Digital Commons Network^™

Characterization Of Methodological Variability In Compound Specific Isotope Analysis Of Amino Acids (Csia-Aa), Audreyana Brown-Nash

Open Access Dissertations

The use of isotopes in the natural sciences stems from the principle that chemical reactions predictably alter the isotopic composition of a given sample. Recent advances in compound specific isotope analysis of amino acids (CSIA-AA) have paved the way for studies of increasingly complex ecological relationships, including the identification and characterization of organismal physiology, consumer-resource linkages, biogeochemical cycling, and movement ecology. The analytical power of CSIA-AA has caused an exponential increase in the number of application-based studies since its inception in the 1990s. With the technique constantly evolving to accommodate new research goals, it is important to understand how variation …

Intersections Of Inattention: A Qualitative Inquiry Into The Experiences Of Multiply Marginalized Students In Community College Settings, Jana N. Knibb

Open Access Dissertations

Educational research has examined the impact of expanded access to higher education for historically marginalized groups. However, research on the experiences of students who are both racially minoritized and dis/abled is limited. Findings suggest that, due to their intersectional identities, multiply marginalized dis/abled students (MMDS) navigate policies and practices related to racist ableism, which further marginalize them and create additional barriers in their higher education experiences. Expanding this research requires theoretical frameworks that account for students' identities, experiences, and barriers in higher educational spaces and contexts. This qualitative study, grounded in Dis/ability Studies and Critical Race Theory in Education (DisCrit), …

Per- And Polyfluoroalkyl Substances (Pfas) Effects On Tissue Disposition, Proteome, And Health Effects, Juliana Agudelo Areiza

Open Access Dissertations

Per- and polyfluoroalkyl substances are a class of nonbiodegradable synthetic aliphatic environmental toxicants that are ubiquitous in the environment. A small subset, specifically perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), have been designated as highly hazardous to human health by the Environmental Protection Agency (EPA) under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). PFOA and PFOS-associated adverse health effects include, but are not limited to, immune suppression, thyroid dysfunction, increased serum cholesterol, liver damage (i.e., alanine aminotransferase (ALT)), and developmental toxicity (i.e., low fetal birth weight and neurotoxicity). In this doctoral dissertation, it was hypothesized that environmental PFAS …

Real-World Clinical And Cost Effectiveness Of Osteoporotic Treatments In Men, Yu Ren

Open Access Dissertations

Osteoporosis is a condition characterized by the loss of bone mass, which increases the risk of fractures. In 2017-2018, the age-adjusted prevalence of osteoporosis among adults aged 50 and over was 12.6%, with 19.6% in women and 4.4% in men. Untreated osteoporosis can lead to a cycle of recurrent fractures that severely impact quality of life and place significant emotional, physical, and financial strain on patients, families, and healthcare resources. Approximately 50% of women and 20% of men will experience at least one fracture in their lifetime. In the United States, an estimated 1.5 million osteoporotic fractures occur each year, …

Essays On Human Decisions Related To Water Quality Problems In The United States, Sonia M. Refulio Coronado

Open Access Dissertations

Water pollution remains a pervasive and inequitable environmental threat in the United States, with mounting evidence that its burdens - whether in recreational or drinking water contexts - are unevenly distributed across communities. Urbanization, aging infrastructure, and industrial contamination have degraded both coastal waters and drinking water systems, posing serious public health and welfare concerns. At the same time, the extent to which water quality influences behavioral decisions, such as beach recreation or household adoption of water filters, remains poorly understood. Although drinking water pollution is widely ranked as a top environmental concern in national surveys, public knowledge of specific …

A Socio-Ecological Investigation Of Ulithian Spearfishing, Joshua Pi

Open Access Dissertations

Coral reef socio-ecological systems (SESs) characterize the interconnected relationships between coral reef ecosystems and reef-dependent communities. One such SES exists in Ulithi Atoll, Federated States of Micronesia, where Ulithians fish, steward, and govern their reefs through customary marine tenure, traditional ecological knowledge, and cultural taboos. In recent decades, rapid modernization in Ulithi has introduced new fishing technologies, transformed fishing practices, and ultimately reshaped the functioning of Ulithi’s traditional SES. One significant change was the introduction of spearfishing during the mid-20^th century, which is more selective and individualistic compared to other community-centric fishing methods that have existed for generations. This …

Will I Go To My Appointment? Case Management And Environmental Drivers Of Missed Transportation In Medicaid, Mark Donald Kraics

Open Access Dissertations

This dissertation examines the behavioral, clinical, and operational drivers of chronic missed appointments within Medicaid non-emergency medical transportation (NEMT) systems. Chronic member no-shows undermine care adherence and introduce operational inefficiencies across Medicaid delivery systems. This two-phased quantitative retrospective cohort study used statewide Rhode Island Medicaid data from 2020 to 2024 to evaluate whether environmental factors (e.g., weather, daylight) influence member missed trips and whether targeted managed care case management interventions reduce no-show rates among high-acuity Medicaid beneficiaries.

