Digital Commons Network^™

Speculative Documentary As World-Building: Contaminated Knowledge And Future-Making, Cassandra Tytler

Research outputs 2022 to 2026

In the context of climate emergency and growing mistrust in knowledge institutions, both science and documentary practice have often been positioned as neutral authorities. Yet the knowledge they produce is shaped by political, social, and material conditions. This paper presents a creative practice research project that uses speculative documentary to trouble dominant narratives of truth and objectivity. Rather than rejecting science, it critiques the authority of singular truth claims in both scientific and documentary domains, asking how knowledge is constructed and maintained. The analysis centres on It Will Not Be Pure, a multi-channel video installation created as a form of …

Work Hard, Play Hard, Drink Hard: Frontier Masculinities And Female Teachers’ Experiences In A Regional Australian Mining Town, Kirsten Lambert, Christina Gray, Mary Anne Macdonald, Takei Beard, Kelly Jackson, Sarah Booth

Research outputs 2022 to 2026

Teacher attrition is a significant issue that has been the subject of much recent critical research and public debate. What is less often explored in the literature is the gendered nature of teaching and the unique struggles female teachers face in the workforce, particularly in remote, regional and rural (RRR) schools. As a historically female-dominated profession, women, particularly teacher-mothers face a distinctive set of barriers to career progression in these schools. We apply a critical feminist lens to qualitative data generated from interviews with 21 teachers from 6 different schools in RRR locations in Western Australia. Data reveals a toxic …

Association Of High-Sensitivity Cardiac Troponin I Levels Below The Sex-Specific 99th Percentile With Late-Life Dementia: The Perth Longitudinal Study Of Ageing Women, Carlos J. Toro-Huamanchumo, Abadi Kahsu Gebre, Tiago Pecanha, Craig Sale, Wai Lim, Elizabeth Byrnes, Ee Mun Lim, Simon Laws, Kun Zhu, Carl Schultz, Richard L. Prince, Blossom C.M. Stephan, Mario Siervo, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Background: Elevated high-sensitivity cardiac troponin (hs-cTn) levels are linked with cardiovascular disease and cognitive impairment, both of which are strong risk factors for late-life dementia (LLD). This study examined the association between hs-cTnI levels below the sex-specific 99th percentile for myocardial injury and the incidence of LLD in older women. Methods: 986 community-dwelling women aged ≥70 years without prior LLD and with hs-cTnI < 15.6 ng/L (stratified into quartiles) were included from the Perth Longitudinal Study of Ageing Women. The primary outcome was incident LLD events, including LLD hospitalisation or death, over 14.5 years obtained from linked health records. Associations between hs-cTnI and LLD outcomes were explored using multivariable-adjusted Cox models, as part of restricted cubic splines. Results: At baseline, participants' mean (±SD) age was 75.2±2.7 years. Over 14.5 years of follow-up, LLD events (n=174, 17.7%), hospitalisations (n=155, 15.7%) and deaths (n=68, 6.9%) were recorded. Compared with those in the lowest quartile (Q1, median 3.1 ng/L), women in the highest quartile of hs-cTnI (Q4, median 7.3 ng/L) had a greater risk of developing LLD-related events (adjusted HR: 1.88, 95% CI: 1.22 to 2.91), hospitalisation (adjusted HR: 1.65, 95% CI: 1.04 to 2.64) and death (adjusted HR: 2.27, 95% CI: 1.13 to 4.59), after adjusting for established cardiovascular and dementia risk factors, including apolipoprotein E (APOE) genotype. Conclusion: Among older women, hs-cTnI levels below the sex-specific 99th percentile for myocardial injury were associated with an increased risk of LLD events over 14.5 years. These findings suggest that hs-cTnI may identify older women at higher risk of LLD, capturing both cardiovascular and brain health vulnerability in older age.

