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Articles 3601 - 3630 of 42613
Full-Text Articles in Entire DC Network
Educational Policy, Implementation, And Challenges: A Case Study Of Administrative Practice In Using Student Growth Measures For Instructional Improvement In A K-12 School District In Northern New Jersey, Dean Robinson
Theses and Dissertations
This qualitative single holistic case study explores how school administrators in a Northern New Jersey district implement student growth measures (SGMs) mandated by the New Jersey Department of Education. Grounded in Lipsky’s (1980) theory of street-level bureaucracy, Wright’s Connected Actions Roadmap (2022), and Argyris and Schön’s (1978) theory of action, this work examines how administrators in the case study navigate policy mandates while addressing the demands of leading their schools. Data was collected through two rounds of semi-structured interviews with eleven administrators, supplemented by field notes. Thematic analysis revealed five areas: administrative agency in balancing compliance and authenticity, collaboration as …
Housing Market Responses To Constrained Mobility Rights - Evidence From A School Enrollment Reform For Migrant Children, Yilin Hou, Jinghua Qi, Yugang Tang
Housing Market Responses To Constrained Mobility Rights - Evidence From A School Enrollment Reform For Migrant Children, Yilin Hou, Jinghua Qi, Yugang Tang
Center for Policy Research
Mobility matches open housing markets. With constrained mobility and partially open housing markets, market responses reflect the constraints. We study this mechanism by examining disparity in access to public schools across socio-economic groups, focusing on properties near primary schools accessible to migrant students under social integration policies in a Chinese megacity. Using a difference-in-differences approach, we uncover complex spatial and market dynamics: while house prices close to ordinary primary schools remained relatively stable, house prices farther away declined markedly. This differential impact suggests the interaction between a potential "peer effect" and an "amenity effect." The rental rates showed little change …
Fee Multipliers In Class Actions, Andrew J. Trask
Fee Multipliers In Class Actions, Andrew J. Trask
Louisiana Law Review
No abstract provided.
Neutrophil Lymphocyte Ratio As A Marker Of Skin Disease Activity In Older Children With Juvenile Dermatomyositis, Shreya Swaminathan, Nidhi Naik, Susan Shenoi, Sarah Vandenbergen, Jessica L. Turnier, Zilan Zheng, Jessica Neely, James S. Andrews, Christian Lood
Neutrophil Lymphocyte Ratio As A Marker Of Skin Disease Activity In Older Children With Juvenile Dermatomyositis, Shreya Swaminathan, Nidhi Naik, Susan Shenoi, Sarah Vandenbergen, Jessica L. Turnier, Zilan Zheng, Jessica Neely, James S. Andrews, Christian Lood
Student Papers, Posters & Projects
BACKGROUND: Neutrophils contribute to the pathogenesis of many autoimmune diseases. While the neutrophil to lymphocyte ratio (NLR) is associated with disease activity in adult dermatomyositis, its clinical utility in juvenile dermatomyositis (JDM) is unknown.
METHODS: Demographic, medication use, autoantibody profile, disease activity markers, and laboratory data from 97 JDM patients was collected using retrospective chart review. Patients were age-stratified (0–9 vs. 9–21 years of age), as white blood cell count stabilizes at 9 years. The relationships between NLR with JDM disease activity measures were analyzed using spearman’s correlation.
