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Articles 751 - 780 of 75572
Full-Text Articles in Entire DC Network
Developing A Vietnamese Text Summarization Large Language Model On Limited Hardware, Tin Pho
Developing A Vietnamese Text Summarization Large Language Model On Limited Hardware, Tin Pho
Master's Theses
Text summarization models have achieved significant growth during the last few years because of major Large Language Model (LLM) technological advancements. The application of LLMs are widely used in news distribution (TL;DR news), translation tools (DeepL Translate), or virtual assistants (ChatGPT, DeepSeek, Claude, etc.). However, the progress has not yet reached all languages equally. The Vietnamese language is used by more than 90 million people, but the language is not as highly developed for LLM as it has many homophones, five different tones that affect meaning of words, and irregular grammar compared to other languages (e.g. English, Spanish, etc.). Also, …
Introduction, Elizabeth G. Clark, Elizabeth Ziemba
Introduction, Elizabeth G. Clark, Elizabeth Ziemba
Visions in Leisure and Business
No abstract provided.
Biomechanics Of The Ribs During Respiration At The Costotransverse Joint: An In-Vivo Retrospective Pilot Study, Michael Maninang, Greg Almeter, Erik Pearson, Arvie Vitente
Biomechanics Of The Ribs During Respiration At The Costotransverse Joint: An In-Vivo Retrospective Pilot Study, Michael Maninang, Greg Almeter, Erik Pearson, Arvie Vitente
Philippine Journal of Physical Therapy
Introduction: Scarce in‑vivo data describe how ribs move at the costotransverse joints during quiet breathing—knowledge critical to thoracic biomechanics and pain mechanisms. This pilot study uses four‑dimensional computed tomography (4D‑CT) to quantify, for the first time, the three‑dimensional magnitude and direction of rib motion at these joints throughout quiet respiration.
Methods: This retrospective, descriptive pilot study analyzed ten 4D‑CT scans obtained from patients undergoing thoracic imaging prior to radiation therapy. End‑expiration and end‑inspiration phases were aligned with a demons deformable‑registration algorithm. For each costotransverse joint, the three‑dimensional displacement vector, its absolute magnitude, and its components along the lateral–medial (L–M), …
Conflicted Assumptions: India's Medical Value Travel Marketing Messages, Irving Stackpole
Conflicted Assumptions: India's Medical Value Travel Marketing Messages, Irving Stackpole
Visions in Leisure and Business
The chronology of the Indian government’s marketing communications rhetoric about medical services exports (commonly referred to as “medical tourism”) from 1990 to 2024 reveals a clear evolution from basic economic liberalization to global leadership positioning. These marketing messages have progressed through distinct phases, consistently emphasizing cost advantages, quality claims, and international competitiveness. It has also become increasingly sophisticated in its use of branding, digital platforms, and systematic promotional frameworks. The evolution from simple "cost advantage" claims to comprehensive "medical hub of the world" positioning demonstrates an evolving promotional narrative, growing ambition, and overestimation of value and demand. This article reviews …
Challenges And Opportunities For India As Well As Wellness Destinations, Michael Wallace
Challenges And Opportunities For India As Well As Wellness Destinations, Michael Wallace
Visions in Leisure and Business
India has emerged as a globally recognized wellness destination, grounded in 5,000 years of traditional healing systems such as Ayurveda, Yoga, Unani, Siddha, and Naturopathy. Supported by rich cultural heritage, diverse landscapes, and a reputation for spiritual authenticity, India continues to attract international wellness travellers seeking holistic, transformative experiences. This article examines the opportunities that strengthen India’s competitive position—such as government-backed initiatives (including the AYUSH Visa), expansion of high-end wellness resorts, and rising global interest in sustainability and authentic cultural immersion—as well as the challenges that threaten its long-term leadership in the global wellness economy.
