Digital Commons Network^™

On Snow's Intellectual Property And Immorality, David O. Taylor

Faculty Journal Articles and Book Chapters

In this Essay, I consider the “why” and “how” of Professor Snow’s controversial, countercultural, important, and relevant position that immorality may result in the denial of intellectual property protection. First, I highlight how surprising it is that Professor Snow’s argument springs from the theories underlying intellectual property protection, rather than the theories underlying the morality and ethics he believes ought to be considered in determining intellectual property protection. No one (that I know, at least) goes to the Environmental Protection Agency seeking better regulations to protect the environment and uses the labor desert theory of property rights as an argument. …

Who Regulates Abortion Now?, Nathan G. Cortez, Joanna L. Grossman

Faculty Journal Articles and Book Chapters

Contrary to both conventional wisdom and recent Supreme Court pronouncements, abortion is not simply a matter of state oversight. For a quarter century now, the federal government has been intimately involved in “regulating” abortion through the U.S. Food and Drug Administration’s approval and continued oversight over mifepristone and other abortion medications. This Article considers the extent to which federal abortion law both coexists and conflicts with state law, as it does with most areas of medicine. We evaluate which body of law is better able at achieving the goals of modern medicine that is evidence-based, ethical, consistent, and individualized.

Gravitational Property Theory, Monika U. Ehrman

Faculty Journal Articles and Book Chapters

Isaac Newton and Albert Einstein defined and redefined the field of physics. Their theoretical work on gravity is still considered a monumental discovery of their respective times. Although born centuries apart, the theory of gravity each advanced is still essential. Newton’s theory is applied on Earth and even throughout much of the solar system, while Einstein’s theory is used in special environments, such as near black holes. Neither theory is discarded, but instead used where appropriate. Likewise, gravitational property theory proposes that simple property theory—the ad coelum doctrine—is still appropriate for simple property, like stationary or vertical objects. And complex …

Copyright's Dominion, Shani Shisha

Faculty Journal Articles and Book Chapters

Copyright law is under attack. Scholars and activists have long argued that American copyright law is a shambolic mess—vague, unpredictable, and startlingly overbroad. But amidst the swirling chaos, one core principle has remained intact: the idea that copyright attaches only to intangible goods. In theory, copyright resides in an intangible work of authorship, not a physical artifact. It is the intellectual creation, rather than the material copy, that gives rise to copyright protection. Copyright law thus rests on a stark distinction between the intellectual property of authors and the personal property of consumers—in short, between the intangible work and the …

Targeting Bone In Cancer Therapy: Advances And Challenges Of Bisphosphonate-Based Drug Delivery Systems, Fariba Ganji, Mohammadmahdi Eshaghi, Hossein Shaki, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Background and Purpose: Bisphosphonates (BPs) are well-known for their strong affinity toward bone mineral matrices and are widely used to inhibit excessive osteoclast activity associated with various bone disorders. Beyond their clinical use, their unique bone-targeting capability has positioned them as promising ligands for drug delivery systems aimed at treating bone-related cancers. Approach: The review analyses published studies on BP-functionalized drug delivery systems, including direct drug conjugates, calcium-based nanomaterials, carbon-based nanostructures, and self-assembling systems such as micelles and liposomes. In vitro assays (e.g. hydroxyapatite binding, cell viability) and in vivo biodistribution studies are discussed to evaluate targeting efficiency and …

Development Of 2d Microfluidics Surface With Low-Frequency Electric Fields For Cell Separation Applications, Madushan Wickramasinghe, Dharmakeerthi Nawarathna

Electrical & Computer Engineering Faculty Publications

Cell separation techniques are widely used in many biomedical and clinical applications for the development of screening, diagnosis and therapeutic tests. Current 3D microfluidics-based cell separation methods have limited applications in part due to low throughput and technical complexity. To address these critical needs, we have developed a 2D microfluidics surface which is the miniaturized version of a 3D microfluids cell separation device. Using low-frequency electric fields (1–10 Vpp and 1 kHz–20 MHz), we have first studied dielectrophoresis, AC electro-osmosis and capillary flow within a sessile drop, and finally utilized the results to develop the 2D cell separation surface. Our …

Novel Micro-And Nanoformulations Of Paclitaxel For Targeting Metastatic Breast, Non-Small Cell Lung, And Pancreatic Cancers, Lobat Tayebi, Mehran Alavi