Phase I employed a correlational design to assess relationships between monthly environmental conditions and appointment adherence by clinical condition. Results showed no significant …

The Predictive Validity Of Implicit, Explicit, And Subtle Racism Measures On Nonverbal Behavior And Explicit Evaluations Of Black And White Women Interviewers, Adele E. Weaver

Open Access Dissertations

Statement of the Problem: A long-standing history of the oppression of Black Americans has resulted in racism manifesting through White individuals’ nonverbal behavior in interracial interactions’ specifically by way of unfriendly behavioral cues, or on the other end of the spectrum, overly positive and patronizing nonverbal behavior. Regardless of the underlying sentiment, White people’s nonverbal behavior in interracial interactions affect Black people’s mental and physical health and longevity. However, there is a dearth of research on how well-established measures of implicit and explicit racism predict racist nonverbal behavior, and even more so for subtle self-report measures. Methodology: To this …

“What’S Supp” Developing An In Vitro Model For Healthy Oral Biofilms, Alex Labossiere

Open Access Dissertations

The study of oral plaque has largely been influenced by the study of pathogens. Here in Chapter 1, I will discuss how this pathogenic focus has been dominant until the onset of microbiome research and begin to explain microbiomes in the context of supragingival plaque in homeostatic communities. From there we will then discuss the possible roots where dysbiosis may arise from plaque to cause disease and ways in which we can study healthy supragingival plaque by in vitro models.

In chapter 2, I will discuss molecular commensalism and how it can be viewed as a tool to further understand …

"Understanding Obesity Experiences And Treatment Decision-Making In Hispanic-Latino Communities”, Viviane Fornasaro-Donahue

Open Access Dissertations

Obesity disproportionately affects Hispanic-Latino adults in the United States, yet rates of metabolic and bariatric surgery (MBS) remain lower in this population compared with non-Hispanic White adults. This dissertation comprises three interconnected phases aimed to (I) explore perceptions of obesity, obesity treatment, and patient-provider communication, (II) inform the development of a culturally responsive bilingual educational material about obesity and MBS, and (III) evaluate its acceptability among Hispanic-Latinos adults with obesity.

Phase I involved a qualitative exploration using semi-structured interviews with Hispanic-Latino adults (n=26) recruited from a community and a clinical MBS setting. These interviews explored participants’ perceptions of …

Ischemia-Induced Cytoskeletal And Nuclear Disruptions Drive Neuronal Death And Dysfunction: Insights Into The Connection Between Stroke And Dementia From In Vitro And In Vivo Models Of Stroke, Emily Potts

Open Access Dissertations

Stroke and Alzheimer’s disease and related dementias (ADRD) represent two of the leading causes of neurological disability worldwide, and their prevalence is expected to rise as the global population ages. Although stroke is traditionally viewed as an acute vascular event, a growing body of evidence suggests that transient ischemic injury can trigger lasting cellular disturbances that increase neuronal vulnerability to later neurodegeneration. Understanding how ischemic stress alters neuronal structure and function, and how these changes may overlap with pathways implicated in ADRD, is an emerging focus for stroke and neurodegenerative researchers. This dissertation addresses these questions through an integrated combination …

Coastal Perspectives: An Analysis Of Resident And Visitor Attitudes And Motivations Of Coastal Resilience Measures In Rhode Island, Jamie-Lynn Ward

Open Access Master's Theses

Anthropogenic impacts of climate change negatively affect the geographic structure, economic stability, and environmental conservation of coastal communities at exhaustive rates. Coastal resiliency planning and frameworks have been widely credited and criticized for their ability to mitigate climate risks in vulnerable communities. Yet, the rapid impacts of climate on communities' socioeconomic and environmental sectors have led to outcries from researchers and users for integrated and holistic coastal resilience approaches. Approaches highlighting stakeholders’ views of risks, coastal resilience measures, and place values to form localized adaptation and politically supported management strategies directly involving and benefiting communities. This mixed-method study was designed …

Nanotube Spectral Fingerprinting And Machine Learning For Optimized Bioimaging/Sensing And Disease Detection Applications In Als, Rodrigo Monroy Lopez

Open Access Master's Theses

Single-walled carbon nanotubes (SWCNTs) possess unique physicochemical and optical properties that make them ideal candidates for biomedical imaging, biosensing, and disease diagnostics. This thesis explores the potential of SWCNT-based spectral fingerprinting combined with ML (Machine Learning) algorithms to optimize bioimaging, disease detection and prediction, with a specific focus on differentiating between healthy and amyotrophic lateral sclerosis (ALS) lymphoblastic patient samples. By functionalizing SWCNTs with single-stranded DNA, we enhance their stability and target specificity, enabling their application in serum patient samples.

