Digital Commons Network^™

Glucose Limitation And The Second Glycolysis Peak In Stimulated Macrophages, Melih Karabacak

2025 Research Poster Competition

Previous studies have shown that individuals exposed to fever temperatures are much more likely to combat infections compared to those who are at normal body temperatures. However, in recent years, achieving fever responses has gotten much more difficult. Fortunately, in Dr. Durdik’s lab, it has been seen that effective fever temperatures can be generated artificially. The primary focus of the Durdik lab is an understudied field: the relationship between macrophage activity and fever temperatures. One key piece of information discovered from this research is the pattern of macrophages to go through different levels of glycolysis and mitochondrial respiration, with the …

Unbridled Healing: Identifying The Barriers Of Equine-Assisted Therapy, Sally A. Hamm, Amanda Terrell

2025 Research Poster Competition

Despite the documented benefits of equine-assisted therapy (EAT) for mental health conditions, this complementary approach remains underutilized. This qualitative study investigated barriers preventing wider EAT implementation by examining challenges faced by clients, facilities, and volunteers. Data collected through open-ended surveys from 33 participants and the researcher's autoethnographic observations revealed eight common barriers: Accessibility (48 mentions), Money (43), Time (30), Awareness (23), Physical Factors (13), Relationships (13), Risk (13), and Weather (7). Clients identified financial constraints as their primary barrier, particularly insurance limitations. Facilitators struggled most with accessibility challenges, including lack of resources, trained staff, suitable horses, and appropriate facilities. Volunteers …

Implications And Pathophysiology Of Neuroinflammation In Pediatric Patients With Traumatic Brain Injury: An Updated Review, Shalin S Shah, Arya J Shetty, David T Johnston, Caroline L Hanan, Brendan T O'Reilly, Max A Skibber, Ahmed T Massoud, Banghe Zhu, Eva M Sevick-Muraca, Jenifer Juranek, Charles S Cox, Manish N Shah

Faculty, Staff and Student Publications

Traumatic Brain Injury (TBI) in children is a profound public health issue with the potential to disrupt cognitive, behavioral, and psychosocial development significantly. This review provides an updated examination of the role of neuroinflammation in pediatric TBI, emphasizing its dual impact on injury progression and recovery. Highlighted is the complex interplay of primary and secondary injury mechanisms, including the critical contributions of neuroinflammatory responses mediated by central and peripheral immune cells. Advances in biomarker identification and imaging techniques are discussed, showcasing how tools like diffusion tensor imaging (DTI) and positron emission tomography (PET) enhance our understanding of neuroinflammatory processes. The …

The Scoop, Vol. 11 Issue 10, January 2025, Health Sciences Library

Volume 11

Latest news and updates from the Health Sciences Library in our monthly newsletter for January 2025. Please see page 2 for a text-only version of this issue!

The Fearless Decision And The Future Of Race-Conscious Charities, Chenglin Liu

Faculty Articles

Historically, courts tended to differentiate between invidious discrimination against racial minorities and benign discrimination against whites in the context of affirmative action movements. With the social movements galvanized by the conservatives and the change of composition of the Supreme Courts and lower courts, the feasibility of race-conscious measures aimed at helping minorities is substantially reduced. The conservatives' win in Fearless, coupled with the Trump Administration's attacks on DEI, have produced a self-censoring effect on charitable organizations. Because of these threats, race-conscious charities will have to modify their practices to become more "inclusive" or face legal challenges from conservatives.

The Research Examining Factors Associated With The Opioid Crisis Among Urban Adults (Refocus), Mona K.M. Goggins, Paige Orphé, Jovonna Atkinson, Brittany Miller-Roenigk, Kaylee A. Palomino, Danelle Stevens-Watkins

Educational, School, and Counseling Psychology Faculty Publications

Introduction: Deaths due to opioid-related overdoses have increased across the United States. Specifically in the state of Kentucky, African Americans are the only population that continues to experience an increase in opioid-related deaths. Previous literature highlights African Americans having unique drug use patterns due to systematic barriers and how these barriers limit access to protective factors and substance use treatment. The current study aims to specify patterns of African American non-medical prescription opioid use (NMPOU) and how these patterns may differ based on biological sex and generational cohort. Also, this study plans on using this data on patterns to inform …

