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2025

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“Always Looking Over Your Shoulder”: College Students' Experiences With Codes Of Conduct At Evangelical Colleges & Universities, Kayla B. Powell Jan 2025

“Always Looking Over Your Shoulder”: College Students' Experiences With Codes Of Conduct At Evangelical Colleges & Universities, Kayla B. Powell

Theses and Dissertations--Educational Policy Studies and Evaluation

This qualitative research study investigated the experiences of college students enrolled at evangelical institutions that are affiliated with the Council for Christian Colleges & Universities (CCCU) and require students to follow an extensive code of conduct. These codes extend beyond academic expectations and mandate behavior in all aspects of daily life. Students who fail to comply are subject to a range of punishments as severe as expulsion. Sixteen traditional-aged undergraduate students from across the U.S. participated in semi-structured interviews that were analyzed using thematic analysis. Students described varied personal convictions regarding the rules; some earnestly strove to obey their campus …


Investigating The Psychometric Properties Of A Set Of Local Stem Literacy Instruments In Rasch Model, Lijun Shen Jan 2025

Investigating The Psychometric Properties Of A Set Of Local Stem Literacy Instruments In Rasch Model, Lijun Shen

Theses and Dissertations--Educational Policy Studies and Evaluation

This study investigates the psychometric features of the See Blue STEM literacy inventories (SBSTEMs, including the elementary version SB-E and the middle school version SB-M) to determine their validity in measuring STEM literacy. Using data from elementary and middle school students participating in the See Blue STEM camp in 2019 and 2021-22, this research employed the Rasch Partial Credit Model (PCM) to analyze item-level performance and identify DIF items across various demographic subgroups (race, gender, free-lunch status, and potential first-generation status) and camp delivery modes (online versus in-person). Results indicated that both the elementary (SB-E) and middle school (SB-M) versions …


From Disciplinary Enthusiasm To Soulless Tasks: Norms Behind Computing Educators' Emotion Display, Virginia Grande, Päivi Kinnunen, Matthew Barr, Anne Kathrin Peters, Mihaela Sabin, Matilde Sánchez-Peña, Ethel Tshukudu Jan 2025

From Disciplinary Enthusiasm To Soulless Tasks: Norms Behind Computing Educators' Emotion Display, Virginia Grande, Päivi Kinnunen, Matthew Barr, Anne Kathrin Peters, Mihaela Sabin, Matilde Sánchez-Peña, Ethel Tshukudu

Faculty Research, Scholarly, and Creative Activity

Computing educators' emotion display is regulated by various norms and conventions. These (unwritten) rules affect which emotions educators feel comfortable expressing to different extents when students can perceive such displays. We draw on emotions and norms literature to investigate higher education computing educators' perceptions of what kinds of norms they have as criteria when considering which emotions they are (not) comfortable showing when teaching. Based on the qualitative content analysis of 22 interviews with computing educators from seven countries, we present various–sometimes connected or conflicting–norms that influence emotion display. These norms comprise moral, national, societal, professional, and affiliation norms that …


Competent Readers’ Online Multimodal Reading Strategies Use, Hyoju Ahn Jan 2025

Competent Readers’ Online Multimodal Reading Strategies Use, Hyoju Ahn

Faculty Articles, Papers, and Other Scholarship

As reading spaces evolve, it is imperative to identify and describe the strategies and skills used in constructing meaning. I examined online multimodal reading strategies, those used in constructing meaning from multimodal information sources (e.g., images, audio, written words) on the Internet. Participants read online multimodal texts from a laptop screen and provided verbal reports as they read to learn a scientific topic. Through verbal protocol analysis, I cataloged and described their multimodal reading comprehension strategies. Complementing retrospective interviews, reader-computer interaction videos, and written pre- and post-knowledge reports accounted for how they read strategically. Strategies were coded to provide insights …


Knee Health Is A Major Determinant Of Mobility Across The Healthspan, Brandon M. Peoples, Kenneth Harrison, Michael A. Samaan, Christopher B. Mobley, David T. Redden, Jaimie A. Roper Jan 2025

