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2025

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Three Wishes Project: Individualizing End Of Life Care, Sarah Seddon Rn Jan 2025

Three Wishes Project: Individualizing End Of Life Care, Sarah Seddon Rn

Nursing Publications, Posters, & Presentations

This poster was presented at the 2025 Nursing Research Symposium. •We used the journal article to create tangible ways to individualize the dying process •A binder ways created with the different “wishes” nurses can provide.


Optimizing Defibrillation Response: A Quality Improvement Initiative In The Cath Lab, Sara Cullis Bsn, Rn Jan 2025

Optimizing Defibrillation Response: A Quality Improvement Initiative In The Cath Lab, Sara Cullis Bsn, Rn

Nursing Publications, Posters, & Presentations

This poster was presented at the 2025 Parkview Nursing Research Symposium.

Patients undergoing diagnostic or emergent procedures in the Cardiac Cath Lab are at risk of developing lethal arrhythmias, which require immediate defibrillation to prevent adverse outcomes. Currently, the use of paddles and the absence of pre-applied defibrillator pads delay response time during critical events, increasing the risk of morbidity and mortality. Additionally, there is a liability when staff assume which patients are “high risk” versus “diagnostic,” as even seemingly low-risk cases can rapidly deteriorate without warning. This quality improvement initiative aims to address this gap by ensuring defibrillator pads …


Best Practice In Geriatric Fracture Care: Impact Of Early Urinary Catheter Removal On Cauti Incidence, Samantha Tiede Bsn, Rn, Onc, Heather Kegerreis Msn, Rn, Cmsrn Jan 2025

Best Practice In Geriatric Fracture Care: Impact Of Early Urinary Catheter Removal On Cauti Incidence, Samantha Tiede Bsn, Rn, Onc, Heather Kegerreis Msn, Rn, Cmsrn

Nursing Publications, Posters, & Presentations

Poster presented at the 2025 Parkview Nursing Research Symposium.

Objective: Evaluate the effectiveness of urinary catheter removal by POD1 on CAUTI incidence in GFPs.


Use Of Machine Learning Models To Predict Microaspiration Measured By Tracheal Pepsin A., Annette Bourgault, Ilana Logvinov, Chang Liu, Rui Xie, Jan Powers Phd, Rn, Ccrn, Mary Lou Sole Jan 2025

Use Of Machine Learning Models To Predict Microaspiration Measured By Tracheal Pepsin A., Annette Bourgault, Ilana Logvinov, Chang Liu, Rui Xie, Jan Powers Phd, Rn, Ccrn, Mary Lou Sole

Nursing Publications, Posters, & Presentations

BACKGROUND: Enteral feeding intolerance, a common type of gastrointestinal dysfunction leading to underfeeding, is associated with increased mortality. Tracheal pepsin A, an indicator of microaspiration, was found in 39% of patients within 24 hours of enteral feeding. Tracheal pepsin A is a potential biomarker of enteral feeding intolerance.

OBJECTIVE: To identify predictors of microaspiration (tracheal or oral pepsin A). It was hypothesized that variables predicting the presence of tracheal pepsin A might be similar to predictors of enteral feeding intolerance.

METHODS: In this secondary analysis, machine learning models were fit for 283 adults receiving mechanical ventilation who had tracheal and …


Cultivating Plain Language Skills For Engineering Students, Catherine Wong, Cynthia Carlson Jan 2025

Cultivating Plain Language Skills For Engineering Students, Catherine Wong, Cynthia Carlson

Faculty Publications

While engineers are learning the vocabulary of the profession, understandably, they want to practice, and perhaps show their professors that they are proficient. This leads to student writing that is overly complicated and full of jargon. This is not the type of document that would be clear to the public, or even to a professional outside of the narrowly focused field of the particular engineer. After graduation, engineers’ writing becomes exponentially more important. Often approval of projects relies on residents’ or clients’ understanding of engineers’ work. For example, an engineering firm completing an investigation of an important health concern such …


Data Literacy Competencies In Context: Employee Perspectives From The Workplace, Patricia Condon, Wendy G. Pothier Jan 2025

