Digital Commons Network^™

Where, How, And How Much? A Multicenter Cohort Study Of The Relationship Across Lupus Decision-Aid Modality, Place Of Administration, Interruption And Viewing Completeness, And Patient-Reported Outcomes, Jasvinder A Singh, Mark Beasley, Larry R Hearld

Faculty, Staff and Students Publications

Objective: We assessed whether shared decision-making (SDM) and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE) differs by PtDA setting, modality, and the viewing experience.

Methods: Patients with SLE were invited to view a self-administered computerized SLE PtDA during regular clinic visits at 15 rheumatology clinics in an implementation trial. Patients completed a survey that included SDM measures including the decision conflict scale (DCS), Preparation for Decision Making (PDM) scale, and CollaboRATE scale, and we measured perceived patient acceptability, feasibility, and satisfaction. Patients viewed the SLE PtDA in …

Method For Generation And Ex Vivo Expansion Of Genetically Edited Mouse Tregs, Yosef Gilad, Adam M Dean, Yan Xia, Sang Jun Han, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Regulatory T cells (Tregs) play a crucial role in the immune system, and their dysfunction can lead to the development of autoimmune conditions. In cancer, tumors frequently hijack the immunosuppressive function of Tregs to evade immune responses. Due to their central role in key pathological processes, Tregs have gained increasing attention as promising targets for various clinical applications. However, their relative scarcity (∼5% to 10% of CD4+ T cells) and instability presents a technical challenge for research and therapeutic development. In congenic animal models used to investigate autologous cell transfer-based therapies, this challenge is even greater, as Treg donor animals …

Rbm8a Deficiency Causes Hematopoietic Defects By Modulating Wnt/Pcp Signaling, Agnese Kocere, Elena Chiavacci, Charlotte Soneson, Seth T Jacobson, Emma N Harrison, Kevin Manuel Méndez-Acevedo, Jacalyn S Macgowan, Harrison H Wells, Max S Hiltabidle, Azhwar Raghunath, Jordan A Shavit, Daniela Panáková, Margot L K Williams, Mark D Robinson, Christian Mosimann, Alexa Burger

Faculty, Staff and Students Publications

Thrombocytopenia-Absent Radius (TAR) syndrome is a rare congenital condition with reduced platelets, forelimb anomalies, and variable heart and kidney defects. TAR syndrome is caused by mutations in RBM8A/Y14, a component of the exon junction complex. How perturbing a general mRNA-processing factor causes the selective TAR Syndrome phenotypes remains unknown. Here, we connect zebrafish rbm8a perturbation to early hematopoietic defects via attenuated non-canonical Wnt/Planar Cell Polarity (PCP) signaling. In hypomorphic rbm8a zebrafish, we observe a reduction of cd41-positive thrombocytes. rbm8a-mutant zebrafish accumulate mRNAs with retained introns, including non-canonical Wnt/PCP pathway components resulting in convergent extension defects. We found that reduced rbm8a …

Predictive Factors Of Academic Success During Transition To Undergraduate Studies In Stem Programs In Kansas, Elizabeth L. Butler

Electronic Theses and Dissertations

In tThis dissertation the researcher exploreds the correlations between high school GPA, ACT Math, ACT cComposite scores, and first -semester GPA for first-time freshmen at a mid-sized university in the Midwest. This quantitative correlational study uses multiple regression analysis to discover correlations that may exist between these interval variables. Data for this study was collected through a request to the study site’s oOffice of pPlanning and aAnalysiss at the university and was all archival data at a record level for the students. Data had been collected through the admissions process and was stored in Banner and SLATE, both data management …

The Impact Of Career Development Education In Rural Communities: A Program Evaluation, Hayden S. Austin

Electronic Theses and Dissertations

This study examined the impact of a regional career development education program using a post-test-only, exploratory descriptive design with middle and high school students from rural and urban school districts in West Central Texas. Students who participated in the Career and Education Outreach (CEO) program received four classroom sessions focused on labor market information, high-demand industries, employability skills, and career pathways. The purpose of this research was to explore whether students’ perceptions of the value of career development education differed based on geographic region, economic level, educational level, ethnic composition of the district, and the students’ own demographic characteristics. A …

Principals’ Perceptions Of Their Preparedness To Facilitate And Support Technology Integration In Schools: A Case Study Of Four Rural Texas Principals, Christina J. Campbell Ed.D.

