Digital Commons Network^™

Effects Of The Kcnq (Kv7) Channel Opener Ezogabine On Resting-State Functional Connectivity Of Striatal Brain Reward Regions, Depression, And Anhedonia In Major Depressive Disorder: Results From A Randomized Controlled Trial, Avijit Chowdhury, Sarah Boukezzi, Sara Costi, Sara Hameed, Yael Jacob, Ramiro Salas, Dan V Iosifescu, Ming-Hu Han, Alan Swann, Sanjay J Mathew, Laurel Morris, James W Murrough

Faculty, Staff and Students Publications

Background: Major depressive disorder (MDD) is a leading cause of disability worldwide, with available treatments often showing limited efficacy. Recent research suggests that targeting specific subtypes of depression and understanding the underlying brain mechanisms can improve treatment outcomes. This study investigates the potential of the potassium KCNQ (Kv7) channel opener ezogabine to modulate the resting-state functional connectivity (RSFC) of the brain's reward circuitry and alleviate depressive symptoms, including anhedonia, a core feature of MDD.

Methods: A double-blind, randomized, placebo-controlled clinical trial in individuals with MDD ages 18 to 65 years compared daily dosing with ezogabine (n= 19) with placebo (n …

Discovering An Effective Disciple-Making Method For Men, Clifton J. Hefley

Doctor of Ministry (DMin)

This dissertation explores the development of an effective disciple-making method for men by integrating insights from early church discipleship practices and modern missional strategies such as Disciple Making Movements (DMM) and Church Planting Movements (CPM). Rooted in biblical theology and the teachings of the Patristic Fathers, the study evaluates how obediencebased, relational discipleship shaped early Christianity and compares it with contemporary missional frameworks promoted by leaders like David Garrison, Alan Hirsch, and Steve Addison. Against the backdrop of a sharp decline in church attendance and male engagement in Western Christianity, this research identifies the need for a reproducible, movement-oriented model …

'In A Mirror, Dimly, Then Face To Face:' Reflecting On Bodily Sin And Spiritual Purity In The Central Female Figures Of Hugo Van Der Goes' Vienna Diptych, Sara Kluka

Theses

This thesis seeks to examine the so-called Vienna Diptych (1478/1479) by Hugo van der Goes. The two panels of the diptych have been displayed together since the 19th century, yet difficulties in provenance and the dating of the artist’s oeuvre have resulted in the continued questioning of its intended creation as a single campaign. This research seeks to assert the diptych’s thematic unity through a concentrated analysis of its leading female figures, a vantage point that has not yet been fully addressed in the literature. This paper will therefore examine the iconographic precedents for the unique imagery of the panels …

Ambiguous Bodies: Third Gender Expressions In Ancient Maya Art, Jayme Horne

Theses

This thesis examines the interpretations of Lintels 23, 24, and 25 from Yachilán, Drawing 18 from Naj Tunich, and Stela H from Copán, with a specific focus on third gender expression. These artworks depict figures that blend masculine and feminine attributes, from costuming to actions, to present intentionally ambiguous representations of the body that all ancient Maya people would have understood. Third gender expression is defined through the blending of masculine and feminine signifiers. It is a gender identity for people who do not identify as male or female, but rather as neither, both, or a combination of male and …

Immersive Art, Nature, And Afrofuturism: Cultivating Wellness And Cultural Awareness, Jojo Abenaavi Wright

Theses

This research demonstrates how Afrofuturistic art, combined with nature and scent, enables powerful methods to transform African Diaspora perceptions and support holistic wellness through sensory-emotional engagement. The project introduces The Next Narrative: An Immersive Journey Through Black Time as a multisensory immersive exhibition that combines Afrofuturistic aesthetics with Harlem Renaissance cultural elements. The exhibition presents salons as a sequence that allows visitors to experience time through visual, sonic, and atmospheric transitions. The three senses of touch, scent, and sound operate as fundamental tools for grounding and transformation, which disable analytical thinking while using bodily experiences to perform decolonial memory work. …

The Mystical Kitchen: Feminist Magic And Alchemical Transformation In The Work Of Lenora Carrington, Theresa Burwell

