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2025

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Predicting The Unpredictable: Advancing Risk Management In Fitness Centers Through Data Science-Driven Judicial Outcome Modeling, Hongyoung Kim Dec 2025

Predicting The Unpredictable: Advancing Risk Management In Fitness Centers Through Data Science-Driven Judicial Outcome Modeling, Hongyoung Kim

Health, Exercise, and Sports Sciences ETDs

This study developed a prediction model of judicial outcomes in fitness exercise-related injury lawsuits to identify key factors influencing fitness centers’ success in litigation. Using 209 U.S. court cases from Westlaw, Phase One employed text mining and content analysis to identify legal variables. Phase Two applied descriptive statistics and multiple logistic regression to evaluate the combined influence of these variables on judicial outcomes. For the multiple logistic regression analysis, the sample size was reduced to 184 cases after excluding 25 remanded cases.

Results showed that victim behavior, hazardous facility conditions, and enforceable waivers or exculpatory clause defenses significantly predicted judicial …


Can Web-Based International Standardized Tests Be More Inclusive? A Udl Mixed-Methods Study Of Accented Tasks, Abdelbaset Haridy Dec 2025

Can Web-Based International Standardized Tests Be More Inclusive? A Udl Mixed-Methods Study Of Accented Tasks, Abdelbaset Haridy

Language, Literacy, and Sociocultural Studies ETDs

This dissertation explores the critical, yet understudied, issue of using a variety of accents/dialects within standardized listening assessments. The current study argues for a paradigm shift from dominant accent to the use of a variety of accents in foreign language testing and assessment. The shift is guided by the principles of Universal Design for Learning (UDL), World Englishes, and Intercultural Communication Theory. Following a mixed-methods design, the study compares student perceptions (N=202) and experts’ (N=64) opinions across two distinct linguistic contexts: English and Arabic. College student participants rated listening samples across nine parameters, including Fluency, Accuracy, Comprehensibility, Intelligibility, and Approachability. …


Treating Atrial Fibrillation: Cryoballoon Vs. Radiofrequency Ablation, Nile A. Latowsky, Jordan E. Andre Dec 2025

Treating Atrial Fibrillation: Cryoballoon Vs. Radiofrequency Ablation, Nile A. Latowsky, Jordan E. Andre

Physician Assistant Capstones, 2020-current

Objective: Assess the effectiveness of pulmonary vein isolation (PVI) by cryoballoon ablation (CBA) compared to the current gold standard of care, radiofrequency ablation (RFA), for the treatment of paroxysmal and persistent atrial fibrillation in a symptomatic population. Design: Literature review. Methods: Searches were done in PubMed and Cochrane Library, utilizing the terms atrial fibrillation, cryoballoon ablation, and radiofrequency. In PubMed, the following limits and terms were used: published in the last 10 years, humans, randomized controlled trial, and English. Results: Search results revealed four studies meeting the inclusion/exclusion criteria. Conclusion: Cryoballoon ablation (CBA) is as efficacious in treating atrial fibrillation …


Non-Destructive Characterization Of Ion Irradiated Yttrium Hydride For Microreactor Applications, Ryan E. Pena Dec 2025

Non-Destructive Characterization Of Ion Irradiated Yttrium Hydride For Microreactor Applications, Ryan E. Pena

Nuclear Engineering ETDs

As energy demands increase, nuclear reactors, especially microreactors, become a promising energy source. These reactors run at high temperatures (>280°C), requiring moderators that can endure these environments. Yttrium hydride is a possible moderator, but little is known about the material’s phase stability and hydrogen retention under irradiation. Through the use of a gold ion beam, samples with stoichiometries ranging from 1.6 to 2.0 were irradiated and tested. Through Vickers hardness testing, a model was created showing a correlation between hydrogen content and hardness. Raman spectroscopy showed high temperature and irradiated samples have significant hydrogen loss. XRD quantified this hydrogen …


