Digital Commons Network^™

Investigating Chronic Toxicity, Diet, Patient-Reported Outcomes And The Microbiome In Immunotherapy-Treated Metastatic Melanoma Survivors: A New Frontier, Margaux Robert, Satabdi Saha, Nazli Dizman, Michelle Rohlfs, Elizabeth Sirmans, Julie Simon, Rodabe N Amaria, Isabella C Glitza Oliva, Hussein A Tawbi, Michael A Davies, Alexandra Ikeguchi, Karen Basen-Engquist, Keri Schadler, Michael E Roth, Wenye Song, Xiaotao Zhang, Nadim J Ajami, Lorenzo Cohen, Jennifer A Wargo, Christine B Peterson, Jennifer L Mcquade, Carrie R Daniel

Faculty, Staff and Student Publications

Background/Objectives: Immune checkpoint blockade (ICB) therapies have significantly improved outcomes in metastatic melanoma. However, immune-related adverse events (irAEs) and persistent chronic toxicities (CTs) among this emerging survivor population likely influence different facets of quality of life. This study characterized CT, patient-reported outcomes (PROs), diet, physical activity and gut microbiome features in a cohort of long-term survivors with a history of ICB-treated metastatic melanoma.

Methods: Forty-eight patients with a history of metastatic melanoma who initiated ICB treatment at least 3 years earlier and were not currently on treatment were prospectively enrolled from a melanoma survivorship clinic. Participants completed screening …

Multipacking On Graphs And Euclidean Metric Space, Sk Samim Islam

Doctoral Theses

A multipacking in an undirected graph G = (V,E) is a set M ⊆ V such that for every vertex v ∈ V and for every integer r ≥ 1, the ball of radius r around v contains at most r vertices of M, that is, there are at most r vertices in M at a distance at most r from v in G. The multipacking number of G is the maximum cardinality of a multipacking of G and is denoted by mp(G). The MULTIPACKING problem asks whether a graph contains a multipacking of size at least k. For more …

Mapping Sustainability To Cybernetic-Generative Artificial Intelligence-Based Education: An Innovative Neutrosophic Orbifold-Lattice Methodology, Mona Mohamed, Ahmed A. Metwaly

Neutrosophic Systems with Applications

The lightning-fast development of artificial intelligence (AI), notably generative artificial intelligence (Gen AI) technologies, has intrigued multiple disciplines, particularly education. In this context, Large Language Models (LLMs) serve as beneficial cognitive resources that address knowledge deficits and provide tailored educational support for learners and staff. For learners, LLMs are regarded as knowledgeable educators who offer prompt, focused responses and rationales to tricky queries. Whereby LLMs for staff, Strength enhancer, automating tedious tasks, and creating intelligent resources.Gen AI’s rapid growth offers enormous obstacles for educational systems, compelling them to discover solutions for these obstacles.

Conceptually, cybernetics is leveraged for bridging the …

Shoreview Holdings, Llc V. Fernandez

All Decisions

Landlord initiated a holdover proceeding, claiming exemption from GCEL as a "small landlord." Tenant moved to dismiss, arguing landlord's failure to comply with LLC law publication requirements, misdescription of premises, exceeding the "small landlord" unit count, and non-compliance of the predicate notice and petition with GCEL's ownership disclosure requirements. The court denied tenant's motion, ruling that late compliance with LLC law cures the defect, that premises description issues were amendable or triable, and that GCEL requires ownership disclosure in the petition (which can be amended) but not the predicate notice. The court granted landlord's motion to amend its affirmation and …

Re: Comment Letter For Butte Priority Soils Operable Unit (Bpsou) Draft Interim Site-Wide Surface Water Monitoring Quality Assurance Project Plan (Qapp) (Dated November 24, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

An Algorithm For Extracting Bathymetry From Icesat-2 Data That Employs Structure And Density Using Concentric Ellipses, Yuri Rzhanov, Kim Lowell

