Digital Commons Network^™

Yx0798 Is A Highly Potent, Selective, And Orally Effective Cdk9 Inhibitor For Treating Aggressive Lymphoma, Vivian Jiang, Yu Xue, Hong Kim, Qingsong Cai, Tianci Zhang, Lei Nie, Joseph Mcintosh, Yang Liu, Haiying Chen, Jia Zhou, Michael Wang

Faculty, Staff and Student Publications

Nongenetic transcription evolution has been increasingly explored and recognized to drive tumor cell progression and therapeutic resistance. As the regulation hub of transcription machinery, cyclin-dependent kinase 9 (CDK9) is the gatekeeper of RNA polymerase II transcription, and CDK9 dysfunction results in transcriptomic reprogramming and tumor cell progression. We recently reported that the heat shock protein 90 (HSP90)-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma (MCL) through transcriptomic reprogramming. We also showed that targeting CDK9 by AZD4573 and enitociclib is a safe and effective treatment in preclinical Mantle Cell Lymphoma (MCL) models, supporting CDK9 as a valid therapeutic target for …

Corrected Amicus Brief Filed By Amici Curiae Law Professors In 25-11612 & 25-11821, William Snape, Delicianna Winders, Patrick Parenteau, Christopher Courchesne, Hope Babcock, Holly Doremus, Paul Boudreaux, Oliver A. Houck, Zygmunt J.B. Plater, Michelle Benedict Nowlin, Daniel Rohlf

Amicus Briefs & Court Filings

STATEMENT OF THE ISSUES: Whether the district court's injunction requiring FDEP to cease Endangered Species Act-violating conduct, obtain an incidental take permit before it continues with the conduct, and implement reasonable protective measures violates principles of cooperative federalism, the Tenth Amendment, or the anti-commandeering doctrine.

Antibiotic Treatment Limits Survival Of Peripheral And Bone Marrow B-Cell Populations, Lila S Sanning, Forrest C Walker, Arushana A Maknojia, Leran Wang, Haina Jin, Gowri Kalugotla, Crystal Lovato, Katherine Y King, Megan T Baldridge

2020-Current year OA Pubs

Prolonged or broad-spectrum antibiotic courses are associated with intestinal dysbiosis and cytopenias, and depletion of hematopoietic progenitor populations after antibiotics is associated with loss of peripheral immune cells, leading to increased susceptibility to systemic infections. We evaluated the bone marrow hematopoietic compartment in a murine model of antibiotic exposure. Single-cell RNA sequencing revealed a substantial and previously unrecognized depletion of bone marrow B cells at all stages of development in antibiotic-treated mice, further confirmed by flow cytometric analysis. Depletion of the microbiota was associated with rapid changes in the peripheral B-cell compartment, yet fecal microbiota transfer did not rescue either …

Modeling Neurodegeneration In The Retina And Strategies For Developing Pan-Neurodegenerative Therapies, Emily L Ward, Aaron Diantonio, Et Al.

2020-Current year OA Pubs

BACKGROUND: Glaucoma Research Foundation's third Catalyst for a Cure team (CFC3) was established in 2019 to uncover new therapies for glaucoma, a leading cause of blindness. In the 2021 meeting "Solving Neurodegeneration," (detailed in Mol Neurodegeneration 17(1), 2022) the team examined the failures of investigational monotherapies, issues with translatability, and other significant challenges faced when working with neurodegenerative disease models. They emphasized the need for novel, humanized models and proposed identifying commonalities across neurodegenerative diseases to support the creation of pan-neurodegenerative disease therapies. Since then, the fourth Catalyst for a Cure team (CFC4) was formed to explore commonalities between glaucoma …

Needs Analysis Of Interactive Learning Media For Teachingheat Transfer In Physics: Students’ And Teachers’Perspectives, Rizki Eka Shintya, Ika Mustika Sari, Ida Kaniawati

