Digital Commons Network^™

Designing And Implementing Solution-Oriented Team Science Initiatives-A Chronic Pain Example, Nele A Haelterman, Armen N Akopian, Kyle D Allen, Yenisel Cruz-Almeida, Christopher R Donnelly, Brendan Lee, Rebecca Lenzi, Anne-Marie Malfait, Marie Mancini, Maryann E Martone, Joost B Wagenaar, Kim C Worley

Faculty, Staff and Students Publications

Large, collaborative projects that combine researchers from multiple scientific disciplines have become an integral part of the scientific endeavor. While transdisciplinary team science projects hold great potential, they also come with a unique set of challenges compared to monodisciplinary projects. The Science of Team Science (SciTS) field has developed multiple conceptual models and frameworks that guide the design, implementation, and evaluation of team science initiatives to maximize their potential for making breakthrough discoveries and creating solutions for complex problems. While these conceptual models contain a trove of valuable information for successful team science, guidance on how to effectively implement them …

Nanoparticle Contrast Agents For Photon-Counting Computed Tomography: Recent Developments And Future Opportunities, Laxman Devkota, Rohan Bhavane, Cristian T Badea, Eric A Tanifum, Ananth V Annapragada, Ketan B Ghaghada

Faculty, Staff and Students Publications

The clinical availability of photon-counting computed tomography (PCCT) has ushered in a new era of CT imaging. Spectral imaging coupled with superior contrast resolution, and ultrahigh spatial resolution (200 μm) offered by PCCT has the potential to revolutionize value-driven imaging. The potential of multicolor PCCT has generated excitement, and renewed interest, in novel contrast agent development for comprehensive disease interrogation, prediction and monitoring of treatment outcomes. Nanoparticles provide a versatile and powerful platform for the development of next generation contrast agents for spectral PCCT. In this article, we review recent developments and use of nanoparticle contrast agents for PCCT. We …

Mutations In Retinal Cyclic Nucleotide-Gated Channels Identified In Familial Cases Of Inherited Retinal Dystrophies From Pakistan, Zainab Akhtar, Kiran Afshan, Yumei Li, Sumaira Altaf, Aleesha Asghar, Ume Sughra, Wajid Ali Khan, Haiba Kaul, Rui Chen, Sabika Firasat

Faculty, Staff and Students Publications

Purpose: Cyclic nucleotide-gated (CNG) channels are ligand-gated ion channels that transduce light signals into electrical signals in the retinal photoreceptors. Pathogenic variants in CNG channel genes are reported to cause inherited retinal dystrophies (IRDs). The current study used targeted panel sequencing to describe the mutational spectrum of CNG channel genes in familial cases of IRDs from eight consanguineous Pakistani families.

Methods: The current study included consanguineous Pakistani families with at least two affected members. DNA was extracted from whole blood samples by the phenol-chloroform method. Two affected members from each family were initially analyzed using targeted panel sequencing of 344 …

Nanoparticle Contrast-Enhanced Computed Tomography Of Sporadic Aortic Aneurysm And Dissection: Effect Of Nanoparticle Size And Contrast Agent Dose, Laxman Devkota, Chen Zhang, Deborah Vela, Poonam Sarkar, Prajwal Bhandari, Zbigniew Starosolski, Renuka Menon, Dianna M Milewicz, Ying H Shen, Scott A Lemaire, Ketan B Ghaghada

Faculty, Staff and Students Publications

Background: Aortopathies, such as aortic aneurysm and dissection (AAD), are associated with enhanced aortic wall permeability and endothelial dysfunction. We previously demonstrated that nanoparticle contrast-enhanced computed tomography (nCECT), which detects enhanced aortic wall permeability, could enable non-invasive detection of early AAD before its progresses to fatal aortic rupture. This study investigated the effect of nanoparticle contrast agent (NPCA) size and dose on detection of aortopathy by nCECT.

Methods: In vivo studies were performed in a mouse model of sporadic AAD induced by challenging animals with high fat diet (5 weeks) and angiotensin II infusion (last one week). The effects …

Assessing The Cardioprotective Effects Of Exercise In Apoe Mouse Models Using Deep Learning And Photon-Counting Micro-Ct, Alex J Allphin, Rohan Nadkarni, Zay Y Han, Darin P Clark, Ketan B Ghaghada, Alexandra Badea, Cristian T Badea

Faculty, Staff and Students Publications

Background: The allelic variations of the apolipoprotein E (APOE) gene play a critical role in regulating lipid metabolism and significantly impact cardiovascular disease risk (CVD). This study aimed to evaluate the impact of exercise on cardiac structure and function in mouse models expressing different APOE genotypes using photon-counting computed tomography (PCCT) and deep learning-based segmentation.

