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Network Pharmacology And Molecular Docking Analysis Of Nephelium Lappaceum (Rambutan) Compounds As Potential Alternative Treatments For Lung Cancer, Dwi Utami, Muhammad Farid, Rachma Greta Perdana Putri

Makara Journal of Science

Introduction: Lung cancer is characterized by high mortality rates and poor prognosis, further requiring alternative therapies owing to the adverse effects of conventional chemotherapy. Rambutan (Nephelium lappaceum L.) has antimicrobial, antiproliferative, and antioxidant properties and can cure cancer. Method: Compounds from rambutan peel were identified through PubChem and analyzed for physicochemical properties using SwissADME. Target proteins were identified using SuperPred and compared with lung cancer–related proteins from GeneCards via Venny. Protein interactions were examined and visualized using STRING and Cytoscape, respectively. Protein activity was analyzed using WebGestalt, and docking simulations were performed using Autodock 4.2.6. Result: Physicochemical analysis of …

Neutrosophic Set Model For Controlling Electronic Waste Requirements Management Policies To Minimize Ecological Impact And Improving Resilience And Sustainability, Mohamed Abouhawwash, Nitin Mittal, Sudeep Tanwar

Neutrosophic Systems with Applications

The growing issue of electronic waste (e-waste) necessitates management approaches that promote sustainability and resilience while reducing environmental effects, particularly considering global disruptions and pressure on manufacturers to implement extended producer responsibility laws. There is a research gap in our knowledge of the link between sustainability and resilience since most of the literature currently available on e-waste management focuses on either operational efficiency or sustainability. This study proposes multi-criteria decision making (MCDM) methodology for controlling electronic waste requirements management policies to minimize ecological impact and improving resilience and sustainability. We use the EDAS methodology to rank the alternatives. The criteria …

Application Of Dematel Based On Bipolar Neutrosophic Sets For Sustainable Agriculture Practices, Lazim Abdullah, Nor Liyana Amalini Binti Mohd Kamal

Neutrosophic Systems with Applications

The development of natural capital is a fundamental objective within sustainable agricultural systems, where the optimization of both crop and livestock production is vital to addressing global food demands. Despite this imperative, major agricultural sectors such as paddy and rubber production, often fall short of satisfying consumption needs. This study aims to identify and prioritize the most influential criteria for sustainable agriculture using the Bipolar Neutrosophic Set-based Decision-Making Trial and Evaluation Laboratory (BNS-DEMATEL) method. Expert evaluations were elicited from five agricultural specialists using linguistic assessments to analyze the performance and interdependencies among sustainability criteria. Computational analyses were conducted using MATLAB …

Some New Three-Term Conjugate Gradient Methods For Riemannian Optimization With Application To The Gough-Stewart Platform, Nasiru Salihu, Poom Kumam, Lin Wang, Sani Salisu

Mathematical Modelling and Numerical Simulation with Applications

Three-term conjugate gradient (TTCG) methods have been extensively studied for optimization within Euclidean geometry, with some inherently satisfying the sufficient descent property, thus enhancing their theoretical superiority. However, other TTCG methods have been developed that incorporate restarting the search direction, simplify the steepest descent approach, or rely on the convexity assumptions of f to establish their convergence results. This paper introduces the Riemannian three-term conjugate gradient (RTTCG) methods. The search direction in these RTTCG methods consistently satisfies the sufficient descent condition, regardless of the line search employed, and does so without requiring a restart mechanism. By utilizing retraction and vector …

The Effect Of Pesticide Exposure On Metabolic Syndrome: An Epidemiological Analysis In An Agricultural Population, Putri Arida Ipmawati, Rusmiati Rusmiati, Suharno Suharno, Tommy Denie Irianto, Alfino Validita Sidiq, Abentin Estim, Slamet Wardoyo

