Digital Commons Network^™

Australian Fathers’ Experiences Of Caring For Their Preterm Infants, Esther Adama, Eric Adua, Evalotte Mörelius, Annie Chang, Ravisha Srinivasjois, Sara Bayes

Research outputs 2022 to 2026

Fathers and/or non-birthing partners are now actively involved in child-rearing globally; however some experience emotional difficulties during the perinatal period. With the birth of a preterm infant, parents experience additional stress beyond that normally engendered by having a baby, which can impact on parent-infant relationship and infant development. In Australia, there is limited evidence on fathers’ experiences of preterm birth. Thus, this study aimed to explore the experiences of Australian fathers of preterm infants including their emotional and physical wellbeing when they have a preterm infant. Narrative inquiry guided the study; 13 fathers whose preterm infant was admitted to Australian …

Automated Abdominal Aortic Calcification Scoring From Vertebral Fracture Assessment Images And Fall-Associated Hospitalisations: The Manitoba Bone Mineral Density Registry, Marc Sim, Abadi K. Gebre, Jack Dalla Via, Siobhan Reid, Mohammad Jafari Jozani, Douglas Kimelman, Barret A. Monchka, Syed Zulqarnain Gilani, Zaid Ilyas, Cassandra Smith, David Suter, John T. Schousboe, Joshua R. Lewis, William D. Leslie

Research outputs 2022 to 2026

Abdominal aortic calcification (AAC), a subclinical measure of cardiovascular disease (CVD) that can be assessed on vertebral fracture assessment (VFA) images during osteoporosis screening, is reported to be a falls risk factor. A limitation to incorporating AAC clinically is that its scoring requires trained experts and is time-consuming. We examined if our machine learning (ML) algorithm for AAC (ML-AAC24) is associated with a higher fall-associated hospitalisation risk in the Manitoba Bone Mineral Density (BMD) Registry. A total of 8565 individuals (94.0% female, age 75.7 ± 6.8 years) who had a BMD and VFA image from DXA between February 2010 and …

Balancing Digital Presents And Futures: Understanding First-Time Parents’ Practices, Plans And Perceptions Of ‘Quality’ And Risk In Young Children's Digital Engagements, Katrin Langton, Emma Jayakumar, Harrison W. See, Catherine Archer, Giselle Woodley

Research outputs 2022 to 2026

Parents in Australia today have to make decisions about what counts as appropriate digital media use for their young children in a cultural context characterised by conflicting advice, impractical screen use recommendations and risk-focussed media messaging. These conditions make it challenging for parents to purposefully approach and plan not only their children's current digital engagements but also their futures as digital citizens. How parents negotiate these tensions in managing their young children's digital presents, and how they approach planning for their digital futures, remains underexplored. This paper presents the findings of two rounds of qualitative interviews and three focus groups …

Bone Mineral Density In Childhood Cancer Survivors During And After Oncological Treatment: A Systematic Review And Meta-Analysis, Anna Maria Markarian, Dennis R. Taaffe, Francesco Bettariga, Hao Luo, Daniel A. Galvão, Jodie Cochrane Wilkie, Carolyn J. Peddle-Mcintyre, Robert U. Newton

Research outputs 2022 to 2026

Osteoporosis poses a significant concern for childhood cancer survivors (CCS). While recommendations for surveillance and management of bone mineral density (BMD) exist, no systematic review and meta-analysis has been undertaken to quantify BMD Z-scores in childhood cancer patients undergoing cancer treatment and survivors who have completed treatments. Accordingly, we conducted a systematic review with a 3-level mixed-effects meta-analysis to examine the course of BMD Z-scores in childhood cancer patients and survivors and identified possible moderators using meta-regression models. A systematic search was conducted in CINAHL, Embase, PubMed, SPORTDiscus, and Web of Science databases from inception to November 2023. We included …

Child And Family Centred Care: A Three-Phased Principle-Based Concept Analysis, Maggie Zgambo, Julie Blamires, Mandie Foster, Mohammad Al-Motlaq, Therese A. O'Sullivan, Davina Houghton, Evalotte Mörelius

