Digital Commons Network^™

Cath-Ddg: Towards Robust Mutation Effect Prediction On Protein-Protein Interactions Out Of Cath Homologous Superfamily, Guanglei Yu, Xuehua Bi, Teng Ma, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

Motivation: Protein-protein interactions (PPIs) are fundamental aspects in understanding biological processes. Accurately predicting the effects of mutations on PPIs remains a critical requirement for drug design and disease mechanistic studies. Recently, deep learning models using protein 3D structures have become predominant for predicting mutation effects. However, significant challenges remain in practical applications, in part due to the considerable disparity in generalization capabilities between easy and hard mutations. Specifically, a hard mutation is defined as one with its maximum TM-score < 0.6 when compared to the training set. Additionally, compared to physics-based approaches, deep learning models may overestimate performance due to potential data leakage.

Results: We propose new training/test splits that mitigate data leakage according to the CATH homologous superfamily. Under the constraints of physical …

Optiselect And Enshap: Integrating Machine Learning And Game Theory For Ischemic Stroke Prediction, Pritam Chakraborty, Anjan Bandyopadhyay, Sricheta Parul, Sujata Swain, Partha Sarathy Banerjee, Tapas Si, Hong Qin, Saurav Mallik

Computer Science Faculty Publications

Stroke analysis using game theory and machine learning techniques. The study investigates the use of the Shapley value in predictive ischemic brain stroke analysis. Initially, preference algorithms identify the most important features in various machine learning models, including logistic regression, K-nearest neighbor, decision tree, support vector machine (linear kernel), support vector machine ( RBF kernel), neural networks, etc. For each sample, the top 3, 4, and 5 features are evaluated and selected to evaluate their performance. The Shapley value method was used to rank the models using their best four features based on their predictive capabilities. As a result, better-performing …

From Philosophy To Nlu: Evolving Definitions With Research Hypotheses, Jian Wu, Sarah Rajtmajer

Computer Science Faculty Publications

Over the past decades, alongside advancements in natural language processing, significant attention has been paid to training models to automatically extract, understand, test, and generate hypotheses in open and scientific domains. However, interpretations of the term hypothesis for various natural language understanding (NLU) tasks have migrated from traditional definitions in the natural, social, and formal sciences. Even within NLU, we observe differences defining hypotheses across literature. In this paper, we overview and delineate various definitions of hypothesis. Especially, we discern the nuances of definitions across recently published NLU tasks. We highlight the importance of well-structured and well-defined hypotheses, particularly as …

Effective Pii Extraction From Llms Through Augmented Few-Shot Learning, Shuai Cheng, Shu Meng, Haitao Xu, Haoran Zhang, Shuai Hao, Chuan Yue, Wenrui Ma, Meng Han, Fang Zhang, Zhao Li

Computer Science Faculty Publications

Large Language Models (LLMs) exhibit strong natural language processing capabilities but also pose significant privacy risks, particularly regarding the leakage of Personally Identifiable Information (PII) embedded in their training data. Existing PII extraction methods suffer from the limitations of low success rates or impracticality for large-scale PII extraction. In this study, we propose a novel PII extraction approach based on enhanced few-shot learning techniques, which achieves efficient and cost-effective PII retrieval without relying on fine-tuning or jailbreaking. We evaluated our approach on both open-source and closed-source LLMs. The experimental results demonstrate that, for non-targeted PII extraction, the attack success rate …

Exploring The Educational Gap Of Virginia English Language Learners: Challenges And Opportunities For Academic Success, Amanda Purcell, Sochitl Rodriguez Kauffman

UROP Posters

English Language Learners (ELLs) in the state of Virginia have significantly lower scores in the Standards of Learning (SOL) assessment exam than those of their English-speaking peers. The SOL measures students’ mastery of knowledge and skills taught in the classroom, and over the last decade, passing rates of the assessment’s core subjects amongst ELLs have continued to decrease and remain relatively low. In the 2023-2024 academic year, the average passing rate for ELLs who took the Writing SOL was only 26%, with Science being not much higher at 29%, and Reading at 33%. For the non-ELL student body, average rates …

Ocean Acidification Mitigation: Potential Expansion Of Sav Restoration Strategy In The Chesapeake Bay, Cree N. Taylor

UROP Posters

Zostera marina is a species of marine macrophyte that has been largely prioritized in past submerged aquatic vegetation (SAV) restoration initiatives within the Chesapeake Bay because of its 1) previous abundance, 2) demonstrated carbon burial abilities, and 3) observed ability for meadows of Z. marina to ameliorate low pH conditions. Due to the temperature variability and poor water quality associated with anthropogenic disturbances in the Chesapeake Bay, Z. Marina beds have experienced several die-off events with limited capacity for regrowth. This systematic review explored the possible benefits of focusing future SAV recovery initiatives on ensuring a diverse variety of SAV …