Establishment Of Reference Intervals For Serum Immunoglobulin G N-Glycosylation Features In Healthy Chinese Adults: A Nationwide Survey In The Framework Of Predictive, Preventive, And Personalized Medicine, Changyu Liu, Yinghao Wang, Xingang Li, Xiaojia Xu, Ruirui Xu, Cuihong Tian, Zhixian Chen, Xinxia Lu, Yuejin Li, Meng Wang, Zhaoyang Tang, Xueyu Chen, Guoyong Ding, Xuerui Tan, Dong Li, Haifeng Hou, Wei Wang

Research outputs 2022 to 2026

Background: Immunoglobulin G (IgG) N-glycosylation plays a vital role in the pathogenesis of autoimmune disorders, inflammatory diseases, and viral infections. While various models of serum IgG N-glycosylation have been developed to identify individuals at high risk for relevant diseases, reference intervals (RIs) for the levels of IgG N-glycans have not been established yet. Identifying RIs for serum IgG N-glycans closely associated with biological aging and disease risk contributes to predictive, preventive, and personalized medicine (PPPM/3PM), which results in improvement of patients’ outcomes, enhancement of healthcare efficiency, and in reducing burden of chronic diseases. This study is aimed at defining the …

Entrepreneurship: A Practical Guide For Business Success, Jalleh Sharafizad, Violetta Wilk, Kerry Brown, Aglae Hernandez Grande, Fleur Sharafizad, Dorothy Wardale

Research outputs 2022 to 2026

This book is tailored for entrepreneurs in their startups or moving to the next stage of their businesses, micro and small business owners, as well as individuals who are considering starting their own ventures. It brings together essential insights, practical tools, and valuable resources developed through two Western Australian government initiatives focused on entrepreneurial training and support. In addition, it draws on a range of business concepts from other sources, refining and simplifying them to suit the specific needs of emerging and growing enterprises.

Designed to be both flexible and supportive, the book serves multiple roles throughout your entrepreneurial journey. …

Beyond The Classroom Walls: Outdoor Education For Pre-Service Early Childhood Teachers, Sebnem Cetken-Aktas, Gunes Ezgi Demirci, Serap Sevimli-Celik

Research outputs 2022 to 2026

Outdoor education, an experiential approach that fosters sensory engagement and connections with the natural world, is increasingly recognized as an important aspect of early childhood education. However, there is a notable gap in preparing pre-service early childhood teachers to implement outdoor pedagogy effectively. This study examines how pre-service teachers evaluated their experiences in a course titled Outdoor Education in Early Years, designed to equip them with the confidence and skills for outdoor teaching in early childhood contexts. Seven early childhood pre-service teachers, aged 21 to 23, participated in the study, which employed purposive sampling. Data collection included one-on-one interviews, focus …

Desiring Education, Exhibiting Agency, Experiencing Systemic Obstacles: Re-Examining The Perceptions And Experiences Of Education Among Indigenous And Non-Indigenous Students In Australia, Mary Anne Macdonald, Eyal Gringart, Terry Kessaris, Renae Isaacs-Guthridge

Research outputs 2022 to 2026

We present new findings from a Western Australian mixed-methods study exploring a sample of Indigenous and non-Indigenous secondary school students’ (N = 536) experiences and perceptions of school. Respondents hailed largely from remote or regional Western Australia, although approximately half attended boarding school. This article presents findings of multivariate analysis of responses to the Multi-Dimensional Student Perceptions of School Questionnaire (MSPSQ) and identifies that Indigenous and non-Indigenous students in this study were found to be equally likely to report a positive perception of the benefit of education and the importance of attending and completing year 12, and equally likely to …

