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2025

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Shooting For The Stars: The Place Of International Economic Law In The International Legal Order, Valentina Vadi Jan 2025

Shooting For The Stars: The Place Of International Economic Law In The International Legal Order, Valentina Vadi

Indian Journal of International Economic Law

In the universe of international law, the galaxy of international economic law (IEL) consists of various legal instruments, institutions, and experts that – like stars, planets, and vast clouds of dust – are all bound together by gravity. Like cosmonauts, international economic courts ‘must look for reliable reference points in the known legal cosmology.’2 This article aims to contextualise the galaxy of international economic law within the universe of international law, discuss its role within the same, and identify some reference points that can help adjudicators navigate by the stars.


Comparison Of Treatment Outcome Of Occlusal Splints And Physiotherapy Regarding Their Effect On Posture: An In Vivo Pilot Study, Bouchra El Fassih, Amine El Zoghbi, Pascal El Braidy Jan 2025

Comparison Of Treatment Outcome Of Occlusal Splints And Physiotherapy Regarding Their Effect On Posture: An In Vivo Pilot Study, Bouchra El Fassih, Amine El Zoghbi, Pascal El Braidy

International Arab Journal of Dentistry

Objectives: The primary objective of the research is to assess occlusal splints and physical exercise effect on posture. The secondary objective is to compare which treatment option has more positive feedback regarding posture adjustment.

Methods: twenty patients with temporomandibular disorders (TMD) were divided into two groups equally, one receiving occlusal splints as a treatment for TMD and the other group receiving physical therapy exercises. They underwent a clinical and postural examination at baseline, after 1 week, after 1 month and after 2 months of treatment. Postural stability was assessed using a force platform (SATEL). Subjects were evaluated in …


The Impact Of Smoking Cessation On Clinical Outcomes Of Stage I/Stage Ii, Grade A/Grade B Periodontitis Patients In Periodontal Maintenance Phase: A 2-Year Longitudinal Study, Santosh R Patil, Shikhar Daniel, Aysha Jebin A Jan 2025

The Impact Of Smoking Cessation On Clinical Outcomes Of Stage I/Stage Ii, Grade A/Grade B Periodontitis Patients In Periodontal Maintenance Phase: A 2-Year Longitudinal Study, Santosh R Patil, Shikhar Daniel, Aysha Jebin A

International Arab Journal of Dentistry

Objectives: The objective of this study is to investigate the influence of smoking cessation interventions on periodontal outcomes in individuals who have successfully abstained from smoking for a minimum of six months following non-surgical periodontal therapy.

Methods: A total of 122 participants, based on inclusion & exclusion criteria, were divided into a smoking cessation group (n=61) and a control group (n=61). Demographic characteristics, smoking history, and baseline oral health parameters were assessed in these patients. Over a 2-year follow-up period, changes in probing depth and alveolar bone loss were measured, statistically analysis were performed using SPSS software.

Results …


Effect Of Adaptation Time On Retention Of Maxillary 3d-Printed Denture Versus Conventional Heat-Cured Acrylic Denture: A Randomized Controlled Trial, Ahmed Hebeshi, Moataz Elmahdy, Sayed Elmasry, Hala Abdelhameed Jan 2025

Effect Of Adaptation Time On Retention Of Maxillary 3d-Printed Denture Versus Conventional Heat-Cured Acrylic Denture: A Randomized Controlled Trial, Ahmed Hebeshi, Moataz Elmahdy, Sayed Elmasry, Hala Abdelhameed

International Arab Journal of Dentistry

Objectives: The study aimed to investigate the effect of adaptation time on the retention of 3d printed versus conventional heat-cured acrylic maxillary complete dentures.

Methods: 20 patients were distributed into: Group A received ten conventional complete heatcured acrylic dentures and Group B received ten printed complete dentures. Denture retention was measured at 0, 1 , and 3 months.