Navigating Access To Pre-Exposure Prophylaxis (Prep), Carlos C. Mahaffey, Rohan D. Jeremiah, Andrew M. O’Neil, Déjà N. Clement, Isabel Cava, Fracisco R. Ruiz, Randolph D. Hubach, Danelle Stevens-Watkins

Educational, School, and Counseling Psychology Faculty Publications

Pre-exposure prophylaxis (PrEP) has contributed significantly to stabilizing HIV incidence rates across most populations. However, significant disparities in HIV incidence and PrEP uptake persist among Black men who have sex with men (BMSM). This study delved into the individual, sociocultural, and structural factors associated with PrEP access and uptake among 28 BMSM residing in designated HIV hotspots. Participants were recruited from communities identified as “high priority” by the US Department of Health and Human Services’ Ending the HIV Epidemic in the US initiative. Participants completed semi-structured interviews focusing on PrEP awareness, access, and barriers to uptake. Guided by the Socioecological …

Mental Health And Treatment Use In Undergraduate Engineering Students, Matthew D. Whitwer, Sarah A. Wilson, Joseph H. Hammer, Brenna Gomer

Educational, School, and Counseling Psychology Faculty Publications

Background: Engineering students experience high levels of distress and low rates of mental health treatment seeking, yet there is a gap in knowledge around how this compares with that of students in other fields of study. Given the influence of social identity (e.g., gender identity, race/ethnicity) on mental health and treatment seeking, it is important to account for sociodemographic variation across fields when performing such comparisons. Purpose: This study used Andersen's Behavioral Model to compare mental health distress and treatment use between students in engineering and other fields while controlling for sociodemographic factors. Methods: Survey data came from the 2021–2022 …

Financial Health Literacy Of Community-Dwelling Older Adults: A Qualitative Research Study, Kimberly Davis

Theses and Dissertations

Background: Financial health literacy (FHL) is an emerging concept with unique application to older adults. Multiple complexities converge in older age that create increased financial vulnerability (e.g., retirement, chronic disease). However, low financial and health literacy are common in older adults, impacting their ability to self-manage. The AWV’s focus on prevention offers an opportunity to incorporate a proactive approach to financial-related assessment. This study will explore the perceived value of assessing FHL in primary care settings and the financial-related barriers and facilitators to implementing the personalized prevention plan.

Methods: The conceptual framework was guided by the Individual and Family Self-Management …

Commencement Program, 2025, Cuny John Jay College Of Criminal Justice

Reports and Publications from John Jay College

Commencement Programs are handed out at each graduation. They include information on honorary degrees, awards and prizes and candidates for degree. However, they cannot be considered an official record of conferring of degrees.

Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher

Master of Science in Forensic Science Directed Research Projects

Xylazine is a nonopioid veterinary sedative and an α2 adrenergic receptor agonist. It emerged in the opioid epidemic as an adulterant of illicit fentanyl. As xylazine becomes more involved in fatal overdoses, it is relevant to elucidate its biodistribution post-exposure due to its exacerbation of adverse events, namely respiratory depression, as xylazine’s contributions to existing adverse effects of synthetic opioids is understudied. A bioanalytical method to quantify xylazine and select metabolites in tissue using LC-QToF was validated and applied to a preclinical mouse model in order to characterize xylazine’s biodistribution in whole blood and six tissues at a dose known …

Impact Of Substrates And Deposition Time On Bacteria Associated With Saliva Samples And Its Implication On A Bacterial Signature-Based Body Fluid Identification Method, Olisdey Galano Cruz

Master of Science in Forensic Science Directed Research Projects

Traditional serological methods for body fluid detection are limited by poor specificity and sensitivity, lacking confirmatory capability and thereby increasing the risk of false positives that may compromise the integrity of forensic investigations. While molecular methods such as mRNA, miRNA, and DNA methylation offer improved specificity, they are often hindered by marker instability and operational complexity in routine forensic workflows. Bacterial signature profiling has emerged as a promising alternative, offering enhanced stability, abundance, and compatibility with existing DNA workflows. However, its forensic implementation requires further validation. This study evaluated the effects of substrate type and storage time on the salivary …

