Digital Commons Network^™

Beyond Precision: Ambiomic Survivorship In Childhood And Aya Cancer., Juan Antonio Ortega-García, Omar Shakeel, Nicole Wood, Antonio Pérez-Martínez, Jose Luís Fuster-Soler, Mark D. Miller

Manuscripts, Articles, Book Chapters and Other Papers

Background: Survival among children and adolescents and young adults (AYA) with cancer has improved substantially over recent decades; however, dominant survivorship models remain reactive-activated post-treatment and anchored to static exposure- and organ-based screening. This design underuses the anticipatory window at diagnosis and overlooks environmental and social determinants that modulate outcomes across the life course. Methods: We narratively reviewed international frameworks including the Children's Oncology Group (COG), the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG), the Pan-European Network for Care of Survivors after Childhood and Adolescent Cancer (PanCare) and the National Comprehensive Cancer Network (NCCN), and synthesized evidence …

The Impact Of New York City’S Bail Reform, Ruya Y. Kutgun

Honors College Theses

This thesis examines the impact of New York City’s bail reform on crime, recidivism, and jail populations, with particular attention to whether the reform has contributed to increased violence. Implemented in 2020 to reduce racial and economic inequalities, bail reform eliminated cash bail for most low-level offenses and emphasized the least restrictive pretrial conditions, with subsequent amendments expanding eligibility for detention. Using cross-sectional data from multiple governmental and research institutions, this study analyzes arrest rates, rearrest rates, and jail population trends before and after implementation. Findings indicate no significant increase in recidivism or violent crime attributable to bail reform. Fluctuations …

Review Of Nutrition: Science And Everyday Application – Second, Sara M. Reyna

Open Educational Resources - Reviews

No abstract provided.

The Effect Of Wearable Resistance Microloading On Sprint Biomechanics, Curtis King

Doctorate in Kinesiology

Wearable resistance refers to the practice of attaching weight to specific body segments during sport-specific movements. This study investigates the impact of progressive microloading training, which involves wearing wearable resistance on the torso (3%, 5%, 10%), on sprint mechanics and performance among competitive athletes. A total of twenty-two participants engaged in a nine-week study that included both progressed and non-progressed group protocols. Sprint times, hip angles, and perceived fatigue were monitored at pre, mid, and post-intervention. A manual biomechanical analysis combined with SPSS-based repeated measures ANOVA indicated no statistically significant changes in hip angle or sprint times between the groups. …

Evaluating The Effects Of Visualization On Vertical Jump Performance In Varsity High School Athletes, David Linton

Doctorate in Kinesiology

This study examined the effects of guided visualization on vertical jump performance in high school varsity athletes. Twenty varsity athletes (ages 13–18) were randomly assigned to either a control group or a visualization group. Following baseline testing, participants completed seven sessions across three weeks. All sessions included a standardized dynamic warm-up. The control group engaged in passive rest prior to testing, while the experimental group completed a five-minute guided visualization exercise. Vertical jump height was measured using a Vertex Vertical Jump Trainer. A randomized controlled pretest–posttest design was employed. Data were analyzed using independent samples t-tests and two-way mixed factorial …

The Sustainability Game: A Case Study Of The Effectiveness Of A Training Game, Michał Mijal

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The purpose of this article is to analyse the possibilities and limitations of using the educational game “Eko Smakosz” in academic teaching, as well as to evaluate the potential of adapting its mechanics for managerial training and scientific research.

Design/methodology/approach: A case study method was employed, comprising quantitative research (pre-test and post-test) and qualitative research (participant observation and DATA model debriefing). The study was conducted on a group of 14 individuals (university students and employees) who played a series of game sessions.

Findings: The study demonstrated an increase in knowledge and participant engagement with subsequent gameplay …

Studia I Materiały Nr 2/2025 (43)

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Entire Volume Studia i Materiały 2/2025 (43)

Micro-Credentials As A Tool To Support Sustainable Development Academic Education – Survey Results, Mariola Zalewska

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The aim of this study is to explore the potential of micro-credentials as a tool for integrating Education for Sustainable Development (ESD) into university curricula and for mitigating student dropout. In light of delays in achieving the 2030 Agenda goals, the study examines whether micro-credentials can enhance sustainability competencies through flexible, student-centred learning pathways. To address the research gap regarding the limited understanding of student perceptions of both ESD and micro-credentials, a pilot study was conducted among students at the Faculty of Management, University of Warsaw.