Electrical & Computer Engineering Faculty Publications

Nonlinear pharmacokinetics resulting from high lipophilic and low oral bioavailability, and hypersensitivity reactions and hyperlipidemia caused by formulation by Cremophor EL have limited clinical effectiveness of paclitaxel (Taxol). In this way, there is the critical necessity of innovative drug delivery systems (DDSs) to mitigate severe side effects and overcome clinical limitations of paclitaxel. In recent years, various micro- and nanoformulations, specifically polymeric nanoparticles (NPs) and lipid NPs, have been presented and approved by the Food and Drug Administration (FDA). In addition, other nanoformulations, such as polymeric nanoparticles (NPs), micelles, liposomes, and mesoporous silica nanoparticles, have shown promising results in vitro …

Cellax Nanoparticles: Taxane Nanoformulations For Solid Tumor Targeting, Lobat Tayebi, Mehran Alavi

Electrical & Computer Engineering Faculty Publications

Nanoparticles (NPs), specifically polymer-modified NPs, have illustrated unique therapeutic advantages compared to bulk materials. Cellax NPs have provided a promising approach to cancer therapy by improving drug delivery, targeting the tumor microenvironment, and potentially overcoming drug resistance, all while reducing overall toxicity compared to traditional taxane treatment. By the flash nanoprecipitation (FNP) method, docetaxel and cabazitaxel have been formulated with polyethylene glycol (PEG) modified-acetylated carboxymethylcellulose (CMC) polymer to increase biocompatibility, bioavailability, specific targeting, and modulate the tumor microenvironment. However, there are some challenges and clinical limitations related to this formulation, encompassing optimum targeted delivery to tumors, overcoming biological barriers, such …

Ai-Based Steganography Method To Enhance The Information Security Of Hidden Messages In Digital Images, Nhi Do Ngoc Huynh, Jiajun Jiang, Chung-Hao Chen, Wen-Chao Yang

Electrical & Computer Engineering Faculty Publications

With the increasing sophistication of Artificial Intelligence (AI), traditional digital steganography methods face a growing risk of being detected and compromised. Adversarial attacks, in particular, pose a significant threat to the security and robustness of hidden information. To address these challenges, this paper proposes a novel AI-based steganography framework designed to enhance the security of concealed messages within digital images. Our approach introduces a multi-stage embedding process that utilizes a sequence of encoder models, including a base encoder, a residual encoder, and a dense encoder, to create a more complex and secure hiding environment. To further improve robustness, we integrate …

Creativity, Fame And Power: A Critical Political Economy Of Social Media Comedy Skit In Nigeria, Idowu Badmus

Theses and Dissertations (Comprehensive)

This study explores social media comedy skits in Nigeria as a novel type of creativity that is both an economic and cultural activity with political and social implications within the context of the rapidly expanding global ecosystem of online content creation. Academic interest in social media comedy skits has grown as a result of their emergence as a popular culture within Nigeria's entertainment landscape. However, most research has focused on understanding this form of humour through its positive societal correlates. Hence, within the notion of industrialization of culture, which suggests that various methods of financing and arranging communication resources have …

Influence Of Temperature On Tfm Tolerance In Lake Sturgeon, Emily Bouffard

Theses and Dissertations (Comprehensive)

The lampricide, 3-trifluoromethyl-4-nitrophenol (TFM), has been used to successfully control invasive sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes for over 50 years. TFM’s effectiveness is due to the relatively low capacity of sea lamprey to detoxify TFM. Water temperature has been shown to increase TFM tolerance in larval sea lamprey. However, the effects of temperature on TFM sensitivity in non-target species such as the endangered lake sturgeon (Acipenser fulvescens) are poorly understood, particularly during their early life stages. To determine how temperature affected TFM sensitivity, age 1-year-plus (1+) lake sturgeon acclimated to 8, 16, …

Limiting H1n1 Replication Via The Dsrnai Pathway Using Sequence-Specific Ldsrna, Shawn Marie Sharon Carr, Stephanie Dewitte-Orr

Theses and Dissertations (Comprehensive)

The seasonal influenza virus causes a common respiratory illness that can be life threatening to the immunocompromised, the very young, and the elderly. The current strategies for avoiding a serious influenza virus infection are good hygiene practices and the annual influenza vaccine. Unfortunately, last year’s influenza virus vaccine effectiveness ranged between 32-60% for children and adolescents and 46-54% for adults. These low efficacy rates are due to the vaccine often targeting hemagglutinin, a highly variable surface protein. This thesis seeks to create a prophylactic treatment via the RNA interference (RNAi) response that targets the virus’s conserved genes that are integral …