Sequential Low Dose Proton Irradiation And Nanomechanical Testing To Understand Mechanical And Microstructural Property Changes In Alloy 709, Abhishek Kc Dec 2025

Sequential Low Dose Proton Irradiation And Nanomechanical Testing To Understand Mechanical And Microstructural Property Changes In Alloy 709, Abhishek Kc

Nuclear Engineering ETDs

Alloy 709, a 20Cr25Ni alloy, is an advanced austenitic steel designed for next generation sodium fast reactors. Preliminary studies have shown the potential of Alloy 709 in sodium fast reactors. In this study, Precipitate Treated Alloy 709 specimens are irradiated with 2 MeV H+ at 500 °C from 0.0057 dpa to 1.7 dpa. Electron microscopy characterization techniques are used to understand the effects of radiation on mechanical properties as well as microstructure of Alloy 709. The microstructure did not show formation of voids, amorphization of precipitates, or increase in grain size up to 1.7 dpa. Correspondingly nano-indentation and micro-pillar …


Coupled Adjoint-Based Perturbation Theory For Dynamics And Heat Transfer Multiphysics For Nuclear Transients, Alexis Maldonado Dec 2025

Coupled Adjoint-Based Perturbation Theory For Dynamics And Heat Transfer Multiphysics For Nuclear Transients, Alexis Maldonado

Nuclear Engineering ETDs

Nuclear reactor multiphysics modeling and simulation (M&S) enable advanced reactor design by analyzing how systems will react over time to various configurations, scenarios, and perturbations. However, high-fidelity coupled transient M&S for reactor cores are computationally expensive, making robust analyses challenging. This work develops a Coupled Adjoint-based Perturbation Theory for dynAmIcs and heat traNsfer (CAPTAIN) framework to rapidly quantify the impact of uncertainty to overall transient responses by generating sensitivity coefficients for temperature, power, and delayed neutron precursor concentrations using forward and adjoint solutions. This work presents an initial proof of principle, verified with direct perturbations to several inputs. Furthermore, this …


A Risk-Informed Approach To Performing The Pre-Closure Safety Analysis For The Deep Borehole Disposal Of Radioactive Waste, Jennifer Elizabeth Leute Dec 2025

A Risk-Informed Approach To Performing The Pre-Closure Safety Analysis For The Deep Borehole Disposal Of Radioactive Waste, Jennifer Elizabeth Leute

Nuclear Engineering ETDs

Deep borehole disposal is an emerging concept which involves disposing of radioactive

waste in boreholes several kilometers deep then backfilling to minimize radionuclide

transport and distribute weight. Unfortunately, little documentation exists on borehole

safety case development, especially for pre-closure operations. This study aims to close

this gap by proposing a graded approach matrix based on consequence, maturity, and

complexity. Two case studies are used to demonstrate this application: Hanford CsCl

capsules and spent PWR assemblies. Simulations are used to predict potential for dose

exposure, revealing CsCl capsules have a much higher potential for being above the 5

rem public dose …


Modeling Mineral Redistribution In Biological Tissue Using Apple As An In Vitro Analogue, Daler Djuraev, Ali Algemsh, Halima Alazeb, Zeenia Ahmed Dec 2025

Modeling Mineral Redistribution In Biological Tissue Using Apple As An In Vitro Analogue, Daler Djuraev, Ali Algemsh, Halima Alazeb, Zeenia Ahmed

Publications and Research

This project aims to model mineral (ion) redistribution that occurs in human soft tissue after injury or mechanical/thermal stress. Because direct, repeatable in vivo measurements are difficult, we use apples as an in vitro analogue: their mineral content is relatively uniform and the tissue can be cut, dried, and repeatedly imaged under controlled conditions. Using X-ray imaging, we tracked how minerals in apple tissue move toward damaged regions immediately after cutting, and how subsequent drying at room temperature drives a redistribution toward the central core. We also observed that biological degradation (decay) alters mineral density over time, indicating that even …