Design/ methodology/approach: The survey covered the following thematic areas: perceived importance of …

Acceptability Of Using Brain-Computer Interface In The Workplace – Attitudes Of Prospective Employees, Aneta Biernikowicz

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: This study aims to examine the attitudes of young management students toward the use of brain–computer interfaces (BCIs) in the workplace, considering both the potential benefits and the associated risks of this technology.

Methodology: The study is exploratory in nature and was conducted using the CAWI method on a group of management students. Both open-ended and closed-ended questions were used on a 7-point Likert scale. Qualitative analysis included descriptive and focused coding, and quantitative analysis - descriptive statistics.

Results: Respondents showed a high level of awareness of the existence of BCI technology, mainly for medical purposes. …

Strength And Conditioning As An Injury Prevention Strategy In College Baseball, Elizabeth Record

Doctorate in Kinesiology

Shoulder injuries are common and often result in impairments, particularly among baseball players. The clinical management of shoulder injuries is of interest to a wide-ranging audience within the sports medicine community. This dissertation aimed to investigate the effects of a strength and conditioning program on injury prevention in college-aged baseball players, hypothesizing that a comprehensive strength and conditioning program implemented before the start of the season would prevent shoulder injuries in baseball players over the course of one spring season at the collegiate level of baseball. Four participants completed a four-week strength and conditioning program before the start of their …

The Effects Of Kyphosis Angle Reduction On Balance, Fall Risk, And Quality Of Life, Karen Buckley

Doctorate in Kinesiology

Purpose: Hyperkyphosis is an abnormal sagittal plane curvature of the spine. The kyphosis angle (KA) increases as age increases, leading to fractures, falls, and potential mortality. This study aims to determine if reducing the KA improves balance, stability, and quality of life in the elderly. Methods: Thirty-one participants, including males and females, aged 63.03±9.61, participated in this study. This study used the kyphosis index (KI), which is a measurement of the distance between the occiput and the wall. Elderly individuals with an occiput wall distance (OWD) of > 4cm participated in this study. The Ferrans and Powers Quality of Life questionnaire, …

Ai And Naval Operations, Wolff Heintschel Von Heinegg

International Law Studies

Artificial intelligence systems in naval operations are reality. They enhance naval capabilities in various respects. Autonomous surface and underwater vehicles depend on such systems. Moreover, these systems contribute to threat detection and identification, to real-time strategy optimization, and to intelligence analysis. The present article provides a brief analysis of the legality of AI systems used by naval forces under the law of naval warfare, which, in many respects, differs considerably from the law of land warfare. Accordingly, it is necessary to distinguish between attacks from the sea against targets on land and attacks against targets at sea and in the …

Development Of Self-Assembled Polymeric Polyplexes For Microrna Delivery: Toward Treatment Of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

Theses & Dissertations

Self-assembled polymeric polyplexes have the potential to serve as an RNA interference (RNAi) delivery platform for the combined inhibition of CXCR4 and miR-155 in the treatment of alcohol-associated liver disease (AALD). A central challenge in RNA delivery is balancing the extracellular stability of polyplexes, cellular uptake, and intracellular release of RNA cargo. We developed polymeric polyplexes using the CXCR4-antagonist polymer PAMD, designed to target CXCR4 on activated hepatic stellate cells (HSCs) and deliver therapeutic miRNA to activated Kupffer cells (KCs) in fibrotic liver. We improved the polyplexes by cholesterol modification of PAMD and by PEGylation of PAMD-Ch. The cholesterol modification …

Mechanistic Insight Of Neuropilin-2 Expression During The Progression Of Prostate Cancer, Sanika Bodas