Research outputs 2022 to 2026

Introduction: Despite a growing multidisciplinary interest in the Child and Family Centred Care approach, its meaning remains unclear in extant literature. It is, therefore, crucial to explore, analyse, describe, and clarify the concept of the Child and Family Centred Care approach and its associated terms. Method: A three-phased principle-based concept analysis approach was used to analyse the concept of Child and Family Centred Care. A systematic search of literature was completed using the CINAHL, PsycINFO, Medline, Scopus, and Web of Science databases. Peer-reviewed articles on Child and Family Centred Care, published from inception to 2023 were included if they were …

Co-Designing A Children's Transition Charter For The Transition To School: Opening Participatory Spaces To Hear Children's Voices, Lennie Barblett, Leanne Lavina, Fiona Boylan, Amelia Ruscoe

Research outputs 2022 to 2026

This project sought to gather the voices of young children to investigate whether a co-development process could be used to develop a transition to school charter with children and their teachers. Children's experiences of the transition to school can have far-reaching effects on their continuing educational journey. Seven teachers from the early years of school and 52 children (3–5 years) participated in the project over a school year. Participatory action research framed the study, which utilised child-centred methods for children to describe their dreams, hopes and aspirations of what school would be like and how their transition could be improved. …

Cultural Values And Practices In Alcohol And Other Drug Use Among Immigrant Youth: A Systematic Review, Abraham Kenin, Justine Dandy, Prince Atorkey, Sonam Pelden, Kwadwo Adusei-Asante, Byron L. Zamboanga

Research outputs 2022 to 2026

We systematically reviewed the literature to examine the cultural values and practices that can increase risk for or protect against Alcohol and Other Drugs (AOD) use among immigrant youth, and the variation of these risk and protective factors across socio-demographic contexts. We followed the preferred reporting items for systematic review (PRISMA) guidelines. We included quantitative studies that were conducted with immigrant youth between 12 and 35 years and measured cultural values as independent variables and AOD use as dependent variables. All studies were identified via PsycINFO, MEDLINE, CINAHL, EMBASE, and Scopus databases. We used a two-step screening process for all …

Design Of An Improved Robust Fractional-Order Pid Controller For Buck–Boost Converter Using Snake Optimization Algorithm, Seyyed Morteza Ghamari, Hasan Molaee, Mehrdad Ghahramani, Daryoush Habibi, Asma Aziz

Research outputs 2022 to 2026

With the increasing complexity of modern power systems, effective control of DC–DC converters has become crucial to ensure stability and efficiency. This paper focuses on optimizing the parameters of a known fractional-order proportional–integral–derivative (FOPID) controller for the control of a DC–DC buck–boost converter. The control of a DC–DC buck–boost converter is achieved using aFOPID approach. The gains of this technique have been enhanced utilizing the snake optimization (SO) algorithm. This converter exhibits unfavourable behaviour due to its non-minimum structure, necessitating a well-regulated controller to guarantee stability. The fractional concept is suggested here to enhance the dynamics of the classical PID …

Psychological Implications Of Preterm Birth, Livio Provenzi, Minesh Khashu, Mia Mclean, Evalotte Morelius

Research outputs 2022 to 2026

No abstract provided.

Effects Of A Daily, Home-Based, 5-Minute Eccentric Exercise Program On Physical Fitness, Body Composition, And Health In Sedentary Individuals, Benjamin J.C. Kirk, Georgios Mavropalias, Anthony J. Blazevich, Jodie L. Cochrane-Wilkie, Aus Molan, Kazunori Nosaka

Research outputs 2022 to 2026

Purpose: This study examined the effects of a 4-week home-based bodyweight eccentric exercise program, requiring just 5 min daily, on physical fitness, body composition, and both physical and mental health in sedentary individuals.

Methods: Twenty-two sedentary but healthy individuals (4 men, 18 women; 32–69 years) completed a two-week control period followed by a 4-week intervention. The intervention involved daily exercises consisting of 10 repetitions each of chair squats, chair reclines, wall push-ups, and heel drops, including progressions if necessary. Assessments included isometric mid-thigh pull (IMTP), handgrip (HG) strength, push-up and sit-up endurance, sit-and-reach (S&R) flexibility, 3-min step test (3ST), squat …

Efficacy Of A School-Based Mental Health Intervention Among Zambian Youth: A Cluster-Randomized Controlled Trial, Sherinah Saasa, Kaitlin P. Ward, Cleopas G. Sambo, Paula Barrett, Cheuk Yan Lau