Using Vaginal Cytology To Confirm Estrus In Swine - Pilot Study, Carly J. Johnson Dec 2025

Using Vaginal Cytology To Confirm Estrus In Swine - Pilot Study, Carly J. Johnson

Honors College Theses

This study aims to determine whether there is a correlation between cellular changes observed in vaginal cytology and the physical signs of estrus in swine. Vaginal cytology is a technique commonly used in dogs, cats, and rodents, and if proven effective in swine, it could serve as a practical tool for producers to confirm estrus status and improve reproductive management.


Travels In West Africa: A Critical Edition, Erere Iwhi Dec 2025

Travels In West Africa: A Critical Edition, Erere Iwhi

Student Works

First published in 1897, Mary Henrietta Kingsley’s Travels in West Africa became one of the most influential travel narratives of the Victorian era, changing the way British audiences encountered accounts of West Africa and its peoples. This critical edition examines the book not only as a travel narrative but also as a material artifact shaped by the historical, publishing, and cultural networks that guided its production, circulation, and reception. Extending its analysis beyond Kingsley's experiences of exploration, this edition investigates the forces behind the book’s creation, including Kingsley’s intellectual development, her identity as an independent female traveler and writer, and …


Patient-Derived Ovarian Cancer Models Provide Insight Into Cancer Cell-Intrinsic And Immune Cell-Dependent Effects On Therapeutic Response, Parisa Nikeghbal Dec 2025

Patient-Derived Ovarian Cancer Models Provide Insight Into Cancer Cell-Intrinsic And Immune Cell-Dependent Effects On Therapeutic Response, Parisa Nikeghbal

Biomedical Sciences ETDs

Ovarian cancer is the most lethal gynecologic malignancy, largely due to late diagnosis and resistance to chemotherapy. This dissertation applies patient-derived organoids (PDOs), xenograft-derived organoids (PDXOs), and humanized xenografts (huPDX) to investigate therapeutic responses and immune interactions. Organoids were shown to retain critical features of the original malignancy. Across platinum-sensitive, -resistant, and -refractory cases, both PDOs and PDXOs exhibited drug sensitivities that aligned with patients’ clinical classifications. Building on this foundation, a drug screen revealed novel strategies. Auranofin restored platinum sensitivity in Notch3-active models, afatinib broadly reduced viability, and adavosertib–gemcitabine and sorafenib–topotecan combinations produced synergy. Extending this work, immune interactions …


Parameter-Efficient Multimodal Adaptation: Ocr-Integrated Lora For Textvqa And Captioning, Karthik Ganesh Malini Dec 2025

Parameter-Efficient Multimodal Adaptation: Ocr-Integrated Lora For Textvqa And Captioning, Karthik Ganesh Malini

Master's Theses

Vision-Language Models (VLMs) have emerged as transformative technologies for multimodal AI, yet they face significant hurdles in processing text-rich images required for enterprise applications like document understanding, medical imaging, and industrial inspection. Current VLMs struggle with accurate text extraction and reasoning, often exhibiting high hallucination rates and poor Optical Character Recognition (OCR) token utilization. To address these limitations, this research presents a comprehensive framework for optimizing parameter-efficient Low-Rank Adaptation (LoRA) fine-tuning strategies on state-of-the-art architectures, including LLaVA-1.5 and BLIVA-FlanT5. Our methodology integrates enhanced OCR token utilization, faithful caption generation, and specific hallucination mitigation techniques. We employ a multi-dimensional evaluation protocol …


Instrumental Music Educator Strategies To Reduce Or Remove Participation Barriers For Middle School Students, Rachel A. Gorden Mercer Ed.D Dec 2025

Instrumental Music Educator Strategies To Reduce Or Remove Participation Barriers For Middle School Students, Rachel A. Gorden Mercer Ed.D

Doctorate in Education

Scholars have found that students who participate in instrumental music programs achieve higher academic levels, have better attendance, and build stronger community connections than students who do not participate. This dissertation examines successful strategies for increasing participation in instrumental music programs by reducing socioeconomic barriers, enhancing instrument access, creating ensemble opportunities, and fostering a positive culture within the instrumental program for students during the middle school years. Music educators have found successful strategies to recruit and retain students despite the barriers they encounter.

