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Articles 2341 - 2370 of 22991
Full-Text Articles in Entire DC Network
Face Card Declined: The Deepfake Threat To Biometric Security In Financial Systems, Hazel Fernandez
Face Card Declined: The Deepfake Threat To Biometric Security In Financial Systems, Hazel Fernandez
Washington and Lee Law Review Online
Once limited to entertainment and disinformation, deepfakes are now extending into the financial sector, where voice and facial impersonations exploit biometric authentication systems to facilitate fraudulent transactions. This evolution exposes gaps in existing legal and regulatory frameworks, raising critical questions about consumer protection and institutional safeguards. This Note argues for a reconceptualization of deepfake harms as both a privacy and a financial security issue. It examines the illusion of consent generated by synthetic impersonation and insufficient statutory protections. The analysis examines the patchwork of federal, state, and international laws governing data privacy and artificial media, highlighting the gaps that allow …
Estrogen And Obesity Synergistically Suppress Protein S Via Hif1Α, Enhancing Thrombosis Potential, Mohammad A. Mohammad, Narender Kumar, Sonali Ghosh, Ashley L. Paysse, Claudia Leonardi, Vijaya Pilli, Ma Lorena Duhaylungsod, Eric Lazartigues, Diana Polania-Villanueva, Sadaf Nouman, Logan A. Barrios, Rima Chattopadhyay, Rafika Yasmin, Alaina Guilbeau, Manoj Kumar, Tina H. Nguyen, Jovanny Zabaleta, Li Li, Luis Del Valle M.D., Mallory T. Barbier, Samarpan Majumder, Laurent O. Mosnier, Samarpan Majumder
Estrogen And Obesity Synergistically Suppress Protein S Via Hif1Α, Enhancing Thrombosis Potential, Mohammad A. Mohammad, Narender Kumar, Sonali Ghosh, Ashley L. Paysse, Claudia Leonardi, Vijaya Pilli, Ma Lorena Duhaylungsod, Eric Lazartigues, Diana Polania-Villanueva, Sadaf Nouman, Logan A. Barrios, Rima Chattopadhyay, Rafika Yasmin, Alaina Guilbeau, Manoj Kumar, Tina H. Nguyen, Jovanny Zabaleta, Li Li, Luis Del Valle M.D., Mallory T. Barbier, Samarpan Majumder, Laurent O. Mosnier, Samarpan Majumder
School of Graduate Studies Faculty Publications
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality, with risk heightened in premenopausal women with obesity or use estrogen-based oral contraceptives. When both risk factors are present, the thrombosis risk increases substantially. Protein S (PS), an essential anticoagulant cofactor, is downregulated by both estrogen and obesity, but the molecular basis for this suppression remains poorly defined. We investigated the effect of estrogen and obesity on PS expression using plasma samples from 157 women stratified by BMI and contraceptive use, alongside 40 mice categorized as lean or obese with or without estrogen pellet treatment. The levels of PS …
Does Preoperative Arthritis Affect The Outcomes Of Superior Capsular Reconstruction? A Systematic Review, Tae-Hoon Park, Hyungsuk Kim, Sukil Kim, Jongin Lee, Gerald R. Williams, Hyun Seok Song
Does Preoperative Arthritis Affect The Outcomes Of Superior Capsular Reconstruction? A Systematic Review, Tae-Hoon Park, Hyungsuk Kim, Sukil Kim, Jongin Lee, Gerald R. Williams, Hyun Seok Song
Rothman Institute Papers
BACKGROUND: The optimal indications for superior capsular reconstruction (SCR) in cases of massive irreparable rotator cuff tears (RCTs) accompanied by degenerative arthritis remain controversial.
METHODS: A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Embase (Elsevier), and Google Scholar. Studies were included if they documented Hamada grade and reported clinical and radiographic outcomes after SCR for irreparable RCTs. American Shoulder and Elbow Surgeons (ASES) score, visual analog scale for pain (pVAS), active range of motion, and acromiohumeral distance (AHD) were analyzed.