RESULTS: Patients were primarily white (56.7%) and female (71.1%). Older children had …
Bladder Prolapse (Cystocele) Among African, Asian, And Middle Eastern Women: A Clinical And Socio-Cultural Perspective, Gayathri Delanerolle, Vindya Pathiraja, Tharanga Mudalige, Nirmala Rathnayake, Abirame Sivakumar, Wijamunige Nimesha Prashadini, Nihal Mohamed Al Riyami, Lamiya Al-Kharusi, Mohammad Haddadi, Fred Tweneboah-Koduah, Om Kurmi, George Uchenna Eleje, Peter Phiri, Lauri Romanzi, Sohier Elneil
Bladder Prolapse (Cystocele) Among African, Asian, And Middle Eastern Women: A Clinical And Socio-Cultural Perspective, Gayathri Delanerolle, Vindya Pathiraja, Tharanga Mudalige, Nirmala Rathnayake, Abirame Sivakumar, Wijamunige Nimesha Prashadini, Nihal Mohamed Al Riyami, Lamiya Al-Kharusi, Mohammad Haddadi, Fred Tweneboah-Koduah, Om Kurmi, George Uchenna Eleje, Peter Phiri, Lauri Romanzi, Sohier Elneil
Department of Obstetrics and Gynecology Faculty Papers
Bladder prolapse, also known as cystocoele, is the most common form of pelvic organ prolapse (POP), significantly affecting women's physical, sexual, and psychosocial health, particularly in low- and middle-income countries (LMICs). Despite its widespread prevalence and disabling consequences, bladder prolapse remains under-recognised and inadequately addressed in global health strategies. Prevalence estimates vary widely across regions, from 3%-64.6%, influenced by diagnostic methods and cultural reporting biases. Common risk factors include high parity, early childbirth, prolonged labour, poor postpartum care, malnutrition, obesity, and ageing. Clinical diagnosis often relies on simplified grading systems in resource-limited settings. Conservative treatments like pelvic floor muscle training …
Newsletter 2025.11.24, Fcrh Honors Program
Newsletter 2025.11.24, Fcrh Honors Program
What's Going On, Honors? (2025-26)
No abstract provided.
Adolescent Girls’ Uptake Of Prep In Sub-Saharan Africa: A Meta-Aggregation Of Mixed Methods Studies, Susanna Aba Abraham, Dorcas Frempomaa Agyare, Benjamin Kofi Anumel, Mustapha Amoadu
Adolescent Girls’ Uptake Of Prep In Sub-Saharan Africa: A Meta-Aggregation Of Mixed Methods Studies, Susanna Aba Abraham, Dorcas Frempomaa Agyare, Benjamin Kofi Anumel, Mustapha Amoadu
Biennial Convention (CONV)
Background: Sub-Saharan Africa (SSA) is home to 25.9 million people living with HIV, with adolescent girls accounting for 63% of new infections [1,2]. These girls face risks compounded by gender-based violence, and limited sexual education [3]. Pre-exposure Prophylaxis (PrEP), estimated to be 99% effective in preventing HIV from intercourse and 77% from injectable drug use, is a promising prevention strategy [4]. Despite its efficacy, PrEP uptake and adherence among adolescent girls in SSA remain low [3]. This meta-aggregative review synthesizes evidence on PrEP uptake, adherence, facilitators, and barriers among adolescent girls, addressing a critical gap in research.
Methods: …
Design And Refinement Of Cybercelltm, A Virtual Reality Health Education Program For Adolescents And Young Adults With Sickle Cell Disease, Aimee Hildenbrand, Melanie Pitone, Benjamin Bear, Corinna L. Schultz, Sherman Finch, Danielle Morley, Stephanie Hubbard, Alyssa Decino, Melissa A. Alderfer, Lori E. Crosby, Fredric Freeman
Design And Refinement Of Cybercelltm, A Virtual Reality Health Education Program For Adolescents And Young Adults With Sickle Cell Disease, Aimee Hildenbrand, Melanie Pitone, Benjamin Bear, Corinna L. Schultz, Sherman Finch, Danielle Morley, Stephanie Hubbard, Alyssa Decino, Melissa A. Alderfer, Lori E. Crosby, Fredric Freeman
Department of Pediatrics Faculty Papers
For people living with sickle cell disease (SCD), the risk for disease complications and premature death rises sharply in adolescence and young adulthood, when chronic organ damage is compounded by reduced preventive care. To make informed health care decisions, adolescents and young adults (AYAs) require effective education about their health condition and treatment options. We aimed to systematically design and develop a user-centered, evidence-based virtual reality (VR) health education program to optimize the use of SCD therapies among AYAs with SCD. We engaged a diverse team including AYAs with SCD and their caregivers, multidisciplinary SCD clinicians and researchers, patient education …
Guiding The Story World: A Comparison Of Diegetic Cues In A Snow White Vr Narrative Game, Jiayi Xu
Guiding The Story World: A Comparison Of Diegetic Cues In A Snow White Vr Narrative Game, Jiayi Xu
Dartmouth College Master’s Theses
Virtual reality (VR) narrative games must guide players through complex story worlds without undermining immersion, yet prior work rarely compares different forms of in-world guidance under tightly controlled conditions. Designers routinely mix diegetic text, character behavior, and environmental motion, but it remains unclear how these cue families differentially shape cognitive load, task performance, and narrative experience when they convey the same instruction.
