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2025

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Sex-Specific Associations Between Early Life Unpredictability And Trajectories Of Body Mass Index From Infancy To Adolescence, Emily M. Melnick, Lilybelle K. Deer, Jenalee R. Doom, Hal S. Stern, Curt A. Sandman, Laura M. Glynn, Elysia P. Davis Sep 2025

Sex-Specific Associations Between Early Life Unpredictability And Trajectories Of Body Mass Index From Infancy To Adolescence, Emily M. Melnick, Lilybelle K. Deer, Jenalee R. Doom, Hal S. Stern, Curt A. Sandman, Laura M. Glynn, Elysia P. Davis

Psychology Faculty Articles and Research

Objective:

Unpredictability in early life is an understudied aspect of early life adversity that provides important signals to the child about their environment. Recent work shows the predictability of patterns of parental signals on a moment-to-moment timescale sculpts the developing brain during sensitive windows, offering a potential pathway through which early life experiences shape child development. Both experimental non-human animal models and observational human research show sex-specific links between early life exposure to unpredictable patterns of parental sensory signals and aberrant offspring development. The impact of predictability of sensory signals on physical health outcomes, such as BMI, remains unknown. Here …


Coping Self-Efficacy, Acculturation, Gender, Socioeconomic Status, And Perceived Discrimination As Predictors Of Depression Among Nigerian Immigrants In The United States, Olatunde O. Osibote Sep 2025

Coping Self-Efficacy, Acculturation, Gender, Socioeconomic Status, And Perceived Discrimination As Predictors Of Depression Among Nigerian Immigrants In The United States, Olatunde O. Osibote

Walden Dissertations and Doctoral Studies

Nigerian immigrants represent one of the fastest-growing immigrant populations in the United States. Relocating to a new country can be a major source of stress, often increasing individuals’ vulnerability to mental health challenges. While considerable research has examined predictors of depression in the general population and among certain immigrant groups, limited attention has been given to these factors in the context of Nigerian immigrants in the U.S. This study aimed to address that gap by applying Berry’s acculturation theory to investigate predictors of depression within this population. A quantitative, cross-sectional, correlational survey design was used to examine whether acculturation, socioeconomic …


Dinah Between Rape And Seduction: Maarten Van Heemskerck And Renaissance Attitudes Towards Gender And Conflict, Péter Bokody Sep 2025

Dinah Between Rape And Seduction: Maarten Van Heemskerck And Renaissance Attitudes Towards Gender And Conflict, Péter Bokody

School of Law, Humanities and Social Sciences

Marteen van Heemskerck’s Old Testament print series about Dinah, daughter of Jacob, was engraved by Herman Jansz. Muller and published by Gerard de Jode in Antwerp in 1569. In these images Heemskerck reinterprets the Old Testament narrative from a highly misogynistic standpoint, disputing the biblical claim that Shechem raped Dinah. The paper traces the sporadic representations of the episode in print and painting and examines visual strategies that emphasize male vulnerability over the suffering the female victim. Heemskerck’s artistic choices are evaluated in the context of exegetical differences between Martin Luther and John Calvin.


Gene Context Drift Identifies Drug Targets To Mitigate Cancer Treatment Resistance, Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Jessica T Taylor, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Jennifer C Coleman, Joseph S Toker, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Hailong Liu, Tao Jiang, Michael D Taylor, Kui Hua, Jean E Abraham, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson Sep 2025

Gene Context Drift Identifies Drug Targets To Mitigate Cancer Treatment Resistance, Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Jessica T Taylor, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Jennifer C Coleman, Joseph S Toker, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Hailong Liu, Tao Jiang, Michael D Taylor, Kui Hua, Jean E Abraham, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson

Faculty, Staff and Students Publications

Cancer treatment often fails because combinations of different therapies evoke complex resistance mechanisms that are hard to predict. We introduce REsistance through COntext DRift (RECODR): a computational pipeline that combines co-expression graph networks of single-cell RNA sequencing profiles with a graph-embedding approach to measure changes in gene co-expression context during cancer treatment. RECODR is based on the idea that gene co-expression context, rather than expression level alone, reveals important information about treatment resistance. Analysis of tumors treated in preclinical and clinical trials using RECODR unmasked resistance mechanisms -invisible to existing computational approaches- enabling the design of highly effective combination treatments …


