Digital Commons Network^™

Hematologic And Solid-Organ Malignancy Risk In Antineutrophil Cytoplasmic Antibody (Anca)-Associated Vasculitis, Arjun Mahajan, Dorsa Moslehi, David W Bates

Faculty, Staff and Students Publications

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease characterized by small- and medium-vessel inflammation. Although chronic immune dysregulation and cytotoxic therapy exposure have been hypothesized to increase malignancy risk, large-scale, real-world evidence quantifying these risks has been limited. This study aimed to characterize hematologic and solid-organ malignancy risk profiles in patients with AAV using a large, multi-institutional database.

Methods: We conducted a retrospective cohort study using the TriNetX Research Network, using de-identified electronic medical record data from 2014 to 2024. We identified 19,238 patients with AAV and performed 1:1 propensity score matching to seborrheic keratosis controls …

Personalized Perioperative Opioid Strategies In Children: Focus On Methadone, Pharmacogenomics And Prevention Of Persistent Postoperative Opioid Use, Hamsa Priya Bhuchakra, Sennaraj Balasubramanian, Alivia G Nair, Isabella Marcos, Victoria Chen Falconett, Dominic Falcon, Ayesha Abdul Bari, Senthilkumar Sadhasivam

2020-Current year OA Pubs

Persistent postoperative opioid use (PPOU) is an emerging challenge in pediatric perioperative care, with rates as high as 4.7% in opioid-naive adolescents. Despite advances in multimodal analgesia, current protocols often fail to prevent long-term opioid exposure, particularly after high-risk surgeries such as spinal fusions. While multiple strategies exist to reduce PPOU in children, including regional anesthesia and non-opioid analgesics, this review specifically focuses on methadone and pharmacogenomic-guided opioid prescribing as promising approaches. Methadone, a long-acting opioid with mu-opioid agonism, NMDA antagonism, and monoamine reuptake inhibition, has shown encouraging outcomes in adult and emerging pediatric studies but remains underutilized due to …

Insm1 Governs A Neuronal Progenitor State That Drives Glioblastoma In A Human Stem Cell Model, Patrick A Desouza, Matthew Ishahak, Xuan Qu, Colin Mccornack, Devi Annamalai, Diane D Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T Vessoni, Ryan T Cleary, Rowland H Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, Ting Wang, Luis F Z Batista, Jeffrey R Millman, Albert H Kim

2020-Current year OA Pubs

Glioblastoma is a lethal brain cancer marked by functional plasticity driven by tumor cell-intrinsic mutations and their interplay with developmental programs. To investigate how canonical glioblastoma mutations promote functional plasticity, we have developed an isogenic human neural stem cell (NSC) model of glioblastoma by sequential addition of TERT promoter, TP53, and PDGFRA point mutations. TP53 loss-of-function increases TERT expression during serial mutagenesis, but only triple mutant NSCs reliably form lethal brain tumors in vivo that recapitulate glioblastoma. Tumor cell evolution triggers stress-related metabolic changes and transitions toward a neuronal progenitor network driven by transcription factor INSM1. INSM1 is highly expressed …

The Safety Kuznets Curve: Context In Occupational Safety, Andy Knickerbocker

ASEM Capstones

2025 ASEM 620 Capstone Project

Integrating A “World -Class” Safety System Into Diverse Teams, Mark D. Keller

ASEM Capstones

2025 ASEM 620 Capstone Project

Foundation Gift Benefits Children's Health Care, Bill Dabney

University of Mississippi News

OXFORD, Miss. – Some patients at Children's of Mississippi being treated for a craniofacial syndrome, cleft lip and palate or another craniofacial abnormality stand to benefit from a recent gift to the University of Mississippi Medical Center.

Rebuilding Trust In The Used Car Industry: A Five Forces Analysis, Ghaika Vera

Honors Capstones

Consumer distrust has become one of the greatest barriers to success in today’s automotive retail environment, especially within the used-car market where skepticism toward dealerships and repair services is widespread. This research investigates how dealerships can rebuild consumer confidence while also improving profitability and long-term competitive positioning. Using Porter’s Five Forces framework, the study analyzes key industry pressures including high buyer power, strong competitive rivalry, and increasing substitute transportation. Findings show that transparency, trust-building communication, and consistent relationship-based service are essential for sustainable differentiation. Strategies such as mobile-friendly scheduling systems, real-time repair updates, transparent pricing and inspection visuals, partnerships with …

Closeness, Conflict, And Achievement: The Role Of Parent–Child Relationships In Homeschooled And Public-Schooled Children, Celeste Gonçalves Tomaz

