Digital Commons Network^™

Ontological Machines: Subjectivity And Relational Desire In Immersive And Interactive Environments, Toby Chanter

School of Art, Design and Architecture Theses

This practice-based artistic research focuses on two contemporary spaces; namely the pedagogical spaces of healthcare Simulation Based Education (SBE), and the exhibition spaces of installation art. These seemingly unrelated activities share a range of technological and operational similarities that render their combined study under the banner of ‘immersive and interactive environments’ both novel and necessary. The lack of broad engagement with questions of representation, aesthetics, and affect is conspicuous in an educational practice that is reliant on, and implemented through, a network of overtly visual mediums, material technologies, and sensory modalities. In healthcare SBE, clinical skills are acquired, and medical …

Grassroots Playwriting : Practice-Led Research Exploring The Impact Of Producing Historical Verse Drama For A Local Community, Chris Savery

School of Art, Design and Architecture Theses

Christ SaveryGrassroots Playwriting: Practice-led research exploring the Impact of Producing Historical Verse Drama for a local CommunityOver the past thirty years, Practice as Research has contributed to a deeper understanding of theatre ecology, particularly in relation to the complexities and nuances of grassroots community theatre. This study builds upon this body of knowledge by addressing the question: How can the creation and performance of a historical verse drama by a self-producing grassroots playwright serve as a catalyst for community engagement? Central to this thesis is the investigation into my role as a self-producing playwright within the context of grassroots theatre, …

Above And Below The Horizon: A Practice-Led Investigation Into Liminal Thresholds Of Bodies Of Water, Rachael Allain

School of Art, Design and Architecture Theses

This thesis contributes to the debate on the interactions between art, science, and phenomenological experience, whilst offering new possibilities for investigation in this interdisciplinary field. The research investigated thresholds of the aquatic horizon; the outline in the distance where sky and water appear to coalesce. Artistic practice and critical discourse challenged and interrogated the intersection between analogue and digital, still and moving technologies, revealing aspects of the physical and conceptual horizons within and beyond the visible light spectrum. A range of theoretical concepts reconfigured my readings and interpretations of the phases of experience, through liminality and phenomenology. This provided a …

The Problem Of Being The Problem: Creating Practice-Based Fieldworking Along Climate Vulnerable Coastlines, Kate Paxman

School of Art, Design and Architecture Theses

Focused on multisensory encounter with local semi-flooded sea caves and their communities in the crowded shores of Torbay’s Marine Conservation Zone, South West UK, this thesis questions how art and writing, made out of art-based practices of fieldworking (Crone et al., 2022), can respond to the threats posed to climate vulnerable coastal habitats from the global phenomenon of sea level rise. It asks, what is response, and how does an approach emerge from bodily encounters with fragile marine cave ecologies . Enquiring how acts of prolonged noticing can bear witness, the research considers what it means to be human in …

Artist Designed Systems In Community Radio, Lucinda Guy

School of Art, Design and Architecture Theses

Skylark is a full-time licensed radio station, founded by the author of this thesis. Since 2020 it has broadcast a continuous and ever-changing sound installation, rejecting the conventional radio schedules of presenters, programmes, music tracks, adverts etc. Its content is drawn from contributors within Dartmoor National Park, and includes oral histories, music, poems, field recordings, archive material and fragments of bespoke music. Skylark is also a public service and research project that intends to offer an innovative way forward for community radio in the UK. Such stations are intended to respond to their locations, include multiple voices, and be not-for-profit. …

Investigation Of Multiple Factors Influencing The Vector-Borne Transmission Of Salmonella Typhimurium Via Blattella Germanica, Landen Sean Van Hulzen

Dissertations and Theses

The German cockroach (Blattella germanica) is a common urban pest that lives ubiquitously in human structures around the world. German cockroaches are a severe public health threat as they are known carriers and vectors of human pathogens including Salmonella enterica, Escherichia coli, Shigella spp, and more. German cockroach infestations have been associated with Salmonellosis outbreaks. While mechanical transmission by the German cockroach vector is well known, new research suggests that more nuanced biological transmission has a role in maintaining and transmitting Salmonella enterica serovar Typhimurium (S. Typhimurium). Despite this recent finding, many biological variables influencing vector-borne transmission of S. Typhimurium …