Reasons For Maintaining The Classification Of Esmethadone As An Investigational Uncompetitive Nmdar Antagonist Rapid Antidepressant: Reply To Ferré And Michaelides, Sara De Martin, Stefano Comai, Andrea Mattarei, Thomas R Kosten, Frank J Vocci, Charles W Gorodetzky, Marco Pappagallo, Paolo L Manfredi Sep 2025

Reasons For Maintaining The Classification Of Esmethadone As An Investigational Uncompetitive Nmdar Antagonist Rapid Antidepressant: Reply To Ferré And Michaelides, Sara De Martin, Stefano Comai, Andrea Mattarei, Thomas R Kosten, Frank J Vocci, Charles W Gorodetzky, Marco Pappagallo, Paolo L Manfredi

Faculty, Staff and Students Publications

No abstract provided.


Identification Of Cobra And Viper Bites In Southern India Using Enzyme-Linked Immunosorbent Assay, Tejeswara Rao Asuru, Raskin Erusan Rajagopal, Albert Rajendran, Gulistan Parveen, Anushka Das, Pabitha Devi, Swapan K Dasgupta, Shantaraman Kalyanaraman, Prasenjit Guchhait, Perumal Thiagarajan Sep 2025

Identification Of Cobra And Viper Bites In Southern India Using Enzyme-Linked Immunosorbent Assay, Tejeswara Rao Asuru, Raskin Erusan Rajagopal, Albert Rajendran, Gulistan Parveen, Anushka Das, Pabitha Devi, Swapan K Dasgupta, Shantaraman Kalyanaraman, Prasenjit Guchhait, Perumal Thiagarajan

Faculty, Staff and Students Publications

Introduction: Snakebite-related deaths are major concerns in populations worldwide that lack access to medical care. Current treatment of snakebites includes administration of polyspecific and polyvalent heterologous equine antiserum. Swift diagnosis of the species of snake responsible is essential to initiate a specific treatment.

Methods: We generated murine monoclonal and rabbit polyclonal antibodies against the venom of the 3 most common venomous snakes in southern India: the Russell viper, the saw-scaled viper, and the Indian cobra. We developed an enzyme-linked immunosorbent assay to distinguish the snake by analyzing the exudates from the snakebite wound.

Results: Monoclonal antibody EC3 reacts specifically with …


Increased Circulating Th17 Cells And Altered Cd4 T Cell Maturation And Differentiation In Active Tuberculosis With Type 2 Diabetes: A Pilot Study, Paul Ogongo, Yoscelina Estrella Martinez-Lopez, Anthony Tran, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Ilse A. Dominguez-Trejo, Genesis P. Aguillón-Durán, Esperanza M. Garcia-Oropeza, Blanca I. Restrepo Sep 2025

Increased Circulating Th17 Cells And Altered Cd4 T Cell Maturation And Differentiation In Active Tuberculosis With Type 2 Diabetes: A Pilot Study, Paul Ogongo, Yoscelina Estrella Martinez-Lopez, Anthony Tran, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Ilse A. Dominguez-Trejo, Genesis P. Aguillón-Durán, Esperanza M. Garcia-Oropeza, Blanca I. Restrepo

School of Medicine Publications

Introduction: Type 2 diabetes (T2D) is a major risk factor for developing tuberculosis (TB). However, understanding the role of defective T cell responses in T2D and TB has been difficult, largely due to inconsistencies across studies. These discrepancies often stem from T cell subset classification primarily relying on cytokine expression profiles, which may not fully capture the complexity of T cell maturation, differentiation, and function in TB patients with T2D.