Exercise Parameters To Consider For Achilles Tendinopathy: A Modified Delphi Study With International Experts, Yoann Demangeot, Seth O’Neill, Francis Degache, Amandine Rapin, Umer Asgher, Hakan Alfredson, Rachel Chester, Ruth L. Chimenti, Robert Jan De Vos, Adrian Escriche-Escuder, Kenneth Farnqvist, Bas Habets, Nicola Maffulli, Stig Peter Magnusson, Peter Malliaras, Myles C. Murphy, Craig R. Purdam, Jonathan D. Rees, Ebonie K. Rio, Igor Sancho, Alex Scott, Karin Gravare Silbernagel, Vincent Gremeaux, Francois C. Boyer, Redha Taiar

Research outputs 2022 to 2026

To assess the level of agreement among experts on the heel raise exercise parameters that influence midportion and insertional Achilles tendinopathy (AT) rehabilitation outcomes. An international expert panel in AT rehabilitation was invited to complete a three-round Delphi survey. In the first two rounds, experts were asked to review a pregenerated list of exercise parameters (based on the heel raise exercise) and rate their perceived influence on rehabilitation outcome, using a 5-point Likert scale. For each parameter, consensus criteria for major influence on rehabilitation were (a) median≥4, (b) ≥75% of scoring 4 or 5 and (c) IQR≤1. The third round …

From ‘Raise The Age’ To ‘Raise The Awareness’: How Knowledge Affects Public Opinion Of The Minimum Age Of Criminal Responsibility In Western Australia, Suzanne Rock, Natalie Gately, Piero Moraro, James L. Finney

Research outputs 2022 to 2026

The minimum age of criminal responsibility (MACR) in Western Australia is 10 years old. While the negative impacts of early contact with justice systems have been well-documented and have resulted in calls to raise the age, research had not examined the public views of MACR in Western Australia. This article presents a novel examination of the knowledge and perceptions of the MACR with a sample of the West Australian public (n = 69). Findings from the semi-structured interviews revealed low levels of knowledge about the MACR, some reacted with surprise when provided with the information. Participants’ views shifted in that …

Perception-Based Methods And Beyond: A Current Opinion On How To Assess Static Stretching Intensity, Konstantin Warneke, Anthony J. Blazevich, Daniel Jochum, David G. Behm, Ewan Thomas, Masatoshi Nakamura, José Afonso

Research outputs 2022 to 2026

Muscle stretching is widely used in clinical, athletic, and otherwise healthy populations, yet a consensual definition of stretch intensity—a key component of stretch load—does not exist. This is important because the effects of stretch intensity on range of motion and strength are controversial but suggested to affect clinical practice and scientific research. Most commonly, stretch intensity is defined in relation to an individual’s perceived level of discomfort or pain; however, these definitions are problematic for several reasons, including that consensual and objective quantifiable definitions of ‘pain’ and ‘discomfort’ do not exist, perceptions vary widely (and may not be sensed in …

Prognostic And Predictive Value Of Gastric Acid Suppressants In The Eortc 1325/Keynote-054 Randomized Phase Iii Trial Of Pembrolizumab Vs Placebo In Resected Stage Iii Melanoma, Emanuel Bührer, Nina Glassee, Michal Kicinski, Oliver J. Kennedy, Christian U. Blank, Georgina V. Long, Victoria G. Atkinson, Stéphane Dalle, Andrew M. Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Marye Boers-Sonderen, Anna Maria Di Giacomo, Alfonsus J.M. Van Den Eertwegh, Jean Jacques Grob, Ralf Gutzmer, Rahima Jamal, Alexander C.J. Van Akkooi, Sara Gandini

Research outputs 2022 to 2026

Background: The gut microbiome plays a pivotal role in regulating immunity. Gastric acid suppressants (GAS) are known to alter the gut microbiome and might therefore modify response to immunotherapy in cancer patients. We estimated associations of GAS with recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) in the EORTC 1325/KEYNOTE-054 trial. Methods: Patients with resected stage III melanoma were randomized to receive 200 mg of pembrolizumab or placebo. Pembrolizumab prolonged RFS and DMFS (reported elsewhere). We used Cox models to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for the association between GAS at baseline, and RFS and …