Honors Capstones

The parent–child relationship has been found to be a predictor of children’s academic and socio-emotional outcomes, with parent-child closeness linked to motivation and persistence (Mo & Singh, 2008; Silinskas & Kikas, 2022) and parent-child conflict associated with emotional and behavioral difficulties (Dotterer et al., 2008; Pinquart, 2017). The homeschooling context may increase these associations since children spend more time with their parents, who have caregiving and instructional roles (Padilla, 2021; Thomas, 2016). Even with growing research on academic and socio-emotional outcomes, few studies have examined whether the strength of the parent–child relationship is influenced negatively or positively by schooling type. …

State Of Technology Usage In Smaller Public Accounting Firms In 2025, Arun Kumararaj, Candice Hux

Honors Capstones

Prior research gives significant attention to technology usage of large public accounting firms, particularly the Big 4. However, limited evidence exists on the smaller public accounting firms, which constitute a majority of the public accounting field. In this study, we conducted semi-structured interviews with eight highly experienced professionals of smaller accounting firms. Findings reveal that firm size does not necessarily predict technological sophistication. Rather, individual leadership, including a single partner, emerges as a critical driver towards technological advancement. AI was primarily used for administrative tasks and, as of yet, the return on investment has been unclear. Despite this, all interviewees …

Technology, Education, Access, Communities And Healthcare: Teach Toward A Healthy Rural Wisconsin, Kathleen Abrahamson, Debbie Walrath, Shanon Brickner, Christine Davidson, Heidi Hansen, Seon Yoon Chung

Biennial Convention (CONV)

Purpose statement: The purpose of this project is to educate the future nursing workforce on tele-healthcare delivery skills that will reduce barriers to care and improve rural chronic illness outcomes in Wisconsin.

Background: Nearly one-third of Wisconsin citizens reside in rural areas (Wisconsin Policy Forum, 2023). Rural Wisconsinites are disproportionately at risk for adverse health outcomes (Rural Health Information Hub, 2023). A lack of available healthcare services and providers in rural Wisconsin compounds this risk. All non-metropolitan counties in Wisconsin experience a shortage of primary care providers (U.S. Department of Health & Human Services, 2023). Nurse-supported telehealth services provide a …

Adaptive Image Acquisition Algorithms For Resource-Constrained Single-Photon Cameras, Yeganeh Jalalpour, Wu-Chi Feng

Computer Science Faculty Publications and Presentations

Emerging single-photon camera (SPC) technologies have unique challenges in data acquisition and processing. Unlike conventional sensors that produce a single 8- to 16-bit brightness value per pixel, SPCs record photon arrivals with many more samples per pixel, using high floating-point precision for each photon collected. This means that they must handle potentially millions of timestamps, especially at higher spatial resolutions and in the presence of ambient light, creating bottlenecks within the pixel circuitry. To address these challenges associated with SPCs, this paper proposes adaptive algorithms designed to efficiently distribute hardware resources among groups of pixels. By selectively subsampling the data …

The Reception Of Neurodiversity Represented Within Netflix’S Wednesday, Anna Stevens

Graduate Theses & Dissertations

This paper explores how neurodiversity is represented through popular media - particularly Netflix's show Wednesday - and aims to discuss the effects this representation could have in regards to how it's received by the public, as well as those who are neurodiverse.

Proteome-Wide Association Study Of Prostate Cancer Risk Across Populations, Hua Zhong, Jingjing Zhu, Shuai Liu, Chong Wu, Liang Wang, Seamus P. Whelton, Catherine H. Marshall, Michael J. Blaha, Peter Durda, Xiuqing Guo, Craig W. Johnson, Henry J. Lin, Kent D. Taylor, Russell P. Tracy, Ronit I. Yarden, Ani W. Manichaikul, Stephen S. Rich, Jerome I. Rotter, Rajat Deo, Ruth F. Dubin, Peter Ganz, Lang Wu

School of Graduate Studies Faculty Publications

There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450), European (n = 758), Asian (n = 289), and Hispanic/Latino (n = 474) males, respectively, and evaluate associations of genetically regulated protein expression with PCa risk in 19,391 PCa cases and 61,608 controls of African population, 122,188 cases and 604,640 controls …

An Updated Annotated Checklist Of The Mammals Of The Crane Trust, Hall County, Nebraska, Bethany L. Ostrom, Amanda H. Medaries, Andrew J. Caven, Jenna M. Malzahn, Alexa Rojas, Matthew R. Schaaf, David M. Baasch, Thomas E. Labedz, Greg D. Wright