This thesis investigates how three common diegetic cue types—diegetic text, non-verbal gestures from a non-player character, and environmental motion and highlights—affect players in a first-person VR retelling of the Snow White story. In a between-subjects laboratory study, each …
Study On The Mechanical Characteristics Of A Natural Fiber-Based Hybrid Polymer Composite, Sanjay Dharmaraju, Sureshkumar Periyasamy, Murugesan Palaniappan, Dawit Tafesse Gebreyohannes
Study On The Mechanical Characteristics Of A Natural Fiber-Based Hybrid Polymer Composite, Sanjay Dharmaraju, Sureshkumar Periyasamy, Murugesan Palaniappan, Dawit Tafesse Gebreyohannes
Faculty, Staff and Students Publications
In this work, the hybrid fiber-based epoxy composite samples have been prepared with the application of three unlike organic natural fibers viz., Sisal (S), Ramie (R), and Flax (F) and epoxy as the matrix, with a weight ratio of 70:30 for epoxy and fibers. Six different stacking sequences of fibers, pure fibers and pure matrix were used for specimen preparation, namely S/F/F/F/S, F/S/S/S/F, F/R/R/R/F, R/F/F/F/R, R/S/S/S/R, S/R/R/R/S, PS, PR, PF, and Pure matrix. The composite specimen was prepared by manually and uniform thickness was obtained by the compression moulding process. The mechanical trials such as, tensile, impact, hardness, and flexural …
A Contemporary Review On Heart Failure With Improved Ejection Fraction, Lingling Wu, Mario Rodriguez, Muzamil Khawaja, Errol Moras, Carl J Lavie, Gregg C Fonarow, W H Wilson Tang, Biykem Bozkurt, Chayakrit Krittanawong
A Contemporary Review On Heart Failure With Improved Ejection Fraction, Lingling Wu, Mario Rodriguez, Muzamil Khawaja, Errol Moras, Carl J Lavie, Gregg C Fonarow, W H Wilson Tang, Biykem Bozkurt, Chayakrit Krittanawong
Faculty, Staff and Students Publications
Heart failure is a complex condition caused by various etiologies that reduce cardiac output or increase cardiac pressures. It is classified by left ventricular ejection fraction, a key prognostic factor. New therapies, devices, and better management of secondary causes have improved outcomes. A recently identified group-those with heart failure and improved ejection fraction-shows better prognosis. This review explores its definition, causes, clinical significance, and management strategies.
