Digital Commons Network^™

Oral Microbiome And Inflammatory Bowel Disease: New Understanding And Call To Action, Michael Saadeh, Sydney Donohue, Shaina Ailawadi, Gordon Hong, David A. Johnson

Department of Medicine Faculty Publications

The oral microbiome is the second largest microbial community in the human body after the gut microbiome. It includes an array of fungi, bacteria, amoebae, flagellates, archaea, and viruses, all of which are potential pathogens. This microbiome can act as a facilitator not only for protection but also for aggravation when dysbiosis occurs. Although conventional thought is this is primarily in terms of oral health issues, such as dental caries and gingival disease. The systemic effects of the oral microbiome however, are relevant to both gastrointestinal (GI) disease and non-GI disease. These systemic risks occur for several reasons, including upregulation …

The Urgent Need For Well-Being Programs In Medical Residencies In Brazil, Marcelo Bruno Generoso, Pedro Shiozawa, Ricardo Uchida, Marsal Sanches

Faculty, Staff and Student Publications

No abstract provided.

A Prior-Knowledge-Guided Feature Selection Method And Its Application To Biomarker Identification Of Schizophrenia, Ying Xing, Godfrey D Pearlson, Peter Kochunov, Vince D Calhoun, Yuhui Du

Faculty, Staff and Student Publications

Despite considerable efforts to uncover the neural basis of psychiatric disorders using neuroimaging, few methods utilize intrinsic brain-derived knowledge, leading to limited specificity and discriminability in biomarker identification. To leverage the inherent characteristics within the brain, we propose a prior-knowledge-guided feature selection method to flexibly unveil discriminative and target-oriented biomarkers of psychiatric disorders. Specifically, we construct a constrained sparse regularization allowing for the flexible integration of diverse prior knowledge to identify sparse neuroimaging features linked to specific psychopathology. Additionally, we simultaneously integrate graph-based regularization and redundancy-removal regularization to further ensure the discriminability and independence among the selected features. Different priors …

Brazilian Psychiatric Association Guidelines For The Treatment Of Social Anxiety Disorder, Leonardo Baldaçara, Thales Marcon Almeida, Diogo Cesar Dos Santos, Ana Beatriz Paschoal, Aldo Felipe Pinto, Luiz Antonio Vesco Gaiotto, Diogo De Lacerda Veiga, Fabiano Franca Loureiro, Leandro Fernandes Malloy-Diniz, Roseli Lage De Oliveira, Quirino Cordeiro, Marsal Sanches, Antônio E Nardi, Antônio Geraldo Da Silva, Ricardo R Uchida

Faculty, Staff and Student Publications

Social anxiety disorder (SAD), one of the most prevalent anxiety disorders, is not well recognized. In most cases, SAD follows an unremitted and chronic course, affecting individual functioning in relationships, education, and work. Due to the disorder’s relevance in Brazil, guideline-based treatments adapted to the Brazilian social and economic context are needed. We conducted a systematic review assessing several treatment modalities for SAD. PubMed, Cochrane, SciELO, and ClinicalTrials.gov were searched using the Medical Subject Headings social anxiety disorder and social phobia. Of the 438 selected articles, 20 were selected. Selective serotonin reuptake inhibitors are considered a first-line treatment for SAD …

Examining The Relationship Between Cardiometabolic Risk Factors And Telomere Length In Women: A Systematic Review, Jeni Page, Catherine Stephens, Melissa A Richard, Elizabeth Lyons, Elizabeth Baumler, M Terese Verklan, Elizabeth Lorenzo

Faculty, Staff and Student Publications

Background and objectives: Cardiometabolic syndrome (CMS) poses a significant public health challenge due to its rising prevalence in aging and significant healthcare costs. Recent studies have suggested telomere length (TL), a marker of cellular aging, may be impacted by CMS among women, but comprehensive evidence remains limited. This study aimed to examine the association between CMS risk factors (increased waist circumference [WC], elevated blood pressure, impaired fasting blood glucose, elevated triglycerides, decreased high-density lipoproteins) and TL in women, with consideration of age and race or ethnicity.