Convergence In Cancer: Integrative Multi-Modal Modeling For Pan-Cancer Drug Response Prediction, Jessica Zylla

Dissertations and Theses

Heterogeneity and rarity can make cancer difficult to study and treat. Cancer's heterogeneity, evident in tumor locations, tumor cell types, subtypes, and microbiota within the tumor microenvironment, complicates diagnosis, prognosis, and treatment. Research into the tumor microenvironment and its microbiota is an evolving area of oncology that may advance cancer drug-patient response. Cancer-omics signatures are crucial to drug response, yet there is no tool that physicians use as a gold standard. Research indicates that microbial presence can alter drug metabolism and immune response, affecting cancer-drug efficacy on a patient-specific basis. This work highlights the need for training readiness in transdisciplinary …

An Exploration Of The Experiences And Factors Influencing Physical Activity In People With Parkinsons, Heather Hunter

School of Health Professions Theses

Abstract:Background: Physical activity plays a crucial role in enhancing the well-being and quality of life of people with Parkinsons. Despite substantial evidence supporting its benefits, people with Parkinson’s struggle to maintain an active lifestyle. This thesis explored the perspective of people with Parkinsons on their engagement in physical activity.Methodology: This research employed a person-centred approach, comprised of three sequential phases. Phase One: A systematic review utilising the JBI approach of meta-aggregation synthesised the best available qualitative evidence of people with Parkinson's' views and preferences regarding physical activity interventions. Phase Two: Constructive Grounded Theory was used to explore the beliefs, attitudes, …

Home-Based High-Intensity Interval Training For People With Parkinson’S : The Hiit-Home4parkinson’S Study, Conrad Harpham

School of Health Professions Theses

BackgroundExercise, particularly of high intensity, is considered to be important for people with Parkinson’s (PwP). However, PwP are less active than healthy individuals, and face disease specific and logistical barriers to exercise participation such as lack of outcome expectation, symptom exacerbation, travel logistics due to motor symptoms, expense and perceived lack of time. High-intensity interval training (HIIT) is a low volume exercise modality, evinced to be beneficial and time efficient for people within various healthy and clinical populations. HIIT therefore, particularly undertaken in the home could be apposite for PwP, although evidence is currently limited. Therefore, this study aimed to …

The Role Of Oral Nitrate Reducing Bacteria In Cardiovascular Health: Impacts Of Diet And Exercise, Craig Clarke

School of Health Professions Theses

This thesis investigated the important role of oral bacteria in blood pressure regulation and vascular function through the NO3--NO2--NO pathway following exercise or dietary interventions. Study 1 examined the effect of antibacterial mouthwash on the oral microbiome and nitrate metabolism in vegetarians and omnivores. Notable alterations in bacterial composition were observed after mouthwash administration, including reductions in the Prevotella genus (from 27.7% to 9.6%, P = 0.001) and Actinomyces genus (from 9.5% to 5.7%, P = 0.001), along with decreases in Prevotella melaninogenica (from 18.1% to 6.2%, P = 0.001) and Rothia dentocariosa (from 0.09% to 0.04%, P = 0.001). …

Factors Affecting Metabolism And Metabolic Control In Phenylketonuria, Alex Amorim Pinto

School of Health Professions Theses

Phenylketonuria (PKU) is an inherited metabolic disorder treated by a phenylalanine restricted diet in order to avoid neurocognitive impairment. Blood phenylalanine is the main outcome marker which is modulated by many dietary factors. Traditionally, L-amino acid-based protein substitutes are the main nitrogen source but more recently glycomacropeptide-based protein substitutes (GMP) have been introduced and are associated with several health benefits. The following aspects were studied in this thesis: 1) metabolic control achieved in patients with PKU compared with the European PKU guidelines; 2) life-long change in natural protein tolerance; 3) impact on metabolic control of different natural protein sources (animal …

Gender And The ‘Natural’ Environment In The Middle Ages, Edited By Theresa L. Tyers And Patricia Skinner, Danielle Allor

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Achieving Urban Resilience Strategies For Cities, Rehab Abdelfatah Abdel Aziz. Mahmoud

