Digital Commons Network^™

Distinguishing Classes Of Neuroactive Drugs Based On Computational Physicochemical Properties And Experimental Phenotypic Profiling In Planarians, Danielle Ireland, Christina Rabeler, Sagar Rao , '22, R. J. Richardson, Eva-Maria S. Collins

Biology Faculty Works

Mental illnesses put a tremendous burden on afflicted individuals and society. Identification of novel drugs to treat such conditions is intrinsically challenging due to the complexity of neuropsychiatric diseases and the need for a systems-level understanding that goes beyond single molecule-target interactions. Thus far, drug discovery approaches focused on target-based in silico or in vitro high-throughput screening (HTS) have had limited success because they cannot capture pathway interactions or predict how a compound will affect the whole organism. Organismal behavioral testing is needed to fill the gap, but mammalian studies are too time-consuming and cost-prohibitive for the early stages of …

Student’S Disaster Preparedness Of Merapi Volcano, Indonesia Using Learning Simulation Virtual Reality (Lsvr) Model, Andi Irwan Benardi, Sumarmi Sumarmi, Syamsul Bachri, Erni Suharini, Atta Ur Rahman, Sriyono Sriyono, Saiful Amin, Joshua Vincent Gerar Yametis

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

This study evaluates the effectiveness of the Learning Simulation Virtual Reality (LSVR) model in enhancing disaster preparedness for Merapi Volcano and examines the relationship between disaster preparedness and student learning outcomes. Conducted with 120 students from two senior high schools located in disaster-prone areas near Merapi Volcano in Sleman Regency, Yogyakarta Province, Indonesia, the research employed a quasi-experimental design with a pretest-posttest control group setup. Essay-based assessments measured learning outcomes, while surveys gauged disaster preparedness levels. The analysis utilized an independent sample t-test and descriptive statistics, revealing the LSVR model’s strengths in delivering innovative and effective content, appealing design, and …

Groundwater Conservation Zone Model To Support Sustainable Tourism In Coastal Areas: A Case Study In Parangtritis Village, Yogyakarta, Indonesia, Sadewa Purba Sejati, Rivi Neritarani, Mohd Hairy Ibrahim

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

This study aims to determine the environmental characteristics in coastal areas and determine the groundwater conservation zone model in coastal regions. The research was conducted in Parangtritis Village, Bantul Regency, Yogyakarta. The data includes aquifer types, aeration zone materials, and groundwater depth. The data was processed and analysed using Arc GIS Pro software version 2.5. The data were processed by plotting and spatial interpolation techniques to produce thematic maps of environmental characteristics, namely aquifer-type maps, aeration zone material maps, groundwater depth maps, and land use maps. The thematic maps that have been generated are then classified and scored. The classification …

Microbiome Metabolic Capacity Is Buffered Against Phylotype Losses By Functional Redundancy, Kayla Cross, Noelle Beckman, Benjamin Jahnes, Zakee L. Sabree

Biology Faculty Publications

Many animals contain a species-rich and diverse gut microbiota that likely contributes to several host-supportive services that include diet processing and nutrient provisioning. Loss of microbiome taxa and their associated metabolic functions as result of perturbations may result in loss of microbiome-level services and reduction of metabolic capacity. If metabolic functions are shared by multiple taxa (i.e., functional redundancy), including deeply divergent lineages, then the impact of taxon/function losses may be dampened. We examined to what degree alterations in phylotype diversity impact microbiome-level metabolic capacity. Feeding two nutritionally imbalanced diets to omnivorous Periplaneta americana over 8 weeks reduced the diversity …

Spartan Daily, January 30, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 4

Enhancing Immunotherapy Efficacy With Synergistic Low-Dose Radiation In Metastatic Melanoma: Current Insights And Prospects, Zahid Rafiq, Mingyo Kang, Hampartsoum B Barsoumian, Gohar S Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W Welsh

Faculty, Staff and Student Publications

Recent advances in oncology research have highlighted the promising synergy between low-dose radiation therapy (LDRT) and immunotherapies, with growing evidence highlighting the unique benefits of the combination. LDRT has emerged as a potent tool for stimulating the immune system, triggering systemic antitumor effects by remodeling the tumor microenvironment. Notably, LDRT demonstrates remarkable efficacy even in challenging metastatic sites such as the liver (uveal) and brain (cutaneous), particularly in advanced melanoma stages. The increasing interest in utilizing LDRT for secondary metastatic sites of uveal, mucosal, or cutaneous melanomas underscores its potential efficacy in combination with various immunotherapies. This comprehensive review traverses …

Evaluation Of Teachers’ Skills And Their Current Level Of Using Atomic Model Kits In Teaching Chemical Bonding And Atomic Structure In Gasabo District Of Rwanda, Francois Niyongabo Niyonzima, Nsabayezu Ezechiel, Aloys Iyamuremye, Jean Baptiste Nkurunziza, Angelique Nzavuga Izere, Claude Karegeya, Emmanuel Gakuba, Ruth Ntihabose, Jean Pierre Nahimana

