Digital Commons Network^™

Development Of A Novel Kt Tool For Parents Of Children With Idd Seeking Emergency Care, Shannon Scott, Sarah Elliott, Hannah M. Brooks, Gwen Erdmann, Lisa Hartling

International Nursing Research Congress (INRC)

Background: Children with intellectual developmental disorders (IDD) are generally defined as those under 18 years old who have conditions that can adversely impact their physical, intellectual, and/or emotional development. Taking a child to an emergency department (ED) is often unexpected and stressful for the parents and child. Children with IDDs are among the highest users of emergency health care services in their age group (3), with complex and challenging ED experiences. Digital knowledge translation (KT) tools can effectively share experiences and health information while addressing the learning needs of parents.

The aim of this study is to report on the …

Antimicrobial Resistance (Amr): Policy And Practice Challenges In West Africa, Charles Kwanin

International Nursing Research Congress (INRC)

Antimicrobial resistance is a complex global health challenge we face now in our world. There are global solutions developed to tackle this challenge. To explore the challenge, Ghana and Liberia were the countries of focus. Using policy analysis of data from the Tripartite Antimicrobial Resistance Country Self-Assessment Survey (TrACSS) by the World Health Organization data Global database as of 2022 on AMR an analysis of the various policies both governments have been implemented was conducted. A semi-structured interview was conducted among three selected from each country. The results of this study indicate that AMR is a global health security challenge; …

Fish Oil And Vernonia Amygdalina Leaves-Supplemented Biscuits Increased Insulin Secretion And Suppressed Pro-Inflammatory Cytokines In Type 2 Diabetic Wistar Rats, Omolola Soji-Omoniwa, Uthman Olanrewaju Abdulazeez, Christfavour Oluwaseyi Oloba, Samuel Olajuwon Kolawole, Johnson Opeyemi Olayinka, Emmanuel Olorunleke Oludipe, Anuoluwapo Faith Ajediti, Habib Tajudeen Yusuf

Al-Bahir

This research determined the effect of fish oil and Vernonia amygdalina-enriched biscuits (FVSB) on insulin sensitivity and inflammatory cytokines in type 2 diabetic rats. Forty-nine male rats were grouped into seven, i.e. A-G. Type 2 diabetes (T2DM) was induced in groups B-G by administering 230 mg/kg body weight [BW] NAD (ip) and 65 mg/kg BW streptozotocin (ip). Group A represented the control (Non-diabetic + unsupplemented biscuit), B (untreated diabetic), C (diabetic + 120 mg/kg BW metformin), D-F (diabetic + FVSB at 1g, 2g and 3g leaf inclusion respectively), and G (diabetic + conventional biscuit). The experiment lasted 35 days, …

Novel Insights Into Wdfy3 Pathogenicity: A Case Report Of Microcephaly And Epilepsy, Pietra Spinardi, Gabriel Bordignon, Gustavo Moura Da Mata Machado Ferreira Pinto, Monica Alexandra De Conto, Daniel Almeida Do Valle

Journal of Pediatric Genetics

WDFY3 is a critical gene involved in neuronal migration, autophagy, and vesicular transport during brain development. Pathogenic variants in WDFY3 gene are associated with a range of neurodevelopmental disorders, including autism spectrum disorder ASD, epilepsy, and intellectual disability. We present here a case of a female child with a de novo heterozygous WDFY3 variant (c.10189A>T; p.Thr3397Ser), identified through whole exome sequencing. The patient presented with microcephaly, global developmental delay, and epilepsy. Despite the presence of microcephaly, neuroimaging (MRI) revealed no significant abnormalities, a finding consistent with previous reports. Previous studies suggests that WDFY3 haploinsufficiency alters synaptic density and mitochondrial …