Mansoura Engineering Journal

The concept of the Resilient City is a relatively recent addition to urban planning discussions, gaining global attention due to the increasing need for cities to withstand urban, social, and environmental challenges. Urban resilience, alongside adaptability, plays a vital role in addressing these dynamic transformations. This research investigates how to implement urban resilience strategies to effectively respond to ongoing changes and sudden crises, such as terrorist attacks and natural disasters like floods, earthquakes, and hurricanes. The research identifies a critical gap in the absence of a comprehensive theoretical framework for evaluating the success of urban resilience strategies within cities’ planning …

Merging Biophilic Design Approach Into University Learning Interior Spaces: An Applied Experience, Sara M. Atwa

Mansoura Engineering Journal

Incorporating living elements into educational environments is a crucial matter, as many educational spaces are deprived of natural features. Designers should incubate this way of thinking to generate healthy and inspiring spaces for students. The biophilia hypothesis reveals that humankind has a genuine connection with the natural environment which makes us happier and healthier. Biophilic design has motivated architects to merge nature within the interior spaces using plants, reclaimed wood, water features, and daylight. Thereby, this manuscript debates that educational spaces – particularly in universities – requisite a sincere interaction with the nature environment by embracing biophilic design as an …

Catholic School Teaching As Participation In The Common Good, John L. Beltramo

Journal of Catholic Education

Increasing rates of teacher attrition have exacerbated the shortage of teachers in regions of the United States. In response, some scholars have proposed initiatives that promote the professionalization of teaching, hoping to attract and retain new teachers through greater classroom autonomy and stronger professional development. Others have advocated for a vision of teaching as a vocation, through which teachers can find deeper meaning and thereby better tolerate challenging working conditions. While both conceptualizations of teaching hold compelling implications for the field, their lack of grounding in a broader conception of community ultimately limit the extent to which they can respond …

Skinned Worlds: Virtual Reality And The Postbiological, Alicia Corts

Research, Publications & Creative Work

This paper explores the concept of “skinning” in educational virtual reality (VR) environments, reframing it as a dramaturgical and pedagogical act rather than a mere visual overlay. Through comparative analysis of The World of Hugo Simberg and C!ao: Piazza Navona Experience, the study investigates how design decisions shape user identity, agency, and the performance of learning. Drawing on performance theory, it examines how avatars – or their absence – guide learners through curated paths, subtly influencing perception and interaction. While both applications strip away overt self-representation, they open space for subversion, reflection, and imaginative engagement. The paper argues that skinning …

A Computational Fluid Dynamics (Cfd) Based Assessment Of Animal Borne Data Logger Impact, Christopher Pass

School of Engineering, Computing and Mathematics Theses

Animal borne data loggers are powerful tools that provide researchers with valuable insight into the behaviour and ecology of free-ranging marine animals. Despite their usefulness, the addition of a tag inevitably alters the forces acting on a swimming body and can increase the energetic cost of swimming. Computational Fluid Dynamics (CFD) tools offer a powerful means of assessing tag impact and a number of previous works have employed CFD to this end but have typically been based on a range of simplifying assumptions. Chief amongst these simplifications is that animals can be modelled as rigid bodies with a simple tag …

Upregulation Of Delta Opioid Receptor By Meningeal Interleukin-10 Prevents Relapsing Pain, Kufreobong E Inyang, Jaewon Sim, Kimberly B Clark, Matan Geron, Karli Monahan, Christine Evans, Patrick O'Connell, Sophie Laumet, Bo Peng, Jiacheng Ma, Cobi J Heijnen, Robert Dantzer, Grégory Scherrer, Annemieke Kavelaars, Matthew Bernard, Yasser A Aldhamen, Joseph K Folger, Alexis Bavencoffe, Geoffroy Laumet

Faculty, Staff and Student Publications

Chronic pain often includes periods of transient amelioration and even remission that alternate with severe relapsing pain. While most research on chronic pain has focused on pain development and maintenance, there is a critical unmet need to better understand the mechanisms that underlie pain remission and relapse. We found that interleukin (IL)-10, a pain resolving cytokine, is produced by resident macrophages in the spinal meninges during remission from pain and signaled to IL-10 receptor-expressing sensory neurons. Using unbiased RNA-sequencing, we identified that IL-10 upregulated expression and antinociceptive activity of δ-opioid receptor (δOR) in the dorsal root ganglion. Genetic or pharmacological …