RESULTS: In all 7 studies, there was no consistent …
Request For An Advisory Opinion By The State Of Guatemala On Democracy And Its Protection Under The Inter-American Human Rights System: Expert Opinion, Notre Dame Law School Global Human Rights Clinic, Notre Dame Reparations Design And Compliance Lab, Diane A. Desierto, Francisco J. Urbina, Paolo G. Carozza, Anibal Perez-Liñan, Faisal Yamil Meneses, Nicolas Buitrago Rey, Ian Sheppard, Michelle Vasquez, Nick Polk, Carlos Chinchilla Mourra, Jose Cardona Sanchez, Pablo Proaño, Roselis Diaz De Freitas, Zolile Shude, Christian Mikala-Ofori, Rachel Cooper
Request For An Advisory Opinion By The State Of Guatemala On Democracy And Its Protection Under The Inter-American Human Rights System: Expert Opinion, Notre Dame Law School Global Human Rights Clinic, Notre Dame Reparations Design And Compliance Lab, Diane A. Desierto, Francisco J. Urbina, Paolo G. Carozza, Anibal Perez-Liñan, Faisal Yamil Meneses, Nicolas Buitrago Rey, Ian Sheppard, Michelle Vasquez, Nick Polk, Carlos Chinchilla Mourra, Jose Cardona Sanchez, Pablo Proaño, Roselis Diaz De Freitas, Zolile Shude, Christian Mikala-Ofori, Rachel Cooper
Court Briefs
From Page 1
Notre Dame Law School Global Human Rights Clinic (NDLS GHRC) In collaboration with Notre Dame Reparations Design and Compliance Lab (ND Reparations Lab)
The undersigned Professors, staff lawyers, and researchers of the NDLS GHRC and the ND Reparations Lab respectfully submit this Expert Opinion for this Honorable Court’s consideration.
- The State of Guatemala has requested this Honorable Court to interpret specific provisions of the American Convention on Human Rights (e.g., Preamble first paragraph, Article 1 obligation to respect rights, Article 5 right to humane treatment, Article 8 right to a fair trial, Article 9 freedom from ex …
Cordmilk: Umbilical Cord Milking Versus Early Cord Clamping On Short-And Long-Term Outcomes In Neonates Who Are Non-Vigorous At Birth-Study Protocol Of A Multi-Center, Cluster-Randomized, Crossover-Controlled Trial, S. Yogeshkumar, Sunil S. Vernekar, Sangappa M. Dhaded, Kiran Talekar, Benjamin E Leiby, Rebecca Hartman, Yvonne Vaucher, Nitin Chouthai, Meenakshi Girish, Manish Jain, Shuchi Jain, Seema Parvekar, Vinita Jain, Alka Patankar, Milind Suryawanshi, Manish Tiwari, Manjushri Waikar, Nidhi Nashine, Deepali Ambike, Mahesh Asalkar, Rajesh Kulkarni, Sandhya Haribhaktha, Hemraj Narkhede, Sudha Chaudhari, Milind Kamble, Deepti Shrirame, Balchandra Falke, Seema Mehta, Asha Verma, Sunil Gothwal, Shivaprasad S. Goudar, Richard Derman, Anup Katheria, Zubair H. Aghai
Cordmilk: Umbilical Cord Milking Versus Early Cord Clamping On Short-And Long-Term Outcomes In Neonates Who Are Non-Vigorous At Birth-Study Protocol Of A Multi-Center, Cluster-Randomized, Crossover-Controlled Trial, S. Yogeshkumar, Sunil S. Vernekar, Sangappa M. Dhaded, Kiran Talekar, Benjamin E Leiby, Rebecca Hartman, Yvonne Vaucher, Nitin Chouthai, Meenakshi Girish, Manish Jain, Shuchi Jain, Seema Parvekar, Vinita Jain, Alka Patankar, Milind Suryawanshi, Manish Tiwari, Manjushri Waikar, Nidhi Nashine, Deepali Ambike, Mahesh Asalkar, Rajesh Kulkarni, Sandhya Haribhaktha, Hemraj Narkhede, Sudha Chaudhari, Milind Kamble, Deepti Shrirame, Balchandra Falke, Seema Mehta, Asha Verma, Sunil Gothwal, Shivaprasad S. Goudar, Richard Derman, Anup Katheria, Zubair H. Aghai
Department of Radiology Faculty Papers
BACKGROUND: Facilitating placental transfusion-the transfer of blood from the placenta to the newborn-via delayed cord clamping (DCC) or umbilical cord milking (UCM) at birth has been shown to improve iron stores in healthy term infants and may positively impact long-term neurodevelopmental outcomes. Infants who are non-vigorous at birth and at risk of developing hypoxic-ischemic encephalopathy (HIE) are particularly likely to benefit from placental transfusion. This process may offer neuroprotection by enhancing cardiopulmonary transition, supporting cardiac preload, improving systemic and cerebral perfusion, delivering stem cells and neurotrophic factors, and preventing iron deficiency. While DCC is not currently recommended for non-vigorous term …
Intercellular Signaling And Synaptic Deconstruction Uncovered By Single-Cell And Spatial Transcriptomics In An Ad Tauopathy Model, Jeff X. Ji, Brian L. Giles, Surjyadipta Bhattacharjee, Marie-Audrey I. Kautzmann, Alasdair P. Masson, Sonia Do Carmo, A Claudio Cuello, Nicolas G. Bazan