A comprehensive spectral analysis of DNA-SWCNTs was conducted using near-infrared fluorescence spectroscopy and other characterization techniques, including UV-Vis-absorption spectroscopy. The …

The P3 Event-Related Potential (Erp) In Visual And Auditory Tasks: Implications For Executive Functioning In Adhd Preadolescent Children, Alex Visal Seng

Open Access Master's Theses

Attention-Deficit/Hyperactivity Disorder (ADHD) is a widespread psychological disorder in children, poorly impacting executive functioning domains of inhibitory control and working memory. Event-related potentials (ERPs) provide neuroelectric insight into these cognitive processes. However, most ERP research focuses on one task type, limiting direct comparisons of cognitive demands across different task paradigms. This study examined P3 amplitude and latency in ADHD children using a visual NoGo task (response inhibition) and an auditory oddball task (working memory), and associations between the P3 ERP and behavioral measures of executive functions.

Cross-sectional data of symptomatic ADHD children (N=13; F=5; aged 9.15 ± 1.86 years) were …

Big Cells, Big Impact: Unravelling Seasonal Patterns Of Net Primary Production In Narragansett Bay, Dominique Jae Lockwood

Open Access Master's Theses

Net primary production is a measurement of available energy, or the amount of biomass that phytoplankton produce during photosynthesis that fuels marine food webs and drives carbon cycling. Despite its ecological importance, net primary production is relatively understudied in comparison to chlorophyll-a, which is often used as a proxy for biomass rather than productivity. In this study, we measured size-fractionated net primary production and chlorophyll-a concentrations in Narragansett Bay over a 14-month period from January 2022 to February 2023. Weekly surface water samples were collected and filtered to distinguish between small (> 10 μm) and large ( …

The Anatomy Of Efficiency: Changes In British Military Medicine On The Western Front, 1914-1918, Ricky Mather

Open Access Master's Theses

The Western Front of the First World War was a theater of tragedy and unprecedented loss. As thousands of mangled British bodies were evacuated from the front lines, medical officers, surgeons, nurses, orderlies, stretcher-bearers, and other staff worked tirelessly in an efficient and technical manner to restore soldiers’ fitness so they might be redeployed into the chaos, and continue servicing the war machine. This thesis looks at changes in medicine driven by the war. First, it examines the evolution of medical theory and practice as reflected in three medical manuals. The first was published in 1911, before the war, and …

The Impact Of Urbanization On Water Scarcity And Waterborne Diseases In Eastern Africa: A Case Study Of Nairobi, Lucy N. Kamau

Open Access Master's Theses

Urbanization in Eastern African cities has rapidly accelerated, placing immense strain on existing water infrastructure and sanitation systems. In Nairobi, this has resulted in spatial disparities in access to clean water and heightened vulnerability to waterborne disease risks. The study aimed to (1) assess the impact of urbanization on water scarcity and waterborne diseases in Nairobi using geospatial analysis and remote sensing (2) quantify urbanization trends 1999–2024 (3) identify spatio-temporal water scarcity hotspots for the years 2019 and 2024 (4) model waterborne disease risk maps for 2019 and 2024 (5) Overlay disease risk map with hospitals. To quantify urbanization for …

Analysis Of The Utilization Of Vegfinhibitors In Rhode Island And In Medicare Part B Nationally, Kevin Izzio

Open Access Master's Theses

Statement of the Problem: Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are leading causes of blindness and low vision in the United States. In 2019, approximately 19.8 million Americans were living with AMD, which is classified into dry (non-neovascular) and wet (neovascular) forms, with the latter being more severe. DR, a complication of diabetes, affected an estimated 9.6 million Americans in 2021, with progression leading to proliferative DR (PDR) and diabetic macular edema (DME), both of which can cause vision loss. Vascular endothelial growth factor (VEGF) inhibitors are the standard treatment for these retinal diseases, targeting abnormal angiogenesis …

Navigating Online Perceptions Of Offshore Wind On Social Media: Facebook Discussions On Recent Whale Strandings, Giselle Hausmann

