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Enhancing Crime Detection In Video Surveillance Via A Lightweight Blockchain And Homomorphic Encryption-Based Computer Vision System, Tanya Abdulsattar Jaber Jan 2025

Enhancing Crime Detection In Video Surveillance Via A Lightweight Blockchain And Homomorphic Encryption-Based Computer Vision System, Tanya Abdulsattar Jaber

Mesopotamian Journal of CyberSecurity

Blockchain technology consists of distributed ledgers or database systems, regarded as immutable, secure, and innovative, characterized by unsupervised internal maintenance with a special security protocol used to prevent inference from malicious or third parties. The widespread use of this technology has led to deep research into the problems posed by this technology, which can be summarized in terms of computational cost and latency time. The crime detection process in video surveillance has made great progress with the use of technologies such as the Internet of Things and blockchain technologies. However, to reach high levels of security in the physical crime …


Improved Blockchain Technique Based On Modified Slim Algorithm For Cyber Security, Sarah Mohammed Shareef, Rehab Flaih Hassan Jan 2025

Improved Blockchain Technique Based On Modified Slim Algorithm For Cyber Security, Sarah Mohammed Shareef, Rehab Flaih Hassan

Mesopotamian Journal of CyberSecurity

The number of cybersecurity incidents is increasing, and the cost of a security breach has a catastrophic financial effect. The existing real estate information systems require more robust and resilient cybersecurity solutions to secure hardware, software, and databases. Cybersecurity often relies on user behavior. Phishing attacks and social engineering can bypass blockchain security, highlighting the need for robust user education and awareness. Many blockchain networks face challenges in handling a high volume of transactions. Solutions that work well on a small scale may not perform efficiently as the network grows, leading to delays and increased costs. A secure system is …


Enhanced Audio Encryption Scheme: Integrating Blowfish, Hmac-Sha256, And Md5 For Secure Communication, Jenan Ayad, Noor Qaddoori, Hasanain Maytham Jan 2025

Enhanced Audio Encryption Scheme: Integrating Blowfish, Hmac-Sha256, And Md5 For Secure Communication, Jenan Ayad, Noor Qaddoori, Hasanain Maytham

Mesopotamian Journal of CyberSecurity

In today's communications, it is vital to protect audio data privacy before and after transfer. This work therefore introduces the enhanced audio encryption scheme (EAES), which employs the most effective techniques of cryptography and processes them to make it impossible for unauthorized persons or programs to access or change the contents of audio files. This method uses RSA to encrypt the Blowfish key, which is used for data encryption, the HMAC-SHA256 algorithm for integrity checks, and the Message-Digest algorithm (MD5) for the checking phase. The performance of the EAES is measured statistically via the MSE, PSNR, and correlation coefficient. For …


Smartphone Authentication Based On 3d Touch Sensor And Finger Locations On Touchscreens Via Decision-Making Techniques, Moceheb Lazam Shuwandy, Rawan Adel Fawzi Alsharida, Maytham M. Hammood Jan 2025

Smartphone Authentication Based On 3d Touch Sensor And Finger Locations On Touchscreens Via Decision-Making Techniques, Moceheb Lazam Shuwandy, Rawan Adel Fawzi Alsharida, Maytham M. Hammood

Mesopotamian Journal of CyberSecurity

Smartphone authentication systems must balance security and user convenience, which is a persistent challenge in the digital realm. Traditional biometrics, such as fingerprints and facial recognition, face vulnerabilities to spoofing and environmental conditions, limiting reliability. This study introduces a novel approach by integrating three-dimensional (3D) touch sensors with finger location data for authentication. The goal is to develop a system that improves accuracy while minimizing false positives and negatives, leveraging touch pressure and spatial interaction as unique biometric identifiers. Data from 20 participants, including pressure levels, spatial coordinates, and timestamps, were analysed using Random Forest (RF) and Extreme Gradient Boosting …


Enhancing Cybersecurity With Machine Learning: A Hybrid Approach For Anomaly Detection And Threat Prediction, Adil M. Salman, Bashar Talib Al-Nuaimi, Alhumaima Ali Subhi, Hussein Alkattan, Hussein Alkattan Jan 2025