Electronic Theses and Dissertations

School administrators face the challenge of leading technology integration that provides meaningful learning opportunities to prepare students for 21st-century skills and careers. Research has shown that administrative leadership support, behaviors, assumptions, and policies impact technology integration in the classroom. The International Society for Technology in Education (ISTE) standards include guidelines for education leaders and their role in supporting educators using technology. However, leaders underestimate the impact of their leadership on effective use in the classroom. The purpose of this qualitative case study was to explore the perceptions of South Texas rural public school principals working in Chapman Independent School District …

Consequences Of Secondary Traumatic Stress On Individuals Without Formal Psychological Training Working With Trauma-Exposed Children, Juan F. Valdez

Electronic Theses and Dissertations

Literature has suggested that secondary traumatic stress could cause various adverse effects for individuals working with trauma-exposed populations. However, direct care workers performing in shelters designed to serve unaccompanied immigrant children are faced with the task of caring for these minors who may have been exposed to trauma in their home countries, while traveling to the United States, or after arriving in the country. This qualitative case study was conducted to understand and describe the experiences of 15 current employees and five ex-employees who have worked with unaccompanied children for at least a year. These individuals participated in in-depth personal …

Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite A Normal Audiogram? A Systematic Review And Meta-Analysis, Sajana Aryal, Monica Trevino, Hansapani Rodrigo, Srikanta K. Mishra

School of Mathematical & Statistical Sciences Faculty Publications

Understanding the initial signature of noise-induced auditory damage remains a significant priority. Animal models suggest the cochlear base is particularly vulnerable to noise, raising the possibility that early-stage noise exposure could be linked to basal cochlear dysfunction, even when thresholds at 0.25-8 kHz are normal. To investigate this in humans, we conducted a meta-analysis following a systematic review, examining the association between noise exposure and hearing in frequencies from 9 to 20 kHz as a marker for basal cochlear dysfunction. Systematic review and meta-analysis followed PRISMA guidelines and the PICOS framework. Studies on noise exposure and hearing in the 9 …

Common Severity-Based Definitions Of Bronchopulmonary Dysplasia Are Not Associated With Outpatient Morbidities, Robin L Mckinney, Antonia P Popova, Milenka Cuevas Guaman, Matthew J Kielt, Paul E Moore, Sharon A Mcgrath-Morrow, Joseph M Collaco

Faculty, Staff and Students Publications

Objectives: Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, which can have life-long effects. Commonly used definitions of BPD severity are based on respiratory support at 36 weeks post-menstrual age. The utility of these definitions for tertiary referral centers outside the initial birth hospitalization is unclear.

Study design: Retrospective cohort study of infants born < 34 weeks gestation in the BPD Collaborative registry using three common definitions of BPD severity at 36 weeks post menstrual age and associated their severity with outpatient respiratory outcomes during the first 3 years of life.

Results: BPD severity by all three definitions was applied to 608 patients. Although the definitions had different distributions of BPD severity for the cohort, a majority of participants (75.7%) had moderate/Grade 2 or severe/Grade 3 BPD irrespective of the definition. Using clustered logistic …

Racial And Ethnic Disparities In Pediatric Autoimmune Encephalitis: A Systematic Review, Jennifer H Yang, Kristen S Fisher, Julia Dumcum, Sophie Zacharek, Alexandra B Kornbluh, Kelsey Poisson, Mary C Karalius, Leigh Sepeta

Faculty, Staff and Students Publications

Objectives: Health disparities and social determinants of health are increasingly recognized as important predictors for clinical outcomes in autoimmune disease. However, this is poorly studied in pediatric autoimmune encephalitis (AE).