Systematic Exploration Of Trpv6 Variants In Pancreatitis: Unraveling Genetic Associations And Pathophysiological Insights Through Comprehensive Systematic Review And In-Silico Analysis, Omar Alomari, Rumeysa Yegin, Muhammed Edib Mokresh, Ghazaleh Kokabi Ghahremanpour, Nurullah Komurcu, Elif Nur Ari, Magda Wojtara, Ali Karaman, Abdulqadir J. Nashwan

Journal of Pediatric Genetics

Background and Aims: The transient receptor potential vanilloid subfamily member 6 (TRPV6), a calcium-selective channel, is crucial for intracellular calcium (Ca2+) transport, impacting the maintenance of Ca2+ homeostasis in the pancreas. Variants in the TRPV6 gene have been associated with disruptions in calcium balance, potentially contributing to chronic pancreatitis (CP). This systematic review aims to unravel the connections between TRPV6 gene variants and pancreatitis, with a particular focus on CP. Additionally, we conducted an in-silico co-expression analysis to explore the interrelationships among validated genetic variants associated with pancreatitis pathophysiology and TRPV6 gene variants . Methods: A comprehensive literature search was …

Bard College: An Ecosystem Of Engagement, Jonathan Becker

Journal of Community Engagement and Higher Education

Despite its moderate size and rural location, Bard’s civic engagement efforts resonate locally, nationally, and internationally, and have significant public policy impacts. Bard has achieved success by making engagement central to its institutional mission, viewing liberal arts and sci-ences education as both a means and an end of civic engagement efforts, and forging an “ecosystem of engagement” that encourages organizational engineers, links student-led and in-stitutional initiatives, and unites a network of partners across the globe.

Advancing Sustainable Structural Solutions: Hemp Fiber-Reinforced Polymer (Hfrp) Reinforcement Bars For Concrete Applications Through Material Selection, Simulation, And Pathways For Future Development, Thomas Cadenazzi, Busra Keles

Journal of Sustainable Construction Materials and Technologies

This paper investigates innovative Hemp Fiber-Reinforced Polymer (HFRP) rebars as a sustainable alternative to conventional Carbon Steel (CS) and Glass Fiber-Reinforced Polymer (GFRP) rebars used as reinforcement in concrete structures. The feasibility of HFRP rebars is assessed, focusing on mechanical properties and sustainability advantages. A virtual tensile test on a modeled M19 HFRP rebar, conducted using Autodesk's Fusion 360, demonstrates tensile strength comparable to CS 235 and greater environmental sustainability than GFRP, despite a slight reduction in stiffness. The study also considers the potential of graphene fiber integration to enhance mechanical properties, underscoring HFRP's adaptability. Findings suggest that HFRP rebars, …

Dairy And Food Science Student Newsletter, September 23, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

Humanization Of Cd47 Enables Development Of Functional Human Neutrophils Via Postirradiation Remodeling Of The Bone Marrow, Esen Sefik, Liang Shan, Et Al.

2020-Current year OA Pubs

Murine and human immune systems differ significantly, particularly within the myeloid lineage. Humanized mice, generated by transplanting human hematopoietic stem, progenitor cells into genetically modified mice, are invaluable to study human immune development and function in vivo. However, a major limitation of current models is suboptimal myelopoiesis, particularly lack of functional human neutrophils, hampering the modeling of human immune responses and chronic diseases. Here, we describe a humanized mouse model, named MaGIC for genes replaced, in the

Beyond Personal Responsibility: Government Support For The Substantive Human Condition, Martha T. Mccluskey

Contributions to Books

Government protection against systemic harm to human well-being is stymied by the liberal idea that power is most legitimately wielded by autonomous individuals taking personal responsibility for their substantive well-being. Instead, a robust vision of democracy and socioeconomic justice requires grounding legitimate power in institutional responsibility, replacing the formal individual actor of liberal theory with the universally embodied, embedded human subject developed in Martha Fineman’s Vulnerability Theory. This chapter connects the message of personal responsibility in neoliberal US welfare reform policies to rationales defending the government’s failure to alleviate systemic human harm in the 2008 financial crisis and the accelerating …

