Digital Commons Network^™

Menin Inhibitor Ds-1594b Drives Differentiation And Induces Synergistic Lethality In Combination With Venetoclax In Acute Myeloid Leukemia Cells With Rearranged Mixed-Lineage Leukemia And Mutated Nucleophosmin-1, Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A Milne, Marina Konopleva

Faculty, Staff and Student Publications

Mixed-lineage leukemia (MLL) rearrangements and Nucleophosmin-1 (NPM1) mutations are associated with acute leukemias whose pathogenesis is critically influenced by protein-protein interactions between menin and MLL. We hypothesized that targeting the menin-MLL interaction using DS-1594b and blocking the antiapoptotic BCL-2 protein using venetoclax may promote differentiation and enhance eradication of MLL-rearranged and NPM1-mutated leukemias models. We treated acute myeloid leukemia (AML) cell lines with MLL rearrangements, NPM1 mutations, other leukemias and primary samples from AML patients with venetoclax alone, DS- 1594b alone, and their combination. We measured proliferation, viability, apoptosis, and differentiation using a variety of cellular assays, Western blotting, and …

A Collaborative Approach To Marine Species Tracking: Insights From The Fish Intel Acoustic Telemetry Network, Alice E. Hall, Tom Stamp, Peter Davies, Mathieu Woillez, Martial Laurans, Marine Gonse, Lydie I.E. Couturier, Olivier Blanpain, Katia Frangoudes, Emmanuelle Quillérou, Eider Graner, Jan Reubens, Carlotta Muñiz, Lucy A. Hawkes, Matthew J. Witt, Thomas W. Horton, Tom Hooper, Ricky Pender, Erwin Quemeneur, Mewen Abjean, Xavier Tetard, Pascal Provost, Silvana Birchenough, Jean Luc Solandt, Colin Trundle, Amy Y. Cartwright, Sian Rees, Ronan Conlon, Shion E.A. Reynell, Ben Ciotti

School of Biological and Marine Sciences

Acoustic telemetry offers valuable insights into species' spatial and temporal movement patterns, helping to understand habitat use, behaviour and migration timings. The Fish Intel Network established a collaborative cross-English Channel acoustic telemetry network to track multiple species over small and large spatial scales. This network was designed in close alliance with local fishers to incorporate essential local ecological knowledge of target species and habitats, gathered through interviews and workshops. To date, 254 acoustic receivers have been deployed, and 874 animals have been tagged across the Channel. Six species were tracked for this study: European bass (Dicentrarchus labrax), pollack (Pollachius pollachius), …

Mechanisms Of Antibody-Mediated Protection In Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Samantha Mackin

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATION Mechanisms of Antibody-Mediated Protection in Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Samantha Rae Mackin Doctor of Philosophy in Biology and Biomedical Sciences Immunology Washington University in St. Louis, 2025 Professor Michael S. Diamond, Chair Coronaviruses (CoVs) are enveloped, non-segmented, positive-sense RNA viruses belonging to the Coronaviridae family. The subfamily Coronavirinae includes four genera: alpha-, beta-, gamma-, and deltacoronaviruses. While gamma- and deltacoronaviruses primarily circulate in wild or domestic birds and have shown the potential for cross-species transmission, alpha- and betacoronaviruses mainly infect mammals, resulting in respiratory illnesses that can be mild or severe. Over …

Applying The One Health Approach To Study The Policy And Institutional Determinants To Control And Prevent Zoonoses In A Low-Resource Setting, Lisset Dumet, Erin S. Kenzie, Veronika Merino, Vanessa Cruz, Ruth Atto, Percy Vilchez, Seth O'Neal, Julia Goodman

OHSU-PSU School of Public Health Faculty Publications and Presentations

Zoonoses - diseases transmitted between animals and people - disproportionally affect low-resource countries (LRCs). The complex nature of zoonoses adds substantial barriers to implementing multisectoral policies to address them. Research on the policy process could help illuminate the significant factors influencing policy change among the complex systems involved in managing zoonoses. We applied the One Health (OH) approach to describe the policy process among the systems involved in preventing and controlling zoonoses in Peru. The study's purpose is to (1) describe the priority-making process and the driving or limiting factors, (2) describe the process for selecting policy solutions and (3) …

Survival Analysis Of Breast Cancer Patients In Texas Using Classical And Machine Learning Methods, Sidketa Fofana, Tamer Oraby, Salique H. Shaham, Everardo Cobos, Manish K. Tripathi

School of Medicine Publications

Background

Breast cancer is considered one of the most common cancers in women worldwide. In this study, we used an 11-year cohort of malignant breast cancer survival data in Texas to investigate the factors that might explain why some breast cancer patients live longer than others.