Oral Microbiome Brain Axis And Cognitive Performance In Older Adults, Darbaz Adnan, Phillip A Engen, Michelle Villanueva, Shohreh Raeisi, Vivian Ramirez, Ankur Naqib, Stefan J Green, Faraz Bishehsari, Lisa L Barnes, Ali Keshavarzian, Klodian Dhana, Robin M Voigt

Faculty, Staff and Student Publications

The human oral microbiota is a community of microorganisms that reside in the oral cavity, including lingual, buccal, and saliva, each niche with a distinct microbial composition. Alterations in oral microbiota have been associated with an increased risk of Alzheimer’s disease (AD). This study used data from 143 older adults in the MIND trial to evaluate the association between oral microbiome and cognitive function. Oral niche-specific differences (saliva, buccal, and lingual), as well as the microbiome composition differences (α and β diversity), were associated with cognitive function. A lower abundance of Gemella and a higher abundance of anaerobic pro-inflammatory bacteria …

Use Of Hookah And Age Of Asthma Onset Among Us Adults, Adriana Pérez, Sarah Valencia, Pushan P Jani, Melissa B Harrell

Faculty, Staff and Student Publications

Objective: To explore the association of hookah use on the age of asthma onset among adults who were asthma/COPD free and who did not use cigarettes, cigars, electronic cigarettes or smokeless tobacco prior to asthma onset.

Methods: Secondary data analyses were conducted of the waves 1-6 (2013-2021) of the US nationally representative Population Assessment of Tobacco and Health Study among adults (>18 years). The four hookahs use exposures evaluated were (1) past 30-day (P30D) hookah use at the first wave of participation, (2) total number of waves before asthma onset in which adults reported P30D hookah use, (3) total …

Esomeprazole Inhibits Proliferation Of Scleroderma Fibroblasts Via Cell Cycle Regulation, Mohammad A Khan, Shaheer Koniyan, Manisha Ahir, Anil G Jegga, Maureen D Mayes, David Gius, Justin Leung, Mark D Bonnen, Sydney B Montesi, Yohannes T Ghebre

Faculty, Staff and Student Publications

Background: Scleroderma is a complex autoimmune disease characterized by abnormal fibroblast proliferation and excessive collagen deposits in the skin and internal organs. We previously showed that esomeprazole, an FDA-approved drug for gastric disorders, may prevent dermal fibrosis.

Methods: To test this, we evaluated the antiproliferative effect of esomeprazole and the underlying molecular mechanisms using primary fibroblasts derived from patients with scleroderma. BrdU incorporation, flow cytometry, immunofluorescence, Western blot analysis, RNA sequencing, and functional enrichment analysis were performed.

Results: Esomeprazole inhibited the proliferation of scleroderma fibroblasts in a dose-dependent manner, as measured by BrdU incorporation and Ki-67 marker. Intriguingly, esomeprazole arrested …

Long-Term Dynamic Profiles Of Cognitive Kinases Induced By Different Learning Protocols, Yili Zhang, Rong-Yu Liu, Paul Smolen, John H Byrne

Faculty, Staff and Student Publications

Learning is associated with activation of multiple protein kinases, but few details are known about the activation dynamics in response to different learning protocols. We addressed this issue by examining the long-term dynamics of kinases critical for long term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse. Three serotonin (5-HT) protocols have been found to induce LTF with distinct effectiveness: the five-pulse regular-spaced Standard protocol; the five-pulse irregular-spaced Enhanced protocol; and the two-pulse protocol with an interval of 45 min. We previously compared long-term dynamics of the mitogen-activated protein kinase (MAPK) isoform ERK after these protocols. Here we examined the …

Neutrophils Unveiled In Chronic Lymphocytic Leukemia, Sheighlah Mcmanus, Priyanka Khare, Maria Teresa S Bertilaccio

