Digital Commons Network^™

Land, Labor, Legacy: Historic Family Farms In Licking County Journalistic Analysis Of Rural Heritage Through Historic Family Farms, Delaney Susan Brown

Student Scholarship

No abstract provided.

Reproducibility And Repeatability Of 18f-(2s, 4r)-4-Fluoroglutamine Pet Imaging In Preclinical Oncology Models, Gregory D Ayers, Allison S Cohen, Seong-Woo Bae, Xiaoxia Wen, Alyssa Pollard, Shilpa Sharma, Trey Claus, Adria Payne, Ling Geng, Ping Zhao, Mohammed Noor Tantawy, Seth T Gammon, H Charles Manning

Faculty, Staff and Student Publications

Introduction: Measurement of repeatability and reproducibility (R&R) is necessary to realize the full potential of positron emission tomography (PET). Several studies have evaluated the reproducibility of PET using 18F-FDG, the most common PET tracer used in oncology, but similar studies using other PET tracers are scarce. Even fewer assess agreement and R&R with statistical methods designed explicitly for the task. 18F-(2S, 4R)-4-fluoro-glutamine (18F-Gln) is a PET tracer designed for imaging glutamine uptake and metabolism. This study illustrates high reproducibility and repeatability with 18F-Gln for in vivo research.

Methods: Twenty mice bearing colorectal cancer cell line xenografts were injected with ~9 …

Selective Inhibition Of Canonical Stat3 Signaling Suppresses K-Ras Mutant Lung Tumorigenesis And Reinvigorates Anti-Tumor Immunity, Michael J Clowers, Zahraa Rahal, Sung-Nam Cho, Avantika Krishna, Bo Yuan, Leticia G Hamana Zorrilla, T Kris Eckols, Moses M Kasembeli, Samuel Liu, Stephen Peng, Marco Ramos-Castaneda, Annamarie L Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E Larsen, Maria T Grimaldo, Shanshan Deng, Nastaran Karimi, Cody Chou, Walter V Velasco, Melody Zarghooni, Sayan Alekseev, Luisa M Solis Soto, Edwin J Ostrin, Humam Kadara, Suhendan Ekmekcioglu, David J Tweardy, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

Introduction: K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. One of the lynchpins of chronic inflammation in KM-LUAD is signal transducer and activator of transcription 3 (STAT3).

Methods: Here, we tested the anti-tumor and early immunotherapeutic efficacy of TTI-101, a selective small-molecule inhibitor of canonical STAT3 signaling, in a K-rasG12D mutant lung cancer mouse model (CC-LR).

Results: Treatment of CC-LR mice with TTI-101 resulted in reduced …

Inhibition Of Nitric Oxide Synthase Transforms Carotid Occlusion-Mediated Benign Oligemia Into De Novo Large Cerebral Infarction, Ha Kim, Jinyong Chung, Jeong Wook Kang, Dawid Schellingerhout, Soo Ji Lee, Hee Jeong Jang, Inyeong Park, Taesu Kim, Dong-Seok Gwak, Ji Sung Lee, Sung-Ha Hong, Kang-Hoon Je, Hee-Joon Bae, Joohon Sung, Eng H Lo, James Faber, Cenk Ayata, Dong-Eog Kim

Faculty, Staff and Student Publications

No abstract provided.

The Ethical Theory Of Enrique Dussel: An Investigation Of Violence And Coercion In His Three Foundational Principles, Eric Antonio Del Valle Cruz

Dissertations

Problem

Enrique Dussel's ethics proposes addressing global inequality through legitimate coercion as a means of liberating the poor, contrasting it with the violence of the current system. However, the inclusion of life-threatening acts, such as armed revolution, as coercion raises practical challenges for the Christian community, including ethical-political dialogue, inclusion of opposing parties, and potential dehumanization, which need further exploration in light of Dussel’s use of Scripture in support of his proposals.