Methods

We performed standard survival analyses, including generating Kaplan‒Meier survival curves, using the log-rank test, and applying Cox proportional hazards regression to identify the unique features of breast cancer patients and determine the main factors influencing long-term survival. We also conducted a Random Survival Forest analysis for classification and prediction. Finally, we used Mahalanobis …

The Gods Of The Dunes: The Diverse Spiritual Practices And Beliefs Of The Dunites, Amy Hart

Communal Societies

No abstract provided.

Volume 8 (2025) The Spanish Language, Language Variations, Cultures And Responsibility

International Journal on Responsibility

This issue reflects an intentional and profound commitment to linguistic inclusion, cultural diversity, and the shared responsibility of scholars to broaden the scope of academic dialogue beyond the boundaries of English. The essays collected here invite us to reimagine bilingualism not only as a communicative skill but also as a moral, social, and institutional responsibility.

Esta edición representa un compromiso intencional y profundo con la inclusión lingüística, la diversidad cultural y la responsabilidad compartida de ampliar los horizontes del diálogo académico más allá de los límites del inglés. Los ensayos aquí reunidos nos invitan a reimaginar el bilingüismo no solo …

Culinary Collections In The National Library Of Ireland, Joanne Carroll, Nora Thornton

European Journal of Food Drink and Society

The National Library has been collecting, preserving and making the documentary heritage of Ireland available to the public since 1877 and cares for over 12 million items today. In 1926 it became a legal deposit Library so by law one copy of each book and periodical published in the Republic of Ireland must be deposited here. The NLI also acquires books and manuscripts through purchases, such as auctions or private sales and we receive donations of materials into our collections, from individuals and organisations. The Library is made up of different departments including Published Collections, Special Collections and Digital Collections …

Breaking The Mould: The Origins Of Irish Farmhouse Cheese In The Countercultures Of The 1970s And 1980s, Finbar Deery

European Journal of Food Drink and Society

This article examines the origins of farmhouse cheese in Ireland, which began in West Cork in 1974 with the creation of Milleens by Veronica Steele. This new farmhouse cheese industry is an example of food production that had no comparable reference in Ireland at the time. The farmhouse cheese industry is examined as an expression of a growing countercultural movement on the island in the 1970s and 1980s. This paper argues that the re-emergence of small-scale cheese production in Ireland is one expression of broader changes in the country and is both connected to and instrumental in the development of …

The Battle To Brand And Market Irish Beef—1950–73, Declan O'Brien

European Journal of Food Drink and Society

This article examines the controversy around the marketing of Irish beef up to Ireland’s entry into the EEC in 1973. The internal industry wrangle simmered from the birth of the modern processing industry in the 1950s but burst into life following the collapse in beef farmer incomes in the late 1960s. The article will explore how the Department of Agriculture and successive ministers for agriculture sought to navigate a middle line between the conflicting positions of the farm organisations and meat factory owners. While the National Farmers’ Association (NFA) and the Irish Creamery Milk Suppliers’ Association (ICMSA) consistently called for …

Agricultural Extension In Ireland: A Century Of Continuity And Change, Mícheál Ó Fathartaigh, Áine Macken-Walsh, Monica Gorman

European Journal of Food Drink and Society

In 1901, Ireland had the largest publicly funded professional extension service – agricultural scientists helping farmers to farm better – relatively, in the world. Utilising a wide range of historical sources and contemporary data, this paper provides a snapshot of the education and work of Irish advisors and their extension activities then and now. It identifies what has changed and what has not, showing key influences on Ireland’s current advisory services. Education for advisors 100 years ago was characterised by gender segregation, with less capacity and diversity. Continuity in the work of advisors then and now is shown in a …