Theses & Dissertations

Advanced prostate cancer represents a particularly aggressive and challenging form of prostate cancer (PCa) that shows resistance to both traditional therapies, such as androgen deprivation therapy, and newer treatment modalities like hormone therapies and immunotherapies. For patients diagnosed with advanced stages of PCa, treatment options are limited, and chemotherapy is often the last line of defense. Unfortunately, chemotherapy can severely diminish the quality of life, particularly in older patients, due to its harsh side effects, including fatigue, immune suppression, and overall physical decline. Despite these challenges, researchers and clinicians remain focused on developing more effective and targeted treatments for patients …

Posterior Anatomic Limit For Mandibular Molar Distalization In Subjects With Different Growth Patterns, Genders, And Growth Status, Rehana Bashir

Theses & Dissertations

The objective of this study is to identify the anatomical limits for mandibular molar distalization, a technique frequently employed in orthodontics to address various malocclusions. Mandibular molar distalization plays a critical role in the management of crowding, and correction of the molar relationship.

It is imperative to assess the posterior anatomical space (PAS) in the mandibular retromolar area prior to distalization or uprighting the mandibular molars to avoid periodontal issues (dehiscence, orthodontically induced root resorption, and tooth mobility) and achieve successful treatment outcomes.

A clinical question that, however, isn't well understood is whether the amount of mandibular molar distalization is …

A Comparison Of Tenecteplase To Alteplase For Treatment Of Acute Ischemic Stroke Using Epic Cosmos Database, Marco Gonzalez Castellon

Theses & Dissertations

Ischemic stroke is highly prevalent and an important cause of morbidity, mortality, and long-term disability in the in the United States. The incidence and prevalence of stroke is expected to increase in the next few years due to several factors including aging of the U. S. population, improved treatment, and socioeconomic factors. In 1996, the FDA approved rtPA for the treatment of ischemic stroke patients. Patients had a greater likelihood of recovering successfully. However, rtPA has significant limitations, such as an elevated risk of intracranial hemorrhage, administration difficulties, and limited effectiveness. In March 2025, the FDA approved the use of …

Evaluating Bmx-001 As A Selective Radioprotector For Healthy Tissue In Pelvic Cancers, Molly Myers

Theses & Dissertations

Pelvic cancers, including rectal, anal, and prostate cancer, are relatively survivable cancers with high five-year survival rates, partially due to the addition of radiation to treatment regimens. Radiation confers excellent tumor control, but also causes damage to surrounding tissue, resulting in both short-term and long-term side effects. In a patient population that is surviving longer after treatment, limiting the impact of side effects is instrumental to improving patient quality of life. Radiation-induced ROS is instrumental in causing these side effects and provides a unique opportunity to protect healthy tissue from damage while sensitizing cancer tissue to treatment, as cancer cells …

Development And Characterization Of Non-Viral Delivery Systems For Pulmonary Delivery Of Nucleic Acid Therapeutics, Kasturi Siddhanta

Theses & Dissertations

The development of non-viral delivery systems for pulmonary delivery of nucleic acid therapeutics is driven by the need for safer and more accessible approaches to treat lung diseases, while avoiding the systemic side effects and immune responses associated with viral vectors. Such systems encompass both non-invasive inhalation-based platforms, and systemically administered platforms designed to achieve localized lung delivery. These strategies aim to enable high drug concentrations at the site of action, rapid onset of therapeutic effect, and greater therapeutic efficacy than existing treatments. Designing effective pulmonary delivery systems requires precise optimization of particle properties—including size, morphology, surface characteristics, cell-specific targeting, …

Role Of Nadph Oxidase 4 In Murine Cancer-Associated Fibroblast, Faith M. Gomez

Theses & Dissertations

Breast cancer is the second leading cause of cancer deaths in women in the United States. Frontline hormone therapies for breast cancer prove ineffective in triple negative breast cancer tumors wherein the hormones estrogen, progesterone, and HER2 are downregulated or absent; therefore, patients diagnosed with triple negative breast cancer are primarily limited to chemotherapies which carry a higher failure and resistance rate. Here we target cancer associated fibroblasts as potential drivers of chemoresistance in triple negative breast cancer. We investigated the mechanism by which Nox4 regulates the YAP/TAZ pathway in modulating DTX sensitivity and sought to determine if targeting Nox4 …