Australian Journal of Teacher Education

This study investigates the current level of using the atomic model kits and their effectiveness in teaching atomic structure and chemical bonding. The study used a sample of 54 chemistry teachers randomly sampled from a list of all eligible teachers in Gasabo. An explanatory sequential research design was adopted to collect and analyze the data.  The quantitative data collected through the Likert scale questionnaire were analyzed by using Excel 2016 and the Social Package for Social Science (SPSS). The qualitative data were analyzed by using interpretive and thematic analysis. The study revealed a substantial difference based on teachers' working …

Hypoxia Signaling In The Adipose Tissue, Phu M Huynh, Fenfen Wang, Yu A An

Faculty, Staff and Student Publications

Obesity per se is rapidly emerging all over the planet and further accounts for many other life-threatening conditions, such as diabetes, cardiovascular diseases, and cancers. Decreased oxygen supply or increased relative oxygen consumption in the adipose tissue results in adipose tissue hypoxia, which is a hallmark of obesity. This review aims to provide an up-to-date overview of the hypoxia signaling in the adipose tissue. First, we summarize literature evidence to demonstrate that hypoxia is regularly observed during adipose tissue remodeling in humans and rodent models with obesity. Next, we discuss how hypoxia-inducible factors (HIFs) are regulated and how adipose tissues …

Efektivitas Kartu Permainan Dan Kombinasi Video Animasi -Kartu Permainan Dan Terhadap Kepatuhan Minum Tablet Tambah Darah, Ardi Bastian, Agustin Widyowati, Riza Yuliawati, Kristin Ernawati, Dian Mustikawati

Perilaku dan Promosi Kesehatan: Indonesian Journal of Health Promotion and Behavior

Background: Screening results at the Baron Health Center, Nganjuk Regency showed that the prevalence of anemia in adolescent girls reached 60.89%. Although counseling and provision of iron tablets to increase hemoglobin levels have been carried out, adolescent girls' adherence to iron tablet is still low.

Objective: The study aims to see the differences in two educational methods to improve adolescent girls' compliance in consuming iron tablet

Method: A total of 201 adolescent girls were divided into 2 different groups. The first group was given education in the form of game cards, while the second group was given combination education cards …

One Health Investigation Following A Cluster Of Crimean-Congo Haemorrhagic Fever, North Macedonia, July To November 2023, Dejan Jakimovski, Pavle Banović, Katerina Spasovska, Goran Rangelov, Marija Cvetanovska, Fadil Cana, Verica Simin, Ivana Bogdan, Dragana Mijatović, Aleksandar Cvetkovikj, Igor Djadjovski, Iva Christova, Eleftherios Meletis, Polychronis Kostoulas, Brigitta Zana, Zsófia Lanszki, Tamás Görföl, Zsófia Tauber, Gábor Kemenesi

School of Biomedical Sciences

Background: Crimean–Congo haemorrhagic fever(CCHF) is a severe illness characterised by fever,bleeding and high case-fatality rates. The disease iscaused by CCHF virus (CCHFV), transmitted by ticksand infectious body fluids and tissues. Aim: After CCHFwas diagnosed in three persons in 2023, we aimed toinvestigate the presence of antibodies against CCHFVin healthcare workers (HCW), sheep and goats, andof CCHFV in ticks, in an area in North Macedonia andcharacterise virus strains. Methods: In 2023, we collected blood samples from HCWs involved in treating CCHF patients and sera and ticks from sheep andgoats in the village in North Macedonia where theindex case resided. The blood …

Online Media Sentiment Analysis Of Shrimp And Salmon In The United States, Jingjing Tao, Kwamena K. Quagrainie

Department of Agricultural Economics Faculty Publications

There is a growing interest in the U.S. seafood and aquaculture market; however, studies utilizing online information to understand this market are limited. This study employs online media analytics to obtain insights into consumer perceptions and potential demand signals for shrimp and salmon in the U.S. Our results show that platform X is the preferred medium for shrimp and salmon discussions, with shrimp's physical quality and salmon's environmental impact being the two major perception drivers. Additionally, autoregressive modeling is conducted to explore the dynamics of net sentiments. Farmed shrimp and salmon consistently exhibit lower net sentiments compared to their wild …

Stroma-Derived Dickkopf-1 Contributes To The Suppression Of Nk Cell Cytotoxicity In Breast Cancer, Seunghyun Lee, Biancamaria Ricci, Jennifer Tran, Emily Eul, Jiayu Ye, Qihao Ren, David Clever, Julia Wang, Pamela Wong, Michael S Haas, Sheila A Stewart, Cynthia X Ma, Todd A Fehniger, Roberta Faccio

