Digital Commons Network^™

Targeted Coaching In The Detroit Promise Path: A Thematic Network Analysis Of Current Challenges And Opportunities For Student Success, Maryse Danielle Wilson

Theses and Dissertations

The Detroit Promise Program is one of the many college promise programs operating within the United States that offers full college tuition coverage to students within the city who meet certain residential criteria. Detroit’s population has one of the highest proportions of Black and first-generation students and the lowest average socioeconomic class in the country. From the time of the Promise Program’s launch until now it has seen minor improvements in college degree competition rates, but this rate is still low compared to the national average. The Detroit Promise Path, which is an off branch of the Detroit Promise Program, …

Food Waste Renaissance: From The Table, For The Table, Yasamin Shaikhi

Theses and Dissertations

What if waste could be seen as a valuable resource rather than a burden? Food Waste Renaissance (FWR) explores innovative ways to transform excess food and byproducts into sustainable design materials. In Qatar, where food waste constitutes approximately 60% of urban waste, FWR promotes a shift in perception rather than attempting to resolve large-scale waste management issues. By fostering a culture where surplus becomes a resource, it inspires individuals, designers, and communities to embrace and contribute to a circular economy. FWR examines rice and date byproducts as biodegradable raw materials for lamps, bringing material from the table back to the …

Strength Imbalances And Shoulder Pain In Manual Wheelchair Users Stratified By Age Of Spinal Cord Injury/Disorder (Sci/D) Onset, Ashlyn M. Jones

Theses and Dissertations

Introduction The majority of manual wheelchair users (MWUs) with spinal cord injury or disorder (SCI/D) develop shoulder pain. In adults with SCI/D, there is evidence that upper limb strength imbalances are associated with shoulder pain. However, strength imbalances may indicate protective compensatory strategies, and other factors may be important contributors to pain. Currently, personalized prevention and management of pain is limited, little is known about joint strength imbalances and pain in children who use manual wheelchairs, and the effect of the age of SCI/D onset is poorly understood. The purpose of this study was to assess the effect of age …

Reply Stop To Stop, Molly A. M. Garrett

Theses and Dissertations

Over the course of 8 years working in progressive political strategy, 2015–2023, I became increasingly critical of the systems, formulas and tools we were using to communicate with voters. Reply STOP to Stop is documentation of my time at graduate school, of wrestling with ideas of political design, language, communication and distribution. I analyzed my past work — all the texts, emails, social media posts, print ads, web banners, videos and other miscellaneous scripted content — and wondered if we would all be better off without it. Would elections be fairer, would there be less fake news, more community building? …

Watchpeopledie . Tv, Noah Lebien

Theses and Dissertations

The thesis piece is a performance called watchpeopledie.tv performed four times at the Anderson Gallery in the Hidden Galleries. There are two rooms in the gallery. The first room is where the audience enters. There is a line on the floor marking that the audience is not to move further into the first room or into the second room. The audio consists of verbatim comments sourced from videos of violence against trans people from the website watchpeopledie.tv, a website in which users post real videos of shootings, suicides, car accidents, etc. The main text, which is my thesis writing below, …

Mementos, Zixuan Guo

Theses and Dissertations

Relevance:

Personal Relevance: This project merges my passion for film photography and modern technology, aiming to create a design that bridges traditional and modern practices.

Local Relevance: Richmond’s rich historical context provides an ideal setting to illystrate that traditional arts like analog photography can be preserved while integrating modern digital technology.

Global Relevance: Globally, there is an increasing trend toward combining traditional and modern design approaches, particularly in architecture and interior design. Synthesizing analog and digital means is used to meet the balance between materiality and modern technology (Rose, 2014; Pelizzari & Scrivano, 2011). Designers balance tactile materials like wood …

Enhancing Clinical Trial Matching In Molecular Diagnostics: Using Natural Language Processing And Clustering Approaches In Hematological Malignancies, Gillian Fanning

Theses and Dissertations

Clinical trial matching is a critical component of personalized medicine, particularly in the management of hematologic malignancies. At Virginia Commonwealth University (VCU) Health, the Molecular Diagnostics (MDX) Lab produces somatic variant reports and recommends clinical trials based on the presence of clinically significant mutations. However, the current manual trial recommendation process is time-intensive and lacks scalability.

