Digital Commons Network^™

Unveiling The Anticancer Potential Of Syzygium Cumini: In Silico Insights Into Its Mechanistic Action Against Non-Small Cell Lung Cancer, Nur Sofiatul Aini, Win Darmanto

Karbala International Journal of Modern Science

Non-small cell lung carcinoma (NSCLC) is the most periodic type of lung cancer and the second most diagnosed cancer globally. Syzygium cumini is plant that extensively used in cuisine and traditional medicine. However, its potential for NSCLC treatment has not yet been elucidated. This study determined the potential of S. cumini as anti-NSCLC using in silico approaches. The in silico study was applied to perform active compound analysis, selection of target candidates, network pharmacology, functional annotation, molecular docking, and molecular dynamics simulation, respectively. Based on open source databases, S. cumini contained 115 compounds and 14 of them predicted to have …

We Built This: Redesigning Higher Education From The Ground Up While They Try To Burn It Down, Shawntay King, Juanita E. Marquez, Keisha Rembert, Jolene Taylor, Thera Tilmon

SPACE: Student Perspectives About Civic Engagement

Our text, We Built This: Redesigning Higher Education from the Ground Up While They Try to Burn It Down, examines how recent federal policy shifts, particularly the 2025 Dear Colleague letter and the Project 2025 educational platform, function as deliberate acts of deconstruction. These measures threaten to dismantle equity infrastructures in higher education while intensifying the erasure of Black women’s labor, leadership and legacy in the academy. Through Critical Policy Analysis and Black feminist thought, we argue that these policies operate simultaneously as blueprint and wrecking ball, systematically unraveling decades of progress and constraining the very communities that have sustained …

The Other Side Of Rousseau’S Political Theology: The Influence Of Plutarch And Calvin On The Profession Of Faith Of The Savoyard Vicar, Thomas Daniel Moore

Yale Divinity School Theses

This thesis examines Jean-Jacques Rousseau’s Profession of Faith of the Savoyard Vicar, paying particular attention philosophic influences of the Vicar, especially as pertains to metaphysics. It fills a void in the scholarship, as there is not much work in general–and especially in recent years–on the relationship between Plutarch, Calvin, and Rousseau. Indeed, although Rousseau’s love for Plutarch is often acknowledged, it is seldom explored; and, when it is explored, it is typically only with an eye to the political realm, and never the metaphysical dimension. Calvin, when mentioned in association with Rousseau at all, is typically interpreted as a minor …

From Dictionary To Classroom: Philippine English In The Oxford English Dictionary And Language Education In The Philippines, Danica Salazar

Journal of English and Applied Linguistics

The present article offers an overview of the Oxford English Dictionary’s (OED) continuing efforts to improve its coverage of words originating from world varieties of English, such as those spoken in Anglophone communities in postcolonial Southeast Asia. In these new centers of English, millions of second-language speakers use a variety of linguistic mechanisms to adapt the English word store to their unique cultural and social milieu, and the OED is documenting this distinctive vocabulary by including a wider range of lexical innovations from Southeast Asian varieties of English that more accurately reflect the way that the language is being used …

Optimization Of Actuator Stiffness And Actuation Timing Of A Passive Ankle Exoskeleton: A Case Study Using A Musculoskeletal Modeling Approach, Jania Williams, Cody P. Anderson, Arash Mohammadzadeh Gonabad, Farahnaz Fallahtafti, Sara A. Myers, Hafizur Rahman

School of Podiatric Medicine Publications

Objective: A modeling and simulation tool, OpenSim, was used to determine the optimal relationship between actuator stiffness and actuation timing of a passive ankle exoskeleton for reducing metabolic costs during walking. We hypothesized that the absolute minimum in total metabolic cost would exist at an actuation timing of 15% of stance and at a spring stiffness of 7.5 kN/m. We also hypothesized that a local minimum in total metabolic cost would exist at an actuation timing of 50% of stance. Methods: Bilateral kinematics and kinetics data were collected on a healthy male walking overground wearing his regular tennis shoe. The …

Implementation Of Neutrosophic Logic For Food Security And Agricultural Productivity Analysis In South Asian Countries, Muhammad Yaseen, Korntima Phattanasin, Jamil Afzal, Muhammad Afzal

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Hyperprobabilistic Modeling Of Learning Outcomes In College Blended Physical Education Teaching Process, Yanmin Li, Shiqiang Dou

Neutrosophic Sets and Systems

No abstract provided.

Prosecuting Nihilistic Violent Extremism: An Examination Of Federal And State Charges Against 764 And Related Networks, National Counterterrorism Innovation, Technology, And Education Center

Reports, Projects, and Research

In April 2025, U.S. authorities arrested two alleged leaders of 764, a 21-year-old U.S. citizen residing in Greece and a 20-year-old U.S. citizen from North Carolina. They were arrested on charges of operating an international child-exploitation enterprise, in connection with the online terrorist network ‘764’. US Attorney General Pamela Bondi described the group as “one of the most heinous online child exploitation enterprises we have ever encountered – a network built on terror, abuse, and the deliberate targeting of children”. The arrests marked a significant development in federal efforts to disrupt and dismantle the network, while simultaneously underscoring the scale …

Can’T Blaine A State For Trying: Writing A Constitutional Blaine Amendment After Carson V. Makin, Ry Stratton

Villanova Law Review (1956 - )

No abstract provided.