Enhancing Cybersecurity With Machine Learning: A Hybrid Approach For Anomaly Detection And Threat Prediction, Adil M. Salman, Bashar Talib Al-Nuaimi, Alhumaima Ali Subhi, Hussein Alkattan, Hussein Alkattan

Mesopotamian Journal of CyberSecurity

In today's digital era, cybersecurity has become a principal concern because of the increasing frequency and advancement of cyber threats. This study explores machine learning models for detecting and predicting anomalies in cybersecurity datasets. The research evaluates models such as linear regression, decision tree, RF, gradient boosting, KNN, SVR, LSTM, and neural networks utilizing performance metrics such as accuracy, MAE and MSE. A hybrid model that integrates different learning strategies is additionally proposed to improve the predictive accuracy and strength. The results highlight the superiority of ensemble approaches, especially the hybrid model, in improving peculiarity detection capabilities. The comparative analysis …


Enhancing Traffic Data Security In Smart Cities Using Optimized Quantum-Based Digital Signatures And Privacy-Preserving Techniques, Tuqa Ghani Tregi, Mishall Al-Zubaidie Jan 2025

Enhancing Traffic Data Security In Smart Cities Using Optimized Quantum-Based Digital Signatures And Privacy-Preserving Techniques, Tuqa Ghani Tregi, Mishall Al-Zubaidie

Mesopotamian Journal of CyberSecurity

Securing big data in power plants is an important and fundamental step in the infrastructure of smart cities. In addition, it becomes a barrier if it is not controlled from the beginning. Security must be a combination of fast and robust properties. This research presents a traffic security system (TSS) in a smart city (SC). It is a novel paradigm meant to improve data security and integrity by means of a multilayered method. Advanced fault analysis, dual-stage pseudonymizing, quantum key distribution via the BB84 protocol, and Falcon signatures (FS) are combined in the proposed system. TSS enhances data security by …


The Equitability Of Virtual Public High School Education In Urban School District, Carissa Jury Jan 2025

The Equitability Of Virtual Public High School Education In Urban School District, Carissa Jury

Murray State Theses and Dissertations

Virtual education has become an integral component of modern high school education, particularly in urban districts where diverse student populations require flexible and equitable learning environments. This qualitative study explores the equitability of virtual public high school education in an urban school district, focusing on accessibility, student experiences, and policy implications. Using social constructivism and ecological systems' theory as theoretical frameworks, this research investigates factors influencing equitable outcomes, including access to technology, teacher and community support, and socioeconomic status. Data was collected through structured interviews and focus groups with students and parents engaged in virtual education. Key findings indicate that …


Spatial Analysis Of American Chestnut (Castanea Dentata) Distribution And Ecology In Kentucky’S Federal Lands, Jacob Raymond Pease Jan 2025

Spatial Analysis Of American Chestnut (Castanea Dentata) Distribution And Ecology In Kentucky’S Federal Lands, Jacob Raymond Pease

Murray State Theses and Dissertations

Anthropogenic factors have been the cause of the decline of tree species across the globe. From unsustainable logging and development to disease and improper management, threats to forests have taken their toll. The American chestnut (Castanea dentata) was once an integral basal tree species in Appalachian forests, but chestnut blight drove the species to functional extinction by the mid-1900s. The recent creation of genetically modified chestnuts gives hope for future restoration of the species throughout its historical range. Despite blight resistance, effective restoration will require optimal site selection for finding and planting chestnuts, which will maximize limited resources. …


The Link Between Poor Student Reading Proficiency And College And Career Readiness, James D. Kirkland Iii Jan 2025

The Link Between Poor Student Reading Proficiency And College And Career Readiness, James D. Kirkland Iii

Murray State Theses and Dissertations

The ability to read proficiently is a skill often considered necessary for the success of an individual while in school and after graduating from high school. Although reading proficiency plays a large role in an individual's success, many students in our nation’s schools struggle to read and comprehend the texts they are presented with in their academic courses. The purpose of this research study was to determine whether a link existed between the reading proficiency and college and career readiness of high school agriculture students. The study used a mixed methods approach that collected both qualitative and quantitative data to …