Novel Time-Since-Deposition Signatures For Canine Blood; Implications For Animal Cruelty Investigations, Alysia M. Townsley

Master of Science in Forensic Science Directed Research Projects

Dogfighting is a felony in all 50 states and is often tied to other organized crime activities including gambling, narcotics, and weapons trafficking. Because of the clandestine nature of dogfighting crimes, it may be necessary to determine the age of blood samples from suspected events, not just the source. In this study, flow cytometry was used to identify cellular autofluorescence signatures for estimating TSD (time-since-deposition) in canine blood deposits up to 6 months old. To accomplish this, blood was taken from canines of various chronological ages and breeds, then deposited to create TSD samples ranging between 1 day and 180 …

Transforming Numbers And Narratives Into Impact At The Richmond Ed Fund, Jasmine C. Brown, Rochelle Clarke, Truc-Mai Nguyen

Doctor of Education Capstones

The Richmond Ed Fund (REF) has been a nonprofit partner to Richmond Public Schools (RPS) for over two decades. During this time, they provided valuable support through enrichment programs, scholarships, and teacher development to the RPS community. In 2019, the organization shifted its focus from direct program operation to major gifts fundraising to align with the RPS strategic plan’s five priorities. To better reflect its renewed mission and enhance its visibility within the community, in 2024 REF underwent a major rebranding focused on expanding impact, increasing collaboration, and fostering innovation. The Executive Director of REF submitted a Request for Partnership …

Elements Of A Talent Information System For The Shenandoah Valley Partnership, Jake Thompson

Master of Urban and Regional Planning Capstone Projects

This study examines the development of a comprehensive talent information system for the Shenandoah Valley Partnership (SVP), addressing the region’s prioritized need for talent attraction and retention. Through a mixed-methods approach combining literature review, demographic analysis, and qualitative interviews with comparable regional economic development organizations, the research identifies effective strategies for collecting, managing, and analyzing workforce data. The Shenandoah Valley region, comprising twelve localities in Virginia, faces challenges in educational attainment and healthcare provision despite possessing significant natural and cultural assets. Findings reveal three key components for effective talent information systems: (1) ambassador programs that provide qualitative insights on regional …

Navigating Preservation And Memorialization In Contested Spaces: A Case Study Of The Richmond Community Hospital And The Legacy Of Sarah Garland Boyd Jones, Rebecca M. Skatoff

Master of Urban and Regional Planning Capstone Projects

This plan develops a strategic framework to address the complexity of navigating preservation and memorialization in contested spaces, using the Richmond Community Hospital as a case study. Rooted in the legacy of Sarah Garland Boyd Jones, the first African American woman certified to practice medicine in Virginia, this plan examines the intersection of racial equity, cultural heritage, and land-use planning. The Richmond Community Hospital case study raises broader questions about how African American cultural heritage sites are preserved to confront erasure, ensure an accurate historical record, and promote historical literacy for current and future generations. Conducted with reflective practice, this …

Master Of Social Work Portfolio: Rooted In Community, Whitney Wb Pratt

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Master Of Social Work: Portfolio, Beth Alma Krueger

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The MSW portfolio comprises a comprehensive professional portfolio developed during the pursuit of a Master of Social Work (MSW) degree. The content reflects academic and field experiences structured around core social work competencies established by the Council on Social Work Education (CSWE). These competencies include ethical and professional behavior, engagement with diversity and difference, advancement of human rights and social, economic, and environmental justice, practice-informed research, and policy practice.