Development Of A Procedure For Prion Surveillance In The Laboratory Setting, Damian Gorski, Isaac Schauer, Kane Spicker, Ananya Tupaki-Sreepurna, Fei Wang, Claudio Soto, Sandra Pritzkow

Faculty, Staff and Student Publications

Infectious prions readily adhere to common surfaces, retain infectivity, and are highly resistant to conventional decontamination, posing significant biosafety challenges in the medical and research environments. Recent occupational exposures underscore the urgency of improving safety measures. Here, we describe an approach combining foam-swab surface sampling and protein misfolding cyclic amplification to enhance prion surveillance. Our results demonstrate the ability to detect prions most relevant to human health directly from contaminated surfaces, even at 100 million-fold dilutions of the brain. We applied our method to assess the completeness of prion decontamination and show that high prion quantities can resist even approved …

Updating The Epidemiology Of Blastomycosis And Histoplasmosis In The United States, Using National Electronic Health Record Data, 2013-2023., Juliana G E Bartels, Simon K. Camponuri, Theo T. Snow, Brittany L Morgan Bustamante, Natalie J. Kane, Rose Reynolds, Aidan Lee, Mark A. Hoffman, Theodore C. White, Justin V. Remais, Jennifer R. Head

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Where surveillance data are limited, nationally representative electronic health records allow for geographic, temporal, and demographic characterization of the fungal diseases blastomycosis and histoplasmosis.

METHODS: We identified incident blastomycosis and histoplasmosis cases from 2013 to 2023 within Oracle EHR Real-World Data, which comprises 1.6 billion healthcare encounters nationally. To characterize spatiotemporal incidence trends, we used generalized estimating equations weighted for nonrepresentativeness of electronic health record-reporting facilities. We computed standardized incidence rate ratios (sIRRs), which relay relative differences in standardized incidence rates between regions, race/ethnicity, gender, and age subgroups and the national population.

RESULTS: National incidence rates in 2023 were …

Student-Centered Approaches For Improving Teaching Quality In College Animation Courses Under Possibility Neutrosophic Soft Sets, Xiao'ou Ji, Juan Song

Neutrosophic Sets and Systems

No abstract provided.

Animation And Game Design Effectiveness Analysis For Skill Development: An Analytical Framework Using Neutrosophic Hesitant Fuzzy Set, Na Ji, Xiao'ou Ji

Neutrosophic Sets and Systems

No abstract provided.

Crediting Prison Crime, Jacob Gordon

NULR Online

No abstract provided.

Differential Impacts Of Wind And Waves On Albatross Flight Performance In Two Ocean Basins, Ian J. Maywar, Richard A. Phillips, Rachael A. Orben, Melinda G. Conners, Scott A. Shaffer, Lesley H. Thorne

Faculty Research, Scholarly, and Creative Activity

Background: Albatrosses can commute long distances to feed during the breeding season by avoiding energetically costly flapping flight. Energy from both wind and waves can be used to sustain soaring and reduce flapping flight, yet most studies of albatross flight have focused solely on the influence of wind. Methods: To examine how wind and waves allow albatrosses to reduce energetic costs by limiting flapping flight, we analyzed how the flap rates of five albatross species (370 individuals) across two ocean basins varied with wind speed and swell height. Results: For all study species, soaring using both wind and waves resulted …

A Modular Design And Construction Framework For Enhancing The Sustainability Of National Housing Projects In Egypt, Ayman Ahmed Ezzat, Farah Ibrahim El Sahzly

Mansoura Engineering Journal

Egypt’s national housing sector faces mounting sustainability challenges due to outdated design and construction practices that cause material waste, high costs, and inefficient resource use. This study develops a framework for integrating modular design and construction principles into Egypt’s National Housing Projects (NHPs) to strengthen their social, economic, and environmental sustainability. A mixed-method approach combined a literature review, case studies, and a survey of Egyptian Architectural Design Firms (ADFs). The literature review revealed a global consensus on the benefits of modular design and construction, such as improved efficiency, reduced waste, and faster project delivery, yet found limited adoption in Egypt …

Dialogic Engagement In Scientific Discourse: An Appraisal Analysis Of Discussion Sections By Arab L2 And Native English Writers, Mohammed Ahmed Mohammed Alzahrani

UB Journal for Humanities

The discussion section of a research article is a critical site of persuasion, where writers must strategically negotiate claims, credibility, and collegiality. This study investigates how cultural and linguistic backgrounds shape this delicate rhetorical act by conducting a contrastive analysis of dialogic engagement in scientific discussions. Employing Martin and White’s (2005) Appraisal Theory, specifically the Engagement Framework, the researcher analyzed a specialized corpus of 40 research articles in Molecular Biology and Organic Chemistry, written by Arab L2 and Native English (NE) writers. The analysis reveals a stark, statistically significant divergence in the frequency and distribution of these resources: Arab L2 …

An Analysis Of Developmental Changes In Twitch Patterning During Rem Sleep, Claire Wolfer-Jenkins, Taylor Svoboda

The Journal of Purdue Undergraduate Research

No abstract provided.

