Digital Commons Network^™

Jack West, Jack West, Stephanie Mladinich

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Differentially Expressed Mirnas Explain Racial Differences In Diagnosis Stage Among Triple Negative Breast Cancer Patients In Louisiana, Yawen Hu, Xioacheng Wu, Meng Luo, Nubaira Rizvi, Amjila Bam, Luis Del Valle, Lucio Miele, Qingzhao Yu

Journal of the Louisiana Public Health Association

Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype that disproportionately affects African American (AA) women, leading to worse survival rates and higher metastasis risks compared to Caucasian American (CA) women. MicroRNAs (miRNAs) are crucial in cancer development and hold promise as biomarkers, but their role in racial disparities in TNBC outcomes is unclear. Methods: This study used Louisiana Tumor Registry data and collected tumor tissues for miRNA sequencing to examine significant miRNAs differentially expressed by race and TNBC stages at diagnosis among 3,298 TNBC cases diagnosed from 2011 to 2017. Results: Of the TNBC cases, 49.7% were AA. …

The Prospector, November 21, 2025, Utep Student Publications

The Prospector

No abstract provided.

Design And Validation Of A Bilateral, Multi-Site 3d-Printed Neuronal Implant For Rodent Electrophysiology, Homero Phelps, Jonathan V. Trinidad, Talha Soluoku

Undergraduate Research Symposium Podium Presentations

Neuronal electrophysiology implants are essential tools in neuroscience for recording brain activity and investigating neurological disorders. Our lab’s previous 3D-printed implant designs centered around a single-site, recording platform that was limited in adaptability, precision, and lacked in vivo validation due to lingering engineering malfunctions. To combat limitations and expand recording capabilities, this project aimed to design and validate a new implant capable of multi-site, bilateral recordings across both brain hemispheres, specifically targeting the hippocampus (CA1 and CA3) and anterior cingulate cortex (ACC), regions critical for learning and memory. Building on the Open Ephys ShuttleDrive model, the implant was redesigned using …

Dorsal/Ventral Orientation Of Dentate Granule Cells And Its Impact On Electrophysiology In Mice, Jacob Prince, Savannah Sampson, Alyssa Marron

Undergraduate Research Symposium Posters

The hippocampus has known roles in memory formation, learning, and spatial mapping. There are defined physiological differences between CA1 neurons based on their dorsal to ventral position within the 3D hippocampus (Malik et al., 2015). Given the varying functions of the dorsal and ventral hippocampus in cognitive processing and the role of the dentate gyrus as the entry point for information into the hippocampus, it will be interesting to determine if there are differences in the properties of granule cells across the dorsal and ventral axis. We explore the potential topographic specialization of dentate granule cells. This study examines the …

Mpox Insights: From Structure To Human Cell Interaction, Md. S. Zaman, Robert C. Sizemore, Draven Rodriguez, Emilio Lopez, S. M. Golam Alam, Suleyman Tufa, Juan C Lopez Alvarenga, Nuraly S. Akimbekov, Mohammed S. Razzaque

School of Medicine Publications

Mpox, a zoonotic viral disease, has emerged as a global concern due to outbreaks in both endemic and non-endemic regions in 2022. Rodents, including African squirrels and Gambian pouched rats, are suspected key reservoirs, with human infections occurring through direct contact with infected animals or bushmeat consumption. Previously confined to rural Africa, mpox has spread via international travel and the exotic pet trade. Human-to-human transmission occurs mainly via respiratory droplets and direct contact with bodily fluids or lesions. The virus has a double-stranded DNA genome within a lipid envelope. Despite lower mutation rates in DNA viruses, mpox has developed mutations, …

Patent Monopsonies, Roy Baharad, Gideon Parchomovsky

Duke Law Journal

Conventional wisdom perceives patent protection as a necessary evil. Patent protection, the argument goes, raises the prices of patented products and processes, thus restricting access to innovation. But without it, not enough innovation will be produced. Hence, generations of scholars have sought ways to curb the market power of patentees via various legal interventions, such as prizes, compulsory licenses, and other forms of regulation. All have tacitly assumed that eroding the market power of patentees would result in a competitive market for innovation that would put an end to the allocative inefficiencies and distributional inequities that emanate from patent protection. …

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …

Exploring The Interplay Between Hypertension And Osteoporosis: A Narrative Review, Yolanda V. Gutierrez, Ronald Shaju, Alyssa A. Sepulveda, Seval Coban

School of Medicine Publications

Hypertension and osteoporosis are highly prevalent chronic conditions that have significant implications for global health, especially in aging populations. While these conditions have traditionally been viewed as separate, emerging research suggests a strong pathophysiological link between the two. Understanding these shared mechanisms may help improve screening and guide integrated management strategies. This narrative review was conducted between January 2024 and July 2025 using PubMed, ScienceDirect, and Google Scholar. The search strategy used the Boolean string: (“hypertension” OR “high blood pressure”) AND (“osteoporosis” OR “bone loss”), supplemented with pharmacologic terms (“ACE inhibitors,” “angiotensin receptor blockers,” “thiazide diuretics,” “beta-blockers”, “SERMS”, “Bisphosphonates”, “Denosumab”, …

Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …

A Triple Bottom Line Analysis Of Food Waste-To-Bioenergy At California University Campuses: Social Enablers Break Down Economic Barriers, Anjali Sharma

Master's Theses

Greenhouse gas emissions from food waste (FW) and energy generation are two major hurdles to the climate crisis. Previous research shows that waste-to-energy systems may provide a solution to both these challenges, particularly at university campuses, due to their high FW generation and high energy needs. Despite this, few academic institutions in California, US, have adopted waste-to-energy systems, and campus-specific challenges and opportunities associated with these systems remain underexplored. For this study, I use an Environmental, Economic, and Social (EES) lens to document the current landscape of FW management and implementation of food waste-to-bioenergy at campuses in each of the …

Examining Microbial Biomass And Soil Organic Carbon In Annual Vs. Perennial Agricultural Ecosystem Soils, Paige Kenyon, Jacob Rutz, Kelsey S. Bitting

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Soil systems have the ability to store large amounts of carbon for both short and long periods of time, much like other carbon pools such as oceans and forests. As increased amounts of carbon dioxide are released into the atmosphere via anthropogenic means, including the agricultural industry, scientists have been researching how to increase the amount of carbon cycled from the atmosphere and into soils as a climate change mitigation strategy. Soil systems have the capacity to sequester carbon in part due to fungal and bacterial community activity. Differences in soil microbial biomass levels between annual and perennial agricultural systems …

Re-Membering Self, Rewriting Histories, Reclaiming Futures: Chicanafuturist Agency In V. Castro's The Haunting Of Alejandra, Julia Reade

Regeneración: A Xicanacimiento Studies Journal

Re-membering Self, Rewriting Histories, Reclaiming Futures: Chicanafuturist Agency in V. Castro's The Haunting of Alejandra by Julia Reade.

Deaf Parents’ Infant-Directed Touch With Their Hearing And Deaf Babies: Intuitive, Cultural, Or In Need Of Instruction?, Brenda C. Seal Ph.D.

Journal of Early Hearing Detection and Intervention

No abstract provided.

First Report Of A Bat Guano Fire From A Cave In Southeast Asia, Sopark Jantarit, Martin Ellis, Pruet Kalasuwan, Neeranuch Phusunti, Pimonsri Mittraparp-Arthorn, Jiranan Pattano, Arnon Chukamnerd, Turdtun Tong-In, Natthawut Khrueaaunruean

International Journal of Speleology

Fires occurring in cave guano are a rare and unusual phenomenon and the occurrence of such events in Southeast Asia is particularly novel. In this study, we document the first recorded instance of a bat guano fire in a tropical cave at Tham Chao Ram in Sukhothai province, northern Thailand. A bacteriological analysis was made of the guano at the fire site and from a control site within the cave. We give a comprehensive review of global reports on bat guano fires in caves, conduct an initial investigation of the physical factors at the fire site and discuss the potential …

Guardrail Design And Placement 101, Katherine Smutzer

Civil Engineering Professional Development Seminar

Not all “guardrail” is created equal. Within the last 10 years INDOT has adopted the MASH-compliant Midwest Guardrail System (MGS). While similar to the previous standard w-beam guardrail, there are nuances that aren’t well understood by designers. The presentation would reinforce the fundamentals of guardrail as a safety barrier, explain the function of various components of a guardrail system, and review important design considerations.

Zika Virus: A Review Of An Emerging Disease Threatening Global Health, Gudikandula Krishna, S. Sreedevi, Dasari Thrimothi

Maaen Journal for Medical Sciences

The Zika virus (ZIKV) has caused a widespread pandemic that is currently spreading throughout Central America, the United States of America, South America, and the Caribbean. The goal of the review is to provide a detailed summary of relevant information to the readers that is currently available about the genetic structure of the Zika virus, transmission, pathogenesis, clinical manifestations, complications, treatment, diagnosis, and genetic composition of Zika virus infection. The relevant literature on ZIKV was retrieved by employing Science Direct, Google Scholar, PubMed, Science Direct Index, electronic databases. The analysis concludes that the Zika virus (ZIKV) primarily spreads among arboreal …

Molecular Analyses Of Cellulosimicrobium Cellulans Mosul Isolated From Crown Galls Of Olea Europaea, Ghazwan Qasim Hasan

Karbala International Journal of Modern Science

Olea europaea L. is farmed extensively for its oil in various parts of the world. Olives are abundant in bioactives and beneficial minerals that may have therapeutic and medicinal applications. Cellulosimicrobium cellulans belongs to the family Promicromonosporaceae and is classified as a Gram-positive bacillus. Since there is not much research on the topic, the goal of the current study was to analyze the whole genome sequence of this bacterium. The results showed that 99.8% of the raw values agreed well with the reference strain CP017660, with a GC content of 74.5% and a pairwise similarity of 98.1%. The de …

Enhancing Recommendation Performance Via Stacking Ensemble And Synthetic Data Augmentation, Zahraa Yaareb Hani, Mohsin Hasan Hussein

