Digital Commons Network^™

Lp-118 Is A Novel B-Cell Lymphoma 2 / Extra-Large Inhibitor That Demonstrates Efficacy In Models Of Venetoclaxresistant Chronic Lymphocytic Leukemia, Janani Ravikrishnan, Daisy Y Diaz-Rohena, Elizabeth Muhowski, Xiaokui Mo, Tzung-Huei Lai, Shrilekha Misra, Charmelle D Williams, John Sanchez, Andrew Mitchell, Suresh Satpati, Elizabeth Perry, Tierney Kaufman, Chaomei Liu, Arletta Lozanski, Gerard Lozanski, Kerrya Rogers, Adam S Kittai, Seema A Bhat, Mary C Collins, Matthew S Davids, Nitin Jain, William G Wierda, Rosa Lapalombella, John C Byrd, Fenlai Tan, Yi Chen, Yu Chen, Yue Shen, Stephen P Anthony, Jennifer A Woyach, Deepa Sampath

Faculty, Staff and Student Publications

Patients with chronic lymphocytic leukemia (CLL) respond well to initial treatment with the B-cell lymphoma 2 (BCL2) inhibitor venetoclax. Upon relapse, they often retain sensitivity to BCL2 targeting, but durability of response remains a concern. We hypothesize that targeting both BCL2 and B-cell lymphoma-extra large (BCLXL) will be a successful strategy to treat CLL, including for patients who relapse on venetoclax. To test this hypothesis, we conducted a pre-clinical investigation of LP-118, a highly potent inhibitor of BCL2 with moderate BCLXL inhibition to minimize platelet toxicity. This study demonstrated that LP-118 induces efficient BAK activation, cytochrome C release, and apoptosis …

Optimal Timing Of Organs-At-Risk-Sparing Adaptive Radiation Therapy For Head-And-Neck Cancer Under Re-Planning Resource Constraints, Fatemeh Nosrat, Cem Dede, Lucas B Mccullum, Raul Garcia, Abdallah S R Mohamed, Jacob G Scott, James E Bates, Brigid A Mcdonald, Kareem A Wahid, Mohamed A Naser, Renjie He, Aysenur Karagoz, Amy C Moreno, Lisanne V Van Dijk, Kristy K Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J Schaefer, Clifton D Fuller

Faculty, Staff and Student Publications

Background and purpose: Prior work on adaptive organ-at-risk (OAR)-sparing radiation therapy has typically reported outcomes based on fixed-number or fixed-interval re-planning, which represent one-size-fits-all approaches and do not account for the variable progression of individual patients' toxicities. The purpose of this study was to determine the personalized optimal timing of re-planning in adaptive OAR-sparing radiation therapy, considering limited re-planning resources, for patients with head and neck cancer (HNC).

Materials and methods: A novel Markov decision process (MDP) model was developed to determine optimal timing of re-planning based on the patient's expected toxicity, characterized by normal tissue complication probability (NTCP), for …

Strawberry Season Settles, The Crimson Nestles, Tra Huong Vo

Student Scholarship

No abstract provided.

The Lived Experiences Of Millennial Black Women Employed By Predominantly White Organizations: An Interpretative Phenomenological Exploration Of Identity Shifting, Natasha Ross

Human Resource Development Theses and Dissertations

Identity shifting is “the intentional process of altering one’s behavior and language based on feelings of exclusion, expectations, and perceptions from others” (Dickens et al., 2018, p. 5). Previous identity shifting research shows that many have used it as a coping mechanism to escape racial and/or gender discrimination or a tool for success. However, there are negative consequences, such as poor mental health, that questions the necessity of using this. Millennial Black women were used as participants because they would offer unique experiences since they experience being at the intersection of being Black, female, and being born within the same …

Nutrition Curriculum Module 10 Banana Food Detectives, Unm Prevention Research Center

Module 10 Nutrition Curriculum

No abstract provided.

Nutrition Curriculum Module 10 Banana Let's Get Cooking, Unm Prevention Research Center

Module 10 Nutrition Curriculum

No abstract provided.

Nutrition Curriculum Module 12 Cabbage Let's Get Cooking, Unm Prevention Research Center

Module 12 Nutrition Curriculum

No abstract provided.

Retirement Grief: Insights For Counseling Praxis, Colette T. Dollarhide

Adultspan Journal

From a personal perspective, this article documents one counselor educator’s experience that might inform the work of counselors who are providing counseling services for those experiencing challenges during retirement.