Purpose

This dissertation aims to assess Dussel's philosophical principles and their connection to coercion and violence, ultimately establishing a framework for a conservative Christian proposal that combines the …

Quantifying Biodiversity In The Absence Of Taxonomic Data: A Study Of Thailand’S Economic Development Zones, Nikorn Mahawan, Wanpen Charoentrakulpeeti

Applied Environmental Research

The biodiversity status measures the ecological capacity of a given area. However, biodiversity assessments in developing countries are limited by the absence of taxonomic data on plants and animals. By developing methods to evaluate biodiversity via alternative data, it is now possible to quantify the ecological carrying capacity in areas where taxonomic data are lacking. The relationship between forest ecosystem health and biodiversity values can be used to estimate biodiversity values by considering the proportions of different land use types that are associated with forest ecosystem abundance. The biodiversity value of the area can be assessed by adding the abundance …

Using A Water Quality Index To Assess The Impacts Of Heavy Metals Contamination For Sustainable Water Management: A Case Study Of The Bang Pakong River, Thailand, Khin Yadana Soe, Pokchat Chutivisut, Wilailuk Niyommaneerat

Applied Environmental Research

Anthropogenic activities such as improper waste disposal, excessive fertilizer use, and industrial effluents cause heavy metal contamination in water, soil, and the atmosphere. Herein, the water quality index (WQI) was used to characterize heavy metal (i.e., cadmium (Cd), arsenic (As), and mercury (Hg)) contamination in the Bang Pakong River, Thailand. Specifically, water samples were collected during the dry season from four stations along the river from 2012–2022. The heavy metal concentrations in the samples were analyzed via atomic absorption spectrophotometry, and WQI values were calculated on the basis of standard water quality parameters. At the four sampling stations, high As …

Halotolerant Biodegradation And Detoxification Of Synthetic Dyes By Marine-Derived Penicillium Oxalicum M6a: Metabolite Profiling And Ecotoxicity Assessment, Ugochukwu Okechukwu Ozojiofor, Mohammed Sani Abdulsalami, Nkechi Eucharia Egbe, Ahmed Ali Haroun, Yakubu Magaji

Applied Environmental Research

The complex aromatic structures of synthetic dyes in contaminated water bodies make them difficult to degrade, posing a serious environmental challenge and representing a significant emerging pollutant that warrants urgent intervention. This study evaluated the biodegradation and detoxification potential of a halotolerant, marine-derived fungal strain, Penicillium oxalicum M6A, isolated from the Nigerian coastline, against Indigo carmine (IC) and Remazol Brilliant Blue R (RBBR). The effects of pH, temperature, salinity, and dye concentration on degradation efficiency, alongside enzymatic activity, were assessed. FTIR and GC‒MS analyses were employed to identify degradation products and predict metabolic pathways, whereas toxicity was evaluated in three …

Investigating Spatial And Temporal Changes In Vegetation Via Remote Sensing Indicators And Revealing Their Trends In The Central Desert Of Iran, Peyman Akbarzadeh, Shima Nikoo, Mehran Akbarzadeh

Applied Environmental Research

Vegetation changes can significantly affect the conditions and productivity of ecosystems. Consequently, studying vegetation dynamics across various temporal and spatial scales has emerged as a critical environmental concern. The aim of this study was to investigate changes in vegetation cover via vegetation indices, including the normalized difference vegetation index (NDVI), ratio vegetation index (RVI), soil adjusted vegetation index (SAVI), and difference vegetation index (DVI), derived from multitemporal Landsat 5, 7, and 8 satellite images processed via the Google Earth Engine. The study area is located in the Damghan arid and desert watershed, which represents the central desert of Iran. Furthermore, …

Assessment Of The Carbon Stock Of Trees In Selected Urban Green Spaces Of Davao City, Philippines, Daiseree Cuabo, Yves P.M. Montero, Daryl S. Salas, John P.M. Viernes

Applied Environmental Research

The combined impacts of deforestation, tree cover loss, and urbanization in urban and suburban areas significantly reduce the capacity of natural carbon sinks to sequester and store carbon. Hence, this study assessed the aboveground biomass (AGB) and carbon stock of trees in the selected green spaces of Davao City. A purposive sampling technique was employed in placing quadrats, with data collected from 27 plots categorized by size. AGB was estimated via an allometric equation, and aboveground carbon (AGC) was derived from the AGB values. A total of 358 individual trees from 25 species, 24 genera, and 13 families were documented. …

Spatial And Temporal Trends In Surface Water Quality And Pollution Sources In Ben Tre, Vietnam: A Principal Component Analysis/Factor Analysis-Based Approach, Nguyen Xuan Tong, Luu Tang Phuc Khang

Applied Environmental Research

Surface water quality is vital for maintaining ecological health and supporting sustainable development, particularly in the Mekong Delta, Vietnam, where water is heavily utilized. However, rapid urbanization and economic activities have led to water pollution. This study assessed the spatial and temporal variations in surface water quality in Ben Tre Province from January 2022 to December 2023 using 384 samples collected across dry and rainy seasons and two zones (headwater streams and cities). The water quality index (WQI) was calculated on the basis of 15 parameters, and principal component analysis/factor analysis was applied to identify pollution sources. Five key factors …