Objective and methods: In this pilot study, we sought to identify alterations in phenotypic and ex vivo responses of CD4 T cells to Mycobacterium tuberculosis (Mtb) antigens in people with …


Intestinal Microbiome Changes In Response To Amino Acid And Micronutrient Supplementation: Secondary Analysis Of The Amaze Trial, Monica N Mweetwa, Kazi Ahsan, John Louis-Auguste, Ellen Besa, Joram M Posma, Nathan Mcnulty, Micheal J Barrat, Jeff Gordon, Paul Kelly Sep 2025

Intestinal Microbiome Changes In Response To Amino Acid And Micronutrient Supplementation: Secondary Analysis Of The Amaze Trial, Monica N Mweetwa, Kazi Ahsan, John Louis-Auguste, Ellen Besa, Joram M Posma, Nathan Mcnulty, Micheal J Barrat, Jeff Gordon, Paul Kelly

2020-Current year OA Pubs

Microbial dysbiosis has been linked to environmental enteropathy (EE) and alterations in nutrient absorption; however, compositional modifications following exposure to supplementary nutrients are poorly understood. Here, we report the effect of amino acid and micronutrient supplementation on the gut microbiome of adults with EE. In the AMAZE trial, adults with EE were randomized to amino acids (AA) and/or micronutrients (MM) for 16 weeks in a 2 × 2 factorial design against placebo. Endoscopy was performed before and after intervention, during which duodenal aspirates were collected as well as fecal samples. 16S rRNA amplicon sequencing was performed on both these samples, …


Chemo-Rast With Bortezomib Inhibits Multiple Myeloma Relapse, Anchal Ghai, Alexander Zheleznyak, Christopher Egbulefu, Nicole Blasi, Kvar Black, Rui Tang, Matthew L Cooper, Kiran Vij, Ravi Vij, John Dipersio, Monica Shokeen, Samuel Achilefu Sep 2025

Chemo-Rast With Bortezomib Inhibits Multiple Myeloma Relapse, Anchal Ghai, Alexander Zheleznyak, Christopher Egbulefu, Nicole Blasi, Kvar Black, Rui Tang, Matthew L Cooper, Kiran Vij, Ravi Vij, John Dipersio, Monica Shokeen, Samuel Achilefu

2020-Current year OA Pubs

No abstract provided.


Sagebrush, Wildfire, And Homeowners Associations: Climate Adaptation Opportunities In Summit County, Utah, Rebecca Ivans, Kendall Becker, Wesley Crump, J. Bradley Washa, Lewis Kogan, Scott Hotaling Sep 2025

Sagebrush, Wildfire, And Homeowners Associations: Climate Adaptation Opportunities In Summit County, Utah, Rebecca Ivans, Kendall Becker, Wesley Crump, J. Bradley Washa, Lewis Kogan, Scott Hotaling

All Current Publications

Environmental changes and rapidly expanding suburban developments are amplifying wildfire risk in Utah, including in mixed-sagebrush habitats like those in Morgan, Summit, and Wasatch counties along the Wasatch Back. Wildfire risk to people and structures is especially high in the wildland-urban interface (WUI), where homes and buildings intermingle with undeveloped wildlands and natural vegetation that can fuel wildfire. Much of this urban expansion is occurring in the form of large, dispersed developments managed by homeowners associations (HOAs), which often dictate standards for the homes and properties within their purview. Thus, HOAs can play a critical role in supporting wildfire mitigation …


Kelly's Whole Human Pedagogy: A Conversation With Eric Mortensen, Anna N. Kelly, Eric Mortensen Sep 2025

Kelly's Whole Human Pedagogy: A Conversation With Eric Mortensen, Anna N. Kelly, Eric Mortensen

Journal of Contemplative and Holistic Education

This interview with Eric Mortensen, Professor of Religious Studies at Guilford College, was conducted by Anna Kelly as a part of her study, Whole Human Pedagogy: A Novel Framework for Education Abroad Praxis (2024). In this interview, Kelly and Mortensen discuss holistic pedagogy, largely referencing Mortensen’s experience leading religious studies study abroad programs in Asia. They touch on the themes of embodiment, emotions, relationality, and the purpose of holistic teaching and learning in international education. This interview was conducted with IRB approval.


Electoral Lies And The Broader Problems Of Strict Scrutiny, R. George Wright Sep 2025

Electoral Lies And The Broader Problems Of Strict Scrutiny, R. George Wright

Florida Law Review

States often attempt to regulate political speech in the form of deliberate lies related to ballot initiatives, referenda, candidates, or their political positions. Some courts focus on the various harms of electoral lies, while others focus more on the risks of bias and partisan abuse involved in such speech regulations; the cases are in disarray.