Students As Designers Of Digital Games, Damian Maher, David A. Martin, Natalie Mcmaster, Stefan Schutt, Ben Zunica

Research outputs 2022 to 2026

Designing, programming, and using digital games are highly engaging activities and can be effective instructional approaches for supporting student learning. Often, students are users of the games rather than taking on the role of designers and developers, the latter of which requires computational and design thinking skills. This chapter presents a background on digital game design, the rationale for teaching and learning using digital game design, design tools, and examples of students as designers of digital games with links to curriculum outcomes. Drawing on research, the benefits, topics for inclusion, and pedagogical considerations involved in digital game design are investigated. …

Students As Designers With 3d Design And Fabrication Technologies, Carol Puddicombe, Rob Rouse, Marco Tolomei, David Ellis

Research outputs 2022 to 2026

This chapter explores integrating 3D design and fabrication technologies into educational settings, emphasising their potential to enhance student creativity, problem-solving skills, and real-world capabilities. Through using 3D design and fabrication tools such as computer-aided design (CAD) software, 3D printers, laser cutters, and computer numerical control (CNC) machines, students can transition from passive learners to active creators, engaging with tangible projects that connect theoretical concepts and practical challenges. The chapter highlights the importance of supporting teachers in adopting these technologies, addressing challenges such as hardware costs, software accessibility, and teacher training. By progressively increasing project complexity and incorporating real-world applications, educators …

The Multifaceted Interplay Between Covid-19-Induced Psychological Stress, Cognitive Flexibility, Emotional Overeating, And Physical Activity Patterns In Adult Women: A Mediated Path Analysis, Siavash Naddafha, Mandana Sangari, Zohreh Eskandari, Robabeh Shahnahadd, Christopher B. Taber

Research outputs 2022 to 2026

Objective: To determine how COVID-19-related stress influences food consumption and emotional overeating in adult women, and whether cognitive flexibility and physical activity mediate these relationships. Methods: In this cross-sectional study, 303 women (20–50 y) completed validated Persian versions of the COVID Stress Scale-18, Adult Eating Behaviour Questionnaire, Self-Regulation of Eating Behaviour Questionnaire, Cognitive Flexibility Scale, and Rapid Assessment of Physical Activity. Data were collected online via the ISO-27001-certified “Press Line” platform (end-to-end encryption). Chi-square tests and Spearman’s rank correlations were performed in SPSS 19 (α = 0.05). Results: COVID-19 stress was strongly inversely associated with cognitive flexibility (rₛ = – …

Transdisciplinary Work-Integrated Learning’S Contribution To Societal Transition: A Scoping Review, Denise Jackson, Claire Lambert, Sonja Coetzee

Research outputs 2022 to 2026

This scoping review explores the perceived value of transdisciplinary work-integrated learning (TWIL) for contributing to social change and the enablers of impactful TWIL offerings. TWIL is a pedagogy-based approach which connects students from diverse disciplines with external partners to engage in authentic, work-focused activities as a formal component of academic study. This review focuses on TWIL where students collaboratively explore and problem-solve on known local community and wider societal issues, such as climate, health, food, and water, to foster transformative practice. Thematic analysis of 31 academic sources highlighted the recognised worth of TWIL for fostering student skills for transformation, developing …

Maternal Nutriture And Concurrent Wasting And Stunting Among Under-Five Children: A Systematic Review, Aileen R. De Juras, Rodesa N. Forcadilla, Mary Ann M. Ingua, Angeline A. Bueno

Journal Article

Concurrent wasting and stunting (WaSt) is a severe form of child undernutrition associated with increased morbidity and mortality. While maternal nutritional status independently influences wasting and stunting, its role in their co-occurrence among children remains insufficiently explored. This systematic review aimed to examine associations between WaSt and maternal nutritional status and related determinants, as well how WaSt is defined, measured, and reported. It was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered with PROSPERO International Prospective Register of Systematic Reviews (CRD42024493969). Structured searches in Scopus, Web of Science, and Cochrane databases were …