Methods: A total of 140 mice were grouped based on APOE genotype (APOE2, APOE3, APOE4), sex, and exercise regimen. All mice were maintained on a controlled diet to isolate the effects of exercise. Low dose cardiac photon counting micro-CT imaging with intrinsic gating was performed …

Structural Dynamics And Binding Of Caenorhabditis Elegans Lifespan-Extending Lipid Binding Protein-3 To Polyunsaturated Fatty Acids, André R Cuevas, Matthew C Tillman, Meng C Wang, Eric A Ortlund

Faculty, Staff and Students Publications

Intracellular lipid binding proteins (iLBPs) play crucial roles in lipid transport and cellular metabolism across the animal kingdom. Recently, a fat‐to‐neuron axis was described in Caenorhabditis elegans, in which lysosomal activity in the fat liberates polyunsaturated fatty acids (PUFAs) that signal to neurons and extend lifespan with durable fecundity. In this study, we investigate the structure and binding mechanisms of a lifespan‐extending lipid chaperone, lipid binding protein‐3 (LBP‐3), which shuttles dihomo‐γ‐linolenic (DGLA) acid from intestinal fat to neurons. We present the first high‐resolution crystal structure of LBP‐3, which reveals a classic iLBP fold with an unexpected and unique homodimeric …

Averting Collapse: Reimagining The Ntds Ecosystem Through G20 Health Diplomacy And Science Innovation, Maple Goh, Peter J Hotez

Faculty, Staff and Students Publications

The recent termination of the U.S. Government's neglected topical diseases (NTD) mass treatment program, following similar cuts by the UK, threatens decades of progress. Without a strategic reset, NTDs may re-emerge, exacerbating poverty across Africa and beyond. We call for a broadened donor base and reframing NTD control as a shared global interest, especially as NTDs rise in G20 nations due to climate change and urbanization. This moment demands investment in sustainable tools, like NextGen vaccines and biologics, and greater leadership from G20 countries. While USAID's exit is a setback, opportunities arise for decolonizing global health and fostering new partnerships.

Towards A Map Of The Immune System Manipulation Network By Trypanosoma Cruzi, Juan Cruz Gamba, Ana Rosa Pérez, Carolina Verónica Poncini, Cristina Poveda, Iván Marcipar, Gabriel Cabrera

Faculty, Staff and Students Publications

No abstract provided.

Incidence And Outcomes Of Hospitalized Acute Ischemic Stroke Patients With Subsequent St-Segment-Elevation Myocardial Infarction, Arhum Mahmood, Song Peng Ang, Yusuf Kamran Qadeer, Hafeez Ul Hassan Virk, Jonathan Alan Tangsrivimol, Iqra Riaz, Zhen Wang, Mahboob Alam, Markus Strauss, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Background: Patients admitted with acute ischemic stroke (AIS) may experience accompanying acute ST-Segment myocardial infarction after AIS. The cardiovascular risks, incidence, complications, and outcomes of acute STEMI in patients hospitalized with AIS remains underexplored.

Methods: We evaluated 2,804,819 patients that presented with AIS who were listed in the National Inpatient Sample from 2016 to 2021. AIS and STEMI were defined according to the ICD-10 Diagnostic Codes. Patients with Non-STEMI were excluded. The risk of specific complications and outcomes were expressed as percentages. Multivariable logistic regression analysis was used to examine the association of STEMI with a primary outcome of mortality …

Stent Thrombosis: A Contemporary Guide To Definitions, Risk Factors, And Management, Ambre Flowers, Bernard Evenhuis, Benjamin Gabanic, Allison Weiss, Scott Eisenberg, Riyan Siddiqui, Affan Rizwan, Iqra Riaz, Hafeez Ul Hassan Virk, Mahboob Alam, Muzamil Khawaja, Markus Strauss, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Stent thrombosis remains a major complication following percutaneous coronary intervention, with significant morbidity and mortality implications. Despite advancements in drug-eluting stents and optimized pharmacotherapy, real-world registry data indicate that definite or probable stent thrombosis occurs in approximately 0.5% of percutaneous coronary intervention cases, with a 30-day mortality rate approaching 25% and a long-term risk exceeding 30% at 10 years. Stent thrombosis is classified based on timing into acute, subacute, late, and very late thrombosis, with subacute and very late stent thrombosis being the most prevalent. Clinical consequences include myocardial infarction, emergent revascularization, and heightened cardiovascular risk, necessitating timely recognition and …