Analysis Of Differential Gene Expression In Androgen-Independent Clones Derived From The Mycap Pca Cell Line, Jessie L. Tignor, Melanie Sinanian, Richard Inho Joh, David Gewirtz, Jason Reed

UROP Posters

Androgen deprivation therapy (ADT) is a primary treatment strategy for prostate cancer (PCa), yet many tumors eventually develop androgen independence, leading to treatment resistance. To investigate the molecular changes underlying this transition, we analyzed differential gene expression in four androgen-independent (AI) clones derived from the Myc-CaP prostate cancer cell line using RNA sequencing. Gene expression profiles were compared to the parental Myc-CaP line, and differentially expressed genes (DEGs) were identified using DESeq2 and edgeR. The AI clones exhibited significant downregulation of senescence-associated genes, including Ezh2 and lamin B1, suggesting a loss of senescence-related chromatin repression. Additionally, upregulation of Wnt pathway …

The Built Environment And The Systemic Agenda, Heciel J. Nieves Bonilla

UROP Posters

The built environment in the United States, characterized in large part by suburban sprawl and car-dependent infrastructure, has significant negative impacts on public health, economic mobility, and environmental sustainability. This paper examines the consequences of car-centric development, highlighting its role in exacerbating social and economic inequalities, increasing traffic-related fatalities, and contributing to climate change through excessive carbon emissions. The analysis reveals that a majority of Americans feel forced into car ownership due to inadequate alternative transportation options, leading to financial strain and adverse health outcomes, including obesity and air pollution-related diseases. The historical roots of these development patterns are traced …

Examining Sociodemographic And Clinical Factors Associated With Smoking Behaviors Among Black Breast And Gynecological Cancer Survivors, Ida M. Adeso, Jian He, Ashley Turner, Arnethea L. Sutton

UROP Posters

Black breast and gynecological cancer survivors experience poorer outcomes than their non-Black counterparts. Although multifactorial, one contributor may be cigarette smoking behaviors. The purpose of this study was to identify demographic, clinical, and social drivers of health (SDoH) factors associated with smoking behaviors in Black breast and gynecological cancer survivors.

We conducted a secondary analysis of survey data collected from an ongoing cross-sectional study. Summary statistics (e.g., means, frequencies) were computed for all factors of interest. Chi square test of independence, t test, and logistic regression assessed the associations between demographic, clinical, and SDoH factors (e.g., social support) and the …

Still Faces, Different Places: An Assessment Of The Literature On The Face-To-Face Still Face Procedure For Cultural Congruence, Merilyn Arikkat, Leslie B. Lantz, Patricia Kinser

UROP Posters

Cultural understanding is a factor that impacts reliability of research results for observational studies. It is important to include participants of minority groups in research, as many people of color face disproportionate challenges in terms of healthcare access and resources. Within the context of mother-infant attachment, a technique known as the Face-to-Face Still Face procedure can be utilized to observe attachment styles and the bond between a parent and their infant. In order to combat subjectivity within the coding process for this Face-to-Face Still Face procedure, cultural congruence between the participants being observed in the study and the coding researchers …

Doping Hybrid Photopolymerisable Glass With Bodipy Photosensitiser: An Efficient Approach To Improve Uv-Resistance, Luca Sorridente, Tatsiana Mikulchyk, Metodej Dvoracek, Mikhail A. Filatov, Izabela Naydenova, Kevin P. Murphy

Conference Papers

The development of photosensitive materials with improved performance and extended functionality is crucial for advancing holographic technologies. This study presents the modification and characterization of a recently reported photopolymerisable glass composition, focusing on achieving an optimal balance between maximizing photosensitivity of the material during recording and minimizing the impact of UV light on the performance of the recorded holographic structure. Building on these findings, the ultimate goal is to develop UV-resistant holographic optical elements for wavefront sensing in space applications. The research approach is based on introducing a photosensitiser with weaker UV absorption than the typically used in this material …

A New G Family: Properties, Characterizations, Different Estimation Methods And Port-Var Analysis For U.K. Insurance Claims And U.S. House Prices Data Sets, Ahmad M. Aboalkhair, Gholamhossein Hamedani, Nazar Ali Ahmed, Mohamed Ibrahim, Mohammad A. Zayed, Haitham M. Yousof