Results: For acrylic denture and printed denture groups, Mean values in denture retention increased with time but this increase was statistically non-significant. The change in denture retention over time (difference in retention between the third month and at the …


Three-Dimensional Analysis Of Dental Arch Form In Relation To The Vertical Facial Pattern In Class I Patients: A Cross-Sectional Study, Ahmad Ghassan Droubi, Islam Gad, Aly Osman Jan 2025

Three-Dimensional Analysis Of Dental Arch Form In Relation To The Vertical Facial Pattern In Class I Patients: A Cross-Sectional Study, Ahmad Ghassan Droubi, Islam Gad, Aly Osman

International Arab Journal of Dentistry

Introduction: Understanding the relationship between dental arch form and vertical facial pattern is crucial in orthodontic diagnosis and treatment planning. Variations in vertical facial morphology can influence dental arch form, which in turn impacts the effectiveness and stability of orthodontic interventions.

Objectives: The study explores the associations between dental arch form with the different vertical facial patterns, including hyperdivergent, normodivergent, and hypodivergent patterns in skeletal Class I patients.

Methods: A cross-sectional observational design was employed to examine a sample of 48 patients with skeletal Class I seeking orthodontic treatment; of which 24 males and 24 females. Each …


A Two-Stage Radiographic Study Of The Prevalence Of Anomalies Associated With Tooth Number, Vellore Kannan Gopinath, Diaa Elderini, Reem Salama, Sangeetha Narasimhan, Vinayak Kamath, Shishir Shetty Jan 2025

A Two-Stage Radiographic Study Of The Prevalence Of Anomalies Associated With Tooth Number, Vellore Kannan Gopinath, Diaa Elderini, Reem Salama, Sangeetha Narasimhan, Vinayak Kamath, Shishir Shetty

International Arab Journal of Dentistry

Introduction: Dental anomalies (DA) are a group of dental developmental disturbances which appear during tooth formation manifesting themselves as an alteration in tooth number, shape, and size. Dental anomalies of number include hypodontia, mesiodens, supernumerary tooth, and odontoma.

Objectives: To evaluate the prevalence and distribution of dental anomalies associated with tooth number in the radiographic archives of University Dental Hospital Sharjah, United Arab Emirates (UAE).

Methods: Retrospective evaluation of 2000 Orthopantomogram (OPG) images were taken between January 2015 to December 2022. The OPG showing dental anomalies of number were further investigated for the availability of Cone Beam …


Evaluation Of The Effect Of 3 Bonding Protocols On The Micro-Tensile Bond Strength Of Self-Adhesive Composite To Enamel And Dentin, Mohamad Yaman, Louis Hardan, George Najjar, Cynthia Kassis Jan 2025

Evaluation Of The Effect Of 3 Bonding Protocols On The Micro-Tensile Bond Strength Of Self-Adhesive Composite To Enamel And Dentin, Mohamad Yaman, Louis Hardan, George Najjar, Cynthia Kassis

International Arab Journal of Dentistry

Objectives: To investigate the micro tensile bond strength (µTBS) of self-adhesive bulk-fill composite (Surefil One) to enamel and dentin bonded without bonding agent, with an additional phosphoric acid etch, and with the use of a bonding agent in etch and rinse mode.

Methods: 90 sound extracted wisdom teeth were used in this study. Surefil One (Dentsply Sirona, Konstanz, Germany), Prime&Bond Universal (Dentsply Sirona, Konstanz, Germany) and Detrey Conditioner 36 Etch Gel (Dentsply Sirona, Konstanz, Germany) were tested. Teeth were divided in 6 groups of 15 teeth, according to tooth substrate (enamel and dentin) and bonding protocols (no bonding …


Color Stability Of Conventional, 3d-Printed, And Milled Denture Teeth After Immersion In Coloring Agents: An In Vitro Study, Dany Nassif, Nancy Chemaly, Rim Bourgi, Carole Abi-Ghosn, Louis Hardan, Jihad Fakhouri Jan 2025

Color Stability Of Conventional, 3d-Printed, And Milled Denture Teeth After Immersion In Coloring Agents: An In Vitro Study, Dany Nassif, Nancy Chemaly, Rim Bourgi, Carole Abi-Ghosn, Louis Hardan, Jihad Fakhouri

International Arab Journal of Dentistry

Objectives: This study investigates the color stability of denture teeth made from different materials when subjected to various staining solutions.