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The Crane Trust is a regional nonprofit conservation organization that has protected land in the biologically important Central Platte River Valley for over four decades. A mammal inventory was conducted on the Crane Trust’s main habitat complex in 1980. Since, a variety of environmental conditions have shifted locally, regionally, and globally. An analysis of the mammal community was conducted using past and recent data to determine how species composition and relative abundance have shifted categorically from 1980 to 2021. We used all available data to categorize relative abundance during two distinct time periods per a modified “DAFOR” scale including 7 …

Effect Of Low Intensity Aerobic Exercise On Vo2peak Of Women With Breast Cancer Undergoing Chemotherapy, Etta Novayanti, Indrayuni Lukitra Wardhani, Inggar Narasinta, Desak Gede Agung Suprabawati, Niken Pratiwi, Ratna Daryanti Soebadi

Folia Medica Indonesiana

Breast cancer treatments, particularly chemotherapy, have been associated with significant declines in cardiopulmonary fitness, a key determinant of functional independence and survival. VO₂peak, a marker of cardiopulmonary function, is often reduced in patients undergoing chemotherapy, increasing morbidity risks. Researchers have proposed exercise interventions to mitigate these effects. However, most studies focused on moderate-to-high-intensity regimens, with limited data on the efficacy of low-intensity aerobic exercise. This study aimed to explore the impact of low-intensity cycle ergometer aerobic exercise on VO₂peak in women undergoing chemotherapy for breast cancer. A randomized controlled trial with twenty participants randomly assigned to …

Factors Associated With Medication Adherence And Systolic And Diastolic Blood Pressure Of Hypertensive Patients, Hamka Ziddan, Meity Ardiana, Linda Dewanti, Anudya Kartika Ratri

Folia Medica Indonesiana

Uncontrolled hypertension can cause complications such as heart disease, brain disease, kidney disease, and other diseases. Medication adherence is a primary factor in controlling blood pressure (BP) in hypertensive patients. This study aims to provide an overview of the factors associated with medication adherence of hypertensive patients treated at Taman Public Health Center in Sidoarjo, Indonesia. This study used a cross-sectional approach involving hypertensive patients. This study employed consecutive sampling, with the number of samples comprised of patients undergoing outpatient care from January 2, 2023, to February 25, 2023, totaling 103 respondents. The study employed the Morisky Medication Adherence Scale …

Innovative Offshore Transition-To-Practice Model For International Nurses Using Tele-Simulation, Lisa Mceathron, Christian Striggow, Jose Arnold Tariga

Biennial Convention (CONV)

Empirical evidence underscores the importance of optimal nurse staffing in delivering high-quality patient care, improving outcomes, and enhancing nurse well-being. Internationally educated nurses (IENs) play a crucial role in addressing staffing shortages in the United States, yet they face challenges in bridging gaps between varying international nursing standards and US healthcare practices. Innovative approaches are essential to ensure their readiness to integrate effectively prior to arrival.

The International Transition to Practice Program leverages tele-simulation as a pioneering strategy to address these challenges, providing an offshore, immersive learning experience for IENs. This program was implemented from July 2023 to September 2024, …

Elm: The Case Of Experiential Programming, Matthew Miller, Lynette Campogiani

Faculty and Staff Publications & Presentations

Experiential Programs (EPs) provide immersive, destination-focused experiences within luxury resort settings. However, research has yet to apply the elaboration likelihood model (ELM) to examine how guests evaluate their experiences with EPs, particularly within luxury tourism or resort contexts. Using the ELM framework, this study examined how the experience of luxury resort EPs influences guests’ revisit intentions. Guests’ experiences were categorized into central and peripheral processing cues and qualitative interview responses were analyzed. The findings indicate that elements such as ambient music and scenic views associated with peripheral processing had a significantly stronger positive impact on guests’ intentions to return than …

The Formation And Dynamics Of Colonial “Lived Spaces” : Urban Space And Society In Colonial Hanoi, 1883–1916, Nam Khanh Hoang '25

Student Research

This study examines the nuanced experiences and perceptions of urban space among different social groups in colonial Hanoi in the late nineteenth and early twentieth centuries by analyzing the French colonial agendas, as reflected through modern urban planning and practices, and its reception among the colonial urban inhabitants, as suggested through their responses to the Statue of Liberty—a colonial urban monument. While existing scholarship has often framed colonial cities as stages for consolidating imperial power, introducing Western ideals of modernity, and forming systems of oppression and exploitation against colonial subjects, it has often overlooked the perceptions and experiences of colonial …