Mathematical and Statistical Science Faculty Research and Publications

This paper introduces a new class of probability distributions, termed the generated log exponentiated polynomial (GLEP) family, designed to enhance flexibility in modeling complex real financial data. The proposed family is constructed through a novel cumulative distribution function that combines logarithmic and exponentiated polynomial structures, allowing for rich distributional shapes and tail behaviors. We present comprehensive mathematical properties, including useful series expansions for the density, cumulative, and quantile functions, which facilitate the derivation of moments, generating functions, and order statistics. Characterization results based on the reverse hazard function and conditional expectations are established. The model parameters are estimated using various …

Accuracy And Repeatability Of Autorefraction In Young Adults: A Comparison Of Cycloplegic And Non-Cycloplegic Methods, Megan Doyle, Veronica O'Dwyer O'Dwyer, Michael Moore, Síofra Harrington

Articles

Clinical Relevance: Cycloplegic refraction remains crucial in young adults, where accommodative activity can obscure accurate refractive status. Autorefractor repeatabil­ity is essential for precise optical correction and refractive error categorisation in clinical and research settings.

Background: Cycloplegic autorefraction is recommended for individuals up to 20 years to prevent hyperopia underestimation and myopia overestimation. This study evaluated differences between non-cycloplegic and cycloplegic spherical equivalent refraction following cyclopentolate hydrochloride (cycloplegic agent) administration in young adults. This study also explored whether this difference varied by refractive status (hyperopia (≥1.00D), emmetropia ( >−0.50, < 1.00D), myopia (≤-0.50D)) or pre- instillation of proxymetacaine hydrochloride and whether cycloplegia improved autorefractor repeatability.

Methods: Participants were 182 young adults (17–30 years) (mean (standard deviation): 21.66 …

Therapy In The Age Of Ai: How Young Adults Seek Help, Support, And Solutions, Faith Maeba, Isabella Quilon, Abigail Adade

UROP Posters

Therapy has long been a foundational approach for addressing mental health, but advances in digital technology have led many young adults, especially Generation Z, to increasingly turn to AI tools for support. Rising costs, limited access to providers, and long wait times have further boosted the appeal of AI-based mental-health solutions. Despite this growing interest, the use of AI for emotional and psychological support raises important questions about trust, empathy, safety, and the ethical responsibilities of mental-health providers and developers. We conducted a brief scoping review of research on AI-based mental-health tools and student help-seeking behaviors. Searches were performed on …

Work In Progress: Using Internships As Means For Indirect Assessment Of Abet Criteria 3 “1-7” Student Outcomes, Robert Bass

Electrical and Computer Engineering Faculty Publications and Presentations

The Electrical & Computer Engineering (ECE) Department at Portland State University (PSU) has developed a Power Engineering Internship (PEI) program that provides engineering career development pathways within the electric utility industry. The PEI is supported by several U.S. Department of Energy grants that aim to develop quality career opportunities and develop a future electric utility workforce that represents the nation’s diverse populations. The PSU ECE Department intends to use surveys of internship participants as assessment tools for its ABET accreditation process, in particular, the ABET Criteria 3 Student Outcomes (SOs). SOs relate to the knowledge, skills, and behaviors that students …

Spanking And Children's Approaches To Learning: Estimates From A Longitudinal Matched-Sample Design, Jeehye Kang, Christina M. Rodriguez

Sociology & Criminal Justice Faculty Publications

One form of corporal punishment commonly used in the United States is spanking. Spanking is a well-known risk factor for adverse child development, although its influence on children's approaches to learning (ATL) has been largely overlooked. Existing research is particularly limited in inadequately considering multiple confounds and selection biases in children's exposure to spanking. This study examined the links between spanking and children's ATL, using a matched-group design to strengthen causal estimates among children aged 5 to 7.5 (N = similar to 12,800) from the Early Childhood Longitudinal Study, Kindergarten Class of 2010-2011. Entropy-balanced matching mitigated selection and confounding biases, …

U.S. Residents' Current Attitudes Towards Immigrants And Immigration: A Study From The Life In Hampton Roads Survey, Daniel K. Pryce

Sociology & Criminal Justice Faculty Publications

Immigration is a fiery topic in U.S. society, as it generally brings to a boil native-born citizens’ disparate attitudes toward immigrants and immigration. While immigration has its fierce supporters and opponents alike, the topic provides fodder for politicians who use it to stoke the fear of an impending “immigrant invasion” among citizens. This is why scholars must regularly undertake empirical studies to assess community members’ views about immigrants and immigration in U.S. society. To add to the contemporary immigration debate, I analyze data from a random sample of 610 respondents who reside in the seven cities that make up the …