Markey Holds Slim Lead Over Moulton In Massachusetts Senate Dem Primary 11/24/2025, Unh Survey Center
Markey Holds Slim Lead Over Moulton In Massachusetts Senate Dem Primary 11/24/2025, Unh Survey Center
All UNH Survey Center Polls
Incumbent Democratic Senator Ed Markey holds only a small lead over Representative Seth Moulton in the race for the Democratic nomination for U.S. Senate in 2026. Potential candidates who have not officially announced their candidacy, Boston Mayor Michelle Wu and Representative Ayanna Pressley, are very popular among likely primary voters. State residents are divided on a proposal to allow people to buy and consume marijuana in the same space if the vendor has a special license while they support a ban on tests for marijuana use as a condition for employment. Housing and the cost of living are cited most …
Rhode Island Democratic Gubernatorial Primary Muddied By High Number Of Undecided Likely Voters 11/24/2025, Unh Survey Center
Rhode Island Democratic Gubernatorial Primary Muddied By High Number Of Undecided Likely Voters 11/24/2025, Unh Survey Center
All UNH Survey Center Polls
The 2026 Democratic primary for governor of Rhode Island remains unclear, as a plurality of likely voters are undecided on their choice of candidate. Helena Foulkes currently holds a slight lead over prospective candidate and Speaker of the RI House Joe Shekarchi and incumbent Governor Dan McKee. McKee is very unpopular among likely Democratic primary voters and suffers from low job approval among Rhode Islanders overall. Rhode Islanders would like state officials to intervene to keep Our Lady of Fatima and Roger Williams Medical Center open, with many state residents reporting they or their family used one or both hospitals. …
Some Like It Hot -Structural Changes In Extremophile Rubredoxin At 120 °C., Tzanko Doukov, Igor Leontyev, Francis E. Jenney, Dominic George, Stephen P Cramer
Some Like It Hot -Structural Changes In Extremophile Rubredoxin At 120 °C., Tzanko Doukov, Igor Leontyev, Francis E. Jenney, Dominic George, Stephen P Cramer
PCOM Scholarly Works
How does the structure of a protein change as the temperature is raised from cryogenic conditions at 100 K to 393 K? Understanding the structure and dynamics of proteins under environmental extremes is relevant for human health, biotechnological applications, and our search for life elsewhere in the universe. Here we reveal the high temperature crystal structure of a hyperthermophilic (Pyrococcus furiosus) rubredoxin at 393 K (120 °C), together with multiple complementary structures down to 100 K. The results are compared with molecular dynamics calculations. Significant changes in H-bonding are observed. Discussions about high-temperature protein structure and stability need to recognize …
Next Word Prediction In Social Media Texts For Punjabi-English Bilingual Users With Sequential Cnn-Bilstm, Gurpreet Singh, C P Kamboj
Next Word Prediction In Social Media Texts For Punjabi-English Bilingual Users With Sequential Cnn-Bilstm, Gurpreet Singh, C P Kamboj
Baghdad Science Journal
Preparing a collection of Punjabi-English social media text and creating a next word prediction system for Punjabi users are the main goals of this study. As the Gurmukhi script has a large character set, typing in Punjabi takes a lot of time. That is the reason behind using the Roman script for communication on social media platforms like WhatsApp, Facebook, and Twitter by many Punjabi users. For such users, we have proposed a sequential CNN-BiLSTM architecture to provide suggestions to improve typing speed and make communication convenient. In our proposed model, we used 128 filters and a kernel size of …
Designing Culturally Responsive Classrooms: Breaking Boundaries Using Bilingual Children’S Literature, Maryann Huebner
Designing Culturally Responsive Classrooms: Breaking Boundaries Using Bilingual Children’S Literature, Maryann Huebner
Honors Projects
The purpose of this study was to educate and empower teachers to implement culturally responsive teaching practices in the elementary classroom to create inclusive learning environments. With an emphasis on high-quality instruction and meaningful materials, the research aimed to support equitable learning opportunities for all students. The study had a specific focus on how the use of bilingual, culturally relevant children’s literature can be a powerful resource for developing bilingual abilities in students, enabling them to meaningfully and confidently participate in the multicultural classroom. To explore how children’s literature can foster bilingualism and biculturalism in students, I collected daily, reflective …
More Than A Monolith: Parental College Aspirations, Adolescents’ College Expectations, And Postsecondary Enrollment Among Asian Adolescent Immigrants, Rian R. Djita
Education Reform Faculty and Graduate Students Publications
Studies that are centered around social mobility and educational attainment have shown that educational aspirations and expectations play a critical role in an individual's future success. However, there are only a few analyses that focused on ethnic minorities or immigrants, particularly among Asian populations. These few studies about Asian American families tend to "lump" Asian immigrants as a monolithic ethnic group. This study seeks to bridge this gap by understanding different educational aspirations among immigrant parents from various Asian subgroups concerning their children's postsecondary enrollment in the U.S. Utilizing the High School Longitudinal Study of 2009 (HSLS:09), a nationally representative …
Improving Confidence And Competence In Treating Pediatric Peripheral Intravenous (Piv) Extravasation, Ann Gosdin, Hector Murillo, Taffi Marchand, Brook Warren
Improving Confidence And Competence In Treating Pediatric Peripheral Intravenous (Piv) Extravasation, Ann Gosdin, Hector Murillo, Taffi Marchand, Brook Warren
2025
EBP
Literature Review: Targeted nursing education has demonstrated it may lead to improved nursing care and patient safety. Nurses who received high-fidelity simulation and targeted traditional education on extravasation treatment had higher competency scores than those who did not received this education. Specific nursing education classes have demonstrated statistically significant improvement on nurses' knowledge, practice and minimized patients' complications of extravasations.