Knee Health Is A Major Determinant Of Mobility Across The Healthspan, Brandon M. Peoples, Kenneth Harrison, Michael A. Samaan, Christopher B. Mobley, David T. Redden, Jaimie A. Roper

Kinesiology and Health Promotion Faculty Publications

Knee health constitutes a pivotal determinant of locomotor function and overall mobility throughout the healthspan. Impairments in knee function lead to a series of biomechanical and physiological alterations that pose substantial public health challenges and economic burdens worldwide. This review synthesizes evidence that delineates the complex and multifaceted relationship between knee health and mobility, emphasizing the interplay across various domains in adult populations. Knee health is conceptualized as a dynamic, interconnected system whereby structural integrity, neuromuscular mechanisms, biomechanical adaptations, and functional mobility are intricately interrelated through cascades of mechanistic processes operating across different temporal stages. A comprehensive understanding of these …


Examining The Professional Noticing Skills, Attitudes Toward Mathematics, And Elementary Math Content Knowledge Of Preservice Elementary School Teachers Through The Noticing Numeracy Now Intervention, Johnathan T. Rogers Jan 2025

Examining The Professional Noticing Skills, Attitudes Toward Mathematics, And Elementary Math Content Knowledge Of Preservice Elementary School Teachers Through The Noticing Numeracy Now Intervention, Johnathan T. Rogers

Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education

Abstract: This quasi-experimental study examined the impact of the Noticing Numeracy Now intervention, an intervention focused on professional noticing of children’s conceptual development in whole number and arithmetic reasoning, on preservice elementary teachers’ professional noticing skills, attitudes toward mathematics, and elementary math content knowledge. This study was based off of a previous study and intervention created by Molly Fisher, Jonathan Thomas, Edna Schack, Cindy Jong and Janet Tassell. This study used a video-based professional noticing module, consisting of four lessons, situated in the pedagogies of practice framework. Within this study, 10 students (all preservice elementary teachers) at Kentucky State University …


Aqualoop (The Four Stages Of Earth's Water Cycle), Precious Onwubuche Jan 2025

Aqualoop (The Four Stages Of Earth's Water Cycle), Precious Onwubuche

Theses

This research investigates the development of an educational initiative that illustrates the water cycle using real-life simulations and moving graphics targeting high school students and older audiences to connect theoretical knowledge with hands-on learning in Earth science education. The initiative utilises visual design strategies to turn intricate hydrological processes into an engaging educational journey. The significance of this project is underscored by statistics showing that fewer than 30 percent of secondary school students master Earth science principles, such as the water cycle. This is based on 2019 information from the National Assessment of Educational Progress (NAEP). Additionally, and notably, more …


Leveraging Diverse Knowledge To Support Collection Development: Maximizing Student Engagement And Community Resource Value In Varied Community College Settings, Jose Aguiñaga, Edward Mckennon Jan 2025

Leveraging Diverse Knowledge To Support Collection Development: Maximizing Student Engagement And Community Resource Value In Varied Community College Settings, Jose Aguiñaga, Edward Mckennon

Faculty Research, Scholarly, and Creative Activity

No abstract provided.


“They're Like Slash”: Multimodality And Embodied Agency In Students' Critical Engagements With Texts, María José Aragón, Meghan Corella, Nora W. Lang Jan 2025

“They're Like Slash”: Multimodality And Embodied Agency In Students' Critical Engagements With Texts, María José Aragón, Meghan Corella, Nora W. Lang

Faculty Research, Scholarly, and Creative Activity

Despite recent calls to more fully incorporate multimodal perspectives into literacies research, there is still limited scholarship examining how students critically engage in reading activities by drawing on embodied practices. Racially and linguistically minoritized students are particularly disadvantaged by dominant logocentric and developmentalist approaches, which privilege oral and written discourse and often position these students as less capable of performing complex literacy practices. Drawing from three independent ethnographic studies, our multimodal interactional analysis examines how students of a range of ages and raciolinguistic backgrounds use embodied actions and other semiotic resources to agentively navigate text, task, and ideological constraints in …