Jurnal Pendidikan Sains

Heat transfer material in physics is known to be abstract. This study specifically analyzes the conceptual difficulties, and visualization needs specific to this material, which is different from the analysis of physics needs in general. This analysis does not only look for the need for traditional media but explicitly looks for the need for interactive media (simulation, animation, virtual laboratory). Therefore, this study aims to identify the need for interactive learning media in physics education, specifically in the teaching of heat transfer, from the perspective of students and teachers in West Java, Indonesia. Using a quantitative descriptive survey, data were …

A Comprehensive Approach Addressing The Most Chronic And Emerging Contaminants Along The Egyptian Mediterranean Coast, Tarek O. Said

Blue Economy

Newly identified substances known as emerging contaminants (ECs) are harmful to the environment and public health, frequently because limited regulation and incomplete understanding of their impacts. They comprise a broad variety of materials, such as insecticides, industrial wastes, personal care items, and medications. Persistent pollutants (POPs) are organic compounds that have remained in the environment for an extended period of time. They tend to move through the atmosphere over enormous distances making them a chronic contaminant and may harm ecology and humanity over time. In Egypt, particularly within its Mediterranean Exclusive Economic Zone (EEZ), heavy metal (HM) contamination is increasingly …

Incorporating An Innovative Kennel In A Guide Dog Program Based On The Health And Welfare Of Dogs And Humans, Naoko Koda, Miwa Murata, Sakura Mizuta

People and Animals: The International Journal of Research and Practice

During guide dog training, dogs live in kennels and lack house training. The demand for guide dogs that can live easily with their users who are visually impaired is increasing. The Kansai Guide Dogs for the Blind Association (KGBDA) in Japan built an innovative wooden kennel (Mokka Terrace) that is more similar to homes than general kennels and that efficiently controlled dogs and reviewed their operations. This study conducted a literature survey, participant observations, and semi-structured interviews with staff to clarify the background and consensus-building process involved in creating the Mokka Terrace, corresponding efforts, and its strengths, issues, and prospects. …

2024 American Field Ornithologist (Afo) And Western Bird Banding Association (Wbba) Joint Annual Meeting Scientific Abstracts, Walter H. Sakai

North American Bird Bander

No abstract provided.

Utilitarianism, Dune, And The Moral Problem Of Genetic Engineering, Mathias W. Alling

Quest

Moral Philosophy Essay

Research in progress for PHIL 2306: Introduction to Ethics (Honors)

Faculty Mentor: John Macready, PhD

This article began as a research essay during the Fall 2024 semester for my honors- level course, Introduction to Ethics (PHIL 2306). In this course, students are asked to research a moral issue and offer an argument for whether the issue is morally required, morally permitted, morally permissible, or morally impermissible. Mathias Alling’s philosophically ambitious article “Utilitarianism, Dune, and the Moral Problem of Genetic Engineering” examines the moral permissibility of genetic engineering through the fictional universe of Frank Herbert’s novel Dune …

Skin Cancer Image Classification Using Deep Learning With Data Segmentation Technique, Akhilesh Kumar Shrivas, Hema Vastrakar

Karbala International Journal of Modern Science

The human skin is an impressive organ and structural element often impacted by a diverse range of recognized and unknown diseases. Diagnosing disorders that affect the outermost layer of the body is the most uncertain and difficult component in the scientific field. Dermatological diseases are one of the most significant health concerns in the 21st century since their identification is challenging and costly, plagued with challenges and the subjectivity that comes with human interpretation. The main objective of this piece of research work is to develop a robust model for the classification of skin cancer diseases using deep convolution neural …

A Recent Insight On Prevalence Of Atopic Diseases In Children With Type 1 Diabetes, Randa Mohamed Darwish, Ayat Ibrahim Ghanem

Journal of Medicine in Scientific Research

Background Type 1 diabetes mellitus (T1DM) and atopic diseases are both prevalent immunemediated conditions in children. Although traditionally viewed as immunologically opposing disorders—T1DM being Th1-mediated and atopy Th2-mediated—recent studies suggest possible overlap in genetic susceptibility and environmental triggers. This study aimed to evaluate the prevalence and association of various atopic conditions in pediatric T1DM patients. Aim of the study To investigate the prevalence of atopic diseases—including atopic dermatitis, allergic rhinitis, allergic conjunctivitis, bronchial asthma, food allergy, and anaphylaxis—among children with T1DM compared to healthy age- and sex-matched controls, and to analyze contributing risk factors. Methods A retrospective cohort study was …

The Daily Gamecock: October 2025, University Of South Carolina, Office Of Student Media

2025

No abstract provided.