Drawing on generational analysis, the …
Formulating A Strategy To Drive Indian Medical Tourism In 2026 And Beyond, Naresh Trehan
Formulating A Strategy To Drive Indian Medical Tourism In 2026 And Beyond, Naresh Trehan
Visions in Leisure and Business
Global demand for cross-border health, wellness, and medical services has accelerated in the postpandemic era, driven by rising healthcare costs, long waiting times, and greater patient willingness to seek treatment abroad. India—already home to internationally accredited hospitals, highly trained clinicians, competitive pricing, and strong aviation connectivity—holds a distinctive competitive advantage. This article analyzes India’s current medical tourism strengths and presents a strategic roadmap for expanding the sector in 2026 and beyond through coordinated collaboration between the Government of India (GOI) and the private medical sector.
Drawing on market projections that position global medical tourism to exceed USD 250 billion by …
Standardizing Assessment Of Clinical Performance In Physical Therapy: From Good Intentions To Shared Standards, Arvie Vitente, Carmina Rafael, Rolando Lazaro
Standardizing Assessment Of Clinical Performance In Physical Therapy: From Good Intentions To Shared Standards, Arvie Vitente, Carmina Rafael, Rolando Lazaro
Philippine Journal of Physical Therapy
Clinical education is the crucible in which physical therapy students integrate knowledge, skills, and professional judgment into safe, ethical, and person-centered practice. Yet globally, the assessment of clinical performance remains highly variable, shaped by disparate tools, rubrics, and levels of assessor preparation. While several countries have adopted nationally standardized approaches to clinical assessment, many contexts—including the Philippines—continue to rely on locally developed or institution-specific systems, resulting in inconsistent expectations, inequitable student experiences, and limited capacity for benchmarking, research, and quality improvement. This editorial argues that good intentions alone are insufficient and that the profession must move toward shared, trustworthy standards …
Precision Education In Health Sciences Education: A Call-To-Action For Developing An Interprofessional Strategy, Arvie Vitente, Jennifer Bosworth, Robert Sweet, Rebecca Cozzi, Christopher Galloway, Piotr Szczurek, Melanie Obispo-Young, Eron Bozec, Erica Brkovic, Tina Bobo, Jennifer Lubinski
Precision Education In Health Sciences Education: A Call-To-Action For Developing An Interprofessional Strategy, Arvie Vitente, Jennifer Bosworth, Robert Sweet, Rebecca Cozzi, Christopher Galloway, Piotr Szczurek, Melanie Obispo-Young, Eron Bozec, Erica Brkovic, Tina Bobo, Jennifer Lubinski
Philippine Journal of Physical Therapy
Introduction. Growing learner diversity, expanding biomedical knowledge, and rapid clinical digitization have exposed the limits of on-size-fits-all health sciences training. Competency-Based Education (CBE) has sharpened the focus on outcomes, yet many programs still move learners through fixed sequences, infrequent assessments, and retrospective remediation. Precision Education (PE) offers a complementary, data-enabled approach that uses learning analytics, artificial intelligence (AI), and continuous feedback loops. Embedded within CBE, PE converts competencies from static milestones into dynamic trajectories that can be measured, visualized, and adjusted in real time across the curriculum. This abstract highlights the need for an interprofessional strategy to design, fund, and …
Factors Influencing The Success Of Student Veterans In Higher Education
Factors Influencing The Success Of Student Veterans In Higher Education
Faculty Publications and Presentations
A case study was conducted at a private institution of higher education to gain a deeper understanding of the factors that support student veterans, a nontraditional student demographic in a private institution of higher education. The article explains the interplay and relationship between what nontraditional students bring to the academic experience, the role of educators, and factors contributing to or detracting from their success in higher education. Analysis of key issues related to combat student veterans in higher education revealed common themes and contextual information from which the lessons learned were developed. The results of the study indicate that the …