The document includes personal reflections, case narratives, and analyses demonstrating the integration of theoretical knowledge with practical skills in a variety of settings, including internships and community-based programs. Specific attention is …

Cultivating A Community-Based Food System In Western Montana, Elaina Lamphere

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Exploring The Stem Career Identity Development Of Black Women Across Their Lifespan, Veronica Hurd

Theses and Dissertations

Although STEM is the fastest-growing career sector, Black women are grossly underrepresented as they account for 2.5% of the workforce. Research highlights that this underrepresentation is due to racialized structures in K-12, postsecondary, and career settings that restrict Black girls’ and women’s STEM opportunities. While macrosystems such as hegemonic ideologies, attitudes, and social conditions shape Black girls’ and women’s opportunities in STEM, they continue to persist and achieve their career goals. To explore these barriers and Black women’s persistence in this industry, this study draws from the autobiographical memories of 10 Black women in the field or formerly in the …

Multitask Learning For Named Entity Recognition And Relationship Extraction, Adrienne D. Hembrick

Theses and Dissertations

Information Extraction (IE) is a fundamental task in Natural Language Processing (NLP), involving the identification of structured information from unstructured text. Two core components of IE—Named Entity Recognition (NER) and Relation Extraction (RE)—are widely used to extract key concepts and the relationships between them across various domains. However, the sequential dependency of RE on the output of NER makes it vulnerable to error propagation: inaccuracies in entity recognition can negatively affect downstream relation extraction.

To mitigate this issue, Multitask Learning (MTL) has been proposed as an approach that jointly models NER and RE, aiming to improve overall performance and reduce …

Expanding The Performance And Functionality Of Air-Jet Dry Powder Inhalers Across Multiple Applications, Ghali H. Aladwani

Theses and Dissertations

This dissertation aims to expand the performance and functionality of air-jet dry powder inhaler (DPI) applications through the development of a next-generation, mesh-nebulizer-based, and scalable spray dryer for the production of pharmaceutical aerosols, along with new spray-dried formulation production methods, novel formulations, and new air-jet DPI components for aerosol delivery to both infants and adults. The first aim focused on the development of a custom small-particle spray drying system capable of integrating vibrating mesh nebulizer technologies in various configurations for the production of excipient enhanced growth (EEG) formulations. This flexible system enabled efficient production of both small- and large-particle powders …

The Influence Of The Covid-19 Pandemic On Student Engagement At A Historically Black University, John C. Travis

Theses and Dissertations

This study examined student engagement across three NSSE administrations at an HBCU—pre-COVID (2018), during COVID (2019), and post-COVID (2022). Engagement was analyzed across four themes: Academic Challenge, Learning with Peers, Experiences with Faculty, and Campus Environment. Results showed that Learning with Peers declined significantly over time, with the largest drop between 2018 and 2022, reflecting pandemic-related disruptions to peer interaction. No significant year effects emerged for the other themes. Two-way MANOVAs indicated that gender, first-generation status, and major did not significantly predict engagement, nor did they interact with year. In contrast, classification emerged as the most consistent predictor, with upper-division …

Examining The Biotic And Abiotic Degradation Of Simple Phenols, Madeline Gruenberg

Browse all Theses and Dissertations

Plant secondary metabolites are a diverse class of compounds that encompass small phenols to large polymeric structures such as tannins. Smaller compounds such as phenolic acids can serve as substrates for soil microbes and enzymes. We monitored the degradation of three small phenols pyrogallol, gallic acid, and benzoic acid in biotic and abiotic conditions. They were chosen to observe the impacts of specific functional groups on both degradation processes and act as model compounds to mimic larger tannin reactivity. Both abiotic and biotic degradation of pyrogallol resulted in the formation of a stable quinone, while abiotic degradation of gallic acid …

The Circadian Modulating Drug Sr8278 Slows Cell Proliferation Independent Of Rev-Erbs, Ushaswini Atluri

Browse all Theses and Dissertations

The small molecule compound SR8278 was initially identified as an antagonist of the REV-ERB proteins, which play an important role in regulating circadian rhythms. Furthermore, the use of SR8278 in preclinical models has been demonstrated to ameliorate a variety of different pathologies. Using RNA-seq analysis of HaCaT keratinocytes treated with SR8278, our laboratory found that SR8278 induces a down regulation of genes involved in the G1/S phase transition of the cell cycle and an up regulation of genes involved in cholesterol biosynthesis. RT-qPCR and western blot analyses confirmed that SR8278 treatment led to lower expression of several factors involved in …