Faculty Publications

The ICESat-2 satellite collects LiDAR data along linear orbital tracks using a photon-counting green wavelength (532.27 nm) instrument. The utility of combining ICESat-2 data with satellite imagery for training and subsequently applying satellite-derived bathymetry models to provide estimates of shallow water depth is well-established. However, automating and improving the accuracy of the identification of ICESat-2 photon events (PEs) representing bathymetry remains a challenge. This article presents an algorithm for automated extraction of PEs reflected from the ocean floor (rather than the ocean surface or noise in the water column). The algorithm is unique in examining both the density of PEs …

Cache-Conscious Sparse Matrix Dense Matrix Multiplication On Gpus, Haoqiang Guo

LSU Doctoral Dissertations

Over the past decade, high-performance deep learning has evolved into a critical research domain, driven by the demand for efficient models and high inference throughput. Deep learning architectures have shifted from stacked convolutional layers to transformer-based models, while pruning techniques and graph-structured data have established sparse matrix–dense matrix multiplication (SpMM) as a fundamental kernel—particularly in graph neural networks (GNNs). Modern GPUs, with their massive parallelism and high-bandwidth memory, offer immense potential for accelerating these workloads. While SpMM implementations using the compressed sparse row (CSR) format remain common to avoid conversion overhead, preprocessing-based methods have recently demonstrated superior potential. In GNN …

Discovery Of 5‑Chlorotryptophan-Containing Antibiotics Through Metabologenomics-Assisted High-Throughput Screening, Chantal D Bader, Isao Masuda, Angela Nichols, Edward Kalkreuter, Dong Yang, Thomas Christian, Yuko Nakano, Ya-Ming Hou, Ben Shen

Department of Biochemistry and Molecular Biology Faculty Papers

Actinomycetota bacteria have specialized in the biosynthesis of antibacterial natural products (NPs), and extract and fraction libraries made from those strains remain a promising source of NP drug leads. Herein, we present a high-throughput screen (HTS), based on engineered Escherichia coli strains expressing the human (Trm5) or bacterial (TrmD) m¹G37 tRNA methyltransferase, to discover NPs as novel anti-Gram-negative antibiotic leads. To harness the evolution of NPs with in vivo activity, the cell-based phenotypic HTS was applied to the Actinomycetota extract and fraction library at the Natural Products Discovery Center (NPDC), the Herbert Wertheim UF Scripps Institute for Biomedical …

Current Controversies On Adequate Circulating Vitamin D Levels In Ckd, Adriana S Dusso, Daniela J Porta, Carlos Bernal-Mizrachi

2020-Current year OA Pubs

Management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) has evolved dramatically over the past five decades, driven by discoveries that have fundamentally reshaped our understanding of the vitamin D endocrine system and its role in disease progression. This review synthesizes the key pathophysiological insights and clinical evidence underlying three critical paradigm shifts. The first shift moved beyond simple calcitriol replacement with the development of selective vitamin D receptor activators (VDRAs) designed to minimize hypercalcemia while maximizing PTH suppression. Crucially, these analogs revealed unexpected survival benefits, suggesting protective VDR actions extending beyond mineral metabolism. The second shift recognized the …

Acl Injuries In Major League Soccer: A 10-Year Analysis Of Injury Rate And Return To Play, And Performance Metrics By Player Position, Brian Forsythe, Catherine Hand, Camden Bohn, Francis Hand, Vahram Gamsarian, Daanish Khazi-Syed, Joshua Chang, Vikranth Mirle, Eric Giza, Robert Brophy, Danyal Nawabi, Bert Mandelbaum

2020-Current year OA Pubs

BACKGROUND: Anterior cruciate ligament (ACL) injuries are among the most debilitating injuries in professional soccer, often leading to extended recovery times and performance impacts. While much is known about ACL injury outcomes in European leagues, data specific to the Major League Soccer (MLS) remains limited.