Community And Academic Synergy For Cancer Survivorship Care Delivery Enhancement (Project Cascade): A Study Protocol For A Pragmatic, Stepped-Wedge, Cluster-Randomized Trial In Texas Primary Care Community Health Centers, Mary-Louise E Millett, Lauren Q Malthaner, Katharine Mccallister, Derek W Craig, Rebecca Eary, Melissa A Valerio-Shewmaker, L Aubree Shay, Suja S Rajan, Hilary Y Ma, Samiran Ghosh, Benjamin F Crabtree, Simon J Craddock Lee, Bijal A Balasubramanian
Community And Academic Synergy For Cancer Survivorship Care Delivery Enhancement (Project Cascade): A Study Protocol For A Pragmatic, Stepped-Wedge, Cluster-Randomized Trial In Texas Primary Care Community Health Centers, Mary-Louise E Millett, Lauren Q Malthaner, Katharine Mccallister, Derek W Craig, Rebecca Eary, Melissa A Valerio-Shewmaker, L Aubree Shay, Suja S Rajan, Hilary Y Ma, Samiran Ghosh, Benjamin F Crabtree, Simon J Craddock Lee, Bijal A Balasubramanian
Faculty, Staff and Student Publications
Background: In the United States, over 18 million individuals are living with cancer. The majority of these cancer survivors also manage other chronic conditions and receive care from multiple specialists, including oncology, cardiology, and primary care clinicians. However, it remains unclear who holds primarily responsibility for coordinating their care across specialties. Because of its generalist nature, primary care is uniquely suited to deliver whole-person and coordinated care for all conditions for cancer survivors. However, primary care teams experience many challenges delivering high-quality survivorship care. While integrating care for all conditions including cancer is a core principle of high-quality primary care, …
Investigation Of Regulated Cell Death (Rcd) Modalities Induced By Copper(Ii), Manganese(Ii) And Silver(I) Complexes Containing Bridging Dicarboxylate And 1,10-Phenanthroline Ligands, Ella O'Sullivan
Doctoral
With the increasing global cancer burden in recent years, there is an urgency to develop novel chemotherapeutic agents. Transition metal complexes represent an attractive class of candidates, owing to their unique electronic and stereochemical properties, as well as their capacity for ligand exchange, redox activity, and catalytic reactivity. These characteristics enable cellular signalling mechanisms that lead to tumour cell cytotoxicity via regulated cell death (RCD) mechanisms. The conventional RCD mechanisms of apoptosis and autophagy are attractive targets for the development of novel complexes because tumour cells evade apoptosis but use autophagy as a survival mechanism when under stress. Therefore, novel …
Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu
Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu
Faculty, Staff and Student Publications
Current discussion surrounding the clinical capabilities of generative language models(GLMs) predominantly centers around multiple-choice question-answer(MCQA) benchmarks derived from clinical licensing examinations. While accepted for human examinees, characteristics unique to GLMs bring into question the validity of such benchmarks. Here, we validate five benchmarks using eight GLMs, ablating for parameter size and reasoning capabilities, validating via prompt permutation three key assumptions that underpin the generalizability of MCQA-based assessments: that knowledge is applied, not memorized, that semantic consistency will lead to consistent answers, and that situations with no answers can be recognized. While large models are more resilient to our perturbations compared …
Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu
Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu
Faculty, Staff and Student Publications
Current discussion surrounding the clinical capabilities of generative language models(GLMs) predominantly centers around multiple-choice question-answer(MCQA) benchmarks derived from clinical licensing examinations. While accepted for human examinees, characteristics unique to GLMs bring into question the validity of such benchmarks. Here, we validate five benchmarks using eight GLMs, ablating for parameter size and reasoning capabilities, validating via prompt permutation three key assumptions that underpin the generalizability of MCQA-based assessments: that knowledge is applied, not memorized, that semantic consistency will lead to consistent answers, and that situations with no answers can be recognized. While large models are more resilient to our perturbations compared …