Teachers Stay And Go: The Impacts Of Agriculture Education Teacher Retention In Georgia, Alisha Richardson, Kristie Guffey Jan 2025

Teachers Stay And Go: The Impacts Of Agriculture Education Teacher Retention In Georgia, Alisha Richardson, Kristie Guffey

Murray State Theses and Dissertations

Agricultural education teachers are vital in shaping students' academic and social development while supporting Georgia’s largest economic sector. Despite their importance, the retention of qualified agriculture teachers has remained a persistent challenge since the 1970s (Camp, 1995). This study examined the factors influencing teacher retention in Georgia’s agricultural education programs, to identify actionable strategies to reduce attrition. Findings revealed that supportive workplace environments, strong student relationships, professional learning communities, and mentorship opportunities are key motivators for teacher longevity. Financial incentives and targeted professional development emerged as effective retention tools (Guffey & Young, 2020). In contrast, high levels of stress, particularly …


The Representation Of Feminine Beauty In Generative Artificial Intelligence Models, Haley R. Stacy Jan 2025

The Representation Of Feminine Beauty In Generative Artificial Intelligence Models, Haley R. Stacy

Murray State Theses and Dissertations

As Artificial Intelligence (AI) technology advances, its influence on media and societal perceptions becomes increasingly significant. This dissertation explores how popular generative visual AI models represent women and the implications for racial and body type inclusivity. This study examines women’s perceptions of AI-generated representations. Two primary research questions are being explored: (1) How do AI-generated algorithms represent women in visual outputs when prompted with broad beauty-related keywords? (2) How do women perceive their representation in these AI-generated visual outputs? Through a detailed analysis of AI-generated imagery, the research uncovers implicit and explicit biases within these systems. The research also gathered …


Managing Campus Dissent: An Assessment Of University Responses To Pro-Palestinian Protests, Kathryn S. Walker Jan 2025

Managing Campus Dissent: An Assessment Of University Responses To Pro-Palestinian Protests, Kathryn S. Walker

Murray State Theses and Dissertations

University leaders face challenges navigating student dissent and effectively upholding free speech while encouraging students to view the world from a new perspective. Higher education institutions employ a variety of strategies to handle campus crises and mitigate negative perceptions that may arise. This qualitative research study provides insight into the crisis communication strategies employed by university administrators at ten institutions with the highest number of pro-Palestinian protest days from October 7, 2023, to May 29, 2024, through the analysis of university statements and student newspaper responses. Campus leaders found themselves in a challenging position, unable to satisfy all constituencies. Each …


The Impact Of The Implementation Of The Interconnected Systems Framework (Isf) On Educators, Kayla Jones Jan 2025

The Impact Of The Implementation Of The Interconnected Systems Framework (Isf) On Educators, Kayla Jones

Murray State Theses and Dissertations

Amid growing concerns around teacher retention and educator job satisfaction, this study explored how system-level frameworks, particularly the Interconnected System Framework (ISF), could influence key teacher outcomes. While the ISF has been widely associated with improved student outcomes, this research investigated its potential to enhance educator experiences, focusing on working conditions, retention rates, and school climate. Quantitative analysis revealed that schools implementing the ISF or PBIS reported significantly more favorable working conditions and school climate compared to non-implementing schools. Although teacher retention rates did not significantly differ across implementation types, notable variability within the non-implementing group suggests a need for …


The Evolution Of Veterinary Technology Education: Growth, Accreditation, And The Role Of Murray State University’S Veterinary Technology Program, Tara Joiner Jan 2025

The Evolution Of Veterinary Technology Education: Growth, Accreditation, And The Role Of Murray State University’S Veterinary Technology Program, Tara Joiner