Data Literacy Competencies In Context: Employee Perspectives From The Workplace, Patricia Condon, Wendy G. Pothier

Faculty Publications

Data literacy is essential in today’s workplace, and professionals across roles and experience levels recognize its value. This article reports on findings from interviews with 16 supply chain and logistics professionals. The study examines how seven proposed data literacy competencies align with workplace needs, how employees address the data literacy gap, and how librarians can support workforce readiness. Findings highlight opportunities for libraries to bridge the data literacy gap through instruction and resources development that integrate technical and non-technical data skills with information literacy.


Overturning Roe V. Wade And Pre-Medical Students’ Views And Medical School Choices, Emma J. Hastings, M. Courtney Hughes Jan 2025

Overturning Roe V. Wade And Pre-Medical Students’ Views And Medical School Choices, Emma J. Hastings, M. Courtney Hughes

Faculty Articles, Papers, and Other Scholarship

The overturning of Roe v. Wade in Dobbs v. Jackson Women’s Health Organization (2022) has led to varying abortion laws across states in the U.S., potentially influencing medical education choices. While some research has examined abortion policy changes and medical residencies and fellowship decisions, none has investigated abortion policy and medical school decisions. This study aims to determine whether pre-medical students’ personal views on abortion influence their willingness to attend medical schools in states where abortion is illegal at all stages EXCEPT to save the life of the mother. A cross-sectional survey was distributed to pre-medical organizations at the two …


Utilizing 16s Rna Sequencing To Identify Bacterial Species Colonizing Lame Birds With Bacterial Chondronecrosis With Osteomyelitis, Kara Hoover, Andi Asnayanti, Adnan Alrubaye Jan 2025

Utilizing 16s Rna Sequencing To Identify Bacterial Species Colonizing Lame Birds With Bacterial Chondronecrosis With Osteomyelitis, Kara Hoover, Andi Asnayanti, Adnan Alrubaye

2025 Research Poster Competition

Poultry lameness has become prevalent in recent years due to high growth rates in broiler chickens. Bacterial chondronecrosis with osteomyelitis (BCO), the main cause of lameness, is characterized by necrosis of the femur and tibia in afflicted birds. Heavier birds are more susceptible to bacterial stress in these regions due to increased pressure on their growth plates. BCO lameness poses both ethical and financial threats to the poultry industry, as up to 15% of flocks can become affected during outbreaks. The purpose of this experiment was to identify bacterial species present in birds with BCO lameness. 1,800 chicks were randomly …


An Operational Field Study: A Comparison Of Piloting Uncrewed Underwater Vehicles And Uncrewed Aircraft Systems, David Thirtyacre, Joseph Cerreta, Pete Miller, Kimberly Luthi, Jolee Thirtyacre Jan 2025

An Operational Field Study: A Comparison Of Piloting Uncrewed Underwater Vehicles And Uncrewed Aircraft Systems, David Thirtyacre, Joseph Cerreta, Pete Miller, Kimberly Luthi, Jolee Thirtyacre

Publications

and operations, the ability to cross-train personnel in both Uncrewed Underwater Vehicles and Small Uncrewed Aircraft System operations has become a focal point for efficiency and workforce optimization. This study presents a comparative analysis of the operational and human factor considerations involved in piloting mini UUV and sUASs, highlighting the key similarities and differences in control methods, environmental influences, navigation, emergency procedures, and situational awareness. A qualitative experimental field study was conducted between July 2024 and October 2024, involving real-world deployments of both systems in maritime and aerial environments. Findings indicated that while UUV and sUAS operators relied on remote …


Factors Contributing To Fatalities In Helicopter Emergency Medical Service Accidents, Jenna Korentsides, Joseph R. Keebler, Mihhail Berezovski, Alex Chaparro Jan 2025

Factors Contributing To Fatalities In Helicopter Emergency Medical Service Accidents, Jenna Korentsides, Joseph R. Keebler, Mihhail Berezovski, Alex Chaparro

Publications

INTRODUCTION: T his study aimed to update and reinforce previous research on helicopter emergency medical service accidents in the United States. By investigating predictors of fatalities after helicopter emergency medical service crashes through the application of machine learning techniques, we updated existing data sets and sought to uncover patterns that traditional analysis might not reveal.