Evaluating The Credibility Of Online Websites: A Digital Information Literacy Program, Emily C. Wood, Kim P. Roberts

Theses and Dissertations (Comprehensive)

The plethora of information currently available via the internet is greater than ever before. Given this, finding credible information is an exceedingly complex task for any information consumer, but especially so for children. Research shows that children have difficulty evaluating the credibility of online information and are more susceptible to believing misinformation compared to adolescents. While a growing body of research addresses children’s internet use, most research focuses on technology safety rather than the evaluation of online information. Several studies have found digital information literacy (DIL) interventions to be successful at increasing critical thinking and awareness of the criteria to …

Systemic Risk And The Social Contract, Kevin Frazier

SMU Science and Technology Law Review

The stability of the constitutional order turns, in part, on a stable economy and reliable advances in technology. Political order cannot withstand economic collapse or a massive technological failure. Such crises chip away at the collective will to adhere to the social contract because they indicate the government may not have the capacity to uphold its end of the bargain—protecting individual liberty from broad threats. “Unprecedented” economic downturns, however, have a precedent of emerging from the very deliberate decision of some actors to pursue extremely risky behavior in their self-interest at the expense of the public. Societal disruption from over-dependence …

Waterman V. Meta, Central District Of California

Historical and Topical Legal Documents

No abstract provided.

“It Is Tiny And It Is Everything”: Exploring The Effects Of Arts-Integrated Gardening On Experiences Of Ecological Grief Through Autoethnographic Research, Christina Kingsbury

Theses and Dissertations (Comprehensive)

This study explores how arts-integrated gardening affects experiences of ecological grief through autoethnography and draws on my personal experiences as a survivor of environmentally linked cancer and artist working with gardens through social practice. My research builds on two areas of emergent scholarship—investigations of ecological grief and gardens as sites for social work practice—to explore how social work may address ecological grief through arts-integrated gardening. I use a quilting autoethnography as a method of inquiry to foreground my subjective knowledge and analyze it through intersectional feminist, disability and decolonizing theories. By incorporating narrative analysis and arts-based inquiry—writing in place, poetic …

Quantifying Ecological Processes Predicting Barren-Ground Caribou (Ɂetthën; Rangifer Tarandus Groenlandicus) Occurrence Across A Heterogenous Northern Indigenous Protected And Conserved Area., Eric Jolin

Theses and Dissertations (Comprehensive)

Northern ecosystems are experiencing a period of rapid and unprecedented change, with implications for species distributions, mammal community dynamics, and habitat associations. Understanding the ecological processes that shape species distributions is crucial for developing effective conservation strategies that can adapt to such change. This study examines drivers of barren-ground caribou occurrence, a species of cultural and ecological significance, across Thaıdene Nëné Indigenous Protected Area, an ecologically intact landscape of high habitat heterogeneity straddling the treeline of the Northwest Territories. I use spatial and temporal variation in caribou detections generated by camera traps to test the relative importance of apparent competition, …

Npr1 As A Temperature-Sensitive Regulator Of Pipecolic Acid-Mediated Plant Systemic Immunity, Spencer Tout

Theses and Dissertations (Comprehensive)

Healthy plant development requires balancing both abiotic (e.g. climate) and biotic (e.g. pathogen) challenges, which intercept important signaling pathways in plants. For example, climate change-associated elevated temperature can negatively modulate various aspects of plant immunity, including the production of central immune signals salicylic acid (SA) and N-hydroxypipecolic acid (NHP). Since SA and NHP signaling both require the master immune co-activator protein NON-EXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), it is important to investigate NPR1 as a potentially temperature-regulated molecular hub. Although the NPR1 gene is not transcriptionally downregulated at elevated temperatures (28° C vs. 23° C), little is known about …

From Cuffs To Compassion: The Impact Of Relational Policing De-Escalation Approaches On Public Perceptions Of Safety, Satisfaction, Procedural Justice, And Police Legitimacy., Brook Snider

Theses and Dissertations (Comprehensive)