PICO: In hospitalized pediatric patients can additional education and training by the Vascular Access Team (VAT) for Peripheral IV Infiltration and Extravasation (PIVIE) on extravasation treatment increase knowledge, confidence, and competence in providing the appropriate treatment and increase the …
Epilogue: Postoperative 30-Day Follow-Up, Tess Davis, Karisa Price, Courtney Russ
Epilogue: Postoperative 30-Day Follow-Up, Tess Davis, Karisa Price, Courtney Russ
2025
INNOVATION & LEADERSHIP
Background: The NSQIP-P Surgical Clinical Reviewers (SCR) of Children’s Health of Texas initiated a quality project with the goal of maintaining an 80% postoperative follow-up rate. To remain relevant in the ever-changing landscape of healthcare, we recognize the need for thoughtful and individualized approaches to follow-up. Unprecedented growth in the healthcare sector creates a demand for innovative solutions to address the ever-changing needs of the pediatric surgical population. Patient expectations have driven the desire for organizational transparency and robust approaches to ensure optimal, holistic outcomes. This has been accomplished using tailored follow-up strategies to meet organizational …
Ask Me 3® In Action: Advancing Health Literacy In Pediatric Acute Care, Yaseming Medina
Ask Me 3® In Action: Advancing Health Literacy In Pediatric Acute Care, Yaseming Medina
2025
EBP
Literature Review: Parents and caregivers’ understanding of how to provide safe and effective care at home is vital. However, elevated levels of stress and limited health literacy face significant challenges in understanding discharge instructions. Patients who understand heath instructions make fewer mistakes when they take their medicine, follow treatment plans, and prepare for medical appointments. Patients have reported higher satisfaction and found that the use of Ask Me 3 was helpful in learning more about their medical condition.
PICO: For parents of pediatric patients seen in an acute perioperative setting, how will the use of the Ask Me 3 …
Saussure’S Universal Distinctive Feature Dimensions, Thomas M. Eccardt
Saussure’S Universal Distinctive Feature Dimensions, Thomas M. Eccardt
Publications and Research
This paper revisits Saussure’s scalar analysis of phonemes, offering a modern reinterpretation that replaces binary features with phonological dimensions grounded in measurement theory. By redefining Saussure’s [openness] and [backness] as ordered scales and Chomsky and Halle’s “combination and concatenation” as partially ordered scales, the paper introduces a notion of “[phono]logical simultaneity.” This framework renders the variously-defined phoneme and segment redundant, and shifts the focus of distinctiveness to the linguistic sign, the morpheme. It demonstrates how phonological dimensions link continuous articulations and acoustic signals (e.g., F1 and F2) with discrete linguistic signs through calibrated distinctive features. The analysis identifies Saussure’s two …
Cultural Synthesis In Iranian Graphic Design: A Fusion Of Tradition And Modernity, Maryam Mehrabadi
Cultural Synthesis In Iranian Graphic Design: A Fusion Of Tradition And Modernity, Maryam Mehrabadi
LSU Doctoral Dissertations
This thesis examines Iranian graphic design as a politically embedded and semiotically charged field wherein visual form operates as a site of ideological negotiation, cultural memory, and symbolic resistance. Focusing on the works of Ghobad Shiva and Morteza Momayez, the study situates graphic design within the sociopolitical constraints of the Pahlavi monarchy and the post-1979 Islamic Republic. It argues that Iranian design practices cannot be understood outside the country’s enduring identity crisis—shaped by the unresolved tension between three coexisting cultural strata: ancient Persian heritage, Islamic civilizational identity, and Western modernity. Drawing on the work of Edward Said, the thesis also …