Research design and methods: A systematic review was conducted following PRISMA guidelines, with searches …

Mental Health Outcomes Of Latino Emerging Adults With Autism Spectrum Disorder In A Community-Based, Transition To Adulthood Program, Antonio F Pagán, Ana C Ramirez, Katherine A Loveland, Cecilia Montiel-Nava, Ron Acierno

Faculty, Staff and Student Publications

Latino individuals with autism spectrum disorder (ASD) face unique challenges during their transition to adulthood. This study evaluates ¡Iniciando! la Adultez, a culturally adapted behavioral health program aimed at addressing the co-occurring mental health needs of Latino young adults with ASD and their families. The program integrates culturally relevant elements to enhance engagement and effectiveness. Results indicated that the behavioral health intervention was associated with significant reductions in anxiety and depressive symptoms, highlighting the urgent need for tailored behavioral health services in this population. Additionally, the involvement of parents in group therapy demonstrated a positive impact on both parental and …

Consistent Frontal-Limbic-Occipital Connections In Distinguishing Treatment-Resistant And Non-Treatment-Resistant Schizophrenia, Yijie Zhang, Shuzhan Gao, Chuang Liang, Juan Bustillo, Peter Kochunov, Jessica A Turner, Vince D Calhoun, Lei Wu, Zening Fu, Rongtao Jiang, Daoqiang Zhang, Jing Jiang, Fan Wu, Ting Peng, Xijia Xu, Shile Qi

Faculty, Staff and Student Publications

Background and hypothesis: Treatment-resistant schizophrenia (TR-SZ) and non-treatment-resistant schizophrenia (NTR-SZ) lack specific biomarkers to distinguish from each other. This investigation aims to identify consistent dysfunctional brain connections with different atlases, multiple feature selection strategies, and several classifiers in distinguishing TR-SZ and NTR-SZ.

Study design: 55 TR-SZs, 239 NTR-SZs, and 87 healthy controls (HCs) were recruited from the Affiliated Brain Hospital of Nanjing Medical University. Resting-state functional connection (FC) matrices were constructed from automated anatomical labeling (AAL), Yeo-Networks (YEO) and Brainnetome (BNA) atlases. Two feature selection methods (Select From Model and Recursive Feature Elimination) and four classifiers (Adaptive Boost, Bernoulli Naïve …

Detection Of Erg11 Gene Mutation In Coding And Non-Coding Regions Of Clinical Candida Glabrata (Nakaseomyces Glabratus) Isolates From Pakistan, Saba Memon, Najia Karim Ghanchi, Urooj Zafar, Joveria Farooqi, Sadaf Zaka, Kauser Jabeen

Faculty, Staff and Student Publications

Azoles inhibit the cytochrome P450-dependent enzyme lanosterol 14α-demethylase (CYP51) that is encoded by the ERG11 gene. Azole resistance in Candida species arises through different mechanisms, like mutations in the ERG11 gene, ERG11 overexpression, CDR1,2 (Candida drug resistance) overexpression that actively efflux azole drugs, reducing their intracellular concentration and therapeutic effectiveness, and biofilm formation. We sequenced the ERG11 gene to determine mutations in the coding and non-coding regions of ERG11 in clinical isolates of Candida glabrata (Nakaseomyces glabratus) from Pakistan. Eight C. glabrata (N. glabratus) strains from our fungal strain bank (five fluconazole-resistant and …

Peer Support During In Vivo Exposure Homework Increases Likelihood Of Prolonged Exposure Therapy Completion, Melba A Hernandez-Tejada, Madeline J Bruce, Wendy Muzzy, Anna Birks, Giovanni Macedo E Cordeiro, Stephanie M Hart, Stephanie Hamski, Ron Acierno

