The Multifaceted Role Of Glutamate At Excitatory And Inhibitory Synapses, Maurice A. Petroccione

Electronic Theses & Dissertations (2024 - present)

Our thoughts, memories, and actions are finely controlled by the coordinated activity of neural circuits in the brain. Prior work has identified a multitude of molecular mechanisms that contribute to the generation of these higher order functions, yet we know very little about how our ability to learn and perform habitual actions change depending on how far neurotransmitters released from neurons can travel away from their point of release. This is the main focus of my work, which I carried out using a diverse toolbox and focusing on two brain regions: the hippocampus and the striatum. The hippocampus controls learning …

Essays On Health Economics, Quan Qi

Electronic Theses & Dissertations (2024 - present)

The first chapter examines whether Medicare Part D---the largest expansion of Medicare in recent decades---had a lasting impact on retirement behavior by providing subsidized prescription drug coverage to older adults. We employ a difference-in-difference-in-differences framework that compares changes in labor supply among individuals aged 65–68 versus 55–64 in a treatment group with employer-sponsored retiree health insurance (RHI) only until age 65, relative to a control group with lifetime RHI, before and after the 2006 implementation of Part D. Using data from Health and Retirement Study (2000-2018), we find that Part D reduces full-time employment by 6.52 percentage points among the …

Misoscale Vortices In The Eyewall Boundary Layer Of A Tropical Cyclone In A Large Eddy Simulation, Emily A. Lucy

Electronic Theses & Dissertations (2024 - present)

Since the late 1980s, there have been numerous observations of extreme updrafts, gusts, and small-scale rotation in the eyewall of tropical cyclones (TCs). Research aircraft, dropsondes, and, more recently, mobile radars have collected these observations, most often from within the boundary layer. Previous studies have documented dropsondes associated with extreme gusts and updrafts, while others have discussed specific incidents of misoscale features in tropical cyclones. Several high-resolution numerical simulations of TCs have documented similar features. This study uses one such simulation from Worsnop et al. (2017). A small but intense tropical cyclone in a quiescent environment is simulated.

This simulation …

Epithelial Responses And Remodeling In The Submandibular Gland Post-Irradiation, Victoria Gellatly

Electronic Theses & Dissertations (2024 - present)

Radiation therapy for head and neck cancer often causes irreversible salivary gland dysfunction, resulting in chronic xerostomia. Understanding the cellular and molecular mechanisms underlying this dysfunction is essential for developing regenerative therapies. Given the cellular complexity of the salivary gland single-cell RNA sequencing (scRNA-seq) provides a powerful approach to investigate cell-type-specific injury responses to ionizing radiation (IR) and uncover transcriptional changes that may be masked in bulk analyses. This study investigates the cellular and molecular responses of the murine submandibular gland (SMG) to irradiation, with a focus on epithelial loss and remodeling, and regenerative failure. In order to effectively use …

Light-Driven Chemistry: Photoswitch In Rna Activity Control And Development Of Photoredox Catalysis, Juncheng Li

Electronic Theses & Dissertations (2024 - present)

This dissertation is structured into two principal segments. The initial segment elucidates a series of synthetic works involving artificial molecules, specifically featuring the photosensitive azobenzene. These molecules facilitate remote control over the structure and functionality of biomolecules, with subsequent applications in regulating biological processes. The latter segment concentrates on the design and enhancement of organic photocatalysts, utilizing traditional acridine ions as a foundation. This section details the development of diverse organic photocatalyst-promoted processes, including photo Lewis acid catalysis, photo Brønsted acid catalysis, and photoredox reactions.

The Senior International Officer: A Sociological Perspective On The Development Of A Higher Education Profession, Mohammad Mansoor Khan

Electronic Theses & Dissertations (2024 - present)

Internationalization of higher education institutions in the United States has progressed rapidly since World War II. The pace and specifics of this internationalization vary by institution. However, there are some shared characteristics including, but not limited to, increase in student mobility, both inward and outward, exchange of scholars, cross-border research, and internationalization of the curriculum. This increased the institutional administrative burden and necessitated the centralization of internationalization activities under a single administrative unit and led by an individual capable of providing leadership at their institution in the area of higher education internationalization. This individual is recognized as the Senior International …

Non-Profit Hospital Spending On Community Health Improvement: Catalysts, Impediments, And Opportunities In New York State, Isaac H. Michaels

Electronic Theses & Dissertations (2024 - present)