Methods: Forty-five A1 shade upper central incisors were divided into three groups: prefabricated, 3D printed, and milled denture teeth (N=45). Each group was further divided into three subgroups, with teeth immersed in coffee, wine, and artificial saliva for up to 120 days (n=5). ∆E values for color change were measured using an Optishade colorimeter.

Results: The type of teeth, type of solution, and immersion time had a significant effect on color stability (p < 0.001). Interactions between the three variables were all significant (p < 0.001). Conventional denture teeth showed slight color changes with saliva (ΔE = 1.256 by day 120), moderate changes with wine (ΔE = 2.893), and more significant changes with coffee (ΔE = 5.208). Milled denture teeth exhibited no color changes with saliva, noticeable changes with wine (ΔE = 5.359), and moderate changes with coffee (ΔE = 3.137). 3D printed denture teeth showed no color changes with saliva, but increased changes with wine (ΔE = 2.533) and highly significant changes with coffee (ΔE = 10.546). Coffee consistently caused the highest ΔE values, especially in 3D printed teeth.

Conclusions: The study …


Surgical Symphony: Tackling Large Periapical Cysts With Precision, Paridhi Agrawal, Manoj Chandak, Pooja Agrawal, Nitin Bhola, Rajnikant Kambala, Samiha Khan, Aayushi Pakhale, Jay Bhopatkar, Tejas Suryawanshi, Palak Hirani Jan 2025

Surgical Symphony: Tackling Large Periapical Cysts With Precision, Paridhi Agrawal, Manoj Chandak, Pooja Agrawal, Nitin Bhola, Rajnikant Kambala, Samiha Khan, Aayushi Pakhale, Jay Bhopatkar, Tejas Suryawanshi, Palak Hirani

International Arab Journal of Dentistry

This case report details the comprehensive treatment of a large radicular cyst in a 48-yearold male with a five-year history of swelling and pus discharge in the upper anterior jaw. Clinical and radiographic examinations, including CBCT, revealed a significant periapical lesion involving multiple teeth. The multidimensional treatment began with meticulous endodontic therapy for teeth 12, 11, 21, and 22, followed by Platelet-rich fibrin (PRF) application to enhance healing. Surgical cystic enucleation was performed under local anesthesia, involving flap elevation and cyst removal, confirmed by biopsy as a radicular cyst. Apicoectomy and retrograde filling with mineral trioxide aggregate (MTA) were executed. …


Patient-Related And Tooth-Related Factors As Predictors For Tooth Loss In Periodontitis Patients: A Systematic Review, Cleane Daraze, Carole Chakar, Abdelrahman Kassir, Charbel Anka, Jean-Marie Megarbane Jan 2025

Patient-Related And Tooth-Related Factors As Predictors For Tooth Loss In Periodontitis Patients: A Systematic Review, Cleane Daraze, Carole Chakar, Abdelrahman Kassir, Charbel Anka, Jean-Marie Megarbane

International Arab Journal of Dentistry

Introduction: The treatment of periodontitis aims to prevent further disease progression, to minimize symptoms and perception of the disease, possibly to restore lost tissues and to support patients in maintaining a healthy periodontium. Management of chronic periodontal disease requires a combination of therapeutic modalities and a lifelong commitment to periodontal self-care.

Objectives: The aim of this study is to evaluate predictors for tooth loss in patients previously diagnosed with periodontitis. This systematic review covers studies of over 10 years of follow up.