Structural Heart Imaging Using 3-Dimensional Intracardiac Echocardiography: Jacc: Cardiovascular Imaging Position Statement, Gilbert H L Tang, Syed Zaid, Rebecca T Hahn, Vratika Aggarwal, Mohamad Alkhouli, Edris Aman, Sergio Berti, Y S Chandrashekhar, Scott M Chadderdon, Andreina D'Agostino, Neil P Fam, Edwin C Ho, Chad Kliger, Susheel K Kodali, Parasuram Krishnamoorthy, Azeem Latib, Stamatios Lerakis, D Scott Lim, Vaikom S Mahadevan, Devi G Nair, Jagat Narula, Patrick T O'Gara, Douglas L Packer, Fabien Praz, Jason H Rogers, Tobias F Ruf, Carlos E Sanchez, Alok Sharma, Gagan D Singh, Nicolas M Van Mieghem, Mani A Vannan, Pradeep K Yadav, Lina Ya'qoub, Firas E Zahr, Ralph Stephan Von Bardeleben

Faculty, Staff and Students Publications

3-dimensional (3D) intracardiac echocardiography (ICE) is emerging as a promising complement and potential alternative to transesophageal echocardiography for imaging guidance in structural heart interventions. To establish standardized practices, our multidisciplinary expert position statement serves as a comprehensive guide for the appropriate indications and utilization of 3D-ICE in various structural heart procedures. The paper covers essential aspects such as the fundamentals of 3D-ICE imaging, basic views, and workflow recommendations specifically tailored for ICE-guided structural heart procedures, such as transeptal puncture, device closure of intracardiac structures, and transcatheter mitral and tricuspid valve interventions. Current challenges, future directions, and training requirements to ensure …

Testosterone Plus Lifestyle Therapy Improves Skeletal Muscle Glycolysis In Older Men With Obesity And Hypogonadism, Viola Viola, Marlene Aguilar, Maria Liza Duremdes Nava, Alessandra Celli, Reina Armamento-Villareal, Yoann Barnouin, Nicola Napoli, Nagireeddy Putluri, Clifford Qualls, Dennis T Villareal

Faculty, Staff and Students Publications

Objective: Weight loss in older men with obesity and hypogonadism accelerates musculoskeletal decline, yet the underlying metabolic mechanisms remain unclear. Testosterone replacement therapy (TRT), when added to lifestyle therapy (LT), mitigates this decline, but its metabolic basis has not been defined. We examined skeletal muscle metabolomic adaptations to LT with or without TRT, focusing on glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, and carnitine metabolism to identify dominant pathways of metabolic adaptation.

Design: Randomized, double-blind, placebo-controlled trial (LITROS).

Methods: Eighty-three men aged 65 years or older with obesity (BMI ≥30 kg/m2), hypogonadism (testosterone < 10.4 nmol/L), and frailty (Physical Performance Test score ≤31) were randomized to 26 weeks of LT plus TRT (LT+TRT) or LT plus placebo (LT+Pbo). A metabolomic substudy was performed in 44 participants, who underwent serial biopsies of the vastus lateralis for targeted LC-MS/MS analysis of intermediates in glycolysis, PPP, TCA cycle, and carnitine metabolism.

Results: Among the …

Clues To Transcription/Replication Collision-Induced Dna Damage: It Was Rnap, In The Chromosome, With The Fork, Matthew B Cooke, Christophe Herman, Priya Sivaramakrishnan

Faculty, Staff and Students Publications

DNA replication and RNA transcription processes compete for the same DNA template and, thus, frequently collide. These transcription-replication collisions are thought to lead to genomic instability, which places a selective pressure on organisms to avoid them. Here, we review the predisposing causes, molecular mechanisms, and downstream consequences of transcription-replication collisions (TRCs) with a strong emphasis on prokaryotic model systems, before contrasting prokaryotic findings with cases in eukaryotic systems. Current research points to genomic structure as the primary determinant of steady-state TRC levels and RNA polymerase regulation as the primary inducer of excess TRCs. We review the proposed mechanisms of TRC-induced …