Development Of Highly Effective Sulfonic Acid–Functionalized Nr/Ms Nanocomposites For Biodiesel Production, Sakdinun Nuntang, Satit Yousatit, Toshiyuki Yokoi, Chawalit Ngamcharussrivichai

Applied Environmental Research

The acidic natural rubber/wormhole-like mesostructured silica nanocomposites (NR/WMS-SO3H) were successfully functionalized with propylsulfonic acid and arenesulfonic acid via a cocondensation method using 3-mercaptopropyl trimetho-xysilane (MPTMS) and 2-(4-chloro-sulfonylphenyl) ethyltrimethoxy silane (CSPTMS), respectively. Compared with organosulfonic acid-functionalized wormhole-like mesostructured silica (WMS-SO3H), NR/WMS-SO3H demonstrated increased hydrophobicity while maintaining mesoporosity and a large surface area. The catalytic performance of the synthesized solid acids was subsequently evaluated via batch esterification of palmitic acid with methanol to generate fatty acid methyl esters for biodiesel synthesis. Compared with WMS–SO3H, NR/WMS–SO3H demonstrated superior catalytic activity, which was attributed to the synergistic interaction between the strongly acidic functional groups …

U.S. Bison Industry: An Analysis Of Production, Health, And Market Dynamics, Morgan A. Young

Research Papers

The bison market has been becoming increasingly popular within recent years. However, this market is challenging for producers due to disease concerns, aggressive bison behaviors, nutritional and facility requirements and market risks for bison operations. Since most bison data began in 2020, forecasting bison meat prices remains difficult. This raises an important question: can bison meat cut prices be effectively hedged by using live cattle futures prices? This paper examines USDA bison meat cut price data and live cattle futures prices to determine potential correlations. A regression analysis, along with a dummy variable approach is utilized to evaluate the relationship. …

A Systematic Review Of Biomonitoring Microplastics In Environmental Matrices: Emphasis On Airborne Particles, Dry Deposits, And Comparative Analysis With Traditional Methods, Faezeh Jahedi, Neamatollah Jaafarzadeh Haghighi Fard, Andrew Turner

School of Geography, Earth and Environmental Sciences

The use of plastics continues to rise each year due to their versatility and essential role in industries like manufacturing, agriculture, and food packaging. However, plastics present a serious environmental challenge because they take over 500 years to decompose. During this time, they break down into tiny particles known as microplastics (MPs), which are now found everywhere, water, soil, and even the air we breathe. Recently, researchers have even detected MPs in clouds, making their presence in the atmosphere a growing concern for both the environment and public health. Traditional methods for sampling MPs in the air, such as active …

Solving Standing Is Simply The Start: Climate Litigation Lessons Learned From The Evolution Of Rights Of Nature, Madeleine L. Kim

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

The global climate crisis continues to worsen. The Sixth Synthesis Report issued by the Intergovernmental Panel on Climate Change in 2023 unequivocally stated that “[w]idespread and rapid changes in the atmosphere, ocean, cryosphere and biosphere have occurred” and that “[h]uman-caused climate change is already affecting many weather and climate extremes in every region across the globe.” This report expressly states that climate change has “led to widespread adverse impacts and related losses and damages to nature and people” and that the “projected adverse impacts and related losses and damages from climate change escalate with every increment of global warming." However, …

Hippocampal Insulin Exists! In Vivo Sampling Methods, Basal Concentrations, Recurrent Hypoglycemia, And Behavioral Extracellular Insulin Responses, Starlette R. Douglass

Electronic Theses & Dissertations (2024 - present)

Insulin has widespread actions within the brain, including energy homeostasis, modulation of feeding, and as a key component of memory processes. Further, brain insulin dysfunction correlates with Alzheimer's disease and other neurodegenerative disorders. To this point, measurement of hippocampal insulin has been limited. Determining in vivo hippocampal insulin levels both at a healthy baseline and after, e.g., induction of a disease state or in response to cognitive challenge, is essential to advance our understanding of both insulin's procognitive actions and to guide potential therapeutic interventions.