Intercellular Signaling And Synaptic Deconstruction Uncovered By Single-Cell And Spatial Transcriptomics In An Ad Tauopathy Model, Jeff X. Ji, Brian L. Giles, Surjyadipta Bhattacharjee, Marie-Audrey I. Kautzmann, Alasdair P. Masson, Sonia Do Carmo, A Claudio Cuello, Nicolas G. Bazan
School of Medicine Faculty Publications
Alzheimer's disease (AD) is the leading cause of dementia in elderly individuals worldwide; however, all mechanisms leading to disease onset and progression are not well understood. Here, we report brain single-cell multiome and spatial transcriptomics in a transgenic rat model of human-like tauopathy. We have identified new markers of tau-driven AD pathology and provided single-cell evidence for genes implicated in AD. Our findings reveal how tau hyperphosphorylation and aging alter ligand-receptor communication, transcription factor regulatory networks, and specific cellular networks. Notably, we found intriguing changes in cell communication involving glutamatergic transmission and Netrin signaling as a taupathy consequence. Overall, this …
The “I’M Too Much, Yet Never Enough” Paradox: A Critical Approach To Discourses Of Afro-Latinidad Among Second-Generation-Immigrant Women In South Florida, Eleni Victoria Webster
The “I’M Too Much, Yet Never Enough” Paradox: A Critical Approach To Discourses Of Afro-Latinidad Among Second-Generation-Immigrant Women In South Florida, Eleni Victoria Webster
Electronic Theses and Dissertations 2020 - Present
This study critically examines discourse and the ways it shapes identities and community belonging for self-identifying Afro-Latina, second-generation-immigrant women in South Florida. This qualitative research uses an intercultural communication framework to analyze interviews and collected poems. Informed by grounded theory and a Black feminist critical approach rooted in the intersectionality theory, the data is analyzed through comparative thematic and metaphorical rhetorical analyses. When discussing the discourses related to the development of ethno-racial identities for Afro-Latinas, certain communicative patterns of self-discovering, self-defining, and self-envisioning emerged. With regard to community belonging, three metaphorical discourses arose: not-enoughness, in-betweenness, and un-humanness. The internalization of …
Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz
Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz
Faculty, Staff and Student Publications
B lymphocytes play major adaptive immune roles, producing antibodies and driving T cell responses. However, how immunometabolism networks support B cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood. To gain insights, we systematically investigated acute primary human B cell transcriptional, translational, and metabolomic responses to B cell receptor (BCR), TLR9, CD40-ligand (CD40L), IL-4, or combinations thereof. T cell-independent BCR/TLR9 costimulation, which drives malignant and autoimmune B cell states, highly induced transaminase branched chain amino acid transaminase 1 (BCAT1), which localized to lysosomal membranes to support branched chain amino acid synthesis and mTORC1 activation. BCAT1 inhibition …
Policy Project: Creating An Animal Assisted Therapy Policy For A College Of Nursing, Brooke Peyton
Policy Project: Creating An Animal Assisted Therapy Policy For A College Of Nursing, Brooke Peyton
Doctor of Nursing Practice Projects
Nursing students experience high levels of academic stress, anxiety, and burnout, which can negatively impact learning, professional development, and overall health. Evidence indicates that Animal-Assisted Therapy (AAT) has the potential to impact stress levels, improve community connection, and enhance overall well-being among nursing students. Many academic institutions lack structured policies to guide AAT programs into educational settings. The purpose of this Doctor of Nursing Practice project was to develop a formal AAT policy for the College of Nursing with standardized procedures to implement an AAT program. Rogers’ Diffusion of Innovations theoretical framework was used to guide the development of the …