This Article argues, however, that the most important problem underlying this case confusion is inherent in the widely utilized constitutional standard of strict scrutiny. Strict scrutiny typically requires a compelling governmental interest, "narrow tailoring," and some causal relation between the regulation and the compelling interest. …


Practicing Proportionality, William W. Berry Iii Sep 2025

Practicing Proportionality, William W. Berry Iii

Florida Law Review

At the heart of the Eighth Amendment's Cruel and Unusual Punishments Clause are two concepts of proportionality—absolute and relative. Absolute proportionality ("cruel") asks whether the sentence is commensurate with the state's purposes of punishment. Relative proportionality ("unusual"), by contrast, asks whether the sentence is relatively similar to the outcomes of similar cases. Absolute proportionality sets limits on punishment based on the relationship between the punishment and the intended punitive goal; relative proportionality sets limits on punishment based on the sentencing outcomes in similar cases.

In recent years, the United States Supreme Court has used the concept of absolute proportionality to …


Staying Alive: Negotiating Life With The Contamination Of Kitchener Drain., Zein Hassib Sep 2025

Staying Alive: Negotiating Life With The Contamination Of Kitchener Drain., Zein Hassib

Theses and Dissertations

This thesis explores how rural communities in Kafr El Sheikh governorate, Egypt, negotiate everyday life with the contamination of Kitchener Drain, the largest agricultural drain in the central Nile Delta. Drawing on ethnographic fieldwork in three villages at the tail-end end of the drain, the study explores how water contamination shapes social and ecological, social life for farmers living in the catchment of the drain. The thesis situates the farmer’s present experience within the broader history of colonial and modernist national irrigation reforms and developments highlighting how systemic neglect and uneven governance reproduce conditions of vulnerability. At the same time, …


Encountering The Sublime: Early Hermit Lifeways, Visual-Spatial Worlds, And The Global Recluse, James Brown Sep 2025

Encountering The Sublime: Early Hermit Lifeways, Visual-Spatial Worlds, And The Global Recluse, James Brown

The Ozark Historical Review

This paper will assess the degree to which reclusion in the early period can be labeled a global phenomenon and will examine three key areas, the institutional ambits of reclusion, the visual-spatial world of the eremite, and the enduring cultural canon associated with eremitisms across both geographical and temporal distances. In addition, the author will perform an epistemological and phenomenological exercise in deriving humanistic insight from the experiences of recluses, as gleaned through deep consideration of their environments and cultural products.


"The One Bright Spot Where All Else Is Dark And Hopeless." Images Of Class, Race And Culture In Britain's Imperial Education System During The Nineteenth Century, Jeff Grooms Sep 2025

"The One Bright Spot Where All Else Is Dark And Hopeless." Images Of Class, Race And Culture In Britain's Imperial Education System During The Nineteenth Century, Jeff Grooms

The Ozark Historical Review

This paper outlines the ideologies that underpin the language of education, and the relationship between this language and educational policy in Britain and abroad. These topics illustrate that the abstraction of ‘civilization,’ and the themes of ‘darkness’ and ‘light’ that surround it, are an essential part of how nineteenth century sociocultural relations should be studied.


Let Them Speak: The Case For Parental Rights As Educative Speech, Tavia Bruxelles Mcallister Sep 2025

Let Them Speak: The Case For Parental Rights As Educative Speech, Tavia Bruxelles Mcallister

Nebraska Law Bulletin (Selected Issues)

Outlines a case for parental rights as educative speech.


2025-2026 Philharmonia Season Program, Guillermo Figueroa, Jon H. Robertson, Kenneth Amis, Lisa Leonard, Jose Ignacio Diaz, Rishi Gurnani, Noah Suarez, Kyle Mechmet, Dylan Tucker, Alenxander Waguespack, Dion Sellitti, Glen Cortese, Roberta Rust, David Finckel Sep 2025

2025-2026 Philharmonia Season Program, Guillermo Figueroa, Jon H. Robertson, Kenneth Amis, Lisa Leonard, Jose Ignacio Diaz, Rishi Gurnani, Noah Suarez, Kyle Mechmet, Dylan Tucker, Alenxander Waguespack, Dion Sellitti, Glen Cortese, Roberta Rust, David Finckel

Philharmonia

Lynn University Wind Ensemble ("Strange Sounds")