METHODS: Using the National Transportation Safety Board database, the authors analyzed a dataset of 267 helicopter emergency medical service accidents between 1991–2022. We first calculated fatalities odds ratios for each condition. We then plotted geospatial locations of all reported accidents. Finally, we used XGBoost regression …


Adverse Childhood Experiences, Somatic Symptoms, And Athletic Injury Among Collegiate Student-Athletes, Samuel Aswegan Jan 2025

Adverse Childhood Experiences, Somatic Symptoms, And Athletic Injury Among Collegiate Student-Athletes, Samuel Aswegan

Research Papers

No abstract provided.


Probiotic Supplementation In Ruminants: A Sustainable Alternative For Enhancing Health, Milk Production, And Rumen Function, Jovahna Williams Jan 2025

Probiotic Supplementation In Ruminants: A Sustainable Alternative For Enhancing Health, Milk Production, And Rumen Function, Jovahna Williams

Research Papers

This paper examines the effects of probiotic supplementation on ruminant animals, with emphasis on several key areas including ruminant animal health, milk production, rumen microbial profile, microbial protein synthesis and diversity, and patterns of rumen fermentation. As global interest in economically and biologically sustainable alternatives to antibiotics continues to grow, probiotics have emerged as promising candidates for improving livestock productivity while promoting animal and consumer welfare.

The primary objectives of this paper are to evaluate the specific effects and benefits of different probiotic strains in ruminants, to assess their potential as replacements for traditional growth-promoting substances such as fermentation enhancers …


Comparisons Of Major Healthcare Systems In Europe And The United States Through The 20th And 21st Century, Isaac Shaw Jan 2025

Comparisons Of Major Healthcare Systems In Europe And The United States Through The 20th And 21st Century, Isaac Shaw

Research Papers

This paper examines how healthcare systems have been created in four countries, the USSR (and then Russia post 1991), Poland, Germany and the United States, how they changed throughout the decades, their efficacy, as well as focusing on aspects such as funding, budget allocation, care quality, and the overall structure of the system. These cases were chosen to give a contrast between the development and subsequent abandonment of the Soviet Semashko system which proposed an entirely state ran and centralized program that was imposed on other Soviet Bloc Countries and the United States’ decentralized employer led health insurance system. Germany …


Molecular Interactions Between The Shellfish Pathogen Vibrio Coralliilyticus Re22 And The Probiont Phaeobacter Inhibens S4sm, Jessica Coppersmith Jan 2025

Molecular Interactions Between The Shellfish Pathogen Vibrio Coralliilyticus Re22 And The Probiont Phaeobacter Inhibens S4sm, Jessica Coppersmith

Open Access Dissertations

Oyster larvae aquaculture is an important industry, both economically and environmentally, helping to create sustainable food systems by supplying seed oysters to farms, and also to restoration projects aimed at building coastal resilience and improving water quality by rejuvenating wild populations. However, oyster larvae are highly susceptible to rapid mortality events, crashes, which can seriously impact the industry. One source of these crashes in hatchery systems is vibriosis, caused by pathogenic species of Vibrio bacteria that are ubiquitous in temperate coastal waters, and with rising surface water temperatures their prevalence and virulence are increasing. To prevent these larval crashes from …


Searching Effectively: Basic Principles And Practical Tips For Better Results, Roy E. Brown Jan 2025

Searching Effectively: Basic Principles And Practical Tips For Better Results, Roy E. Brown

VCU Libraries Faculty and Staff Publications

This handout updates Doing a Good Search: Basic Rules and Search Tips, originally published in 2024. It outlines the basic principles of doing a good search, from identifying a topic and formulating a clear question to selecting and searching at least two databases. It also includes information on Boolean operators (AND, OR, NOT), subject headings, and Google Scholar. New to this iteration of the document are best practices for using artificial intelligence in literature and evidence searches.