Contraceptive Use Among Transgender Men And Gender Diverse Individuals In The United States: Reasons For Use, Non-Use, And Methods Used For Pregnancy Prevention, Juno Obedin-Maliver, Ava Snow, Sachiko Ragosta, Laura Fix, Jen Hastings, Micah E. Lubensky, Matthew R. Capriotti, Zubin Dastur, Annesa Flentje, Mitchell R. Lunn, Heidi Moseson Jan 2025

Contraceptive Use Among Transgender Men And Gender Diverse Individuals In The United States: Reasons For Use, Non-Use, And Methods Used For Pregnancy Prevention, Juno Obedin-Maliver, Ava Snow, Sachiko Ragosta, Laura Fix, Jen Hastings, Micah E. Lubensky, Matthew R. Capriotti, Zubin Dastur, Annesa Flentje, Mitchell R. Lunn, Heidi Moseson

Faculty Research, Scholarly, and Creative Activity

Objectives: To describe contraceptive use for pregnancy prevention among transgender men and gender diverse (TGD) individuals assigned female or intersex at birth (AFIAB) and explore whether contraceptive use differs by testosterone use. Study design: We analyzed data from a cross-sectional, online survey of N = 1694 TGD individuals AFIAB recruited in 2019 through a community-facing website and a national community-engaged cohort study of sexual and/or gender minority (SGM) adults in the US. Descriptive and regression analyses characterized the current and ever use of contraceptive methods for pregnancy prevention, stratified by testosterone use, and described reasons for contraceptive use/non-use. Results: Most …


Drip Hoses And Discipleship: Rethinking The Future Of Theological Education With Justo González, Benjamin D. Wayman Ph.D. Jan 2025

Drip Hoses And Discipleship: Rethinking The Future Of Theological Education With Justo González, Benjamin D. Wayman Ph.D.

Apuntes: Reflexiones teológicas desde el margen hispano

In early February 2020 I spent a day with Justo González at his home in Decatur, Georgia, to discuss the future of theological education. The following piece showcases the disciplined imagination of one of the greatest church historians of our generation as he explains how drip hoses, worship, baptism, online learning, and more could guide the next generation of theological educators. In what follows, the reader will get a sense for why González thinks theological education is in a place of promise rather than peril.

A principios de febrero de 2020, pasé un día con Justo González en su casa …


Tools And Methods For Cataract Recognition In Low-Resource Settings: A Narrative Review, Paulina N Truong, Elizabeth A Merlinsky, Nicholas C Maamari, Christina Y Weng, Andrew G Lee Jan 2025

Tools And Methods For Cataract Recognition In Low-Resource Settings: A Narrative Review, Paulina N Truong, Elizabeth A Merlinsky, Nicholas C Maamari, Christina Y Weng, Andrew G Lee

Faculty, Staff and Students Publications

Cataracts are a leading cause of global blindness, with many low-resource populations having poor access to eye care. While much is known regarding surgical access and outcomes, less is understood about the initial detection of operable cataracts in low-resource settings. We performed a comprehensive literature review on existing and emerging cataract screening methods in low- and middle-income countries (LMICs). The search keywords were "cataract detection, diagnosis, assessment, and evaluation in low- and middle- income countries". 1,825 articles were identified and 62 were selected for final inclusion comprising reviews, meta-analyses, and original research studies. Only 12 studies proposed new cataract screening …


The Torch: 2024-2025 In Review, College Of Arts & Sciences Honors Program Jan 2025

The Torch: 2024-2025 In Review, College Of Arts & Sciences Honors Program

Torch Newsletter

No abstract provided.


Clinical Significance Of "S" Isoform Of Dclk1 In Different Gastric Cancer Subtypes Using Newly Produced Monoclonal Antibody, Mahdieh Razmi, Ali-Ahmad Bayat, Nafiseh Mortazavi, Elham Kalantari, Leili Saeednejad Zanjani, Sima Saki, Roya Ghods, Zahra Madjd Jan 2025

Clinical Significance Of "S" Isoform Of Dclk1 In Different Gastric Cancer Subtypes Using Newly Produced Monoclonal Antibody, Mahdieh Razmi, Ali-Ahmad Bayat, Nafiseh Mortazavi, Elham Kalantari, Leili Saeednejad Zanjani, Sima Saki, Roya Ghods, Zahra Madjd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Doublecortin-like kinase 1 (DCLK1) isoforms play distinct roles in the progression of gastrointestinal cancers. For the first time ever, the current study aimed to generate DCLK1-S-specific monoclonal antibodies (mAbs) to evaluate the clinical value of DCLK1-S (short isoform) in gastric cancer (GC).