Methods: We conducted a systematic literature review in accordance with PRISMA guidelines. Searches included Medline (Pubmed), EMBASE, and Web of Science databases from inception years to October 4, 2024. Inclusion criteria were: 1) Patients diagnosed with AE ≤ 18 years old; 2) any report of race and/or ethnicity, 3) report of specific diagnostics and disease outcomes, 4) observational cohort studies, epidemiological studies or case series/ cohort studies of n ≥ …

Acculturation, Values, And Acculturative Stress For Autistic Latino Emerging Adults And Spanish-Speaking Parents Participating In The ¡Iniciando! La Adultez Program, Antonio F. Pagán, Miriam Ortiz, Erin Bernal, Katherine A. Loveland, Ana Esparza, Cecilia Montiel-Nava, Ron Acierno

Psychological Science Faculty Publications

Latino families with emerging adults diagnosed with Autism Spectrum Disorder (ASD) face unique challenges during the transition to adulthood, influenced by cultural values, acculturation, and systemic barriers. Acculturation and acculturative stress are particularly relevant in this population, as they navigate cultural adaptation while maintaining traditional values like familismo (family) and respeto (respect). These dynamics are further complicated by disparities in access to resources and culturally responsive interventions. This study explores the interplay of cultural values, acculturation, and acculturative stress among Latino emerging adults with ASD and their Spanish-speaking parents participating in a culturally adapted and translated intervention. Using a cross-sectional …

Standard Complete Blood Count To Predict Long-Term Outcomes In Febrile Infection-Related Epilepsy Syndrome (Fires): A Multicenter Study, Martin Guillemaud, Aurélie Hanin, James J Riviello, Mario Chavez, Ayush Batra, Megan Berry, Francesca Bisulli, Carlos Castillo-Pinto, Carla Cobos-Hernandez, Sophie Demeret, Krista Eschbach, Raquel Farias-Moeller, Madeline Fields, Nicolas Gaspard, Elizabeth E Gerard, Teneille E Gofton, Margaret T Gopaul, Matthew D Gruen, Anthony D Jimenez, Karnig Kazazian, Minjee Kim, Marwa Mansour, Lara Marcuse, Clémence Marois, Mikaela Morales, Lorenzo Muccioli, Elena Pasini, Michelle M Pham, Santiago Philibert Rosas, Aaron F Struck, Nathan Torcida, Mark S Wainwright, Ji Yeoun Yoo, Eyal Muscal, Vincent Navarro, Lawrence J Hirsch, Yichen Lai

Faculty, Staff and Students Publications

Objective: We investigated whether complete blood count (CBC) analyses during intensive care unit stay could predict 12-month outcomes in patients with cryptogenic febrile infection-related epilepsy syndrome (FIRES), a subset of new-onset refractory status epilepticus (NORSE).

Methods: Outcomes at 12 months were classified as "unfavorable" (Glasgow Outcome Score [GOS] 1-3) or "favorable" (GOS 4-5). Demographic, clinical, and serial CBC data were collected across treatment phases: (1) no immunotherapy (before initiation or no treatment), (2) first-line immunotherapy, and (3) second-line immunotherapy. For each treatment phase, predictive models stratified outcomes based on CBC features using decision tree regression, with separate models for adults …

Transoral Robotic-Assisted Removal Of A Submucosal Pyriform Sinus Foreign Body, Elisabeth Wenneker, Rebecca Doctor, Ari Schuman, Adam Szymanowski, Ray Wang

Faculty, Staff and Students Publications

Background: Submucosal foreign bodies of the medial pyriform sinus represent a challenge given limited visualization and difficult retraction with endoscopic approaches, and risk of injury to the recurrent laryngeal nerve with open approaches. Transoral robotic surgery (TORS) offers improved visualization and multiple working arms to facilitate retraction. We present a novel case utilizing the Da Vinci SP system for removal of an embedded fishbone of the medial pyriform sinus.