Cultural Innovation Can Increase And Maintain Biodiversity: A Case Study From Medieval Europe, Adam Spitzig, Manfred Rösch, Jessie Woodbridge, Martin Bauch, Piotr Guzowski, Peter Erhart, Ralph Fyfe, Elena Marinova, Adam Izdebski
Cultural Innovation Can Increase And Maintain Biodiversity: A Case Study From Medieval Europe, Adam Spitzig, Manfred Rösch, Jessie Woodbridge, Martin Bauch, Piotr Guzowski, Peter Erhart, Ralph Fyfe, Elena Marinova, Adam Izdebski
School of Geography, Earth and Environmental Sciences
Numerous research efforts have used paleoecological data to reconstruct past biodiversity in Europe. In these projects, researchers have identified increases in biodiversity over the Holocene and hinted at a positive correlation with human population. These are important findings but are not easily translated into effective biodiversity conservation and restoration policy. We argue that, in order to better inform policymaking, studies of past biodiversity dynamics should include analyses of contemporaneous cultural phenomena in order to identify and describe specific anthropogenic drivers of past biodiversity changes. We present an example here, a case study from the Lake Constance region (southwestern Germany), one …
Chimes: November 17, 2025, Calvin University
Chimes: November 17, 2025, Calvin University
Chimes
Budget cuts slash programs and faculty: Students react with grief and frustration by Sarah Sparling, Ian Tjoelker & McKenna Wilkinson
Bringing the Cretaceous to Calvin: Dice Museum reveals fossil and student artwork by Ellery Johnson
Recap: 200 students attend administration town hall by Sarah Sparling
Celebrating Calvin's Asian American and international populations by Jorie Cho
Calvin's D1 hockey on hot streak as they climb to #4 in national rankings by Hendrik Beelen & Zach Kern
Spotted turtles find their home on campus by Maya Oeverman
Student Senate allocates four thousand dollars to accessibility and sustainability projects by Ashley Hamons
Exploring Human Perception And Cognition In Expressing And Understanding Mechanical Designs, Yan-Ting Chen
Exploring Human Perception And Cognition In Expressing And Understanding Mechanical Designs, Yan-Ting Chen
Theses
Effective communication of mechanical designs through technical drawings requires geometric accuracy, efficiency, and an understanding of human perception and cognition. Although advances in computer-aided design (CAD) software have improved drawing precision and automation, current tools often overlook the spatial reasoning processes that users employ to interpret these representations. This study seeks to improve the accuracy and efficiency of human-computer interaction in CAD environments by examining how individuals perceive and interpret three-dimensional mechanical components within the context of technical drawings. A key focus is the identification of canonical and optimal views that align with intuitive human understanding. Through a series of …
Tlr2 Agonism Suppresses Myeloid Leukemogenesis By Reprogramming Leukemia Stem Cells, Michael E. Lawler, Jennifer S. Romer-Seibert, Michael S. Bowman, Ramkrishna Mitra, Christine M. Eischen, Robert L. Bowman, Sara E. Meyer
Tlr2 Agonism Suppresses Myeloid Leukemogenesis By Reprogramming Leukemia Stem Cells, Michael E. Lawler, Jennifer S. Romer-Seibert, Michael S. Bowman, Ramkrishna Mitra, Christine M. Eischen, Robert L. Bowman, Sara E. Meyer
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
The consequences of activated innate immune signaling in acute myeloid leukemia (AML) is not well understood. Using ligands directed at the toll-like family receptors (TLR) in models of high-risk AML, we uncover that TLR2 ligands exert unique antileukemic effects that are distinct from other TLRs. Although TLR2 signaling broadly induces inflammatory gene expression in AML cells, at the single-cell level, cell-type-dependent, divergent transcriptional responses coordinate cellular outputs of proliferation, differentiation, cell death, and activation of immune cell function. TLR2 ligands were the only TLR agonists capable of extending survival of AML-bearing mice through leukemia stem cell (LSC) reprogramming that elevated …
Ptbp1 Variants Displaying Altered Nucleocytoplasmic Distribution Are Responsible For A Neurodevelopmental Disorder With Skeletal Dysplasia, Aymeric Masson, Catherine Gooch, Et Al.