Materials and methods

Mice were immunized with a unique 7-mer synthetic peptide of DCLK1-S conjugated with keyhole limpet hemocyanin (KLH). Immunoreactivity of hybridomas and mAbs was determined by ELISA assays and immunohistochemistry (IHC). DCLK1-S expression in two GC cell lines was assessed by flow cytometry. After characterization, the expression pattern of DCLK1-S was investigated in different histological …


“I Bet Being Trans In The Netherlands Is Like Living In The Future”: Could The Netherlands Serve As An Imperfect “Gold Standard” Comparator For Transgender Youth Research In The United States?, Anna I.R. Van Der Miesen, Sharanya Rao, Abigail L. Fischbach, Alex C. Bakker, Marjolein Van Den Brink, Renata A. Sanders, Caitlin Ryan, Stephen M. Rosenthal, Joep Roeffen, Asaf Orr Esq, Heather Newby, Kathie Moehlig, Richard Mocarski, Kim Horsnell, Thijs De Greeff, Annelou L.C. De Vries, Aisa Burgwal, Owen Wilson, Annika Kooke Jan 2025

“I Bet Being Trans In The Netherlands Is Like Living In The Future”: Could The Netherlands Serve As An Imperfect “Gold Standard” Comparator For Transgender Youth Research In The United States?, Anna I.R. Van Der Miesen, Sharanya Rao, Abigail L. Fischbach, Alex C. Bakker, Marjolein Van Den Brink, Renata A. Sanders, Caitlin Ryan, Stephen M. Rosenthal, Joep Roeffen, Asaf Orr Esq, Heather Newby, Kathie Moehlig, Richard Mocarski, Kim Horsnell, Thijs De Greeff, Annelou L.C. De Vries, Aisa Burgwal, Owen Wilson, Annika Kooke

Faculty Research, Scholarly, and Creative Activity

Background: In available comparative studies, Dutch transgender youth have consistently shown better psychosocial well-being compared to those in other countries. Therefore, the Netherlands (N.L.) could be considered a gold-standard—though imperfect—comparator for transgender youth research. The United States (U.S.) is heterogeneous in its policies and practices impacting transgender youth, and policies are in flux. This study examines similarities and differences between U.S. and Dutch policies, practices, and contexts relevant to the well-being of transgender adolescents. Methods: A three-stage Delphi procedure was conducted with expert panels in the N.L. and U.S. Results: This process identified candidate mechanisms driving differences in outcomes for …


Can Household Water Sharing Advance Water Security? An Integrative Review Of Water Entitlements And Entitlement Failures, Melissa Beresford, Ellis Adams, Jessica Budds, Leila M. Harris, Wendy Jepson, Tennille Marley, Chloe Nguyen, Amber Pearson, Anaís Delilah Roque, Asher Y. Rosinger, Sameer H. Shah, Matthew Stellbauer, Amber Wutich Jan 2025

Can Household Water Sharing Advance Water Security? An Integrative Review Of Water Entitlements And Entitlement Failures, Melissa Beresford, Ellis Adams, Jessica Budds, Leila M. Harris, Wendy Jepson, Tennille Marley, Chloe Nguyen, Amber Pearson, Anaís Delilah Roque, Asher Y. Rosinger, Sameer H. Shah, Matthew Stellbauer, Amber Wutich

Faculty Research, Scholarly, and Creative Activity

An increasing number of studies find that water sharing—the non-market transfer of privately held water between households—is a ubiquitous informal practice around the world and a primary way that households respond to water insecurity. Yet, a key question about household water sharing remains: is water sharing a viable path that can help advance household water security? Or should water sharing be understood as a symptom of water insecurity in wait for more formalized solutions? Here, we address this question by applying Sen’s entitlement framework in an integrative review of empirical scholarship on household water sharing. Our review shows that when …