Media Kesehatan Masyarakat Indonesia

Metabolic syndrome, characterised by hyperglycaemia, dyslipi-daemia, hypertension, and central obesity, is a global health problem, and exposure to pesticides is an important risk factor for agricultural workers. This study aims to analyse the effects of pesticide exposure, sociodemographic factors, and Personal Protective Equipment (PPE) usage behaviour on glucose levels, HDL, and LDL in farmers in Kubu Raya District, West Kalimantan. A cross-sectional study was conducted on 60 farmers selected using stratified random sampling. Data were collected through structured interviews, fasting blood tests, and analysed using the chi-square test with a significance level of 95%. The results showed a high prevalence …

Effect Of Dietary Supplementation Of Symbiotic, Prebiotics And Probiotics On Conformation Of Teats In Rabbits, Saqib Kakar, Allah Bux Kachiwal, Saeed Ahmed Soomro, Akeel Ahmed Memon

Journal of Bioresource Management

This study evaluated the effects of dietary supplementation with prebiotics, probiotics, and symbiotics on the reproductive and physiological performance of New Zealand White rabbits, emphasizing teat conformation. Forty-eight rabbits were divided into four groups: control (a), prebiotics (b), probiotics (c), and symbiotics (d). During the first parity, teat conformation varied across dietary treatments, with group d (symbiotic supplementation) generally exhibiting superior teat morphology. Horizontal teat length was highest in group a (4.38±0.35) and lowest in group d (4.02±0.43). The rear teat distance from the floor was longest in group d (1.71±0.25) and shortest in group a (1.41±0.50), with a similar …

Trophic Niche Overlap Between Native And Alien Fish Species: A Challenge For The Aquatic Ecosystems, Rana Manzoor Ahmad, Abdul Majid Khan, Mariya Basharat, Muhammad Rizwan, Neelam Shahzadi, Muhammad Imran

Journal of Bioresource Management

The different physiological and biological challenges are introduced not only on land but also in aquatic ecosystems due to increasing climatic changes and human needs. One of these challenges is the introduction of invasive alien species to the native freshwater ichthyofauna. These species not only disturb the ecological balance of the native water bodies but can also be a vector for parasitic diseases. The current study is designed to disclose the trophic niche overlap among exotic (Cyprinus carpio and Oreochromis mozambicus) and indigenous fish species (Labeo calbasu and Cirrhinus mrigala) from Head Baloki (Ravi River), Punjab, …

Strongyloides Seropositivity Among Children Utilizing A Mobile Clinic, Lynda Aririguzo, Aditi Gupta, Norma Castillo, Cassandra Duran, Eva H Clark, Ankona Banerjee, Sanghamitra Misra

Faculty, Staff and Students Publications

Experts recommend screening for or presumptively treating strongyloidiasis in foreign-born immigrant children, though prevalence is unknown. Health care providers encounter barriers to following this recommendation. We aimed to describe Strongyloides seropositivity and risk factors among pediatric patients on a mobile clinic. Participants completed a written survey and provided blood for absolute eosinophil count (AEC) and Strongyloides IgG enzyme-linked immunosorbent assay (ELISA). From October 2022 to June 2023, 206 patients participated; 201 (97.6%) were born outside the United States; 97.1% (n = 200) were Hispanic. Most (68.9%) arrived less than 1 year before study enrollment. Four (1.9%) and 3 (1.5%) had …

Cyp1b1 Mediates Cigarette Smoke-Induced Lipid Accumulation In Alveolar Type 2 Cells, Yin Zhu, Siddhika Gamare, Francesca Polverino, Caroline A Owen, Payaningal R Somanath, Xiaoyun Wang, Duo Zhang

Faculty, Staff and Students Publications

Alterations in lipid profiles have been shown in patients with chronic obstructive pulmonary disease (COPD), but the underlying molecular mechanisms remain unclear. In this study, we aimed to investigate the role of cytochrome P450 family-1 subfamily B member 1 (CYP1B1) in cigarette smoke (CS)-induced lipid accumulation in alveolar type II epithelial (AT2) cells. We observed a steady increase in CYP1B1 protein levels in AT2 cells from COPD patients. Additionally, CS exposure induced CYP1B1 expression in AT2 cells of murine lungs. In vitro, treatment with cigarette smoke extract (CSE) not only upregulated CYP1B1 expression but also triggered lipid accumulation in AT2-like …

