Digital Commons Network^™

Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma

Journal of Food and Drug Analysis

Nanoparticle-based drug delivery system represents one of the challenging strategies suggested to improve anxietydisorder therapeutic approaches, clinic challenges of delayed action, side effect-free designing and poor patientcompliance. Traditional pharmacological agents can increase drug bioavailability and target specific brain regions,whereas nanoparticle-mediated controlled release offers enhanced precision and sustained action. The others in thisreview concentrate on several kinds of nanoparticle, including lipid-based, polymeric-metallic, and responsive nano-particles, their use in anxiety medication. In addition, emphasis is placed on precision medicine that pertain the delivery of treatment based on an individual's genetic, environmental and lifestyle aspects. Also, it is looked into how artificial intelligence …

The Rhythm Of Decline: Circadian Disruption In Neurodegeneration, Jeewanjot Singh, Devinder Kumar, Jasleen Kaur, Amanpreet Singh

Journal of Food and Drug Analysis

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a multifactorial etiology involving genetic,environmental, and metabolic factors. Among these, circadian rhythm disruption has emerged as a crucial but under-explored contributor to disease progression. The circadian system, regulated by the suprachiasmatic nucleus (SCN),controls essential physiological functions such as the sleep-wake cycle, metabolism, and neuroendocrine signaling.Disruption of this system has been increasingly linked to key pathological features of AD, including amyloid-betaaccumulation, tau hyperphosphorylation, and neuroinflammation. This review critically examines the mechanistic roleof circadian misalignment in AD by analyzing studies on sleep disturbances, SCN degeneration, metabolic dysregu-lation, clock gene polymorphisms (BMAL1, CLOCK, PER, …

Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar

Journal of Food and Drug Analysis

Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side …

In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine, Jeewanjot Singh, Devinder Kumar

Journal of Food and Drug Analysis

Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic neuronal loss,oxidative stress, neuroinflammation, and a-synuclein aggregation. Despite advances, current treatments only offersymptomatic relief without altering disease progression. This review aims to evaluate the therapeutic potential of plant-derived phytochemicals in PD through evidence from both in vivo and in vitro experimental models. Key findingsindicate that rodent models (e.g., MPTP, rotenone) and neuronal cell lines (e.g., SH-SY5Y) help replicate PD pathologyand mechanistic insights. Phytochemicals such as baicalein, morin, ferulic acid, and bacopa demonstrate neuroprotectiveeffects via antioxidant, anti-inflammatory, and mitochondrial-stabilizing pathways. Nanotechnology and brain orga-noids further improve translational relevance. In conclusion, …

Factors Influencing The Use Of Gis-Enabled Public E-Participation For Municipal Solid Waste Management, Irene Arinaitwe, Agnes Nakakawa, Gilbert Maiga

The African Journal of Information Systems

Due to rapid global population growth and urbanization, approximately two billion metric tons of waste are generated annually. Municipal solid waste management has become a critical function for urban authorities. However, many urban authorities in low- and middle-income economies cannot provide efficient municipal solid waste management services because of suboptimal stakeholder participation in governance processes and inadequate information exchange. Therefore, this study sought to determine factors that influence the implementation of GIS-enabled public e-participation using Enhanced Adaptive Structuration Theory. A descriptive field study was conducted among staff of municipal authorities and residents in Uganda’s Kampala Metropolitan Area. Data were analyzed …

Vml Special - Models, Gundam, Eva

V Music Magazine

No abstract provided.

Vol. 4 Full Issue

V Music Magazine

No abstract provided.

Daily Eastern News: September 17, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Concomitant Anterior Cruciate Ligament And Medial Collateral Ligament Reconstruction: A Systematic Review, Daniel C Touhey, Francisco N Garcia, Sina Tartibi, Robert H Brophy, Matthew J Matava, Matthew V Smith, Derrick M Knapik

2020-Current year OA Pubs

BACKGROUND: Concomitant anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries are among the most commonly reported injury patterns in high-energy knee injuries. Concomitant ACL and MCL reconstruction (ACLR + MCLR) is indicated in patients with full-thickness tears and persistent valgus laxity.

PURPOSE: To systematically review the literature to identify studies reporting on patients undergoing concurrent primary ACLR + MCLR to better understand current indications, surgical techniques, complications, and outcomes.

STUDY DESIGN: Systematic review; Level of evidence, 4.

METHODS: Under the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, 702 studies published in PubMed, EMBASE, and the …

Galntl5 Binds Galnac And Is Required For Migration Through The Uterotubal Junction And Sperm-Zona Pellucida Binding, Taichi Noda, Reika Uriu, Daisuke Mashiko, Hina Shinohara, Yongcun Qu, Ayumu Taira, Ryan M Matzuk, Duri Tahala, Motochika Nakano, Kimi Araki, Zhifeng Yu, Ying Zhang, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Objective: To review the global impact of the COVID-19 pandemic on stroke care-metrics and report data from a health system in Houston.