Optogenetic Methods To Stimulate Gamma Motor Neuron Axons Ex Vivo, Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson Jan 2025

Optogenetic Methods To Stimulate Gamma Motor Neuron Axons Ex Vivo, Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson

Faculty Research, Scholarly, and Creative Activity

It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to monitor muscle spindle afferent firing, which should increase in response to gamma motor neuron-induced lengthening of the sensory region of the muscle spindle. A force transducer measured alpha motor neuron-mediated twitch contractions. Blue LED light (470 nm; 1–5 mW) was delivered via a light guide to the sciatic …


Association Of Helicobacter Pylori Infection With Pediatric Asthma In Palestine, Alaa Hrizat, Amal A Shahin, Banan M Mafarjeh, Mohammad A Atawneh, Kamel Gharaibeh, Nisreen Rumman, Mutaz Sultan Jan 2025

Association Of Helicobacter Pylori Infection With Pediatric Asthma In Palestine, Alaa Hrizat, Amal A Shahin, Banan M Mafarjeh, Mohammad A Atawneh, Kamel Gharaibeh, Nisreen Rumman, Mutaz Sultan

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Purpose: Significant debate exists on the association between Helicobacter pylori infection and childhood asthma. We aimed to explore this association in a cohort of children in Palestine while estimating the prevalence of H. pylori in this population. Methods: We conducted a prospective case-control study among children aged 6–15 years in Palestine, including 44 asthma cases diagnosed by pediatric pulmonologists and 99 age-matched healthy controls recruited through cluster sampling from schools. H. pylori status was determined using a stool antigen test. Asthma severity was assessed using the International Study of Asthma and Allergies in Childhood questionnaire. Data on recent antibiotic use, …


Comprehensive Investigation Of Proteoglycan Gene Expression In Breast Cancer: Discovery Of A Unique Proteoglycan Gene Signature Linked To The Malignant Phenotype, Simone Buraschi, Gabriel Pascal, Federico Liberatore, Renato V. Iozzo Jan 2025

Comprehensive Investigation Of Proteoglycan Gene Expression In Breast Cancer: Discovery Of A Unique Proteoglycan Gene Signature Linked To The Malignant Phenotype, Simone Buraschi, Gabriel Pascal, Federico Liberatore, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Solid tumors present a formidable challenge in oncology, necessitating innovative approaches to improve therapeutic outcomes. Proteoglycans, multifaceted molecules within the tumor microenvironment, have garnered attention due to their diverse roles in cancer progression. Their unique ability to interact with specific membrane receptors, growth factors, and cytokines provides a promising avenue for the development of recombinant proteoglycan-based therapies that could enhance the precision and efficacy of cancer treatment. In this study, we performed a comprehensive analysis of the proteoglycan gene landscape in human breast carcinomas. Leveraging the available wealth of genomic and clinical data regarding gene expression in breast carcinoma and …


Proper Conjugation Of Bodies: Chastity, Age, And Care Work In Sri Lankan Migrants’ Families, Michele Ruth Gamburd Jan 2025

Proper Conjugation Of Bodies: Chastity, Age, And Care Work In Sri Lankan Migrants’ Families, Michele Ruth Gamburd

Anthropology Faculty Publications and Presentations

Physical and symbolic aspects of bodies limit the migration trajectories of female domestic workers from a Buddhist community in coastal Sri Lanka. Government regulations and family decisions regarding women’s overseas labour draw upon and in turn influence discourses about gender, sexuality, age, health, and class. This ethnographic analysis illustrates that local norms task women with nurturing the brains of babies, preserving the chastity of teenage daughters, caring for frail elders, and preventing their working-class husbands from overindulging in liquor or having sex with other women. Successful social reproduction depends on the proper conjunctions of bodies in the extended family. Corporeal …


Differences In Long Covid Severity By Duration Of Illness, Symptom Evolution, And Vaccination: A Longitudinal Cohort Study From The Inspire Group, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Sharon Saydah, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein Jan 2025