This study introduces a computational framework to streamline and standardize clinical trial matching using natural language processing (NLP) and unsupervised clustering. Trial brief descriptions were analyzed to extract frequent terms, and trials were grouped based on term similarity using joint dimensionality reduction and clustering. …

Developing Bioinformatics Expertise Through The Annotation Of The Gut Microbiome Of Odontotaenius Disjunctus, Keidra E. Carter

Theses and Dissertations

Next-generation sequencing (NGS) technologies have revolutionized biological research by generating unprecedented volumes of genomic data, necessitating advanced bioinformatics tools and specialized expertise to fully interpret complex microbial communities. This study outlines an integrated workflow to characterize the gut microbiome of the wood-feeding beetle Odontotaenius disjunctus. Prokka is employed for functional annotation to identify protein-coding genes and other genomic features, while Kaiju is used for taxonomic classification. DIAMOND is then applied to locate and validate the taxonomic assignments generated by Kaiju by aligning sequences within the contigs to a comprehensive protein database, proGenomes. Functional analysis revealed that the contigs encode proteins …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

Persistence Of Southwestern White Pine (Pinus Strobiformis) In An Ever-Changing Environment, Shruti Shrivastava

Theses and Dissertations

Abstract

Local adaptation is known to occur in multiple tree species, with climate as a main force for it occurring, indicating adaptation and changes occurring in spatially and temporally changing climates. With increased climate change, the question now is what future persistence may appear as, and by what magnitude trait mismatch may occur. This is observed in southwestern white pine (Pinus strobiformis) for drought-response traits: resistance (RT), recovery (RC), and resilience (RS). Using previously collected data, the genetic and phenotypic diversity were analyzed. Using that information, the trait values for individuals where only genetic data was known was …

Characterization Of Nanoplastic-Induced Exacerbation Of Asthmatic Pathophysiology In A Murine In Vivo Model, Keith Li

Theses and Dissertations

As global plastic production increases, so does the environmental and biological presence of nanoplastics (NPs), raising growing concerns about their potential impact on human health. These particles have been detected in various organs, including the lungs, yet their role in respiratory inflammation remains largely unexplored. Emerging evidence suggests that NP exposure may influence immune responses in the lungs, particularly in individuals with preexisting conditions such as asthma. However, the specific ways in which these particles interact with allergen driven inflammation are still unclear.

In this study, a murine model of allergic airway inflammation was used to investigate how surface modified …

Intervertebral Lateral Bending Moment Differences In The Lumbar Spine Of Baseball Pitchers Across Throwing Velocities, Justin Humenay

Theses and Dissertations

Introduction Baseball pitching imposes substantial mechanical demands on the lumbar spine, a crucial link in the kinetic chain responsible for transferring energy from the lower body to the upper extremity. While increased pitch velocity is associated with greater trunk forces the specific intervertebral loading patterns during high-velocity pitching remain unclear. This study investigates differences in lateral bending moments across lumbar spinal segments between collegiate pitchers throwing at high versus low velocities.

Methods Twenty right-handed collegiate pitchers were divided into two groups: high-velocity (n = 10, 90.3 ± 1.6 mph) and low-velocity (n = 10, 81.6 ± 1.1 mph). Motion capture …

Automated Treatment Planning Framework For Cervical Cancer In Brachytherapy, Suman Gautam

Theses and Dissertations

Brachytherapy (BT) is a critical treatment modality for cervical cancer that delivers ionizing radiation directly to the tumor using intracavitary (IC) and/or interstitial (IS) applicators. In high dose-rate (HDR) BT, a remote afterloader guides the radioactive source to specific dwell positions for defined durations, known as dwell times, allowing for a conformal dose to the tumor while minimizing exposure to surrounding organs at risk (OAR). However, due to the inherent nature of ionizing radiation, some dose to OARs is unavoidable, creating a fundamentally conflicting objective in treatment planning: maximizing tumor coverage while minimizing OAR dose. This characterizes the problem as …

