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Full Issue - The Crown, Vol. 2, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

Therapeutic Mechanisms Of A Lilium Brownii -Plantago Asiatica L.Compound Solid Beverage Against Hyperuricemia, Feng Li, Jiawei Huang, Xiaowen Guo, Lulu Jiang, Hongyan Zhao, Qiang Li, Chenxiang Sun, Shuying Feng, Qianqian Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the ameliorative effects of a Lilium brownii -Plantago asiatica L.compound solid beverage on hyperuricemia and to elucidate its potential mechanisms.[Method ] Network pharmacology was employed to screen the active constituents,potential targets,and related pathways.Key targets were identified based on a protein-protein interaction (PPI) network.Molecular docking was conducted between the key proteins and active constituents.An animal experiment was performed to validate the effects of the compound solid beverage on serum uric acid levels,renal function indices,activities of uric acid-producing enzymes,and the levels of renal urate transporters.[Result ] Network pharmacology analysis indicated that Lilium brownii and Plantago …

Faculty Senate Executive Committee Agenda December 15, 2025, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes November 17, 2025
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:35 Information
• EPC Report - December 4, 2025
• 3:40 Report
• Council on Teacher Education
• Scholarship Annual Report
• University Studies Report
• 4:05 Old Business
• 4:10 New Business
• Adjourn: 4:30 pm

Visual Detection Of Seizures In Mice Using Supervised Machine Learning., Gautam S Sabnis, Leinani Hession, J Matthew Mahoney, Arie Mobley, Marina Santos, Brian Q Geuther, Vivek Kumar

Faculty Research 2025

Seizures are caused by abnormal synchronous brain activity. The resulting changes in muscle tone, such as twitching, stiffness, or jerking, are used in visual scoring systems such as the Racine scale to quantify seizure intensity. However, visual inspection is time consuming, low throughput, and partially subjective, and there is a need for scalable and rigorous quantitative approaches. We used supervised machine learning approaches to develop automated classifiers to predict seizure severity directly from non-invasive video data. Using the pentylenetetrazole (PTZ)-induced seizure model in mice, we trained video-only classifiers to predict ictal events and combined these events to predict composite seizure …

Tea As An Herbal Medicine, Pannawat Chaiyawatthanananthn

Asian Medical Journal and Alternative Medicine

No abstract provided.

First_Page Settings Order Article Reprints Open Accessarticle Quantitative Detection Of Salmonella Typhimurium In Ground Chicken Using A Surface Plasmon Resonance (Spr) Biosensor, Sandhya Thapa, Fur-Chi Chen

Food and Animal Sciences Faculty Research

Regulatory agencies worldwide have implemented stringent measures to monitor and reduce Salmonella contamination in poultry products. Rapid quantitative detection methods enable producers to identify contamination early, implement corrective actions, and enhance food safety. This study aimed to develop and optimize a surface plasmon resonance (SPR) biosensor for the quantitative detection of Salmonella Typhimurium in ground chicken. The sensor surface was functionalized with a well-characterized monoclonal antibody specific to Salmonella flagellin, and an SPR workflow was established for quantitative analysis. Ground chicken samples were inoculated with four S. Typhimurium strains at contamination levels ranging from −0.5 to 3.5 Log CFU/g and …

Application Of A Rapid Test Strip Method In Quantitative Detection Of Microorganisms In Chilled Meat, Yanzhen Zhang, Ning Liu, Wei Wang, Xianqi Yao, Laixue Ni, Yunguo Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to evaluate the feasibility of using the rapid test strip method for detecting key microbial quality control indicators in chilled meat,specifically the total plate count and Escherichia coli /coliforms.[Method ] The performance of the rapid test strip method was assessed through repeatability tests,and the national standard plate count method was used as the reference for method comparison.Statistical significance of the quantification results was analyzed by a t-test,and linear regression was adopted to analyze the correlation.[Result ] The repeatability deviation of the rapid test strip method (r≤0.25) met the requirements of ISO 4833—1:2013.No significant difference was …

Design , Expression , And Stability Evaluation Of A Superoxide Dismutase-Catalase Fusion Protein, Zhuo Jiang, Weina Lu, Qi Lin, Zhan Luo, Zhengbin Lyu, Zuoming Nie