Karbala International Journal of Modern Science

Recommendation systems are essential tools that primarily aim to help users navigate through a large volume of information. They simplify the decision-making process by suggesting relevant items based on users’ historical behaviour. However, their performance is often affected by common problems such as data sparsity. This work proposes a stacking-based ensemble recommendation system that integrates multiple machine learning models to enhance the model’s predictive performance. A new synthetic data augmentation technique is introduced to address the sparsity issue in the user–item rating matrix. This method uses the Naïve Bayes algorithm to predict additional ratings for each user. These are then …

Novel Eco-Friendly Synthesis Of Coo Nps: Evaluation Of Their Diode Laser-Enhanced Inhibitory Activity Through Combined In Silico And In Vitro Approaches., Arshad Mahdi Hamad, Sahar Naji Rashid

Karbala International Journal of Modern Science

In our study, for the first time worldwide, to the best of our knowledge, cobalt oxide nanoparticles (CoO NPs) were synthesized using naringin (Nar) extracted from citrus peels. The properties of the prepared Nar-CoO NPs were studied using field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), ultraviolet-visible (UV-Vis), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. All the test results demonstrated the efficiency and success of the nanofabrication process. The solution was then exposed to three types of diode lasers: red (650 nm), green (532 nm), and blue (405 nm). The purpose of this study was …

Gdf15 Is A Putative Biomarker For Distinguishing Pulmonary Veno-Occlusive Disease And Pulmonary Arterial Hypertension, Amit Prabhakar, Eckart De Bie, Jacqueline T. Desjardin, Prajakta Ghatpande, Stefan Gräf, Luke S. Howard, S. John Wort, Colin Church, David G. Kiely, Uk Pulmonary Arterial Hypertension Cohort Study Consortium, Emily Sumpena, Thin Aung, Shenrae Carter, Jasleen Kukreja, Steven Hays, John R. Greenland, Jonathan P. Singer, Michael Wax, Paul J. Wolters, Marc A. Simon, Mark Toshner, Giorgio Lagna, Akiko Hata

Biology

To the Editor: Pulmonary veno-occlusive disease (PVOD) is a rare, severe group 1 pulmonary arterial hypertension (PAH) subtype with poor survival (1). PAH-targeted vasodilators can cause life-threatening pulmonary edema in PVOD, underscoring the need for diagnostic tools to distinguish it from other PAH subtypes (1). In patients and mitomycin C–induced (MMC-induced) model animals, aberrant activation of integrated stress response (ISR) via protein kinase R (PKR) drives cardiovascular phenotypes of PVOD (2–4). Inhibition of the PKR-ISR axis, using either the PKR inhibitor C16 or the ISR inhibitor ISRIB, reverses PVOD phenotypes (2–4). Because GDF15 is a cytokine induced by the ISR …

Mahi Mahi (Coryphaena Hippurus) Neurocranium, Ameer Tolani, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Spectator 2025-11-20, Editors Of The Spectator

The Spectator

No abstract provided.

Place, History, And Memory: New York City’S World’S Fairs In Flushing Meadows-Corona Park, Peter Conolly-Smith

Open Educational Resources

This proposal for an intermediate-level History seminar taps into students’ memory, sense of place, and history skills by focusing on a space many of them already know: Flushing Meadows-Corona Park. From its origins as wetlands converted in the early twentieth century to a dumping ground for ashes memorialized in F. Scott Fitzgerald’s The Great Gatsby and on to its later incarnation as the site of the 1939 and 1964 World’s Fairs, the park’s history and those of the two fairs—richly documented, all—provide ample material for a place-based seminar that utilizes multiple aspects of experiential learning.

While all the reading and …

The Comment, November 20, 2025, Bridgewater State University

The Comment

No abstract provided.

Mark Robertson, Mark Robertson, Esther Hewitt

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Chris Chavez, Chris Chavez

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Evaluation Of Nine Sh2 Sweet Corn Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A bicolor sh2 sweet corn cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). Seeds were donated by Crookham (CK), and Rupp (RP) seed companies. Two synergistic varieties were donated by Chris Difonzo from the Bt resistance project and were treated as unsprayed late-season checks against caterpillar infestation. Overall trial conditions were hot and dry, with moisture stress throughout the trial on a sandy hill. Overhead irrigation provided some relief. A new seeder was used that planted at a lower population than desired. As such, yield suffered in this trial.

The Colby Echo (2025-11-20), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

Place, Space, And Landscape: Discovering Queens Through Community Music And Performing Arts, Claudia Calì

Open Educational Resources

Place, Space, and Landscape: Discovering Queens through Community Music and Performing Arts is a graduate-level course designed to explore how music, dance, and theater can engage, reflect, and transform local communities through a critical pedagogy of place (Gruenewald, 2003) and service-learning experiences (Mitchell, 2008).

Intended for graduate students in music, visual, and performing arts, this interdisciplinary course blends theory and practice to help students: (1) gain awareness of the spatial dimensions of their artistic experience; (2) build meaningful connections and relationships of care with local communities; and (3) engage with the concept of reinhabitation (Gruenewald, 2003), situating learning within specific …