Methods: We performed a meta-analysis of the published literature reporting stroke admissions, intracerebral hemorrhage (ICH) cases, number of thrombolysis (tPA) and thrombectomy (MT) cases, and time metrics (door to needle, DTN; and door to groin time, DTG) during the pandemic compared to prepandemic period. Within our hospital system, between January-June 2019 and January-June 2020, we compared the proportion of stroke admissions and door to tPA and MT times.

Results: A total of 32,640 stroke admissions from 29 studies …

Galntl5 Binds Galnac And Is Required For Migration Through The Uterotubal Junction And Sperm-Zona Pellucida Binding, Taichi Noda, Reika Uriu, Daisuke Mashiko, Hina Shinohara, Yongcun Qu, Ayumu Taira, Ryan M Matzuk, Duri Tahala, Motochika Nakano, Kimi Araki, Zhifeng Yu, Ying Zhang, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

More than 20 genes expressed in the male reproductive tract have been identified as essential factors for sperm migration to and through the utero-tubal junction (UTJ), and they are divided into ADAM3-dependent and ADAM3-independent pathways. In parallel, sperm having UTJ migration defects also show impaired binding to the zona pellucida (ZP). Herein, we demonstrate that knockout of Galntl5, encoding a sperm surface protein, causes impaired sperm binding with the UTJ and ZP, and null males have severe infertility. GALNTL5 appreciably disappears in sperm lacking Adam3 or Lypd4, required for ADAM3-dependent and ADAM3-independent pathways, and GALNTL5 binds to N …

Online Inclusivity: Mission And Best Practice, Colin P. Marks, Zoe Niesel

St. Mary's Law Journal

No abstract provided.

Behavioral Responses Of Goose-Beaked Whales (Ziphius Cavirostris) To Simulated Military Sonar, B. L. Southall, R. S. Schick, W. R. Cioffi, Stacy L. De Ruiter, H. J. Foley, C. M. Harris, A. E. Harshbarger, J. E. Joseph, T. Margolina, D. P. Nowacek, N. J. Quick, Z. T. Swaim, L. Thomas, D. M. Waples, D. L. Webster, J. H. Wisse, A. J. Read

University Faculty Publications and Creative Works

We report direct measurements of changes in diving and movement behavior for 53 goose-beaked whales (Ziphius cavirostris) in relation to experimentally controlled mid-frequency (3–4 kHz) active sonar (MFAS) signals. These signals simulate powerful Navy sources that have been associated with multiple mortal stranding events for this species. We deployed a multi-scale combination of tags to monitor individual whales, including 50 long-duration (weeks), coarse-resolution satellite-transmitting tags and 3 short-duration (hours), high-resolution archival depth, orientation, and acoustic tags. We evaluated behavioral responses during 13 experimental trials (9 MFAS; 4 no-MFAS controls), resulting in 72 exposure events; some individuals were exposed in multiple …

Sappho And Erinma In A Garden At Mytilene And The Art History Of Classical Lesbian Love, Addison Cucchiaro

QuaesitUM

No abstract provided.

Comparison Of Two Three-Dimensional Imaging Approaches Used In Fluorescence Microscopy, David Adaway, Chrysanthe Preza

QuaesitUM

No abstract provided.

Illegal Corporate Cultures, Elise Bernlohr Maizel

Duke Law Journal

Culture is a powerful force in corporate compliance. Corporate culture shapes how employees behave, dictating whether, when, and how they follow the law. Cases arising out of cultural failures often involve public harm—plane crashes, poisoned rivers, tainted cancer drugs, and collapsed mines. Before these awful outcomes, however, the corporations that caused these harms fostered cultures that permitted the disregard of legal commands and public commitments. Managers disparaged safety regulations. Messages about profits and production drowned out messages about compliance and safety. Yet, there is a gap between all we know about the power of culture and our understanding of corporate …

Smart Dressings Accelerating Wound Healing With Tranexamic Acid-Infused Aligned Electrospun Nanofibers: In Vitro And In Vivo Assessments, Samar A. Salim, Abdullah Elbadry, Eman Gomaa, Mennatullah Faisal, Elbadawy A. Kamoun

Nanotechnology Research Centre

The development of advanced wound dressings capable of accelerating healing and achieving effective hemostasis remains a critical challenge in managing traumatic and surgical wounds. This study reports the fabrication and comprehensive evaluation of a novel multilayered, sandwich-structured nanofiber scaffold composed of Tranexamic acid (TXA), chitosan (CS), polyvinyl alcohol (PVA), L-arginine, and polylactic acid (PLA) for biodegradable wound dressing applications. Using sequential electrospinning, a four-layered scaffold was developed as a smart wound dressing, comprising an immediate-release TXA-CS-PVA layer for rapid clotting, a hydrophobic PLA barrier layer for protection, a sustained-release L-arginine-PVA layer to promote tissue regeneration, and a final PLA protective …

On Good Terms: Pathways To Decolonizing Science-Appropriated Indigenous Terminologies In Arctic Research, Stanislav Saas Ksenofontov, Vera Kuklina, Alexander Kholodov, Andrey Petrov