Proteome-Wide Association Study Of Prostate Cancer Risk Across Populations, Hua Zhong, Jingjing Zhu, Shuai Liu, Chong Wu, Liang Wang, Seamus P Whelton, Catherine H Marshall, Michael J Blaha, Peter Durda, Xiuqing Guo, Craig W Johnson, Henry J Lin, Kent D Taylor, Russell P Tracy, Ronit I Yarden, Ani W Manichaikul, Stephen S Rich, Jerome I Rotter, Rajat Deo, Ruth F Dubin, Peter Ganz, Lang Wu

Faculty, Staff and Student Publications

There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450), European (n = 758), Asian (n = 289), and Hispanic/Latino (n = 474) males, respectively, and evaluate associations of genetically regulated protein expression with PCa risk in 19,391 PCa cases and 61,608 controls of African population, 122,188 cases and 604,640 controls …

Actin Dysregulation Induces Neuroendocrine Plasticity And Immune Evasion: A Vulnerability Of Small Cell Lung Cancer, Yoojeong Seo, Shengzhe Zhang, Jinho Jang, Kyung-Pil Ko, Kee-Beom Kim, Yuanjian Huang, Dong-Wook Kim, Bongjun Kim, Gengyi Zou, Jie Zhang, Sohee Jun, Wonhong Chu, Nicole A Kirk, Ye Eun Hwang, Young Ho Ban, Shilpa S Dhar, Joseph M Chan, Min Gyu Lee, Charles M Rudin, Kwon-Sik Park, Jae-Il Park

Faculty, Staff and Student Publications

Small cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. Capping protein inhibiting regulator of actin dynamics (CRACD) that promotes actin polymerization, is frequently inactivated in SCLC. However, the role of CRACD loss in SCLC is unknown. Here we show that CRACD depletion drives neuroendocrine (NE) cell plasticity and immune evasion in SCLC. Mechanistically, CRACD inactivation disrupts actin organization, leading to suppression of Yap1-NOTCH signaling and subsequent NE gene upregulation. Simultaneously, CRACD loss drives EZH2-mediated histone methylation via nuclear actin disruption, leading to repression of MHC-I genes and depletion of CD8⁺ T cells. Consequently, CRACD-downregulated tumors exhibit …

Islamic Prophetic Counseling: An Intervention Strategy In Developing Students' Noble Character, Hardi Santosa, Ahmad Zaki Annafiri, Iin Inawati, Akhmad Fajar Prasetya, Muhammad Sabri Bin Sahrir

Buletin Konseling Inovatif

This study aims to test the effectiveness of Islamic prophetic counseling in developing students' noble morals. The research method uses a true experiment involving a control group. The selection of the control group uses the waiting-list control group model, with consideration of the ethical aspects of the study. The research sample involved 244 students captured the profile of noble morals and their spiritual activism. While the hypothesis test involved 50 students who were divided into control and experimental groups. The sample selection was carried out randomly with the random assignment technique. The research data were collected using a noble moral …

Opportunities, Challenges, And Realities Of Graduate Student Submissions In Institutional Repositories: One Librarian’S Reflection, Sierra Pandy

Journal of Graduate Librarianship

The role of an institutional repository (IR) is to provide open access publishing and archival services for the institution’s faculty, staff, and students. However, despite the wide range of benefits this creates for university researchers, it can be difficult to communicate that value to graduate students. This article will discuss and reflect upon the various challenges, successes, and opportunities we experienced while promoting and utilizing the IR for graduate students at the University of Wyoming during and after a major platform migration, and touch upon goals for the future.

Bringing Mutuality And Reciprocity Into Focus: A Case Study On Sustaining University-Community Partnerships For Local Systems Change And Student Learning, Jessica L. Lucero, Lucas Martin, Jayme Walters

Transforming Communities

This case study explores a long-term university-community partnership focused on addressing homelessness, highlighting the principles of mutuality and reciprocity in achieving systemic change. Over nearly a decade, the partnership has evolved to engage university resources, faculty, and social work students through research, courses, and outreach activities, such as community surveys, the Point-in-Time Count, strategic planning, advocacy, and service system expansion. These collaborative efforts have contributed to enhanced public awareness, increased state funding, and the establishment of vital services, including a warming center. The case study also underscores the challenges inherent in community-engaged scholarship, including capacity constraints like funding and staffing …

Evaluating Mid-Air Fog-Screen Robot System, Hong Wang, Ngoc Bao Dinh, Waylon Erlandson, Jacob Rauscher, Mario Sinclair, Nicolas Echeverria, Abrar Zahin, Zhao Han

