structures. Within the largest subunit of tendon, the fascicle, the role of the elastin protein remains understudied despite impressive extensibility and fatigue resistance of its resulting elastic fibers. While previous work catalogued contributions of fascicular elastin across tendon type and species, the anticipated effects of elastin in fatigue and healing have not yet been explored. While previous knockout mouse models showed that disruption of elastic fibers led to altered mechanical properties (e.g., increased linear modulus), these models depended on heterozygous elastin deficiency or indirect knockout of proteins …

The Science Of Sound: Studying The Cognitive, Emotional, And Physiological Effects Of Frequency, Genre, And Music, Jett Yarborough

Senior Honors Theses

Music influences emotion, physiology, and cognition, yet little is known about how the frequency it is tuned to affects these influences. Prior research has shown that music tuned to 432 Hz can reduce stress, lower blood pressure, and improve sleep. My colleagues and I conducted two studies to investigate this. Our research found that music tuned to 432 Hz promotes a significant increase in memory retention and induces a state of focus and relaxation. These results suggest that shifting from the standard tuning frequency of 440 Hz to 432 Hz could have a profoundly positive impact on our daily lives. …

Check Out The Library, 2025 Fall Issue, Cal Poly Humboldt Library

Library Publications

Issue 20

Alternative Polyadenylation Contributes To Fibroblast Senescence In Pulmonary Fibrosis, Jingjing Huang, Maria Jose Gacha-Garay, Yu Wang, Scott D Collum, Rene A Girard, Hydia Puente, Seung-Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J Wagner, Hari Krishnayalamanchili, Harry Karmouty-Quintana, Zheng Chen, Tingting Mills

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens during aging, and the acquisition of a senescence-associated secretory phenotype (SASP) turns senescent fibroblasts into pro-inflammatory cells. However, the mechanism promoting senescence in IPF, especially at the post-transcriptional level, is poorly understood. We recently discovered that Nudix Hydrolase 21 (NUDT21, also named CFIm25), an RNA-binding protein, plays a critical role in regulating the expression of SASP factors through alternative polyadenylation (APA). APA allows adding poly(A) …

Thermoneutrality Does Not Affect Angiotensin Ii–Induced Aortic Aneurysms In Hypercholesterolemic Mice, Liyuan Zhu, Bowen Li, Michael K. Franklin, Deborah A. Howatt, Yuriko Katsumata, Alan Daugherty, Hong S. Lu

Physiology Faculty Publications

No abstract provided.

Capacity Of Gum Arabic As Immunomodulator And Antibacterial Agent Against Oral Cavity Periodontopathogen In Diabetes Mellitus Rats With Periodontitis, Tantin Ermawati, Suhartini, Tecky Indriana, Zahreni Hamzah

Journal of Dentomaxillofacial Science

Objective: This study aims to determine the benefits of gum arabic as an immunomodulatory and antibacterial drug therapy in the oral cavity of diabetic mellitus rats.

Material and Methods: Male wistar rats induced by diabetes mellitus accompanied by periodontitis and Gum Arabic therapy.  This study was divided into 5 treatment groups, namely group I (control), group II (diabetes mellitus) and group III (diabetes mellitus and periodontitis with P. gingivalis injection), group IV (diabetes mellitus treated with gum arabic), group V (diabetes mellitus with periodontitis and treated with gum arabic). The parameters studied were TNF-α anti-inflammatory mediators and the number of …

Illustrations For A Scientific Review Article Publication : Human Stem Cell-Derived Organoids, Sunghwan Bae

Theses

This thesis explores the role of scientific illustration in improving the comprehension of complex scientific concepts. It traces the historical development of illustrations in scientific literature and examines their functions in both research and review articles. The central contribution of this work is the development of twelve vector-based illustrations that elucidate the applications of human organoids within a review article context. These visuals transform intricate ideas into clear, engaging representations, supported by extensive research and verification to maintain scientific accuracy. The thesis concludes by addressing the future of scientific illustration, advocating for reader-oriented design approaches and the use of innovative …

अध्ययन, अध्यापन, अनुसंधान: Celebrating 270 Years Of Homoeopathy And Scientific Integration, Jyoti Sachdeva, Pankhuri Misra, Sonu Kumar, Divya Taneja, Renu Mittal, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The World Homoeopathy Day (WHD) 2025 convention, held on 10th–11th April 2025 at Mahatma Mandir, Gandhinagar, commemorated the 270th birth anniversary of Dr. Samuel Hahnemann, the founder of Homoeopathy. Organized by the Central Council for Research in Homoeopathy (CCRH), the National Commission for Homoeopathy (NCH), and the National Institute of Homoeopathy (NIH), under the Ministry of Ayush, the event witnessed an unprecedented gathering of 8,651 delegates, making it the largest-ever congregation of homoeopathic professionals, students, and researchers. Centered on the theme

अध्ययन, अध्यापन, अनुसंधान

(Education, Teaching, and Research), the event emphasised the integration of scientific research, clinical practice, and education …

Design Thinking Pedagogy In A Culture Of Information Immediacy, Ahu Yolac, Philip Plowright

Learn X Design Conference Series

This paper investigates design thinking pedagogy within the context of information immediacy, analysing student work from the Design Principles studio, an interdisciplinary introductory course for first-year students enrolled in five professional design programs. The course emphasizes foundational design thinking skills, including divergent and convergent thinking, abstraction, coherence, cohesiveness, and the hierarchical organization of project information. Through qualitative analysis of student projects, we identify three distinct patterns of engagement: procedural application, emerging integration, and flexible, critical workflow. These patterns reveal how students navigate and internalize design thinking tactics in an era of abundant information and digital tools. We discuss the pedagogical …

Defining Student Success: Whether Inconsistencies Impact Institutional Resources And The Ability To Meet Student Needs, Kathleen Swain

Student Theses and Dissertations

The term student success is frequently used in higher education, yet no universally accepted definition exists. This lack of a common understanding of what success means can lead to inconsistent priorities and practices across institutions. This qualitative case study explored how internal stakeholders at one community college define student success and whether discrepancies exist between their definitions. Guided by the framework of Maslow’s Hierarchy of Needs, this study addressed three research questions: (1) How do definitions of student success vary across community college stakeholder groups? (2) How do different community college stakeholders describe the relationship between the academic components of …