Researchers have investigated the benefits of participating in instrumental music and the reasons why students discontinue their …


Graph Based Planning With Guarantees, Trazon Tyrik Jimerson Dec 2025

Graph Based Planning With Guarantees, Trazon Tyrik Jimerson

Mechanical Engineering ETDs

This thesis presents two graph-based methods with formal guarantees for motion planning and routing. First, the invariant-set motion planner (ISMP), which uses constraint admissible positive invariant (CAPI) sets of closed-loop dynamics, is adapted for spacecraft attitude planning to avoid moving keep-out zones. Contributions include time bounds for maneuvers via exponential stability, a single-stage reachability graph from one-step backward reachable CAPI sets, and its multi-stage expansion to certify node safety over time. Simulations verify safe attitude control with moving obstacles. Second, we formulate a convex optimization problem over a network for evacuation planning with operational constraints such as helicopter capacity and …


Real-Time Frequency Tuning Of Kinetic Energy Harvesters Via System Mass Adjustment, Rahul Adhikari Dec 2025

Real-Time Frequency Tuning Of Kinetic Energy Harvesters Via System Mass Adjustment, Rahul Adhikari

Mechanical Engineering ETDs

This research presents a method for real-time frequency tuning of piezoelectric kinetic energy harvesters through system-mass adjustment. Custom 3D-printed proof masses with cavity arrays were used to redistribute solid or liquid mass, enabling controlled modification of resonant frequency. Experimental studies using microparticles and liquids—including water, silicone oil, and sodium polytungstate—demonstrated an achievable tuning range of 115.27 Hz with sub-hertz resolution (< 0.1 Hz), confirming precise and repeatable frequency control. Finite-element modeling guided design optimization, while a microfluidic channel system enabled automated liquid filling for real-time operation. A MATLAB-based EH_Tuning application was developed to visualize and predict frequency responses. The combined …


Design And Development Of Evacuated Photovoltaic-Thermal Systems For Efficient Cogeneration Of Heat And Electricity, Behnam Roshanzadeh Dec 2025

Design And Development Of Evacuated Photovoltaic-Thermal Systems For Efficient Cogeneration Of Heat And Electricity, Behnam Roshanzadeh

Mechanical Engineering ETDs

In conventional PV systems, most of the solar energy is dissipated into the environment as heat. Accordingly, hybrid Photovoltaic-thermal systems have been developed to utilize the waste heat from PV cells for various thermal applications. However, most PVT systems suffer from low thermal performance compared to solar thermal collectors, as the absorber plate in PVT systems is partially or fully covered by PV cells. This dissertation focuses on improving the thermal performance of PVT systems by introducing the evacuated PVT systems.

An evacuated-tube PVT system was designed and simulated for domestic hot water supply. The evacuated-tube PVT system demonstrated 40% …


Efficacy Of Oil And Gas Production Site Remediation In U.S. Arid/Semi-Arid Regions, Skye Ontiveros Dec 2025

Efficacy Of Oil And Gas Production Site Remediation In U.S. Arid/Semi-Arid Regions, Skye Ontiveros

Architecture and Planning ETDs

Oil and gas production (OGP) is expanding, paralleled by its polluting leaks and spills (LS), and outpaced by its waste. This raises the question: Does remediation of LS occur effectively when needed to protect the environment and public, particularly in major producing regions like arid/semi-arid regions (ASAR), which account for approximately 72% of US oil and 42% of gas production? To answer, a review of the eight largest national remedial laws, sourced from the Code of Federal Regulations (CFR), identified 14 OGP exemptions for remedial determinants (RDs): factors affecting remedial frequency and efficacy (e.g. LS monitoring and chemical disclosure). An …