Murray State Theses and Dissertations

This dissertation examines the evolution of veterinary technology education, focusing on the growth, accreditation, and role of Murray State University’s (MSU) veterinary technology program. The veterinary profession has experienced significant advancement and expansion in recent years. The American Veterinary Medical Association (AVMA) accredits veterinary technology programs, setting standards and conducting reviews to ensure quality. Murray State University’s veterinary technology program, accredited by the AVMA in 1986, prepares students for the Veterinary Technology National Exam (VTNE) through a comprehensive curriculum and internships (practical experience). Findings from a three-year period (2022–2024) highlight mentor confidence in student readiness at 77.3%, with qualitative feedback …


Examining Kentucky Agriculture Teachers’ Use Of Student Credentialing In Agricultural Education Programming, Kaycee J. Palmeri, Kevin T. Wells Jan 2025

Examining Kentucky Agriculture Teachers’ Use Of Student Credentialing In Agricultural Education Programming, Kaycee J. Palmeri, Kevin T. Wells

Murray State Theses and Dissertations

The purpose of this qualitative study was to explore Kentucky agriculture teachers’ perceptions regarding current industry credential offerings, how they operationalize the curricula, knowledge, and skills necessary to prepare for industry credential offerings, and the perceived benefits for students who earn such credentials. The current study was undergirded by human capital theory. Using random sampling across the 12 Kentucky FFA service regions, the researcher collected data from nine current Kentucky agriculture teachers via semi-structured interviews. Further, the researcher used a Qualtrics-based instrument to collect participant demographics data. The analysis of the interview data revealed eight distinct emerging themes. The researcher …


Too Much Information: The Role Everyday Information Plays In The Understanding Of Mental Health, Jeremy M. Morgan Jan 2025

Too Much Information: The Role Everyday Information Plays In The Understanding Of Mental Health, Jeremy M. Morgan

Murray State Theses and Dissertations

Information overload has become increasingly problematic within the world of mental health, as people are able to go online and access overwhelming amounts of mental health-related information within seconds. The aim of the current study was to examine the interaction between excess mental health information and individuals’ understanding of mental health, specifically Autism Spectrum Disorder (ASD), as well as self-diagnosis. Data from 128 participants was examined. The data collected related to participants’ online search and use patterns of ASD information, their understanding of ASD symptoms, as well as their experiences with those symptoms. Results indicated a significant positive correlation between …


Bridging Classroom And Competition: How Students With Intellectual Disabilities Learn And Apply Ffa-Related Skills, Skyler Lempert Jan 2025

Bridging Classroom And Competition: How Students With Intellectual Disabilities Learn And Apply Ffa-Related Skills, Skyler Lempert

Murray State Theses and Dissertations

Though people often hear about inclusion and differentiation in education and their classroom settings there are questions about the capability and effectiveness of students with moderate to severe disabilities to participate in intra-curricular activities such as the National FFA Organization. Often teachers are tasked with trying to find ways for students to be a part of these experiences with little education on this aspect. This research begins by examining the historical progress of special education, particularly in relation to students with moderate to severe disabilities. It then explores the complex educational needs of this population and how schools have worked …


Dirty Water, Breanna Booker, Michael S. Sinha Jan 2025

Dirty Water, Breanna Booker, Michael S. Sinha

All Faculty Scholarship

Plastics are taking over. Every day, humans are exposed to plastic pollutants in a variety of ways. From the water we use to water crops in the field, to the water in our taps, to the liquids we drink from plastic containers, it can be found virtually anywhere you look. Not only is it everywhere in the environment, but it is also within us. It builds up in our bodies. Plastics have become a major public health concern; researchers estimate that the total healthcare cost related to plastic chemicals may be as much as $250 billion.[1]

Water has always …


An Indecent Exposure Of The Rules Of Legal Ethics, Lauren E. Bartlett Jan 2025

An Indecent Exposure Of The Rules Of Legal Ethics, Lauren E. Bartlett

All Faculty Scholarship

Thousands of attorneys experience rape and sexual assault by clients, as well as indecent exposure, public masturbation, unwanted touching, verbal threats, and stalking. These incidents are not often publicly reported, but client sexual violence against attorneys is not uncommon. The ethical rules currently fail to account for an attorney who has experienced client sexual violence, whether to allow for termination of representation or to mitigate future harm to other lawyers. While the ethical rules are usually thought of as neutral, this Article critically examines the gender stereotypes and structures of oppression corseting the rules. Relying on a fifty-state survey of …