Bugs In The Flux: Links Between Arthropod Diversity And Spatial Variation Of Soil Respiration In A Temperate Forest, Erin-Darby H. Mcclain

Theses and Dissertations

Soil respiration (Rs) is the largest terrestrial flux of carbon (C) to the atmosphere, with heterotrophic contributions to Rs varying spatially and temporally. While microbes are the primary and most thoroughly studied source of soil heterotrophic respiration (Rh), contributions from higher trophic organisms, including arthropods, are rarely quantified and poorly understood. Arthropod abundance and diversity correspond with variation in soil microclimate, which is influenced by site factors including canopy structure, site productivity, and disturbance. However, the extent to which these site factors influence arthropod abundance and diversity, and consequently, spatial variation in Rs is not known. The objective of our …

Advanced Air Preheater Sealing Systems For Enhanced Efficiency And Reliability In Thermal Power Plants, Pavan Kumar Ravulaparthy

Theses and Dissertations

Global electricity generation still relies heavily on thermal power plants, which consume vast amounts of fuel and emit significant amounts of carbon dioxide. A major but often overlooked source of inefficiency in these plants lies within the rotary regenerative air preheater (RAPH), a critical heat-exchange component where air leakage can exceed 20% in aging units. This leakage increases fuel consumption, parasitic fan power, and CO₂ emissions, while degrading boiler reliability.

This research introduces advanced adaptive sealing systems designed to mitigate these losses by dynamically compensating for rotor eccentricity, thermal distortion, and wear under harsh operating conditions. Brush seals, composed of …

Knowing By Heart: Philosophical Dimensions Of Humanistic Mathematics Education, Catherine Henney

Theses and Dissertations

This project seeks to revive interest in late twentieth century humanistic mathematics education (HME) so that its principles might cross the boundary of higher education and settle in corners of the K-12 math education space. In particular, HME’s theme of teaching math humanistically directs attention to features and phenomena that bear strongly on students’ daily classroom experiences. Personhood, agency, inquiry, meaning, environment, feelings, relationships: these elements invite a more thorough meditation and philosophical analysis. Though it is a largely philosophical endeavor, this project is enlivened by classroom vignettes and case studies that bring practical relevance to HME’s core principles. Chapters …

Scopolamine-Induced Modulation Of Serotonin And Dopamine Transporters Activity: Behavioral And Molecular Insights Into Rapid Antidepressant Action, Deepak Karunakaran

Theses and Dissertations

Major depressive disorder (MDD) affects over 350 million individuals worldwide and is characterized by profound dysregulation of serotonin (5-HT) and dopamine (DA) systems that govern mood, reward processing, and motivation. The serotonin transporter (SERT) and dopamine transporter (DAT), both dynamically regulated through phosphorylation, serve as critical determinants of synaptic monoamine signaling. Despite decades of therapeutic development, current antidepressants require 4-6 weeks to achieve efficacy, and approximately one-third to half of patients develop treatment-resistant depression. The emergence of rapid-acting antidepressants like ketamine represents a paradigmatic shift, demonstrating symptom relief within hours; however, ketamine's therapeutic potential remains constrained by abuse liability, dissociative …

Therapy-Induced Senescence In Cancer: Developing Senolytic-Based Combination Strategies To Delay Re-Emergence Of Triple-Negative Breast Cancer, Eesha Chakraborty

Theses and Dissertations

Therapy-induce senescence (TIS) represents a major biological outcome of many anticancer treatments and is increasingly recognized as a strategic vulnerability in triple negative breast cancer, which is a highly aggressive subtype with limited therapeutic options and frequent relapse. Here, we probed TIS as a primary cellular response that may ultimately compromise long-term outcomes using standard chemotherapeutic agents in TNBC as well as the antibody-drug conjugate sacituzumab govitecan (SG). Both chemotherapy and SG reliably induced pronounced senescence across TNBC models, yielding durable growth arrest, however, also generating a persistent reservoir of viable tumor cells capable of eventual proliferative recovery, a hallmark …

Financial Health Literacy Of Community-Dwelling Older Adults: A Qualitative Research Study, Kimberly Davis

Theses and Dissertations

Background: Financial health literacy (FHL) is an emerging concept with unique application to older adults. Multiple complexities converge in older age that create increased financial vulnerability (e.g., retirement, chronic disease). However, low financial and health literacy are common in older adults, impacting their ability to self-manage. The AWV’s focus on prevention offers an opportunity to incorporate a proactive approach to financial-related assessment. This study will explore the perceived value of assessing FHL in primary care settings and the financial-related barriers and facilitators to implementing the personalized prevention plan.