Pediatric Obstructive Sleep Apnea And The Role Dental Hygienists Play In Achieving Optimal Health And Quality Of Life: A Pilot Study, Kari S. Roth Dec 2025

Pediatric Obstructive Sleep Apnea And The Role Dental Hygienists Play In Achieving Optimal Health And Quality Of Life: A Pilot Study, Kari S. Roth

Dental Hygiene ETDs

ABSTRACT

The purpose of this study was to evaluate the current practice, confidence, barriers, and experience of dental hygienists who screen or identify signs, symptoms, and risk factors of those who struggle with pediatric obstructive sleep apnea. This study was designed to provide a brief perspective to identify gaps or needs for improvement in dental hygiene practice. Members of the American Dental Hygienists’ Association participated in an electronic survey. While 231 participants responded, most reported some familiarity with obstructive sleep apnea in children, but many are unaware of guidelines from other professional organizations for screening protocols. Results depict a lack …


Hearing Their Voices: Exploring Parent Perspectives Regarding Augmentative And Alternative Communication In Home And Community Contexts, Heather Rose Diluzio Dec 2025

Hearing Their Voices: Exploring Parent Perspectives Regarding Augmentative And Alternative Communication In Home And Community Contexts, Heather Rose Diluzio

Special Education ETDs

Parents of children who have extensive support (ESN) who use augmentative and alternative communication (AAC) have reported challenges in supporting their children’s communication in home and community contexts. This qualitative interview study explored the perspectives of six mothers of children with ESN who use aided AAC to examine the supports families have, or would like to have, to integrate aided AAC meaningfully into their child’s communication in home and community settings. Findings revealed that these parents were the primary force behind their child’s access to aided AAC due to limited support from formal systems and professionals. Themes included: parents’ deep …


“Sin Tener Que Gastar”: Un Restaurante Gourmet En Nueva York Donde Pagas Lo Que Puedas, Oscar Alberto Flores Dec 2025

“Sin Tener Que Gastar”: Un Restaurante Gourmet En Nueva York Donde Pagas Lo Que Puedas, Oscar Alberto Flores

Capstones

Community Kitchen es un restaurante piloto gourmet en el Lower East Side de Nueva York que funciona bajo un modelo de “paga lo que puedas”, creado por el reconocido periodista gastronómico Mark Bittman. Ubicado en un vecindario marcado por una profunda desigualdad económica y altos niveles de inseguridad alimentaria, el proyecto busca demostrar que la comida de alta calidad puede ser accesible para personas de todos los ingresos. A través de un menú sostenible, precios flexibles, apoyo a agricultores locales —en su mayoría BIPOC— y salarios justos para jóvenes cocineros, Community Kitchen combina gastronomía, justicia social y comunidad. En …


Halt Under Threat Why Legislators Must Demand Compliance Before Change A Playbook For Action, Vanda Seward Dec 2025

Halt Under Threat Why Legislators Must Demand Compliance Before Change A Playbook For Action, Vanda Seward

Capstones

This playbook examines the implementation of New York State’s Humane Alternatives to Long-Term Solitary Confinement (HALT) Act and presents evidence demonstrating that the law has not been fully or consistently enforced by the New York State Department of Corrections and Community Supervision (NYSDOCCS). Drawing on findings from the New York State Inspector General, the Correctional Association of New York, the Justice Center, court rulings, and community testimony, the analysis documents persistent violations, including excessive and illegal use of solitary confinement, inadequate documentation, failures to protect vulnerable populations, and insufficient accountability for staff misconduct. The playbook critically evaluates the recommendations of …