Mt1-Mmp Inhibition Rejuvenates Ageing Brain And Rescues Cognitive Deficits In Obesity, Pallavi Asthana, Liguo Li, Lin Lu, Jiayan Wu, Shuo Zhang, Ningning Li, Sheung Kin Ken Wong, Susma Gurung, Yijing Zhang, Yuwan Lin, Yufeng Peng, Zongtang Xu, Kui Ming Chan, Lixiang Zhai, Aiping Lyu, Zhao-Xiang Bian, Xin Ge, Ashok Iyaswamy, Min Li, Ya Su, Zhongjun Zhou, Pingyi Xu, Hoi Leong Xavier Wong

The Brown Foundation: Institute of Molecular Medicine

Obesity has been linked to an increased risk of cognitive impairment and dementia in later life. Although aging and obesity are both associated with cognitive decline, it remains unclear how they interact to affect cognitive function across the lifespan and how brain function might mediate their relationship with cognition. Our previous findings and other studies have shown that membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14), which increases with age, regulates energy homeostasis. Inhibiting MT1-MMP improves insulin sensitivity, reduces body fat, and lowers serum cholesterol. Here, we demonstrate that MT1-MMP links neuroinflammation to cognitive decline in aging and obesity. Inflammatory responses in the …

Sars-Cov-2 Nsp13 Interacts With Tead To Suppress Hippo-Yap Signaling, Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin

Faculty, Staff and Students Publications

The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed RNA sequencing data from human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and SARS-CoV-2-infected human lung samples, and observed a decrease in YAP target gene expression. In screening SARS-CoV-2 nonstructural proteins, we found that nonstructural protein 13 (NSP13), a conserved coronavirus helicase, inhibits YAP transcriptional activity independent of the upstream Hippo kinases LATS1/2. Consistently, introducing NSP13 into mouse cardiomyocytes suppresses …

Atrial Fibroblast-Derived Macrophage Migration Inhibitory Factor Promotes Atrial Macrophage Accumulation In Postoperative Atrial Fibrillation, Joshua A Keefe, Jose Alberto Navarro-Garcia, Shuai Zhao, Mihail G Chelu, Xander Ht Wehrens

Faculty, Staff and Students Publications

New study: Blocking MIF protein prevents irregular heartbeats after surgery by reducing harmful immune cell buildup in the atria.

Dietary Methionine Restriction Primes T Cell Metabolism For Activation And Tumor Inhibition And Enhances The Efficacy Of Immune Checkpoint Blockade, Xiaoqing Qing, Binita Chakraborty, Panpan Liu, Sandeep Artham, Patrick K Juras, Dongyin Guan, Kristen E Pauken, Ching-Yi Chang, Xia Gao

Faculty, Staff and Students Publications

The proliferation of many cancer cells is methionine dependent and dietary methionine restriction (MR) has shown anti-tumor effects in a wide variety of immunodeficiency preclinical models. Yet, whether MR exerts an anti-tumor effect in the presence of an immune-competent background remains inconclusive. Accumulating evidence has shown an essential role of methionine in immune cell differentiation and function. Thus, competition for methionine between tumor cells and immune cells in the tumor microenvironment may drive tumor growth and tumor response to therapy. Here, we aim to define the impact of MR on tumor growth and associated immunity. We first assessed the effect …

Sources, Distribution And Ecological Risk Assessment Of Polycyclic Aromatic Hydrocarbon In Sediment Of Tigris River, Iraq, Shahad R. Zaki, Maysoon Hassan Meshjel, Abdul Hameed M.J. Al-Obaidy

Baghdad Science Journal

Sediment samples were collected from five sites at Tigris River from Baghdad to Wasit Governorates River from December 2021 to November 2022. Sixteen polycyclic aromatic hydrocarbons (PAHs) in these sediment samples were analyzed. The results show that the total PAH concentrations ranged from 957.37 to 1805.05 μg/kg dry weight (dw) with mean values of 1368.034 μg/kg. Furthermore, the high molecular weight compounds (four, five, and six rings) of PAH in the analyzed sediment samples suggest that combustion sources such as fuel, gasoline, and vehicle emissions are the primary sources of PAHs in the environment. The sediment quality guidelines …