Help Light Up A Child’S Holiday, Office Of Diversity, Equity, And Inclusion, Office Of Human Resources, Office Of Student Life, Student Bar Association

Student Organizations

October 13-December 4, 2025

Organism-Specific Sequence Motifs Link Ribosomal Rnas To Brain Disorders, Isidore Rigoutsos, Stepan Nersisyan, Eric Londin, Iliza Nazeraj, Bonnie Dong, Anastasios Vourekas, Phillipe Loher

Computational Medicine Center Faculty Papers

We report that in humans, mice, fruit flies, and worms, the ribosomal RNAs and the transcribed spacers of 45S are densely packed with organism-specific sequence motifs that are primarily shared with nervous system genes. The human ribosomal RNAs and 45S spacers contain 1,723 such motifs. Specific combinations of these motifs are predominantly found in 3,430 human nervous system genes, of which 1,046 are genes associated with brain disorders, including autism spectrum disorder and schizophrenia. The sequences of the 1,723 motifs and their locations in the introns and exons of nervous system genes are unique to primates. Experimental evidence indicates that …

Development Of Natural Product Analogs As Therapeutic Agents, Jacob Mara

Theses and Dissertations

Cancer stem cells (CSC) are cancer cells in a tumor mass that may self-renew and develop into various cell types, resulting in a heterogeneous tumor. CSCs have been shown to have a role in many facets of cancer formation, including tumor genesis, proliferation, and metastatic activity. They are also implicated in chemotherapeutic treatment resistance and the recurrence of some malignancies. Based on these capacities, CSCs have been identified as the next target for cancer therapy and control. Salinomycin's potential for therapeutic use based on ongoing research, as well as the synthesis of its derivatives and their biological activity, will also …

Chimes: October 13, 2025, Calvin University

Chimes

Creation care on Calvin's campus by Maya Oeverman

Breaking new ground: Calvin's ecosystem preserve adds a rock garden by Ian Tjoelker

Break-in News: Deer in Boer Bennink Kitchen by Maya Oeverman

A story worth seeing: Calvin's The Glass Menagerie by Ellery Johnson

Donald Trump vs. John Calvin by Joe Toly

Ode to the fallen deer by Marcail Schuurmann

Proteomic Characterization Of The Neuronal Bin1 Interactome In Homeostatic And Alzheimer’S Disease Mouse Brains, Joseph Mcmillan

USF Tampa Graduate Theses and Dissertations

The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer’s disease (LOAD). It is expressed in neurons and glia in the brain as cell-type specific and ubiquitous isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in many cell types. Previously, we reported that BIN1 predominantly localizes to presynaptic terminals in neurons and regulates presynaptic vesicular release. However, the function of neuronal BIN1 in relation to LOAD is not yet fully understood. A significant gap in the field is the unbiased characterization of neuronal BIN1-interacting proteins and proximal neighbors. To address this gap and help define the …

The Cardioprotective Effects Of Adiponectin In Diabetes., Tara Kazemi, Yuanjie Mao, Tina Zhang

Ambulatory and Primary Care Articles

PURPOSE OF REVIEW: Adiponectin, a hormone secreted by adipocytes, plays a crucial role in maintaining metabolic balance and supporting cardiovascular health. Although it is known for its protective effects, such as improving insulin sensitivity, reducing inflammation, and maintaining endothelial function, there are paradoxical associations between high adiponectin levels and increased cardiovascular mortality-referred to as the "adiponectin paradox"-which complicates its clinical interpretation. This review explores the cardioprotective effects of adiponectin in both type 1 and type 2 diabetes, focusing on its potential to regulate glucose metabolism and prevent cardiovascular complications.