PURPOSE/HYPOTHESIS: This study aimed to assess the return to play (RTP) times, RTP rates, and performance outcomes after ACL reconstruction in MLS athletes. It was hypothesized that RTP times would improve over the study period and that player performance would stabilize by the third post-injury season, consistent with findings from other professional soccer leagues.

STUDY …

Gated Multi-Source Forcing For Auto-Regressive Sequence Generation, Victor Carbune, Florian Hartmann

Defensive Publications Series

In decentralized machine learning environments, a local model's auto-regressive sequence generation may have performance limitations compared to a larger, centralized model, as it could lack a mechanism to leverage external knowledge during inference. A gated, multi-source forcing mechanism can dynamically evaluate a local model's uncertainty during the generation process, for example, by calculating prediction entropy. If uncertainty exceeds a configurable threshold, a token may be retrieved from an external teacher source, such as a remote centralized model or an on-device data corpus. This retrieved token can then be injected into the local model's decoding stream to guide its subsequent generation. …

Parallel Speculative Reasoning With Variable Budgets In Generative Models, Victor Carbune, Florian Hartmann

Defensive Publications Series

Generative models employing a sequential internal reasoning process with a fixed computational budget may experience latency or produce lower-quality outputs. A system for parallel speculative decoding with variable budgets can analyze an input prompt to predict a distribution of potential computational budgets and subsequently initiate multiple decoding streams in parallel, where each stream may be conditioned on a different budget from the distribution. An early termination mechanism can monitor the parallel streams and select a response from a stream that finishes its generation process, without waiting for more computationally intensive streams to complete. This technique can manage the trade-off between …

Structure-Based Repurposing Of Clinically Approved Compounds For Pde-5 Inhibition: Integrative Computational And Pharmacokinetic Evaluation, Albashir Tahir, Yasir Idris Saleh, Ibrahim Khaleel Muazu

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Phosphodiesterase-5 (PDE-5) regulates intracellular cyclic guanosine monophosphate (cGMP) levels, modulating vascular smooth muscle tone. Sildenafil, a well-established PDE-5 inhibitor, is effective for erectile dysfunction and pulmonary hypertension but causes dose-dependent adverse effects. Identifying alternative scaffolds with comparable efficacy and improved safety remains a pharmacological priority.

Methods: A ligand-based virtual screening of the DrugBank database was performed using sildenafil as a reference. Compounds exhibiting ≥60% structural and electrostatic similarity were docked into the PDE-5 catalytic domain (PDB ID: 2h42) using Glide XP in the Schrödinger Suite. Top-scoring ligands were assessed for physicochemical, pharmacokinetic (ADMET), and toxicity parameters using SwissADME and …

History And Prevention Of Foot-And-Mouth Disease Virus In Iraq: A Review, Ashwaq M. S. Al-Jbouri, Baraa Hamid Hadi, Saad Mardi Muhammad, Raoof J. A. Maaroof, Nada Khazal K. Hindi, Karrar Kamoona, Zainab Ayad, Rusul Ahmed Mohammed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Foot-and-mouth disease Virus (FMDV) is an extremely transmittable viral illness that affects cloven-hoofed faunae, such as cattle, goats, sheep, and pigs. This study aimed to demonstrate the history and prevention of foot-and-mouth disease (FMD) in Iraq. This virus poses a significant threat to the economy, necessitating strict measures to control and prevent its spread, particularly due to its high morbidity and mortality rates, especially in young faunae. It is one of the most contagious diseases as it is transmitted directly or indirectly from a diseased fauna to a healthy one through contact with resources contaminated with the virus, such as …

The Burning, Liane Carlo R. Suelan

Kritika Kultura

No abstract provided.

Bella Ciao, Máno Dela Cruz

Kritika Kultura

No abstract provided.

Ekphrasis By Sand, Buwan Sayajon

Kritika Kultura

No abstract provided.

Metamorfascis, Kristine Ong Muslim

Kritika Kultura

No abstract provided.