What’S That Smell? It’S Climate Change!, Perry Gregory Dec 2025

What’S That Smell? It’S Climate Change!, Perry Gregory

Capstones

Climate change is going to make New York City smell worse. Reporter Perry Gregory breaks down the process of olfaction and explains how heat affects what we smell. The piece features a collage of voices of New Yorkers describing the current smell profile of the city. The report features insight from several Atmospheric Scientists into why New York City is getting hotter and more humid, and how those climate changes will make the existing smells of the city stronger, and worse. The most economically vulnerable New Yorkers, who cannot afford air conditioning to buffer them from heat, will be the …


Curious Contradictions: A Critical Edition Of 'The Great War In England In 1897,' By William Le Queux, Jacob D. Liljenquist Dec 2025

Curious Contradictions: A Critical Edition Of 'The Great War In England In 1897,' By William Le Queux, Jacob D. Liljenquist

Student Works

Written by William Le Queux in 1894, The Great War in England in 1897 is a work of invasion literature, and a book full of curious contradictions. Once popular and now forgotten, its material construction belies its status as sensational literature. This critical edition of the 4th edition copy of the novel housed in the L. Tom Perry Special Collections evaluates the book's conception, creation, and reception, and provides a material bibliography of the HBLL's unique copy, all with the aim to reveal and explain the contradictions in the book as a product of imperial culture.


Analysis Of Heat Transfer And Pressure Drops Associated With Twisted Tube Heat Exchangers, Braden Foderaro Dec 2025

Analysis Of Heat Transfer And Pressure Drops Associated With Twisted Tube Heat Exchangers, Braden Foderaro

Nuclear Engineering ETDs

Several studies have been done on the effects of twisted tubes in heat exchangers, including the correlations that relate the flow parameters to the heat transfer and pressure drop experienced. These studies are new, with the earliest being performed in 1982. As such, there are many correlations covering only certain flow parameters and geometrical configurations such as the Reynolds number and modified Froude number.

This thesis attempts to cover flow regimes and tube geometries not yet studied and yield correlations. Data are gathered from heat exchangers featuring twisted tubes with water as the working fluid. It is noticed that the …


Stress During Adolescence: A Characterization Of Anxiety-Like Behavior, And The Mrna Expression Of Neuroimmune Factors, Clock And Stress Genes In Corticolimbic Areas., Annette Fernandez Oropeza, Annette K. Fernandez Oropeza Dec 2025

Stress During Adolescence: A Characterization Of Anxiety-Like Behavior, And The Mrna Expression Of Neuroimmune Factors, Clock And Stress Genes In Corticolimbic Areas., Annette Fernandez Oropeza, Annette K. Fernandez Oropeza

Biomedical Sciences ETDs

Adolescence represents a critical window of frontal cortex (FC) maturation and corticolimbic circuit refinement that supports stress and emotion regulation. Disruption of these processes by early-life insults such as prenatal alcohol exposure (PAE) or adolescent stress increases vulnerability to anxiety and mood disorders, in part through circadian–immune dysregulation. The circadian transcription factor Bmal1 and the proinflammatory cytokine tumor necrosis factor-alpha (TNFα) have emerged as key regulators of neuroimmune signaling and synaptic communication, yet their interactions across developmental risk contexts remain poorly understood. This dissertation examined the effects of mild adolescent isolation stress, with and without PAE, on anxiety-like behaviors and …


Praise With Pipes And Strings: An Exploration Of American Protestant Hymnody Through New Arrangements For Flute And Piano, Dominic J. Baldoni Dec 2025

Praise With Pipes And Strings: An Exploration Of American Protestant Hymnody Through New Arrangements For Flute And Piano, Dominic J. Baldoni