Black On Black Sounds: Music, Migration, And The ‘Nu-K Blak’ Identity Formation In Early 21st Century Britain, Monique Charles
Black On Black Sounds: Music, Migration, And The ‘Nu-K Blak’ Identity Formation In Early 21st Century Britain, Monique Charles
Sociology Faculty Articles and Research
Examining literature on the under researched areas of Afrobeats and African migration to Britain, this article identifies significant internal shifts in the ethnic diversity of Black Britain —i.e., from Caribbean (predominantly Jamaican) to West African (Nigerian, Ghanaian) (ONS 2011). Interpreting literature and applying to the British context, it highlights how Afrobeats reshapes Blackness in Britain, particularly the incorporation of desirable Africanness through Afrobeats music. It argues that demographic and musical shifts in Britain result in a renegotiation of the Caribbean and US dominant 20th century Black Britishness — ‘UK Blak’ identity (as identified by Bradley 2013, Gilroy 1993 & Palmer …
Mycobacterium Chelonae Outbreak Investigation At A Quaternary Pediatric Hospital Following The Opening Of A Leed-Certified Critical Care Tower: Where Does Water Sustainability Intersect With Infection Control?, Andrea L Ankrum, Silvia M Caceres, Michael Torsell, Elaine Epperson, Vinicius Calado Nogueira De Moura, Michael Strong, Matthew J Strand, Rachel N Wilsey, Jennifer R Honda, Jane E Gross, Felicia A Scaggs-Huang
Mycobacterium Chelonae Outbreak Investigation At A Quaternary Pediatric Hospital Following The Opening Of A Leed-Certified Critical Care Tower: Where Does Water Sustainability Intersect With Infection Control?, Andrea L Ankrum, Silvia M Caceres, Michael Torsell, Elaine Epperson, Vinicius Calado Nogueira De Moura, Michael Strong, Matthew J Strand, Rachel N Wilsey, Jennifer R Honda, Jane E Gross, Felicia A Scaggs-Huang
Faculty, Staff and Student Publications
Objective: Investigate the increased incidence of Mycobacterium chelonae positive respiratory cultures in hospitalized patients.
Design: Apply the Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria (HALT NTM) toolkit to an outbreak investigation of M. chelonae.
Setting: Quaternary-care pediatric hospital and medical center in the United States with a recently opened LEED-certified critical care tower.
Patients: Adult and pediatric patients with M. chelonae positive respiratory cultures between June 2022 and January 2024.
Methods: An epidemiological investigation involving clinical and laboratory practices, water management, building construction and renovation projects. Environmental sampling of air vents, water sources and endoscope reprocessing equipment was performed. M. …
Stiefel Md Anderson Oropharynx Cancer (Mda-Opc) Cohort: A Single-Institution, Prospective Longitudinal Outcomes Study, Amy Moreno, Ariana J Sahli, Faye Johnson, Xiaowen Sun, Carly Barbon, Wenye Song, Han Liang, Jun Li, Wei Liu, J Jack Lee, S J Frank, Stephen Lai, Clifton Fuller, Katherine Hutcheson
Stiefel Md Anderson Oropharynx Cancer (Mda-Opc) Cohort: A Single-Institution, Prospective Longitudinal Outcomes Study, Amy Moreno, Ariana J Sahli, Faye Johnson, Xiaowen Sun, Carly Barbon, Wenye Song, Han Liang, Jun Li, Wei Liu, J Jack Lee, S J Frank, Stephen Lai, Clifton Fuller, Katherine Hutcheson
Faculty, Staff and Student Publications
Purpose: The MD Anderson Oropharynx Cancer (MDA-OPC) cohort is a unique single-institution, prospective longitudinal cancer cohort. The cohort aims to enhance the therapeutic index of OPC management by supporting data needs for independent investigators to conduct rigorous observational studies examining exposures and factors associated with acute and late toxicities, cancer progression, recurrence, new malignancies and quality of life in OPC survivors.