Journal of Food Science and Biotechnology

[Objective ] This study aims to design a fusion protein with high activities and high stability of superoxide dismutase (SOD ) and catalase (CAT ).[Method ] Using AcSOD 11 and FeCAT proteins as the research subjects,three fusion proteins of SOD and CAT were designed:AcSOD 11-(GGGGS )*3-FeCAT,FeCAT-(GGGGS )*3-AcSOD 11,and FeCAT- (EAAAK )*3-AcSOD 11,which were named AcSOD 11-G3-FeCAT,FeCAT-G3-AcSOD 11,and FeCAT-E 3-AcSOD 11,respectively.Soluble expression of these three fusion proteins was achieved in Escherichia coli BL21(DE3).The thermal stability and pH stability of the three fusion proteins were then assessed.[Result ] The three fusion proteins showed no significant difference in the specific activity of SOD,while …

Sticker Or No Sticker, That Is The Question: A Test Of Two Competing Hypotheses, Dongdong Yang, Yi Luo, Marylou Naumoff

College of Communication and Media Scholarship and Creative Works

Stickers, as an important nonverbal communication affordance on social media, have been understudied in Western contexts. This study employed an online survey (N = 300) to test two competing hypotheses—the social compensation and withdrawal hypotheses—to examine how personality traits influenced sticker use for emotional expression and self-presentation among U.S. college students. Results demonstrated that when communicating with a new friend on their mobile messenger, participants used stickers more frequently for self-presentation than emotional expression. Moreover, loneliness was positively related to neuroticism and negatively related to agreeableness and extraversion. Neuroticism was negatively related to sticker use for both emotional expression and …

Professor Yvette Butler Named 2026 Recipient Of Derrick A. Bell, Jr. Award, Maurer School Of Law - Indiana University

Keep Up With the Latest News from the Law School (blog)

Indiana University Maurer School of Law Professor Yvette Butler has been selected as the 2026 recipient of the Derrick A. Bell, Jr. Award, the Association of American Law Schools (AALS) Section on Minority Groups announced late Friday (Dec. 12).

“Professor Butler’s commitment to advancing racial justice and elevating the voices of marginalized communities embodies the highest ideals of our profession,” said Indiana Law Dean Christiana Ochoa. “Her work reflects the courage, clarity of purpose, and unwavering advocacy that defined Derrick Bell’s legacy. We are immensely proud to see her recognized with this award and look forward to the continued impact …

Loss Of Mfap5 And Its Effect On Skin Homeostasis And Wound Healing, Chen Han, Heidi Yuan, Timothy J Koh, Lin Chen, Robert P Mecham, Luisa A Dipietro

2020-Current year OA Pubs

MFAP5, also known as microfibrillar-associated glycoprotein-2 (MAGP2), may influence parameters of skin wound healing related to scar formation. To further elucidate its role in skin wound healing, we assessed skin wound repair in Mfap5

2d-Nanosilicate Carriers For Sustained Delivery Of Vaccine Components, Chih Yun Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Laponite® 2D Nanosilicates (NS) are disc-shaped platelets (~30 nm diameter, ~1 nm thick) with positively charged edges and negatively charged faces, capable of loading proteins, drugs, and nucleic acids via electrostatic interactions to form a house-of-cards gel that sequesters cargo. Here, we evaluated NS for sustained delivery of antigens and Toll-like receptor (TLR) agonists to extend germinal center duration and enhance antibody quality. The model antigen ovalbumin (OVA) was adsorbed onto NS at acidic pH in a ~1:1 ratio, with partial unfolding that remained stable at physiological pH. NS-OVA complexes were efficiently internalized by dendritic cells, with uptake driven primarily …

Listening To Life In A Noisy World: The Pitfalls And Promise Of Urban Acoustic Ecology, Leah O'Barr

Undergraduate Honors Theses

This thesis examines the application of soundscape ecology principles to urban settings. Soundscape ecology is the study of the entire sonic makeup of a community, composed of biophony (biological sound), geophony (environmental sound), and anthrophony (human-generated sound). By examining the changes in and qualities of the soundscape, researchers can gain information about the biological makeup and ecological quality of an area, and the temporal and spatial distribution of resident species. Recent technological advances in recording equipment and machine learning methods are making soundscape ecology an increasingly relevant and practical tool.