2020-Current year OA Pubs

Mechanisms related to tumor evasion from NK cell-mediated immune surveillance remain enigmatic. Dickkopf-1 (DKK1) is a Wnt/β-catenin inhibitor, whose levels correlate with breast cancer progression. We find DKK1 to be expressed by tumor cells and cancer-associated fibroblasts (CAFs) in patient samples and orthotopic breast tumors, and in bone. By using genetic approaches, we find that bone-derived DKK1 contributes to the systemic DKK1 elevation in tumor-bearing female mice, while CAFs contribute to DKK1 at primary tumor site. Systemic and bone-specific DKK1 targeting reduce tumor growth. Intriguingly, deletion of CAF-derived DKK1 also limits breast cancer progression, without affecting its levels in circulation, …

The Pulse, 2001, V11 N3, Summer, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 2000, V10 N4, Fall, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1992, V1 N1, Fall, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1992 Summer, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1991 Summer, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1991 Fall, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1990 Winter, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1989 Fall, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

The Pulse, 1983, N4, Spring, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of The Pulse, a publication for Dreyer Medical Clinic patients. This was a newsletter published for patients reporting on Dreyer news, events, classes, and staffing updates.

Heartbeat, 2003 July, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of Dreyer Heartbeat. This was an employee newsletter published by the marketing department, reporting on news, events, and staffing updates at Dreyer Medical Clinic.

Heartbeat, 1997 April, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of Dreyer Heartbeat. This was an employee newsletter published by the marketing department, reporting on news, events, and staffing updates at Dreyer Medical Clinic.

Heartbeat, 1996 November, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of Dreyer Heartbeat. This was an employee newsletter published by the marketing department, reporting on news, events, and staffing updates at Dreyer Medical Clinic.

Dreyer Heartbeat, 1994 October-November, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of Dreyer Heartbeat. This was an employee newsletter published by the marketing department, reporting on news, events, and staffing updates at Dreyer Medical Clinic.

Dreyer Heartbeat, 1992 October-November, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of Dreyer Heartbeat. This was an employee newsletter published by the marketing department, reporting on news, events, and staffing updates at Dreyer Medical Clinic.

Dreyer Heartbeat, 1992 February-March, Advocate Health - Midwest

Historical Documents - Combined

Dreyer Medical Clinic, Aurora, IL: An issue of Dreyer Heartbeat. This was an employee newsletter published by the marketing department, reporting on news, events, and staffing updates at Dreyer Medical Clinic.

Preparation Of The Compound (Y1−Xpbxba2cu2.85la0.15o6+Δ) Superconductor And Research Of The Impact Of Partial Substitution On The Structural Properties, Ekhlas Hassan, Haider M. J. Haider

Baghdad Science Journal

The purpose of this study is to find out the optimal substitution ratio for lead with yttrium through the structural properties of the prepared compounds. The superconductor compound (Y1−xPbxBa2Cu2.85La0.15O6+δ) was prepared by the solid state reaction (SSR) method. The effect of partial substitution for the lead on the compound's structural characteristics has been studied. The variation of (x) is (0, 0.05, 0.1, 0.15, 0.20, 0.25). With a pressure of 7 tons per square centimeter, the combined powder was formed into a disc with a thickness of (about 0.2 cm). The samples were sintered for a while (24 hours ) at …

Calculating The Radii Of The Even-Even Nickel Isotopes, Safa Mohsin Ibrahim, Abdallah Ben Rhaiem, Sameera Ahmed Ebrahiem

Baghdad Science Journal

The current investigation concentrated on even-even nuclei forms to isotopes that have masses number less than 100 (A>100) to . This includes a look at deformation parameters derived from reduced electric transition probability as well as distortions parameters derived by intrinsic electric quadrupole moment. A Roots mean square Radius We studied the most important deformation parameters (d,b₂) , and major and minor of ellipsoid axes (a,b) in addition to the difference between these axes (DR) All these parameters were calculated using the deformed shell model equations and applied theoretically in a special program. Differences in nuclei forms …

Study Of The Relationship For Neutron And Proton Skin Thickness On The Neutron Equation Of State For 18ne-18o Pair Mirror Nuclei, Sala Sami Hamza, Ban Sabah Hameed

Baghdad Science Journal

Within the framework of the shell model, the single-particle wave functions of Hartree-Fock approximation adopted with Skyrme interactions like Skxtb, Skxs25, Sly4 and Bsk9 to get the thickness of the neutron skin, the mirror radii and the charges mirror radii for 18Ne-18O pair mirror nucleus. The wave functions were calculated using the NuShellX@MSU shell model code. The computed values of root-mean-square-radii are influenced by the type of interaction employed. The symmetry energy and its slope at nuclear saturation density and the mirror energy displacement were also determined. Comparisons between theoretical and experimental data were made and it was concluded that …