Dissertations, 2020-current

This project presents five hymn tunes from the American Protestant (A.P.) tradition arranged for flute and piano, accompanied by a scholarly analysis of the historical, liturgical, and practical aspects of A.P. hymnody and congregational song. The accompanying document explores the development of A.P. hymnody, the background of each selected tune, the role of instruments, primarily the flute, in worship, and the challenges faced by church musicians in the twenty-first century. By examining both vocal and instrumental iterations of these melodies throughout history, the analysis aims to inform performers and program planners about stylistic and contextual considerations for contemporary services and …


Corporeality In Choral Sound: Elements Of Consonant Diction Shaping Pre-Expressive Presence, Perceived Clarity, And Expression In English-Language Choral Music, Addison Walton Dec 2025

Corporeality In Choral Sound: Elements Of Consonant Diction Shaping Pre-Expressive Presence, Perceived Clarity, And Expression In English-Language Choral Music, Addison Walton

Dissertations, 2020-current

The genesis of this project stems from a lived experience performing with a professional choir, whose sung physical shaping of the English language—its crystalline clarity, profound expressivity, and the pre-expressive elements inherent in the delivery—was deeply and viscerally compelling. This overwhelming reaction was in response to their bodies; specifically, the sound their bodies produced that evoked a sense of corporeality, or tangible bodily presence. There was beauty to be found in the way their mouths physically formed the language, both within and removed from the semantic context.

This study sought to acknowledge those fleeting, pre-expressive moments in choral music and …


Irregularities In The Dynamics Of Large Networks: Cases On Social Networks And The Internet, Dheeman Saha, Abdullah Mueen, Shuang Luan, Afsah Anwar, Yangsun Hong Dec 2025

Irregularities In The Dynamics Of Large Networks: Cases On Social Networks And The Internet, Dheeman Saha, Abdullah Mueen, Shuang Luan, Afsah Anwar, Yangsun Hong

Computer Science ETDs

Dynamic networks capture evolving relationships among entities, and irregularities in their behavior often signal significant events. This dissertation investigates such irregularities across social and infrastructural networks. First, we analyze Twitter (prior to its rebranding to X) to characterize influencers, introducing a follower-overlap similarity measure that identifies micro-influencers beyond content-based methods.

We then examine election-related irregularities by comparing suspended and non-suspended accounts during the 2020 U.S. presidential election, revealing behavioral patterns linked to misinformation and coordinated manipulation.

Next, we develop an algorithm to infer post-specific diffusion networks, reconstructing who-saw-from-whom pathways for tweets at scale. This method uncovers structural differences in diffusion …


The Pathophysiological Role Of Mitochondrial Acid-Sensing Ion Channel 1a In Hypoxic Pulmonary Hypertension, Megan N. Tuineau Dec 2025

The Pathophysiological Role Of Mitochondrial Acid-Sensing Ion Channel 1a In Hypoxic Pulmonary Hypertension, Megan N. Tuineau

Biomedical Sciences ETDs

Pulmonary hypertension (PH) is characterized by increased pulmonary arterial constriction, pulmonary arterial remodeling, and right ventricular dysfunction. While metabolic and mitochondrial derangements are increasingly recognized as central pathogenic features, the underlying mechanisms and effectors are not yet fully understood. Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel involved in the development of chronic hypoxia (CH)-induced PH. ASIC1a represents a potential candidate involved in metabolic-mitochondrial dysfunction, as metabolic byproducts can act as ligands for ASIC1a. Additionally, ASIC1a has recently been identified as a mitochondrial ion channel involved in neuronal death following oxidative stress. Therefore, we hypothesize that ASIC1a functions …


Grappling With Parenthood In 2025, Elisa Muyl Dec 2025

Grappling With Parenthood In 2025, Elisa Muyl

Capstones

In 2024, I became a parent for the first time. Within the first year of my child's life, president Trump was elected for a second term and came into office on the back of a right-wing project to “restore” the American family as the central unit of American life. I knew instinctively that the values and policies this project espoused would not work for my family or many others. At the same time, I was grappling with a profound sense of social alienation and the lack of structural support for new parents, exacerbated by the way that community is sustained …