Remember: Searching is an iterative process, which involves repeated cycles of refinement. Your approach will shift depending on the specific question you're trying …


To Manufacture And Sell: The Erosion Of Gun Manufacturers' Immunity Under Plcaa's Predicate Exception Extending Liability For Cartel Violence, Jessica Spurling Jan 2025

To Manufacture And Sell: The Erosion Of Gun Manufacturers' Immunity Under Plcaa's Predicate Exception Extending Liability For Cartel Violence, Jessica Spurling

Penn State Law Review (2003 - Present)

No abstract provided.


Closing The Gap: Resolving The Circuit Split On Prior Pay In Equal Pay Act Claims, Jessica Shoemaker Jan 2025

Closing The Gap: Resolving The Circuit Split On Prior Pay In Equal Pay Act Claims, Jessica Shoemaker

Penn State Law Review (2003 - Present)

No abstract provided.


Burdened By The Algorithm: Credit Reporting Agencies Should Bear The Burden Of Proving Reasonable Procedures In The Age Of Ai, Alexandra Klemme Jan 2025

Burdened By The Algorithm: Credit Reporting Agencies Should Bear The Burden Of Proving Reasonable Procedures In The Age Of Ai, Alexandra Klemme

Penn State Law Review (2003 - Present)

No abstract provided.


Prevalence Of Insecticide Resistance Gene In Aedes Albopictus Populations Of Central Illinois, Merylann Akinyi Ochieng Jan 2025

Prevalence Of Insecticide Resistance Gene In Aedes Albopictus Populations Of Central Illinois, Merylann Akinyi Ochieng

Masters Theses

The Asian tiger mosquito, Aedes albopictus, is a significant vector for diseases such as Dengue, Chikungunya, and Zika. Its increasing resistance to insecticides poses a critical challenge for vector control efforts. This study investigates knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) genes, specifically V1016G and F1534C, which are associated with pyrethroid resistance. Aedes albopictus populations from Central Illinois were analyzed using allele-specific PCR techniques to address three primary objectives: (1) determining whether V1016G and F1534C mutations are present in these populations, (2) determining which mutation is more widespread, and (3) investigating how resistance gene …


I Can’T, I’M On-Call: The Psychological Effects Of On-Call Duty On Graduate Assistants In Residence Life, Dyjerlynn T. Peter Jan 2025

I Can’T, I’M On-Call: The Psychological Effects Of On-Call Duty On Graduate Assistants In Residence Life, Dyjerlynn T. Peter

Masters Theses

Graduate Assistants (GAs) face various demands such as conducting research, completing coursework, holding assistantships, and other personal responsibilities. GAs working in housing and residence life (HRL) departments face unique challenges, especially those who serve as crisis responders for students who live on-campus. This study examines the mental health challenges faced by graduate assistants in housing and residence life who live on-campus and serve in on-call roles at higher education institutions. It explores the effects of vicarious trauma, compassion fatigue, and burnout, offering key findings, trends, and recommendations while sharing personal stories of GAs balancing on-call duties with graduate studies.


Time To Reassess: Campus Programming In The First Six Weeks And Its Impact On Belonging For First-Time Students, Joe Smith Jan 2025

Time To Reassess: Campus Programming In The First Six Weeks And Its Impact On Belonging For First-Time Students, Joe Smith

Masters Theses

Research has shown that a student’s first six weeks of college have a strong impact on the rest of their college experience. Because of this, institutions concentrate programming efforts in the first six weeks of the academic year to increase the likelihood of positive outcomes for their first-time students. However, little research has been done on this topic in recent years. This quantitative study sought to examine first-time student event attendance in the first six weeks of the academic year and its impact on sense of belonging, which has been shown to be an important factor of the college experience. …


Buscando El Paraíso: Imposter Syndrome Amongst First-Generation Latino/A/X Students At Predominately White Institutions, Luis Fernando Paniagua Jan 2025