Faculty, Staff and Student Publications

Exposure-based treatments such as prolonged exposure therapy (PE) are effective for veterans with PTSD. However, dropout rates as high as 50% are common. The Department of Veterans Affairs employs peers to increase mental health treatment engagement, however peers are not routinely used to help patients complete PE homework assignments. The present study included 109 veterans who decided to drop out from exposure-based treatment after completing seven or fewer sessions and used a randomized controlled design to compare PE treatment completion rates in response to 2 forms of peer support: (1) standard weekly telephone-based peer support vs. (2) peer-assisted in vivo …

Therapeutic Alliance In A Culturally Tailored Transition Program For Latino Young Adults With Autism And Their Families, Antonio F Pagán, Katherine A Loveland, Ron Acierno

Faculty, Staff and Student Publications

Latino young adults with autism spectrum disorder (ASD) often face barriers to accessing culturally appropriate interventions that support adaptive functioning and family dynamics. Therapeutic alliance, the collaborative and trusting relationship between participants and providers, is a critical component of intervention success, yet its role in culturally tailored programs for Latino families remains underexplored. The present study examined therapeutic alliance in ¡Iniciando! la Adultez, a 12-week, culturally adapted intervention for Latino young adults with ASD and their Spanish-speaking parents. The program integrates Latino cultural values and language and consists of parent group therapy, young adult group therapy, and individual therapy sessions. …

The Software Inducement Paradox, Dylan Niederland

American University Law Review

Induced patent infringement allows a third party to be held liable for another’s direct infringement of a patent. For many years, inducement liability has been a hotly contested doctrine of patent law, specifically its applications in the pharmaceutical industry. Not unsurprisingly, vast literature exists covering the intersection of inducement liability and pharmaceuticals.

This Note takes a new approach, analyzing inducement liability as it relates to the software industry. Specifically, this Note criticizes the Federal Circuit’s holding in GlaxoSmithKline LLC v. Teva Pharmaceuticals USA, Inc. that a simple statement of equivalence is sufficient to induce users to infringe method-of-use patents that …

Post-Stroke Lateropulsion In Australia And New Zealand: A Survey Investigating Current Knowledge, Priorities And Practice, Jessica Nolan, Angela Jacques, Barbara Singer

Research outputs 2022 to 2026

Background: Post-stroke lateropulsion is prevalent and associated with poor rehabilitation outcomes, but evidence to guide rehabilitation of affected stroke survivors is limited. Current post-stroke lateropulsion rehabilitation practice across Australia and New Zealand has not been previously described. Objectives: This study aimed to describe lateropulsion rehabilitation practice in Australia and New Zealand, determine clinicians,’ educators’ and researchers’ opinions about the need for educational resources to guide best-practice, and to identify current barriers to, and enablers of, optimal rehabilitation delivery. Methods: This cross-sectional survey was distributed to stroke rehabilitation clinicians, educators and researchers across Australia and New Zealand using Qualtrics. Data were …

Flexural Post-Cracking Performance Of Macro Synthetic Fiber Reinforced Super Workable Concrete Influenced By Shrinkage-Reducing Admixture, Jingjie Wei, Nima Farzadnia, Kamal H. Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Most literature has focused on the effect of shrinkage-reducing admixture (SRA) in shrinkage mitigation resistance of concrete. This study aims to examine the impact of SRA on the efficiency of macro synthetic fibers (MSF) in enhancing the flexural post-cracking behavior of fiber-reinforced super workable concrete (FR-SWC). A comparative analysis of the influence of fiber combinations on the flexural post-cracking behavior of beams is also included. Results showed that a higher dosage of SRA, particularly at 5 % by mass of binder, had a noticeable negative impact on flexural post-cracking performance of beams while exhibiting positive effect on workability and shrinkage …

Guest Editorial, Li Ai, Xiao Tan, Arslan Akbar, Guirong Yan

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.