Theses

This thesis analyzes the inherent feminism in alchemical and magical symbolism, particularly in representations of kitchens in the art and writing of Leonora Carrington. The kitchen has historically been viewed as a gendered space for domestic work. By subverting cultural and religious conventions, Carrington’s kitchen becomes a site for transmutation and feminine ritual. Using feminist discourse, formal art historical analysis, and the history of alchemical symbolism, this thesis asserts that Carrington’s imagery transforms the kitchen from an oppressive domestic space to a mystical laboratory of feminine power. A thorough analysis of Grandmother Moorhead’s Aromatic Kitchen (1975) and The House Opposite …

Protein Kinase Rock1 Activates Mitochondrial Fission Linking To Oxidative Stress And Muscle Atrophy, Meijun Si, Jihong Chen, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard R Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu

Faculty, Staff and Students Publications

Introduction: Chronic kidney disease (CKD) is associated with protein-energy wasting, characterized by a reduction in muscle mass and strength. Although mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of muscle wasting, underlying mechanisms remain unclear.

Methods: Here, we used transcriptomic analysis, metabolomics analyses, and mouse gene manipulation to investigate the effects of mitochondrial plasticity and oxidative stress on muscle wasting the subtotal nephrectomy mouse models of CKD. The mice with CKD were age- and sex-matched to sham-operated controls.

Results: Through these approaches, Rho-associated kinase ROCK1 emerged as a key molecule responsible for the observed mitochondrial fission and oxidative …

Analyzing Sea Level Rise Scenarios Impact On The Mobility, Infrastructures, Environment Of Abu Dhabi And Defining Solutions By Creating A Digital Twin Using Gis And Game Engine, Justine Sylviane Lucie Sarrau

Dissertations

This dissertation investigates the potential impact of future sea level rise (SLR) scenarios on the city of Abu Dhabi. With climate change, many coastal towns are at risk of experiencing this type of natural hazard. Currently, no precise scenario simulations have been developed, mainly due to the use of low spatial resolution elevation data. Additionally, the difficulty in understanding the real impacts persists when analyses rely solely on traditional cartography and GIS methods. This dissertation aims to advance the field by offering a new approach, which involves creating a comprehensive dynamic 3D simulation with dynamic flowing water. This model, defined …

Fructose And Glucose From Sugary Drinks Enhance Colorectal Cancer Metastasis Via Sord, Tianshi Feng, Qin Luo, Yanlin Liu, Zeyu Jin, David Skwarchuk, Rumi Lee, Miso Nam, John M Asara, Daya R Adye, Philip L Lorenzi, Lin Tan, Guangsheng Pei, Zhongming Zhao, Neda Zarrin-Khameh, Adriana Paulucci-Holthauzen, Brian W Simons, Ju-Seog Lee, Scott Kopetz, Jihye Yun

Faculty, Staff and Students Publications

The consumption of sugar-sweetened beverages (SSBs), which contain high levels of fructose and glucose, has been causally and mechanistically linked to an increased risk of colorectal cancer (CRC). However, the effects of SSB consumption on advanced stages of disease progression, including metastasis, remain poorly understood. Here we show that exposure of CRC cells to a glucose and fructose formulation-reflecting the composition of both high-fructose corn syrup and sucrose found in SSBs-enhances cellular motility and metastatic potential compared to glucose alone. Given that CRC cells grow poorly in fructose alone, and cells in vivo are not physiologically exposed to fructose without …

Effective Enforcement Of Laws Prohibiting Underage Tobacco Product Sale Is Needed, Harold J Farber

Faculty, Staff and Students Publications

No abstract provided.

Analyzing The Learning Curve Of Vnotes Sacrocolpopexy By The Cumulative Summation Test: A Cohort Study, Wenyu Liu, Nannan Sun, Yuejiao Zhang, Yuyan Li, Weihao Lai, Youjun Zhou, Xiaoming Guan, Juan Liu

Faculty, Staff and Students Publications

Background: The learning curve of transvaginal natural orifice transluminal endoscopic sacrocolpopexy (vNOTES-SC) in the treat of pelvic organ prolapse (POP) is critical yet underexplored. Our objective is to describe the learning curve and surgical complications of vNOTES-SC, taking into account the factors that affect operative time and evaluate the long-term follow-up outcomes of this surgery.

Methods: We conducted a hospital-based cohort study involving patients who underwent vNOTES-SC from June 2017 to May 2024. All surgeries were performed by a single surgeon with over 20 years of surgical experience. This study employed cumulative summation test (CUSUM) analysis to quantify the learning …

The Bridwell Quarterly Issue 29 Fall 2025, Anthony Elia, Michelle S. Ried

Bridwell Library Publications

No abstract provided.