This dissertation assesses the distribution and determinants of spending by non-profit hospitals in New York State on community health improvement services and community benefit operations. Utilizing the Social Ecological Model of Health, this study considers multiple levels of influence on this spending, including organizational and community characteristics. Using quantitative analysis, it examines cross-sectional, spatial, and longitudinal patterns in spending and identifies organizational and community-level factors influencing it. Qualitative analysis investigates operational factors affecting spending, including individual and interpersonal influences. The results of this mixed-methods study can inform hospital administrators, public health officials, policymakers, and communities in optimizing policies and decision-making …

Contactin2(Cntn2)Creert2 Mouse Line, A New Genetic Tool For Temporal Control To Trace The Developing Neurons In The Nose, Alexis M. Semon

Electronic Theses & Dissertations (2024 - present)

Neuronal migration is a vital process in embryonic development. In rodents, the very first neurons that originate from the olfactory placode migrate toward the developing brain as part of the migratory mass. This migratory mass includes Gonadotropin-releasing hormone-1 (GnRH-1) neurons, pioneer/terminal nerve (TN) neurons, and olfactory ensheathing cells—a type of glial cell.

Contactin-2 (Cntn2), also referred to as transiently expressed axonal surface glycoprotein-1 (TAG-1), belongs to the contactin family of proteins, which is part of the immunoglobulin superfamily of cell adhesion molecules. Cntn2 has been extensively utilized as a transient/stage-specific molecular marker for various neuronal populations, including commissural neurons of …

Development Of Dna Nanoswitches With Aptamer Based Detection For Thrombin, Camryn A. Beckles

Electronic Theses & Dissertations (2024 - present)

Bio-transducers are devices capable of converting the binding signals from molecular recognition events into readable signals for analytical detection. There is a need for modular bio-transducers that can specifically detect a wide range of analytes using a unified readout technique, as this approach could dramatically reduce costs of healthcare diagnostics and environmental monitoring.

To create such a modular transducer, the molecular recognition properties of aptamers will be used and integrated with the already established biosensing capabilities of DNA nanoswitches that reconfigure their shape in the presence of their target molecule. In this design, the detector strands of the nanoswitch will …

Immersive Extended Reality For Lower Limb Rehabilitation: Design, Deployment, And Pilot Study, Jeremy Varghese

Electronic Theses & Dissertations (2024 - present)

This thesis presents the design, deployment, and pilot study of an immersive extended-reality (XR) rehabilitation system integrated with a ceiling-mounted dynamic body-weight support device (Vector Gait and Safety System), aimed at improving lower-limb rehabilitation out- comes. The implemented system combined immersive virtual tasks—such as Touch Wall, Ball Launcher, Obstacle Dodge, and Stepping Stones—with real-time movement tracking, enabling detailed kinematic analysis and personalized therapy. A pilot study conducted at Sunnyview Rehabilitation Hospital involved seven patients with various mobility impairments, providing quantitative performance metrics and quali- tative user feedback. Results demonstrated consistent patient engagement, measurable im- provements in gait speed and task …

The Invisible Costs Of Privatizing Welfare: Administrative Burdens In Contracted Medicaid, Soyun Jeong

Electronic Theses & Dissertations (2024 - present)

Why do governments favor contracting out social services? Do private actors guarantee a better service experience for citizens? How should we understand the trade-off between efficiency and high-quality service delivery? These are the central questions that motivate this dissertation. Focusing on Medicaid, one of the largest social safety net programs in the United States, this dissertation investigates the impact of outsourcing Medicaid delivery to private health insurance companies. It explores how this privatized structure generates administrative burdens and shapes policy feedback effects. Theoretically, this project seeks to bridge the administrative burden and policy feedback literature by examining how burdensome policy …

Dna And Protein Determinants For P63 Transcriptional Activity, Abigail Mccann

Electronic Theses & Dissertations (2024 - present)

The transcription factor p63 is critical for development of the epidermis and other epithelial-related structures. Mutations in the DNA-binding domain of p63 lead to a range of human developmental disorders characterized by symptoms such as ectrodactyly, painful skin dysplasia, and cleft lip and palate. The TP63 gene is also amplified in squamous cell carcinomas, contributing to tumor pathogenesis. While the importance of p63 in human health is well established, the mechanisms underlying its control of an essential gene network remain unclear. TP63 encodes multiple isoforms with distinct N- and C-terminal domains. The ∆Np63α isoform is directly linked to epidermal development …

The Intermediate And Remote Effects Of Acute Juvenile Stress Upon Auditory Fear Learning, Recognition Memory, And Anxiety Measures In A Rodent Model Of Ptsd, Laura J. Baron

Electronic Theses & Dissertations (2024 - present)

Abstract

Early-life stress is a risk factor for increased susceptibility to stress- and trauma-related disorders, including Posttraumatic Stress Disorder (PTSD). PTSD is characterized by exposure to trauma that results in exaggerated and extinction-resistant fear responses that persist for over a month. Understanding how the severity of early-life stressors in animal models impacts adult behavior, cognition, and underlying neurobiology could aid in the development of more effective PTSD treatments.