Evaluation Of Bacterial Contamination On Flush Levers And Faucet Tap Handles In The Institute Of Biological Sciences Building Restrooms, University Of The Philippines Los Baños, Jan Patricia S. Estillore, Ronilo Jose D. Flores, Renard M. Jamora

Journal Article

Public restrooms provide convenience outside the home but are frequented by many users daily, creating a risk of microbial contamination on commonly touched surfaces such as flush levers and faucet handles. This study assessed microbial loads on these surfaces across genders and floors and aimed to isolate antibiotic-resistant Staphylococcus species and characterize Enterobacteriaceae. Samples were collected from flush levers and faucet handles across three floors of Wing C, Institute of Biological Sciences, University of the Philippines Los Baños, Laguna, Philippines. Results showed that faucet handles (7.9 × 109CFU/cm2) harbored higher microbial loads than flush levers (5.3 × 109CFU/cm2), and female …

Broader Consequences Of 17Α-Methyltestosterone-Induced Masculinization In Betta Splendens: Toxicological, Behavioral, And Morphometric Outcomes, Imee Rose E. Felipe, Alexandra May R. Rosario, Vijay Hanz A. Tuason

Journal Article

The 17α-methyltestosterone (MT) is a synthetic androgen widely applied in aquaculture, particularly in fish species like Betta splendens, where males have higher commercial value. While MT is effective for sex reversal, the broader physiological and behavioral consequences of MT exposure remain insufficiently characterized. This study evaluated toxicological, behavioral, and morphometric endpoints in B. splendens to provide an integrated assessment of the impacts of MT exposure. Immersion assays in fry (2 days post- hatch, dph) demonstrated clear dose- and exposure-dependent toxicity, with cumulative toxicity under continuous 48 h immersion while greater tolerance under discrete immersion (two 3 h immersion at 2 …

Use Of Telehealth For Measurement Of Anthropometrics In Toddlers And Their Parents, Sarah S Farabi, Cindy Schwarz, Bria Lee-Robinson, Lauren G Fiechtner, Victor Davila-Roman, Rachel G Tabak, Debra Haire-Joshu

2020-Current year OA Pubs

INTRODUCTION: The use of telehealth (e.g., live video calling) to collect anthropometric data in toddlers and their parents to increase participation in lifestyle interventions holds promise. But, there is limited evidence to support reliability of telehealth for the collection of these measures. This study aimed to determine the reliability of use of telehealth with parents to collect anthropometric and blood pressure measures on themselves and anthropometric measures on their toddler and determine the acceptability of instruction.

METHODS: This cross-sectional study was conducted as part of the developmental phase of a larger study. Research staff instructed parents via video call to …

A Multicenter Study To Assess Efficacy, Safety, And Tolerability Of Ropeginterferon Alfa-2b-Njft In Patients With Essential Thrombocythemia In The Us And Canada: Exceed-Et Trial, Lucia Masarova, Stephen T Oh, Et Al.

2020-Current year OA Pubs

No abstract provided.

Case Report: Molecular Characterization Of Adult Atypical Teratoid Rhabdoid Tumor And Review Of The Literature, Miguel A Hernandez-Rovira, Michelle Connor, Robert C Osorio, Emilie Russler-Germain, Robert Schmidt, Gabrielle W Johnson, Julie Silverstein, Sonika Dahiya, Nyssa Fox Farrell, Mia C Weiss, Gregory J Zipfel, Jiayi Huang, Dimitrios Mathios

2020-Current year OA Pubs

BACKGROUND AND IMPORTANCE: Atypical teratoid rhabdoid tumors (ATRTs) are typically aggressive pediatric tumors with a median survival of 11 months. Due to the paucity of cases in adults, the clinical behavior of these pathologies is not well understood. Here we present the case of a 41-year-old female patient with postoperative hyperprogression of a sellar ATRT and provide a detailed description of the molecular composition of this tumor, the protocol used to treat this patient, and the ultimate outcome of this patient.

