Digital Commons Network^™

Learning From Images And Text (Clinical) Data: Toward Putting Ai In Radiology Workflows, Pan Xiao

McKelvey School of Engineering Graduate Student Theses & Dissertations

The rapid growth of medical imaging data highlights the need for intelligent systems that can understand both radiological language and image content. This dissertation presents two complementary research directions that advance machine learning in radiology through large-scale natural language understanding and unsupervised image representation learning. The first part develops and benchmarks machine learning models for identifying follow-up recommendations in radiology reports—a task essential for improving patient care and reducing missed follow-ups. Using 49,769 reports across multiple modalities and three institutional datasets, along with external and temporal test sets, thirty-two classification methods were systematically evaluated on both findings and impression sections. …

Transforming Co2 Into Value-Added Products: Liquefied Petroleum Gas And Solid Carbon Materials, Kaiying Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

The escalating climate crisis, driven by anthropogenic carbon dioxide (CO2) emissions, necessitates the development of advanced Carbon Capture and Utilization (CCU) technologies. A critical distinction within CCU lies between transient carbon cycling, which converts CO2 into fuels, and permanent sequestration, which transforms it into durable, solid materials. This dissertation addresses fundamental catalytic challenges across both pathways to develop economically viable and technologically sound solutions for CO2 valorization. This work seeks to answer two primary research questions: (1) How can the catalyst temperature mismatch and stability limitations in the tandem conversion of CO2 to Liquefied Petroleum Gas (LPG) be overcome to …

P-15 Peptide Enhanced Bone Graft Improves Time To Fusion In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study, James S. Harrop, Michael P. Steinmetz, John E. O'Toole, Christopher D Chaput, Rick C. Sasso, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold

Department of Neurosurgery Faculty Papers

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, and controlled pivotal study.

OBJECTIVE: Compare time-to-fusion in patients treated with P-15L (PearlMatrix TM P-15 peptide enhanced bone graft) versus local autograft over 24 months and evaluate changes in pain and quality of life at 24 months relative to baseline.

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated breakthrough device, is a composite bone graft with P-15, a 15-amino acid polypeptide that promotes cellular adhesion, proliferation, and differentiation to support bone formation.

METHODS: Patients (22-80 y) with degenerative disc disease were randomized to the investigational (P-15L) or control (local autograft) group during single-level transforaminal lumbar …

A Fish & A Bird, Deanna Moorehead

Theses

As a curtain of trees opens and dawn breaks over the glistening waters of Lake Ontario, a fish and a bird spot each other through the surface and fall madly in love. They dance and sing together from their respective atmospheres, yet each time the bird soars past the water's edge and onto the beach, the fish cannot follow. Night after night, by the light of the moon, the fish trains herself to leap out of the water, hoping to breach high enough to join her beau above. Late one afternoon, the fish approaches the shore, where the bird stands …

Metabolomic Profiling Reveals Brain Lipid Alterations In Pex7-Deficient Models Of Rhizomelic Chondrodysplasia Punctata, Riya Sankhe, Meredith I Williams, Wedad Fallatah, Laura Mackay, Mary Layne Brown, Pranjali Bhagwat, Sarah H Elsea, Nancy Braverman, Michael F Wangler

Duncan NRI Faculty and Staff Publications

Rhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisomal disorder characterized by skeletal shortening, intellectual disability, seizures, cataracts, and reduced lifespans. RCDP1 is caused by biallelic loss-of-function variants in PEX7, which encodes a protein required for importing select enzymes into the peroxisome matrix, including those essential for ether lipid synthesis (e.g., plasmalogens) and the branched-chain fatty acid catabolism. Plasmalogen deficiency is a hallmark of RCDP1 and other peroxisomal disorders, including RCDP types 2-5 (RCDP2-5) and Zellweger spectrum disorders (ZSD). Here, we performed comprehensive metabolomic profiling of clinical samples from RCDP patients and Pex7-deficient mouse models. We identified profound …

Single-Nucleus Multiomics Reveals The Disrupted Regulatory Programs In Three Brain Regions Of Sporadic Early-Onset Alzheimer’S Disease, Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E Sepulveda, Astrid M Manuel, Damian Gorski, Brisa S Fernandes, Meifang Yu, Paul E Schulz, Lukas M Simon, Claudio Soto, Zhongming Zhao

Faculty, Staff and Student Publications

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type–specific transcriptomic changes and linked candidate cis-regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells …

An Integrated Multivariate Econometric Modeling Framework For Risky Driving Behavior Related Crashes: Evaluating Crash Risk And Severity Across Zones, Pabitra Kumar Roy

Dissertations and Theses

Rapid advancements in crash modeling have yet to fully integrate multiple behavior-driven crash types and their severity outcomes within a single, scalable framework, specially in a way that captures the sequential nature of these behaviors where one risky action may amplify another. This study proposed an integrated multivariate econometric framework to jointly model crash frequency and severity outcomes for three major behaviorally driven crash types: alcohol-related, distraction-related, and aggressive-driving-related crashes. Specifically, using Oregon's 2022 census block group-level crash data, we propose an Integrated Multivariate Negative Binomial – Generalized Ordered Probit Fractional Split (IMNB–GOPFS) model to analyze these dimensions simultaneously while …

Daily Intake Of A Lycopene-Rich Juice Is Associated With Reductions In Inflammatory Markers But Not Increases In Skin Carotenoids In A Pilot Study Among Participants With Obesity, Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Elizabeth Gates, Megumi H Seese, Katelyn E Senkus, Santiago Carrero Longlax, Alexandra Portillo-Varela, Andrew R Dinardo, Nancy E Moran

Faculty, Staff and Students Publications

Background

Obesity is associated with systemic inflammation, increasing chronic disease risk. Carotenoids possess anti-inflammatory properties, yet the short-term impact of carotenoid-rich juice intake on inflammation in individuals with obesity remains unclear. Therefore, the purpose of this paper was to examine: (1) participant adherence to a 3-week lycopene-rich juice intervention; (2) variance and effect sizes of responses to the dietary intervention; (3) changes in skin and plasma carotenoids, and inflammatory markers among adults with obesity.

Methods

Twenty-five participants with body mass index (BMI) > 30 kg/m2 were recruited and completed the study. Participants drank 4 ounces (118.3 mL) of study-provided tomato juice, …

Adaptive Neuromodulation Dialogues: Navigating Current Challenges And Emerging Innovations In Neuromodulation System Development, Frederik Lampert, Matthew R Baker, Michael A Jensen, Amir H Ayyoubi, Christian Bentler, Jessica L Bowersock, Rosana Esteller, Jeffrey A Herron, Graham W Johnson, Daryl R Kipke, Christopher K Kovach, Vaclav Kremen, Filip Mivalt, Joseph S Neimat, Theoden I Netoff, Enrico Opri, Alexander Rockhill, Joshua M Rosenow, Kristin K Sellers, Nathan P Staff, Chandra Prakash Swamy, Ashwin Viswanathan, Gerwin Schalk, Timothy Denison, Dora Hermes, Nuri F Ince, Peter Brunner, Gregory A Worrell, Kai J Miller

Faculty, Staff and Students Publications

Adaptive neuromodulation systems and implantable brain-computer interfaces have made notable strides in recent years, translating experimental prototypes into clinical applications and garnering substantial attention from the public. This surge in interest is accompanied by increased scrutiny related to the safety, efficacy, and ethical implications of these systems, all of which must be directly addressed as we introduce new neurotechnologies. In response, we have synthesized the insights resulting from discussions between groups of experts in the field and summarized them into five key domains essential to therapeutic device development: (1) analyzing current landscape of neuromodulation devices and translational platforms (2) identifying …

Socrates And Early Buddhist Medical Ethics: Foundations Of Moral Reasoning In The Care Of Body And Mind, Chandima Gangodawila

Budhi: A Journal of Ideas and Culture

While Buddhist traditions articulate a parallel moral vision in the early discourses of the Pāli Canon, Western traditions usually locate the roots of ethical reasoning in Socratic inquiry. Especially in their approaches to bodily care, spiritual well - being, and moral responsibility, this article contends that both Socratic and Early Buddhist ideas converge on fundamental principles in medical ethics. Through a comparative textual and philosophical study, the paper examines how Socratic dialectics and the Buddha's diagnostic approach to dissatisfa ction/ suffering (dukkha) both produce frameworks for ethical healthcare anchored in the development of virtue, wisdom, and care for the integrity …

Central Bank Crisis Interventions: A Review Of The Recent Literature On Potential Costs, Patrick Aldridge, David A. Cimon, Rishi Vala