Participants: A total of 1811 patients with OPC with a minimum follow-up of 6 months have been consented to our prospective registry between 18 March 2015 and 29 December 2023. Clinical and treatment (Tx) data are available on all …
Live-Cell Quantitative Monitoring Reveals Distinct, High-Affinity Gβγ Regulations Of Girk2 And Girk1/2 Channels, Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Galit Tabak, Haritha P Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W Dessauer, Enno Klussmann, Yoni Haitin, Joel A Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal
Live-Cell Quantitative Monitoring Reveals Distinct, High-Affinity Gβγ Regulations Of Girk2 And Girk1/2 Channels, Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Galit Tabak, Haritha P Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W Dessauer, Enno Klussmann, Yoni Haitin, Joel A Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal
Faculty, Staff and Student Publications
Gi/o protein-coupled receptors (GPCRs) inhibit cardiac and neuronal excitability via G protein-activated K+ channels (GIRK), assembled by combinations of GIRK1 - GIRK4 subunits. GIRKs are activated by direct binding of the Gβγ dimer of inhibitory Gi/o proteins. However, key aspects of this textbook signaling pathway remain debated. Recent studies suggested no Gi/o-GIRK pre-coupling and low (>250 µM) Gβγ-GIRK interaction affinity, contradicting earlier sub-µM estimates and implying low signaling efficiency. We show that Gγ prenylation, which mediates Gβγ membrane attachment required for GIRK activation, also contributes to the Gβγ-GIRK interaction, explaining the poor affinity obtained with non-prenylated Gβγ. Using quantitative …
Analysis Of A Deeply-Phenotyped Familial Hypercholesterolemia Cohort From Mexico Shows A Role For Both Rare And Common Alleles Across Known Dyslipidemia Genes And Reveals Structural Variation In A Novel Locus, Nicholas Katsanis, Niki Mourtzi, Consuelo D Quinto-Cortés, Alexandro J Martagon, Alexander G Ioannidis, Jeff Gulcher, Mohammad A Faghihi, Arturo Lopez-Pineda, Sonia Moreno-Grau, Daniel Mas Montserrat, Míriam Barrabés, David Bonet, Pavel Salazar Fernandez, Jeff Wall, Babak Moatamed, Roopa Mehta, Gabriela A Galan-Ramirez, Rafael Zubirán, Daniel Elias-Lopez, Teresa Tusié-Luna, Carlos A Aguilar-Salinas, Carlos D Bustamante
Analysis Of A Deeply-Phenotyped Familial Hypercholesterolemia Cohort From Mexico Shows A Role For Both Rare And Common Alleles Across Known Dyslipidemia Genes And Reveals Structural Variation In A Novel Locus, Nicholas Katsanis, Niki Mourtzi, Consuelo D Quinto-Cortés, Alexandro J Martagon, Alexander G Ioannidis, Jeff Gulcher, Mohammad A Faghihi, Arturo Lopez-Pineda, Sonia Moreno-Grau, Daniel Mas Montserrat, Míriam Barrabés, David Bonet, Pavel Salazar Fernandez, Jeff Wall, Babak Moatamed, Roopa Mehta, Gabriela A Galan-Ramirez, Rafael Zubirán, Daniel Elias-Lopez, Teresa Tusié-Luna, Carlos A Aguilar-Salinas, Carlos D Bustamante
Faculty, Staff and Student Publications
Familial hypercholesterolemia (FH) is a genetic disorder driven in part by mutations in three genes that encode components of the cholesterol pathway: LDLR, APOB, and PCSK9. However, the majority of FH genetics has been performed in individuals of European descent. Here, we leveraged a cohort of 300 patients from the Mexican FH registry to understand how rare, high liability alleles and common variants might contribute to shaping individual risk. Using a combination of whole exome and of short- and long-read whole genome sequencing, we report three key findings. First, we observed that rare pathogenic point mutations and structural variants in …