Managing Compliance: The Role Of Leadership Styles In Information Security Practices In Nigerian Public University Libraries” Insights From North-East Nigeria, Musa Giade Ya'u Musagiade, Gaberial O. Alegbeleye, Madukoma Ezinwanyi Jan 2025

Managing Compliance: The Role Of Leadership Styles In Information Security Practices In Nigerian Public University Libraries” Insights From North-East Nigeria, Musa Giade Ya'u Musagiade, Gaberial O. Alegbeleye, Madukoma Ezinwanyi

Library Philosophy and Practice (e-journal)

Background: Information security compliance comprises adhering to established policies, protocols and to ensure absolute security. Despite the importance of security compliance in academic libraries, evidence from previous studies reported a low level of information security compliance among personnel in public university libraries in North-East Nigeria. However, proper leadership styles influence information security compliance leading to absolute protection of information systems. So, this study explored the influences of leadership styles in security compliance in public university libraries in North-East, Nigeria.

Method: This study adopted a survey research design. The population consisted of 618 library personnel from the 14 public university libraries …


Evaluating And Supporting Leadership, Management, And Mentoring: A Framework For Catalyzing Responsible Research And Healthy Research Environments, Tristan Mcintosh, Alison L Antes Jan 2025

Evaluating And Supporting Leadership, Management, And Mentoring: A Framework For Catalyzing Responsible Research And Healthy Research Environments, Tristan Mcintosh, Alison L Antes

2020-Current year OA Pubs

Those who lead research teams have myriad roles and responsibilities that are pivotal to both producing rigorous and responsible scientific work and creating a supportive research environment that cultivates this work. We begin by presenting a leadership, management, and mentoring (LMM) framework focused on three critical roles researchers must play that have direct impact on the scientific work, the work environment, and research team dynamics: the role of research leader, research manager, and research mentor. Research leadership involves fostering a healthy research culture by building relationships where team members feel respected and supported. Research management involves providing oversight and direction …


Multisensory Naturalistic Decoding With High-Density Diffuse Optical Tomography, Kalyan Tripathy, Zachary E Markow, Morgan Fogarty, Mariel L Schroeder, Alexa M Svoboda, Adam T Eggebrecht, Bradley L Schlaggar, Jason W Trobaugh, Joseph P Culver Jan 2025

Multisensory Naturalistic Decoding With High-Density Diffuse Optical Tomography, Kalyan Tripathy, Zachary E Markow, Morgan Fogarty, Mariel L Schroeder, Alexa M Svoboda, Adam T Eggebrecht, Bradley L Schlaggar, Jason W Trobaugh, Joseph P Culver

2020-Current year OA Pubs

SIGNIFICANCE: Decoding naturalistic content from brain activity has important neuroscience and clinical implications. Information about visual scenes and intelligible speech has been decoded from cortical activity using functional magnetic resonance imaging (fMRI) and electrocorticography, but widespread applications are limited by the logistics of these technologies.

AIM: High-density diffuse optical tomography (HD-DOT) offers image quality approaching that of fMRI but with the silent, open scanning environment afforded by optical methods, thus opening the door to more naturalistic research and applications. Although early visual decoding studies with HD-DOT have been promising, decoding of naturalistic auditory and multisensory stimulus information from HD-DOT data …


Zika Virus Encephalitis Causes Transient Reduction Of Functional Cortical Connectivity, Shannon C Agner, Lindsey M Brier, Jeremy D Hill, Ethan Y Liu, Annie Bice, Rachel M Rahn, Shengxuan Chen, Joseph P Culver, Robyn S Klein Jan 2025

Zika Virus Encephalitis Causes Transient Reduction Of Functional Cortical Connectivity, Shannon C Agner, Lindsey M Brier, Jeremy D Hill, Ethan Y Liu, Annie Bice, Rachel M Rahn, Shengxuan Chen, Joseph P Culver, Robyn S Klein