Ptbp1 Variants Displaying Altered Nucleocytoplasmic Distribution Are Responsible For A Neurodevelopmental Disorder With Skeletal Dysplasia, Aymeric Masson, Catherine Gooch, Et Al.
2020-Current year OA Pubs
Polypyrimidine tract-binding protein 1 (PTBP1) is a heterogeneous nuclear ribonucleoprotein primarily known for its alternative splicing activity. It shuttles between the nucleus and cytoplasm via partially overlapping N-terminal nuclear localization (NLS) and export (NES) signals. Despite its fundamental role in cell growth and differentiation, its involvement in human disease remains poorly understood. We identified 27 individuals from 25 families harboring de novo or inherited pathogenic variants - predominantly start-loss (89%) and, to a lesser extent, missense (11%) - affecting NES/NLS motifs. Affected individuals presented with a syndromic neurodevelopmental disorder and variable skeletal dysplasia with disproportionate short stature with short limbs. …
Salary Report, 2025 November, Eastern Michigan University
Salary Report, 2025 November, Eastern Michigan University
EMU Salary Reports
No abstract provided.
Preventive Transparency In Third-Party Litigation Funding, Seth Katsuya Endo
Preventive Transparency In Third-Party Litigation Funding, Seth Katsuya Endo
Northwestern University Law Review
For years, efforts to comprehensively regulate third-party litigation funding have been unsuccessful. But bills requiring mandatory disclosure are being introduced in Congress, and the Advisory Committee for Civil Rules has finally agreed to take up the issue. By grounding the discussion of third-party litigation funding in both the broader civil procedure and professional responsibility scholarship, this Article identifies an easy, uncontroversial reform to preventively address the categorical concerns raised by the practice. The primary contribution is a doctrinal intervention, identifying how legal ethics are an integral part of federal civil procedure and then drawing out the implications for third-party litigation …
Microplastic Variability In Wetland Sediments And Vegetation: A Case Study Of Spruce Bluff Preserve, Fl, Juana Maria Baudrix
Microplastic Variability In Wetland Sediments And Vegetation: A Case Study Of Spruce Bluff Preserve, Fl, Juana Maria Baudrix
Electronic Theses and Dissertations 2020 - Present
Plastic pollution has become an imminent threat to the environment and human health. This study explores the occurrence, distribution, and retention mechanisms of microplastics (MPs) in Spruce Bluff Preserve, a 97-acre freshwater wetland ecosystem located along the eastern bank of the St. Lucie River in Port St. Lucie, FL. Understanding MP dynamics in transitional freshwater ecosystem is crucial for environmental management efforts given Florida’s heavily fragmented and managed landscape. This research specifically examined the relationship between wetland vegetation and MP retention in sediments across different ecological zones within the preserve. Surface sediment samples were collected along 8 transects of varying …
Cephalopod Consciousness On “Their Own Terms”: Who Are “They”?, Willa M. Lane, Victor Ajuwon, Nicola S. Clayton
Cephalopod Consciousness On “Their Own Terms”: Who Are “They”?, Willa M. Lane, Victor Ajuwon, Nicola S. Clayton
Animal Sentience
Mather’s call to consider cephalopods’ consciousness “on their own terms” raises the question of the extent to which cephalopods can be considered a homogenous group. While coloeoid cephalopods share traits that strongly distinguish them from other molluscs and invertebrates, they show vast ecological and morphological diversity, with implications for the design of empirical investigations of consciousness. Extending Mather’s argument, we apply Birch et al.’s (2020) five-dimensional model to compare octopus, cuttlefish, squid, and nautilus. This comparison shows that even within a graded rather than categorical framework, putative consciousness profiles depend on which taxa are included in discussions of “cephalopod consciousness.” …
Data For Fermentation Research Guide Analysis, Laura Guengerich
Data For Fermentation Research Guide Analysis, Laura Guengerich
Morris Library Data Sets
No abstract provided.
Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3., Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner
Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3., Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner
Faculty Research 2025
Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …
Exploring The Effectiveness Of Virtual Reality Learning Through Use Of Visual Eye-Tracking Analytics (Veta) And Biological Measurements, Mckinley Anne Sherman
Exploring The Effectiveness Of Virtual Reality Learning Through Use Of Visual Eye-Tracking Analytics (Veta) And Biological Measurements, Mckinley Anne Sherman
Master's Theses
Virtual Reality (VR) offers an immersive and interactive platform for experiential learning. The purpose of this thesis was to evaluate the relationship between physiological responses and cognitive workload within a VR learning environment and to explore VR as an effective instructional tool. This research compared participant engagement, stress, and learning performance within a 6th-grade science module developed in VR by incorporating biometric data collected via Polar H10 heart rate monitor and Varjo Areo VR headset eye-tracking. Thirty-three participants completed a pre-lesson demographic survey, post-lesson survey, VR sickness questionnaire, and the NASA Task Load Index (NASA-TLX). While completing the lesson, the …
Antimicrobial Resistance And Transmission Risk Of Foodborne Escherichia Coli In Wet Markets, Sisi Li, Wei Zhou, Zhijin Zhou, Bin Wang, Chengjun Qiu, Zhangsheng Zhang, Qi Zhang, Yun Sun, Xu Xu, Tao Shen, Jianzhong Han, Daofeng Qu
Antimicrobial Resistance And Transmission Risk Of Foodborne Escherichia Coli In Wet Markets, Sisi Li, Wei Zhou, Zhijin Zhou, Bin Wang, Chengjun Qiu, Zhangsheng Zhang, Qi Zhang, Yun Sun, Xu Xu, Tao Shen, Jianzhong Han, Daofeng Qu
Journal of Food Science and Biotechnology
[Objective ] To evaluate the antimicrobial resistance and transmission risk of foodborne Escherichia coli in wet markets,this study isolated E.coli from pork,aquatic products,vegetables,and wastewater collected from three wet markets in Hangzhou,Zhejiang.[Method ] The isolates were identified by 16S rRNA sequencing,and their antimicrobial resistance phenotypes were determined via the disk diffusion method.PCR was employed to detect antimicrobial resistance genes and integrons in the isolates.The antimicrobial resistance characteristics of E.coli were analyzed,and conjugation experiments were performed to assess the potential for horizontal transfer of antimicrobial resistance genes.Co-occurrence network analysis was conducted to evaluate the transmission risk of antimicrobial resistance among the isolates.[Result …
Establishment Of A Molecularly Imprinted Electrochemical Sensor Nh 2-Mwcnts@ 4-Fpba For The Detection Of Epidermal Growth Factor In Dairy Products, Ruyue Zhang, Yiwei Wang, Hongxiu Zeng, Bini Wang, Fuxin Zhang, Zhenquan Huo, Yufang Liu
Establishment Of A Molecularly Imprinted Electrochemical Sensor Nh 2-Mwcnts@ 4-Fpba For The Detection Of Epidermal Growth Factor In Dairy Products, Ruyue Zhang, Yiwei Wang, Hongxiu Zeng, Bini Wang, Fuxin Zhang, Zhenquan Huo, Yufang Liu
Journal of Food Science and Biotechnology
[Objective ] This study aims to develop a rapid and accurate method for detecting epidermal growth factor (EGF ).[Method ] 4-Formylphenylboronic acid (4-FPBA ) was covalently anchored to the surface of aminocarbon nanotubes (NH 2-MWCNTs ) to synthesize nanocomposites (NH 2-MWCNTs@ 4-FPBA ),and NH 2-MWCNTs@ 4-FPBA was modified on a glassy carbon electrode.When EGF was present,4-FPBA captured the EGF template through benzaldehyde,and then the electrode was immersed in pyrrole solution to electropolymerize to form a pyrrole molecularly imprinted layer.Finally,after dissociation and removal of the EGF template in an acidic solution,a three-dimensional cavity complementary to the EGF template was formed.[Result ] …
Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao
Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao
Journal of Food Science and Biotechnology
[Objective ] This study aims to increase the caproic acid yield of Aneurinibacillus JXN- 1.[Method ] First,a Plackett-Burman design was employed to screen the significant factors affecting caproic acid yield from eight medium components.Subsequently,the path of steepest ascent method was used to determine the optimal concentration ranges of these significant factors.Finally,a Box-Behnken design was utilized to establish a quadratic polynomial regression model,and the interactions among the significant factors were analyzed to predict the optimal medium composition.[Result ] The Plackett-Burman design identified the mass concentration s of sodium acetate and calcium folinate and the volume fraction of ethanol as significant influencing …
A Stability-Indicating Validated Rp-Hplc Method For The Determination Of Etoricoxib And It’S Degradants: Investigation Of Greenness And Functionality Of The Developed Method, Lama Ghazal, Iyad Allous, Mhd Amer Almardini
A Stability-Indicating Validated Rp-Hplc Method For The Determination Of Etoricoxib And It’S Degradants: Investigation Of Greenness And Functionality Of The Developed Method, Lama Ghazal, Iyad Allous, Mhd Amer Almardini
Baghdad Science Journal
Etoricoxib is a novel NSAID that belongs to selective COX-2 inhibitors. The aim of this research is to develop a precise, selective, cost-effective, and validated HPLC analytical method for the quantitative determination of Etoricoxib and its degradants. The analysis was implemented on a C18 column (150 × 4.6 mm, 5 μm particle size) using a mobile phase containing methanol and ammonium acetate (60:40) at a flow rate of 0.9 mL/min, with the Photodiode Array detector wavelength set at 234 nm. The method was validated according to USP43-NF38 guidelines and the International Conference on Harmonization recommendations. Linearity was established with …
The Rs1611770 Snp Polymorphism And Expression Of Mucin One Gene In Infertile Females In Baghdad, Iman Hamed Diab Al-Janabi, Asmaa M. Salih Almohaidi, Ibrahim Jasim Hammadi Al-Janabi
The Rs1611770 Snp Polymorphism And Expression Of Mucin One Gene In Infertile Females In Baghdad, Iman Hamed Diab Al-Janabi, Asmaa M. Salih Almohaidi, Ibrahim Jasim Hammadi Al-Janabi
Baghdad Science Journal
Infertility is the inability to become pregnant after six months or more of consistent, unprotected sexual activity. There are several causes of infertility, including hormonal, genetic, and environmental factors. The current investigation focuses on the polymorphism of SNP rs 1611770 in Mucin one gene and expression in infertility, considering a few demographic variables including age, body mass index and circumference of the abdomen. The current study included 30 infertile females and 30 fertile females. The mean BMI recorded Significant differences 28.76 ± 0.85 for infertile and 25.99 ± 0.65 for fertile, There are no significant differences in age and abdominal …
Alirocumab In Dexamethasone-Induced Metabolic Syndrome: Therapeutic Benefits And Potential Hepatic Risks Through Rxr-Α / P-Akt Modulation, Miad A. Aljuhani, Mohamed S. Abdel-Bakky
Alirocumab In Dexamethasone-Induced Metabolic Syndrome: Therapeutic Benefits And Potential Hepatic Risks Through Rxr-Α / P-Akt Modulation, Miad A. Aljuhani, Mohamed S. Abdel-Bakky