Observational Activation Of Anterior Cingulate Cortical Neurons Coordinates Hippocampal Replay In Social Learning, Xiang Mou, Daoyun Ji

Faculty, Staff and Students Publications

Social learning enables a subject to make decisions by observing the actions of another. How neural circuits acquire relevant information during observation to guide subsequent behavior is unknown. Utilizing an observational spatial working memory task, we show that neurons in the rat anterior cingulate cortex (ACC) associated with spatial trajectories during self-running in a maze are reactivated when observing another rat running the same maze. The observation-induced ACC activities are reduced in error trials and are correlated with activities of hippocampal place cells representing the same trajectories. The ACC activities during observation also predict subsequent hippocampal place cell activities during …

Engineered Exosomes With Krasg12d Specific Sirna In Pancreatic Cancer: A Phase I Study With Immunological Correlates, Valerie S Kalluri, Brandon G Smaglo, Krishnan K Mahadevan, Michelle L Kirtley, Kathleen M Mcandrews, Mayela Mendt, Sujuan Yang, Ana S Maldonado, Hikaru Sugimoto, Maria E Salvatierra, Luisa M Solis Soto, Cara Haymaker, Rick Finch, Mihai Gagea, Adam C Fluty, Steven J Ludtke, J Jack Lee, Abhinav K Jain, Gauri Varadhachary, Rachna T Shroff, Anirban Maitra, Elizabeth Shpall, Shubham Pant, Raghu Kalluri

Faculty, Staff and Students Publications

Oncogenic KRAS is amongst the key genetic drivers for initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC). Here, we show that engineered exosomes with KrasG12D specific siRNA (iExoKrasG12D) reveal a biodistribution in pancreas with negligible toxicity in preclinical studies in mice and Rhesus macaques. Clinical testing of iExoKrasG12D in the iEXPLORE (iExoKrasG12D in Pancreatic Cancer) Phase I study employed a non-randomized single-arm classical 3 + 3 dose escalation design (Phase Ia), followed by an accelerated titration design (Phase Ib) (NCT03608631). The primary outcomes included safety, tolerability and target engagement, and the secondary outcomes aimed to assess disease control. …

Collaborative Reflections On A Practical Journey Through Transcendental Phenomenology Data Analysis, Tyler Kulp, Hissah Alzahrani, Michele Parker

The Qualitative Report

Although transcendental phenomenology is widely recognized in qualitative research, there is limited discussion of how researchers come to understand and apply its methods in practice. This paper examines how reflective collaboration enhances the understanding and use of transcendental phenomenological analysis. It involves the first author, a recent doctoral graduate, the second author, a current doctoral student, and the third author, the doctoral advisor, using a collaborative approach. We draw upon the first author’s dissertation, providing clear, actionable guidance for simplifying the analysis process. The discussion highlights the value of collaborative reflection in making the methodology more accessible and enriching understanding …

Biodiversity Performance Of Living Wall Systems In Temperate Urban Environments: Plant Selection And Substrate Effects On Multi-Taxa Communities: Biodiversity Performance Of Living Wall Systems In Urban Environments, Paul Lunt, Thomas Murphy, James Buckley

School of Geography, Earth and Environmental Sciences

Urban densification threatens biodiversity, yet conventional greenspace expansion is con-strained by limited land availability. Living wall systems (LWS) offer potential biodiversity enhancement through vertical green infrastructure, though their ecological value re-mains underexplored. This study evaluated the biodiversity performance of three LWS in Plymouth, UK, using multi-taxa surveys to assess invertebrate communities, bird assemblages, and bat activity. A scoping review of 2,638 publications revealed limited research on LWS biodiversity, with only 27% of biodiversity-focused papers referencing specific species. Field surveys employed standardized protocols including flower-visiting pollinator observations, spider assessments, soil invertebrate extraction using Tullgren funnels, acoustic bird monitoring, and bat emergence …

Reworlding The Human: A Review Of Symbiotic Posthumanist Ecologies In Western Literature, Philosophy And Art, Asunción López-Varela Azcárate