  • Date & Time: September 6, 2025 at 7:30 p.m.
  • Kenneth Amis, conductor

Philharmonia No. 1

  • Date & Time: September 27, 2025 at 7:30 p.m. and September 28, 2025 at 3:00 p.m.
  • Guillermo Figueroa, conductor

Philharmonia No. 2

  • Date & Time: November 7, 2025 at 7:30 p.m. and November 8, 2025 at 3:00 p.m
  • Guillermo Figueroa, conductor
  • Featuring the winners of the 2025 Concerto Competition

Philharmonia No. 3

  • Date & Time: January 31, 2026 at 7:30 p.m. and February 1, 2026 at 3:00 p.m
  • Guillermo Figueroa, conductor

New Music Festival turns 20! A Special Philharmonia …


Don't Count Them Out: Nursing Students With Disabilities – A Scoping Review, Jamille Nagtalon-Ramos, Erin G. Leuthold, Ann Marie Latini, Hana Feldman, Curtis Joseph Pegues Sep 2025

Don't Count Them Out: Nursing Students With Disabilities – A Scoping Review, Jamille Nagtalon-Ramos, Erin G. Leuthold, Ann Marie Latini, Hana Feldman, Curtis Joseph Pegues

International Nursing Research Congress (INRC)

BACKGROUND: Globally, the exclusion of nursing students with disabilities diminishes the diversity and innovation that is crucial for a dynamic, inclusive healthcare system. Nursing students with disabilities represent a vital yet often overlooked segment of the healthcare workforce. Despite legislative milestones such as the Americans with Disabilities Act of 1990, which aimed to dismantle barriers and promote equality, nursing students continue to face challenges such as insufficient accommodations, stigmatization, and discrimination in clinical and academic settings.

PURPOSE: This scoping review aimed to explore the experiences of pre-licensure nursing students with disabilities, as reported in the literature, which is significant to …


Airline Trip Accident Insurance Policy For James Franklin Buchanan, October 1973 Sep 2025

Airline Trip Accident Insurance Policy For James Franklin Buchanan, October 1973

James Franklin “Frank” Buchanan Papers

This Mutual of Omaha scheduled airline trip accident insurance policy covers James Franklin Buchanan for up to forty-five thousand dollars effective October 1, 1973 and names Mrs. James Franklin Buchanan as the beneficiary.


Travel Insurance Record, October 13, 1973 Sep 2025

Travel Insurance Record, October 13, 1973

James Franklin “Frank” Buchanan Papers

This card provides a personal travel insurance record for James Franklin Buchanan in the amounts of five hundred dollars for baggage and ten thousand dollars for death and dismemberment for October 1 through 13, 1973.


Club Boys' Team Demonstration--Pruning A Peach Tree, Undated Sep 2025

Club Boys' Team Demonstration--Pruning A Peach Tree, Undated

James Franklin “Frank” Buchanan Papers

This paper provides objectives for 4-H team demonstrations for pruning a peach tree and goes ono to provide talking points for demonstrations to follow as they work and team demonstration assignments in planting fruit trees.


Services Available To County Agents Through Extension Animal Husbandry, September 3, 1935 Sep 2025

Services Available To County Agents Through Extension Animal Husbandry, September 3, 1935

James Franklin “Frank” Buchanan Papers

This paper provides information on the resources available to county extension agents such as function of specialist, personnel, fields of service, types of assistance, and demonstrating and special assistance. James Franklin Buchanan's name is written across the top of the paper along with the date, September 3, 1935 and his town of residence, Kosciusko, Mississippi.


Spot Buchanan And Tip Smith Birth Announcement, April 8, 1947 Sep 2025

Spot Buchanan And Tip Smith Birth Announcement, April 8, 1947

James Franklin “Frank” Buchanan Papers

This paper announces the births of a set of twins to Spot Buchanan and Tip Smith, presumably the family and neighboring dogs, in Patt's chicken house on April 8, 1947.