Quantifying Deviation Of Elasticity In The Quasi-Elastic Domain Of Granular Soils, Wen Deng, Yufan Jin, Pingxin Xia, Qingqing Fu, Xiong Xia, Xiaoxia Guo

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The absence of purely elastic properties in granular soil is attributed to the reversible sliding that occurs between particles during the loading–unloading cycle, leading to the dissipation of energy through friction. Instead of the strictly elastic domain, we opt for a quasi-elastic domain to examine elastic behavior within the confines of elastic theory. Within this quasi-elastic realm, the response deviates to some extent from the idealized pure elastic behavior posited by the elastic theory. As a result, the elastic constitutive relations applied to granular materials are no longer strictly accurate and may exhibit deviations. With the aim of exploring the …

Innovative Air Convection Embankment For Cold/Arctic Region Low-Volume Roads, Hanli Wu, Jenny Liu, Xiong Zhang, Steve Saboundjian

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Roadbed thaw settlement is a unique challenge for the durability of low-volume roads (LVRs) in permafrost regions. Air convection embankment (ACE) is an effective technique that acts as a semi-heat-transfer system to control temperature variation and reduce the thaw depth of subsoil. However, limited by the shortage of the necessary crushed rocks within a short distance, building an ACE in Alaska, U.S., is prohibitively expensive. Previous studies identified the feasibility of using cellular concrete for ACE and determined the optimized thickness of the cellular concrete aggregate interlayer for ACE. However, the economic efficiency and thermal and mechanical performance of the …

Performance-Based Approach To Characterize External Sulfate Attack For Reactive Powder Concrete, Umut Bakhbergen, Chang Seon Shon, Dichuan Zhang, Jong Ryeol Kim, Jenny Liu

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Reactive powder concrete (RPC) is a relatively new type of high-performance concrete, offering enhanced load-bearing capacity, mechanical strength, and durability. The enhanced microstructural density of RPC with the incorporation of reinforcing fibers significantly increases its resistance to durability challenges, particularly against external sulfate attack (ESA). However, conventional laboratory testing methods for evaluating the resistance of RPC to ESA are limited. Hence, a new performance-based approach was developed to evaluate the durability of RPC exposed to ESA. Expansion of nine RPC mixtures designed by Taguchi L9 orthogonal array method with four factors (steel fiber content, water-to-binder ratio (w/b), silica fume content, …

Mars Sample Return Earth Entry System Uncertainty Analysis, Michael D. Squire, Victor Cabrera, Eric Christiansen, Alan Jenkin, Kevin Hoffman, Quincy Mckown, Peter Parker, Glenn Peterson, Bruno Victorino Sarli, William P. Schonberg, Katie Steward, Brian Tulaba, Joel Williamsen

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Spacecraft designers and operators use micrometeoroid and orbital debris (MMOD) risk assessments to predict the probability that an MMOD particle impact will cause a critical failure to their systems. An important aspect of MMOD risk and associated requirements is the treatment of uncertainty, often difficult to quantify, or even estimate, for many elements of MMOD risk. This paper describes recent efforts to estimate uncertainties in inputs to the MMOD risk assessment process for a portion of the planned Mars Sample Return (MSR) campaign. The uncertainty bounds developed were used to examine their effect on overall mission MMOD risk.

Extending The Applicability Of Thermal Protection System Ballistic Limit Equations Beyond The Testable Regime, William P. Schonberg, Michael D. Squire

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Spacecraft use thermal insulation in their design, which is usually placed on their exterior. As such, it is susceptible to high-speed impacts by meteoroids and orbital debris, which can damage it to a point where the protection it offers is below acceptable limits. It is important to be able to characterize expected levels of damage stemming from such high-speed impacts. In this paper, we extend the applicability of a previously developed ballistic limit equation (BLE) for one such thermal insulation material using the results of a series of Smooth Particle Hydrodynamics Code (SPHC) impact simulations at velocities in excess of …