Academics, policy makers, and the public have called for the prioritization of de- escalation training and use in public-police interactions to reduce police use of force (PUoF) (e.g., Dubé, 2016; Iacobucci, 2014; Todak, 2017; Wortley et al., 2021). In response to various calls to action, the Ministry of the Solicitor General launched the Ontario Public-Police Interactions Training Aid Framework in 2023, which emphasizes the importance of utilizing a relational policing approach in public-police interactions (see Lavoie et al., 2022). However, despite changes in police training frameworks, relatively little is known about PUoF in Canada (Wortley et al., 2021), with similarly …

Impact Of Membrane Lipid Composition On The Structure And Function Of Uncoupling Proteins 1 And 2 From Arabidopsis Thaliana (Atucp1 And Atucp2), Elizabeth Silva

Theses and Dissertations (Comprehensive)

A proton gradient across the inner mitochondrial membrane (IMM) is required for the synthesis of adenosine triphosphate (ATP) via ATP synthase. In other words, generation of the proton gradient is coupled to the synthesis of ATP. Interestingly, uncoupling proteins (UCPs), also located in the IMM, dissipate the proton gradient, meaning that the gradient is not efficiently used for the production of ATP.¹ The mechanism of proton transport activity of UCPs has been hypothesized and widely debated for the past 20 years to also reduce oxidative stress by reducing the production of reactive oxygen species (ROS).² The majority of …

Timing Of Migration And Seasonal Movements Of Arctic Grayling (Thymallus Arcticus) In Relation To Water Temperature In The Kakisa River And Upper Mackenzie River, Nwt: Results From An Acoustic Telemetry Study., Levi Snook

Theses and Dissertations (Comprehensive)

Arctic grayling (Thymallus arcticus) are a cold-water salmonid that inhabit waterbodies throughout the circumpolar regions of the northern hemisphere. In the last decade, Ka'a'gee Tu First Nation members as well as local sport fishers, have observed lower catches of Arctic grayling during their annual spawning run in the Kakisa River, NWT. Many potential causes of this decline have been hypothesized including climate change and over harvesting. Outside of the general annual spawning activity in the headwaters of the Kakisa River, the ecology of the population, including post-spawn habitat use and migratory patterns, remained understudied. To address these knowledge gaps, acoustic …

“I’M Glad You're Alive.” Survivors’ Stories Of Leaving Intimate Partner Violence While Brain Injured, And The Embodied Experience Of Rebuilding Life And Relationships Post Violence., Robyn T. Mahood

Theses and Dissertations (Comprehensive)

Relationships are a fundamental part of the human experience, providing a buffer against stress and helping individuals live longer, happier, and healthier lives. However, survivors of intimate partner violence (IPV) who have experienced a brain injury (BI) encounter barriers to leaving violent relationships and engaging in new, non-violent connections. This qualitative research study drew from Indigenous and non-Indigenous methodologies to establish a blueprint for using storytelling in the IPV-BI population. Intersectionality theory, combined with critical disability theory, was employed as a transformative research paradigm to better analyze and explain the stories. Survivors encountered fear, trust concerns, continued violence from former …

Marine And Freshwater Habitats Used By Sympatric Anadromous Arctic Char (Salvelinus Alpinus) And Dolly Varden (S. Malma Malma) In The Central Canadian Arctic, Simon W. Depasquale Mr.

Theses and Dissertations (Comprehensive)

Two closely related but distinct species of char, Arctic Char (Salvelinus alpinus) and Dolly Varden (S. malma), are critically important to the food security and culture of Indigenous peoples in northern North America. Subsistence Inuit fishers in Kugluktuk, NU, Canada, have noticed changes in the timing and locations of their catches of char in the past ~ 10 years. In response, an ongoing partnered research program between the Kugluktuk Hunters and Trappers Organization (HTO) and scientists was formed to study Arctic Char and northern form Dolly Varden (S. malma malma). Char research near Kugluktuk presents a unique opportunity to further …

More Than Meets The Eye: A Phenomenological Study Of Self-Concept, Identity, And Meaning-Making In Adults With Acquired Vision Loss, Melinda M. Szilva

Theses and Dissertations (Comprehensive)

The qualitative research project examines the lived experience of acquired vision loss in adulthood and its impact on the way participants see themselves and the world around them, both sensorially and metaphorically. The research question, “What are the lived experiences of adults with acquired vision loss as they relate to identity and conceptions of self?” is informed by the researcher’s clinical practice as a psychotherapist in a low vision clinic. The dissertation includes a literature review focussed on the psychosocial aspects of vision loss to provide insight into the intended population and context for the study. Data for the phenomenological …