Methods: The conceptual framework was guided by the Individual and Family Self-Management …

The Role Of Context Sensitivity On The Association Between Racial Discrimination And Emotional Dysfunction Among Black American Adolescents, Summer C. Bryant

Theses and Dissertations

Black adolescents are at an increased risk of experiencing racial discrimination due to a developmental period marked by increased time away from parents and caregivers and increased time with peers (Fisher et al., 2000). Empirical research has shown that Black adolescents’ experiences of racial discrimination are associated with emotion dysfunction (Benner et al., 2018; Seaton et al., 2009; Sellers et al., 2006). Although previous research has identified racial factors such as racial socialization and racial identity as protective factors by reducing the impact of racial discrimination on Black adolescents’ emotion dysfunction (Gibson et al., 2021; Neblett et al., 2008), we …

Swarming Segregation: Leveraging Swarm Intelligence And Regionalization As Instruments For School District Desegregation, Jeffrey Wooten

Theses and Dissertations

Even after Brown led to the South briefly having the most diverse schools in the nation, schools throughout the Northeast have remained the most segregated in the nation for decades. While federal jurisprudence has made compelling desegregation pursuant to the Equal Protection Clause more challenging, New Jersey has a particularly favorable landscape to address severe segregation. With a highly diverse, densely populated public enrollment, favorable state constitutional precedent, and a history of successfully compelling desegregation, New Jersey is fertile ground exploring regional desegregation. Scholars, judges, and even plaintiffs in ongoing litigation (Latino Action Network v. N.J.) have called for New …

The Weapon Focus Effect On Memory For Male And Female Perpetrators, Faith Christel Aasen

Theses and Dissertations

Previous research on the weapon focus effect suggests that weapon presence causes reduced memory accuracy for perpetrator details due to weapons being surprising and unexpected. The unusualness hypothesis suggests that a stronger weapon focus effect should occur when the perpetrator defies typical gender stereotypes, such as a woman holding a gun. The current study sought to examine how the weapon focus effect impacts eyewitness memory for male and female perpetrators, specifically exploring the magnitude of the effect on female perpetrators. The current study further investigated whether the own gender bias attenuates the weapon focus effect on memory for female perpetrators. …

Comparative Analysis Of Lstm-Based And Traditional Hydrologic Models For River Discharge Prediction: A Case Study Of The Goose River, Adewale Ajao

Theses and Dissertations

Streamflow predictions are important in planning water resources and effective hydrological management. Physically based models such as the Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) have been used in the past for this purpose. Still, the use of machine learning models such as Long Short-Term Memory (LSTM) has been proven to complement the use of traditional models. This study compares the reliability performances of HEC-HMS and LSTM models to predict the streamflow of Goose River Watershed in North Dakota. The objective of the research is to perform a comprehensive comparative analysis between the performance of HEC-HMS and LSTM models to predict …

Hazard Impact Assessment Of Brine Spills On Groundwater Pollution In Western North Dakota, Grace Dzifa Agbozo

Theses and Dissertations

The rapid expansion of oil and gas production in North Dakota’s Bakken Formation has heightened environmental concerns, particularly groundwater contamination from brine spills. Brine, a highly saline byproduct of oil extraction, poses a serious threat to water quality due to its chemical composition. This study examines brine spill impacts from 2013 to 2024 across Williams, Mountrail, McKenzie, and Dunn counties using GIS and the DRASTIC model, enhanced with Analytical Hierarchy Process (AHP) and Fuzzy Overlay techniques. Essential hydrogeological factors were analyzed to produce vulnerability index maps. Furthermore, spatial autocorrelation (Moran’s I), Optimized Hot Spot Analysis, and Emerging Hot Spot Analysis …

Domain Adapted Signal Classification For Simulated And Real-World Signals, Mohammad Ali