Buscando El Paraíso: Imposter Syndrome Amongst First-Generation Latino/A/X Students At Predominately White Institutions, Luis Fernando Paniagua

Masters Theses

As more first-generation Latino/a/x college students enter universities across the United States, it is essential to understand the various challenges this population may face. One major challenge these students may face is the psychological phenomenon known as imposter syndrome. This study was conducted to understand the causes of imposter syndrome in first-generation Latino/a/x college students as they attend a predominantly White institution (PWI). Using a semi-structured phenomenological design, data was collected from six participants at a medium-size PWI in the Midwest. Qualitative analysis revealed that there is a connection between Latino/a/x students and imposter syndrome being developed both prior to …


Investigating The Pathways Between Social Factors, Physical Activity, And Mental Health On Cognitive Efficiency In Young Adults, Emma Hurston-Gates Jan 2025

Investigating The Pathways Between Social Factors, Physical Activity, And Mental Health On Cognitive Efficiency In Young Adults, Emma Hurston-Gates

Masters Theses

Cognitive health is important across the life span and cognitive functions, particularly executive functions, are positively correlated with subjective well-being and success in adulthood (Loprinzi, 2013). The present study aimed to investigate how social factors, mental health, and physical activity impacts cognition in young adults. Young adults aged 18-30 (N = 134) answered questionnaires regarding levels of physical activity, social support, social participation, anxiety, depression, and overall well-being. Participants completed Trail Making Tasks A and B to measure their cognitive efficiency (i.e., combined processing speed, psychological flexibility, visual search, and attention). Across all samples, one of the most consistent …


Assessing Ecological And Food Web Responses To Small-Scale Stream Restorations In Urban And Agricultural Streams, Sydney Mcandrews Jan 2025

Assessing Ecological And Food Web Responses To Small-Scale Stream Restorations In Urban And Agricultural Streams, Sydney Mcandrews

Masters Theses

Urban and agricultural streams across the Midwestern United States are vulnerable to elevated pollution, eutrophication, habitat simplification, and losses of sensitive species. Instream habitat restoration is increasingly used to mitigate the impacts of rapid land-use change. This study synthesizes habitat and biological responses from a 2020 urban stream restoration in the Saline Branch (Urbana, Illinois) and evaluates food web responses from both the Saline Branch and a 2010 restoration in Kickapoo Creek (Charleston, Illinois), an agricultural stream. In the Saline Branch, four years of fish and three years of habitat and macroinvertebrate pre-restoration surveys were compared to three years of …


Prevalence Of Cannabis Use Disorders And Associated Factors Among Privately Insured Adults With Epilepsy, Katarzyna Czerniak, Youngran Kim, Refugio Sepulveda, Sahiti Myneni, Robert Addy, Ross Shegog Jan 2025

Prevalence Of Cannabis Use Disorders And Associated Factors Among Privately Insured Adults With Epilepsy, Katarzyna Czerniak, Youngran Kim, Refugio Sepulveda, Sahiti Myneni, Robert Addy, Ross Shegog

Faculty, Staff and Student Publications

Background: As cannabis is increasingly used as a treatment option for epilepsy, people with epilepsy (PWE) may be at higher risk of developing cannabis use disorder (CUD). This study aimed to estimate the prevalence of CUD among privately insured PWE in the United States using IQVIA's 2022 PharMetrics® Plus for Academics health plan claims database.

Methods: A cross-sectional analysis was conducted using 2022 IQVIA PharMetrics® Plus for Academics health plan claims data containing longitudinal view of inpatient and outpatient services, prescription and office/outpatient administered drugs, costs and detailed enrollment information. Individuals with epilepsy aged 18 years and older were included. …


Sustaining Substance Use Recovery Housing For People Taking Medications For Opioid Use Disorder: Diverse Funding, Strategic Partnerships, And Charging Rent, I Niles Zoschke, Kathryn R Gallardo, Danielle Gillespie, Hannah L N Stewart, Serena A Rodriguez, Sheryl A Mccurdy, J Michael Wilkerson Jan 2025