Research outputs 2022 to 2026

While many children in Africa face notable psychological problems, the majority do not receive needed mental health services. The My FRIENDS Youth Program, a universal cognitivebehavioral intervention for anxiety prevention and resilience enhancement, has demonstrated effectiveness across cultures in children and adolescents. This study explores whether the program's effectiveness extends to Zambian children. Participants were 75 children and adolescents (53% female, ages 10-15) attending low-income schools in Zambia. Four schools were randomly assigned to an intervention (n=44) or waitlist control (n=31). The intervention consisted of 10 weekly sessions plus two booster sessions administered in group format. Assessments were conducted at …

Exploring The Barriers To Mental Health Help-Seeking Among African Migrants In Australia: A Qualitative Study, Nnaemeka Meribe, Obed Adonteng-Kissi, Kathomi Gatwiri, Lillian Mwanri, Frank Darkwa Baffour, Agness Tembo, Edith N. Botchway-Commey, David Chisanga, Ahmed A. Moustafa, Kerrie E. Doyle, Uchechukwu Levi Osuagwu

Research outputs 2022 to 2026

Background: The health of African migrants in Australia is a largely under-researched topic despite the steadily increasing size of the population and its uniqueness. In particular, few studies have explored the mental health of African migrants in Australia or their utilization of mental health services.

Aims: This study explored the barriers to mental health help-seeking among first-generation African migrants in Australia.

Methods: In this qualitative study conducted using the hermeneutical phenomenological research approach, the purposive sampling method was used to recruit participants. In-depth interviews with participants were undertaken online via Zoom, Teams, and WhatsApp calls. Interviews were recorded and transcribed …

Finding Their Place: How Teachers Can Become Part Of Their Rural Communities, Mary-Anne Macdonald, Sarah Booth, Kirsten Lambert, Christina Gray, Terry Ngarritjan Kessaris, Takeia Beard

Research outputs 2022 to 2026

The tyranny of distance is often perceived as the greatest challenge for teacher retention in rural and remote schools in Australia. Perhaps more accurately, it is the tyranny of placelessness. In this paper, we explore the role of place-connectedness and racial literacy in shaping the interactions of 21 primary and secondary teachers with the social space and place of one Western Australian remote town. Data were collected through interviews and focus groups and analysed with an emergent approach. We propose three levels of place-consciousness to describe the depth of awareness, skill and integration with which a teacher might connect to …

Fostering A Resilient Healthcare System: Supportive Practice Environment Initiatives To Support Nurse And Midwives A Scoping Review, Gemma Doleman, Dianne Bloxsome, Rong Wang, Lisa Whitehead

Research outputs 2022 to 2026

Aim: This scoping review aimed to explore supportive practice environment initiatives that support novice and expert nurses and midwives. Design: Scoping review. Methods: Studies were identified through the electronic databases Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, PsychInfo, Scopus, and Web of Science. Grey literature was searched using GreyNet, National Grey Literature Collection, ProQuest Dissertation and Theses, and Google Scholar. Results: Thirty-one papers met the criteria for inclusion and data extraction. The key concepts identified were the need for adequate staffing and resources, clear and regular communication, managerial presence and engagement in committees and relationship building, celebration …

Gestational Age–Specific Prevalence Of Preeclampsia Among Pregnant Women In Ghana: A Hospital-Based Retrospective Observational Study, Wina Ivy Ofori Boadu, Enoch Odame Anto, Akua Benewaah Asamoah, Ezekiel Ansah, Godfred Yawson Scott, Emmanuel Ekow Korsah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Michael Nyantakyi, Agartha Odame Anto, Emmanuel Timmy Donkoh, Kwame Ofori Boadu, Richard Vikpebah Duneeh, Frederick Ayensu, Christian Obirikorang

Research outputs 2022 to 2026

Background: Preeclampsia is responsible for a significant rate of maternal morbidity and mortality worldwide. Gestational age as a risk factor has a significant impact on fetal outcomes in pregnancies affected by preeclampsia. However, to our knowledge, no study has identified the gestational age–specific prevalence of preeclampsia in Ghana. Thus, this study ascertained the gestational age–specific prevalence of preeclampsia as well as its associated factors. Methods: A hospital-based retrospective observational study was conducted by reviewing data collected from the maternal birth register on 619 pregnant women who delivered at the facility from 1st January 2021 to 31st December 2021. Results: Out …