Applying soundscape ecology methods to urban ecosystems introduces unique challenges, …

From Drawing To Architecture: Michelangelo’S (Anti)Architectural Methodology, Yida Li

The Crown: Syracuse Honors Research Journal

This paper investigates Michelangelo Buonarroti’s unique approach to architecture through the lens of his drawing practice, arguing that his architectural methodology evolved as an extension—and at times a deliberate rejection—of Renaissance architectural conventions. Beginning from his assertion that “architecture is not my profession,” the study situates Michelangelo’s creative identity within his grounding in disegno, the Renaissance concept that framed drawing as an intellectual act of conception rather than mere representation. Through comparative analysis with Leonardo da Vinci, the research traces how Michelangelo adapted the iterative, investigative qualities of draw-ing into a sculptural and spatial process that defied the rational, arithmetic-based …

Facts And Hopes Of Chimeric Antigen Receptor-Redirected Nk T Cells, Amy N Courtney, Xin Zhou, Gengwen Tian, Ying Wang, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-engineered invariant NK T cells (CAR-NKT) are a novel cell platform for cancer immunotherapy. Unlike conventional T cells, NKTs are characterized by innate antitumor properties, minimal alloreactivity, and a unique ability to modulate the tumor microenvironment. This article provides a comprehensive overview of preclinical and early clinical studies evaluating CAR-NKTs in both autologous and allogeneic clinical settings. We discuss the contributions of CAR signaling domains, cytokine coexpression, and other functional measures that correlate with CAR-NKT persistence, function, and metabolic fitness. We also discuss the critical role of immunocompetent animal models in elucidating the interactions of CAR-NKTs with …

Mitochondrial Complex Ii Orchestrates Divergent Effects In Cd4+ And Cd8+ T Cells, Keisuke Seike, Shih-Chun A Chu, Yuichi Sumii, Takashi Ikeda, Meng-Chih Wu, Laure Maneix, Dongchang Zhao, Yaping Sun, Marcin Cieslik, Pavan Reddy

Faculty, Staff and Students Publications

Mitochondrial metabolism orchestrates T cell functions, yet the role of specific mitochondrial components in distinct T cell subsets remains poorly understood. Here, we explored the role of mitochondrial complex II (MC II), the only complex from the electron transport chain (ETC) that plays a role in both ETC and metabolism, in regulating T cell functions. Surprisingly, MC II exerts divergent effects on CD4+ and CD8+ T cell activation and function. Using T cell-specific MC II subunit, succinate dehydrogenase A-deficient (SDHA-deficient) mice, we integrated single-cell RNA-seq and metabolic profiling, with in vitro and in vivo T cell functional assays to illuminate …

A Long Non-Coding Rna Leat1 Mediates The Hormone Responsiveness Of Efnb2 During Male Urogenital Development, Deidre Mattiske, Pascal Bernard, Paul E Gradie, Richard R Behringer, Paul A Overbeek, Rachel J O'Neill, Tiffany Phillips, Melanie Stewart, Neil Youngson, Gerard Tarulli, Andrew J Pask

Faculty, Staff and Students Publications

The novel long non-coding RNA (lncRNA) Leat1 is extraordinarily conserved in both its location (syntenic with EfnB2, an essential gene in anogenital patterning) and sequence. Here we show that Leat1 is upregulated following the production of testosterone from the developing testis in mice and interacts with EfnB2, positively regulating its expression. Leat1 expression is suppressed by estrogen, which in turn suppresses the expression of EfnB2. Moreover, the loss of Leat1 leads to reduced EfnB2, resulting in a severe hypospadias phenotype. The human LEAT1 gene is also co-expressed with EFNB2 in the developing human penis, suggesting a conserved function for this …

Commonthought (2025), Commonthought Staff

Commonthought

This issue features works created by Lesley University students and covers a broad range of topics. The work itself crosses many disciplines from creative writing to visual arts.

Beyond Additive Risk: Longitudinal Associations Between Discrimination And Positive Affect Development Among Adolescents With Single And Multiple Marginalized Identities, Vanni Jefferson V. Arcaina

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adolescents with marginalized identities often face chronic exposure to discrimination, a social stressor linked to a range of negative mental health outcomes. While much of the existing literature focuses on internalizing symptoms, fewer studies have explored how discrimination may disrupt the development of positive affect (POA), which is a core dimension of emotional well-being linked to resilience, identity formation, and long-term health. The present study examined how overall, race/ethnicity-based, and sexual minority (SM)-based discrimination affects longitudinal patterns of POA among adolescents with single or multiple marginalized identities. Drawing on four waves of data from the Adolescent Brain Cognitive Development Study, …