Comparing The Effectiveness Of Eggshell Spectra From Laser-Induced Break-Down Spectroscopy And Near-Infrared Spectroscopy Using Principal Compo-Nent Analysis To Determine The Authenticity Of Organic Eggs, Ahmad Qusthalani, Rara Mitaphonna, Muliadi Ramli, Rajibussalim Rajibussalim, Kurnia Lahna, Nasrullah Zaini, Nasrullah Idris
Comparing The Effectiveness Of Eggshell Spectra From Laser-Induced Break-Down Spectroscopy And Near-Infrared Spectroscopy Using Principal Compo-Nent Analysis To Determine The Authenticity Of Organic Eggs, Ahmad Qusthalani, Rara Mitaphonna, Muliadi Ramli, Rajibussalim Rajibussalim, Kurnia Lahna, Nasrullah Zaini, Nasrullah Idris
Makara Journal of Science
This study aimed to explore the potential of modern spectroscopy in the authentication of organic and non-organic chicken eggs using near-infrared spectroscopy (NIRS) and laser-induced breakdown spectroscopy (LIBS) spectra. A total of 175 eggs were analyzed, which were grouped into seven categories based on the source of feed given: 100% organic, 100% non-organic, 75% organic, 75% non-organic, 50% organic, free-range chickens, and eggs obtained from the local traditional market. Each group consisted of 25 eggs. NIRS spectra were recorded in the wavelength range of 350–2500 nm, whereas LIBS spectra were recorded in the range of 200–900 nm. A total of …
Information System To Elucidate Dna Sequencing Based On Machine And Deep Learning Techniques, Suhiar Mohammed Zeki Abd Alsammed
Information System To Elucidate Dna Sequencing Based On Machine And Deep Learning Techniques, Suhiar Mohammed Zeki Abd Alsammed
Baghdad Science Journal
The elucidation of DNA sequencing provides great importance in increasing the comprehension of organisms' genomic functions. However, the investigation of concealed structural information preserved within Deoxyribonucleic Acid (DNA) sequencing represents an outstanding challenge. Recently, machine and deep learning have become the techniques of preference for various tasks of genomics modeling, involving the prediction of genetic variation influence on the mechanisms of gene regulation like DNA receptivity and splicing. Therefore, this paper presented an information system for elucidating DNA sequencing data using diverse machine and deep learning techniques. In this system, two encoding methods are utilized for modifying the DNA sequencing …
Collagen Type Ii-Targeting Lentiviral Gene Therapy For Mucopolysaccharidosis Iva, Betul Celik, Sampurna Saikia, Shaukat Khan, Krishna Sai Musini, Shunji Tomatsu
Collagen Type Ii-Targeting Lentiviral Gene Therapy For Mucopolysaccharidosis Iva, Betul Celik, Sampurna Saikia, Shaukat Khan, Krishna Sai Musini, Shunji Tomatsu
Department of Pediatrics Faculty Papers
Mucopolysaccharidosis (MPS IVA) is caused by pathogenic variations in the GALNS gene, leading to the accumulation of glycosaminoglycans in tissues and causing progressive skeletal lesions. While conventional lentiviral vectors (LVs) provide long-term stable expression, they do not deliver therapeutic levels to bone and cartilage. We hypothesized that engineering the LV envelope with a collagen type II-targeting peptide (WYRGRL) increases the binding affinity of the LVs for bone and cartilage. These modified vectors carrying the CBh and COL2A1 promoters delivered the GALNS gene to MPS IVA newborn mice via intravenous (IV) or intraarticular (IA) administration. The peptide-modified LVs exhibited markedly increased …
Loss Of The Maternal Effect Gene Nlrp2 Impairs Embryonic And Extra-Embryonic Development, Revealing A Novel Genetic Cause Of Congenital Anomalies†, Momal Sharif, Zahra Anvar, Imen Chakchouk, Sara H El-Dessouky, Roni Zemet, Eric C Kao, Wessam E Sharaf-Eldin, Ying-Wooi Wan, Zhandong Liu, Pengfei Liu, Michael Jochum, Ignatia B Van Den Veyver