Results: An 84-year-old woman presented with five days of odynophagia and globus sensation after swallowing a fish bone. Non-contrast computed tomography scan revealed a 3.0 cm submucosal object within the post-cricoid …

Screening For Diabetes After Solid Organ Transplantation: A 10-Year Retrospective Study, Ridwan B Ibrahim, Sneha Kumar, Sahil Malik, Joseph A Spinner, Daniel H Leung, Sridevi Devaraj

Faculty, Staff and Students Publications

Post-transplantation diabetes mellitus (PTDM) is a common and important complication after solid organ transplantation, affecting long-term outcomes. Graft rejection, decreased patient survival, infections and increased cardiovascular risk are associated with PTDM and may arise from both transplant-related and traditional risk factors. Early screening for PTDM is crucial for early detection and management. Despite clinical guidelines recommending regular screening for PTDM, screening rates remain suboptimal. This retrospective study analyzes PTDM screening rates between January 2014-January 2024 among pediatric kidney, liver, heart and lung transplant recipients at a large quaternary academic pediatric transplant center. PTDM screening rates vary by organ type, with …

Vol 70 #6, Rebecca Chavez

MPLA Newsletter

No abstract provided.

Computational Study On Protein Docking With Vascular Disease Application, Lohitha Reddy Shanigaram

Master's Theses

This thesis investigates how computational methods can help us understand protein docking and vascular diseases by integrating machine learning. The main goal of this research is to develop a system that can predict whether variants in the SOX17 gene are associated to Pulmonary Arterial Hypertension (PAH), a significant vascular condition. To do this, a dataset of 1,063 SOX17 variants was created using publicly available sources such as ClinVar, gnomAD, LOVD, and Ensembl. The study included cleaning and structuring the dataset, encoding genomic data and training a Random Forest classifier to classify variants as positive, negative, or unknown for disease association. …

The Impact Of The Covid-19 Pandemic On National Hockey League Fan Attendance, Ramon E. Rivera

Electronic Theses, Projects, and Dissertations

The COVID-19 pandemic struck swiftly around the world, causing several societal functions and normalcies to adapt or shut down completely. This culminating project explores the effects of COVID-19 on arena fan attendance of the National Hockey League (NHL). This project was guided by the following three research questions: Q1 – How did the NHL arena closures affect fan attendance during the COVID-19 pandemic? Q2 – What factors influenced NHL fan arena attendance before the start of the COVID-19 pandemic? Q3 – What factors impacted the NHL arena fan attendance after the conclusion of the COVID-19 pandemic? An empirical model developed …

Rethinking The Performance Evaluation, Jason C. Crowley

Electronic Theses, Projects, and Dissertations

This paper delves into the complexities of performance evaluations within community college settings, aiming to inform a more effective approach specific to the unique characteristics of staff attracted to this work. Grounded in the understanding of validity in psychometric measurement and management theories, it seeks to identify evaluation criteria that prioritize enhancing the working environment which is known to impact overall organizational performance over traditional results-driven metrics to measure individual staff performance. Key theoretical underpinnings include discussions on validity, highlighting that measuring validity against the underlying goal of the performance evaluation (i.e., increased organizational performance) has been largely ignored in …

Adaptive Compulsion, Amanda A. Santos

Electronic Theses, Projects, and Dissertations

Adaptive

Adjective

Adap.tive ( ə-ˈdap-tiv)

of, relating to, or being a heritable trait that serves a specific function and improves an organism's fitness or survival

Compulsion

Noun

Com.pul.sion (kəm-ˈpəl-shən)

a repetitive behavior or mental act that a person feels driven to perform to alleviate the anxiety and distress caused by an unwanted thought or urge, known as an obsession.

For years we have lived in unprecedented times. From the worldwide quarantine in 2020 resulting from the pandemic, to our current US political crisis. The constant barrage of events is overwhelming and demoralizing.