We first sought to establish a sampling technique for insulin within awake and moving rats …

Impact Of The New York State Gender Recognition Act On Mental Health Outcomes Among Non-Binary Adults Served By The New York Public Mental Health System, Sahil Chaudhry

Electronic Theses & Dissertations (2024 - present)

This dissertation explores the impact of the 2021 New York State Gender Recognition Act (GRA) on mental health outcomes and service utilization among non-binary adults in the public mental health system. The GRA introduced pivotal legal reforms—including the option for an “X” gender marker and self-attestation for gender identity changes on state-issued documents—designed to affirm gender diversity and reduce structural barriers for transgender and non-binary populations. Guided by gender affirmation theory and minority stress frameworks, this study investigates how these legal shifts relate to changes in mental health service engagement and psychological well-being among non-binary individuals.

Using a difference-in-differences (DD) …

Heterogeneous Being: The Inhumanities And The Creative-Scientific Aesthetic, Steven L. Ogden

Electronic Theses & Dissertations (2024 - present)

Heterogeneous Being attempts to set the often-disunited aspects of the sciences and humanities in congruence and to extol and advance a hybrid creative-scientific aesthetic that moves beyond any restricted dimensions of its previously segregated fields of study. It likewise expresses the need to perpetuate that hybrid form of inquiry and representation to successfully address or convey the precarious realities of Earth’s ecological and environmental conditions. Heterogeneous Being asks readers to observe the inexhaustible proofs of our pluralized configurations with the nonhuman world, to recognize the agentic potentialities nonhuman subjects may hold both in and outside of those inhuman enmeshments, and …

Reproductive Justice: People Matter! History Matters! Places Matter!, Jazmin L. High

Electronic Theses & Dissertations (2024 - present)

Research has established that racial disparities in contraceptive use exist in the United States with African American women being more likely than white women to report using a contraceptive method associated with lower efficacy or no contraception at all. Several factors have been suggested to explain low uptake of highly effective forms of contraception and disparities including cost, systemic racism, negative attitudes, and cultural mistrust stemming from the history of medical racism. However, the lived experiences of rural African American Southern women are underrepresented in contraceptive research. Utilizing mixed methods, this study explores the contraceptive experiences of 14 rural African …

The Multifaceted Role Of Glutamate At Excitatory And Inhibitory Synapses, Maurice A. Petroccione

Electronic Theses & Dissertations (2024 - present)

Our thoughts, memories, and actions are finely controlled by the coordinated activity of neural circuits in the brain. Prior work has identified a multitude of molecular mechanisms that contribute to the generation of these higher order functions, yet we know very little about how our ability to learn and perform habitual actions change depending on how far neurotransmitters released from neurons can travel away from their point of release. This is the main focus of my work, which I carried out using a diverse toolbox and focusing on two brain regions: the hippocampus and the striatum. The hippocampus controls learning …

Contactin2(Cntn2)Creert2 Mouse Line, A New Genetic Tool For Temporal Control To Trace The Developing Neurons In The Nose, Alexis M. Semon

Electronic Theses & Dissertations (2024 - present)

Neuronal migration is a vital process in embryonic development. In rodents, the very first neurons that originate from the olfactory placode migrate toward the developing brain as part of the migratory mass. This migratory mass includes Gonadotropin-releasing hormone-1 (GnRH-1) neurons, pioneer/terminal nerve (TN) neurons, and olfactory ensheathing cells—a type of glial cell.

Contactin-2 (Cntn2), also referred to as transiently expressed axonal surface glycoprotein-1 (TAG-1), belongs to the contactin family of proteins, which is part of the immunoglobulin superfamily of cell adhesion molecules. Cntn2 has been extensively utilized as a transient/stage-specific molecular marker for various neuronal populations, including commissural neurons of …

Investigating Rna Dysfunction Of Inherited Neuromuscular And Neurodevelopmental Disease, Jacob H. Schroader

Electronic Theses & Dissertations (2024 - present)

ITPase deficiency is a rare but fatal, autosomal recessive enzyme deficiency involving encephalopathy, microcephaly, congenital cataracts, hypotonia, developmental delay, and dilated cardiomyopathy. Within a decade since the original description of the severe form in humans, there are huge gaps in the field regarding the underlying molecular mechanisms driving pathogenesis resulting from ITPase deficiency. Past studies have focused on characterization of the organism level ITPase-deficient phenotype, but the molecular and cellular characterization remains to be fully described. Due to the biochemical function and established biological role of the ITPase enzyme, investigation into the consequences of inosine accumulation and misincorporation into RNA …