Loss Of The Maternal Effect Gene Nlrp2 Impairs Embryonic And Extra-Embryonic Development, Revealing A Novel Genetic Cause Of Congenital Anomalies†, Momal Sharif, Zahra Anvar, Imen Chakchouk, Sara H El-Dessouky, Roni Zemet, Eric C Kao, Wessam E Sharaf-Eldin, Ying-Wooi Wan, Zhandong Liu, Pengfei Liu, Michael Jochum, Ignatia B Van Den Veyver
Duncan NRI Faculty and Staff Publications
Maternal-effect genes (MEGs) play a crucial role in early mammalian development, and their dysfunction can lead to severe embryonic and extra-embryonic abnormalities. NLRP2, a MEG that encodes a subcortical maternal complex (SCMC) protein, has been implicated in preimplantation development, but its role after implantation remains underexplored. In this study, we investigated the developmental consequences of maternal Nlrp2 loss-of-function in a maternal knockout (KO) mouse model at embryonic day 11.5. Embryos derived from Nlrp2-KO females have abnormal yolk sac vasculature, increased embryonic resorption, craniofacial abnormalities, neural tube defects, and congenital heart defects. Placental architecture is disrupted with an altered junctional zone …
A Spatiotemporal Model Of Cxcl10 As A Master Regulator Of Immune Evasion And Metastasis In Osteosarcoma, Benjamin B Gyau, Tsz-Kwong Man
A Spatiotemporal Model Of Cxcl10 As A Master Regulator Of Immune Evasion And Metastasis In Osteosarcoma, Benjamin B Gyau, Tsz-Kwong Man
Faculty, Staff and Students Publications
The C-X-C motif chemokine ligand 10 (CXCL10) is implicated in the progression of osteosarcoma (OS), the most aggressive pediatric bone malignancy. However, its role often presents a profound clinical paradox: although high circulating levels are strongly linked to poor prognosis, its canonical function is to recruit anti-tumor immune cells. This review unravels these contrasting roles by proposing a novel spatiotemporal model. We argue that in the early stages, immune-evading OS cells initiate the formation of a pre-metastatic niche (PMN) in the lungs, creating a localized inflammatory environment that becomes the primary source of elevated circulating CXCL10. As the disease progresses, …
Amino Acid Signaling In Skeletal Muscle Is Blunted By Prematurity In A Piglet Model, Antonio C Ramos Dos Santos, Agus Suryawan, Ki Beom Jang, Rosemarie D Parada, Mahmoud A Mohammad, Marta L Fiorotto, Teresa A Davis
Amino Acid Signaling In Skeletal Muscle Is Blunted By Prematurity In A Piglet Model, Antonio C Ramos Dos Santos, Agus Suryawan, Ki Beom Jang, Rosemarie D Parada, Mahmoud A Mohammad, Marta L Fiorotto, Teresa A Davis
Faculty, Staff and Students Publications
Background: Preterm (PT) infants are at increased risk for reduced postnatal lean mass accretion. We established that the feeding-induced stimulation of protein synthesis in skeletal muscle is blunted in piglets born PT compared with those born at term.
Objectives: We evaluated the extent to which key components of the amino acid-sensing pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation contribute to anabolic resistance in skeletal muscle of piglets born PT compared with those born term.
Methods: Piglets delivered by cesarean section 10 d PT (n = 23) or at term (n = 22) were administered total parenteral …
Spinal Cord Injury In The Context Of Major Motor Vehicle Collision Trauma: A Retrospective Ecological Analysis Of Global Estimates Across Income Groups, Tim Nutbeam, Jessica Caterson, Colleen J. Saunders, Hendry R. Sawe, Sabariah Faizah Jamaluddin, Ian Roberts, Jason E. Smith, Paulus Ambunda, Willem Stassen
Spinal Cord Injury In The Context Of Major Motor Vehicle Collision Trauma: A Retrospective Ecological Analysis Of Global Estimates Across Income Groups, Tim Nutbeam, Jessica Caterson, Colleen J. Saunders, Hendry R. Sawe, Sabariah Faizah Jamaluddin, Ian Roberts, Jason E. Smith, Paulus Ambunda, Willem Stassen
Peninsula Medical School
Introduction: Road traffic injuries (RTIs) are a leading cause of death globally, especially in low- (LICs) and middle-income countries (LMICs). Despite this burden, post-crash care remains underdeveloped. Many clinical principles of post-crash care focus on spinal cord injury (SCI), yet its incidence is poorly understood. The aim of this study was to describe the incidence of death and non-fatal RTI with a specific focus on SCIs using Global Burden of Disease (GBD) 2019 data. Methods: A retrospective ecological analysis was conducted using GBD 2019 data for 204 countries and territories (2012–2019). We examined the MVC-related mortality, SCIs, and major non-fatal …