RECENT FINDINGS: By reviewing key studies, the article evaluates adiponectin's diverse …

Managing Chickens From Chicks To Peak Egg Production, Joseph Okoh, Essence Perry

All Current Publications

Chickens were first domesticated for cultural purposes, but selective breeding has focused on egg production. Choosing the right breeds and good management practices are essential for farmers to maximize egg yield, quality, and safety. This fact sheet covers poultry history, top egg-laying breeds, egg anatomy, nutrition, and practical tips to help farmers improve productivity and run successful egg production ventures.

Ndls Communicator: Week Of 10.13.25, Notre Dame Law School

NDLS Communicator

The Latest News

• Lady Chief Justice of Northern Ireland Siobhan Keegan talks about life and the law at Notre Dame
• Wrongful Conviction Day
• Annual Red Mass
• Notre Dame Law Students Assist with UN Report on Religious Freedom for People on the Move

Faculty Briefs

• Nicole Garnett
• Patrick Corrigan
• Roger Alford
• Mary Ellen O'Connell
• Jen McAward
• Haley Proctor
• Rick Garnett
• Derek Muller
• Gerard Bradley

ND Law in the News

• The Law School's recent panel, "How Does Catholic Social Teaching Animate Human Rights in Africa," was mentioned in Irish Legal Network's Rights Watch. Events

Events

• Law and Economics Workshop
• SCOTUS Term Preview …

A Farmer's Guide To Egg Quality, Safety, And Flock Health, Joseph Okoh, Essence Perry

All Current Publications

Eggs are a valuable source of nutrition and income for many backyard and smallholder farmers. To ensure a steady supply of high-quality eggs, it's essential to understand the key factors that influence hens’ health and productivity. From proper nutrition to effective lighting and disease prevention, each decision you make affects your flock’s performance. This guide offers practical advice to help you raise resilient, high-laying hens and build a successful small-scale egg production system, no matter your level of experience.

Inhibition Of Osteosarcoma Lung Metastases By Β-Glucan And Cd40 Agonist Is Mediated By Activation Of Macrophages And Nk Cells, Pradeep Shrestha, Rejeena Shrestha, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: Osteosarcoma (OS) lung metastases remain a significant therapeutic challenge. Innate immune activation is a promising therapeutic approach. Innate immune agonists can modulate the tumor immune microenvironment and improve therapeutic response.

Methods: Using an experimental syngeneic OS lung metastasis BALB/c mouse model with K7M3-luc OS cells, we evaluated the antitumor effects of yeast-derived particulate β-glucan in prevention and therapeutic settings. We then assessed whether the CD40 agonist (CD40a) in combination with β-glucan increased therapeutic response in two different immune-competent mouse models of OS lung tumor burden.

Results: In the pretreatment settings, mice treated with β-glucan prior to OS cell infusion …

Singing A Wide Heart: Timbre And Sung Prayer In Senegal’S Layène Community, Margaret L. Rowley

Yale Journal of Music & Religion

Layène sung prayer (called sikkar) is embedded within the religious practices of the Layène community, a minority Sufi order in Dakar, Senegal. This article explores the functions of Layène sung prayer, focusing especially on its loud, vibrational timbre. Both men and women vocalists in call-and-response sing loudly, using wide vibrato and electronic amplification to ensure that the sikkar reaches the inhabitants—both human and non-human—in the surrounding community. This article demonstrates that the distinctive timbre of Layène sung prayer serves the spiritual functions of binding the community together in spiritual and social cohesion, increasing individual and collective generosity, and demarcating …

Live Wires: The Angelus Temple And The Timbre Of Power, Catherine Provenzano

Yale Journal of Music & Religion

This article is a media history and contemporary case study of The Angelus Temple in Los Angeles, founded by Aimee Semple McPherson in 1923. My analysis of the Angelus insists upon the centrality of a hyperaudible paradigm of worship that uses media to maximize the legibility of a Christian message, and, more than this, imagines that media itself as a living soul in need of redemption. Many contemporary megachurches employ savvy applications of sound and sound transmission as instruments of belonging as well as action, and these rely on high-budget investments in church infrastructure, software and personnel. I argue that …