Willie “I’M Just A Ceo” Cruz Meta, Doomscrolling, And Social Marketing Solutions And Social Marketing Solutions, Lawrence Bernabe

Kritika Kultura

No abstract provided.

Willie “Ceo Lang Ako” Cruz Meta, Doomscrolling, And Social Marketing Solutions, Amado Anthony G. Mendoza Iii

Kritika Kultura

No abstract provided.

Saranghae, Monina Morales!, Kaisa Aquino

Kritika Kultura

No abstract provided.

Whose Story Is It? Postcolonial Racialization, Social (Im)Mobility, And Crony Capitalism In Tash Aw’S Five Star Billionaire, Chi Miao

Kritika Kultura

Malaysian Chinese author Tash Aw’s novel Five Star Billionaire narrates the stories of five Malaysian Chinese individuals striving to establish themselves in Shanghai by seeking opportunities for advancement, economic prosperity, and personal transformation. Drawing from Dan Shen’s narratological theory of dual narrative dynamics, which states how texts can have overt and covert narrative progressions, this article elucidates the novel’s hidden agenda by exploring how the characters’ experiences in contemporary China are intricately connected to their past in Malaysia. If interpreted according to the narrative’s overt progression, Five Star Billionaire depicts individuals who are enticed and ensnared by the forces of …

Restoring A Cultural Wetland With Poetry: How Huahai Writes And Acts With A Chinese Environmental Conscious, Qingqi Wei

Kritika Kultura

My translation of Huahai—a Chinese ecological poet who is both an artist and activist—has revealed his environmental insights that are meant to be ecocritical, cross-cultural, and practically constructive. His “Twenty-Four Solar Terms”1 sound structurally at a natural pace with the seasonal changes, tune the poetic rhythms with those of the solar terms, and exude the essence of national culture without preaching archaic and complex moralities. Equally important is the poet’s anxieties based on a broader context of climate change in that he critically emphasizes excessive human activities. His concerns with global warming explicitly strike a chord with contemporary readers during …

Judicial Discretion And Ultra Petita In Employment Termination Cases: Lessons From Dutch Arbitration System, Laode Muhammad Sabur, Abdul Razak, Hamzah Halim, Jamhur

Hasanuddin Law Review

The principle of ex aequo et bono occupies a unique position within Indonesia’s legal landscape: although not expressly codified, it is increasingly invoked by judges to pursue substantive justice in employment termination disputes. This judicial practice, however, raises concerns regarding legal certainty and the boundaries of judicial authority, especially when decisions extend beyond the parties’ claims and risk violating the ultra petita doctrine. This article examines the application of ex aequo et bono in Indonesian labor courts through a normative legal analysis, using both comparative and conceptual approaches. A focal point of the study is Supreme Court Decision No. 223 …

Ghosts At The Gate: A Call For Vigilance Against Ai-Generated Case Hallucinations, Christina Frohock

Articles

No abstract provided.

Julien Grisonas Family V. Argentina, Kamila Knaudt

Loyola of Los Angeles International and Comparative Law Review

This case is about the forced disappearance and murder of a Uruguayan artist and member of the Party for the Victory of the People and his wife by Argentina within the framework of Operation Condor. The case was brought by their children, who had been separated from their parents when they were taken and given up for adoption in Chile. Eventually, the Court found Argentina in violation of several articles of the American Convention but did not find a violation of the Inter-American Convention on Forced Disappearance of Persons.