Methods: Electronic literature search was conducted on 19/02/2024 by one author across several databases, including …


Sustainable Hospitals Lighting Design Optimization To Enhance Patient Well-Being, Merna R. Ashac, Rania F. Ismail, Nasreen Fathy Abdelsalam Jan 2025

Sustainable Hospitals Lighting Design Optimization To Enhance Patient Well-Being, Merna R. Ashac, Rania F. Ismail, Nasreen Fathy Abdelsalam

Mansoura Engineering Journal

This research investigates the critical role of lighting design in hospitals environments, focusing on its impact on patient outcomes and environmental sustainability. By integrating energy-efficient LEDs and natural light, the study aims to enhance patient well-being and staff performance. To achieve this, the research explores aligning artificial lighting with circadian rhythms to improve both patient outcomes and staff performance. Using mixed-methods approach, the research includes a literature review, case studies, and analysis using DIALux simulation software. The literature review achieves a framework for sustainable, human-centric lighting, while case studies provide practical insights into effective designs in patient rooms. DIALux simulations …


Evaluating Machine Learning Techniques For Breast Cancer Detection: A Comprehensive Review, Owen Kresse, Youssef Kamel Kamel Hassan Rezk, Alaaelddin Ibrahim Said, Rana Hossameldin Mousa, Merna Adel Abdelrahman Ibrahim, Ahmed Fathy Sweed, Tomas Pegorari, Pablo Nakasato, Ainhoa Osa-Sanchez, Itxasne Del Barrio, Francesc Serra Crespí, Keltse Santisteban Ortiz, Naiara Melián Eguia, Mohamed Elsharkawy, Ibrahim Abdelhalim, Begonya Garcia-Zapirain, Ayman El-Baz Jan 2025

Evaluating Machine Learning Techniques For Breast Cancer Detection: A Comprehensive Review, Owen Kresse, Youssef Kamel Kamel Hassan Rezk, Alaaelddin Ibrahim Said, Rana Hossameldin Mousa, Merna Adel Abdelrahman Ibrahim, Ahmed Fathy Sweed, Tomas Pegorari, Pablo Nakasato, Ainhoa Osa-Sanchez, Itxasne Del Barrio, Francesc Serra Crespí, Keltse Santisteban Ortiz, Naiara Melián Eguia, Mohamed Elsharkawy, Ibrahim Abdelhalim, Begonya Garcia-Zapirain, Ayman El-Baz

Mansoura Engineering Journal

Breast cancer is considered one of the most common types of cancer among women. significant amount of effort done in early detection to increase survival chance since early detection is a challenging task especially in certain breast cancer conditions or using inefficient imaging modalities AI demonstrated significant potential in breast cancer detection algorithms including convolutional neural networks (CNNs) and Transformers, which have achieved highly accurate results but they have some limitations, such as the large amounts of data required for training as CNNs rely on local features, while Transformers focus on global features However, recent research has proposed hybrid models …


Photocatalytic Production Of Hydrogen From Sodium Borohydride Using Tio2/Mwcnt, Ahmed S . Sewerky, Ibrahim Gar Al Alm Rashed, M.M. El-Halwany, Mohamed R. Elmarghany Jan 2025

Photocatalytic Production Of Hydrogen From Sodium Borohydride Using Tio2/Mwcnt, Ahmed S . Sewerky, Ibrahim Gar Al Alm Rashed, M.M. El-Halwany, Mohamed R. Elmarghany

Mansoura Engineering Journal

In this research, a novel photocatalyst composed of titanium dioxide TiO2 supported on multi-walled carbon nanotubes (MWCNTs) was synthesized using the sol-gel method to produce hydrogen H2 from the hydrolysis of sodium borohydride NaBH4. The TiO2/MWCNT composite’s photocatalytic activity was examined under ultraviolet (UV) light irradiation, with UV lamps used as the source. The experiments were repeated at different temperatures and varying catalyst doses to analyze their effects on H2 generation. The synthesized photocatalyst was characterized through structural, morphological, and compositional studies using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (EDX). The findings reveal that …


A Multi-Variate Rotating Machinery Fault Optimization And Recognition Framework, Ahmed M. Abdelrahman, Amira Y. Haikal, Mahmoud M. Saafan Jan 2025