Faculty Publications

Many western scientific disciplines adopted Indigenous Knowledge and terminology without deference to or understanding of the original meanings and values attached to Indigenous terms and concepts. This form of scientific appropriation has become a serious barrier to efforts of decolonizing Arctic research. The notion of Alaas is an example of such appropriation by the western science-based system of Indigenous knowledge about human–nature relations. This paper aims to discuss the term Alaas as it is conceptualized in both western science and Indigenous knowledge. The paper will explore the development of “alas” as an international permafrost science term and Alaas as an …

Slowing The Burn: Incentivizing Safer Development Through Wildfire Hazard Mapping, Meghan Hodges

Duke Law Journal

Climate change has accelerated the frequency and severity of natural disasters globally and wildfires are no exception. In part, wildfires have intensified due to climate change, short-sighted fire suppression policies, and the rapid influx of people and development in hazardous regions. Like other natural disasters, wildfires will continue to pose an ever-increasing threat to communities nationally. And the federal government's default approach of providing aid after disaster strikes will only continue to become more unsustainable as climate change worsens. Yet, proactive measures that exist to mitigate risk—such as hazard mapping and financial assistance to support adaptation and resilience at the …

Bard1: A Friend Or Foe In Pancreatic Ductal Adenocarcinoma?, Lily Zekavat, Aditi Jain

Department of Surgery Faculty Papers

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid malignancy with poor overall prognosis and limited response to standard treatments. Growing interest in the modulation of DNA repair mechanisms, including the homologous recombination (HR) repair pathway, has opened new avenues for therapeutic development. BARD1 (BRCA1-Associated RING Domain 1) plays a complex role in tumor biology, functioning either as a tumor suppressor or as an oncogenic driver, depending on isoform expression, cellular context, and regulatory environment. In this review, we examine the dual roles of BARD1, focusing on its regulation and paradoxical activities in PDAC. We summarize evidence that BARD1 and BARD1 …

Preserving Cultural Identity In Multi-Function Real Estate Developments, Khloud Khalid Eldamshiry

Architectural Engineering

The proliferation of multi-function real-estate developments (MRD) frequently leads to the erosion of unique architectural identity (AI), threatening the historical and cultural character of urban areas. This research addresses a critical gap in understanding how new developments can effectively preserve and leverage local cultural heritage. Grounded in the theoretical understanding of heritage-led urban regeneration, this study aims First, to identify the specific architectural elements and design strategies crucial for preserving cultural sustainability (CS) in multi-function real estate projects; and second, to quantify the perceived impact of these strategies on local community engagement and economic viability. The hypothesis posits that multi-function …

Burdens Of Proof In Criminal Procedure, Eve Brensike Primus

Duke Law Journal

The Supreme Court's haphazard approach to allocating burdens of proof in criminal procedure has created a system in which constitutional rights can be rendered meaningless simply because defendants are required to prove things they cannot possibly know. Even though allocations of the burden of proof often drive litigation outcomes, the Court has failed to establish clear burden allocation structures for cases arising under the Fourth, Fifth, Sixth, and Fourteenth Amendments, leaving lower courts split about how to allocate the burdens. When the Supreme Court does allocate burdens, it often does so without explanation or consideration of key factors. Recent Supreme …

Inside Awamc, October 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on the work of hospitalists.

Inside Awamc, December 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces a biorepository for the Aurora Health Care system.

Inside Awamc, January 2010, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature store on a stroke rehabilitation patient.

This is the last issue of this publication that the library has.

Inside Wamh, January 2007, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue includes announcements of programs and services.

Inside Wamh, April 2007, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue includes announcements of programs and services.

Inside Wamh, October 2007, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on a new therapy dog at the hospital, and new initiatives in Food Services around recycling, composting, and increasing the amount of fruits and vegetables offered.

Internet Of Batteries: An Integrated System Of Battery Health Surveillance System For Electric Vehicles (Evs), Ayodeji Akinsoji Okubanjo, Ignatius Kema Okakwu, Alexander Akpofure Okandeji, Oluwasogo Emmanuel Seun, Olusesi Ayobami Taiwo

AUIQ Technical Engineering Science

Progress in storage technologies is vital to the efficiency of electric vehicles in combating climate change. The automobile industry’s transition to electric mobility has significantly increased the demand for battery storage systems (BSS) in terms of performance, reliability, monitoring, and evaluation of key parameters. However, poor safety and monitoring strategies for battery storage systems in electric vehicle applications pose an increasing threat to the vehicles’ sustainability and mobility. This calls for intelligent battery storage monitoring systems to mitigate carbon footprint and preserve battery lifespan of electric vehicles. This paper focuses on battery storage sustainability in electric vehicles with special emphasis …

Development Of Interactive Learning Media Based On Illustrated Word Cards To Improve Students' Reading Skills, Laila Nadya, Riris Nurkholida Rambe

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

To improve the reading skills of first-grade elementary school students in Indonesian, particularly in relation to reading, this project aims to create picture card-based learning materials. The five steps of the ADDIE development model, namely analysis, design, development, implementation, and evaluation, were used in the research and development (R&D) process. Pretests and posttests, expert validation, questionnaires, interviews, and observations were some of the methods used to collect data. Experts in content, media, and language verified the media that had been created, and feedback from teachers and students assessed its usefulness. With a feasibility rating of 94% from media experts, 91% …