From The Heaviest, Dirtiest Depths To The Washy Ambient Clouds: Guitar Timbre In/As Schismogenesis In North American Christianity, Joshua K. Busman, Nathan Myrick

Yale Journal of Music & Religion

This essay argues that within the socio-cultural context of North American Christianity, the timbral qualities of electric guitar, with its long lineage as a site of cultural values conflict and identity negotiation, serves a theological function in the emerging and cohering sonority of digital worship. Using as comparative case studies the timbral qualities of delay and ambience as promoted and sold by Worship Tutorials as representing normative sonic values for these Christians, on the one hand, and the dialectic and schismatic deployment of distortion by the band My Epic on the other, we suggest that these timbral qualities become important …

Introduction: The Power Of Timbre In Religion, Bo Kyung Blenda Im, Nathan Myrick

Yale Journal of Music & Religion

How might attending to timbre shift the boundaries of the experiences and practices that come under the analytical purview of religion? What timbral qualities render prayer efficacious and invite divine encounter? What cosmological claims and social relations are forwarded through sounds invoked in religious rituals and gatherings? How do marginalized voices and instruments shape worshipping communities? On the other hand, how are dominant identities and attendant structures reified through religiously marked timbre? Such questions about the character of sounds and their implications for religion animate this issue of the Yale Journal of Music & Religion.

Dynamics Of Infanticides Among The Ngoni Of Tanzania, 1850s-1916, Andrew S. Kasambala, Oswald J. Masebo

Zamani: A Journal of African Historical Studies

Infanticide is one of the key factors in explaining changes in human populations since the antiquity. This paper examines dynamics of infanticide practices among the Ngoni of Tanzania from the late pre- colonial to the end of German colonial rule in 1916. Relying on primary and secondary sources, it argues that while infanticide remained a critical problem in Songea from the 19th century to the end of German colonialism in 1916, the context in which it was practiced and the interventions devised to alleviate it changed over time. While it was primarily practiced in Songea by pre-Ngoni communal based clans …

Swine Origin Probiotics That Promote Health And Growth Performance In Pigs, Jiangchao Zhao, Xiaofan Wang, Tsungcheng Tsai, Charles V. Maxwell

Patents Granted

The present invention provides probiotic compositions comprising isolated bacterial strains, referred to herein as LactX, StrepX1 and StrepX3. Methods of using the compositions to increase growth rate in pigs and enhance pig production are also provided.

Functional Roles Of The Complement Immune System In Cardiac Inflammation And Hypertrophy, Kathryn D Hok, Haydn E Rich, Anthony Shadid, Lavanya Gunamalai, Tingting Weng-Mills, Rajarajan A Thandavarayan, Nirmal K Banda, Marie-Francoise Doursout, Marcos I Restrepo, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Cardiac inflammation and hypertrophy develop as a pathologic response to an array of insults, such as myocardial infarctions, chronic systemic hypertension, and valvular defects. Due to the high prevalence of such conditions, there is an increasing need to prevent and halt cardiac hypertrophy. Because cardiac damage and subsequent remodeling can lead to arrhythmias, heart failure, and even sudden cardiac death, inhibition of cardiac hypertrophy is key to reducing cardiovascular-related mortality. The immune system is the driving force behind inflammatory reactions. All three pathways of complement system activation-classical, lectin, and alternative-are implicated in developing cardiac damage, inflammation, and hypertrophy due to …

Emotional Intelligence Training Correlates With Medical Students’ Apprehension Of Ai In Healthcare: A Single-Institution, Observational Study, Austin P. Runde, Shambhavi Mishra, Marina Feffer, Ramzan Shahid

School of Medicine

Background: The use of artificial intelligence (AI) in healthcare is becoming increasingly widespread. While AI has been touted to improve many aspects of the field, its potential to undermine the doctor-patient relationship has also been recognized. It is not known what future physicians believe regarding the potential effects of AI on physicians' professional relationships. It is also unknown whether formal training in emotional intelligence (EI) and resilience strategies influences medical students' opinions on the use of AI in healthcare.

Objective: To ascertain medical students’ opinion on the potential impact of AI on various EI-related aspects of healthcare, such as its …