A Numerical Approach To Time-Space Fractional Stochastic Diffusion Equation, Archana Mourya, Kalyanrao Takale, Shrikisan Gaikwad

Baghdad Science Journal

The primary objective of this paper is to propose a Crank-Nicolson scheme tailored to analyze a time-space fractional stochastic diffusion equation subject to additive noise. Using the Caputo definition for time fractional derivatives and the shifted Grunwald-Letnikov definition for space fractional derivatives, a fractional order Crank-Nicolson finite difference scheme is devised to obtain a numerical solution. Considerable attention has been paid to examining the stability and convergence properties of this fractional order Crank-Nicolson method. To validate the effectiveness of the developed method, a comprehensive investigation using a test problem is conducted to assess its accuracy. The study harnesses the power …

Proactive Siem-Based Framework For Cyberattack Monitoring And Classification, Zeyad Safaa Younus, Mafaz Alanezi

Baghdad Science Journal

Cybersecurity is a crucial aspect of modern information technology, encompassing safeguarding computer systems, network resources, and information from cyberattacks. Wazuh is an open-source security information and event management (SIEM) technology for real-time attack detection but faces challenges like log analysis complexity and alert overloading, which raises the number of false-positive alerts and affects accuracy. This paper presents three hierarchical models for real-time attack prediction using Wazuh to gather real-time dataset from various network endpoints and then preprocess them using a variety of tools. Subsequently, mutual-information, principal component analysis (PCA), and independent component analysis (ICA) are utilized for feature reduction and …

Av-Efficapsnet Based Deep Neural Network Model For Automated Detection Of Hypertensive Retinopathy In Fundus Image, Sowmiya R, Kalpana R

Baghdad Science Journal

Hypertensive Retinopathy (HR), a serious consequence of systemic hypertension, manifests through specific changes in the retinal vasculature observable in fundus images. There might not be any symptoms or complaints at the early stage of systemic hypertension. The complication of the systemic hypertension sets in vital organs of the body including the eyes over time. An automated method for HR detection can help in early detection and enhance diagnosis and management and thus reduce the risk of severe ocular and systemic complications. Subjective evaluation of the retinal images by ophthalmologist is the conventional diagnostic method, which might be inconsistent and time …

Forecasting And Predictive Model Building For Heart Failure Data Using Machine Learning Techniques, K Sukanya, Khadar Babu Sk

Baghdad Science Journal

Heart failure is a critical medical condition with significant global morbidity and mortality rates. Early prediction of Heart Failure risk is paramount for timely intervention and improving patient outcomes. Leveraging the power of machine learning, this study conducts an in-depth examination of Heart Failure prediction using a comprehensive dataset. The dataset encompasses clinical, demographic and laboratory data of Heart Failure patients. A variety of machine learning techniques like logistic regression, decision tree and random forest are harnessed to construct predictive models for Heart Failure. The analysis integrates essential data preprocessing techniques like missing value imputation, feature scaling and feature selection …

Optimizing Webrtc Video Conferencing Platform Assisted By Sdn Approach, Sanabil A. Mahmood, Naktal Moaid Edan, Monjikheralla Monjikheralla

Baghdad Science Journal

To support the best path among several paths, the network must choose the path with the best path to support Quality of Service (QoS), especially for real-time interactive video applications, such as distance learning and video conferencing. As long as the chosen routing protocol path is fixed by network topologies such as integrated services (ISs), which may not provide the highest possible performance. In addition, software-defined networking (SDN) intelligence with web-based real-time communications (WebRTC) can determine the most efficient data packet routing, which reduces latency and improves real-time communications. The main objective of this paper is to build and implement …