Open Access Master's Theses

The Biden-Harris administration implemented a goal to achieve 30 GW of offshore wind energy by 2030 (US Department of Interior, 2021). The rapid increase in offshore wind activity on the East Coast, combined with NOAA’s declared unusual mortality event in 2016/2017, has sparked a discussion about offshore wind being a potential cause of whale deaths. This paper aims to analyze the discourse on offshore wind and whales through a content analysis of Facebook comments. Facebook pages from Massachusetts (The New England Aquarium), Rhode Island (Rhode Island DEM), New York (The Atlantic Marine Conservation Society), New Jersey (Marine Mammal Stranding Center), …

A Mixed Methods Approach To Improve Understanding Of Marine Plastic Debris In Rhode Island, Georgia Cheney

Open Access Master's Theses

The marine plastic debris problem, brought to people's attention in the 1970s, has been a growing environmental challenge. It is estimated today that society produces 400 million tonnes of plastic every year. Of the plastic produced, only a small percentage of the plastic is successfully recycled and reused. It is important to better understand people's perceptions of marine plastic debris, so policy makers can better define the problem, develop effective policies, and gain policy support. This study aims to fill a gap in knowledge around Rhode Islander’s perceptions of the marine plastic debris problem.

Risk Factors For Autism Spectrum Disorder: A Statistical And Machine Learning Perspective, Supti Biswas

Open Access Master's Theses

his study explores factors associated with autism spectrum disorder (ASD) through analysis of a rich dataset comprising maternal and child characteristics. The data were carefully cleaned and preprocessed to address missing values and ensure analytical consistency. Statistical analyses and advanced visualization techniques were used to uncover patterns linking ASD status with variables such as maternal age, prenatal smoking, and education level. To further assess predictive capacity and feature importance, multiple supervised machine learning algorithms - logistic regression, decision trees, random forests, and support vector machines (SVM) - were applied. ASD appears to be influenced by a complex interplay of demographic …

The Bodhi App: A Post-Trauma Self-Regulation App For People With Intellectual And Developmental Disabilities, Liam Cannon

Open Access Master's Theses

People in the United States living with intellectual and developmental disabilities (I/DD) often experience trauma at a disproportionate rate. Due to societal and personal barriers, individuals with I/DD have problems with gaining access to therapy, thus often having to live with the negative effects of their untreated trauma. The effects of untreated trauma can cause severe impairment which affects a person’s quality of life and emotional, social, and physical development.

Post-trauma self-regulation is a way of doing activities to regulate one’s emotions to help cope with the negative effects of trauma. It has been shown as an effective method of …

From Lawns To Life: Landscaping For Biodiversity On Mason’S Island, Margit Burgess

Open Access Master's Theses

The collapse of biodiversity is an existential threat to life on Earth. Residential landscapes, dominated by open lawns maintained in turfgrass, do not support biodiversity. In the United States, turfgrass has replaced native landscapes in over 40 million acres, with 500 square miles added each year (Tallamy, 2019). Of the 78% of the U.S. land that is privately owned, approximately 135 million acres - nearly twice the size of all national parks combined - are residential (Milesi et al., 2005). With a shift in private landscape management, this land could present a largely untapped opportunity for biodiversity restoration and social …

Best Methods For Establishment And Maintenance Of Pollinator Plantings In Highway Rights-Of-Way, Sophia Lopardo

Open Access Master's Theses

This study explores the potential of highway rights-of-way (ROWs) to serve as habitats for native New England grasses and flowering plants, while also enhancing resources essential for native pollinator communities. This project emphasizes the adaptability of regionally native and insect-pollinated wildflowers and grasses to periodically mowed ROWs; the research assesses various establishment methods that are commonly used in new roadside construction. The study aims to evaluate the effectiveness of different establishment methods for developing roadside pollinator meadows within ROW settings, using species richness (separated into forbs, grasses, insect pollinated functional groups), bare ground percentage, and seed mix germination and persistence …

Micro- And Nano-Plastics Preparation And Their Impact On Cobetia Marina, Lauren Lamothe

Open Access Master's Theses

Plastic pollution has become an increasing threat to marine and coastal environments. Macroplastics derived from consumer waste are broken down by chemical and physical degradation processes, resulting in micro- and nano-plastics (MPs and NPs). This thesis presents an investigation into the MP and NP pollution in the sea surface microlayer (SSML). The SSML contains surface active compounds and natural and anthropogenic matter. This study provides insight into the deeper impacts on the transport and fate of MPs and NPs and on marine bacteria. The first chapter works through the breakdown of plastic particles with the use of a top-down approach …