An Empirical Assessment Of New Jersey's Mistaken Imprisonment Act, Jeffrey Gutman

GW Law Faculty Publications & Other Works

In their article “Compensation for the Convicted Innocent in New Jersey: Problems and Recommended Solutions,” Professors D. Michael Risinger and Lesley Risinger masterfully recount the history and flaws of New Jersey’s Mistaken Imprisonment Act.1 The professors recommend concrete and common-sense amendments to the Act that, if enacted, would resolve statutory ambiguities, remedy bad public policy, and make more generous an Act intended to benefit the wrongfully convicted, but which often falls short of that goal.

This article will provide empirical and comparative context for the Risingers’ proposals. By examining why the claims of exonerees had been denied or never made, …

Agency Delay And The Courts, Aram A. Gavoor, Steven A. Platt

GW Law Faculty Publications & Other Works

Administrative delay plagues the modern regulatory state, yet scholars and courts lack a coherent framework for analyzing when delay becomes unlawful and how to remedy it. This Article provides the first comprehensive examination of judicial oversight of agency delay, tracing the evolution from common law mandamus through the delay provisions of the Administrative Procedure Act. It reveals critical distinctions between these mechanisms that courts have increasingly elided, leading to doctrinal confusion and ineffective remedies. On account of the second Trump administration’s Department of Government Efficiency initiatives, this topic takes on unprecedented urgency because administration policies to reduce workforce and restructure …

Justice Delayed By Design: The Harms Of Our Protracted Divorce System, Laurie S. Kohn

GW Law Faculty Publications & Other Works

Divorce is the termination of a legal relationship. It is necessary for the enforceable division of property and debts between spouses as well as for remarriage. However, it’s not simply a lawsuit. Instead, it most often involves a seismic shift in the very foundations of life and, as such, frequently provokes, exacerbates, and exposes insecurities, instabilities, and vulnerabilities. This legal process also involves a unique relationship between litigants who are former intimate partners—often co-parents—and who are largely unrepresented and therefore engaged in a new form of relationship as opposing parties to a lawsuit. Given these complex dynamics, one might hope …

Standing, Randall S. Abate

GW Law Faculty Publications & Other Works

Chapter 4 explores the intricacies of the legal principle of standing, its role in climate litigation, and how it impacts the ability of parties to bring climate change-related lawsuits to trial. The author discusses interpretations of standing across different jurisdictions, such as the United States, New Zealand, and countries in Europe, and explains how these interpretations can either impede or facilitate climate litigation. He distils emerging best practice from this analysis, providing an insightful guide for future climate lawsuits. The author then identifies emerging best practice in interpreting standing rules in a flexible manner, thus allowing a broader range of …

The Looming Threat Of Uninsured Nonbank Stablecoins, Arthur E. Wilmarth Jr.

GW Law Faculty Publications & Other Works

On May 21, 2025, the U.S. Senate voted to begin final consideration of the “GENIUS Act.” Despite its lofty title, the bill would create grave threats to our financial system and economy by allowing nonbanks to issue stablecoins without the protections provided by federal deposit insurance and other regulatory safeguards governing FDIC-insured banks. The GENIUS Act would set the stage for future runs on stablecoins triggering systemic financial crises and requiring government bailouts.

The great majority of global stablecoins promise to maintain parity with the U.S. dollar and are functionally equivalent to bank deposits. Stablecoins are mainly used as payment …

Feature Comment: Institutional Amnesia And The Neglect Of The Federal Acquisition Workforce, Jessica Tillipman, Steven L. Schooner

GW Law Faculty Publications & Other Works

Public procurement regimes may be constrained by rules, but people - procurement professionals - animate the process. Despite spending over $750 billion last year on federal contracts, the U.S. Government continues to deprioritize the professional capacity of its acquisition workforce. This article bemoans and critiques the persistent failure to recruit, develop, and retain procurement personnel, a failure exacerbated by politically driven downsizing, inadequate investments in workforce development, and misplaced reliance on procedural reform—most recently evidenced by the so-called “Revolutionary FAR Overhaul.” Drawing on historical data, case studies, and recent Government Accountability Office reports, the authors document how decades of underinvestment …

The Future Of The Duty To Engage In Reasoned Decision Making: The Choice Between A Textual Approach And A Pragmatic Approach, Richard J. Pierce Jr

GW Law Faculty Publications & Other Works

In this contribution to a symposium on the future of the duty to engage in reasoned decision making, Professor Pierce argues that the Supreme Court faces a decision whether to retain the present robust version of the duty to engage in reasoned decision making and to extend it to actions taken by the president or to abandon or greatly weaken it. He urges the Court to retain and expand the scope of the duty to include actions taken by the president. He expresses concern, however, that the Court may instead abandon or significantly weaken the duty.

