Digital Commons Network^™

Consensus-Based Expert Recommendations For Diagnosis And Clinical Management Of Vanishing White Matter., Romy J. Van Voorst, Daphne H. Schoenmakers, Joshua L. Bonkowsky, Adeline Vanderver, Ingeborg Krägeloh-Mann, Geneviève Bernard, Enrico Bertini, Ali Fatemi, Paulo V. Sgobbi, Nicole I. Wolf, Samuel Groeschel, Davide Tonduti, Caroline Sevin, Jennifer L. Orthmann-Murphy, Ludger Schöls, Ettore Salsano, Bernard Brais, Nicole Jaffe, Kasper W. Ter Horst, Sabine E. Hannema, Katherine G. Hayes, Jochen Meyburg, Marc Van Heerde, Anne Marie Sbrocchi, Rosalina Van Spaendonk, Isabelle Thiffault, Geesje H. Hofsteenge, Carolina Sudmeier-Broek, Corrie Timmer, Donna Skwirut, Allyson Buck, Bret Hollberg, Ron Chapleau, Hanka Dekker, Susan G. Campbell, Truus E M Abbink, Prisca S. Leferink, Marjo S. Van Der Knaap

Manuscripts, Articles, Book Chapters and Other Papers

Vanishing white matter (VWM) is a rare disorder, characterized by degeneration of CNS white matter, clinically often exacerbated by stressors such as fever and minor head trauma. VWM is caused by biallelic pathogenic variants in the EIF2B1-5 genes, causing reduced activity of eukaryotic initiation of translation factor 2B, resulting in dysregulation of the integrated stress response (ISR). New scientific insights and increased clinical trials in experimental therapies highlight the need for clinical guidelines to improve and standardize care for patients with VWM worldwide. Standardized care is important for therapy development, as it lessens clinical variability of trial participants at study …

The Activity Of Unripe Wood Apple (Limonia Acidissima Groff) Peel And Flesh Extracts In Inhibiting Diarrhe-Causing Bacteria, Idar Idar, Ika Kurnia Sukmawati, Dewi Kurnia, Tina Siti Nurjanah, Lestari Hutasoit

Chimica et Natura Acta

Diarrhea is characterized by having liquid stool more often than usual, typically occurring three or more times within a 24-hour period. While rarely fatal, it can disrupt daily life and is often treated with antibiotics due to pathogens like Bacillus cereus, Shigella flexneri, and Salmonella typhimurium. An overgrowth of Escherichia coli can also be a contributing factor. Recent studies suggest that unripe wood apples may have antibacterial properties. This study evaluates the antibacterial activity of extracts from the peel and flesh of the fruit against the bacteria, as mentioned earlier. Using disk diffusion, microdilution, and bioautography methods, it was found …

In Silico Approach Of Flavonol In Hibiscus Sabdariffa As Proteasome Inhibitors Targeting The Ubiquitin-Proteasome Pathway, Nur Amalia Choironi, Syakhsiyatunnisa Galuh Prameswari, Hanif Nasiatul Baroroh

Chimica et Natura Acta

Multiple myeloma is a blood cancer characterized by the abnormal proliferation of B cells that accumulate in the bone marrow. The proliferation of these cells depends on the role of the proteasome through the ubiquitin-proteasome pathway to degrade proteins that regulate the cell cycle, apoptosis, and stress response. The proteasome is the main target of proteasome inhibitors for the treatment of multiple myeloma. Flavonoid compounds in Hibiscus sabdariffa flowers, such as isoquercitrin, quercitrin, quercetagetin, isorhamnetin, and astragalin, have the potential to act as proteasome inhibitors. The insilico study aims to determine the potential of these compounds as proteasome inhibitors based …

Explainable Machine Learning Using Emg And Accelerometer Sensor Data Quantifies Surgical Skill And Identifies Biomarkers Of Expertise, Rahul Soangra, Areef Hossain, Jay Sonagra, Vennila Krishnan

Physical Therapy Faculty Articles and Research

Traditional evaluations of surgical skill rely heavily on subjective assessments, limiting precision and scalability in modern surgical education. With the emergence of robotic platforms and simulation-based training, there is a pressing need for objective, interpretable, and scalable tools to assess technical proficiency in surgery. This study introduces an explainable machine learning (XAI) framework using surface electromyography (sEMG) and accelerometer data to classify surgeon skill levels and uncover actionable neuromuscular biomarkers of expertise. Twenty-six participants, including novices, residents, and expert urologists, performed standardized robotic tasks (suturing, knot tying, and peg transfers) while sEMG and motion data were recorded from 12 upper-extremity …

Are E-Cigarettes A Safer Alternative? Revisiting The Cardiovascular Cost Of Nicotine Delivery, Jason D. Gardner

School of Graduate Studies Faculty Publications

No abstract provided.