The work in this gallery is a display …

Groundwater Arsenic Contamination In The Oro Grande Wash, Dalila Boice

Electronic Theses, Projects, and Dissertations

This study investigates the distribution of naturally occurring arsenic in groundwater within the Oro Grande Wash in San Bernardino County, California. Depth-discrete groundwater quality data were collected over multiple years using nested and Westbay monitoring wells. Water quality results showed higher levels of arsenic in the deeper aquifers, ranging between 600 feet and 1,000 feet below ground surface. Arsenic levels in these regions reached as high as 66 µg/L. At roughly 800 feet and below, water quality data from the wells reveal that arsenic concentrations exceeded the 10 µg/L maximum contaminant level (MCL) in 87% of cases. These data provide …

Learning To Be Trauma-Informed: An Examination Of Individual-Level Factors Predicting Perceptions Of And Response To Trauma-Informed Practice Trainings, Kelly Daniel

Electronic Theses and Dissertations

Trauma is a substantial threat to public health. As such, significant effort has been exerted into developing interventions which mitigate the consequences of trauma. Trauma-informed practice (TIP) aims to alleviate the effects of trauma by building policies and practices focused on safety, trust, transparency, support, collaboration, and empowerment. This study investigated how individual-level factors, including readiness for organizational change, perceived benefit of TIP training, and personal trauma history affect one’s ability to apply a TIP lens in a sample (n =100) of members of a graduate-level college. Further, it explored if one’s perceptions of and response to trauma-informed practice training …

Learning To Think, Thinking To Learn: A Qualitative Investigation Of Inquiry-Based Learning And Metacognition In Preschools, Jessica Carter

Electronic Theses and Dissertations

In response to an increased focus in the field of early childhood on inquiry-based practices and metacognition, this qualitative study was designed to investigate a variety of approaches to planning and facilitating classroom inquiry. Additionally, this research was designed to discover the ways in which metacognitive strategies are used in preschool classrooms to foster the learning process. Using teacher interviews, classroom observation, and analyses of teachers’ planning documents in a multiple case study design, this study focused on five Reggio-inspired classrooms to investigate the planning and teaching practices of preschool teachers related to inquiry-based learning. Of importance was their use …

A Comparative-Correlational Study On The Mental Health And Well-Being Of First-Generation Students At A Historically Black College And University, Shedred Jackson

Electronic Theses and Dissertations

The purpose of this study was to investigate the mental health and well-being of first-generation college students (FGCS) in comparison to non-first-generation college students (NFGCS) at a private Historically Black College and University (HBCU) in the Southeast. This study was undertaken to investigate students' mental health and well-being, as well as their use of, access to, and the availability of mental health services. A comparative-correlational research design was employed to collect and analyze the data. The study used a sample size of 388 responses from undergraduate college students enrolled at the private HBCU. Of the 388 students in the sample, …

Undergraduate Students' Perceptions Of Sense Of Belonging And Engagement Opportunities In The Campus Community, Shelby Jo Akers

Electronic Theses and Dissertations

This non-experimental, correlational, quantitative study examined the relationship between undergraduate students’ perceptions of sense of belonging and their participation in university programming and engagement opportunities at a medium-sized public institution in the Southeastern United States. Guided by the Integrative Framework for Belonging (Allen et al., 2021), the study explored how specific student factors including academic major, campus residency status, class standing, primary mode of instruction, and employment status intersect with engagement to shape students’ sense of belonging. Engagement opportunities that were measured included dimensions of campus facility use and participation in clubs and organizations. Questions related to perceptions of the …

A Leslie System For A Demographic Simulation: From An Actuarial Point Of View, David Kings

Electronic Theses and Dissertations

This thesis develops a discrete stochastic linear systems interpretation of age–stage demographic evolution grounded in Leslie operators and realized in a discrete-event simulation implemented with salabim. The central claim is that one annual cycle of the simulation constitutes a cone-preserving, stochastic affine transformation on a high- dimensional population state vector indexed by age, sex, marital status, household type, employment, and education, and that the composition of yearly operators yields a random matrix product whose top Lyapunov exponent is the stochastic counterpart of the Perron–Frobenius growth rate (Caswell, 2001; Tuljapurkar, 1997)[1, 2]. The actuarial bridge is constructed by mapping simulated survival …