Ghostbusters: Hunting Health Education Within Physical Education, Valeria Varea, Ana Riccetti

Research outputs 2022 to 2026

Purpose: The school subject of physical education (PE) has experienced a “health turn” globally. However, some university undergraduate programs may need to be revised to adequately equip pre-service teachers to teach about health in schools. The aim of this study was to explore the content of an undergraduate university program in PE and what is expected for pre-service PE teachers to teach about health in schools, according to the relevant curricula. Design/methodology/approach: A pragmatic discourse analysis was conducted, using the Argentinean PE school curriculum for primary and secondary schools in the province of Córdoba and the syllabus of an undergraduate …

Health Professional Perceptions Of Delivering Hospital Falls Prevention Education—A Qualitative Study, Anne Marie Hill, Cheng Yen Loo, Steffanie Coulter, Carol Watson, Sharmila Vaz, Meg E. Morris, Leon Flicker, Tammy Weselman

Research outputs 2022 to 2026

Background: Providing patient falls prevention education can help reduce falls in hospitals, yet research exploring staff perceptions about providing falls education in hospitals is limited. Objective: We sought to determine enablers and barriers to implementing a hospital falls prevention education program (the Safe Recovery Program) from the clinical staff perspective. Methods: Purposive sampling was used to recruit health professionals (N = 40) from 12 acute medical and surgical wards at a 450-bed hospital in Perth, Western Australia. Participants were given the option to take part in a focus group or semi-structured interview. Data were analyzed via directed content analysis. Results: …

Immunoglobulin G N-Glycome As A Biomarker Of Mortality Risk In Escherichia Coli Induced Sepsis, Huachen Wang, Houqiang Li, Zheng Guo, Hongda Hou, Haifeng Hou, Bing Chen

Research outputs 2022 to 2026

Background: Sepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis. The role of immunoglobulin G N-glycome in estimating the mortality in patients with sepsis remains unknown. This study aims to reveal the clinical application of immunoglobulin G N-glycome as a potentially novel biomarker to predict mortality risk in Escherichia coli-induced sepsis. Methods: The serum immunoglobulin G N-glycome levels in 100 adult septic patient serum samples on the day of intensive care unit (ICU) admission, and 100 …

Investigating The Internal And External Load Associated With Umpiring Semi-Professional Australian Rules Football, Corey Wilson, Mark Scanlan, Colin S. Doherty, Oliver R. Barley

Research outputs 2022 to 2026

Background: This investigation examined internal and external load associated with umpiring semi-professional Australian Rules football, an area of limited research. Objective: This exploratory quantitative study recruited 39 field umpires (Age: 25.2 ± 6.8 y, Body Mass: 74.6 ± 7.9 kg, Height: 178.9 ± 7.4 cm) from the Western Australian Football League (WAFL). Each participant was assessed in one match only. Methodology: External measures (total distance [TD], floating distance [FSD], high-intensity running distance [HSD]) and internal measures (blood lactate [BLa], heart rate [HR], rating of perceived exertion [RPE]) were collected during 22 matches, of the 2023 WAFL season. Data collection was …

Investigating The Interplay Of Thermal, Lighting, And Acoustics In Intensive Care For Enhanced Patient Well-Being And Clinical Outcomes, Emil E. Jonescu, Edward Litton, Benjamin Farrell

Research outputs 2022 to 2026

This research explores the interplay among noise levels, thermal conditions, and lighting intensity in an intensive care unit (ICU), focusing on preserving circadian rhythm and promoting nighttime sleep to advance patient-centric care. This investigation assesses lighting levels (Lux), natural versus artificial light ratios, ICU room temperature, and correlations with acoustic data during a field research period and examines the collective impact of patient exposure to sleep linked to delirium and health outcomes, addressing critical gaps in understanding. Findings reveal that noise levels between 60 and 90 dB(A) during patient occupancy exceed sleep disruption thresholds, with daytime averages of 53.6 dB(A) …

Kaartdijin Bidi (Learning Journey): Place-Based Cultural Regeneration At University, Sandra Wooltorton, Lauren Stephenson, Kathie Ardzejewska, Len Collard