Disrupting Cell Death: Ferroptosis And Pyroptosis Inhibition In Hepatic Ischemia-Reperfusion Injury Via Modulation Of Gpx4 And Cgas Pathways By Deferoxamine And Octreotide,, Rasha A. Tawfiq, Yasmeen Attia, Hameis M. Sleem, Mai Ghoneim Dr.

Pharmacy

Hepatic ischemia-reperfusion injury (HIRI) is a significant complication of liver transplantation, often precipitating postoperative liver dysfunction/failure. Given the rising global prevalence of end-stage liver disease, which necessitates liver transplantation, protecting against HIRI is crucial. Here, we investigated the effects of octreotide (OCT), a pyroptosis inhibitor, and deferoxamine (DEF), a ferroptosis suppressor, individually and combined in the HIRI model. Their impact on cyclic GMP-AMP synthase/stimulator-of-interferon (cGAS/STING) genes and glutathione peroxidase 4 (GPX4) activity was explored. Male rats (n = 4–5) were subjected to 30 min ischemia followed by 3 h reperfusion and treated with OCT (75 μg/kg; 30 μg/kg, i.p. & …

Advancing Louisiana's Cropping Systems: Sustainable Bioenergy Production, Cover Crops, And Technology Integration, Pedro R. Carrillo

LSU Doctoral Dissertations

The adoption of cover crops in Louisiana is lower than the national average, underscoring the need for region-specific research to address environmental challenges and demonstrate the short-term benefits of these practices within existing production systems. This research evaluated the integration of cover crops (CC) in energy cane (Saccharum spp.) and no-till cotton systems, focusing on their effects on soil health, nitrogen (N) management, and biomass production. Soil health indicators (SHIs), including enzymatic activities (β-glucosidase, β-glucosaminidase, and urease), protein N, inorganic N concentrations (nitrate and ammonium), soil organic matter (SOM), and microbial community composition assessed through ester-linked fatty acid …

Dairy And Food Science Student Newsletter, December 9, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

Electrochemical Sensors For In Situ Monitoring Of Reactive Species During Cold Atmospheric Plasma-Based Therapies, Jonathan Thomas, Suneel Kumar, Gagana Karkada, Julia Sutter, Kristina Pattison, Jason Rainone, Dhruv Patel, Shashank Madhavan, Fred Krebs, Francois Berthiaume, Vandana Miller, Katharina Stapelmann

Kimmel Cancer Center Faculty Papers

Cold atmospheric pressure plasma (CAP) is emerging as a clinically relevant therapy for dermatological conditions such as actinic keratosis, warts, and chronic wounds. However, these therapies lack strategies to monitor CAP delivery in situ and to ensure delivery of an effective CAP dose without unwanted toxicity. CAP acts as a therapeutic agent in these biomedical applications primarily (but not solely) through reactive oxygen and nitrogen species (RONS) generated at transiently high local concentrations. Here we demonstrate the use of bio-electrochemical sensors capable of real-time measurements of key CAP RONS: hydrogen peroxide and oxidation-reduction-potential (ORP). In in vitro scratch assays and …

Communities With Diverse Subsistence Needs Require A Variety Of Functional Tree Traits, Minoseheno Rakotovao, Cortni Borgerson, Kerry A. Brown, Joris P. G. M. Cromsigt, Steig E. Johnson, Onja H. Razafindratsima, Ruth Mendum, Onjaniaina O. Andrianjatovo, Harisoa B. Ravaomanalina, Seheno Andriantsaralaza, Sheila M. Holmes

Department of Anthropology Faculty Scholarship and Creative Works

Tree species preference is an understudied yet crucial component of sustainable forest management, as unsustainable harvesting can lead to non-random loss of functional traits. We examine wood resource preference across five regions of Madagascar's biodiverse eastern humid forests. We asked forest users in 19 men's and 19 women's focus groups to list their preferred tree species for common short- (charcoal, firewood) and long-term (house construction, furniture, tools) uses. We then measured functional traits of 260 preferred and common tree species: height, DBH, bark thickness, specific leaf area, wood specific gravity, and seed dispersal syndrome in the surrounding landscape. Using household …