Folate Receptor Β Performs An Immune Checkpoint Function In Activated Macrophages, Fenghua Zhang, Md Yusuf Al-Amin, Sagar Utturkar, Rina Jiang, Gregory Cresswell, Rami Alfar, Ian Ophaug-Johansen, Gabriel Bachman, Madduri Srinivasarao, Richard Finnell, Amaya Puig-Kröger, Timothy Ratliff, Philip S Low

Faculty, Staff and Students Publications

Monocytes and macrophages are sentinels of the immune system that distinguish themselves from other cells by expressing the beta isoform of the folate receptor (FRβ). Because FRβ does not bind folate until the monocyte/macrophage is exposed to immunosuppressive cytokines, the question naturally arose whether FRβ might also perform an immune-related function. To examine this matter, we compared the properties of wild type (WT) and FRβ knockout mice. We observe that FRβ knockout (KO) mice display autoimmune symptoms that can include alopecia, enlarged spleens, and dermatitis, despite having normal cellular folate levels. We further demonstrate that syngeneic tumors (TRAMP C2, MC38) …

Ethno-Psychometry: The Measurement Of Personality In Mexico, Rolando Diaz-Loving

Online Readings in Psychology and Culture

Following in the tradition of ethno-psychological research proposed by Diaz-Guerrero (1986, 1989, 1993, 1994, 1995), this manuscript delineates the process toward obtaining statistically and conceptually valid and reliable personality measures, that at the same time are also culturally relevant and sensitive to the Mexican culture. The methods and construct development for the creation of multidimensional measures of achievement orientation, empathy, locus of control, assertiveness, masculinity, femininity, and self-concept are presented. Further information on the specific characteristics of measures, their construct and convergent, divergent, and predictive validity can be found in Diaz-Loving (2019).

Barriers And Motivators To Attending Group Exercise Classes In Women With Anxiety, Depression And Post-Traumatic Stress Disorder, Sarah Ford

Theses: Doctorates and Masters

Research has demonstrated the positive effect of exercise on mental health disorders such as anxiety disorder, depression and post-traumatic stress disorder. Studies have also investigated the barriers and motivators that women in particular experience when contemplating the ways in which to engage in physical activity. However, a literature gap exists regarding women who experience anxiety disorder, depression and post-traumatic stress disorder, and the barriers and motivators that they specifically navigate when looking to attend group exercise classes. In this body of research for the award of Master of Medical and Health Science by Research, a scoping review was first conducted …

Early, Standardised, And Precise Treatment Of Copd Exacerbations And Covid-19, Sanjay Ramakrishnan

Theses: Doctorates and Masters

Background: Background Chronic Obstructive Pulmonary Disease (COPD) is a common chronic condition causing significant morbidity and mortality. Patients with COPD report sudden episodes of deteriorating respiratory symptoms called exacerbations, often presumed to be precipitated by infections. COPD is in the top 5 causes of death globally. COPD exacerbations drive a large proportion of these deaths. Despite this, there is no standardised model of care for the sickest patients who need hospitalisations for exacerbations. Meanwhile, treatment for COPD exacerbations continues to be guided by symptoms, instead of underlying biology. Most patients are treated with unnecessary and harmful systemic corticosteroids. During the …

Return Serve: Exploring The Dialogism Of The Australia-China Relationship In Media Coverage Between 2020-2022, Jordan Hogan

Theses: Doctorates and Masters

Australia and the People’s Republic of China (PRC) have a dynamic bilateral relationship that is defined by interdependency and mutual political scepticism. This thesis provides an analysis of Australian and Chinese news media perspectives on this relationship. Via an in-depth examination of opinion pieces from national press, I map the significant developments of a period of deteriorating relations between 2020 and 2022. My study captures the more prominent, parochial and vitriolic media coverage of the unravelling relationship, and investigates the motivations, developments, differences, and similarities in the online publications of Australia’s national daily newspaper The Australian, and China’s Global Times. …

The Role Of Game-Based Learning Simulation To Enhance Leadership In Pandemic Preparedness For Nursing Students, Scott James Andrews