Acute And Chronic Effects Of Neuroinflammation On Hippocampus And Anterior Cingulate Cortex Network Dynamics, Lauren A. Crew

UNLV Theses, Dissertations, Professional Papers, and Capstones

Neuroinflammation has emerged as a critical modulator of cognitive function and neural circuit dynamics, yet the distinct contributions of acute and chronic neuroinflammation to brain function remain poorly defined. This dissertation examines how inflammation independently alters large-scale neural activity and behavior, focusing on interactions between the hippocampus (HPC) and anterior cingulate cortex (ACC), regions essential for memory and executive processes. Using in vivo electrophysiological techniques in a rodent model, this study compares the effects of short-term (acute) and prolonged (chronic) neuroinflammatory states, induced via Poly I:C, on neural oscillations, regional coherence, and spatial coding. Findings reveal that even transient inflammation …

Geometric And Proximity Based Substrate Targeting By Cullin-Ring Ligases, Jerry Li

UNLV Theses, Dissertations, Professional Papers, and Capstones

Homeostasis, the process of maintaining stable biochemical and biophysical conditions, is a fundamental facet of cellular viability. Biochemical homeostasis is critical to support the biological functions that sustain living organisms. Protein ubiquitylation is one of the primary cellular pathways that regulate protein homeostasis and turnover. Ubiquitylation is initiated through the conjugation of a small globular protein known as ubiquitin, onto a given substrate. There exists a myriad of cellular fates that ubiquitylated proteins may undergo, but the most widely studied pathway is protein degradation, whereby a ubiquitylated protein substrate is shunted to a large macromolecular protease known as the proteasome, …

Demographic Similarity, Psychopathy, And Perceived Inherent Value: An Investigation Of Factors Influencing Moral Decision Making, Ashley Michelle Poston

UNLV Theses, Dissertations, Professional Papers, and Capstones

The present study experimentally manipulated the demographic characteristics of the subjects of moral dilemmas such that they were 20%, 40%, 60%, and 80% demographically similar to participants. Participants rated each of these individuals on a novel measure of perceived inherent value, the Perceived Inherent Value Scale (PIVS) and responded to a series of moral dilemmas using the Consequences, Norms, and preference for Inaction (CNI) model of moral decision making where the subjects of the moral dilemmas were the 20%, 40%, 60%, and 80% similar individuals. Participants rated individuals who were more demographically similar to themselves as having greater perceived inherent …

Modeling The Mojave: A Multiphase, Mixed Methods Phenomenological Investigation Of Novice Understanding Of A Complex Ecological System, Nicole Juliana Thomas

UNLV Theses, Dissertations, Professional Papers, and Capstones

This research explores early college science majors’ conceptions of the Mojave Desert ecosystem as a complex system. A multi-level, explanatory sequential mixed methods design was employed to study college science majors’ understanding of the Mojave Desert ecosystem to better inform science pedagogy. The first level, the quantitative phase of the study, consisted of developing a mathematical representation of twelve ecosystem variables present within the Mojave Desert. The second level, the qualitative phase of the study, consisted of phenomenological semi-structured interviews with 23 early college science majors. The findings of this research suggest that the Mojave Desert operates as a complex, …

Migratory Songbirds As Potential Ectozoochorous Protist Dispersal Vectors, Silas E. Fischer, Joy J. Jackson, Elise C. Hoffman, Henry M. Streby, Trisha L. Spanbauer

Earth and Environmental Sciences Faculty Publications

Protist biogeography, speciation, and systematics continue to generate debate and inquiry because protist distributions and dispersal remain poorly resolved. Identifying potential vectors and basibionts for epibiont protists would contribute to our limited understanding of their ecology. Migratory animals seasonally link disparate landscapes, incidentally transporting other organisms in the process. Waterbirds are known microbe dispersers, but evidence for other avian groups is limited-such as taxa that often migrate longer distances. We asked whether terrestrial songbirds (Passeriformes) host diatoms (Bacillariophyta) by sampling tail plumage of four thrush species (Hermit Thrush Catharus guttatus, Swainson's Thrush C. ustulatus, Wood Thrush Hylocichla mustelina, American Robin …

Eyetracking Measures Of Performance On The Traveling Salesperson Problem, Kanan Levy