Journal of Financial Crises

Central banks may engage in large-scale lending and asset purchases to stabilize financial markets and implement monetary policy during crises. The ability of these actions to restore financial market functioning is well documented; however, they come with costs. We provide a literature review of the costs associated with these post-Global Financial Crisis central bank actions, without commenting on the net benefits they provide. We find support for the premise that crisis actions may negatively impact market liquidity, distort asset prices, increase rent-seeking and inefficient uses of the liquidity provided by the central bank, create international spillovers, and create distortions in …

Extending The Emotional And Multiple Intelligence Theories: Integrating Cultural And Spiritual Intelligence Constructs To Fill Research Gaps, Kimberly J. Mcdonald

The Scholarship Without Borders Journal

This proposed mixed-methods convergent research study aims to explore extending the Emotional Intelligence (EI) and Multiple Intelligences Theories by integrating Spiritual Intelligence (SI) and Cultural Intelligence (CQ) constructs. The goal is to explore the interconnectedness of these intelligences to bridge existing research gaps concerning leadership, EI, SI, and CQ. By employing both quantitative and qualitative data collection methods from organizational leaders, this study seeks to develop a more comprehensive and holistic understanding of leadership efficacy across various organizational contexts. The anticipated outcomes aim to contribute to the body of knowledge and potentially impact leadership development in business, education, and other …

Equity And Effectiveness In Advanced Mathematics Education: A Literature Review Of Ap Calculus, Cambridge Aice, And Ib Curricula, Jinhee Lee

The Scholarship Without Borders Journal

This literature review investigates equity and effectiveness of three globally recognized advanced high school mathematics programs: AP Calculus, Cambridge International Advanced International Certification of Education (AICE) Advanced Level (A-Level) Mathematics, and International Baccalaureate (IB) Mathematics High Level. Access to advanced mathematics is unequally distributed, impacting underprivileged students (Bressoud, 2021). This review examines curriculum content, teaching methods, and assessment strategies in alignment with college admissions, depth of conceptual understanding, inclusion of diverse approaches, and assessment accessibility. Findings will contribute to informed curriculum choices for students and inform equitable practices for educators.

Our Land: Rodger Mcafee And His Life-Long Quest For Community In America, Morgan E. Bowen

Communal Societies

No abstract provided.

Review Of The Utopian Prince: Robert Owen And The Search For The Millennium, Jayne Kamau

Communal Societies

No abstract provided.

The Communal System Of The Amana Colonies: Impact Of Hired Labor, 1884-1932, Angela Tjaden

Communal Societies

No abstract provided.

Zoar In The Civil War: Choosing Between Pacifism And Participation, Philip E. Webber

Communal Societies

No abstract provided.

The Communal Wanderings Of August Jacobi, Peter Hoehnle

Communal Societies

No abstract provided.

From Developmental Communalism To Transformative Utopianism: An Imagined Conversation With Donald Pitzer, Joshua Lockyer

Communal Societies

No abstract provided.

Burden Of Light: The Emissary Of Divine Light Myth System As A Unifying Community Force, Sandy Brown Jensen

Communal Societies

No abstract provided.

The Jasper Colony: A German Utopia On The Iowa Prairie, Peter Hoehnle

Communal Societies

No abstract provided.

A Matter Of Definition: Just What Is An Intentional Community?, Timothy Miller

Communal Societies

No abstract provided.

Full Issue: Volume 4, Issue 1, Edwin Mayorga

#CritEdPol: Journal of Critical Education Policy Studies at Swarthmore College

The fourth issue of #CritEdPol, Journal of Critical Education Policy Studies at Swarthmore College.

Anticolonial Study: Anton De Kom And We Slaves Of Suriname, Jonneke Koomen

#CritEdPol: Journal of Critical Education Policy Studies at Swarthmore College

In 1933 Anton de Kom set up an advice bureau in his family’s yard in Paramaribo, the capital of Suriname, then a Dutch colony. After years of living in The Netherlands, De Kom wanted to hear the klachten (complaints) of Surinamese workers and the unemployed. Thousands responded to De Kom’s invitation; the descendants of African slaves and Asian indentured workers, Indigenous peoples, and Maroon leaders traveled from the South American plantations and forests to share their experiences of exploitation and abuse. After a month, police arrived to shut down De Kom’s listening project, hundreds of Javanese workers squatted in his …

Understanding Alternative Modes Of Study In The 2018 K12 Education Strikes, Erin Dyke