Mabini Review

In recent decades, the interdisciplinary encounter between posthumanism and the environmental humanities has engendered rich intellectual terrain for rethinking the status of the human, the function of narrative, and the ethical imperatives of multispecies coexistence. The edited volume Symbiotic Posthumanist Ecologies in Western Literature, Philosophy and Art: Towards Theory and Practice (Peter Lang, 2023), curated by Peggy Karpouzou and Nikoleta Zampaki, contributes significantly to this dialogue. Organized in three thematic sections— “Framing the Symbiotic Posthumanist Ecologies,” “Symbiotic Posthumanist Ecologies in Literature and Art” and “Symbiotic Posthumanist Ecologies in Continental Philosophy”—the book weaves a cohesive tapestry that connects speculative fiction, ecological …

Rosas Sa Pampang, Bayan Sa Dagat: Eko-Salin Ng Mga Piling Tulang Arkipelahiko Ni José Martí Mula Sa Versos Libres (1913), Jose Monfred Sy

Mabini Review

This paper examines and translates five archipelagic poems by José Martí using the approaches of indirect translation and eco-translation. Through selected works from the collection Versos Libres (1913), Martí’s poetry is situated within the intercolonial relations between Cuba and the Philippines—two nations that underwent similar colonial experiences and share a strong tradition of anti-imperialist struggle. As a poet and revolutionary, Martí played a crucial role in Cuba’s liberation from the Spanish Empire. The selected and translated poems tulang “Midnight” (“Hatinggabi”), “Famous Island” (“Tanyag na Isla”), “Like Palm Trees Born in the Sand” (“Tulad ng mga Palmang Sumibol sa Buhangin”), “I …

The Poetry Of Rustica C. Carpio: A Mirror Of Humanistic Discourse, Truths And Values, Jan Raen Carlo Ledesma

Mabini Review

This paper is an attempt to analyze 8 poems in Filipino written by a prominent woman of Philippine letters, Rustica C. Carpio. Her disposition as a promising poet had never been the subject of local literary scholarship. As a poet, Carpio can be situated within the tradition of humanist poetry with her poems published in her book “Tilamsik ng Panitik” efficaciously chronicling the complex nature of man. The analysis situated the poems of Carpio within certain prominent traditions in Philippine poetry. In the form and content of her poetry, it is evident that we can see the strong influences of …

Traslación: From Mythos To Kairos, Johanne Randolf Andrada, Dominic Bautista Gonzales

Mabini Review

The pre-colonial Philippines was a vibrant archipelago filled with diverse faiths, ethnicities, and cultures, reflecting a rich blend of indigenous beliefs and practices. When Spanish colonization arrived, it dramatically transformed the religious landscape, introducing Christianity. Yet, remnants of pre-colonial spiritual traditions persisted, often merging with Catholic practices to create a distinct form of faith. This paper aims to explore the Traslación through various scholars. The focal point of this exploration is the Traslación, an annual event held every January 9 at Quiapo Church, which highlights the deep devotion many Filipinos have for the Black Nazarene. By drawing on both Western …

Automated Video Production Workflow Using Textual Source Documents, Kumar Dhanagopal

Defensive Publications Series

This disclosure describes a multi-stage workflow to facilitate automated video production from textual source documents. A system may process source documents to generate a narrative audio track. This audio can then be analyzed by a computing system to produce a corresponding visual storyboard, for example, by identifying concepts and scenes. Based on information from this storyboard, generative tools may be used to create multimedia assets, such as graphics and video clips. The generated audio and visual components may then be assembled into a video. This integrated method provides a process for converting text to video that can potentially reduce manual …

Neurolink-X: Restoring Brain–Body Communication Via An Implantable Neural Interface, George Karelias, George Karelias

Defensive Publications Series

Spinal cord injuries, stroke, and neurodegenerative diseases can disrupt motor pathways, causing severe loss of mobility and independence. NeuroLink-X proposes an implantable brain–body neural interface that restores connectivity by decoding cortical activity, bypassing damaged pathways, and delivering stimulation to muscles or spinal neurons. Unlike external prosthetics, NeuroLink-X is designed as a fully implantable, adaptive, closed-loop system that leverages AI-driven decoders and functional electrical stimulation to re-establish voluntary motor control. This article outlines the system’s architecture, methodology, and potential applications, supported by current advances in brain–computer interfaces and neuroprosthetics.