Next-Gen Tools In Cancer Neuroscience, Vera Thiel, Debpali Sur, Caroline C Picoli, Tamara Mcerlain, Katalina Couto, David J Simon, Yuan Pan, Karen Olivia Dixon, Rajan P Kulkarni, Sebastien Talbot, Alexander Birbrair

Faculty, Staff and Student Publications

The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innovative optical electrophysiological approaches, optogenetics, chemogenetics, engineered viruses, and new methods for visualizing neuronal activity. Collectively, these technologies are revolutionizing how we investigate, manipulate, and characterize distinct components that contribute to the nervous system-cancer interface. In the present review, we discuss the key technologies that are closing the gap between oncology and neuroscience, highlighting the innovations that are propelling the cancer neuroscience field forward.

Rna/Dna-Binding Protein Tdp43 Regulates Dna Mismatch Repair Genes With Implications For Genome Stability, Vincent E Provasek, Albino Bacolla, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Issa O Yusuf, Vikas H Malojirao, Velmarini Vasquez, Gavin W Britz, Guo-Min Li, Zuoshang Xu, Sankar Mitra, Ralph M Garruto, John A Tainer, Muralidhar L Hegde

Faculty, Staff and Student Publications

TDP43 is an RNA/DNA-binding protein increasingly recognized for its role in neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As characterized by its aberrant nuclear export and cytoplasmic aggregation, TDP43 proteinopathy is a hallmark feature in over 95% of ALS/FTD cases, leading to detrimental cytosolic aggregates and a reduction in nuclear functionality in neurons. Building on our prior work linking TDP43 proteinopathy to the accumulation of DNA double-strand breaks (DSBs) in neurons, the present investigation uncovers a novel regulatory relationship between TDP43 and DNA mismatch repair (MMR) gene expression. Here, we show that TDP43 depletion or overexpression …

Quantum Chemical Calculations On Corrosion Inhibition Efficacy Of Benzodiazepines On Mild Steel In Acid Medium, Maimoonah Khalid Qasim

Baghdad Science Journal

One of the most important factors in preventing mild steel from deteriorating in acidic conditions is corrosion inhibition. This study examined the anti-corrosion properties of two benzodiazepine compounds, namely Dimethyl-[4-(4-phenyl-2,3-dihydro-1H-benzo[b][1,4] diazepin-2-yl] L-[4-(4-methyl-2,3-dihydro-1H-benzo[b][1,4]diazepin-2-yl)-phenyl] and dimethy-amine (DPBD) and toluene (DMBD), employing density functional theory (DFT)-based quantum chemical computations. Determining the corrosion inhibitors’ active locations and contrasting their efficacy were the goals. The probable active sites of DPBD and DMBD as corrosion inhibitors were identified by the DFT calculations. The total corrosion inhibition performance of these two compounds did not significantly differ, according to the data. However, a slightly better performance was observed …

Study Of Serum Interleukin-33 And Soluble St2 Levels, And Hla-B27 Typing In Iraqi Patients Of Ankylosing Spondylitis, Faris Ali Khdur, Hanaa N. Abdullah, Mayada Noori Iqbal

Baghdad Science Journal

Ankylosing spondylitis (AS) is a type of arthritis that causes inflammation in the joints and ligaments of the spine. The current study aimed to determine the level of serum interleukin-33 (IL-33), soluble stromelysin-2 (sST2) interleukin, and HLA-B27 typing among Iraqi AS patients. The whole blood samples of the patients were collected from medical hospitals in Baghdad city. The ELISA technique was used to measure the serum levels of IL-33 and sST2, and the HLA-B27 typing was performed by sequence-specific primer PCR (SSP-PCR). The patients were divided into patients newly diagnosed with the disease and patients receiving biological treatment (etanercept) in …

Impacts Of Stevia Rebaudiana Leaf Aqueous Extract On Some Physiological Parameters And Fertility In Male Albino Mice, Zainab K. Altmimi