CLINICAL PRESENTATION: The patient is a 41-year-old woman who presented with headaches and double vision. MRI revealed a sellar/suprasellar …

Integrating Mapk Pathway Inhibition Into Standard-Of-Care Therapy For Pediatric Low-Grade Glioma, Erin E Crotty, Aimee A Sato, Mohamed S Abdelbaki

2020-Current year OA Pubs

Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. Recent biologic insights and therapeutic targeting of MAPK-alterations have dramatically shifted the treatment approach in pLGG. While chemotherapy remains front-line therapy for unresectable pLGG in most scenarios (with the notable exception of

Identification Of Candidate Cardiomyopathy Modifier Genes Through Genome Sequencing And Rna Profiling, Malene E Lindholm, Gerald W Dorn, Et Al.

2020-Current year OA Pubs

BACKGROUND: Phenotypic heterogeneity is apparent among individuals with putative monogenic disease, such as familial hypertrophic cardiomyopathy. Genome sequencing (GS) allows interrogation of the full spectrum of inborn genetic variation in an individual and RNA profiling provides a snapshot of the cardiac-specific pathogenic effects on gene expression.

OBJECTIVES: Identify candidate genetic modifiers of hypertrophic cardiomyopathy phenotype.

METHODS: We performed GS of 48 individuals with variants in

RESULTS: GS identified the

CONCLUSION: Evaluation of the whole genome, even in the case of alleged monogenic disease, leads to important new insights. The identified variants, regions, and genes are candidates to modify disease presentation …

Sensorimotor Faculties Bias Choice Behavior, Jan Kubanek, Lawrence H Snyder, Richard A Abrams

2020-Current year OA Pubs

Decision-making is a deliberate process that seemingly evolves under our own volition. Yet, research on embodied cognition has demonstrated that higher-order cognitive processes may be influenced, in unexpected ways, by properties of motor and sensory systems. Here we tested whether and how decisions are influenced by handedness and by asymmetries in the auditory system. Right- and left- handed participants performed an auditory decision task. In the task, subjects decided whether they heard more click sounds in the right ear or in the left ear, and pressed a key with either their right or left index finger, according to an instructed …

Case Report: Rosah Syndrome Presents Diagnostic And Therapeutic Challenges, Jenny Shunyakova, Margaret Reynolds, Amal Taylor, Erin G Sieck, James T Walsh, Lynn M Hassman

2020-Current year OA Pubs

BACKGROUND: Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache (ROSAH) syndrome is an autosomal dominant disorder caused by a heterozygous missense mutation in alpha kinase 1 (ALPK1). This series reports the presentation and treatment outcomes of three first-degree relatives with ROSAH syndrome.

METHODS: Retrospective chart review, whole exome sequencing.

RESULTS: A 16-year-old male presented with bilateral optic disc edema, macular edema, retinal degeneration, and vitreous inflammation. His mother and brother had similar clinical features. Whole exome gene sequencing identified a shared heterozygous mutation in the ALPK1 gene c.710C>T, consistent with ROSAH syndrome. Ophthalmic manifestations in this family included …

Defining Knowledge Gaps In Preterm Birth Research: Can Biomarkers Fill The Gaps?, Scott M Williams, Kevin P Rosenblatt, Sandra Reznik, Dawn P Misra, Shajila Siricilla, Nardhy Gomez-Lopez, Brandie D Taylor, Kristina M Adams Waldorf, Ramkumar Menon, Prebic North America 2024