I Can’T Believe It’S Not Social: Investigating The Relationship Between Loneliness, Parasocial Relationships, And Potential Moderators, Hannah I. Suozzi

Master's Theses

Increased loneliness trends coincide with increased media use. Media is turned to as a source of comfort and distraction from the real world. There is cause to believe that people also use media as a way to form parasocial relationships (PSRs), one-sided relationships audiences form with media figures (i.e., celebrities, influencers, and fictional characters). The connection between loneliness and PSR is thought to be moderated by social vulnerability, particularly the need to belong (NTB) and ethnicity. The medium from which PSRs originate lacks empirical study. To address the limitations, this study analyzed data collected from San Jose State University students …

Rural Maternal Health And Information Exchange Challenges In Western New York, Stephanie Lynn Durfee, Sharon Hewner

Biennial Convention (CONV)

Background/Purpose: Our pregnancy healthcare work in Western New York (WNY) has revealed a pressing issue: high-risk patients are often forced to seek care outside their communities, leading to significant delays in addressing their medical and social needs. Our research, focusing on poor pregnancy outcomes in WNY rural areas, underscores the urgency. The challenges of limited resources and distance from healthcare facilities make it difficult for these individuals to receive adequate pregnancy care, resulting in gaps in health information due to fragmented care and disparate health information exchange databases.

Methods: To address this, we used the AHRQ CCSR to manually review …

Factors Influencing Secondary Traumatic Stress In Neonatal Intensive Care Unit Nurses, Heemoon Lim, Hyejung Lee

Biennial Convention (CONV)

Secondary traumatic stress is a significant occupational hazard for healthcare providers, particularly neonatal intensive care unit nurses, who are frequently exposed to traumatic events while caring for newborns and managing the emotional distress of the newborns’ families. This study aimed to assess the prevalence of secondary traumatic stress among neonatal intensive care unit nurses, identify its influencing factors.

This cross-sectional study recruited 131 neonatal intensive care unit nurses from 22 hospitals in South Korea using convenience sampling. Among them, 13 nurses were selected for qualitative interviews through purposive sampling. Data were collected via an e-survey and in-depth interviews from August …

The Patient Violence Framework, Laura Graham, Jennifer Bail

Biennial Convention (CONV)

Patient Violence against nurses is a widespread problem resulting in both emotional and physical injury to the nurse. Emergency Department (ED) nurses are at an increased risk due to the volume and variety of the patients they serve, and the general chaotic environment of the ED; however, little research has been done examining the characteristics of patients who offend and the physical environment of the ED where the event happened. The aim of this three-article dissertation was to develop a more thorough understanding of the personal attributes (endogenous) of the individual patient and external (exogenous) factors of the ED setting …

An Exploratory Evaluation Of The Kalamazoo River Watershed Council: Assessing Organizational Impact And Value, Alexander Mendez

Honors Theses

The Kalamazoo River Watershed Council (KRWC) plays a central role in protecting, restoring, and promoting the long-term health of the Kalamazoo River watershed, a geographically expansive and ecologically complex system facing persistent challenges from legacy contamination, nonpoint source pollution, land-use pressures, and inequitable access to watershed resources. This honors thesis presents an exploratory organizational evaluation of the KRWC, assessing its role and relevance within the watershed, the effectiveness of its programs and partnerships, the strengths and limitations of its governance structure, and opportunities to strengthen its long-term sustainability and impact.

Guided by principles of Practical Participatory Evaluation (PP-E) and Fourth …

In Their Own Voice: A Grounded Theory On Overcoming Internet Gaming Disorder, Jayson Carmona

Theses and Dissertations

Internet Gaming Disorder (IGD) is highly comorbid with depression, anxiety, sleep loss, lower productivity, and social isolation. The DSM-5 TR designates IGD as a condition for further study, however the ICD-11 has designed Gaming Disorder as a codified illness. While most studies look at IGD via a medical model lens focusing almost exclusively on symptomology, very little research explores the process of recovery in IGD. In this grounded theory inquiry, a theory of recovery from IGD is generated. Secondary internet data consisted of 113 posts on the subreddit /r/StopGaming on reddit.com. This resulted in 196 pages of data. Researcher used …

Adolescent Children’S Risk Of Long Covid-19 Syndrome Based On Diet And Demographic Factors From An Online Survey, Christopher Waskewich