A Multi-Variate Rotating Machinery Fault Optimization And Recognition Framework, Ahmed M. Abdelrahman, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Accurate diagnosis, prognosis, and forecasting of a machine's time-to-failure are crucial through the massive, profound monitoring parameters and expeditiously is essential to assist in the preservation of reliability and life remaining for the machine increase by recommending an appropriate decision to diminish the occurrence of ruinous malfunction and substantial financial losses proactively. Artificial intelligence is considered significantly crucial to specialists in diagnosing various faults. But all research, although have great accuracy, still till now have a lack on the number of considering parameters to achieve the diagnosis or prognosis.in addition to, it depends on repeat the processing for sensor reading …


Real-Time Intelligent Parking Management In Smart Cities Using Internet Of Things, Genetic Algorithms, And Machine Learning, Mohammed Abo-Zahhad, Mohammed M. Abo-Zahhad Jan 2025

Real-Time Intelligent Parking Management In Smart Cities Using Internet Of Things, Genetic Algorithms, And Machine Learning, Mohammed Abo-Zahhad, Mohammed M. Abo-Zahhad

Mansoura Engineering Journal

Smart city parking systems face significant challenges related to real-time availability updates, security vulnerabilities in RFID-based access, and connectivity issues. To address these limitations, this paper proposes a comprehensive two-stage intelligent parking system that integrates Internet of Things (IoT), Genetic Algorithms (GAs), and Machine Learning (ML) techniques. The system utilizes sensor technologies, such as infrared sensors and ESP8266 controllers, combined with a mobile application to monitor and manage parking space occupancy in real-time efficiently. In the first stage, real-time parking availability is detected through sensor data transmitted to a cloud infrastructure that updates the user interfaces. The second stage employs …


Small And Mighty: Student Affairs At Small Colleges And Universities, Stacy Fisher Jan 2025

Small And Mighty: Student Affairs At Small Colleges And Universities, Stacy Fisher

Journal of Higher Education & Student Affairs

Book Review


Beyond The Glass Ceiling: Career Advancement Strategies For Mid-Level Women In Student Affairs, Jalonda N. Thompson Jan 2025

Beyond The Glass Ceiling: Career Advancement Strategies For Mid-Level Women In Student Affairs, Jalonda N. Thompson

Journal of Higher Education & Student Affairs

The purpose of this paper is to provide an overview of the literature on the push and pull factors that influence women’s choices to either opt in or opt out of career advancement in student affairs (Coetzee & Moosa, 2020; Harman & Sealy, 2017). Women, specifically Black women, are underrepresented in Senior Student Affairs Officer (SSAO) positions in higher education (American Council of Education, 2024). As the demographics of the United States (US) change, student affairs is at a critical point to foster an inclusive learning environment that reflects the increasing racial and ethnic diversity in the US (Lopez, 2006). …


Mortality Prediction After Major Surgery In A Mixed Population Through Machine Learning: A Multi-Objective Symbolic Regression Approach, Pietro Arina, Davide Ferrari, Nicholas Tetlow, Amy Dewar, Robert Stephens, Daniel Martin, Ramani Moonesinghe, Vasa Curcin, Mervyn Singer, John Whittle, Evangelos B Mazomenos Jan 2025

Mortality Prediction After Major Surgery In A Mixed Population Through Machine Learning: A Multi-Objective Symbolic Regression Approach, Pietro Arina, Davide Ferrari, Nicholas Tetlow, Amy Dewar, Robert Stephens, Daniel Martin, Ramani Moonesinghe, Vasa Curcin, Mervyn Singer, John Whittle, Evangelos B Mazomenos

Peninsula Medical School

INTRODUCTION: Understanding 1-year mortality following major surgery offers valuable insights into patient outcomes and the quality of peri-operative care. Few models exist that predict 1-year mortality accurately. This study aimed to develop a predictive model for 1-year mortality in patients undergoing complex non-cardiac surgery using a novel machine-learning technique called multi-objective symbolic regression.