Differences In Long Covid Severity By Duration Of Illness, Symptom Evolution, And Vaccination: A Longitudinal Cohort Study From The Inspire Group, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Sharon Saydah, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein

Department of Emergency Medicine Faculty Papers

Background: Although short-term outcomes of Long COVID have been described, longer-term physical and mental health outcomes of Long COVID are less well-established. This study sought to assess differences in long-term physical and mental health outcomes extending up to three years among those with current, resolved, and no Long COVID, as well as duration of Long COVID and vaccination status. Methods: This was a prospective, multisite, study of participants with SARS-CoV-2 infection from 12/7/2020-8/29/2022, with data collected through 4/2/2024. Surveys included validated tools for physical and mental health. Data were analyzed by Long COVID status (never-had, resolved, current), Long COVID duration …


The Statewide Standard, 2025, Illinois State University Jan 2025

The Statewide Standard, 2025, Illinois State University

The Statewide Standard

Annual newsletter of the Illinois State University College of Education


Structural Originalism: A Second Amendment Case Study, Ian C. Bartrum Jan 2025

Structural Originalism: A Second Amendment Case Study, Ian C. Bartrum

Scholarly Works

“Originalism” is having a national moment, even if it is not entirely clear what the word means. What should we be originalist about? The leading academic approach asks us to parse the communicative content of text ratified in a very different linguistic culture; then construct a modern legal meaning consistent with our semantic speculations. Too often the result enforces policy judgments made in a radically different moral and technological world. This makes very little sense.

In this paper I recommend a more perspicuous and coherent use of constitutional history, which I call “structural originalism.” Rather than saddle ourselves with the …


The Dna Demethylase Tet1 Modifies The Impact Of Maternal Folic Acid Status On Embryonic Brain Development, Lehua Chen, Bernard K Van Der Veer, Qiuying Chen, Spyridon Champeris Tsaniras, Wannes Brangers, Harm H M Kwak, Rita Khoueiry, Yunping Lei, Robert Cabrera, Steven S Gross, Richard H Finnell, Kian Peng Koh Jan 2025

The Dna Demethylase Tet1 Modifies The Impact Of Maternal Folic Acid Status On Embryonic Brain Development, Lehua Chen, Bernard K Van Der Veer, Qiuying Chen, Spyridon Champeris Tsaniras, Wannes Brangers, Harm H M Kwak, Rita Khoueiry, Yunping Lei, Robert Cabrera, Steven S Gross, Richard H Finnell, Kian Peng Koh

Faculty, Staff and Students Publications

Folic acid (FA) is well known to prevent neural tube defects (NTDs), but we do not know why many human NTD cases still remain refractory to FA supplementation. Here, we investigate how the DNA demethylase TET1 interacts with maternal FA status to regulate mouse embryonic brain development. We determined that cranial NTDs display higher penetrance in non-inbred than in inbred Tet1−/− embryos and are resistant to FA supplementation across strains. Maternal diets that are either too rich or deficient in FA are linked to an increased incidence of cranial deformities in wild type and Tet1+/− offspring and to …


Goldenbraid20 E Coli: A Comprehensive And Characterized Toolkit For Enterics, Matthew B Cooke, Kobie T Welch, Laura D Ramirez, Alice X Wen, David C Marciano, Christophe Herman Jan 2025

Goldenbraid20 E Coli: A Comprehensive And Characterized Toolkit For Enterics, Matthew B Cooke, Kobie T Welch, Laura D Ramirez, Alice X Wen, David C Marciano, Christophe Herman

Faculty, Staff and Students Publications

Modular cloning systems streamline laboratory workflows by consolidating genetic 'parts' into reusable and modular collections, enabling researchers to fast-track strain construction. The GoldenBraid 2.0 modular cloning system utilizes the cutting property of type IIS restriction enzymes to create defined genetic 'grammars', which facilitate the reuse of standardized genetic parts and assembly of genetic parts in the right order. Here, we present a GoldenBraid 2.0 toolkit of genetic parts designed to accelerate cloning in the model bacterium


Refugee Law: Human Rights, Refugee Law, And Border Crossing, Moria Paz Jan 2025

Refugee Law: Human Rights, Refugee Law, And Border Crossing, Moria Paz

The Judges' Book

No abstract provided.