Journal of Social, Behavioral, and Health Sciences

Limited information is available on how coronavirus disease 2019 (COVID-19) has [JG1] affected adolescents regarding long-term health risks. This quantitative study focused on the effect of U.S. adolescents’ daily diet, race/ethnicity, levels of income, family level of education, access to health care, age, and comorbidities on the risks of long COVID-19 syndrome. I used the constructs of the health belief model to understand the impact of those variables. The online survey results (N = 298) found that adolescents whose daily vegetable consumption was more than daily recommendations (2–3 cups) had a lower odds ratio of having long COVID-19 syndrome …

Conservative Vs Invasive Interventions For Temporomandibular Disorders–An Executive Summary Of The Clinical Practice Guideline, Gary D. Klasser, Charles S. Greene

School of Dentistry Faculty Publications

This guideline is based on the International Association for Dental, Oral, and Craniofacial Research (IADR) list of keypoints for the diagnosis and management of TMDs. Clinical Question: Are conservative reversible therapies more effective for TMDs as compared to invasive and irreversible interventions?

Predictors Of Sexual Violence Prevalence At U.S. Colleges And Universities, Theodore Daniel Hostikka

Walden Dissertations and Doctoral Studies

This research explored the prevalence of sexual harassment and assault among students at U.S. colleges and universities, aiming to quantify incident rates and assess their impact on academic and psychological well-being. Grounded in socioecological and intersectional theories, the research examined how environmental interactions and interconnected social identities shape individual experiences. Specifically, this research explored (a) the link between the percentage of female students and the prevalence of sexual violence on campuses; (b) how the proportion of first-generation students relates to sexual violence prevalence; (c) the connection between campus size and rates of sexual violence; and (d) whether gender makeup, first-year …

Beyond Static Models - A Framework For Evaluating Dynamic Ml Approaches In Heart Failure Risk Prediction, Mohammad Arif Ul Islam

Theses

Heart failure remains a pressing global health challenge, affecting approximately 64 million people and incurring annual healthcare costs of $108 billion, driven by high readmission rates and delayed interventions. Current risk prediction models predominantly rely on static machine learning approaches, utilizing fixed datasets that fail to adapt to the evolving nature of patient health. This limitation results in outdated risk assessments, hindering timely clinical responses and worsening patient outcomes and resource efficiencies. This research addresses a fundamental methodological gap by developing and validating a chunk-based ensemble framework that enables researchers to evaluate dynamic machine learning potential using readily available static …

515-517 West 171st Street Llc V. Sequin

All Decisions

A landlord initiated a licensee holdover proceeding. The tenant, son of the former rent-controlled tenant, moved for summary judgment on his succession defense, claiming he primarily resided with his deceased father. The court granted the tenant's motion, finding sufficient evidence of co-residency for the statutory period, even considering the father's time in a nursing home before death. The landlord failed to raise material issues of fact, and the petition was dismissed, establishing the tenant's right to succeed to the rent-controlled tenancy.

The Effectiveness Of Telemedicine As A Pivotal Tool In Providing Accessible Medical Care, Peyton Wilt

Honors Theses

Telemedicine has emerged as one of the most transformative innovations in modern healthcare, offering new opportunities to bridge long-standing gaps in access, quality, and continuity of care. Rural and underserved communities in the United States face persistent barriers to healthcare, including provider shortages, geographic isolation, limited access to specialty services, transportation challenges, and socioeconomic disparities. These structural barriers often delay diagnosis, disrupt chronic disease management, and worsen overall health outcomes. Telemedicine provides a mechanism to address many of these obstacles by enabling remote consultations, real-time monitoring, follow-up appointments, and access to specialty providers through digital platforms.

This thesis examines the …

The Need To Incorporate Polysubstance Use In Neuropsychopharmacology Research: Biological Lessons And New Opportunities, Max E. Joffe, Susan M. Ferguson, Nick W. Gilpin, Melissa A. Herman, Lori A. Knackstedt, Patrick A. Randall, Abigail G. Schindler, Mary M. Torregrossa, Jennifer A. Rinker

School of Medicine Faculty Publications

Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence and problematic substance use have been limited to the administration of a single substance; however, there is a growing appreciation that this approach has failed to capture the complexities of humans and has stifled translational efforts. Polysubstance use represents the overwhelmingly common patterns of alcohol and drug use in humans. For example, epidemiological studies generally determine that between 70–95 % of individuals with alcohol use disorder use tobacco daily, and upwards …

Taking From The Most Vulnerable: Legal Implications Of Seizing Federal Benefits From Foster Kids, Lucy Johnston-Walsh

Seton Hall Law Review

No abstract provided.