Plastics And Their Interactions With Bacterial Biofilms Of Synechococcus Sp. Pcc 7002 And Escherichia Coli Nissle 1917, Jackson Zmich

Open Access Master's Theses

Plastic waste is a leading global pollutant with increasing concerns, as recent studies have shown that these wastes are not only concentrated on a macro scale but on a micro and nano scale. These micro- and nano- sized plastic particles, denoted as MPs and NPs, have been measured in marine and freshwater sources, air, food products, and within biosolids expelled from organisms, including humans. Due to their small size, MNPs are entering organisms through inhalation, ingestion, or dermal absorption. [1] Humans are ingesting MNPs daily, with median rates of approximately 200 ng/capita/day for children and 600 ng/capita/day for adults. [2] …

Little Problems: Photosynthetic Textile Treatments As A Source Of Oxygen, Morgan Campbell

Open Access Master's Theses

During human space travel, oxygen (O2) must be stored and carried aboard the shuttle for the entire journey; compressed O2 is highly flammable and combustible, thus doing so puts the crew’s lives at risk in the event of a fire (Mandel, 2019). By creating O2 onsite, the necessity of compressed O2 canisters and the associated risks can be reduced or erased entirely. Photosynthesis, the process through which plants convert atmospheric carbon dioxide (CO2) into O2, is one method of creating O2 (Lorch, 2020). The National Aeronautics and Space Administration (NASA) has experimented with photosynthetic O2 systems since its inception but …

Assisted Living, Residential Care, And Memory Care Staffing Level Dynamics: Oregon, 2017–2023, Sarah Dys, Ozcan Tunalilar

Institute on Aging Publications

Objectives

To examine changes in staffing levels over time in Oregon assisted living and residential care (AL/RC) communities between 2017 and 2023.

Design

Longitudinal study of licensed AL/RC communities.

Setting and Participants

A total of 1720 setting-year observations from 535 individual AL/RC communities in Oregon between 2017 and 2023.

Methods

Primary data were collected through the Oregon Community-Based Care (CBC) study. Staffing levels were estimated as care staff hours per resident per day and reported overall and by staff type, including registered nurses, licensed practical nurses, certified nursing assistants, certified medication aides, unlicensed care staff, life enrichment staff, and social …

Week 96 Results Of Bictegravir/Emtricitabine/Tenofovir Alafenamide For Hiv Treatment In People With Substance Use Disorders, Joshua P. Havens, Sara Bares, Elizabeth Lyden, Nada A. Fadul, Susan Swindells

Journal Articles: Infectious Diseases

BACKGROUND: The BASE study (NCT03998176), a phase 4, 48-week (W), single-arm, prospective trial, revealed that the use of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in people with HIV and substance use disorders (PWH/SUD) was safe and effective without emergent antiretroviral resistance despite incomplete adherence. Here, we present the W96 results.

METHODS: A retrospective analysis of all participants enrolled in the BASE study was completed from W48 to W96. End points of interest at W96 included the proportion of participants with viral suppression (VS; HIV RNA < 50 copies/mL [c/mL]), incidence of protocol-defined virologic failure (PDVF; 2 consecutive ≥400 c/mL), safety, adherence (percentage of days covered [PDC]), retention in care, and prevalence of ongoing substance use.

RESULTS: All enrolled BASE participants (n = 43) were included in the W96 analysis. At W48, 21 participants …

Preferences And Feasibility Of Long-Acting Technologies For The Treatment Of Hepatitis C Virus: A Survey Of Patients In Diverse Low- And Middle-Income Countries, Renae Furl, Kimberly Scarsi, Harlan Sayles, Matt Anderson, Joelle Dountio Ofimboudem, Ethel D. Weld, Imam Waked, Asmaa Gomaa, Alzhraa Al-Khatib, Fatma Mohammed Elshobary, Hailemichael Desalegn, Henok Fisseha, Sunil Solomon, Shruti Mehta, Andrew Owen, Steve Rannard, David L. Thomas, Susan Swindells

Journal Articles: Infectious Diseases

Despite available curative treatments, global rates of hepatitis C virus (HCV) infection persist with significant burden in low- and middle-income countries (LMICs). Long-acting (LA) antiviral products are in development. This study explored the challenges and opportunities in LA-HCV treatment across three LMICs: Egypt, Ethiopia and India. The survey focused on understanding barriers and facilitators to treatment, with emphasis on LA treatment preferences. Four-hundred respondents completed a survey including demographics, HCV treatment history and preferences for injections, implants and microarray patches (MAPs) compared to pills. Overall, 78% of respondents were willing to receive injections, 43% were willing to receive implants and …