Various early-life stress models, especially in infant rats, have been used to induce stress and assess PTSD like-symptoms. Different stressors impact short- and long-term behavior, with some effects influenced by developmental timing …

Grandparenthood And Psychological Well-Being Of Middle-Aged And Older Adults: Multigenerational Family Relationships In China, Dandan Zhao

Electronic Theses & Dissertations (2024 - present)

This dissertation examines whether and how experiences of grandparenthood—including becoming a grandparent, providing grandchild care, living with grandchildren, and exchanging intergenerational support—affect the well-being of middle-aged and older adults in China. Drawing on data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2018), a nationally representative survey of Chinese adults aged 45 and older, the study employs Ordinary Least Squares (OLS) regression and random effects models to investigate the associations between multigenerational family relationships and depressive symptoms among this population.

There is limited evidence that the transition to grandparenthood itself has a significant impact on psychological well-being. However, patterns …

Investigating Post-Adoption Abandonment Of Mental Health Mobile Applications Among Young Adults, Donald Harris

Electronic Theses & Dissertations (2024 - present)

The rising prevalence of mental health issues among young adults has driven increased interest in Mental Health Mobile Applications (MHMAs), which offer accessible and cost-effective solutions to traditional barriers such as financial limitations, stigma, and restricted healthcare access. Despite their promise, MHMAs frequently experience high rates of attrition and abandonment, significantly limiting their long-term effectiveness. Employing a mixed-methods, multi-stage research design, this dissertation explores the determinants of MHMA abandonment among young adults, emphasizing the interplay between technological inhibitors and enablers, individual user characteristics, and the mediating roles of user satisfaction and perceived usefulness.

Study 1 utilized quantitative text analysis, including …

Individual Participant Data Meta-Analysis Of Single-Case Experimental Design Data: A Comparison Of Bayesian And Restricted Maximum Likelihood Estimation, Yukang Xue

Electronic Theses & Dissertations (2024 - present)

Two-stage individual participant data (IPD) meta-analysis can be used to synthesize intervention effects from single-case experimental design (SCED) studies with multilevel modeling. However, various challenges exist at both stages, including standardizing the intervention effect size, accounting for autocorrelation, and estimating the between-study and between-case variances. While both restricted maximum likelihood estimation (REML) and Bayesian estimation can be used to estimate model parameters, REML has been more commonly applied despite the potential advantages offered by Bayesian methods. Moreover, no methodological studies have focused on Bayesian estimation in the context of meta-analysis of SCED studies, let alone when IPD meta-analysis (often recommended …

Personal Characteristics, Goal Setting, And Academic Thriving, Hedayat Ghazali

Electronic Theses & Dissertations (2024 - present)

Abstract

This dissertation examines if pre-existing personal characteristics influence the effectiveness of a reflective goal-setting intervention on credits completed among first-year university students. Grounded in goal-setting theory and self-regulated learning frameworks, the study investigates the roles of self-efficacy, intrinsic motivation, metacognitive strategies, and autonomy in shaping students’ academic outcomes. Using hierarchical cluster analysis, four distinct learner profiles were identified based on these personal characteristics. A two-way repeated measures ANOVA was conducted to evaluate whether the intervention significantly affected students’ academic performance—measured in credits completed —over three time points (T0, T1, T2) across intervention and control groups.