Author-Centered Approaches In Ela Instruction: A Multiple Case Study Of Secondary English Teachers, Jennifer M. Lockhart Mchugh

Electronic Theses & Dissertations (2024 - present)

Literary authors are often neglected in secondary ELA (English Language Arts) literary instruction. Teachers are unsure how to teach about the author and how much time to spend on establishing the context for the text when the goal is to “cover” a variety of literary texts as part of a planned curriculum during the school year. Acknowledging the role of authors’ intentions as well as their experiences and aesthetic decisions in the production of literature may provide new entry points into literary texts for students. This multiple-case study of secondary English teachers and their high school students in a “bounded …

Does Type Of Metta Phrase Impact The Acceptability And Utility Of Loving-Kindness Interventions: An Experimental Evaluation, Shannon B. Underwood

Electronic Theses & Dissertations (2024 - present)

Loving-kindness (metta) meditation (LKM) is a widely utilized self-compassion intervention with numerous biopsychosocial benefits. Yet a smaller, emerging body of evidence suggests that LKM is difficult and various barriers impact its accessibility and effectiveness. Relational Frame Theory provides a behavioral and contextual perspective of language and cognition that may help clarify how LKM may yield receptivity or rejection of the practice itself. Prior research examining the role of language in LKM identified specific metta phrases more likely to evoke a coordinated (i.e., sameness/agreement) or oppositional (i.e., rejection/lacking) response, and found that indices of psychological suffering predicted oppositional responding (Underwood, 2023). …

Can Financial Inclusion-Based Interventions For Poverty Alleviation Build Sustainable Livelihoods? Voices From Mutual Solidarity Groups (Muso) In Haiti., Meera R. Bhat

Electronic Theses & Dissertations (2024 - present)

Scholars, policymakers, changemakers, and social workers have attempted to define, understand, and eradicate poverty. Its endurance raises the prospect that these efforts may be incomplete or faulty. This thesis will probe this concern by examining poverty and poverty alleviation programs through the lens of a holistic intervention-based framework known as the Sustainable Livelihoods Framework (SLF). The first paper introduces the SLF and uses it to undertake a conceptual analysis comparing demand and supply driven poverty alleviation interventions that are based on financial inclusion. Next it uses the SLF as a methodological tool to compare financial inclusion programs, as operationalized by …

Generative Identity Theft: Criminalizing Deepfakes Using The Right Of Publicity, Dustin Marlan

Faculty Publications

The right of publicity grants individuals control over the commercial use of their identity, particularly name, image, and likeness. Currently, publicity laws are a fragmented patchwork of state statutes and case law, leading to frequent calls for reform, including the establishment of a federal right of publicity. This issue has gained renewed urgency amid the rise of generative artificial intelligence and deepfake technologies. In response, Congress has introduced multiple bipartisan proposals—most prominently, the Senate’s No FAKES Act and the House’s No AI FRAUD Act—that seek to create federal protections against unauthorized digital replicas of likeness, voice, and other aspects of …

Volume 48 Masthead, Seattle University Law Review

Seattle University Law Review

Volume 48 Masthead

Voting Matters: Materiality Considerations And The Shareholder Vote, Renee M. Jones

Seattle University Law Review

For the shareholder franchise to have meaning, shareholders must have access to relevant information to inform their voting decisions. The securities laws’ disclosure requirements play an essential role in informing the shareholder vote.

This Essay focuses on the question of the materiality of information in the context of shareholder voting. It addresses the question of whether ESG-related information is material, positioning the materiality inquiry within the context of shareholders’ voting decisions. It explores the definition of materiality with a focus on the “reasonable investor” concept embedded within the definition. The Essay argues that the implicit expectations of many commentators that …

Volume 48 Masthead, Seattle University Law Review

Seattle University Law Review

Volume 48 Masthead

Understanding The Big Three’S Wavering Support Of Environmental And Social Shareholder Proposals, Jeff Schwartz, Jefferson Jensen

Seattle University Law Review

Because of their substantial equity portfolios, BlackRock, Vanguard, and State Street (the Big 3) are central players in corporate governance. It is, therefore, critical to understand how they vote. One puzzle is that their support for shareholder proposals on environmental and social matters appears to waiver. In 2020, for instance, BlackRock supported 11.1% of environmental proposals at S&P 500 firms. In 2021, it seemingly reversed course, supporting 55.2%. It then flipped again, supporting 32.1% in 2022. Such statistics suggest that the Big 3 are constantly changing their views on these topics. This Article seeks to better understand whether this is …