Undergraduate Honors Theses

Human solutions to the Traveling Salespersons Problem (TSP) have been proposed to employ heuristics integrating global and local spatial information (Pizlo et al., 2006). Because different neuroanatomical regions may be involved in local vs. global processing, as well as attentional shift between levels, performance on the TSP may provide useful insight into changes that occur in the brain as a result of age or of neurodegenerative disorders (Slavin, 2002). In a previous study, we compared the cognitive processes used to solve spatial problems on a large scale (moving through space) and on a small scale (on a sheet of paper). …

Fabrication Of Three-Dimensional Seaweed-Based Scaffolds And Evaluation Of Cell Attachment And Viability For Cultured Meat Applications, Srishti Tandon

Honors Scholar Theses

Global demand for animal protein is increasing rapidly, underscoring the need for sustainable meat production. Cultured meat is a promising alternative to traditional meat production techniques, but it requires optimization before it can be implemented on a large scale. Scaffolds are an important component for making cultured meat, as they provide structural support for cell attachment and mimic the texture of meat. Scaffolds need to be biocompatible, mechanically supportive, and biochemically active to promote proper cell adhesion, proliferation, and differentiation. This project investigated brown seaweed extract (SWE) hydrogels as a scaffold for cultivated meat applications and compared their mechanical and …

Plant Preservation: The Contribution Of Bacteriophage And Transposons To Pathogenic Xanthomonas Evolution, And The Demographic And Reproductive Analysis Of Castilleja Parvula, Ciara A. Green

Theses and Dissertations

Plant preservation, whether through disease research or endemic extinction analyses, plays an important role in the relationship between humans and our surrounding environment. In these analyses, both the role of mobile elements in the evolution of pathogenic Xanthomonas sp. bacteria, and the demographic and reproductive analysis of Castilleja parvula, an imperiled alpine plant, are evaluated. Xanthomonas species are one of the top agricultural threats, and are known to evolve rapidly. Until now, the contributions of mobile elements and particularly bacteriophage have not been thoroughly evaluated. The contribution of these agricultural diseases to food insecurity and the devastation of crops that …

Teaming With Insects: Entomology For Grades 3-12, Natalie J. Carroll, Christian Y. Oseto, Timothy J. Gibb

Purdue University Press Books

Teaming With Insects: Entomology for Grades 3–12 is written for youth who enjoy learning about and studying science and nature. Insects have been around for millions of years and have evolved and adapted to many different habitats. Adaptations involving their anatomy, physiology, and behavior are what make insects so diverse and interesting. More than 1 million species of insects are known to scientists, and they believe there may be up to 40 million more we have yet to discover. Most people consider insects pests, and some insects do damage to homes, plants, crops, and stored foods. Others harm humans and …

Stability Analysis Of Thermohaline Convection With A Time-Varying Shear Flow Using The Lyapunov Method, Kalin Kochnev

Honors Scholar Theses

This work applies the Lyapunov method to identify instabilities and compute the growth rate of a linear time-varying system. The linear system studied describes cold fresh water on top of hot salty water with a periodically time-varying background shear flow. A time-dependent weighting matrix is employed to construct a Lyapunov function candidate. The resulting linear matrix inequalities are discretized in time using the forward Euler method. As the number of temporal discretization points increases, the growth rate predicted by the Lyapunov method or Floquet theory, used for comparison, will converge to the same value obtained from numerical simulations. Furthermore, the …

Classification Of Cases Of Animal Abuse In Ecuador Using Indetermsoft And C4.5 Algorithms, Viviana Del Rocío Marfetan Marfetan, Lesly Gissela Tipanguano Chicaiza, Styven Andrés Pila Chicaiza, Estephany Monserrath Ojeda Sanchez

Neutrosophic Sets and Systems

This dissertation aimed to determine the classification of animal abuse within Ecuador by severity, context, and solution through the application of IndetermSoft and the statistical-neutrosophic C4.5 algorithm to classify the uncertainty associated with judicial and administrative efforts for animal protection for domestic dogs and cats. The approach was qualitative and documentary, analyzing judicial sentences, citizen complaints, and municipal ordinances within the three largest Ecuadorian cities of Quito, Guayaquil, and Cuenca to acquire the determination of classifications of animal abuse, subsequent sanctions, and follow-ups. A modeling of IndetermSoft ensembles assessed the indeterminacy of subsequent actions, and inputted into IndetermSoft and the …