Building Toward A Standard Model For Perinatal Mental Healthcare, R Christopher Sheldrick, Megan Deichen Hansen, Nicole H Cirino, Mary Kimmel, Courtney King, Deirdre Logan, Rena Menke, Karen Tabb Jan 2025

Building Toward A Standard Model For Perinatal Mental Healthcare, R Christopher Sheldrick, Megan Deichen Hansen, Nicole H Cirino, Mary Kimmel, Courtney King, Deirdre Logan, Rena Menke, Karen Tabb

2020-Current year OA Pubs

BACKGROUND: Healthcare decision-making relies on models that synthesize complex components such as disease epidemiology, diagnostic accuracy, and treatment efficacy. A healthcare model serves as a framework to integrate health systems research, biological understanding, and diverse perspectives on health, enabling decision-makers to optimize access, quality, cost, and equity. The National Academy of Sciences, Engineering, and Medicine (NASEM) has underscored the need for a shared conceptualization in behavioral sciences to unify definitions and facilitate data synthesis. To achieve this, a standard model of perinatal mental healthcare is imperative.

OBJECTIVE: We propose the development of a standard model of perinatal mental healthcare, analogous …


Zic1 Is A Context-Dependent Medulloblastoma Driver In The Rhombic Lip, John J Y Lee, Ran Tao, Zhen You, Parthiv Haldipur, Anders W Erickson, Hamza Farooq, Liam D Hendriske, Namal Abeysundara, Cory M Richman, Evan Y Wang, Neha Das Gupta, Jennifer Hadley, Melissa Batts, Christopher W Mount, Xiaochong Wu, Alex Rasnitsyn, Swneke Bailey, Florence M G Cavalli, Sorana Morrissy, Livia Garzia, Kulandaimanuvel Antony Michealraj, Abhi Visvanathan, Vernon Fong, Jonelle Palotta, Raul Suarez, Bryn G Livingston, Miao Liu, Betty Luu, Craig Daniels, James Loukides, Anne Bendel, Pim J French, Johan M Kros, Andrey Korshunov, Marcel Kool, Fernando Chico Ponce De León, Mario Perezpeña-Diazconti, Boleslaw Lach, Sheila K Singh, Sarah E S Leary, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji-Yeoun Lee, Teiji Tominaga, William A Weiss, Joanna J Phillips, Shizhong Dai, Gelareh Zadeh, Ali G Saad, László Bognár, Almos Klekner, Ian F Pollack, Ronald L Hamilton, Young-Shin Ra, Wieslawa A Grajkowska, Marta Perek-Polnik, Reid C Thompson, Anna M Kenney, Michael K Cooper, Stephen C Mack, Nada Jabado, Mathieu Lupien, Marco Gallo, Vijay Ramaswamy, Mario L Suva, Hiromichi Suzuki, Kathleen J Millen, L Frank Huang, Paul A Northcott, Michael D Taylor Jan 2025

Zic1 Is A Context-Dependent Medulloblastoma Driver In The Rhombic Lip, John J Y Lee, Ran Tao, Zhen You, Parthiv Haldipur, Anders W Erickson, Hamza Farooq, Liam D Hendriske, Namal Abeysundara, Cory M Richman, Evan Y Wang, Neha Das Gupta, Jennifer Hadley, Melissa Batts, Christopher W Mount, Xiaochong Wu, Alex Rasnitsyn, Swneke Bailey, Florence M G Cavalli, Sorana Morrissy, Livia Garzia, Kulandaimanuvel Antony Michealraj, Abhi Visvanathan, Vernon Fong, Jonelle Palotta, Raul Suarez, Bryn G Livingston, Miao Liu, Betty Luu, Craig Daniels, James Loukides, Anne Bendel, Pim J French, Johan M Kros, Andrey Korshunov, Marcel Kool, Fernando Chico Ponce De León, Mario Perezpeña-Diazconti, Boleslaw Lach, Sheila K Singh, Sarah E S Leary, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji-Yeoun Lee, Teiji Tominaga, William A Weiss, Joanna J Phillips, Shizhong Dai, Gelareh Zadeh, Ali G Saad, László Bognár, Almos Klekner, Ian F Pollack, Ronald L Hamilton, Young-Shin Ra, Wieslawa A Grajkowska, Marta Perek-Polnik, Reid C Thompson, Anna M Kenney, Michael K Cooper, Stephen C Mack, Nada Jabado, Mathieu Lupien, Marco Gallo, Vijay Ramaswamy, Mario L Suva, Hiromichi Suzuki, Kathleen J Millen, L Frank Huang, Paul A Northcott, Michael D Taylor