2020-Current year OA Pubs

Preterm birth (PTB) is a syndrome arising from multiple etiologies that manifest as a final common phenotype, delivery before full term. Current knowledge gaps in epidemiologic, basic science, and clinical fields have limited our understanding of this complex pregnancy syndrome. Lack of insight into the cellular and molecular pathways underlying spontaneous PTB (PTB) has thus limited effective clinical management and restricted the investigation of novel treatments or druggable targets. Here, we examine several areas of domain-driven research that may lead to a better understanding of PTB, including infection and inflammation that drive early labor, social factors and their biological consequences …

Mechanisms And Environmental Factors Shaping The Ecosystem Of Brain Macrophages, Silvia Penati, Simone Brioschi, Zhangying Cai, Claudia Z Han, Marco Colonna

2020-Current year OA Pubs

Brain macrophages encompass two major populations: microglia in the parenchyma and border-associated macrophages (BAMs) in the extra-parenchymal compartments. These cells play crucial roles in maintaining brain homeostasis and immune surveillance. Microglia and BAMs are phenotypically and epigenetically distinct and exhibit highly specialized functions tailored to their environmental niches. Intriguingly, recent studies have shown that both microglia and BAMs originate from the same myeloid progenitor during yolk sac hematopoiesis, but their developmental fates diverge within the brain. Several works have partially unveiled the mechanisms orchestrating the development of microglia and BAMs in both mice and humans; however, many questions remain unanswered. …

Multidisciplinary Approach To Treating Complex Immune Dysregulation Disorders: An Adaptive Model For Institutional Implementation, Lauren A Henderson, Megan A Cooper, Anthony French, Et Al.

2020-Current year OA Pubs

Patients with immune dysregulation may present with varying combinations of autoimmunity, autoinflammation, immunodeficiency, atopy, lymphoproliferation, and/or malignancy, often with multisystem involvement. Recognizing specific patterns of immune dysregulation, coordinating and interpreting complex diagnostic testing, and choosing initial (often empiric) treatment can be challenging. Centers are increasingly assembling multidisciplinary teams (MDTs) to standardize evaluation and optimize treatment of patients with complex immune dysregulation (immune dysregulation MDTs [immMDTs]). However, published information on the composition and function of immMDTs is sparse, and there is little guidance for those seeking to establish or optimize an immMDT. To inform this review, we assembled a panel of …

The Evolution And Application Of Multi-Omic Analysis For Pituitary Neuroendocrine Tumors, Sangami Pugazenthi, Shree S Pari, Ziyan Zhang, Julie Silverstein, Albert H Kim, Bhuvic Patel

2020-Current year OA Pubs

Pituitary neuroendocrine tumors (PitNETs) are a heterogeneous group of intracranial neoplasms that vary in hormonal activity, histological features, and clinical behavior. The rise of high-throughput sequencing and molecular profiling technologies has enabled multiomic approaches-including genomics, transcriptomics, epigenomics, proteomics, and metabolomics-to deepen our understanding of PitNET pathogenesis. These studies have identified key mutations, transcriptional lineages, epigenetic modifications, and proteomic features that contribute to tumor subtype classification, invasiveness, and treatment response. Integrative multi-omic analyses have further revealed distinct molecular subtypes, complex regulatory networks, and molecular profiles that can predict recurrence and therapeutic efficacy. These approaches hold strong potential for advancing personalized medicine …

The Role Of Complement In Normal Pregnancy And Preeclampsia, Richard M Burwick, Anuja Java, Jean F Regal

2020-Current year OA Pubs

Preeclampsia affects 3-4% of pregnancies with adverse effects for both mother and child. Minimal therapeutic options are available, and biomarkers are urgently needed to identify those at greatest risk early in the pregnancy. Both the innate and adaptive immune systems are well regulated during normal pregnancy including the complement system. A functioning complement system with some degree of complement activation participates in proper placental development, ensuring a healthy pregnancy and assisting with host defense. However, aberrant complement activation can lead to adverse pregnancy outcomes such as preeclampsia. An overview of the complement system will be presented, along with review of …