Vestigial Fiscal Constitutions, Joe Schomberg

St. John's Law Review

(Excerpt)

This Article examines the history and original intent of fiscal constitutions in the United States, providing helpful context for their usefulness today. It argues that, due to the rigidity of states’ fiscal constitutions, they are ultimately ineffective at preventing state and local governments from incurring more and more debt. Ultimately, it suggests that the weakness of state fiscal constitutions is a result of their functionality being overtaken by increased efficiencies in the capital markets and Tiebout-Tullock markets. Our state fiscal constitutions have suffered the same fate as our wisdom teeth or appendixes—they have become less useful and less relied …

Upland Switchgrass Cultivars Have Similar Bioethanol Production Profile Under Separate Hydrolysis And Fermentation: A Course Based Undergraduate Research Experience (Cure) In Biofuel Production, Kadyn Berg, Derek Follett, Adelyn Jackson, Mark Kalyegira, Jaleigha Kambeitz, Nathaniel Lanthier, Elaina Merfeld, Nathan Nelson, Sara Parliament, Peyton Plagman, Thomas Poegel, Alex Schemek, Sajan Mathew, Brady Steffen, Chloe Van Heuveln, Keerthi Mandyam, Arvid Boe, Ananda K. Nanjundaswamy

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

The modified Course-Based Undergraduate Research Experience (CURE) in bioenergy research evaluated four upland switchgrass cultivars namely Carthage, NE2010, RC Sundance, and Sunburst for bioethanol production using a separate hydrolysis and fermentation (SHF) process. The cultivars were not different in their biomass composition, sugar and ethanol yields. Carthage produced the highest ethanol yield (10 g/L), followed by Sunburst (9 g/L). A strong correlation was observed between glucose concentration at 48 hours (maximum glucose release) and ethanol yield at 72 hours. Ethanol production increased after 48 hours, and by 72 hours, residual glucose levels in the fermentation medium were negligible. The fermentation …

The Algorithmic Public Sphere: Ai-Generated News Site As A Conduit To Social Capital, Seungahn Nah, Xinlei Wu, Ernest Makata, Jun Luo, Ian Koratsky, David Park, Seungbae Kim

Human-Machine Communication

A growing body of scholarship on AI-generated news has examined its impact on various outcomes. However, less attention has been paid to the actual implementation of AI-generated news sites and their effectiveness on civic consequences. This study examines the effects of an AI-generated, community-centered, nonprofit news site on civic outcomes such as trust in nonprofit organizations, trust in AI-generated news, social capital, and civic engagement. Data was collected from participants at a large southeastern university who visited the AI-generated news site over a four-week period and responded to a series of open-ended questions weekly. A total of 721 open-ended responses …

Paws And Effect: Canine Companionship And Outcomes In The Chronic Health Condition Hypermobile Ehlers-Danlos Syndrome, Kimberley C. Schenke, Joanna Foster, Danielle Stephens-Lewis

People and Animals: The International Journal of Research and Practice

Emerging research suggests canine companions may support the management of health conditions, yet evidence within complex, long-term conditions like hypermobile Ehlers-Danlos Syndrome (hEDS) remains limited. hEDS is a multifaceted condition often associated with social withdrawal. Thus, the current research provided a high-powered investigation into whether the nonjudgmental support of canine companions could improve health and well-being outcomes for individuals with hEDS. An online survey of 401 participants was utilized to compare differences in health and well-being among individuals with hEDS who have a canine companion to those who do not. Results revealed that participants with canine companions experienced fewer difficulties …

Investigating Processes For Pattern Creation Using Coupled Bulk-Surface Pdes When Linear Reactions Occur, Muflih Alhazmi