METHODS: A single-institution database of patients undergoing major elective surgery with previous cardiopulmonary exercise testing was divided into three datasets: pre-operative clinical data; cardiorespiratory and physiological data; and combined. A multi-objective symbolic regression model was developed and compared against existing models. Model performance was evaluated using the …


Serious Games For Constipation Management For People With Intellectual Disabilities: A Scoping Review And Narrative Synthesis, Serena Daniel, Ruth Bishop, Ellie Killner, Alison Whight, Sarah Lennard, Stephen Howard, Richard Laugharne, Rohit Shankar Jan 2025

Serious Games For Constipation Management For People With Intellectual Disabilities: A Scoping Review And Narrative Synthesis, Serena Daniel, Ruth Bishop, Ellie Killner, Alison Whight, Sarah Lennard, Stephen Howard, Richard Laugharne, Rohit Shankar

Peninsula Medical School

Introduction: People with intellectual disability (PwID) are 2% of the UK population. Constipation and bowel movement (BM) problems (diarrhoea/faecal incontinence etc.) affects over a third of PwID and is a serious cause of morbidity and mortality. Pw ID rely heavily on outside support (family/professional carers/healthcare professionals), many of whom are ignorant to bowel related harms. There is significant stigma to discuss BM particularly constipation. Serious Games (SG) are increasingly used for education of health needs. This review examines if game-based technology can assist improving knowledge and reducing stigma of BM problems particularly constipation. Objective: To identify and gain evidence of …


Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale Jan 2025

Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale

Peninsula Medical School

Introduction: There is evidence of an association between tolerance of ambiguity and psychological wellbeing in doctors, but this relationship is not well understood. We explored this relationship, and the individual or workplace factors moderating it, in a population of newly qualified doctors. Methods: We examined the experiences of newly qualified doctors in the UK as they started a novel interim role (Time 1) and later moved into foundation year 1 roles (Times 2 and 3) during the COVID-19 pandemic. Doctors completed the Tolerance of Ambiguity of Medical Students and Doctors scale (TAMSAD Range: 0–100), the Perceived Stress Scale (PSS: 0–40), …


Patterns Of Intra-Cluster Correlation Coefficients In School-Based Cluster Randomised Controlled Trials Of Interventions For Improving Social-Emotional Functioning Outcomes In Pupils: A Secondary Data Analysis Of Five Uk-Based Studies, Kitty Parker, Michael Nunns, Zhi Min Xiao, Tamsin Ford, Paul Stallard, Willem Kuyken, Nick Axford, Obioha C. Ukoumunne Jan 2025

Patterns Of Intra-Cluster Correlation Coefficients In School-Based Cluster Randomised Controlled Trials Of Interventions For Improving Social-Emotional Functioning Outcomes In Pupils: A Secondary Data Analysis Of Five Uk-Based Studies, Kitty Parker, Michael Nunns, Zhi Min Xiao, Tamsin Ford, Paul Stallard, Willem Kuyken, Nick Axford, Obioha C. Ukoumunne

Peninsula Medical School

Background: The cluster randomised trial (CRT) design is increasingly used to evaluate the impact of school-based interventions for improving social-emotional functioning outcomes in pupils. Good knowledge is required on plausible values of the intra-cluster correlation coefficient (ICC) of the outcome to calculate the required sample size in such studies. Using data from five school-based CRTs in the UK, we estimate, and describe patterns in, ICCs for social-emotional functioning outcomes. Methods: Mixed effects linear regression models were fitted to estimate the ICC and variance components. Estimates for baseline data were obtained by fitting “null” models that had no predictor variables; estimates …


Epidemiology Of Thrombotic Thrombocytopenia Syndrome 2011 To 2022: English Sentinel Network Cohort Studies, José M. Ordóñez-Mena, Debasish Kar, Xuejuan Fan, Filipa Ferreira, Sneha N. Anand, Deborah Layton, David Clifton, Mark Joy, Anshul Thakur, Anu Alessi, Andrew Lee, Lisa Mather, Simon De Lusignan Jan 2025

Epidemiology Of Thrombotic Thrombocytopenia Syndrome 2011 To 2022: English Sentinel Network Cohort Studies, José M. Ordóñez-Mena, Debasish Kar, Xuejuan Fan, Filipa Ferreira, Sneha N. Anand, Deborah Layton, David Clifton, Mark Joy, Anshul Thakur, Anu Alessi, Andrew Lee, Lisa Mather, Simon De Lusignan