Research outputs 2022 to 2026

Imagine being in a university that functions in a place-based culturally regenerative way. In this concept paper, the authors bring together theory, practice, and experience, in the service of transforming universities towards place-based cultural regeneration. At present, Australian universities operate using an economic philosophy of neoliberal corporatism characterised by hierarchical management strategies, competitive tendencies, patriarchal values, and discourse characterised by bifurcation or binary thinking. These features illustrate a worldview that is entangled with the meta crises of our times such as climate change, species loss, hatred/intolerance, and unfathomable violence. The authors consider ways of moving towards a place-based, Indigenous-informed, practical, …

Molecular Testing Of Lung Cancer In Australia: Consensus Best Practice Recommendations From The Royal College Of Pathologists Of Australasia In Collaboration With The Thoracic Oncology Group Of Australasia, Wendy A. Cooper, Benhur Amanuel, Caroline Cooper, Stephen B. Fox, Jon W.A. Graftdyk, Peter Jessup, Sonja Klebe, Wei Sen Lam, Trishe Y.M. Leong, Zarnie Lwin, Rachel Roberts-Thomson, Benjamin J. Solomon, Rebecca Y. Tay, Rebecca Trowman, Janney L. Wale, Nick Pavlakis

Research outputs 2022 to 2026

Molecular testing plays a critical role in guiding optimal treatment decisions for lung cancer patients across a variety of clinical settings. While guidelines for biomarker testing exist in other jurisdictions, to date no best practice guidelines have been developed for the Australian setting. To address this need, the Royal College of Pathologists of Australasia collaborated with the Thoracic Oncology Group of Australasia to identify state-based pathologists, oncologists and consumer representatives to develop consensus best practice recommendations. Sixteen recommendations were established encompassing appropriate biomarkers, lung cancer subtype, tumour stage, specimen types, assay selection and quality assurance protocols that can inform and …

Nivolumab Plus Chemotherapy Or Ipilimumab In Gastroesophageal Cancer: Exploratory Biomarker Analyses Of A Randomized Phase 3 Trial, Kohei Shitara, Yelena Y. Janjigian, Jaffer Ajani, Markus Moehler, Jin Yao, Xuya Wang, Aparna Chhibber, Dimple Pandya, Lin Shen, Marcelo Garrido, Carlos Gallardo, Lucjan Wyrwicz, Kensei Yamaguchi, Tomasz Skoczylas, Arinilda Bragagnoli, Tianshu Liu, Michael Schenker, Patricio Yañez, Ruben Kowalyszyn, Michalis Karamouzis, Thomas Zander, Kynan Feeney, Elena Elimova, Parul Doshi, Mingshun Li, Ming Lei

Research outputs 2022 to 2026

First-line nivolumab-plus-chemotherapy demonstrated superior overall survival (OS) and progression-free survival versus chemotherapy for advanced gastroesophageal adenocarcinoma with programmed death ligand 1 combined positive score ≥ 5, meeting both primary end points of the randomized phase 3 CheckMate 649 trial. Nivolumab-plus-ipilimumab provided durable responses and higher survival rates versus chemotherapy; however, the prespecified OS significance boundary was not met. To identify biomarkers predictive of differential efficacy outcomes, post hoc exploratory analyses were performed using whole-exome sequencing and RNA sequencing. Nivolumab-based therapies demonstrated improved efficacy versus chemotherapy in hypermutated and, to a lesser degree, Epstein–Barr virus-positive tumors compared with chromosomally unstable and …

Rapid Weight Loss Across Combat Sports And The Relationships Between Methods And Magnitude, Oliver R. Barley, Craig A. Harms

Research outputs 2022 to 2026

This study examined rapid weight loss (RWL) habits across combat sports (CS) and how common usage of different methods was related to the magnitude of RWL. Competitors (N = 256) from CS including boxing, Brazilian jiu-jitsu, muay thai/kickboxing (MT/KB), wrestling, mixed martial arts (MMA), judo, taekwondo, and karate participated in the study. Athletes completed an online survey which included questions on their regular weight loss habits, including magnitudes of weight loss over different time periods and types of methods utilised. Athletes typically started losing weight in their early 20s and engaged in RWL on average three times a year. Magnitudes …

School Infrastructure Procurement By Public–Private Partnership: In The Public Interest?, Leon Benade