Perceptions Of Choral Teachers On The Characteristics Of A Secondary Choral Program, Nathan Dale Rhea

Electronic Theses and Dissertations

The purpose of this study was to examine the perceptions of choral teachers on the characteristics of a successful secondary choral program. The study focused on the main characteristics of excellence, success, and sustainability. The literature showed that there was a significant amount of research on the music curriculum, standards, and various assessment strategies but minimal research on perceptions on the characteristics of excellence, success, and sustainability of a choral music program at the secondary level.

Data collection strategies included individual interviews of eight participants who were choral music educators. The analysis of data occurred through the lens of the …

Isolation, Chemical Characterization, And In-Vitro Cytotoxic Evaluation Of Novel Polar Flavonoids From Chromolaena Leivensis, Matthew Tohatsu Tetteh

Electronic Theses and Dissertations

This study focuses on isolation, chemical characterization, and in-vitro cytotoxic evaluation of novel polar flavonoids from chromolaena leivensis. A 95% ethanolic extract of c. leivensis shipped by Prof. Ruben Torrenegra from University of Applied and Environmental Sciences, Bogota, Colombia, was dissolved in 1:1 methanol/chloroform mixture and its purity analyzed by TLC. The sample was eluted with toluene/methanol in an increasing order of polarity on silica gel, resulting in 49 fractions labelled CLA1 to CLA49. Among these fractions, CLA10 (1) and CLA19 (2) obtained yellow and white crystals. They were analyzed by GCMS, IR, and …

Comparative Value Of Echocardiography Vs. Right Heart Catheterization In Heart Failure With Preserved Ejection Fraction, Nathanael Tran, Mohammad Shaar, Hussein Al-Sudani, Ramy Sedhom, Hamza Akhtar, Kevin Bryan Lo, Gregg S. Pressman

Einstein Health Papers

BACKGROUND: Echocardiography and right heart catheterization (RHC) are useful in the evaluation of heart failure with preserved ejection fraction (HFpEF). We compared the two among decompensated HFpEF patients to determine their relative value in predicting all-cause mortality and a composite of cardiovascular (CV) death and heart failure (HF) readmission at 1 year.

METHODS: One hundred seventy-eight decompensated HFpEF patients who underwent both procedures and survived to hospital discharge were retrospectively identified. Hospital records and the National Death Index were queried to determine outcomes. Echocardiographic and invasive parameters were tested for significant associations with each outcome. Additionally, three predictive models were …

In This Issueclinical Practice Guidelinesreview Articleoriginal Articles

Saudi Medical Journal

No abstract provided.

Interventional Study Of The Iselfie Heart Health Tool For Assessment Of Vital Signs (Heart Rate, Blood Pressure, And Oxygen Saturation) In The Kingdom Of Saudi Arabia, Abdulaziz S. Alhomod, Demah Abdulaziz Almowanes, Robert Scooter Plowman, Azhar Quddus, Hassan Mohamed, Mahmut Karakaya, Ahmed Elgebaly, Jamilah Alrahimi, Raed Alkutshan, Adel Tash

Saudi Medical Journal

ABSTRACT Objectives: To validate the diagnostic performance of the iSelfie Heart Health tool compared to standard-of-care devices, focusing on accuracy, reliability, and classification capabilities. Methods: Vital sign measurements from 579 participants were analyzed using the iSelfie tool in calibrated and non-calibrated modes. Further analyses applied the Association for the Advancement of Medical Instrumentation (AAMI) standards and criteria for cuff-based blood pressure (BP) devices. Primary endpoints included mean absolute error (MAE) and cumulative error percentages for all vital parameters. Binary and multi-class classification analyses evaluated the device’s performance to categorize hypertension grades. Results: In calibrated mode, the iSelfie tool demonstrated high …