Theses: Doctorates and Masters

During the COVID-19 pandemic, nurses around the world suffered with the impact of resource scarcity on the provision of quality nursing care to patients. Nursing staff were at higher risk of infection than all other healthcare workers, with working conditions during the pandemic resulting in significant staffing pressures. The challenges faced by staff during the pandemic inevitably influenced the quality and delivery of clinical education, highlighting the need for innovative solutions such as digital learning to address emerging training needs. Further, the impact of COVID-19 restrictions on clinical education has highlighted the benefits of digital learning environments as alternatives to …

Factors Associated With Contraceptive Discontinuation Among Women In The U.S., Moradi Aljadani

Electronic Theses and Dissertations 2020 - Present

Background: Contraceptive discontinuation is a significant public health concern in the United States, contributing to unintended pregnancies and associated health, social, and economic consequences. Despite the availability of a wide range of contraceptive methods, many women discontinue use prematurely due to a variety of personal, social, cultural, and systemic factors. However, limited research has comprehensively examined these factors at the national level, particularly within a theoretical framework that captures the multidimensional influences on contraceptive decision-making. Objective: This study aimed to assess the factors associated with contraceptive method discontinuation among women in the U.S, guided by Ray’s Theory f …

“Thank You For Hearing Me”: Listening To Stories Of Linguicism, Caroline Asher Webb

Electronic Theses and Dissertations 2020 - Present

This dissertation examines the effects of linguicism on nonnative speakers of English who are currently studying in higher education in the United States or other English-dominant countries. Linguicism, also called linguistic discrimination, others and discriminates against people based on their oral or written language use. Rooted in master narratives of Standard English, monolingualism, and the native speaker, linguicism, unlike other forms of discrimination, such as gender or racial discrimination, is subtle and unmarked, thus permeating the consciousness of even the most well-intentioned of people.

Using a Critical Race Theory framework, the present study utilized a storytelling methodology to gather first-hand …

The Souls Of Black Ghosts: Centering Intergenerational Trauma Of Black Americans From Harriet Tubman To Beloved, Jasmine Mccray

Electronic Theses and Dissertations 2020 - Present

Intergenerational trauma is being debated and researched in fields such as neuroscience and sociology, and yet many question whether one can genuinely feel the negative effects of a lived experience from a distant ancestor. This project aims to raise awareness on the attempts at erasing Harriet Tubman’s heritage through scholarship on her disability, and to highlight the presence of intergenerational trauma (as defined by Dr. DeGruy’s observations in Post-Traumatic Slave Syndrome) in Toni Morrison’s Beloved. I note the ripple effects of chattel slavery in the United States seen in the consciousness and unconsciousness of Black Americans within a …

Age-Group Differences In Friend Influence Over Academic Achievement And Physical Activity, Laury-Ann Bedard Leclerc

Electronic Theses and Dissertations 2020 - Present

Speculation about the developmental shifts in the magnitude of peer influence has outstripped empirical research. Friends are assumed to be particularly influential at the onset of adolescence, as adult oversight declines and the salience of peers increases. Few studies, however, have explored age-group differences in the magnitude of friend influence over academic achievement and physical activity. The present longitudinal study compares friendship dyads in late childhood (grades 4-5) versus early adolescence (grades 6-7), describing the strength of their mutual influence across peer- and self-reports of academic achievement and physical activity. Participants included 170 adolescents (99 girls, 71 boys) in 85 …

Meta’S Ai Bias To What Extent Do Meta's Algorithmic Processes For Classifying And Processing Information Related To Acts Of Racism Impact Fairness, Bias, And Social Justice Across Its Platforms?, Shanique Foster

Electronic Theses and Dissertations 2020 - Present

Algorithmic processing and classification of racism-related content have become increasingly prevalent across Meta's platforms. While these algorithms aim to create safer online environments, their effectiveness and impact on fairness remain understudied. This research examines how Meta's algorithmic processes for classifying racist content affect fairness, bias, and social justice across Facebook, Instagram, and WhatsApp.

Using qualitative research methodology, the study conducted focus groups with diverse platform users to understand their experiences with content moderation. The research also analyzed theoretical frameworks related to algorithmic bias, fairness metrics, and social justice in digital spaces.