Baghdad Science Journal

The objective of the work is to examine the impacts of Stevia leaf aqueous extract, after chronic administration (60 days), on some physiological aspects and fertility in male albino mice. .twenty-four adult e mice were categorized into four groups, each involving six animals. Three treatment groups were separately exposed to three respective concentrations of the extract (25, 50, and 100 mg/kg), he remainder is a control group. The animals were given daily oral doses of 0.1 ml/ 10 gm body weight of the group-respective extract concentration for 60 consecutive days. Several physiological and fertility-related parameters were tested based on the …

Design And Implementation Of Pulse Laser Deposition Device For Plastic Optical Fiber, Ihssan A. Kadhim, Anwaar A Al-Dergazly, Sameer Khudhur Yaseen

Baghdad Science Journal

In this work, a pulse laser deposition device was fabricated to synthesize nano-coated plastic optical fiber for sensing application. a plastic optical fiber of 1000 μm diameter, coated with different materials such as aluminum and titanium oxide. Using a field emission scanning electron microscope (FESEM), the coated samples’ shape, surface properties, and chemical makeup were verified., an energy dispersion X-ray (EDX), UV-vis absorption spectroscopy, atomic force Microscope (AFM). The cross section EDX indicated that, a small amount of uniform distribution of aluminum and titanium on the surface of plastic optical fibers. The FESEM surface morphology of TiO₂ coated …

Exponential Domination Of Some Chemical Structures In Reduced (A, B)-Ka Indices, Anjaneyulu Mekala, U Vijaya Chandra Kumar, R. Murali

Baghdad Science Journal

Mathematical modeling with the help of numerical coding of graphs has been used in different fields of science, especially in chemistry for the studies of molecular structures. A special type of graph invariant called the topological index is the collection of data on algebraic graphs and provides a mathematical way to understand chemical structural features. In chemical graph theory, the topological index is a type of molecular descriptor calculated based on the graph of chemical compounds. Topological indices help us collect information about algebraic graphs and give us a mathematical approach to understand the properties of algebraic structures. With the …

Laplacian Energy And Eccentricity Based Energy For Cross Monic Zero Divisor Graph Associated With Commutative Rings, Sarathy Raja, Ravi Sankar Jeyaraj

Baghdad Science Journal

For a commutative ring, a cross monic zero divisor graph is discussed, whose vertices are nonzero zero divisors of the commutative ring, then the two vertices x and y are adjacent if and only if xy = 0. Sum of absolute auxiliary eigenvalues of Laplacian matrix of a simple graph is known as Laplacian energy of a simple graph. Eccentricity sum matrix of a graph is a positive matrix, whose entries are sum of the eccentricities of two vertices and 0 for diagonals of the eccentricity sum matrix. Then the sum of absolute eigenvalues of eccentricity sum matrix is known …

Assessing The Sustainable Circular Fashion Supply Chain As A Model For Achieving Economic Growth In The Global Market, Andrew P. Burnstine, Raouf Ghattas

Faculty and Staff Publications & Presentations

The fashion industry faces a critical sustainability crisis, contributing up to 10% of global carbon emissions and generating 92 million tons of textile waste annually. The study highlights the complex interplay of material flows, business models, power structures, and cultural mindsets, presenting a multi-scaled framework for advancing cleaner production and circularity in one of the world’s most resource-intensive sectors. This study proposes a transformative model for circular bioeconomy in fashion, integrating systems-change theory, degrowth economics, and emotional durability. Through case studies, including Patagonia, Eileen Fisher, and EU policy frameworks, the paper demonstrates how circular strategies can reduce waste, extend product …

Team Approach To Increase Staff Happiness, Cindy Dancel, Chereeka Garner, Jason D. Phillips, Christopher Saclolo

Faculty Scholarship and Creative Works

"Having fun isn't hard when you've got a library card" (Arthur Read) but can be quite a challenge when you work at the library. Check out this session to discover ways an employee driven, administration supported library committee has worked to increase employee morale, build community among new and veteran library staff members, and provide off campus networking opportunities with minimal planning, building wide collaboration, and budget limitations.