Why The Irish Don’T Eat Offal, Niall Toner

European Journal of Food Drink and Society

In the past fifty years or so, the diverse and colourful displays of animal offal and organ meats that used to be seen in butchers’ shop windows in Ireland, as well as in the UK and America, have all but disappeared. In Ireland, which has seen a gastronomic renaissance in more recent times, these traditional foodstuffs appear to have been slow to return to our plates. But have offal and organ meats a place in the future of the cuisine, and can the increased consumption of offal and organ meats, produced locally, contribute towards a more sustainable food production system, …

The History Of Dublin Coddle And Its Significance As Part Of Ireland’S Intangible Cultural Heritage, Sinéad Mcglynn, Máirtín Mac Con Iomaire

European Journal of Food Drink and Society

Dublin coddle is held in great affection by generations of Dubliners and is a significant cultural identifier, yet to date there has been little or no academic research into its historical origins. Dublin coddle is a divisive dish which appears to be linked with the capital city, with almost tribal associations, where other ‘tribes’ refuse to consume it. This study argues for the inclusion of Dublin coddle-making, a regional dish made with sausages, ham or bacon, potatoes and onions, as part of Ireland’s Intangible Cultural Heritage (ICH) as set out by the United Nations Educational, Scientific and Cultural Organization (UNESCO). …

Review Of Oneida Utopia: A Community Searching For Human Happiness And Prosperity, Lawrence Foster

Communal Societies

No abstract provided.

Review Of Hippie Family Values, Nancy Stein

Communal Societies

No abstract provided.

“Owned And Controlled By Negroes”: Allensworth And The Study Of Subnational Space, Amy Hart

Communal Societies

No abstract provided.

Communal Learning In The Socialist Context Of Jonestown, Edward Cromarty

Communal Societies

No abstract provided.

Apocalyptic Redemption And Utopian Resignation: How Visions Of Dystopia Made Community Impossible In Jonestown, Morgan Shipley

Communal Societies

No abstract provided.

The Paulsons Are Going To Be Millionaires, Mark K. Matheson

The Graduate Review

No abstract provided.

The Head-Direction Signal Is Generated From Two Types Of Head Direction Cells In Brainstem Nuclei, Ryan M. Yoder

Psychology

Head direction (HD) cells discharge based on an animal's directional heading. Computational models propose that a ring-attractor network across the connections between the lateral mammillary (LMN) and dorsal tegmental nuclei (DTN) underlies the signal's generation. These models contain neurons that encode either HD or angular head velocity (AHV), but also require cells that are sensitive to both parameters conjunctively (HD + AHV). Here we identify both types of HD cells in the LMN and DTN of female rats, with one population sensitive to AHV (both symmetric and asymmetric), and the other population insensitive to AHV. Notably, many HD + AHV …

Physics 2426 Lecture Slides Volume 2, Chapter 5: Electric Charge And Field, Raji Kannampuzha Ph.D.

Physics

Lecture slides for PHYS 2426 (University Physics II) were developed using OpenStax Physics Volume II and III from Rice University. These materials were created as part of Collin College’s 2023-2024 OER Faculty Development Grant. Supported by State Farm Insurance Company, these grants are designed to help faculty develop and integrate open educational resources (OER) into their classrooms and expand the use of OER. All materials were peer-reviewed by Collin College faculty and administrators as part of the grant process to ensure quality and alignment with course objectives.

A Data-Efficient Approach For Monitoring And Modeling Stream Nutrients, Wasif Bin Mamoon

Dissertations (1934 -)

Streams and rivers with excessive nutrients can compromise aquatic ecosystems, human health, and overall water resources. Precise, high-resolution measurements of nutrient concentrations are essential for pollution management programs; however, conventional monitoring methods frequently face limitations due to cost and sample restrictions. This dissertation aimed to advance the existing state-of-the-science nutrient monitoring and modeling approaches to reduce sampling requirements and model complexity. First, this study estimated the dimensionality and predictability of nutrient signals (NOx and TP signals), that describe the nutrient dynamics. The findings showed that nutrient data can be forecasted accurately for 1 to 5.5 months. Most of the signals …

Dairy And Food Science Student Newsletter, November 5, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

How Plants Defy Gravity, Olivia Y. Kim, Agatha Shaikhutdinova, Joshua Lee, Reece Sit, Daniel Yang, Aliyah Shams, Kathryn Choi, Esther Yoo

STEM for Success Showcase

This educational short book, written by students, uses creative descriptions to make biology and chemistry concepts engaging and easy to understand.