Key findings revealed significant variations in algorithmic effectiveness across …

The Politics Of Housing Exploitation Power, Resistance, And Compliance In Florida’S Post-Covid Affordable Housing Crisis, Annabelle Campbell

Electronic Theses and Dissertations 2020 - Present

By the time of the 2022 midterm elections, housing affordability had become a prominent policy issue in Florida, as post-COVID economic conditions, including rising rents and inflation, heightened political attention and debate at the local level. Two counties—Palm Beach County and Orange County—became focal points of this debate, each introducing a ballot referendum offering divergent solutions to local housing affordability challenges. Palm Beach County pursued a market-driven approach, passing a $200 million housing bond to incentivize private-sector development, while Orange County attempted a regulatory intervention through a rent stabilization ordinance, directly challenging Florida’s dominant pro-growth housing framework.

This dissertation examines …

The Rise And Resilience Of Women Of Color Executives In Nonprofit Organizations: A Phenomenological Study Of Systemic Barriers, Support Systems And Leadership Identity, Nicole Edwards

Electronic Theses and Dissertations 2020 - Present

This phenomenological study explored the lived experiences of women of color executive leaders in nonprofit organizations, focusing on perceptions of systemic barriers, support systems, and leadership identity. Using a mixed-methods, phenomenological design, data were collected from 31 women of color (N = 31) through a Likert-type survey and from six women (n = 6) selected for semi-structured interviews.

Quantitative analysis revealed that perceived systemic barriers significantly predicted leadership identity (p = .013), while support systems did not. Further analysis uncovered a significant positive correlation between positional status and perceived support (r = .39, p = .050), indicating …

Psychometric Properties Of A New Acculturation Scale For Latinos/Hispanics, Alicia Goytizolo

Electronic Theses and Dissertations 2020 - Present

The current study evaluated the psychometric properties of the newly developed Multi-Ethnic Acculturation Scale (MAS), a multidimensional instrument designed to assess behavioral and cognitive aspects of cultural adaptation among Hispanic/Latino individuals in the United States. A sample of 208 adults from diverse Hispanic backgrounds completed the MAS alongside two validated acculturation measures: the Short Acculturation Scale for Hispanics and the Vancouver Index of Acculturation. Exploratory factor analyses revealed a partially distinct but moderately correlated factor structure for both American and Latino cultural orientation subscales, supporting a bidimensional conceptualization of acculturation. Internal consistency was high across both subscales (Cronbach’s α > .90), …

Does Federal Funding Address Fundamentals? Examining The Equity Effects Of Title I On Student Achievement, Veda Hudge

Electronic Theses and Dissertations 2020 - Present

This dissertation examines the equity effects of Title I funding on student achievement in Broward County Public Schools, one of the largest school districts in the United States. Title I, established under the Elementary and Secondary Education Act (ESEA) of 1965, aims to address educational disparities by providing financial resources to schools that serve economically disadvantaged students. Despite over five decades of federal intervention, significant achievement gaps persist, particularly among marginalized populations. This study investigates the effectiveness of Title I funding in improving student outcomes in English Language Arts (ELA) and Mathematics during the period 2016–2020.

Using a quantitative research …

Institutional Learning And International Student Enrollment: A Case Study Of Perceptions Of Practice, Debra Szabo

Electronic Theses and Dissertations 2020 - Present

This dissertation examines the application of Peter Senge’s Learning Organization Theory at Florida Atlantic University (FAU), focusing on administrators' perceptions of institutional learning amid increasing international student enrollment. Higher education institutions must balance market-driven behaviors with collaborative learning environments as they navigate a competitive global landscape.

The study stresses the need to investigate institutional learning outcomes and the impact of rising international student enrollment on university policies, procedures, and organizational learning. It explores the relationship between espoused theories, strategic goals designated by FAU, and theories-in-action, which reflect actual practices in recruiting and supporting international students. By integrating Argyris and Schön's …

Balancing Risk And Reward: Health Insurance And The Financial Stability Of Female Entrepreneurs With Children, Leeanne Lowe Aguilar

Electronic Theses and Dissertations 2020 - Present

This study examines the specific influence of health insurance on female entrepreneurs with children, a demographic that has been underexplored in existing research on health insurance and entrepreneurship. The aim is to evaluate whether access to health insurance significantly affects these entrepreneurs' business decisions, financial stability, and overall well-being.

Grounded in job-lock theory and evidence of the gender gap, the research hypothesizes that health insurance enhances entrepreneurial performance, particularly benefiting women with children. It anticipates that female entrepreneurs will encounter more significant challenges than their male counterparts and that those with children may face additional performance barriers, especially when lacking …