Bellini College REU Symposium (BCREUS)

This project investigates how communication interfaces can bridge the gap between humans and robots in hazardous reconnaissance environments. The study explores a communication framework designed to overcome the limitations of headset-based solutions such as poor scalability, and projector-based spatial AR that rely on vertical surfaces often absent in open or unstructured environments. Through the development of a signaling system, the project aims to provide clear transmission of mission-critical safety information without reliance on headsets, network connectivity, or close-proximity displays. Previous results suggest that this approach improves information clarity for the operator compared to standard screen-based methods. The project advances this …

A Universal Evaluation Framework For Visual Noise In Contained Systems, Temirzhan Mukhambet, Duong Mai, Jacqueline Hausman, Yu Sun

Bellini College REU Symposium (BCREUS)

In many robotics or computer vision contained systems, regulating the quality of captured input data (e.g., point clouds or videos) is critical for preserving the integrity and accuracy of downstream tasks. In practice, this process requires mitigating various forms of noise specific to the domain (2D vs. 3D) and the intended application, such as object detection and scene understanding.

However, a unified framework addressing noise across a holistic system remains underexplored, as current surveys typically isolate specific modalities i.e., examine either 2D or 3D methods exclusively. The 2D domain covers two main areas: static image denoising, which prioritizes sensor noise …

Analyzing Human–Robot Collaboration Failures In State-Of-Art Generative Visuomotor Models, Grant Henderson, Miguel Mateo Osorio Vela, Vidhi Mudaliar, Amanuel Ergogo, Zhao Han

Bellini College REU Symposium (BCREUS)

As generative visuomotor models become increasingly capable of representing large-scale robotic skills, they are beginning to transition from controlled laboratory environments into shared human-robot workspaces. While these models enable competent manipulation, their opaque, black-box decision-making processes introduce coordination challenges that can negatively impact safety, efficiency, and trust during collaboration. In safety-critical tasks such as medication dispensing, successful teamwork depends not only on physical capability but also on timing, predictability, and mutual awareness.

This project investigates how two state-of-the-art generative visuomotor policies, an Action-Chunking Transformer (ACT) and a Vision-Action Diffusion policy, perform in a real-world collaborative medication-dispensing task. We compare these …

On-Device Measurement Of Impact Of Artificial Intelligence Tools On Productivity, Navid Kagalwalla, Tom Piacentini, Jacques Mouton

Defensive Publications Series

This disclosure describes techniques to measure the net productivity impact of AI-assisted workflows on user productivity. Metadata regarding user activity on a user device is obtained with user permission, using a private, on-device architecture. The data is analyzed on-device to determine whether an AI-assisted workflow is in process and the impact of the use of AI on productivity. In an example implementation, an Activity Sensing and Filtration Layer (ASFL) and a Cognitive Workflow Engine (CWE) are implemented and used to calculate the true net time saved using AI assistance. This metric takes into account the hidden cost of the user …

A Distance Based Embedding Method Using Nlp Methods To Identify Proximity To A Network, Shuhan Zhang, Anurag Tangri, Chinmay Narendra Sonar, Lin Meng, Can Liu, Chiranjeet Chetia

Defensive Publications Series

The present disclosure relates to the field of Artificial Intelligence (AI), in particular to AI methods and systems for analyzing transactional data using Natural Language Processing (NLP) techniques to identify latent relationships and proximity within networks. The disclosed system utilizes text fields within datasets to categorize input data into appropriate classifications. The input comprises a dataset containing text data that provides contextual information related to transactions. Feature embeddings are generated using a sentence-based Language Learning Model (LLM), which captures semantic meaning of sentences. The LLM converts input data of varying lengths into fixed-dimension embeddings. The sentence-based LLM is fine-tuned based …

Llm-Augmented Dynamic Selective Blocking Of Service Calls For Application Control, Johannes Start, John Lunney

Defensive Publications Series

Software applications face critical challenges in rapidly and precisely mitigating emergent threats such as safety incidents or query-of-death attacks originating from or affecting backend calls. This disclosure describes techniques for dynamic, real-time, intelligent blocking or modification of harmful or problematic backend service call responses. The techniques combine traditional filtering with semantic analysis using a large language model (LLM). A control plane enables operators such as site reliability engineers (SREs) to define and deploy mitigation rules on-the-fly, without code changes or lengthy propagation delays. This enables rapid and precise response to emergent threats, such as safety incidents involving AI-generated content or …