Life History, James Franklin Buchanan, February 2, 1991 Sep 2025

Life History, James Franklin Buchanan, February 2, 1991

James Franklin “Frank” Buchanan Papers

James Franklin Buchanan begins his life history with a letter to his daughter, Harriet Ann Buchanan, explaining his reasons for writing the history and offers a genealogy of their family. The history goes on to include anecdotes from various periods of Buchanan's life, including early childhood, high school, college, his work as a County Extension Agent, his time in World War II, his marriage to her mother, Margaret, and his travels. The history also includes photographs of his time overseas during World War II and photocopies of his high school and college diplomas, his parent's marriage license, notable letters he'd …


“Who Wrought It Slowly Long Ago” : Anonymity, The Unnamed, And The Ethical Use Of Objects Found On The Barrow-Downs, Nicholas Birns Sep 2025

“Who Wrought It Slowly Long Ago” : Anonymity, The Unnamed, And The Ethical Use Of Objects Found On The Barrow-Downs, Nicholas Birns

Journal of Tolkien Research

This essay delves into the significance of two objects found by the Hobbits and Tom Bombadil on the Barrow-Downs in J.R.R. Tolkien's "The Lord of the Rings." It considers how the sword found by Merry and the brooch with Tom Bombadil gives to Goldberry have different fates and tell different ethical stories. The essay contrasts the ethical implications of Merry's use of a sword from the Barrow-Downs, which plays a crucial role in the plot, with Goldberry's wearing of a brooch, raising questions about cultural appropriation and the moral reclamation of a artifacts The combination of the importance of these …


Images Of Sacrifice: Religion, Power, And Colonial Ambition In The Americas, Louise Hancox Sep 2025

Images Of Sacrifice: Religion, Power, And Colonial Ambition In The Americas, Louise Hancox

The Ozark Historical Review

The article addresses images of sacrifice from Mesoamerica and the adoption of this imagery during Protestant colonization as a way to limit the Spanish power. The author posits that while initially serving the purpose of demonizing the Spanish Catholic presence in the Americas, the use of this imagery led Protestant powers to assert claims of religious and political superiority over both the Spanish and the indigenous peoples.


Activity Design Principles To Support Engineering Engagement For Families With Preschool-Age Children From Low-Income English-And Spanish-Speaking Communities, Scott A. Pattison, Smirla Ramos Montañez, Viviana López Burgos, Gina Svarovsky, María Quijano, Amy Corbett, Catherine Wagner, Diana Contreras Sep 2025

Activity Design Principles To Support Engineering Engagement For Families With Preschool-Age Children From Low-Income English-And Spanish-Speaking Communities, Scott A. Pattison, Smirla Ramos Montañez, Viviana López Burgos, Gina Svarovsky, María Quijano, Amy Corbett, Catherine Wagner, Diana Contreras

Journal of Pre-College Engineering Education Research (J-PEER)

Existing evidence highlights the significance of family STEM learning experiences during early childhood. However, there is a lack of research specific to early childhood family-based learning in the field of engineering, especially with preschool-age children (three to five years old). To address this gap and inform engineering education programs for young children, we conducted a design-based research study in collaboration with 15 Spanish-and English-speaking families with preschool-age children from low-income communities. Our study aimed to develop and test a series of family-based engineering design activities while also identifying underlying design principles. Guided by an asset-based family learning framework, which acknowledges …


Ai-Driven Generation Of Personalized Movies With Dynamic Character Integration, Gaurav Umeshkumar Gupta Sep 2025

Ai-Driven Generation Of Personalized Movies With Dynamic Character Integration, Gaurav Umeshkumar Gupta

Defensive Publications Series

This disclosure describes a platform that leverages AI to generate personalized cinematic narratives, shifting the user experience from passive viewing to active co-creation. The platform enables users to co-create scripts, integrate their likeness into characters, and experience unique, on-demand movies. The platform operates in two primary modes: a full-generation mode for creating original movies based on user prompts and likeness data, and a variable character movie (VCM) mode where users can insert their likeness into pre-defined variable character slots within professionally produced films. A modular architecture is described that includes an AI orchestration engine, script generation, character integration, video synthesis, …


Amorphous Brensocatib, Prashanth Venukathala, Prashanth Venukathala Sep 2025

Amorphous Brensocatib, Prashanth Venukathala, Prashanth Venukathala

Defensive Publications Series

The present invention relates to the amorphous form of Brensocatib, pharmaceutical compositions comprising the same, and processes for its preparation. More particularly, the invention provides an amorphous preparation that demonstrates improved solubility, dissolution rate, and bioavailability compared to the crystalline form of Brensocatib.