Vibrissae-Inspired Vision-Based Magnetic-Actuated Whisker, Zhixian Hu, Yi Cheng, Juan P. Wachs, Yu She

School of Industrial Engineering Faculty Publications

Tactile perception is significant for robotic operation in unstructured environments. Whisker-based sensors offer lightweight bio-inspired solutions, yet most rely on single-whisker sensing and are limited by passive interaction and constrained functionality. Here we present a circular array of eight independently actuated whiskers, each driven by a pulse-switchable permanent magnet and tracked by a camera. This design enables simultaneous multi-point sensing and coordinated actuation, supporting diverse functions. Quantitative analyses demonstrate accurate pixel-to-physical mapping, consistent pixel-to-force characterization, and long-term repeatability. In this work, we show that an vibrissae-inspired vision-based magnetic-actuated whisker array integrating distributed perception with active interaction achieves reliable physical mapping, …

Sexual And Bystander Harassment Among Part-Time Employees: Effects On Work Attitudes, Stress, And Withdrawal, Robert T. Hitlan

Faculty Publications

This study investigated the impact of sexual and bystander harassment experiences on work attitudes, stress, withdrawal, and psychological well-being of part-time employees. Participants included 314 female employees who worked part-time in their organizations. All participants completed a computer-administered workplace experience survey assessing various aspects of their work environment, including personal and bystander harassment experiences, work-related attitudes (supervisor satisfaction, coworker satisfaction, and general job stress), work behaviors (work and job withdrawal), and psychological well-being. Experiences of sexual harassment and bystander harassment were predicted to be negatively related to satisfaction and psychological health and positively related to stress and withdrawal. Both forms …

Standing Before The Icj: A Novel Framework For Erga Omnes Partes, Elson Law

Loyola of Los Angeles International and Comparative Law Review

This paper explores the concept of legal standing before the International Court of Justice (“ICJ” or “the Court”) in contentious cases and the legal theories that states may invoke to establish their entitlement to submit claims relating to specific subject matters. The concept of standing in international law requires a party to demonstrate a sufficient legal interest in the subject matter of their case. Three primary theories potentially provide such an interest for states parties to multilateral treaties: legal injury from the respondent state’s violation of an obligation owed to the applicant state, obligations erga omnes partes created by the …

Society For Immunotherapy Of Cancer: Standards For Reporting Of Multiplex Immunohistochemistry/Immunofluorescence Assays (Stormi), Sam Sater, Carlo B Bifulco, Jaime Rodriguez-Canales, Joe Yeong, Guray Akturk, Michael Angelo, Carmen Ballesteros-Merino, Peter Bankhead, Subham Basu, Jorge M Blando, Saska Brajkovic, Marco Cassano, Benjamin J Chen, Ahmet F Coskun, Tricia R Cottrell, Carlos E De Andrea, Robin H Edwards, Colt Egelston, Logan L Engle, Marc S Ernstoff, Rong Fan, Michael Feldman, Bernard A Fox, Jerome Galon, Robyn Gartrell, Sacha Gnjatic, Benjamin F Green, James L Gulley, Anne Hellebust, Stephen Hewitt, Travis J Hollmann, Lucas A Horn, William J Howat, Clifford C Hoyt, Shawn M Jensen, Arutha Kulasinghe, Wiem Lassoued, Steven Lott, James Mansfield, Sebastian Marwitz, George Netto, David B Page, Edwin Parra, David L Rimm, Scott J Rodig, Roberto Salgado, Denis Schapiro, Kurt A Schalper, Joel C Sunshine, Michael J Surace, Alexander S Szalay, Magdalena Thurin, Jose C Villasboas, Keith Wharton, Ignacio I Wistuba, Jennifer H Yearley, Yinyin Yuan, Geroge Zaki, James Ziai, Janis M Taube

Faculty, Staff and Student Publications

Multiplex immunofluorescence and immunohistochemistry (mIF/IHC) are increasingly employed antibody-based technologies that use tissue sparingly and facilitate the detection of co-localized or neighboring biomarkers. Specifically, these platforms enable spatial analyses of the tumor microenvironment as well as extended applications, for example, describing normal tissue anatomy, autoimmunity, infectious diseases, etc. mIF/IHC has greatly enhanced biomarker discovery efforts, and a growing number of studies suggest superiority to traditional IHC. Standardization of staining approaches, reporting of image analysis strategies and resultant data is critical for facilitating cross-study comparisons, validation, deployment, and generalization of findings. To address this challenge, The Society for Immunotherapy of Cancer …