The Role Of Tgf-Beta Superfamily Members In Immune Homeostasis And Disease, Natalie Eva Nieuwenhuizen, Ioannis Eleftherianos, Piotr Jan Kraj, Maria Semitekolou

Biological Sciences Faculty Publications

[Introduction] The Transforming Growth Factor beta (TGF-beta) superfamily, encompassing molecules such as TGFs, activins, Bone Morphogenetic Proteins (BMPs), Growth/Differentiation Factor (GDFs) and Nodals, represents the largest family of growth and differentiation factors, playing crucial roles in developmental and physiological processes across animal species (1). These molecules are integral to tissue homeostasis and cell fate determination. Among them, TGF-beta is particularly noted for its regulatory influence on immune responses and tissue fibrosis (2, 3). Recent research has expanded our understanding of the immune functions of other superfamily members, including activin A and BMPs (4). These molecules signal through receptor complexes composed …

Genome-Wide Snp Analyses Reveal High Gene Flow Of Endemic Smallscale Croaker (Boesemania Microlepsis) In The Lower Mekong Basin, Quyen Dang Ha Vu, Christopher E. Bird, Oanh Thi Truong, Sang Quang Tran, Ellen E. Biesack, Amanda S. Ackiss, Kent E. Carpenter, Binh Truy Dang

Biological Sciences Faculty Publications

The Smallscale Croaker, Boesemania microlepis, is a valuable fishery resource in the Mekong River basin that lacks clear biological data to understand its basic ecology and conservation management priorities. This species is common in the southernmost floodplain of the Mekong which extends from Tonlé Sap in Cambodia to the Mekong Delta in Vietnam. This floodplain is of particular biodiversity conservation concern because of the many upstream dams that restrict water flow in an ecology that relies heavily on a flood-pulse cycle. The literature regarding the biology B. microlepis in this region contains conflicting ideas that populations are both highly …

Policy Paper On Incorporating Migrant Children In A Strengthened Public Education System, Amira Abdelaziz, Dina Ibrahim, Dunia Zaatar

Papers, Posters, and Presentations

A transit, destination, and sending country, Egypt generously hosts more than one million refugees and asylum seekers (UNHCR, 2025), in addition to several migrants estimated at nine million in 2022 (IOM, 2022). Against this backdrop, the country is currently facing growing challenges in ensuring access to quality, inclusive, and equitable primary education for migrant and refugee children, particularly following the arrival of Sudanese nationals since April 2023, when the conflict in Sudan erupted. Egypt’s new Asylum Law No. 164 of 2024 grants de jure access to basic education for all refugee children until the age of 14, yet the law …

Differential Associations Among Psychological Flexibility Components, Depressive Symptoms And Sense Of Belonging In First Semester College Students., Ti Hsu, Cristina Nardini, Gabriel M. Velez, Elizabeth Raposa

College of Education Faculty Research and Publications

Objective. The transition to college is associated with rising rates of depressive symptoms and decreased well-being. It is critical to identify protective psychological factors for this period. One possible protective factor is psychological flexibility, or the ability to pursue self-identified values despite distressing thoughts and emotions. This study examined associations among psychological flexibility components and well-being outcomes in first semester college students. Participants: The sample consisted of 238 diverse first-semester college students recruited from five universities. Method: Using structural equation modeling, we examined associations among three components of psychological flexibility and two dimensions of well-being (i.e., depressive symptoms and sense …

Switching To Tumescent Dissection In Mastectomy, Emna Bakillah, Ari Brooks, Seye Adekeye

Department of Surgery Faculty Papers

Introduction: Tumescent dissection (TUM) combines the use of crystalloid, local anesthetic, and epinephrine to create a bloodless plane to raise skin flaps. We aim to compare outcomes of TUM versus standard electrocautery dissection in mastectomies with and without reconstruction. Methods: We conducted a retrospective cohort study of patients who underwent mastectomy by a single surgeon between January 2016 and October 2020 utilizing the electronic medical record. The primary outcome was complication rate, and the secondary outcome was operative time. Chi-squared analysis and two-sample t-tests were used to examine outcomes. Results: Among 242 patients, 141 patients underwent TUM and 101 …

Endocrine Responses To Two Distinct Foraging Contexts In The Bonobo (Pan Paniscus), Lauren Mitchell

Master's Theses

In gregarious animals, a social structure characterized by female dominance is relatively rare. However, bonobos (Pan paniscus), one of the two species most closely related to humans, are characterized by partial female dominance, with females forming close social bonds. In contrast, chimpanzees (Pan troglodytes), a close relative of the bonobo, are characterized by strong male-male bonding and social dominance with female chimpanzees lacking close social bonds. There is a lack of consensus concerning the reasons for these behavioral differences in Pan, specifically, the physiological processes responsible for female dominance in bonobos. The role of hormones …

2025 Merc Annual Report, David B. Naff, Jesse Senechal, Paula L. Ogston-Nobile

MERC Publications

This is the annual report of the Metropolitan Educational Research Consortium (MERC) at Virginia Commonwealth University for the 2024-2025 academic year. It includes vignettes depicting MERC activities in the past year that align with each of its five principles: research, relevance, rigor, multiple perspectives, and impact. It concludes with a discussion of MERC's commitment moving forward.