#CritEdPol: Journal of Critical Education Policy Studies at Swarthmore College

In this article, I draw on Eli Meyerhoff’s (2019) Beyond Education: Radical Studying for Another World to suggest that the 2018 “red state” K12 education strikes created spaces, if momentary and often fraught, for many education workers to engage or expand alternative modes of study, modes that have long constituted predominantly women- and rank-and-file-led educator labor organizing. First, I elaborate Eli Meyerhoff’s theorization of modes of study as world-making in the context of education labor organizing and unions. Specifically, I engage his important critique of education as a particular, romanticized mode of study that contributes to liberal capitalist world-making. …

Using Electronic Medical Records To Estimate The Prevalence Of Pediatric Obesity In Mississippi, Brian D. Christman, Abigail Gamble, Sonia Jain, Kalon Kl Ho, Lei Zhang, William B. Hillegass

Journal of Public Health in the Deep South

Background: Pediatric obesity is a major public health concern in Mississippi. However, existing surveillance systems, including the Youth Risk Behavioral Surveillance System, National Survey of Children's Health, and Child and Youth Prevalence of Obesity Survey, are limited by self-reported data, restricted age ranges, and incomplete subgroup coverage.

Purpose: This study evaluates the plausibility of using electronic medical records to improve population-level surveillance of pediatric obesity in Mississippi while addressing issues of data completeness, bias, and representativeness.

Methods: Electronic medical records from 40,215 patients aged 2–19 years who received care at the University of Mississippi Medical Center (2013–2022) were analyzed via …

A Clash Of Conflicting Priorities: Why Did The Battle For The Beveland Causeway Last Almost Three Weeks? 7 October - 24 October 1944, Robert W. Catsburg

Canadian Military History

This article examines the 2nd Canadian Division’s nearly three-week campaign to drive German forces from the Beveland Causeway, a key part of the Battle of the Scheldt. Despite having superior numbers, the Canadians—led by Brigadier Holley Keefler—were unable to break through the enemy lines at Woensdrecht. In the secondary literature, high praise is given to the skill of the German battle group, at the expense of Canadian combat effectiveness. Drawing on primary sources, this article highlights the aggravating factors that contributed to this unexpected stalemate. It shows that, independent of the courage and ability of the soldiers on the ground, …

The Clear-Up: The Anglo-American Experience In Southeastern Italy, 1943–1946, Amy Muschamp

Canadian Military History

As Allied forces gradually ascended Italy in the arduous Italian Campaign, the newly liberated country was left in chaos. Focusing on the often-overlooked experiences of Southeastern Italy, and in particular the area known today as the region of Molise, this article presents an analysis of the Allied clear-up operation within this tumultuous situation. The mass movement of people southwards has been described as the “real drama” of the war for those living in Molise and the experiences of the people here are representative of many in the rural south. Moreover, knowledge gained by Allied forces here would impact future operations …

Lieutenant-Colonel Donald Mackenzie And The 48th Highlanders Of Canada: A Study In Battalion Command And Officer Progression, Tyler Wentzell

Canadian Military History

Lieutenant-Colonel Donald Mackenzie was the commanding officer of the 48th Highlanders of Canada from June 1944 until his death in April 1945. He had been a lieutenant in the militia when the war broke out. His chain of command quickly made him a company commander, then sent him away from the unit to gain valuable staff training and experience. Although lacking combat leadership experience, he rejoined the 48th Highlanders in Italy, became the battalion’s second-in-command, and, after only five months, took over as the commanding officer at the age of twenty-nine. Mackenzie’s experience provides valuable insight into the challenges faced …

Factors Associated With Covid-19 Testing In Structurally Vulnerable Populations: An Exploratory Study In Southern Maine, Grace L Price, Kathleen M. Fairfield, Sumayo Awale, Renee Fay-Leblanc, Caroline Fernandes, Ann Marie R. Hess, Elizabeth A. Jacobs, Donna Lawlor, David Ngandu, Leslie Nicoll, Kinna Thakarar, Ellyn Touchette, Andrew Volkers, Gloria D. Sclar

Journal of Maine Medical Center

Introduction: The COVID-19 pandemic disproportionately affected structurally vulnerable populations in the United States. COVID-19 testing was instrumental in controlling viral spread and linking people to treatment; however, testing rates were lower among racial and ethnic minority groups. Our objective was to identify factors associated with desired COVID-19 testing behavior among vulnerable populations.

Methods: We conducted an exploratory cohort study of at-home COVID-19 testing between March 2022 and November 2023 in Portland, Maine. Partnering with trusted community organizations, we engaged participants from immigrant, housing-unstable, substance-using, and low-income/uninsured communities. Participants received 5 at-home COVID-19 tests every 8 weeks for 48 weeks. Participants …