The results revealed a …

Analysis Of Extreme Rainfall And Streamflow Events In The Catskill/Delaware Catchment Using The New York State Mesonet, Ada Ellingworth

Electronic Theses & Dissertations (2024 - present)

Extreme rainfall and streamflow often lead to increased turbidity in reservoirs in the Catskill/Delaware catchment, which is part of the New York City water supply system. To better understand extreme events that lead to increased turbidity, this study takes a dual approach: first, we identify hydrologic conditions during extremes to understand when and why extremes occur. Next, we evaluate an identified extreme case to evaluate mesoscale model skill in this region. Measurements from the New York State Mesonet and United States Geological Survey are used to identify hydrologic conditions from 2017-2024 associated with three extreme event types: rainfall, streamflow, and …

Association Of Non-Communicable Diseases With Severe Covid-19 Among People Living With And Without Diagnosed Hiv/Aids In New York State, Ravi Kumar Balu

Electronic Theses & Dissertations (2024 - present)

Background: People living with diagnosed HIV (PLWDH) have a higher chance of co-infections and co-morbidities than the general population. When SARS-CoV-2 was first reported in China in December 2019 and later declared a pandemic, it was speculated that PLWDH might be more prone to SARS-CoV-2 infection and severe disease outcomes given their increased vulnerability to other respiratory infections like influenza, pneumococcal pneumonia and tuberculosis. However, several facets of COVID-19 disease in PLWDH are incompletely understood, including whether non-communicable diseases (NCDs) are strong risk factors for severe disease outcomes and death as they are in the general population.

Methods: The data …

Complex Missing Data Problems In Education Surveys, Thomas Wesley Robertson

Electronic Theses & Dissertations (2024 - present)

Missing data are a nearly universal problem in human subjects research, including in education. However, reporting and addressing missing data is an issue, despite guidelines from the APA style guide and the What Works Clearinghouse, as well as guidance from prominent statisticians on the best methods to use. Prior research conducted in 2004 and 2014 found that in the field of education, most studies do not report or address missing data. In addition, no study has looked specifically at how missing data are reported and addressed in complex surveys. The current study has two main objectives: first, to determine if …

Jedi Mind: Student And Teacher Perceptions Of Justice, Equity, Diversity, And Inclusion, Jessica W Coles Gray

Electronic Theses & Dissertations (2024 - present)

This study uses the Panorama Equity and Inclusion Survey as a measurement tool to examine the perceptions of equity and inclusion among teachers and students in a K-12 educational setting. Grounded in critical race theory, this research employs a QUANT-CRIT mixed methods approach to illuminate systemic inequities and amplify the voices of historically marginalized groups. A review of the existing literature reveals persistent disparities in educational experiences and outcomes for students and teachers of color, underscoring the need for a dual focus on both quantitative patterns and qualitative narratives. The study addressed two primary research questions: (1) What are teachers’ …

The Rights Of Nature Meaning-Making Experiments In Ecuador: A Pragmatist Inquiry, Lourdes Aguas Gonzalez

Electronic Theses & Dissertations (2024 - present)

Ecuador is the first and only country in the world to recognize nature as a subject of rights in its national Constitution, with the most court cases to date, and with a vibrant moral imagination regarding the more-than-human world. Building on the pragmatist tradition, my research examines three questions: What are the rights of nature in Ecuador? How is nature politically represented in Ecuadorian legal forums? And how can collective problem-solving experiments around the rights of nature in Ecuador inform moral inquiry? To answer these questions, I bring sociology in conversation with philosophy. My theoretical and methodological tools as a …

"Assessment Of The Likelihood To Stay Below 2 Degree Celsius Warming: Combining Modeling And Scenario Uncertainty.", Peter M. Booker

Electronic Theses & Dissertations (2024 - present)

ABSTRACT

Uncertainty in how much the Earth will warm in response to rising atmospheric CO₂ concentrations remains a major challenge for climate science and policy. In particular, estimates of equilibrium climate sensitivity (ECS) and transient climate response (TCR) directly affect projections of global mean surface temperature (GMST) and the allowable carbon budget for limiting warming to 2°C by 2100.

This study assesses the performance of a two-layer energy balance model (EBM) in reproducing TCR and ECS values under CMIP6 forcing scenarios, with a focus on SSP2-4.5. EBM outputs are compared against General Circulation Models (GCMs), and agreement is evaluated using …

The Psychological Impacts Of Homeland Havoc Among First-Generation Raised Americans: An Interpretive Phenomenological Analysis, Raneem Kurzum

Electronic Theses & Dissertations (2024 - present)

The current study explored the psychological experiences of first-generation raised U.S. citizens whose ancestral homelands are affected by ongoing or recent havoc. First-generation raised Americans are defined as the first-generation to be born in the U.S. or those who immigrated to the U.S. during infancy (less than two years of age). While research on trauma, resilience, and identity has previously addressed collective and intergenerational responses within culturally homogenous groups, few studies have examined the cross-cultural psychological impact of homeland turmoil among diverse diasporic populations living in the U.S.