Supporting Students In Transition To And From High School, David Naff, Jamelle Simmons, Meleah Ellison, Shelby Garofalo, Laura Thoene, Kim Dupre, Sooyeon Moon, Karli Johanson, Paul Harris, Martin Darby, William L. Parker, Tracy Booker, Janel Miley, Mysia Perry, Xun Liu, Maggie Szydlowski, Ahmed Abbas

MERC Publications

This report is part of a two-part series focused on supporting students in transition across PK-12 education. Specifically, it explores transitions into and out of high school school. The report includes a synthesis of recent peer-reviewed literature, analysis of publicly available data (with a specific focus on Virginia and the metropolitan Richmond region), and summary of relevant federal, state, and school division-level policies. It answers the following questions:

1. What are key considerations for supporting students in transition to and from high school in the MERC region?

2. How do federal, state, and division policies guide support for student transitions …

“With Love, From Me To You:” Replacing The Unconstitutional All-Comer Provision With Favorable Conflict Of Laws Principles To Still Confer The Postmortem Right Of Publicity, Jackson Polish

Case Western Reserve Law Review

No abstract provided.

A Relational Approach To Public Private Contracting For Innovation: The Example Of Arpa-H, Liza Vertinsky

Case Western Reserve Law Review

No abstract provided.

Strengthening Critical Infrastructure For Equity And Resilience: Findings From The Environmental Justice Data Project, Nakeina E. Douglas-Glenn Phd, Luisa Nazareno Phd, Emily Schreer, Amidu Kalokoh, Curtis Brown Mpa, Melvin Brown, Yali Pang Phd, Morgan Woodle Phd, Research Institute For Social Equity Rise

Research Institute for Social Equity

In 2023, the Research Institute for Social Equity, an institute of the Virginia Commonwealth University’s L. Douglas Wilder School of Government and Public Affairs, partnered with Resilient Virginia to explore the impact of climate change and degradation due to disasters and environmental hazards on the critical infrastructure in and around historically marginalized and underserved communities in the Richmond and Southside Virginia areas. During the study period, 2023-2025, the research team conducted both primary and secondary research in three Virginia localities: Charles City County, the City of Emporia, and a portion of the City of Richmond. Secondary research included a thorough …

Scalable Mental Health Analysis Using Big Data: A Demographic And Geographic Study Of Depressive Symptoms, Saikrishna Katamneni, Anitha Bommana, Naman Pandya, Gokul Kareti, Sangwhan Cha

Harrisburg University Other Works

This project explores the application of Big Data technologies for large-scale mental health analysis, focusing on the prevalence of depressive disorder symptoms across diverse demographic and geographic subgroups. Utilizing Apache Spark on Google Cloud Dataproc, the system efficiently processed millions of survey records stored in Hadoop Distributed File System (HDFS). Through comprehensive data preprocessing, aggregation, and visualization, the analysis revealed critical trends and disparities in mental health outcomes related to age, race, education level, gender, and state. Seasonal variations and subgroup-specific confidence intervals were also examined to identify high-risk populations and areas of measurement uncertainty. The results offer actionable insights …

Readmission Prediction For Diabetic Patients: A Scalable Big Data Approach For Resource-Constrained Hospitals, Rhema Ike, Minjae Kim, Bhushan Chindarkar, Sangwhan Cha

Harrisburg University Other Works

Hospital readmissions, particularly among diabetic patients, place a significant burden on healthcare systems by increasing operational costs and straining limited resources. This project presents a scalable, cloud-based solution that leverages machine learning and big data analytics to predict 30-day hospital readmissions. Utilizing a ten-year dataset of over 100,000 patient records, we implemented a Random Forest classifier trained on clinical, demographic, and hospitalization data. The system architecture integrates Google Cloud Platform services—including BigQuery, Vertex AI, and Looker Studio—with a custom Python/Flask web application for real-time data input and inference. Data preprocessing and feature engineering were conducted in Vertex AI Workbench, enabling …

Computational Bridges: Enhancing Natural Language Processing Of Swahili., Joyce Murungi