Straw Cover Increases Garden Soil Microbial Biodiversity, Emory Walker, Mara Welty, Emma Creviston

The Journal of Purdue Undergraduate Research

No abstract provided.

Using Neural Networks To Predict Microstructure Evolution In Granular Materials, Prashant Rajesh Iyer

The Journal of Purdue Undergraduate Research

No abstract provided.

A Qualitative Analysis Of Cyclical Patterns In Bobcat Movement In Relation To Seasonal Flooding And Species Life History, Sierra A. Hunnicutt

The Journal of Purdue Undergraduate Research

No abstract provided.

The Evolution Of Tyrosine Kinase Activity And Chance, Contingency, And Necessity In Evolution, Michael Gardner

The Journal of Purdue Undergraduate Research

No abstract provided.

Computational Analysis Of Calcium Binding Sites In Calmodulin And Their Role In Activating Adenylyl Cyclase 1, Shreya Krishnan

The Journal of Purdue Undergraduate Research

No abstract provided.

Making A Splash: Using Mass Spectrometry To Measure Dopamine And Serotonin Activity In Brains Of Water-Enriched Pekin Ducks, Nina Wilson

The Journal of Purdue Undergraduate Research

No abstract provided.

Validation Of Innovative Method Of Murine Vertebral Compression Testing, Sarah Staller

The Journal of Purdue Undergraduate Research

Murine vertebral compression testing is a common technique to quantify trabecular bone biomechanics. Having a precise method of vertebral compression is important for aiding researchers in making clinically relevant discoveries in musculoskeletal research. While many methods exist in literature, there has yet to be established a universal protocol for this procedure. Many challenges exist in vertebral compression, such as the irregular shape of the vertebral body (trabecular region of interest), uneven endplate surface morphology, and surrounding cortical processes. Therefore, the aim of this study was to develop a new method of vertebral compression that accounts for these factors and to …

Just "Beet" It? A Comparison Of Road Salt Effects On The Life History Of Daphnia Magna, Koby Sellner

The Journal of Purdue Undergraduate Research

In areas that experience snow and ice, deicing reagents such as road salts are often used on roads to promote safer driving conditions. However, road salts run off into local vegetation, soil systems, and (my focus) freshwater systems. The impacts of excess salt and chloride in freshwater have been studied extensively on a broad diversity of organisms under different conditions, but previous studies have rarely used different types of road salts. Zooplankton are primary consumers in many freshwater systems, feeding on phytoplankton and serving as prey for predator species higher in the trophic chain. These animals generally are impacted negatively …

The Automation Of Lamp Biomolecular Assays Using The Eppendorf Epmotion™ 5075 Robotic Pipettor, Shamalaa Sathiasealan

The Journal of Purdue Undergraduate Research

Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique known for its specificity and efficiency in less controlled environments than laboratories. Designing novel LAMP reagents requires strict contamination control, and unlike the more commonly automated polymerase chain reaction, LAMP’s heightened sensitivity poses unique challenges to automation. To address this, we optimized automation procedures for LAMP using a robotic pipettor without altering the core assay itself. This project focuses on minimizing contamination using sealed plates, reducing operator intervention by automating pipetting, and preventing enzyme degradation using cooling plates. Our approach employs pre-slit pierceable seals and cooling blocks to prevent cross-contamination …

Effects Of Alcohol Exposure On Recognition Memory And Marble-Burying Tasks In Male And Female Aged Mice, Roma Kamat, Tori Burke

The Journal of Purdue Undergraduate Research

Alcohol consumption in aging humans is a risk factor for cognitive impairment. This experiment assessed the effects of binge-like alcohol drinking in aged mice on memory (using the object recognition memory [ORM] task) and on anxiety-and compulsive-like behavior (using the marble-burying task). Subjects were 8 female and 10 male mice, 14–15 months old, selectively bred for low alcohol preference (LAP). Mice consumed either tap water or a 20% alcohol (v/v) solution in tap water through a drinking in the dark (DID) procedure for 4 consecutive days per week, for 3 consecutive weeks. One and 11 days after DID, mice completed …

The Due Process And Policy Implications Of The Laken Riley Act, Abigail Adu

University of Cincinnati Law Review

No abstract provided.

Enabling Unpredictability And The Perils Of Judicial Science And Math In Ohio V. Epa, Neil Taylor, Bradford Mank

University of Cincinnati Law Review

No abstract provided.