Using Interpretive Phenomenological Analysis (IPA), this qualitative study employed semi-structured individual interviews …

The Role Of The Nasal Migratory Mass In Olfactory Bulb Formation And Fertility, Charisse Martin

Electronic Theses & Dissertations (2024 - present)

The olfactory migratory mass plays an essential role in the development of the olfactory bulb by facilitating the migration of the gonadotropin-releasing hormone neurons from the olfactory placode to the pre-optic hypothalamic area in the brain. In mammals, the migration of GnRH neurons is critical for establishing the hypothalamic-pituitary-gonadal axis (HPG axis), which regulates reproductive function through the production and secretion of gonadotropins. Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) instruct the gonads to function appropriately, ensuring sexual maturation and fertility. Disruptions in this migratory pathway have been linked with Kallmann syndrome, a condition characterized by low levels of GnRH, …

Food Rescue, Food Waste, And Policy In New York: A Mixed-Methods Study Of Food System Impacts, Mariana Torres Arroyo

Electronic Theses & Dissertations (2024 - present)

This dissertation investigates how food donation policies in New York State influence the recovery, redistribution, and waste of surplus fresh produce, with a focus on fruits and vegetables. Using an interdisciplinary, systems-based approach that integrates system dynamics modeling with qualitative, community-engaged research, the study analyzes the effectiveness and unintended consequences of three major policies: Nourish New York, the Farm to Food Bank tax credit, and the Food Donation and Food Scraps Recycling Law.

Chapter 2 uses simulation modeling to examine how the tax credit and waste ban affect produce recovery and redistribution. Results show that while both policies can boost …

Comparison Of Methane Emission Quantification Methods At Landfills In New York State, Alexandra M. Catena

Electronic Theses & Dissertations (2024 - present)

Greenhouse gas (GHG) emission increases are a consequence of global population rise and economic growth. It is well known that carbon dioxide is the dominant GHG by mass, but methane has received increasing attention recently due to its high warming potential and relatively short lifetime of about a decade. Methane has several different types of both natural and anthropogenic sources including wetlands, waste management, energy, agriculture and farming, and wildfires, which makes tracking and reducing methane emissions a complex problem. The emission rates of each of these sources are highly uncertain due to differing emission estimation methods, which can be …

Clinical Experiences In Conducting Empirically Supported Treatments For Insomnia, Sondra S. Tiab

Electronic Theses & Dissertations (2024 - present)

Controlled research shows that cognitive-behavioral therapy (CBT) is an effective treatment for insomnia, yet clinician experiences with applying CBT in routine settings has received limited attention. This study replicated and extended upon the Two-Way Bridge initiative (Goldfried et al., 2014), which aimed to establish a dialogue between researchers and clinicians on the identification of variables that promote and interfere with the effectiveness of evidence-based therapies. This survey study asked clinicians to identify variables they have encountered that make it challenging to implement CBT and related interventions for insomnia. N = 182 clinicians completed an online survey on typical assessment practices, …

Safeguard Cyberspace In Ransomware Era: Risk Analysis & Cyber Insurance, Li Huang

Electronic Theses & Dissertations (2024 - present)

The increasing frequency and severity of ransomware attacks pose significant challenges for organizational cybersecurity. Fragmentation across disciplines in cyber defense has created practical gaps in the development of the necessary capabilities needed to address rapidly evolving cyber threats. This study explores the impact of ransomware attacks and the evolving role of cyber insurance as a proactive cybersecurity partner. Bridging the gap between actuarial science and cyber risk management, it proposes an interdisciplinary framework that quantifies the impact of ransomware and integrates cyber insurance into cybersecurity strategies.

The primary contribution of this study is methodology. We present a framework that remains …

Street Outreach And Reentry: The Role Of Community Violence Intervention In The Reintegration Of Returning Citizens, Hilary Jackl

Electronic Theses & Dissertations (2024 - present)

Amidst ongoing efforts to reduce the nation’s prison population, as well as calls to defund the police and invest in civilianized public safety strategies following the murder of George Floyd, community-based violence intervention (CVI) strategies have been increasingly recognized as a critical means by which to ameliorate the United States’ enduring gun violence problem without exacerbating the harms of overpolicing and mass incarceration. However, most contemporary CVI research has assessed program impacts on neighborhood rates of gun violence and has produced conflicting findings, leading scholars to call for the need to examine a wider range of program-related functions and outcomes. …