Harrisburg University Other Works

Swahili remains significantly underrepresented in natural language processing (NLP) despite being one of the most widely spoken languages in Africa. Computational Bridges: Enhancing Natural Language Processing of Swahili addresses this gap through computational linguistics, corpus creation, and large-scale analysis of Swahili syntax and lexical structure. Central to this study is GUMZO, a novel corpus developed from spontaneous conversational data collected from YouTube videos, television panel discussions, political speeches, religious discourse, and unscripted broadcasts. Unlike many existing datasets that rely on formal or translated text, GUMZO captures authentic language use and provides a stronger foundation for NLP research involving low-resource languages. …

Rrh Library Newsletter, Winter 2025, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: New Database: Embase; St. Lawrence Health New Database Access; EBSCOhost New Database User Interface; Discovery Tool Update

Preserving The Future: Recognizing Intergenerational Equity In United States Constitutional Jurisprudence In Light Of Evolving Climate Rights Litigation, Molly Morgan

Cardozo Journal of Equal Rights & Social Justice

Climate rights litigation is an essential part of holding states accountable for their climate change obligations. This type of litigation has increased across the globe, and domestic and international courts have issued landmark rulings that serve as precedent for reinforcing state obligations and protecting constitutional and human rights in the process. One focus of these cases is intergenerational equity, which implicates the theory that inadequate state action on climate change violates the rights of future generations. This Article explores the evolution of this theory in domestic and international law, illustrating its increasing importance in climate rights litigation and the necessity …

Equitable Incorporation: How History And Tradition Can Progressively Redefine The Fourteenth Amendment, Robert D'Alessandro

Cardozo Journal of Equal Rights & Social Justice

The Fourteenth Amendment, designed to ensure equality before the law, has been misinterpreted by the Supreme Court through its incorporation doctrine, leading to rulings that harm marginalized communities. The article advocates for "Equitable Incorporation," a doctrine requiring courts to consider the impact of their decisions on historically discriminated groups, ensuring the Amendment's purpose of equity and justice is upheld. This approach would necessitate the incorporation of unincorporated rights and reinterpret existing ones to reflect the Amendment's equitable intent.

Annotated Legal Bibliography

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

Shining Light On Policy: The Case For Solar Panel Mandates On New Construction Projects, Emily Glazier

Cardozo Journal of Equal Rights & Social Justice

The note argues that solar panel mandates on new construction projects are a necessary and sensible approach to reducing greenhouse gas emissions and achieving climate goals, but their implementation must include provisions to protect vulnerable communities and address environmental justice concerns. While such mandates face legal and political challenges, the benefits of decreased emissions and energy independence outweigh the costs, particularly when paired with measures like community solar systems, incentives, and exemptions.

Tap, Swipe, And Connect: Exploring Perceptions Of Inclusivity Through Smartphone Design And Accessibility, Carmen Van Ommen

Doctoral Dissertations and Master's Theses

There has been an increasing importance placed on customization of products and desire for the product to allow the consumer to express themselves or fit into desired social groups with their product choices. Designing products to be inclusive can encompass these desires, as well as ensure that a wide range of user groups can use the products well. In general, there is little research in the field of perceptions of inclusivity with consumer technology products. Previous research has validated a scale to measure Perceptions of Technology Product Inclusivity (PTPI) with different user groups and technology product groups, however no research …

Mini-Maps, Crucial Or Controversial: Assessing The Influence Of Perceived Spatial Orientation And Cognitive Mapping Performance On Video Game User Experience, Angela Le

Doctoral Dissertations and Master's Theses

Decades of game studies, also known as video games research, have revealed frequent video gameplay is positively correlated with enhanced cognition. An area of study that is limited, however, is the relationship between spatial cognition, specifically the domains of spatial orientation and cognitive mapping and their effects on video game user experience for games employing visual navigational aids. Video game user experience is influenced by many factors such as graphics and audio, gameplay mechanics, user interface design, etc. The present study aims to explore whether spatial abilities influence and are significantly correlated with user experience for games using heads-up displays …

The Effect Of Need For Cognition & Need For Affect On Human Reliance And Artificial Intelligence Interactions, Aliyah Mcgowan

Doctoral Dissertations and Master's Theses

Abstract

With the increased use of Artificial Intelligence (AI) automations in fields like medical diagnoses and mental health queries, there are concerns regarding an individual’s trust and reliance on the technology. Reliance on AI output may lead an individual to accept inaccurate or incorrect information without further analysis. Trust may influence reliance and trust formation may be a product of affective processing. This study investigated the relationship between Need for Affect (NFA), Need for Cognition (NFC), and trust and reliance on AI interactions. Participants were assessed on the NFA scale for willingness to approach or avoid emotional stimuli, the NFC …