Comparison Of Cervical Spine Injury Clinical Prediction Rules For Children After Blunt Trauma, Lois K. Lee, Fahd A. Ahmad, Lorin R. Brown, Monica Harding, Lawrence Cook, Kathleen Adelgais, Rebecca K. Burger, Alexander Rogers, Leah Tzimenatos, Lauren C. Riney, Daniel Rubalcava, Caleb E. Ward, Kenneth Yen, Julie C. Leonard

2020-Current year OA Pubs

No abstract provided.

Limiting A Liberal Education: Exploring Technology Access And Equity Through Universal Design And Critical Disability Studies, Marisa R. Carlson

Electronic Theses and Dissertations

This quantitative improvement study investigates how classroom technology policies impact equity, access, and alignment with liberal arts values at a small Catholic liberal arts college. The study arose from concerns regarding academic accommodations, where students needed to formally request access to digital tools that were widely available. The focus is on inconsistent and sometimes restrictive technology policies that create barriers for students relying on these resources.

Interpreted through the conceptual frameworks of Universal Design for Learning (UDL) and Critical Disability Studies (CDS), this study was guided by the following research questions:

1. What expectations do students have regarding access to technology …

Physiological Demands Of Virtual Reality Exercise Games: An Analysis Of Energy Expenditure And Exercise Intensity, Neil Panchal

Doctorate in Kinesiology

Virtual reality (VR) technology offers potential as an exercise modality, yet comprehensive physiological assessments using gold-standard methodology remain limited. This study investigated the physiological demands of three VR fitness games, Beat Saber, Punch Fit, and RUN, by examining exercise intensity, energy expenditure, and time spent above American College of Sports Medicine (ACSM) intensity thresholds. Thirty-two college students (ages 18-32, M = 23.9 ± 3.1 years) completed maximal exercise testing to establish VO₂max, followed by a VR gaming session. Physiological responses were measured using portable indirect calorimetry and heart rate monitoring. Repeated-measures ANOVAs revealed significant differences between games, with large effect …

Leveraging Transcranial Ultrasound Stimulation To Enhance Self-Regulation In Emotion And Sleep, Suraya Dunsford, Mica Komarnyckyj, Elsa Fouragnan

School of Psychology

This Perspective article discusses the emerging potential of transcranial ultrasound stimulation (TUS) as a non-invasive neuromodulatory technique for enhancing self-regulatory processes, particularly emotion and sleep regulation, in healthy individuals. Offering high spatial precision and the ability to target both cortical and deep brain regions, TUS uses focused ultrasound waves to induce acute and delayed effects on brain activity. We propose that combining TUS with neurofeedback methods and/or specific cognitive training exercises may capitalise on these neuroplastic effects, thereby augmenting and prolonging their impact to support lasting improvements in self-regulation. We focus on the domains of sleep and emotion regulation, where …

Associations Of Ccr5Δ32 With Covid-19 In An Iraqi Kurdish Population And Global Allele Frequencies Of Ccr5Δ32, Sherko Subhan Niranji

Human Biology Open Access Pre-Prints

Chemokine receptor 5 Delta 32 (CCR5Δ32), a 32-nucleotide deletion in the receptor’s gene, is associated with infectious diseases (e.g., protection against HIV-1). Studies have yielded conflicting results regarding this receptor and Coronavirus Disease 19 (COVID-19) in various nations. No studies have investigated the CCR5 genetic polymorphisms in Kurdish populations. Few studies have been performed in Iraq regarding associations of CCR5 with infectious diseases including COVID-19. This study aims to investigate associations of CCR5Δ32 with COVID-19 in an Iraqi Kurdish population and global allele frequencies of the CCR5Δ32 associated with various diseases around the world.