Faculty, Staff and Students Publications

Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma). Overexpression of ZIC1 suppresses the growth of group 3 medulloblastoma models, whereas it promotes the proliferation of SHH medulloblastoma precursor cells. SHH medulloblastoma ZIC1 mutants show increased activity versus wild-type ZIC1, whereas G4 medulloblastoma …


Maternal Rest Improves Growth In Small-For-Gestational-Age Fetuses (<10th Percentile), Greggory R Devore, Bardo Polanco, Wesley Lee, Jeffrey Brian Fowlkes, Emma E Peek, Manesha Putra, John C Hobbins Jan 2025

Maternal Rest Improves Growth In Small-For-Gestational-Age Fetuses (<10th Percentile), Greggory R Devore, Bardo Polanco, Wesley Lee, Jeffrey Brian Fowlkes, Emma E Peek, Manesha Putra, John C Hobbins

Faculty, Staff and Students Publications

BACKGROUND: Optimal management of fetuses diagnosed as small for gestational age based on an estimated fetal weight ofHowever, maternal bed rest has not been recommended based on the results of a randomized clinical trial that showed that maternal rest does not improve fetal growth in small-for-gestational-age fetuses. This study was conducted to revisit this question.

OBJECTIVE: This study aimed to determine whether maternal bed rest was associated with an increase in the fetal biometric parameters that reflect growth after the diagnosis of a small-for-gestational-age fetus.

STUDY DESIGN: A retrospective study was conducted on fetuses who were diagnosed as small for …


Visual Acuity, Full-Field Stimulus Thresholds, And Electroretinography For 4 Years In The Rate Of Progression Of Ush2a-Related Retinal Degeneration (Rush2a) Study, David G Birch, Peiyao Cheng, Maureen G Maguire, Jacque L Duncan, Allison R Ayala, Janet K Cheetham, Nicole R Doucet, Todd A Durham, Abigail T Fahim, Frederick L Ferris, Rachel M Huckfeldt, Michele Melia, Michel Michaelides, Mark E Pennesi, José-Alain Sahel, Katarina Stingl, Ajoy Vincent, Christina Y Weng Jan 2025

Visual Acuity, Full-Field Stimulus Thresholds, And Electroretinography For 4 Years In The Rate Of Progression Of Ush2a-Related Retinal Degeneration (Rush2a) Study, David G Birch, Peiyao Cheng, Maureen G Maguire, Jacque L Duncan, Allison R Ayala, Janet K Cheetham, Nicole R Doucet, Todd A Durham, Abigail T Fahim, Frederick L Ferris, Rachel M Huckfeldt, Michele Melia, Michel Michaelides, Mark E Pennesi, José-Alain Sahel, Katarina Stingl, Ajoy Vincent, Christina Y Weng

Faculty, Staff and Students Publications

PURPOSE: To describe progression of best-corrected visual acuity (BCVA), full-field stimulus thresholds (FST), and electroretinography (ERG) over 4 years in the

DESIGN: Prospective natural history study.

PARTICIPANTS: Participants (n = 105) with biallelic disease-causing sequence variants in USH2A and BCVA letter scores of ≥54 were included.

METHODS: BCVA, FST, fundus-guided microperimetry, static perimetry, and spectral domain OCT were performed annually and ERG at baseline and 4 years only. Mixed effects models were used to estimate annual rates of change with 95% confidence intervals. Associations of change from baseline to 4 years between BCVA, FST, ERG, and other metrics were assessed …