Identifying Early Warning Signs Of Construction Labor Shortages, Ahmed Shiha, Islam H. El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Construction labor shortages constrain project-level objectives and national development plans. The goal of this study is to utilize the lagged effects of macroeconomic conditions as early warning signs of construction labor shortages. To this end, the authors adopted a methodology, encompassing (1) retrieval of publicly available data and preprocessing of construction labor shortage as the target variable and macroeconomic measures as the explanatory variables, (2) identification of short-term associations between shortages and economic cycles using the Granger causality test, (3) examination of long-term relationships between labor shortages and economic conditions using the Johansen cointegration test, and (4) estimation of the …

Reevaluating The Van’T Hoff And Arrhenius Equations: How Temperature And Pressure Affect Chemical Reaction Thermodynamics, Equilibrium, And Kinetics, Jianmin Wang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The van’t Hoff equation, which is used to calculate the effect of temperature on equilibrium constants, was derived from the Gibbs – Helmholtz equation that relates the molar Gibbs free energy to the molar enthalpy of a chemical reaction. However, the Gibbs – Helmholtz equation was developed for systems that do not consider contributions of Gibbs free energy from chemical species. Consequently, the van’t Hoff equation and the Arrhenius equation derived from it are technically incomplete.

By employing Hess’s law and the appropriate Gibbs free energy equation for chemical reaction systems, this investigation develops theoretical equations to calculate the effects …

Material Suppliers’ Perspective On Collaboration In Industrial Construction Projects, Seogjae Choi, William J. O'Brien

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Material suppliers' involvement in construction project planning has been recommended as an effective measure to improve project performance by using their expertise. However, the recommendation is not universal, and some researchers disputed the value of early involvement of suppliers depending on material type. Moreover, prior studies considered main contractors' and owners' perspectives mostly in examining how to increase the involvement of suppliers. To add material suppliers' perspective, this study conducted interviews with experienced professionals from 16 material suppliers including standardized, make-to-order, and custom products. The results are specified by separating the type of materials and sub-phases of planning. The results …

Polarimetry Based Radar Estimation Of Extreme Rainfall: Case Studies, Bong Chul Seo, Witold F. Krajewski, James A. Smith

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The study evaluated radar-derived polarimetric rainfall estimates for extreme rain events that occurred in the Kansas City Metropolitan area in the United States. To derive quantitative precipitation estimates (QPE), we implemented two polarimetric algorithms based on specific attenuation (A) and specific differential phase (KDP), along with the reflectivity (Z) based one using data from two radars in the study area. The analysis to assess radar-rainfall estimates (R) utilizes ground observations from a dense network of about 170 rain gauges. Based on our analysis results, the two polarimetric estimates from R(A) and R(KDP) outperform the conventional estimation R(Z). R(A) appeared to …

Effect Of Gluconate Molecules On The Reaction Kinetics Of C-(N)-A-S-H And N-A-S-H Gel Formation, Jiafeng Kong, Chao Sun, Zuhua Zhang, Chenglong Cai, Yubin Cao, Yanru Wang, Hongyan Ma, Xuesen Zeng, Hao Wang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Organic ligands are widely used to regulate setting in cementitious binders, yet their chemistry-selective action in geopolymers (GPs) remains unclear. Here we isolate the role of sodium gluconate (SG) in early reaction kinetics across a Ca-rich GP that forms a calcium-(sodium)-aluminosilicate hydrate (C-(N)-A-S-H) gel and a Ca-poor GP that forms a sodium-aluminosilicate hydrate (N-A-S-H) gel. Four GPs spanning Ca/Si ≈ 1.01 to 0.01 were prepared with identical activator chemistry and dosages of SG up to 5 wt.% of precursors. Setting time, isothermal calorimetry, pore-solution speciation (TOC, ICP-OES, and pH), selective dissolution (reaction extent), low-field¹H NMR, XRD, FTIR, SEM-EDS, …

Every Publication Needs An Author Verified Tl;Dr Statement, Sarah Oerther, Daniel B. Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.