Faculty, Staff and Student Publications

This review explores neutrophils' roles in chronic lymphocytic leukemia (CLL), highlighting their functions within the immune system. While neutrophils are known for fighting infections, their altered behavior in CLL significantly impacts disease progression. This review notes the reduced phagocytic abilities of neutrophils and the increased formation of neutrophil extracellular traps (NETs) in patients with CLL. It also examines the effects of CLL treatments, including chemotherapy, immunotherapy and targeted therapies, on neutrophils' count and function, stressing the need for improved strategies to manage therapy-induced immune dysfunction. This review also provides detailed information about the interactions between neutrophils and other immune elements …

Protecting Organs-At-Risk In Cancer Therapies Through Temporary Organ Displacement: A Comprehensive Review, Rance B Tino, Michael Li, Amirreza Heshmat, Ayush Suresh, Anasimone Guillaume, Kristy K Brock, Bruno C Odisio, Eugene J Koay

Faculty, Staff and Student Publications

Radiation therapy (RT) and locoregional ablation are cornerstones of modern oncology, yet their therapeutic potential is frequently limited by the challenge of sparing healthy organs-at-risk (OARs) from treatment-related complications. Temporary organ displacement (TOD) techniques directly address this issue by creating a physical separation using 'spacers' during treatment, thereby minimizing collateral damage while enhancing therapeutic precision. The clinical benefits, including improved tumor control, reduced morbidity, and enhanced survival, are documented across malignancies of the head and neck, thorax, abdomen, and pelvis. To create a unified framework for this evolving field, this comprehensive review provides a systematic classification of TOD techniques based …

Nutritional Management Of The Child With Chronic Kidney Disease And On Dialysis., Vanessa Shaw, Caroline Anderson, An Desloovere, Larry A. Greenbaum, Lyndsay Harshman, Christina L. Nelms, Pearl Pugh, Nonnie Polderman, José Renken-Terhaerdt, Evelien Snauwaert, Stella Stabouli, Jetta Tuokkola, Johan Vande Walle, Bradley A. Warady, Fabio Paglialonga, Rukshana Shroff

Manuscripts, Articles, Book Chapters and Other Papers

While it is widely accepted that the nutritional management of the infant with chronic kidney disease (CKD) is paramount to achieve normal growth and development, nutritional management is also of importance beyond 1 year of age, particularly in toddlers, to support the delayed infantile stage of growth that may extend to 2-3 years of age. Puberty is also a vulnerable period when nutritional needs are higher to support the expected growth spurt. Inadequate nutritional intake throughout childhood can result in failure to achieve full adult height potential, and there is an increased risk for abnormal neurodevelopment. Conversely, the rising prevalence …

Digital Twins In Healthcare: A Comprehensive Review And Future Directions, Hamid Khoshfekr Rudsari, Becky Tseng, Hongxu Zhu, Lulu Song, Chunhui Gu, Abhishikta Roy, Ehsan Irajizad, Joseph Butner, James Long, Kim-Anh Do

Faculty, Staff and Student Publications

Digital Twin (DT) technology has emerged as a transformative force in healthcare, offering unprecedented opportunities for personalized medicine, treatment optimization, and disease prevention. This comprehensive review examines the current state of DTs in healthcare, analyzing their implementation across different physiological levels-from cellular to whole-body systems. We systematically review the latest developments, methodologies, and applications while identifying challenges and opportunities. Our analysis encompasses technical frameworks for cardiovascular, neurological, respiratory, metabolic, hepatic, oncological, and cellular DTs, highlighting significant achievements such as population-scale cardiac modeling (3,461 patient cohort), reduced atrial fibrillation recurrence rates through patient-specific cardiac models, improved brain tumor radiotherapy planning, advanced …

Role Of Mir-204 In Controlling Metabolic Functions Of The Subretinal Microglia, Yan Chen, Sarah E Bounds, Neloy Kundu, James Regun Karmoker, Yin Liu, Dongin Kim, Jiyang Cai

Faculty, Staff and Student Publications

Rationale: MicroRNA-204 (miR-204) is one of the most abundant miRNA species in the retinal pigment epithelium (RPE) and RPE-derived extracellular vesicles (EVs). Knockout (KO) of miR-204 leads to dysfunction and degeneration of both the RPE and the retina. In addition to previously reported retinal pathologies, we observed the accumulation of lipid-laden subretinal microglia in miR-204 KO mice. This study aimed to identify potential molecular targets of miR-204 involved in microglia lipid processing and to determine whether RPE-derived EVs can improve the function of miR-204-deficient retinal microglia.