Sustaining Substance Use Recovery Housing For People Taking Medications For Opioid Use Disorder: Diverse Funding, Strategic Partnerships, And Charging Rent, I Niles Zoschke, Kathryn R Gallardo, Danielle Gillespie, Hannah L N Stewart, Serena A Rodriguez, Sheryl A Mccurdy, J Michael Wilkerson

Faculty, Staff and Student Publications

Introduction: Opioid use disorder is a U.S. epidemic, and recovery housing plays a critical role by providing stable, supportive environments that promote long-term recovery. However, little is known about the sustainability of recovery homes, particularly those serving people taking medications for opioid use disorder.

Methods: We applied thematic analysis to interviews with 29 staff and operators from 10 recovery homes serving people taking medications for opioid use disorder across five Texas cities.

Results: Operators relied on diverse funding sources, leveraged strategic partnerships and professional certifications, and planned to charge rent when public funding ended. Staff and operators balanced financial sustainability …


Dental Care Trajectories Among Formerly Incarcerated Older Adults In The United States, Alexander Testa, Luis Mijares, Mateus Renno Santos, Vahed Maroufy, Dylan B Jackson, Rafael Samper-Ternent, Rahma Mungia, Ana C Neumann Jan 2025

Dental Care Trajectories Among Formerly Incarcerated Older Adults In The United States, Alexander Testa, Luis Mijares, Mateus Renno Santos, Vahed Maroufy, Dylan B Jackson, Rafael Samper-Ternent, Rahma Mungia, Ana C Neumann

Faculty, Staff and Student Publications

A growing body of research has documented an association between prior incarceration and lower dental care use, yet the longitudinal impact of prior incarceration on dental care patterns over time among older adults remains unexplored. This study aims to investigate whether prior incarceration is associated with differing trajectories of dental care use among older adults in the United States. Data were drawn from the 2012-2020 waves of the Health and Retirement Study (HRS), a nationally representative longitudinal survey of older adults in the United States (n =  5,893). Group-based trajectory modeling was used to estimate dental care use patterns over …


Assessing Sun Protection Policies In Texas School Districts Located In Counties With The Lowest And Highest Melanoma Risk: Content Analysis And Cross-Sectional Study, Nabeel Ahmad, Brooke Bartley, Stephanie Zhang, Madison M Taylor, Karl Schrader, Kehe Zhang, Hung Quoc Doan, Cici Bauer, Kelly C Nelson, Jennifer Cofer Jan 2025

Assessing Sun Protection Policies In Texas School Districts Located In Counties With The Lowest And Highest Melanoma Risk: Content Analysis And Cross-Sectional Study, Nabeel Ahmad, Brooke Bartley, Stephanie Zhang, Madison M Taylor, Karl Schrader, Kehe Zhang, Hung Quoc Doan, Cici Bauer, Kelly C Nelson, Jennifer Cofer

Faculty, Staff and Student Publications

Introduction

School policy can encourage sun safe habits, such as wearing hats and applying sunscreen. However, sun safety policies (SSP) have not been formally assessed for Texas independent school districts (ISDs), particularly in counties with the highest melanoma incidence relative risk (RR). This study aims to assess the presence, strength, and intent of SSPs across Texas ISDs located in counties with the highest and lowest melanoma incidence. We also identify factors correlated with stronger SSP.

Methods

Eleven components of SSPs from 102 ISDs were evaluated in this cross-sectional study by examining school district websites, official documents, social media, media appearances, …