Characterizing Heat Transfer Performance In A Slurry Bubble Column Reactor Equipped With A Real Heat Exchanger, Dalia S. Makki, Hasan Sh Majdi, Amer A. Abdulrahman, Abbas J. Sultan, Bashar J. Kadhim, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Abstract: This study examines the impact of equipping a real heat exchanger in a slurry bubble column SBC on instantaneous and local heat transfer coefficients IHTC and LHTC, as well as the overall heat transfer coefficient U, employing advanced heat transfer techniques. The experiments were conducted in a 0.15 m inner diameter Plexiglas SBC with varying gas flowrates Ug (0.14–0.35) m/s at several radial sites along the column's diameter (±0.18, ±0.46, and ± 0.74) and three axial locations (H/D = 2, 3 and 4). To simulate the industrial Fischer–Tropsch bubble column reactor FT-BCR, a real heat exchanger consisting of 18 …

Mechanistic Scale-Up Of Gas-Solid Fluidized Beds Via Local Hydrodynamic Similarity, Faraj M. Zaid, Thaar M. Aljuwaya, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

This study presents a detailed experimental evaluation of a newly developed mechanistic scale-up methodology for gas-solid fluidized beds. Traditional scale-up approaches typically rely on matching global dimensionless groups, which often fail to ensure local hydrodynamic similarity. In contrast, the new mechanistic method aims to achieve scale-up by matching the radial profiles of gas holdup between geometrically similar beds at corresponding dimensionless axial positions (z/D_c). This approach is based on the premise that when gas holdup profiles align, other key hydrodynamic parameters—such as solids holdup and particle velocity—also become similar. To validate this methodology, experiments were conducted in two …

Nonlinear Control Of Buck-Type Converters For Micro-Wind Generators, Noah Wilding, Shuzan Kumar Sarkar, Shruti Pandey, Michael L. Mcintyre

Electrical and Computer Engineering Faculty Research & Creative Works

Small-scale wind turbines offer a promising solution for distributed renewable energy generation. However, this approach often leads to wasted energy when battery capacity is reached, as excess energy is typically dissipated into resistors. The reliance on batteries further increases the cost and complexity of such systems. This paper presents a nonlinear control algorithm for regulating buck-type converters, providing a more efficient energy management solution. By employing a grid-connected inverter, excess energy is utilized rather than dissipated, potentially eliminating the need for batteries and reducing micro-wind turbine installation costs. The proposed control strategy manages the DC-link voltage for the inverter by …

Filter Based Motor Control For Robotic Applications, Shuzan Kumar Sarkar, Noah Wilding, Shruti Pandey, Nicholas Hawkins, Michael L. Mcintyre

Electrical and Computer Engineering Faculty Research & Creative Works

Controlling coreless DC motor in the field of humanoid robotic application involves considering various surrounding electromagnetic environment interference and sudden change of load with parameters variation of motor dynamics which makes the system complex. This paper presents a filter-based control scheme for a coreless DC motor drive system using an H-bridge inverter as the input circuit of the motor which is easy to implement and cost effective. From the electromagnetic characteristics, the dynamic model of the motor along with the control scheme is implemented in the commercial software PLECS. Then the effectiveness of this approach is validated through simulations demonstrating …

Ibis Model Simulation Accuracy Improvement With Slew Rate Correction, Yifan Ding, Chulsoon Hwang

Electrical and Computer Engineering Faculty Research & Creative Works

The accuracy of Power-Supply-Induced Jitter (PSIJ) simulation in Input/Output Buffer Information Specification (IBIS) models is critical for ensuring robust high-speed signal integrity analysis, but it lacks accuracy in predicting the PSIJ when the pre-driver exists in the model. Previous studies have proposed methods to improve IBIS PSIJ simulation accuracy with pre-driver effect included in the IBIS switching coefficients modification process. However, these methods fail to accurately model the output waveform slew rate change with varied power noise. In this work, an improved modification method was proposed to incorporate power-aware characteristics into the modified IBIS model, thereby improving the accuracy of …