Comprehensive Analysis Of Environmental Particulate Matter: Chemical Composition And Microbial Assessment, Uyen T. L. Le

Theses and Dissertations (Comprehensive)

Rapid industrialization and population growth have contributed to a decline in air quality, with particulate matter (PM) posing particular concern. PM originates from both natural and human sources and often contains toxic chemicals and microorganisms, including potential pathogens. Inhalation of PM is linked to respiratory and cardiovascular diseases, underscoring the need to characterize better its chemical and biological composition in understudied region - Waterloo, Ontario, Canada. The present thesis is a culmination of three main parts. Part 1 will describe the use of the dithiothreitol (DTT) assay to quantify the oxidative potential of PM through DTT consumption of redox-active field …

Terpenes Mitigate Thc-Induced Working Memory Deficits: Behavioural Evidence Of The Entourage Effect Using A 2-Component Operant Memory Task, Lara Mitchell

Theses and Dissertations (Comprehensive)

Most research on cannabis and cognitive function has focused on delta-9-tetrahydrocannabinol (THC). However, this approach overlooks the complex chemical composition of cannabis products consumed by the public, which often includes cannabidiol (CBD) and various terpenes. These additional constituents may interact with THC to modulate its effects, a phenomenon known as the entourage effect. While this theory has gained traction, experimental evidence for the cognitive impact of terpenes in combination with THC remains limited. This study aimed to assess whether terpenes can mitigate THC-induced cognitive deficits using a 2-Component Operant Memory task. Male Sprague-Dawley rats received intraperitoneal injections of either …

Integrating Indigenous Values And Community Strengths To Achieve Indigenous Food Sovereignty And Community Well-Being In The Ka’A’Gee Tu First Nation, Northwest Territories, Jennifer K. Temmer

Theses and Dissertations (Comprehensive)

Northern Indigenous communities face disproportionate impacts from interconnected challenges related to climate change, food security, health, and cultural preservation, that threaten traditional food systems and practices. While there is a growing recognition of the importance of community-driven solutions, existing frameworks fail to integrate Indigenous values and local priorities effectively. This research addresses this gap by exploring how the Ka’a’gee Tu First Nation (KTFN) is responding to these crises through climate change adaptation efforts focused on food system sustainability as a pathway to self-sufficiency and community well-being. To contribute to these efforts, this dissertation uses Participatory Action Research to facilitate community-driven …

Visual Legal Rhetoric In The Age Of Generative Ai And Deepfakes: Renaissance Or Dark Ages?, Michael D. Murray

SMU Science and Technology Law Review

The paradoxical development of visual generative AI tools, such as OpenAI’s DALL-E 3, Midjourney, and Stable Diffusion, simultaneously signals a renaissance and a potential dark age in visual rhetoric and communication. On the one hand, these tools democratize the creation of visual content, empowering attorneys and others to become artists and illustrators of their legal communications without needing to learn how to draw. These AI systems can simplify complex legal concepts, bridge language barriers, and enhance advocacy. But on the other hand, the proliferation of deepfakes presents significant challenges for visual rhetoric. Deepfakes can quickly and easily create realistic but …

The Radical Potential Of Consumer Financial Protection, Vijay Raghavan

Faculty Scholarship

This Article offers a novel retheorization of consumer financial protection that surfaces its radical potential. That retheorization is motivated by two developments. The first is the rise of debtor movements over the last decade demanding the abolition or cancellation of debt, such as the recent national campaigns against student debt and medical debt. The second is an emerging view this Article identifies in sociological and legal scholarship. Recent scholarship understands consumer financial protection as in tension with the radical ambitions of debtor movements and neoliberal in its orientation: it operates to sustain market logics as opposed to contest them.

This …

Long-Term Increases In Wing Length Occur Independently Of Changes In Climate And Climate-Driven Shifts In Body Size, Tiffany Dias, Nathan P. Lemoine, Scott W. Yanco, Marketa Zimova, Rachael A. Bay, Brian C. Weeks

Biological Sciences Faculty Research and Publications

Recent widespread reductions in body size across species have been linked to increasing temperatures; simultaneous increases in wing length relative to body size have been broadly observed but remain unexplained. Size and shape may change independently of one another, or these morphological shifts may be linked, with body size mediating or directly driving the degree to which shape changes. Using hierarchical Bayesian models and a morphological time series of 27 366 specimens from five North American migratory passerine bird species, we tested the roles that climate and body size have played in shifting wing length allometry over four decades. We …