2020-Current year OA Pubs

SIGNIFICANCE: Determining the long-term cognitive impact of infections is clinically challenging. Using functional cortical connectivity, we demonstrate that interhemispheric cortical connectivity is decreased in individuals with acute Zika virus (ZIKV) encephalitis. This correlates with decreased presynaptic terminals in the somatosensory cortex. During recovery from ZIKV infection, presynaptic terminals recover, which is associated with recovered interhemispheric connectivity. This supports the contribution of synapses in the cortex to functional networks in the brain, which can be detected by widefield optical imaging. Although myeloid cell and astrocyte numbers are still increased during recovery, RNA transcription of multiple proinflammatory cytokines that increase during acute …


Baseline Clinical Characterization Of Participants In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al. Jan 2025

Baseline Clinical Characterization Of Participants In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al.

2020-Current year OA Pubs

BACKGROUND: This paper focuses on the baseline clinical characterization of the participants in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program. The AMP SCZ program is designed to investigate a wide array of clinical variables and biomarkers in a total of 2040 clinical high-risk (CHR) participants and 652 community control (CC) participants.

METHODS: The dataset analyzed includes 1642 individuals at clinical high risk for psychosis and 519 CCs. Key measures include the Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the Structured Interview for Psychosis-Risk Syndromes, which determined CHR criteria and the severity …


Sample Ascertainment And Recruitment Sources In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al. Jan 2025

Sample Ascertainment And Recruitment Sources In The Accelerating Medicines Partnership Schizophrenia Program, Jean Addington, Daniel Mamah, Et Al.

2020-Current year OA Pubs

BACKGROUND: This paper presents the recruitment sources of clinical high-risk (CHR) and community controls (CC) from the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program, which aims to study various clinical variables and biomarkers in 2040 CHR and 652 CC participants.

METHODS: A total of 1640 CHR and 514 CC had recruitment source data. The Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the SIPS was utilized to assess CHR criteria and severity of attenuated psychotic symptoms (APSs), and the Global Functioning: Social Scale was used for social functioning. Participants were recruited through various …


An Explainable Ai Approach For Mapping Multivariate Regional Brain Age And Clinical Severity Patterns In Alzheimer's Disease, Gauri Darekar, Taslim Murad, Hui-Yuan Miao, Deepa S Thakuri, Alzheimer’S Disease Neuroimaging Initiative, Ganesh B Chand Jan 2025

An Explainable Ai Approach For Mapping Multivariate Regional Brain Age And Clinical Severity Patterns In Alzheimer's Disease, Gauri Darekar, Taslim Murad, Hui-Yuan Miao, Deepa S Thakuri, Alzheimer’S Disease Neuroimaging Initiative, Ganesh B Chand

2020-Current year OA Pubs

Age is a significant risk factor for mild cognitive impairment (MCI) and Alzheimer's disease (AD) and identifying brain age patterns is critical for comprehending the normal aging and MCI/AD processes. Prior studies have widely established the univariate relationships between brain regions and age, while multivariate associations remain largely unexplored. Herein, various artificial intelligence (AI) models were used to perform brain age prediction using an MRI dataset (


Phase I Study Of Nt-I7, A Long-Acting Interleukin-7, In Severe Treatment-Related Lymphopenia Following Standard Radiation And Temozolomide For High-Grade Glioma, Jian L Campian, Milan G Chheda, John F Dipersio, Et Al. Jan 2025

Phase I Study Of Nt-I7, A Long-Acting Interleukin-7, In Severe Treatment-Related Lymphopenia Following Standard Radiation And Temozolomide For High-Grade Glioma, Jian L Campian, Milan G Chheda, John F Dipersio, Et Al.