Wildfire Emergency Response And Evacuation Framework Using Drones: Phase I, Hovannes Kulhandjian

Mineta Transportation Institute

Wildfires are escalating in frequency and severity due to climate change, posing increasing threats to human life, infrastructure,and ecosystems. Traditional wildfire management systems struggle to respond effectively to rapidly evolving fire conditions. This research presents a novel, AI-powered Wildfire Emergency Response and Evacuation Framework that integrates autonomous unmanned aerial vehicles (UAVs, AKA “drones”), multi-sensor data fusion, and machine learning (ML) for real-time fire detection, evacuation planning, and search and rescue (SAR) operations. Central to the system is the Dynamic Wildfire Response Algorithm (DWRA), a hybrid decision-making framework combining AI-driven techniques including reinforcement learning (RL), genetic algorithms (GA), and deep learning …

Dignity And Deepfakes, Michael Goodyear

Articles & Chapters

Today, we face a dangerous technosocial combination: AI-generated deepfakes and the Internet. Believable and accessible, these deepfakes have already spread sex, lies, and false advertisements across the Internet and targeted everyone from Taylor Swift to middle school students. Dissemination of deepfakes inflicts multifarious dignitary harms against their victims—especially women and LGBTQ+ persons—stripping them of control over their own identities, harming their reputations, and ostracizing them from society through shame.

Yet this is not the first time a new technology for capturing one’s likeness and a method for disseminating images threatened individuals’ dignity. In the late nineteenth century, the right of …

The Adventures Of Pip! The Culex Pipiens: An Educational Mosquito Comic Book For Kids, Victoria Garziano

Department of Entomology: Distance Master of Science Projects

“The Adventures of Pip! The Culex pipiens” is an educational comic book series designed to engage a younger audience (4th grade – 5th grade) while introducing them to key topics related to mosquitoes. Although mosquitoes are often viewed solely as a nuisance, they are also fascinating creatures. A better understanding of their life cycle and behavior can improve our ability to manage them effectively. Early education on these topics can raise long-term awareness and behaviors that continue into adulthood. This comic book series offers an accessible and enjoyable format for a science lesson and can be effectively integrated into a …

Proteomic Approaches To Investigate Pp2a-B55 Substrates And Cellular Function, Brennan C. Mcewan

Dartmouth College Ph.D Dissertations

Cell division is controlled in large part by reversible protein phosphorylation. The phosphorylation state of proteins during mitosis and other phases of the cell cycle represents a careful balance of activity between kinases and opposing phosphatases. The phosphoprotein phosphatase (PPP) family is responsible for the majority of serine and threonine dephosphorylation. Members of the PPP family are composed of a catalytic subunit paired with a regulatory subunit that targets them towards specific substrates.

The most abundant PPP, PPP2A, paired with its regulatory B55 subunit, is thought to be the phosphatase responsible for the dephosphorylation of substrates during mitotic exit. Despite …

Robust Hashing For Improved Cnn Performance In Image-Based Malware Detection, Sanket Shekhar Kulkarni, Fabio Di Troia

Faculty Research, Scholarly, and Creative Activity

This paper presents a comparative study on the impact of robust hashing in enhancing image-based malware classification. While Convolutional Neural Networks (CNNs) have shown promise when working with image-based malware samples, their performance degrades significantly when obfuscation techniques are taken into consideration to hamper the malware classification or detection. To address this, we apply a robust hashing technique that generates invariant visual representations of malware samples, enabling improved generalization under obfuscation implemented as image salting. Using a custom obfuscation method to simulate polymorphic variants, we evaluate MobileNet, ResNet, and DenseNet architectures across five salting conditions (0% to 40%). The results …

Safe Sex In The Age Of Big Tech Feminism, Brenda Dvoskin, Thomas E. Kadri

Articles

Lawmakers and technology companies are regulating online sexuality in the name of feminism. Whereas libertarian ideals dominated early debates about internet governance, "safety" has become the rallying cry to regulate online activity in the age of Big Tech. Legislators across the political spectrum and companies around the world are devising interventions meant to keep people - and especially women safe from the risks of online sexuality. Through law and technology, they target everything from privacy invasions to unwanted messages to sexual deepfakes. We call this regulatory and ideological trend Big Tech feminism.