Supply Chain Network Based On Blockchain And Intelligent Agent, Hiba Hamdi Hassan, Rana Fareed Ghani
Supply Chain Network Based On Blockchain And Intelligent Agent, Hiba Hamdi Hassan, Rana Fareed Ghani
Journal of Soft Computing and Computer Applications
In agricultural supply chains, the complexity and indeterminacy pose serious challenges to traceability, reliability and confidence today. This challenge is especially acute in the olive oil industry where adulteration, wrong labeling, and uneven chemical quality threaten the actual well-being of producers and consumers. The project aims to design a blockchain-based hybrid architecture with intelligent agents (FNNs) to enhance transparency, reliability and responsiveness in the olive oil supply chain. The Blockchain component enables a completely open, tamper-proof ledger to be built in a very decentralized way and preserved as an archive of every account of its transactions. The intelligent agents contribute …
Tax Trends, E. S. Linett
Tax Clinic, Peter Elder
Estate Planning: Significant Recent Developments Concerning Estate Planning (Part I), Byrle M. Abbin, Robert H. Daskal, David K. Carlson
Estate Planning: Significant Recent Developments Concerning Estate Planning (Part I), Byrle M. Abbin, Robert H. Daskal, David K. Carlson
Tax Adviser
No abstract provided.
Tax Trends, E. S. Linett
The Tax Adviser, Volume 5, Number 11, November 1974, American Institute Of Certified Public Accountants
The Tax Adviser, Volume 5, Number 11, November 1974, American Institute Of Certified Public Accountants
Tax Adviser
No abstract provided.
Tinig-Karakter Sa Mga Pader: Graffiti, Bandalismo, At Mga Banyulatin Sa Piling Panitikang Filipino (Character-Voices On Walls: Graffiti, Vandalism, And Latrinalia In Select Philippine Literature), Harvey James G. Castillo
Tinig-Karakter Sa Mga Pader: Graffiti, Bandalismo, At Mga Banyulatin Sa Piling Panitikang Filipino (Character-Voices On Walls: Graffiti, Vandalism, And Latrinalia In Select Philippine Literature), Harvey James G. Castillo
Filipino Faculty Publications
Makailang beses lilitaw sa tradisyonal na midya at social media sa nagdaang kalahating dekada ang ilang pagtutol, pagbabawal, at pandidiri sa mga graffiti at nagsusulat ng mga graffiti mula sa parehong mamamayan at maykapangyarihan. Bunsod ng paggamit ng mga militanteng grupo sa graffiti bilang anyong pamprotesta sa Kalakhang Maynila, tatagurian ng nakararami ang gayong mga sulatin bilang bandalismo o paninira lamang sa pampubliko o pribadong pagmamay-ari. Taliwas ito sa balintunang paggamit din ng estado at merkado sa graffiti, o estetika ng graffiti, sa pamamahala ng espasyo o pagbebenta ng produkto. Sa ganang ito, bumabaling ang pag-aaral sa panitikan bilang lunan …
Robinson Jeffers' Roan Stallion, Tamar And Other Poems: Centennial Reflections, Rja
Robinson Jeffers' Roan Stallion, Tamar And Other Poems: Centennial Reflections, Rja
Jeffers Studies
No abstract provided.
Comparative Transcriptomics Reveals Novel And Differential Long-Noncoding Rna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang
Comparative Transcriptomics Reveals Novel And Differential Long-Noncoding Rna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang
Food and Animal Sciences Faculty Research
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to the global swine industry. Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of antiviral immunity, but their roles in porcine alveolar macrophages (PAMs)—the primary target of PRRSV—remain poorly characterized. This study presents a genome-wide analysis of lncRNA expression in PAMs stimulated with a PRRS modified live virus (MLV) vaccine and two type I interferons, IFN-α1 and IFN-ω5. Whole-transcriptome sequencing identified over 2000 differentially expressed lncRNAs, with IFN-ω5 inducing the most extensive transcriptional reprogramming. Weighted gene co-expression network analysis (WGCNA) revealed interferon-specific lncRNA-mRNA modules, and functional enrichment showed …
State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education
State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education
California
No abstract provided.