2020-Current year OA Pubs

BACKGROUND: High-grade gliomas (HGG) have a poor prognosis despite aggressive treatment. Severe, persistent lymphopenia occurring in HGG patients after concurrent chemoradiation is associated with worse survival. NT-I7, a long-acting interleukin-7 analog, has been shown to increase CD4 and CD8 counts in healthy, septic, and HIV-positive adults. This multi-institutional, NCI-funded dose-escalation trial is the first to evaluate NT-I7 safety and activity in HGG patients with severe treatment-related lymphopenia (TRL) and the effect of co-administered glucocorticoids.

METHODS: Eligible HGG patients had CD4 counts < 300 cells/mm

RESULTS: NT-I7 was well tolerated in all 12 patients (median age 64; median CD4 count 161 cells/mm³) before the …


Recombinant Human Alpha-N-Acetylglucosamine-6-Sulfatase Delivered To Sanfilippo D Mice With Repeated Intracerebroventricular Injections Corrects Cns Pathology, Grant L. Austin, Feng Wang, Steven Q. Le, Alexander Sorensen, Shan Li, Lai C. Foong, Srikanth Singamsetty, Jill Wood, Tsui-Fen Chou, Patricia I. Dickson Jan 2025

Recombinant Human Alpha-N-Acetylglucosamine-6-Sulfatase Delivered To Sanfilippo D Mice With Repeated Intracerebroventricular Injections Corrects Cns Pathology, Grant L. Austin, Feng Wang, Steven Q. Le, Alexander Sorensen, Shan Li, Lai C. Foong, Srikanth Singamsetty, Jill Wood, Tsui-Fen Chou, Patricia I. Dickson

2020-Current year OA Pubs

Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo D) is caused by biallelic pathogenic variants in N-acetylglucosamine-6-sulfatase (GNS), which participates in catabolism of heparan sulfate (HS) glycosaminoglycans. Characterization of MPS IIID disease at a cellular level has not been robustly achieved. We used unbiased quantitative proteomics to establish a cellular phenotype for MPS IIID mice. Recombinant human GNS (rhGNS), a variant of which previously demonstrated single dose efficacy in MPS IIID human fibroblasts and in MPS IIID neonatal mice, was used to establish a repeat dosing schedule to treat MPS IIID mice. Adult Gns KO mice or heterozygous carriers were treated via …


Thalamic And Visual Network Dysfunction Relates To Tremor Response In Thalamic Deep Brain Stimulation, Aimee E Morris, Babatunde Adeyemo, Meghan C Campbell, Abraham Z Snyder, Joel S Perlmutter, Jonathan W Mink, Scott A Norris Jan 2025

Thalamic And Visual Network Dysfunction Relates To Tremor Response In Thalamic Deep Brain Stimulation, Aimee E Morris, Babatunde Adeyemo, Meghan C Campbell, Abraham Z Snyder, Joel S Perlmutter, Jonathan W Mink, Scott A Norris

2020-Current year OA Pubs

BACKGROUND: Essential tremor (ET) is the most common movement disorder in adults, but its pathogenesis is incompletely understood. Deep brain stimulation of the ventral intermediate thalamic nucleus (VIM DBS) provides effective treatment for medically-refractory cases. We aimed to determine how pre-surgical resting-state functional connectivity (FC) in medically-refractory ET relates to VIM DBS clinical response.

METHODS: We analyzed resting-state FC MRI in 21 participants with medically-refractory ET who subsequently underwent VIM DBS and 34 matched controls. We applied rigorous quality assurance to minimize motion artifact. Whole-brain correlation matrices were computed across 300 cortical, subcortical, and cerebellar regions and compared across groups …


Comparison And Clinical Applicability Analysis Of All-Posterior, Combined Anterior-Posterior, And Combined Lateral-Posterior Approaches In Adult Spinal Deformities: A Narrative Review, Garrison P. Bentz, Christopher Diaz, Nicholas A. Pollatta, Mark J. Lambrechts Jan 2025

Comparison And Clinical Applicability Analysis Of All-Posterior, Combined Anterior-Posterior, And Combined Lateral-Posterior Approaches In Adult Spinal Deformities: A Narrative Review, Garrison P. Bentz, Christopher Diaz, Nicholas A. Pollatta, Mark J. Lambrechts

2020-Current year OA Pubs

No abstract provided.