Ai And Doctrinal Collapse, Alicia Solow-Niederman

GW Law Faculty Publications & Other Works

Artificial intelligence runs on data. But the two legal regimes that govern data—information privacy law and copyright law—are under pressure. Formally, each regime demands different things. Functionally, the boundaries between them are blurring, and their distinct rules and logics are becoming illegible.

This Article identifies this phenomenon, which I call “inter-regime doctrinal collapse,” and exposes the individual and institutional consequences. Left unchecked, the data acquisition status quo favors established corporate players and impedes law’s ability to constrain the arbitrary exercise of private power. Through analysis of pending litigation, discovery disputes, and licensing agreements, this Article exposes two dominant exploitation tactics …

The Supply Chain Is A Circle: Ai, Privacy, And People, Alicia Solow-Niederman

GW Law Faculty Publications & Other Works

Artificial Intelligence (AI) governance underscores the AI “supply chain” and the “many hands” involved in the creation of AI systems. Although invaluable, this production-centered approach risks overlooking what happens when people use AI tools. That’s a mistake, because user interactions determine the real-world impact of AI.

This Essay contends that regulating AI and holding the appropriate actors responsible requires far more attention to what happens after deployment of an AI system. The supply chain is an invaluable start, but it’s not a linear chain. Rather, it is a circle that must incorporate users’ engagement with AI tools as part of …

Policy Brief: The Federal Banking Agencies Should Withdraw Their Deeply Misguided Proposal To Weaken Leverage Capital Requirements For The Largest U.S. Banks, Arthur E. Wilmarth Jr.

GW Law Faculty Publications & Other Works

On July 10, 2025, federal banking agencies issued a proposed regulation that would dangerously weaken capital requirements for the largest U.S. banking organizations. The proposed rule would significantly reduce the enhanced supplementary leverage ratio (eSLR) requirements for U.S. global systemically important banking organizations (G-SIBs). If adopted, the proposed rule would allow U.S. G-SIBs to become woefully undercapitalized, as their predecessors were at the outbreak of the global financial crisis of 2007-09. The proposed rule would make U.S. G-SIBs highly likely to fail during future systemic financial crises, with catastrophic consequences for our financial system, economy, and society.

As explained in …

Mahmoud V. Taylor: Cause Or Effect Of Disruptions In The Public Schools?, Richard Katskee, Ira C. Lupu

GW Law Faculty Publications & Other Works

Mahmoud v. Taylor represents an extraordinary departure from long-standing constitutional norms about the rights of parents of children in public schools. In Mahmoud, the Supreme Court upheld a Free Exercise Clause claim by parents in Montgomery County, Maryland, who sought to have their children (grades K–5) excused from readings that contain LGBTQ characters and themes. The majority opinion by Justice Alito rests on a highly controversial reading of Wisconsin v. Yoder.

Part I of the paper provides the doctrinal and historical backdrop to Mahmoud, which reflects the acute tension between a once-narrow understanding of Yoder and the post-Obergefell backlash against …

The Civil Jury Trial Clause Of The Seventh Amendment, Renée Lettow Lerner

GW Law Faculty Publications & Other Works

This essay discusses the Civil Jury Trial Clause—also known as the Preservation Clause—of the Seventh Amendment to the U.S. Constitution. I provide background on English civil jury practice in common-law courts in the late eighteenth century and distinguish it from equity practice in the Court of Chancery. The essay describes Blackstone’s praise for the civil jury as well as the role the civil jury played in the events leading up to the American Revolution. The question of a federal constitutional right to civil jury trial provoked heated disputes in the Philadelphia Convention and the ratification debates. The ratification debates featured …

When The Math Matters: Finding The “Glue” In Class Action Commonality Determinations, Robin L. Juni

GW Law Faculty Publications & Other Works

This Article is another offering in the “When the Math Matters” series, seeking to help readers understand use of mathematical and scientific concepts in legal contexts and unpack how to do things better. This Article focuses on the seminal case of Wal- Mart Stores, Inc. v. Dukes, 564 U.S. 338 (2011), describing how the analytical approach to identify whether a class could be certified for purposes of that litigation continues to resonate through recent cases in the federal courts. The Article explains the statistical analysis that lawyers must present to unpack a correlative analysis in similar cases, focusing on adverse …