University of Bisha Journal for Basic and Applied Sciences

In this paper, the reaction-diffusion partial differential equations governing the coupled bulk surface in the presence of linear reactions are investigated. Suitable boundary conditions of linear Robin-type are imposed for the aforementioned system in both the bulk and on the surface on stationary volumes. The current situation is simulated using four PDE’s, namely, two equations for the bulk, and other two different equations are introduced for the surface bounding. The analyses methodology is depending on converting the system into dimensionless forms then rigorous linear stability analysis is performed to determine the necessary and sufficient conditions for pattern formation. Various cases …

Program Evaluation: Best Practices And Examples For Nonprofits, Erica Bassett, Faith M. Manchester

Journal of Nonprofit Innovation

No abstract provided.

Realities Of Mexican Civil Society Organizations: Index For The Promotion Of Activities Of Civil Society Organizations, Pablo Armando Gonzalez Ulloa Aguirre

Journal of Nonprofit Innovation

This article presents the findings derived from the construction of an Index that evaluates the state of promotion of Civil Society Organizations (CSOs) across Mexico’s 32 federal entities during the year 2021. It also outlines the criteria considered in building the Index and the results obtained in each of its dimensions. The Index provides a comprehensive and multidimensional perspective on the study of CSO promotion, analyzing legal, institutional, and programmatic dimensions with the aim of comparing progress and setbacks in this area. In doing so, it offers an opportunity to improve certain aspects as more data is generated and made …

Property Rights In The Face Of Historic Injustice, Bas Van Der Vossen, Fabian Wendt

Philosophy Faculty Articles and Research

It seems natural to adopt a historical approach when it comes to property titles: When property titles have a clean history, they are to be respected as a matter of justice; when they do not have a clean history, for example, in cases of prior theft, they must be returned to the original owners or their descendants. But the historical approach has serious drawbacks. This paper presents an alternative. Starting from the idea that property rights must be stable, we offer an account of why historic injustices sometimes do, but sometimes do not, undermine current titles. This account offers a …

Addressing The Abuse Of Monopsony Power In Labor Markets: Examining Potential Public And Civil Law Remedies And Sanctions, Zofia M. Mazur

Yearbook of Antitrust and Regulatory Studies

Although thousands of reported cases involve allegations of firms illegally forming cartels in product markets, relatively few deal with similar allegations in labor markets. Moreover, as observed in legal doctrine, labor markets tend to be more concentrated than product markets and, consequently, more susceptible to anticompetitive conducts by undertakings. The article, therefore, analyzes the so-called monopsony power in the labor market, which refers to any case where employers hold labor market power that allows them to unilaterally determine wages or to worsen working conditions by reducing employment.

It is argued that competition law should be used to effectively curb abuse …

Western Australian And South Australian Grain Enterprise Emission Intensities And Gross Margins: A Review, Christophe D'Abbadie, Ross Kingwell

Farm Systems and Economics research articles

Drawing on various datasets, crop enterprise emission intensities and gross margins are reported for the main broadacre crops grown in Western Australia and South Australia. Values are reported for various rainfall regions and across time, and for different farm performance groupings. As a generalisation, in each region, wheat and canola production display marked increases in emissions intensity across the study period whilst legume crops’ emission intensities increase far less. Wheat crops display upward emission intensity trajectories across time whilst displaying different rates of increase in emissions intensity according to regional rainfall. Canola demonstrates higher emissions intensities per tonne compared to …

Psychiatric Associations With Barriers To Use Of Mental Health Services In Medical Students, E. Cadence Rarity, Nora Newcomb, Aishwarya Vuppala, Jade Brunicardi, Kim Van, Amelia C. Phillips

Journal of Wellness

Introduction: Medical students experience stress, anxiety, and depression at rates greater than those of the general population. Medical students also underutilize mental health services. There exists a need for a comprehensive, multivariate analysis of the reasons medical students do not pursue mental health services, and the undesirable mental health outcomes that are associated with these barriers. This study associates psychiatric phenomena of stress, anxiety, and depression within the context of barriers to use of mental health services in medical students.

Methods: In this cross-sectional study, medical students (N = 128) from the University of South Florida engaged with …