Impact Of Pre-Transplant Immune Checkpoint Inhibitor Use On Post-Transplant Outcomes In Hcc: A Systematic Review And Individual Patient Data Meta-Analysis, Mohammad Saeid Rezaee-Zavareh, Yee Hui Yeo, Tielong Wang, Zhiyong Guo, Parissa Tabrizian, Stephen C Ward, Fatma Barakat, Tarek I Hassanein, Shravan Dave, Veeral Ajmera, Sherrie Bhoori, Vincenzo Mazzaferro, David M H Chascsa, Margaret C Liu, Elizabeth S Aby, John R Lake, Miguel Sogbe, Bruno Sangro, Maen Abdelrahim, Abdullah Esmail, Andreas Schmiderer, Yasmina Chouik, Mark Rudolph, Davendra Sohal, Heloise Giudicelli, Manon Allaire, Mehmet Akce, Jessica Guadagno, Clara Y Tow, Hatef Massoumi, Paolo De Simone, Elise Kang, Robyn D Gartrell, Mercedes Martinez, Ricardo Paz-Fumagalli, Beau B Toskich, Nguyen H Tran, Gabriela Azevedo Solino, Dra Mariana Poltronieri Pacheco, Richard S Kalman, Vatche G Agopian, Neil Mehta, Neehar D Parikh, Amit G Singal, Ju Dong Yang Jan 2025

Impact Of Pre-Transplant Immune Checkpoint Inhibitor Use On Post-Transplant Outcomes In Hcc: A Systematic Review And Individual Patient Data Meta-Analysis, Mohammad Saeid Rezaee-Zavareh, Yee Hui Yeo, Tielong Wang, Zhiyong Guo, Parissa Tabrizian, Stephen C Ward, Fatma Barakat, Tarek I Hassanein, Shravan Dave, Veeral Ajmera, Sherrie Bhoori, Vincenzo Mazzaferro, David M H Chascsa, Margaret C Liu, Elizabeth S Aby, John R Lake, Miguel Sogbe, Bruno Sangro, Maen Abdelrahim, Abdullah Esmail, Andreas Schmiderer, Yasmina Chouik, Mark Rudolph, Davendra Sohal, Heloise Giudicelli, Manon Allaire, Mehmet Akce, Jessica Guadagno, Clara Y Tow, Hatef Massoumi, Paolo De Simone, Elise Kang, Robyn D Gartrell, Mercedes Martinez, Ricardo Paz-Fumagalli, Beau B Toskich, Nguyen H Tran, Gabriela Azevedo Solino, Dra Mariana Poltronieri Pacheco, Richard S Kalman, Vatche G Agopian, Neil Mehta, Neehar D Parikh, Amit G Singal, Ju Dong Yang

Faculty, Staff and Student Publications

Background & aims: Treatment with immune checkpoint inhibitors (ICIs) for hepatocellular carcinoma (HCC) prior to liver transplantation (LT) has been reported; however, ICIs may elevate the risk of allograft rejection and impact other clinical outcomes. This study aims to summarize the impact of ICI use on post-LT outcomes.

Methods: In this individual patient data meta-analysis, we searched databases to identify HCC cases treated with ICIs before LT, detailing allograft rejection, HCC recurrence, and overall survival. We performed Cox regression analysis to identify risk factors for allograft rejection.

Results: Among 91 eligible patients, with a median (IQR) follow-up of 690.0 (654.5) …


Risk Of Post-Acute Symptoms Among Adults: A Comparison Study Of Severe Covid-19, Pneumonia, And Influenza, Caroline M Schaefer, Trudy Millard Krause, George L Delclos, Raymond S Greenberg Jan 2025

Risk Of Post-Acute Symptoms Among Adults: A Comparison Study Of Severe Covid-19, Pneumonia, And Influenza, Caroline M Schaefer, Trudy Millard Krause, George L Delclos, Raymond S Greenberg

Faculty, Staff and Student Publications

Background: A retrospective cohort study was undertaken to assess the relationship between initial disease severity of COVID-19 and the risk of post-acute symptoms. The COVID-19 cohort was compared against influenza and pneumonia cohorts to assess whether risk of post-acute symptoms differed.

Methods: Administrative health claims data were obtained for commercially insured and Medicare Advantage covered adults (≥ 18 years) with symptomatic laboratory-confirmed COVID-19 diagnosed in 2020 (n=121,205), and similar cohorts of influenza (n=20,844) and pneumonia (n=29,052) patients diagnosed prior to the pandemic. Post-acute symptoms were assessed at four weeks, three and six months following initial diagnosis.

Results: Among the patients …