This Article interrogates the feminist strands animating Big …

Beyond Democracy: How A Free Press Supports The Rule Of Law, Erin C. Carroll

Cardozo Law Review

Widespread agreement has existed for centuries that a free press is essential to democracy. But legal scholars have spent almost no effort thinking about why else we might need a free press. This article attempts to widen the aperture. It argues that as the free press is essential to democracy, it is just as essential to a separate value: the rule of law. Recognizing and investigating the connections between the free press and the rule of law is essential right now. It can help us discern how the press can create friction against the erosion of both rule of law …

Beyond Democracy: How A Free Press Supports The Rule Of Law, Erin C. Carroll

Georgetown Law Faculty Publications and Other Works

Widespread agreement has existed for centuries that a free press is essential to democracy. But legal scholars have spent almost no effort thinking about why else we might need a free press. This article attempts to widen the aperture. It argues that as the free press is essential to democracy, it is just as essential to a separate value: the rule of law.

Recognizing and investigating the connections between the free press and the rule of law is essential right now. It can help us discern how the press can create friction against the erosion of both rule of law …

Young Feminist Organizing In The State Of Yucatán, Mexico: A Case Study, Natalia Tenorio, Sonia Cruz, Esperanza Basurto, Anel Bobadilla, Paulina Márquez, Ricardo Regules

Adolescents and Young People

As part of the Participatory Action Research (PAR) Study on Young Feminist Organizing in Mexico and Kenya, this case study was conducted in the Yucatán, Mexico to understand the particularities of the feminist movement and organization led by young women in this state. The case study included in-depth interviews and focus groups with representatives of feminist organizations and collectives, civil society organizations, and public institutions. These were conducted in Mérida, the capital of the state of Yucatán, as described in the methodological note.

This brief summarizes the current issues that mobilize young feminists in the state of Yucatán, their forms …

Jóvenes Feministas En Yucatán: Estudio De Caso, Natalia Tenorio, Sonia Cruz, Esperanza Basurto, Anel Bobadilla, Paulina Márquez, Ricardo Regules

Adolescents and Young People

En el marco del Proyecto de Investigación Acción Participativa de Juventudes Feministas en México y Kenia, llevamos a cabo un estudio de caso en el Estado de Yucatán. El objetivo ha sido entender las particularidades que la organización de las jóvenes tiene en este Estado.

Para ello, llevamos a cabo entrevistas a profundidad y reuniones con organizaciones feministas, instituciones públicas y organizaciones de la sociedad civil trabajando en Mérida, tal y como se recoge en la nota final metodológica. Las citas textuales que aparecen a continuación son todas de distintas participantes de los grupos focales realizados de manera presencial y …

Chapter 3: The Freezing Spell, Garon C. Smith

G. Wiz’s Book of Spells

The Freezing Spell is a fun one to pass off as a wizarding feat. A supersaturated solution of sodium acetate trihydrate is nucleated with seed crystals that the demonstrator has cleverly hidden on the tip of his/her middle finger. When the fingers are snapped over the open throat of the flask that holds the solution, a snowy hemisphere of crystallization grows over the next 10 seconds. The flask can then be inverted to show that it is now solid. The flask has also gone from room temperature to a nice handwarmer temperature of about 120^oF due to the …

Adapting To Inflationary Pressures: Household Coping Strategies In Urban Egypt (2016– 2025), Mohamed Mohamed Ashraf Kamal

Theses and Dissertations

Over the past decade, Egypt has faced persistent economic challenges including repeated currency devaluations, high inflation rates, subsidy reforms such as the gradual reduction of food and energy subsidies, and the ripple effects of global crises that have significantly impacted household well-being, especially in urban areas. These pressures have eroded purchasing power and heightened food insecurity, especially among low- and middle-income families. Although substantial attention has been paid to macroeconomic indicators, there remains a critical gap in understanding how households adapt on a daily basis to manage financial stress and sustain their livelihoods. This inquiry is especially timely, as household …

Life In The Kingdom: Reimagining Theological Education For A Post-Secular Global Age, Jose Philip

Great Commission Research Journal

Theological education faces a profound crisis, shaped by globalization, secularization, and an epistemological fracture that prioritizes intellectual mastery over spiritual formation. Many seminaries fail to cultivate graduates who are spiritually grounded and missionally engaged due to models rooted in Enlightenment rationalism and managerial pragmatism. This paper advocates for reimagining theological education as a Kingdom-centered vocation, emphasizing transformative participation in the life of God. The paper calls for a shift from content delivery to character formation, centering theological education on faithful, embodied witness to God's mission in a complex world.