Conventional polymerase chain reaction (PCR) was …

Powering Up Clinical Scholarship In Dental Journal Club: Article Review Session 1, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation is designed for Dental Services Journal Club attendees as Session 1 of an article‑based workshop series on clinical scholarship, using three exemplar papers on drug‑induced gingival overgrowth (Mavrogiannis 2006, Fardal 2015, Mawardi 2021) to illustrate how to read, interpret, and critically appraise different study designs (narrative review, retrospective cohort, systematic review). The session emphasizes understanding methods and limitations (e.g., non‑systematic literature searching, confounding and missing data, lack of baseline matching, single‑center bias, heterogeneous treatments), interpreting risk of bias and evidence levels, and applying structured critical appraisal language so that dental clinicians can more confidently evaluate periodontal and pharmacologic …

Not Always Welcomed, Lavaughn Wesley

Electronic Theses and Dissertations

Abstract

This qualitative dissertation explores the systemic barriers faced by adjudicated and long-term suspended youth during their reentry into the public school system, focusing on a local urban community in Pennsylvania. Through the lens of Institutional Complexity Theory, this study examines how interagency disconnection, implicit bias, inequitable disciplinary practices, and inadequate support structures contribute to the marginalization of historically underserved students, particularly Black youth, students with disabilities, and those from low-income households.

The research is driven by two central questions:

(1) What are the barriers for adjudicated youth during the reentry process?

(2) How can the home school reentry process …

Three Case Studies Of Transformative Learning In A Service-Learning Anthropology Course, Elizabeth S. Schulte

Theses and Dissertations

This study investigates the processes of personal transformation of three students enrolled in a service-learning based course that I taught at Brigham Young University. Informed by my observations as instructor of the course, in the analysis below I draw upon these students' weekly personal reflection essays to describe the process of individual transformation of these three students across the semester. This accounting provides insight into aspects of and contributing factors to that growth. I propose that a service-learning based course design with a framework of anthropological theory is a good way to facilitate transformational educational experiences. Aspects of service-learning such …

Understanding Asynchronous Learning For Moana Communities By Moana Educators In The Digital Vā, Theresa Pamela Onesemo-Holmes

Theses and Dissertations

The COVID-19 pandemic caused a dramatic shift from face-to-face learning to an online learning modality for learners globally. Moana (Pacific) communities of all ages were affected by the change due to the existing digital divide that remains an issue today. Research on culturally responsive learning pedagogy for Moana communities prior to the pandemic focused on in-person experiences. Navigating the vā (the relational space between all things) to engage with Moana communities was difficult for teachers during pandemic lockdowns. Online learning in Moana communities is an emerging field of research and has typically focused on synchronous learning. Instead, in my research …

Protocol For Nucleo-Cytoplasmic Fractionation Of Mammalian Cells To Study Protein Translocation Via Immunoblotting, Adhikarimayum Lakhikumar Sharma, Eddy Zhu, Rithika Padyala, Kavya Parikh, Mudit Tyagi

Center for Translational Medicine Faculty Papers

Studying protein translocation is essential for understanding protein function and regulatory mechanisms, including the activity of transcription factors. Here, we present a protocol for isolating high-quality cytoplasmic and nuclear protein fractions from mammalian cells. We describe steps for separating cytoplasmic proteins, washing nuclei, and extracting nuclear proteins. We then detail procedures for quantifying proteins and analyzing their distribution by immunoblotting within a single immunoblot. This protocol is applicable to both suspension and adherent cell types. For complete details on the use and execution of this protocol, please refer to Sharma et al.

‘If You Can Dream It, You Can Do It:’ Bridging Creative Ideas & Beliefs In A Neurodiverse Workforce Through Autonomy & Social Support, Mesaley A. Alemseged

Industrial-Organizational Psychology Dissertations

Reports from the business world highlight the competitive advantage that neurodiversity can provide for workplace creativity and innovation through the inclusion of workers who represent a broad range of perspectives and abilities. However, while neurodivergent individuals have naturally divergent ways of thinking, producing creative works might not come as easily in workplaces designed for neurotypical forms of thinking and working. Drawing from the componential theory of creativity, this study sought to explore how neurodivergence, as it relates to creativity-relevant processes, and work characteristics related to the social environment can influence creativity across the various stages of the creative process. While …