The Parent Caregiving Experience Of School-Aged Children With Cancer, Sofia Flowers

Biennial Convention (CONV)

In 2023, roughly 9,000 children less than 15 years of age were diagnosed with cancer in the United States. This suggests that approximately 18,000 parents were caring for a child newly diagnosed with cancer. In this informal caregiving role, parents’ roles double as both parent to their child and serving as their healthcare advocate. Studying the parent caregiving perspective can provide valuable insights for the professional health care team to guide their practice. The purpose of this project was to characterize the symptom management and caregiving experiences of parents of school-aged children diagnosed with cancer. The project was a secondary …

Evaluating The Impact Of Educational Materials On Mental Health Using Smartphones, Christine L. Hober

Biennial Convention (CONV)

The purpose of this quality improvement project is to explore the impact of smartphone use on mental health issues and evaluate the effectiveness of educational emails with infographics designed to manage smartphone-related issues.

Specifically, the study aims to determine how different levels of smartphone engagement influence the mental health outcomes of sleep disturbances, anxiety, headaches, depression and overall well-being in adult women.

The background for this study is rooted in existing research that links excessive smartphone use to negative mental health outcomes, such as increased anxiety and depression (Twenge & Campbell, 2018). Despite growing concerns about these impacts, there is …

Conceptions Of Indigenous Child Development: Perspective Of Families And Health Professionals, Francisca Marquez-Doren, Camila Lucchini-Raies, Marcela Gonzalez-Aguero, Angelica Farías-Cancino

Biennial Convention (CONV)

Introduction. The factors that deprive children of their rights are well known, and one of them is their belonging to indigenous peoples. Indigenous children in their early childhood are exposed to greater social inequalities, as they are born and develop in more unfavorable living conditions (Alarcón Muñoz et al., 2021; Pyerín & Weinstein, 2015). The percentage of poverty, deficits in education, social security and work is higher in indigenous early childhood (Pyerín & Weinstein, 2015). In Chile, children belonging to indigenous peoples account for around 14% of the population between 0 and 9 years of age, with the Mapuche, Aymara …

Reducing Moral Distress Through Improved Interprofessional Collaboration In End-Of-Life Care, Marissa Teresa Perino

Biennial Convention (CONV)

Inadequate interdisciplinary collaboration in end-of-life care can result in moral distress among nurses, reflecting conflicts between core nursing values and physician expectations. This quality improvement project seeks to reduce moral distress by enhancing collaboration between physicians and nurses in providing end-of-life care in a defined microsystem on the Transitional Care Unit (TCU). A pre-survey of registered nurses (RNs) revealed that moral distress occurs when caring for actively dying patients, regardless of their code status. Nurses identified a need for improved communication with physicians to facilitate timely implementation of comfort medication order sets and better address the palliative needs of these …

Huddle Up! A Quality Improvement Project To Improve Discharge Length Of Stay, Joshua S. Monsivais

Biennial Convention (CONV)

Prolonged discharge patient encounter length of stay (LOS) in emergency departments (ED) contributes to overcrowding, delayed care, and increased costs. This Quality Improvement (QI) project was initiated at a community, 42-bed Emergency Department that services approximately 75,000 patients annually to address the baseline average discharge LOS of 294 minutes from January 2024 - August 2024. The organizational goal for these discharged patients sits at 165 minutes. The project’s aim was to reduce discharge LOS by implementing structured TeamSTEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety) huddles to enhance communication, optimize patient flow, and improve throughput efficiency.

This …

Reducing The Strain On Emergency Medical Services: A Rural Community Nursing Intervention, Nikoli Yudin, Daniel Evoy, Cameron Kiersch, Robin Haugh

Biennial Convention (CONV)

Introduction: Community nursing serves as an alternative healthcare model aimed to enhance access to care for patients who are Medicare beneficiaries in rural areas and have a chronic medical condition. Timely access to healthcare is essential to prevent frequent emergency department (ED) visits and hospitalization.

Background: Over 80% of Medicare beneficiaries manage at least one chronic illness while 68% manage two or more. Populations in rural areas face significant barriers to healthcare access including provider shortages and geographic isolation. The community nursing intervention reduces ED visits and hospital admissions for Medicare patients with chronic disease in rural settings.

Methods: A …