Theses and Dissertations

Signal classification models based on deep neural networks are trained on a set of data either simulated or over-the-air that are restricted to specific channel environments, varying distortion conditions such as SNR offsets. The consequence are models that unexpectedly do not do well in scenarios when the feature distribution between domains are too large such as when simulated models are deployed in real world environments. In this regard, we propose signal classification framework leveraging Domain-Adversarial Neural Networks to address SNR variability for simulated data Unsupervised Domain Adaptation frameworks for simulated to real world signals. Our first approach employs domain adversarial …

The Influence Of Active Galactic Nuclei (Agn) Feedback On Star Formation In Spiral Galaxies, Moreom Akter

Theses and Dissertations

We investigate the influence of Active Galactic Nuclei (AGN) feedback on star formation in spiral galaxies by analyzing a sample of 324 red and 273 blue spiral galaxies from 115 low-redshift galaxy clusters. The multi-wavelength dataset combines optical emission line data from the Sloan Digital Sky Survey (SDSS), X-ray luminosity from the Chandra X-ray & XMM-Newton observatories, and ultraviolet (UV) and infrared (IR) measurements from GALEX and WISE. Using diagnostic emission line ratios, we constructed Baldwin, Phillips, and Terlevich (BPT) diagrams to classify galaxies based on nuclear activity. Our analysis reveals that most of the red spirals have AGNs and …

Advanced Motor Control Using Td3 Model-Free Reinforcement Learning, Muhammad Azam

Theses and Dissertations

Motor control plays a critical role in industrial automation, ensuring the precise regulation of speed, torque, and position across various applications. Traditional motor control techniques, such as open-loop, closed-loop, and feedback control, have been widely used but face limitations in handling complex and dynamic systems. Recent advancements in machine learning (ML) offer potential improvements in motor control by enabling systems to learn optimal control policies autonomously. This research investigates the integration of Reinforcement Learning (RL) with Field-Oriented Control (FOC) for the control of Permanent Magnet Synchronous Motors (PMSMs). The study aims to address a significant gap in reward function design, …

Evaluation Of Schlafen Family Proteins In Triple Negative Breast Cancer, Savannah Brown

Theses and Dissertations

This dissertation explores the role of Schlafen (SLFN) family proteins in Triple-Negative Breast Cancer (TNBC), a subtype known for its aggressive behavior and poor response to treatment. Through a series of studies, this dissertation examines the interplay between multiple SLFN proteins, chemotherapy resistance, and immune modulation, revealing the potential of SLFN12 as both a biomarker and therapeutic target for improving treatment outcomes, particularly in overcoming chemoresistance in TNBC.

Breast cancer, the most common cancer worldwide, includes various subtypes like TNBC, which lacks estrogen, progesterone, and HER2 receptors, making it resistant to conventional therapies. SLFN proteins, first discovered in mice, regulate …

Nanoscale Frictional Properties Of Two-Dimensional Snse And Snse2 With Lateral Force Microscopy, Thomas Iken

Theses and Dissertations

In this study, we employed an atomic force microscopy-based lateral force microscopy technique to examine the nanoscale frictional characteristics of 2D SnSe and SnSe2 layers, and we compared these results with those of graphene, a commonly used solid lubricant. Our results revealed that both SnSe and SnSe2 layers exhibited superior lubricative performance compared to graphene with similar thicknesses. Experimental results were further substantiated by extensive Density Functional Theory calculations to understand the observed frictional properties of these materials.

The Wicked Problem Of Moral Distress: Exploring The Experiences Of Rural Clinic Nurses, Sydney Rae Johnson

Theses and Dissertations

Background: Moral distress is an occupational hazard for nurses that can negatively impact nurses, patients, and the healthcare system. Moral distress has been well documented in high-risk care environments. Each nursing care environment has its own unique triggers for moral distress, but these triggers are unknown in rural clinic nurses. Design and Purpose: This convergent mixed methods study sought to gain a broader understanding of moral distress in nurses working in rural clinic settings.

Methods: Convergent mixed methodology was used to gain a broader understanding of moral distress in nurses working in rural clinic settings. Following ethical approvals, informed by …