Viewsrd: 3d Visual Grounding Via Structured Multi-View Decomposition, Ronggang Huang, Haoxin Yang, Yan Cai, Xuemiao Xu, Huaidong Zhang, Shengfeng He

Research Collection School Of Computing and Information Systems

3Dvisual grounding aims to identify and localize objects in a 3Dspacebasedontextualdescriptions. However, existing methods struggle with disentangling targets from anchors in complex multi-anchor queries and resolving inconsisten cies in spatial descriptions caused by perspective variations. To tackle these challenges, we propose ViewSRD, a frame work that formulates 3D visual grounding as a structured multi-view decomposition process. First, the Simple Rela tion Decoupling (SRD) module restructures complex multi anchor queries into a set of targeted single-anchor state ments, generating a structured set of perspective-aware de scriptions that clarify positional relationships. These de composed representations serve as the foundation for the Multi-view …

Fatal Cases Of Poisoning Diagnosed In Medicolegal Directorate Of Baghdad, Ahmed Ghadhban, Nabeel Hashim

Iraqi Postgraduate Medical Journal

Abstract: Background: Poisoning is a significant contributor to morbidity and mortality throughout the world. Providing accurate statistical data is essential to understand the different aspects of poisoning cases for the seek of diagnosis particularly at the medicolegal side, and also for the seek of better management. Objective: To investigate the epidemiological characteristics, and the postmortem findings of fatal poisoning cases referred to the medicolegal directorate of Baghdad. To identify the most common toxic agents, and the manner of death, in addition to demonstrate the demographic factors for the purpose of prevention and management.Materials and Methods: Retrospective study analyzing autopsy records …

Multilateral Organizations And Health Emergency Management During Crisis: The Case Study Of The World Health Organization During Covid-19 Pandemic, Aya Helmy Hamada

Theses and Dissertations

Multilateral organizations, such as the World Health Organization (WHO), play a key role in managing health emergencies during crises. During the COVID-19 pandemic, WHO achieved significant progress by supporting countries with technical assistance, guidelines, and essential resources. As well as providing technical guidance, sharing information, and coordinating among member states. This experience highlighted the importance of WHO in tackling global public health problems and showed how multilateral collaboration can help address complex challenges. Moreover, risk and crisis communication proved to be a critical part of WHO’s response, ensuring that clear and timely information reached the public and stakeholders. Despite these …

Emoshortcuts: Emotionally Expressive Body Augmentation For Social Mixed Reality Avatars, Hyuna Seo, Youngki Lee, Rajesh Krishna Balan, Thivya Kandappu

Research Collection School Of Computing and Information Systems

We present EmoShortcuts1, a novel social Mixed Reality (MR) framework that enhances emotional expression by dynamically augmenting avatar body gestures to reflect users’ emotional states. While social MR enables immersive remote interactions through avatars, conveying emotions remains challenging due to limitations in head-mounted display (HMD) tracking (e.g., missing lower-body movements, such as stomping or defensive postures), and users’ tendency to deprioritize nonverbal expressions during multitasking. EmoShortcuts addresses these challenges by introducing an augmentation framework that generates expressive body gestures even when users’ physical movements are restricted. We conducted a formative study with 12 participants to identify key challenges in emotional …

Art4math: Handwritten Mathematical Expression Recognition Via Multimodal Sketch Grounding, Yang Zhou, Jin Wang, Yuxiao Zhang, Kaixiang Huang, Guodong Lu, Jingru Yang, Shengfeng He

Research Collection School Of Computing and Information Systems

Handwritten Mathematical Expression Recognition (HMER) remains a challenging task due to the structural complexity of mathematical notation and the ambiguity of handwritten symbols-e.g., ''ρ'' vs. ''p'' or ''B'' vs. ''β''. While stroke-based models offer disambiguation via temporal cues, most existing methods are constrained by coarse modality fusion and a lack of fine-grained cross-modal alignment, further hindered by limited annotated data. We introduce Art for Math (Art4Math), a novel framework that leverages the structural richness of human sketches to enhance HMER through fine-grained, modality-aware learning. Art4Math follows a two-stage training paradigm: Art Grounding (A-Grd) and Math Decoding (M-Dec). In A-Grd, the …