Research outputs 2022 to 2026

The use of Public–Private Partnerships (PPPs) in the education sector to construct and maintain schools’ infrastructure is under-researched by Educational Studies specialists. This article presents an assay of the use of PPP to procure school facilities, notably in developed contexts, where PPP arrangements are typically a product of the neoliberal privatisation of education. PPP arrangements allow governments to contract private sector partners to finance, design and construct school facilities infrastructure in exchange for state payments. The evaluation is complemented by a critical analysis of the WA Schools Public Private Partnership Project and three published Australian-based case studies. This sets the …

School Library Professionals’ Perceptions Of Students’ Digital Information Literacy, Margaret Kristin Merga, Saiyidi Mat Roni

Research outputs 2022 to 2026

Young people need strong digital information literacy (DIL) skills to effectively source, interpret and evaluate the credibility of online information. As DIL educators and advocates within contemporary schools, school library professionals can provide cross-contextual insights into their students’ DIL knowledge, skills and learning opportunities. Data from the 2024 International School Library Workforce Survey suggest that developing DIL may not be a typical priority in all schools and countries. Students’ DIL was felt to be low. School library professionals may be underutilized for supporting DIL learning in 35% of contexts, highlighting the need for greater understanding of this professional role.

Sleep In Residential Aged Care: A Secondary Qualitative Analysis Of Data From The Australian Royal Commission Into Aged Care Quality And Safety, Aisling Smyth, Patricia Cain, Sabine Pangerl, Christopher Gordon, Kasia Bail, Davina Porock

Research outputs 2022 to 2026

Background:

Sleep is a crucial healing and restorative component of older person care but is often negatively impacted through the effects of institutionalization in residential aged care (RAC). Currently, information about how sleep occurs is limited.

Methods:

Through the lens of person-centered care, this study examined submissions to the Australian Royal Commission into Aged Care Quality and Safety. The Commission was established in 2018 with the aim of protecting and improving the safety, quality of life, and well-being of people receiving aged care. The commission received 10 000+ submissions from a range of stakeholders, including consumers, family members, expert witnesses, …

Social Exclusion Of Refugees With A Disability In Australian Society Within The Context Of Healthcare Quality Theory And E-Health, Hossein Adibi

Research outputs 2022 to 2026

The phrase social exclusion came to Australia via Britain. Discussion on 'inclusion and exclusion' mainly focus on those individuals and groups living in poverty. Socially excluded occurs as a result of many factors, based on sex, race, ethnic origin, religion, sexual orientation, and disability. Until 2012 people with a disability were excluded from Australian' resettlement programs representing a significant discrimination concern. As a result of strong opposition to this issue, the policy changed in 2012 and the number of refugees with disabilities increased. This in turn led to more ethnic diversity of people with disabilities within NDIS. However, since NDIS …

Sports Metaresearch: An Emerging Discipline Of Sport Science And Medicine, John Warmenhoven, Paolo Menaspà, David N. Borg, Simine Vazire, Nicole White, Kristin Sainani, Sophia Nimphius, Aaron J. Coutts, Franco M. Impellizzeri

Research outputs 2022 to 2026

Inadequacies in the conduct and quality of research are well established across many research domains, including sport science and medicine. Metaresearch—the practice of performing research on research—is presented as a practical vehicle for improving research quality through evaluating the research processes. This article introduces the concept of metaresearch to sport as a new sub-field of sport science. The broad types of metaresearch are introduced, with a mapping of current sports metaresearch activity across these areas. Interdisciplinary centres aimed at improving scientific quality across other fields are also introduced to sport, and specific considerations for beginning metaresearch are provided for sport. …

Survival After Cessation Of Immunotherapies In Melanoma: A Systematic Review And Meta-Analysis, Kristine E. Mayer, Lydia Warburton, Anne Zaremba, Sarah Preis, Yannick Foerster, Tilo Biedermann, Oana Diana Persa

Research outputs 2022 to 2026

Background: Immune-checkpoint inhibitor (ICI) therapy elicits durable responses in a subset of patients with advanced melanoma. However, the appropriate timing for treatment cessation remains an unresolved issue. Moreover, some patients are required to discontinue therapy due to the occurrence of severe adverse events. Upon treatment cessation, a subset of patients maintains a durable response, while some patients relapse and require rechallenge with ICI. Criteria for a safe stop of ICI have not been established. Objectives: The aim of this systematic review and meta-analysis was to evaluate the durability of response in melanoma patients who discontinued ICI therapy. Furthermore, the outcome …