The State Of Our Streams: A Land Trust's Approach To Monitoring The Health Of Three Headwater Streams, Lauren Mcgrath

Sustainability Research & Practice Seminar Presentations

Lauren McGrath, Director of Watershed Protection Program, Willistown Conservation Trust, presents "The State of Our Streams: a land trust's approach to monitoring the health of three headwater streams."

The Lumberjack, November 05, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Ethnobotanical Surveys And Morphological Analysis Of Medicinal Plant Names In Lɔ́Mɔngo (Lomongo) C60 At The Elandisha Mavaolo Protected Area In Northeastern Democratic Republic Of Congo, Jean-Baptiste Grodya Musafiri, Jean-Bosco Njango Ngonda, Reddy Shutcha Ehata, Charles Kumbatulu Sita, Chrispina Alphonce, Helene B. Mavar Manga Sodila

Journal of Humanities and Social Sciences

The aim of this research is to contribute to the documentation of Lomongo, a Bantu language spoken in the Democratic Republic of Congo (DRC). In this study, we focused on two morphological aspects of medicinal plant names in Lomongo: nominal morphology and morpho-syntax. To collect data, we engaged with two categories of informants: primary informants (traditional healers) and secondary informants (native Lomongo speakers). Ethnobotanical and ethnolinguistic surveys were conducted in the “Elandisha” Mavaolo area through participant observation, semi-structured interview guides, audio recordings, and photographs. The plants identified were documented in situ with the assistance of botanists from "Matiti-Lisanga," an interdisciplinary …

Decoding Omens From Animal Calls And Sightings: An Ethnozoolinguistic Study Among The Iraqw Of Tanzania, Chrispina Alphonce

Journal of Humanities and Social Sciences

Understanding the interplay between cultural beliefs, language, and environmental signals is crucial for comprehending how communities engage with their natural surroundings. Despite existing research on cultural interpretations of natural phenomena, little is known about how animal calls and sightings specifically predict omens within the Iraqw community in Tanzania. This study examines the Iraqw ethnozoolinguistics of omens, focusing on their role in forecasting social events, both positive and negative, and on how these signals reflect the community’s cultural understanding. A qualitative research design was employed, with data collected through introspection, focus group discussions, and semi-structured interviews, grounded in ecosemiotic, ecolinguistic, and …

Morphological And Semantic Analysis Of Plant Names Attested In Hehe Language In Tanzania, Onesmo Simon Nyinondi

Journal of Humanities and Social Sciences

This paper examines the morphological structure of plant names in Hehe, a Bantu language spoken in the Iringa Region of Tanzania, specifically in the rural areas of Mufindi and Kilolo districts, involving 169 participants. Data were collected through free listings, field interviews (also known as walk-in-the-woods interviews), focus group discussions, and the analysis of written texts containing Hehe plant names. The study shows that Hehe plant names consist of a noun class prefix and a noun stem, with most falling into the 3/4 and 5/6 pairs. Some plant names are also categorised in the 7/8, mainly small plants, and 9/10 …

What Is In A Plant Name? A Semantic Analysis Of Indigenous Plant Names Among The Yao Of Southern Tanzania, Julius John Taji

Journal of Humanities and Social Sciences

This study investigates the meanings conveyed by indigenous plant names among the Yao of Masasi, southern Tanzania, whose native language is Chiyao (Bantu, P21). The study specifically explores what plant names communicate beyond functioning as tools for labelling and identifying. The data for the study were collected through semi-structured interviews and jungle-walk-and-identify methods and they were analysed using the framework of onomastics, particularly the area of phytonyms. The sample of the study consisted of nine native speakers of Chiyao from three villages in the Masasi District in Tanzania, namely Chiwata, Kanyimbi and Mkululu. The findings show that indigenous plant names …