Enhanced Diagnostics And Surveillance Of Enteroviruses Including Serotypes Associated With Acute Flaccid Myelitis, Denise Lynette Kramer

Browse all Theses and Dissertations

Prior to 2014, Enterovirus D68 infections typically caused symptoms resembling the common cold. From 2014-2018, D68 was associated with an increase in acute flaccid myelitis. However, since 2020, neurological complications have all but disappeared. We selected 1076 respiratory specimens previously determined to be positive for rhinovirus or enterovirus from Department of Defense members and their beneficiaries collected globally from October 2018 through January 2024 and underwent sequencing. Of these specimens, 93.7% were identified as rhinoviruses, while 6.3% were enteroviruses, including 30 enterovirus D68. We utilized the Nextstrain bioinformatic pipeline to reconstruct the phylogenetic relationship of these 30 D68 viruses. Twenty-two …

The Role Of Rad51 And Its Paralogs In Dna Damage Response In Quiescent Cells Exposed To Solar Simulating Uv Radiation, Angitha Radhakrishnan Nair

Browse all Theses and Dissertations

Rad51, and its five paralog proteins Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3, are crucial in homologous recombination (HR) repair of DNA double-strand breaks. Prior studies have extensively shown the roles of Rad51 in the S/G2 phase, but its role in the G0/G1 phase is still unclear. Our lab focuses on studying the role of Rad51 and its paralogs in quiescent cells. RT-qPCR and western blots helped us understand the expression of Rad51 paralogs in proliferating and quiescent keratinocyte cells. Using a pharmacological inhibitor of Rad51, we found that Rad51 promotes quiescent cell survival after exposure to UV radiation. Like Rad51, …

Inclusive Approaches To Teaching African American History Rooted In Decolonial Pedagogy And Praxis, Anya Tassy

Browse all Theses and Dissertations

This thesis critically examines the exclusion of LGBTQ+ and disabled voices in African American history curricula at predominantly white institutions (PWIs) in Ohio, advocating for a decolonial pedagogical approach that centers intersectional narratives. By analyzing course descriptions, syllabi, and faculty communications from PWIs such as Wright State University, it reveals a pervasive omission of queer and disabled Black experiences, reinforcing a narrow historical lens. The study proposes a 15-week, praxis-based syllabus that integrates critical pedagogy, intersectionality, queer and disability theory, and service learning to foster inclusive historical engagement. Using primary and secondary sources, multimedia, and community partnerships, the curriculum emphasizes …

Burning Up And Burned Out: Examining Burnout In Human Services Employees, Chloe A. Bell

Browse all Theses and Dissertations

Burnout is a prevalent and critical condition experienced among human services employees. This study examined the roles of gender, parental status, and perceived organizational support (POS) as moderating factors in the relationship between stress and burnout in human services employees. A sample of full-time human services employees (N = 303) completed a survey containing assessments measuring burnout, stress, POS, and neuroticism. The results of this study indicated that POS significantly moderated the stressburnout relationship, such that greater reported levels of POS weakened the relationship between stress and burnout. However, neither gender nor parental status was found to significantly moderate the …

Comparative Impact Of Canagliflozin Versus Pioglitazone On Biomarkers Of Diabetic Kidney Disease In Db/Db Mice, Siri Chandana Minikuri

Browse all Theses and Dissertations

Diabetes mellitus is a leading cause of chronic kidney disease (CKD), primarily through dysregulation of the renin-angiotensin system (RAS), characterized by elevated Ang II which promotes vasoconstriction, oxidative stress, and renal fibrosis, along with increased urinary shedding of angiotensin converting enzyme 2 (ACE2), which can exacerbate the imbalance of RAS and tubular injury. Previous studies demonstrated that rosiglitazone, a PPAR-γ agonist, attenuated hyperglycemia, glycosuria, albuminuria, and decreased urinary ACE2 shedding in db/db mice, suggesting a RAS-mediated renoprotective mechanism. Building on this evidence, the current study compared the renal effects of pioglitazone (a PPAR-γ agonist) and canagliflozin (an SGLT2 inhibitor) in …