Saudi Toxicology Journal
Background: Metabolic syndrome (MetS) elevates the risk of developing cardi-ovascular diseases and type 2 diabetes., driven by insulin resistance (IR), inflammation, and metabolic dysregulation. The PI3K/AKT pathway shows a key part in glucose and lipid metabolism. Alirocumab, a PCSK9 inhibitor, lowers LDL-C and improves IR but may cause hepatotoxicity. Aims: This study examines ali-rocumab’s effects on dexamethasone-induced MetS in rats, focusing on its metabolic benefits and potential liver toxicity. Methods: Over 30 days, 40 male Albino rats were distributed into control, Alirocumab, Dexamethasone, and Dexa-methasone+Alirocumab groups, with the latter receiving Dexamethasone to induce metabolic syndrome followed by Alirocumab administration. Results: …
The Impact Of Arginase1, Malondialdehyde Levels And The Activity Of Glutathione S-Transferase On The Development And Progression Of Diabetic Retinopathy In Some Iraqi Patients, Maha Faris Yaseen, Fayhaa M. Khaleel
The Impact Of Arginase1, Malondialdehyde Levels And The Activity Of Glutathione S-Transferase On The Development And Progression Of Diabetic Retinopathy In Some Iraqi Patients, Maha Faris Yaseen, Fayhaa M. Khaleel
Baghdad Science Journal
Diabetic retinopathy (DR) is the major cause of blindness due to microvascular damage from high blood glucose and lipid levels. Arginase1 is an enzyme that regulates β-cell activities, insulin resistance, and vascular complications, inflammatory responses, and oxidative stress. This study aimesto investigate the role of Arginase1 in Iraqi individuals with obesity, T2DM and DR and investigating the relationship with GST and MDA in the development of inflammation and oxidative stress that causes diabetic complication. This research included 120 participants: 40 obese controls, 40 diabetes Type 2 patients, and 40 diabetic retinopathy patients, aged 30–65, from both sexes. All groups …
A Study Of Dipeptidyl Peptidase-4 In Iraqi Patients With Coronary Artery Disease, Saja Taha Yissen, Layla Othman Farhan
A Study Of Dipeptidyl Peptidase-4 In Iraqi Patients With Coronary Artery Disease, Saja Taha Yissen, Layla Othman Farhan
Baghdad Science Journal
Heart and blood vessel illnesses are collectively referred to as cardiovascular diseases (CVD). Although there is, till now, no known cure for the deadly disease known as CAD, it is extremely predictable, treatable, and preventative. Dipeptidyl peptidase 4 (DPP4) is a single-pass transmembrane protein that regulates glucose levels and has several roles in the immune system, cell migration and proliferation, and other areas. The purpose of the study is to measure the DPP 4 levels in the sera of Iraqi patients with CAD. The DPP4 was measured in Iraqi patients' serum in the current investigation to evaluate, which included forty …
Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan
Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan
Baghdad Science Journal
The research includes the preparation of several complexes of the transition elements and zinc where M(II) = Co, Ni, Cu, and Zn, containing the 3d shell, with ligand (LH)was synthesized by treating the (Z)-3-hydrazineylidene-1-phenylpyrazolidine and Salicylaldehyde. Ligand (LH) was identified using FT-IR spectra,1H-13C-NMR, UV-Vis spectroscopy, elemental microanalysis CHN and mass spectrometry. The complexes were studied and identified with elemental microanalysis CHN, FT-IR spectroscopy, UV-Vis spectroscopy, conductivity measurement, and magnetic sensitivity. The result showed that, these complexes were classified as homogeneous tridentate complexes with the formula [M(LH) (H2O)2Cl] or [M(LH)2]. xH …