Peninsula Medical School

Background and Objective: Thrombotic thrombocytopenia syndrome (TTS) is a rare condition following vaccination with adenovirus-vectored coronavirus disease 2019 (COVID-19) vaccines. This retrospective analysis of England primary care data aimed to estimate TTS event rates before, during, and after the COVID-19 pandemic, and following AZD1222 (ChAdOx1-nCoV-19) vaccination. Methods: Primary care data on TTS events were collected using the Oxford-Royal College of General Practitioners Research and Surveillance Centre sentinel network. TTS events were defined as thromboembolism with coincident (± 7 days) thrombocytopenia events using Systematized Nomenclature of Medicine clinical terms (the current Brighton Collaboration definition could not be used in the study …


Il-1 Signal Inhibition In Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial Of Canakinumab, Nikhil Vergis, Vishal Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Thomas Tranah, Mary Cross, Daphne Babalis, Neil Foster, Emma Lord, Alberto Quaglia, Josephine Lloyd, Robert Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagan, David Patch, Nikolai Naoumov, Ashwin Dhanda, Ewan Forrest, Mark Thursz Jan 2025

Il-1 Signal Inhibition In Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial Of Canakinumab, Nikhil Vergis, Vishal Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Thomas Tranah, Mary Cross, Daphne Babalis, Neil Foster, Emma Lord, Alberto Quaglia, Josephine Lloyd, Robert Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagan, David Patch, Nikolai Naoumov, Ashwin Dhanda, Ewan Forrest, Mark Thursz

Peninsula Medical School

Background and Aims: Short-term mortality in alcohol-related hepatitis (AH) is high, and no current therapy results in durable benefit. A role for interleukin (IL)-1β has been demonstrated in the pathogenesis of alcohol-induced steatohepatitis. This study explored the safety and efficacy of canakinumab (CAN), a monoclonal antibody targeting IL-1β, in the treatment of patients with AH. Methods: Participants with biopsy-confirmed AH and discriminant function ≥32 but Model for End-Stage Liver Disease ≤27 were randomly allocated 1:1 to receive either CAN 3 mg/kg or placebo (PBO). Liver biopsies were taken before and 28 days after treatment. The primary endpoint was the overall …


Trait Mindfulness And Parenting Stress: Predicting Parenting Behavior In Families Of Autistic Preschoolers, Elliot Hess Jan 2025

Trait Mindfulness And Parenting Stress: Predicting Parenting Behavior In Families Of Autistic Preschoolers, Elliot Hess

CMC Senior Theses

Parents of autistic preschoolers often report high levels of stress that spill over into daily parenting. Mindfulness is promoted in clinical settings as a protective factor, yet its real-world role for stressed caregivers remains unclear. We used baseline data from 112 caregivers of autistic preschoolers participating in a stress-reduction clinical trial to examine whether trait mindfulness alters the link between parenting stress and parenting behavior. Parents reported on their own parenting stress, trait mindfulness, and parenting behavior as part of a broader pre-intervention assessment. Moderation effects were analyzed using hierarchical regression, with follow-up analysis of simple slopes and regions of …


Determinants Of Remote Suitability Of Jobs And Residential Distance From The Workplace After The Covid-19 Pandemic, Abizer Mamnoon Jan 2025

Determinants Of Remote Suitability Of Jobs And Residential Distance From The Workplace After The Covid-19 Pandemic, Abizer Mamnoon

CMC Senior Theses

Immediately before the COVID-19 pandemic, workers performed 14% of their paid hours from home, but this figure increased to 38% after the pandemic (Chen et al. 2023). This thesis contributes to our understanding of the determinants of remote work and the factors affecting how far an individual lives from the workplace in the post-pandemic period.