Methods: Lipid accumulation in microglia was detected by staining with LipidTox, a fluorescent dye …

Combined Inhibition Of Lysine-Specific Demethylase 1 And Kinase Signaling As A Preclinical Treatment Strategy In Glioblastoma, Lea M Stitzlein, Deokhwa Nam, Faith A Hernandez, Kareena H Patel, Alaina Poche, Huaxian Ma, Katie Impelman, Joy Gumin, Heping Wang, Jing Wang, Samantha Gadd, Wafik Zaky, Oren Becher, Richard W Dudley, Frederick F Lang, Gangadhara R Sareddy, Joya Chandra

Faculty, Staff and Student Publications

Background: Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma, contributing to tumor growth and treatment resistance. LSD1 inhibitors have shown preclinical promise but have had limited clinical development for glioblastoma. Given the frequent kinase pathway alterations seen in glioblastoma, the interplay between LSD1 inhibition and kinase signaling pathways was investigated.

Methods: Glioblastoma stem cell (GSC) lines and normal human astrocytes (NHAs) were treated with catalytic LSD1 inhibitors, NCD38 and bomedemstat, and the LSD1 scaffolding inhibitor, seclidemstat alone and in combination with kinase inhibitors, including osimertinib, afatinib, and ulixertinib. The effect on cell viability, proliferation, and neurosphere formation was assessed, and …

Histopathologic Progression And Metastatic Relapse Outcomes In Small Cell Neuroendocrine Carcinomas Of The Urinary Tract, Mohammad Jad Moussa, Georges C Tabet, Arlene O Siefker-Radtke, Lianchun Xiao, Nathaniel R Wilson, Jianjun Gao, Christopher J Logothetis, Petros Grivas, Byron Lee, Amishi Y Shah, Pavlos Msaouel, Roger Li, Leticia Campos Clemente, Jianping Zhao, Nizar M Tannir, Ashish M Kamat, Donna E Hansel, Charles C Guo, Matthew T Campbell, Omar Alhalabi

Faculty, Staff and Student Publications

Introduction: Small cell neuroendocrine carcinoma of the urinary tract (SCNEC-URO) has an inferior prognosis compared to conventional urothelial carcinoma (UC). Here, we evaluate the predictors and patterns of relapse after surgery.

Materials and methods: We identified a definitive-surgery cohort (n = 224) from an institutional database of patients with cT1-T4NxM0 SCNEC-URO treated in 1985-2021. Histopathologic review was conducted by independent pathologists. Relapse event was the time-to-event outcome, and relapse probabilities were estimated using a competing risk method with cumulative incidence functions (CIFs). Fine-Gray distribution models assessed covariate associations.

Results: Most patients (161, 71.9%) received neoadjuvant chemotherapy (neoCTX). Ninety two (41%) …

Relationship Between Trpm4 Rs8104571 Genotype, Circulating Trpm4 And Sur1, And Clinical Outcome Following Traumatic Brain Injury, Joseph D Krocker, Madeline E Cotton, Janet R Ashley, Jacob B Schriner, Baron K Osborn, Yao-Wei Willa Wang, Charles S Cox, Charles E Wade

Faculty, Staff and Student Publications

The variant single nucleotide polymorphism rs8104571 has been associated with poor outcomes following traumatic brain injury (TBI) and is most prevalent in those of African ancestry. This single nucleotide polymorphism (SNP) resides within a gene coding for the TRPM4 protein, which complexes with SUR1 protein to create a transmembrane ion channel and is believed to contribute to cellular swelling and cell death in neurological tissue. Our study evaluates the relationship between circulating TRPM4 and SUR1, rs8104571 genotype, and clinical outcome in TBI patients. Trauma patients with moderate to severe TBI were included in this retrospective study. rs8104571 genotyping and admission …