Naphthalimide-Based Type-I Nano-Photosensitizers For Enhanced Antitumor Photodynamic Therapy: H2s Synergistically Regulates Pet And Self-Assembly, Huiyu Niu, Songnan Wang, Yang Liu, Nana Ma, Shuaiwei Cheng, Hyunsun Jeong, Ge Wang, Tony D James, Juyoung Yoon, Jonathan L Sessler, Hua Zhang
Naphthalimide-Based Type-I Nano-Photosensitizers For Enhanced Antitumor Photodynamic Therapy: H2s Synergistically Regulates Pet And Self-Assembly, Huiyu Niu, Songnan Wang, Yang Liu, Nana Ma, Shuaiwei Cheng, Hyunsun Jeong, Ge Wang, Tony D James, Juyoung Yoon, Jonathan L Sessler, Hua Zhang
Faculty, Staff and Student Publications
Photodynamic therapy (PDT) relies on a combination of light and photosensitizers (PSs) to achieve local control over cancerous lesions. However, it is subject to limitations, including tumor hypoxia, low tumor targeting, off‐target phototoxicity, and always‐on fluorescence. Here, we propose a design strategy for activated nano‐PSs (N‐PSs) to simultaneously overcome the limitations of PDT, wherein photoinduced electron transfer (PeT) is coupled with an endogenous H2S‐regulated self‐association process to promote Type‐I photochemical reactions. Using theoretical calculations, spectral analysis, and microscopic imaging, we verified the generation of self‐assembly and occurrence of PeT. And it was also shown that H2S could synergistically inhibit the …
Immigration And The U.S. Economy Under Obama And Trump, Eliz Gevorgian
Immigration And The U.S. Economy Under Obama And Trump, Eliz Gevorgian
Political Science Student Research
This paper examines the economic effects of the United States' immigration policy under President Barack Obama and President Donald Trump. Between 2009 and 2017, the Obama administration introduced programs such as Deferred Action for Childhood Arrivals (DACA) and expanded access to student and work visas. These actions coincided with steady GDP growth averaging about 2 percent per year and a decline in unemployment from 9.9 percent in 2009 to 4.7 percent in 2016. The Trump administration, in office from 2017 to 2021, implemented more restrictive immigration measures, including the 2017 travel ban, reduced refugee admissions, increased H1B visa scrutiny, and …
Profiling Tumour-Infiltrating Immune Cells In A Large Paediatric Medulloblastoma Cohort: A Retrospective Analysis, Jiao Zhang, Jirong Guo, Xiuchen Guan, Yu Sun, Wenhao Wu, Chunde Li, Yongji Tian, Yunwei Ou, Tian Li, Kai Jiang, Michael D Taylor, Xuebin Liao, Liwei Zhang, Tao Sun
Profiling Tumour-Infiltrating Immune Cells In A Large Paediatric Medulloblastoma Cohort: A Retrospective Analysis, Jiao Zhang, Jirong Guo, Xiuchen Guan, Yu Sun, Wenhao Wu, Chunde Li, Yongji Tian, Yunwei Ou, Tian Li, Kai Jiang, Michael D Taylor, Xuebin Liao, Liwei Zhang, Tao Sun
Faculty, Staff and Students Publications
Background: Tumour-infiltrating immune cells exert both pro-tumour and anti-tumour effects on intracranial tumours. In this study, we investigated the prognostic value of various infiltrating immune cells in medulloblastoma (MB) within a large cohort.
Methods: We employed multiplex immunofluorescent (mIF) staining of tissue microarrays to assess the densities of T cells, B cells, NK cells, macrophages, and immune checkpoints in tumour samples from 249 primary paediatric patients with primary MB. Overall survival (OS) analysis, progression-free survival (PFS), and Cox regression analyses were utilised to explore potential relationships between immune cell densities and survival outcomes. Subsequently, multivariate Cox regression was validated using …