I use 1.95 million observations of worker-specific LinkedIn data from August 2023. I construct a measure of remote suitability using Dingel and Neiman’s (2020) method to assign each job title a remote suitability score based on the associated occupation. I use a Tobit regression to …


Beginner's Luck: The Impact Of Early Wins On Long-Term Gambling Patterns, Jasmine Tan Jan 2025

Beginner's Luck: The Impact Of Early Wins On Long-Term Gambling Patterns, Jasmine Tan

CMC Senior Theses

The legalization of online sports gambling has rapidly expanded access to gambling platforms, raising concerns about its potential impacts on gambling behavior and addiction. This study investigates whether early wins in online sports gambling predict sustained gambling engagement. Using longitudinal data from 46,339 subscribers to online gambling site bwin Entertainment, we analyzed the gambling activity of new sports bettors over 18 months. Gamblers were categorized based on early outcomes (losses, break-even, small wins, and big wins), and engagement was measured by total bets placed, total gambling days, total stakes after the first three days, and frequency of play. Interaction terms …


The Interplay Of Gender And Humor In The Workplace, Charlene Marie Baghdadi Jan 2025

The Interplay Of Gender And Humor In The Workplace, Charlene Marie Baghdadi

CMC Senior Theses

Humor is a key element in workplace dynamics, influencing leadership, team cohesion, and career advancement. However, its impact is not equal among genders. This paper explores the interplay between humor and gender in professional settings, examining how different types of humor – positive (affiliative, self-enhancing, coping sense of humor) and negative (aggressive, self-defeating) – are perceived and used by men and women. Specifically, it investigates how gender and team composition moderate the relationship between types of humor and workplace outcomes, with gender stereotypes acting as a mediator. This analysis highlights that men often benefit from a broader acceptance of humor …


Assessing The Impact Of Medicaid Expansion On The Labor Market, Healthcare Access, And Health Outcomes During The Covid-19 Pandemic, Kaavya Narayan Jan 2025

Assessing The Impact Of Medicaid Expansion On The Labor Market, Healthcare Access, And Health Outcomes During The Covid-19 Pandemic, Kaavya Narayan

CMC Senior Theses

This thesis examines the impact of Medicaid expansion status on labor market outcomes, healthcare access, and health outcomes during COVID-19. Using data from the CDC’s Behavioral Risk Factor Surveillance System and a Difference-in-Differences (DiD) model, I estimate the effects of Medicaid expansion on unemployment, financial barriers to care, obesity, and poor health before and after the pandemic. The analysis also accounts for state-level political and demographic characteristics, gender, marital status, and education level. My results show that non-expansion states, relative to expansion states of similar political and demographic breakdowns, are significantly more disadvantaged in terms of obesity, poor health, financial …


Equality And Excellence: Providing Quality Opportunities In Women’S Athletics Through Title Ix, Jeissy Lee Jan 2025

Equality And Excellence: Providing Quality Opportunities In Women’S Athletics Through Title Ix, Jeissy Lee

CMC Senior Theses

In 1975, the U.S. codified Title IX amendments to require institutions that receive federal funding to provide both sexes with equal athletic opportunity, an extension of the requirements on non-discrimination in education. While this has helped increase female participation in athletics particularly at the collegiate level, schools engage in four shady practices that can skirt around the intent of Title IX. These include taking advantage of a singular census date, double- or triple-counting athletes, overpacking rosters, and counting male practice players as female athletes. In this paper, I analyze how each of these four practices might improve female athletic opportunities …


A Nation In Decline: Exploring Immigration As A Solution To Japan’S Demographic Crisis, Lindsay Lew Jan 2025

A Nation In Decline: Exploring Immigration As A Solution To Japan’S Demographic Crisis, Lindsay Lew

CMC Senior Theses

This thesis assesses the role of immigration in the economy, particularly as a potential solution to the demographic crisis in Japan. Using data from the United Nations and the World Bank, I conduct a comprehensive panel study of ten countries and regions over the time period spanning 1960 to 2023. My goal is to test the relationship between immigration levels and economic performance, focusing on GDP growth and unemployment rates as key indicators. Regression results reveal that higher net migration rates are associated with modest but statistically significant increases in GDP growth, and measurably significant decreases in unemployment. These findings …